kynurenine has been researched along with 4-chlorokynurenine in 12 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 4 (33.33) | 29.6817 |
| 2010's | 5 (41.67) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Baron, BM; Guidetti, P; McDonald, IA; Palfreyman, MG; Salituro, FG; Schmidt, W; Schwarcz, R; Tomlinson, RC; Wu, HQ | 1 |
| Hokari, M; Schwarcz, R; Smith, QR; Wu, HQ | 1 |
| Lee, SC; Schwarcz, R; Wu, HQ | 1 |
| Guidetti, P; Schwarcz, R; Wu, HQ | 1 |
| Lee, SC; Schwarcz, R | 1 |
| Lee, SC; Scharfman, HE; Schwarcz, R; Wu, HQ | 1 |
| Tan, L; Yu, JT | 1 |
| Can, A; Dell, MJ; Gould, TD; Piantadosi, SC; Pribut, HJ; Schwarcz, R; Snodgrass, HR; Wu, HQ; Zanos, P; Zarate, CA | 1 |
| Schwarcz, R; Snodgrass, HR; Yaksh, TL | 1 |
| Alferova, VA; Aparin, IO; Chistov, AA; Korshun, VA; Novikov, RA; Proskurin, GV; Rogozhin, EA; Shuvalov, MV; Solyev, PN; Suchkova, TA; Tyurin, AP; Ustinov, AV | 1 |
| Chekan, JR; Luhavaya, H; McKinnie, SMK; Moore, BS; Sigrist, R | 1 |
| Adeojo, LW; Evans, JW; Farmer, CA; George, JM; Gould, TD; Greenstein, D; Henter, ID; Kadriu, B; Machado-Vieira, R; Mannes, AJ; Oppenheimer, M; Park, LT; Smith, MA; Snodgrass, HR; Yuan, P; Zanos, P; Zarate, CA | 1 |
1 review(s) available for kynurenine and 4-chlorokynurenine
| Article | Year |
|---|---|
The kynurenine pathway in neurodegenerative diseases: mechanistic and therapeutic considerations.
Topics: Aging; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Enzyme Inhibitors; Humans; Huntington Disease; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenic Acid; Kynurenine; Microglia; Molecular Targeted Therapy; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Neurotoxins; Parkinson Disease; Quinolinic Acid; Receptors, G-Protein-Coupled; Receptors, N-Methyl-D-Aspartate; Tryptophan | 2012 |
1 trial(s) available for kynurenine and 4-chlorokynurenine
| Article | Year |
|---|---|
A Randomized Trial of the N-Methyl-d-Aspartate Receptor Glycine Site Antagonist Prodrug 4-Chlorokynurenine in Treatment-Resistant Depression.
Topics: Adolescent; Adult; Aged; Animals; Antidepressive Agents; Brain; Brain Chemistry; Cross-Over Studies; Depressive Disorder, Treatment-Resistant; Double-Blind Method; Female; Glycine; Humans; Kynurenine; Magnetic Resonance Imaging; Male; Mice; Middle Aged; Prodrugs; Psychiatric Status Rating Scales; Receptors, N-Methyl-D-Aspartate; Treatment Outcome; Young Adult | 2020 |
10 other study(ies) available for kynurenine and 4-chlorokynurenine
| Article | Year |
|---|---|
Enzyme-activated antagonists of the strychnine-insensitive glycine/NMDA receptor.
Topics: Animals; Binding Sites; Binding, Competitive; Cerebral Cortex; Chromatography, High Pressure Liquid; Cyclization; Glycine; Kinetics; Kynurenine; Lyases; Male; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Strychnine; Transaminases | 1994 |
Facilitated brain uptake of 4-chlorokynurenine and conversion to 7-chlorokynurenic acid.
Topics: Amino Acids; Animals; Biotransformation; Brain; Excitatory Amino Acid Antagonists; Kynurenic Acid; Kynurenine; Male; Perfusion; Prodrugs; Rats; Rats, Sprague-Dawley | 1996 |
Systemic administration of 4-chlorokynurenine prevents quinolinate neurotoxicity in the rat hippocampus.
Topics: Animals; Brain Diseases; Dialysis Solutions; Hippocampus; Injections, Intraperitoneal; Kynurenic Acid; Kynurenine; Male; Microdialysis; Neuroprotective Agents; Prodrugs; Quinolinic Acid; Rats; Rats, Sprague-Dawley | 2000 |
In situ produced 7-chlorokynurenate provides protection against quinolinate- and malonate-induced neurotoxicity in the rat striatum.
Topics: 3-Hydroxyanthranilic Acid; Animals; Biotransformation; Corpus Striatum; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Infusions, Parenteral; Kynurenic Acid; Kynurenine; Male; Malonates; Neurons; Neuroprotective Agents; Prodrugs; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, Glycine | 2000 |
Excitotoxic injury stimulates pro-drug-induced 7-chlorokynurenate formation in the rat striatum in vivo.
Topics: Animals; Corpus Striatum; Injections, Intraperitoneal; Kynurenic Acid; Kynurenine; Male; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Osmolar Concentration; Prodrugs; Quinolinic Acid; Rats; Rats, Sprague-Dawley | 2001 |
L-4-chlorokynurenine attenuates kainate-induced seizures and lesions in the rat.
Topics: Animals; Brain; Excitatory Amino Acid Antagonists; Kainic Acid; Kynurenine; Male; Prodrugs; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Seizures | 2002 |
The Prodrug 4-Chlorokynurenine Causes Ketamine-Like Antidepressant Effects, but Not Side Effects, by NMDA/GlycineB-Site Inhibition.
Topics: Animals; Behavior, Animal; Conditioning, Psychological; Depressive Disorder, Major; Glycine; Hindlimb Suspension; Ketamine; Kynurenine; Male; Mice; Microdialysis; Prodrugs; Receptors, N-Methyl-D-Aspartate; Swimming | 2015 |
Characterization of the Effects of L-4-Chlorokynurenine on Nociception in Rodents.
Topics: Amines; Analgesics; Animals; Brain; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Kynurenic Acid; Kynurenine; Male; Prodrugs; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 2017 |
4-Chloro-L-kynurenine as fluorescent amino acid in natural peptides.
Topics: Anti-Bacterial Agents; Biological Products; Fluorescence; Kynurenine | 2018 |
Biosynthesis of l-4-Chlorokynurenine, an Antidepressant Prodrug and a Non-Proteinogenic Amino Acid Found in Lipopeptide Antibiotics.
Topics: Amino Acids; Anti-Bacterial Agents; Antidepressive Agents; Arylformamidase; Crystallography, X-Ray; Kynurenine; Lipopeptides; Models, Molecular; Molecular Structure; Prodrugs; Tryptophan Oxygenase | 2019 |