kynurenine has been researched along with 3-hydroxyanthranilic acid in 119 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 31 (26.05) | 18.7374 |
| 1990's | 27 (22.69) | 18.2507 |
| 2000's | 20 (16.81) | 29.6817 |
| 2010's | 29 (24.37) | 24.3611 |
| 2020's | 12 (10.08) | 2.80 |
| Authors | Studies |
|---|---|
| Birnbaum, D; Böttcher, F; König, A; Lutzmann, H; Samsonova, IA | 1 |
| Kimmig, J; Kreysel, HW; Meyerhoff, K | 1 |
| Soda, K; Tanizawa, K | 1 |
| Muramatsu, S; Suzuki, M; Takahashi, T; Watanabe, M; Yoshida, M | 1 |
| Fokkens, W; Haije, WG; Hop, WC; Peters, HA; Portengen, H; Teulings, FA; van der Werf-Messing, B | 1 |
| Bell, ED | 1 |
| Arend, RA; Brown, RR; Huang, T; Kuntz, RE; Moore, JA | 1 |
| Clark, JA; Clark, MS; Palfreyman, ES; Palfreyman, MG | 1 |
| Ionascu, L; Ionescu, G; Romas, NA; Sholem, S; Veenema, RJ | 1 |
| Hankes, LV; Schmaeler, M | 1 |
| Brown, RR; Yeh, JK | 1 |
| Fokkens, W; Mulder-Kooy, GE; Peters, HA; Teulings, FA; Van Der Werf-Messing, B | 1 |
| Gaertner, FH; Shetty, AS | 1 |
| Balasubramanian, D; Luthra, M | 1 |
| Baran, H; Schwarcz, R | 1 |
| Gramsbergen, JB; Schwarcz, R; Speciale, C; Vezzani, A | 1 |
| Bissbort, SH; Ubbink, JB; Vermaak, WJ | 1 |
| Altschule, MD; Frank, HA; Hegedus, ZL; Nayak, U | 1 |
| Anderson, K; Kaufman, JE; Parsons, CL | 1 |
| Abdel-Hamied, HA; Abdel-Tawab, GA; Aboul-Azm, T; Ebied, SA; el-Kholy, ZA; el-Sharaky, AS; el-Toukhy, MA | 1 |
| Evangelista, SJ; Rogers, KS | 1 |
| Shirasawa, E; Tomoda, A; Yoneyama, Y | 1 |
| Kuntze, I; Schievelbein, H | 1 |
| Ehrhart, H | 1 |
| Bühner, R; Bührlen, E; Byrd, D; Kochen, W | 1 |
| Fujii, K; Watanabe, M | 1 |
| Karawya, E; Mostafa, MH; Osman, N | 1 |
| Court, S; McKiernan, J; Mellor, DH | 1 |
| Allegri, G; Cardin Dè Stefani, EL; Costa, C; De Antoni, A; Vanzan, S | 1 |
| Arend, RA; Brown, RR; Wolf, H | 1 |
| Lapin, IP; Umanskaia, LG | 1 |
| Court, S; Edson, J; Lacey, K; McKiernan, J; Mellor, D | 1 |
| Chen, CY; Heyes, MP; Markey, SP; Naritsin, DB; Saito, K | 1 |
| Heyes, MP; Markey, SP; Saito, K | 1 |
| Hiraku, Y; Inoue, S; Kawanishi, S; Nishino, K; Oikawa, S; Tada, S; Yamamoto, K | 1 |
| Christen, S; Garner, B; Stocker, R; Thomas, SR | 1 |
| Malina, HZ; Martin, XD | 1 |
| Heyes, MP; Major, EO; Markey, SP; Milstien, S; Saito, K; Vickers, JH | 1 |
| Stutchbury, GM; Truscott, RJ | 1 |
| Heyes, MP; Markey, SP; Nowak, TS; Saito, K | 1 |
| Chen, CY; Crowley, JS; Heyes, MP; Markey, SP; Masana, M; Saito, K | 1 |
| Heyes, MP | 1 |
| Fornstedt-Wallin, B; Fredriksson, G; Luthman, J; Vänerman, E | 1 |
| Heyes, MP; Markey, SP; Noma, A; Saito, K; Seishima, M; Suyama, K | 1 |
| Elderfield, AJ; Truscott, RJ | 1 |
| Watanabe, M | 1 |
| Acuña-Castroviejo, D; Molina-Carballo, A; Muñóz-Hoyos, A; Rodríguez-Cabezas, T; Ruiz-Cosano, C; Uberos-Fernández, J | 1 |
| Kabuto, H; Nishijima, Y; Ogawa, N; Uchida, A; Yamamoto, N; Yokoi, I | 1 |
| Brown, OR; Dang, Y; Xia, C | 1 |
| Chiarugi, A; Moroni, F | 1 |
| Hasegawa, H; Hasegawa, Y; Ikeda, R; Nagamura, Y; Naito, J; Negishi, S | 1 |
| Handley, SL; Kariyawasam, SH | 1 |
| Ishiguro, I; Nagamura, Y; Naito, J; Uesugi, K | 1 |
| Fujigaki, S; Fujii, H; Maekawa, N; Morita, T; Noma, A; Saito, K; Seishima, M; Takemura, M; Takeuchi, S; Wada, H | 2 |
| Hasegawa, Y; Ishiguro, I; Nagamura, Y; Naito, J; Negishi, S | 1 |
| Guidetti, P; Schwarcz, R; Wu, HQ | 1 |
| Ceresoli-Borroni, G; Goodman, JH; Guidetti, P; Scharfman, HE; Schwarcz, R; Speciale, C; Varasi, M; Wu, HQ | 1 |
| Atwood, CS; Bowden, EF; Bush, AI; Chylack, LT; Faget, KY; Goldstein, LE; Hartshorn, M; Huang, X; Leopold, MC; Lim, JT; Muffat, JA; Saunders, AJ; Scarpa, RC; Tanzi, RE | 1 |
| Bauer, TM; Dufter, C; Opelz, G; Röse, L; Simon, H; Terness, P; Watzlik, A | 1 |
| Bianchi, R; Fallarino, F; Fioretti, MC; Grohmann, U; Orabona, C; Puccetti, P; Spreca, A; Vacca, C | 1 |
| Baran, H; Draxler, M; Kepplinger, B; Nohl, H; Staniek, K; Stur, J | 1 |
| TOMPSETT, SL | 1 |
| BROWN, RR; HANKES, LV; LIPPINCOTT, S; SCHMAELER, M | 1 |
| GHOLSON, RK; HAYAISHI, O; ICHIYAMA, A; NISHIZUKA, Y | 1 |
| Murgia, S; Rescigno, A; Sanjust, E; Soddu, G | 1 |
| Alegre, E; González, A; López, AS | 1 |
| Arbatova, J; D'Amato, E; Reeben, M; Vaarmann, A; Zharkovsky, A | 1 |
| Chiarugi, A; Feder-Mengus, C; Frey, DM; Heberer, M; Misteli, H; Oertli, D; Reschner, A; Rosenthal, R; Schumacher, R; Spagnoli, GC; Weber, WP; Zajac, P | 1 |
| Alegre, E; Carosella, E; González, A; LeMaoult, J; López, AS | 1 |
| Bellac, CL; Christen, S; Coimbra, RS; Leib, SL | 1 |
| Dalcin, KB; Dutra-Filho, CS; Funchal, C; Latini, A; Leipnitz, G; Schumacher, C; Scussiato, K; Solano, A; Wajner, M; Wannmacher, CM; Wyse, AT | 1 |
| Darlington, LG; Forrest, CM; Mackay, GM; Oxford, L; Stone, TW; Stoy, N | 1 |
| da Costa Ferreira, G; de Souza Wyse, AT; Dutra-Filho, CS; Duval Wannmacher, CM; Latini, A; Schuck, PF; Tonin, A; Viegas, CM; Wajner, M | 1 |
| Bauer, TM; Baumeister, S; Bosch, N; Gebhard, MM; Germann, G; Jiga, L; Kleist, C; Opelz, G; Radu, CA; Terness, P | 1 |
| Cwik, M; Llenos, IC; Miller, CL; Walkup, J; Weis, S | 1 |
| Backhaus, C; Hardeland, R; Laatsch, H; Rahman, H; Scheffler, S | 1 |
| Smith, AJ; Smith, RA; Stone, TW | 1 |
| Babb, JS; Gabbay, V; Gonen, O; Katz, Y; Klein, RG; Liebes, L; Liu, S; Mendoza, S | 1 |
| Cervi, L; Díaz Lujan, C; Fretes, RE; Knubel, CP; Martínez, FF; Motrán, CC; Theumer, MG | 1 |
| Alonso, CM; Babb, JS; Gabbay, V; Guttman, LE; Hirsch, GS; Katz, Y; Klein, RG; Liebes, L; Mendoza, S | 1 |
| Murray, MF | 1 |
| Aweeka, F; Barbour, JD; Brenchley, JM; Deeks, SG; Douek, DC; Favre, D; Hecht, FM; Huang, Y; Hunt, PW; Jayawardene, A; Kanwar, B; Loke, P; Lowe, MM; Martin, JN; McCune, JM; Mold, J; Seu, L | 1 |
| Aerts, T; Brouns, R; De Deyn, PP; De Surgeloose, D; Scharpé, S; Verkerk, R; Wauters, A | 1 |
| Kowalewska, A; Mysliwiec, M; Pawlak, D; Pawlak, K | 1 |
| Antel, JP; Bauman, A; Choi, N; Cosenza-Nashat, M; Cui, QL; Durafourt, BA; Krause, D; Lee, SC; Suh, HS; Tarassishin, L; Zhao, ML | 1 |
| Du Preez, JL; Harvey, BH; Möller, M | 1 |
| Kolodziej, L | 2 |
| Eussen, SJ; Midttun, Ø; Nygård, O; Tell, GS; Theofylaktopoulou, D; Ueland, PM; Ulvik, A; Vollset, SE | 1 |
| Fukuwatari, T; Funakoshi, H; Kadota, E; Kanai, M; Nakamura, T; Sano, M; Shibata, K; Terakata, M | 1 |
| Ciorba, MA | 1 |
| Eussen, SJ; Midttun, Ø; Nygård, O; Theofylaktopoulou, D; Ueland, PM; Ulvik, A | 1 |
| Cao, X; Hou, W; Huang, G; Li, Y; Zhang, J; Zhang, Y | 1 |
| Barlera, S; Fracasso, C; Gobbi, M; Guiso, G; Kurola, J; Latini, R; Lucchetti, J; Masson, S; Montanelli, A; Pettilä, V; Ristagno, G; Skrifvars, MB; Tiainen, M; Vaahersalo, J; Varpula, T | 1 |
| Fukuwatari, T; Ohno, T; Sano, M; Shibata, K | 1 |
| Brody, LC; Brosnan, JT; Brosnan, ME; Deac, OM; Fan, R; Gibney, ER; Laird, E; Midttun, Ø; Mills, JL; Molloy, AM; Shane, B; Ueland, PM; Wang, Y | 1 |
| Oxenkrug, GF | 1 |
| Chi, YY; Coats, B; Gregory, JF; Midttun, Ø; Ralat, M; Rios-Avila, L; Stacpoole, PW; Ueland, PM | 1 |
| Badawy, AA; Bano, S | 1 |
| Balderas, PM; Cervantes, GI; González-Esquivel, D; Jiménez-Anguiano, A; Lugo-Huitrón, R; Pérez-de la Cruz, V; Pineda, B; Ramírez-Ortega, D; Reyes-Ocampo, J; Ríos, C; Sánchez-Chapul, L; Silva-Adaya, D | 1 |
| Dierkes, J; Drevon, CA; Gudbrandsen, OA; Karlsson, T; Midttun, Ø; Nygård, O; Pedersen, ER; Strand, E; Ueland, PM; Øyen, J | 1 |
| Brody, LC; Deac, OM; Fan, R; Gardiner, CM; Lu, Z; McCann, A; Meyer, K; Midttun, Ø; Mills, JL; Molloy, AM; Quinn, L; Shane, B; Ueland, PM | 1 |
| González-Esquivel, D; Pérez de la Cruz, V; Pineda, B; Ramírez-Ortega, D; Ramiro-Salazar, A; Ríos, C | 1 |
| Advani, R; Giil, LM; Midttun, Ø; Refsum, H; Smith, AD; Ueland, PM; Ulvik, A | 1 |
| Butler, LM; Gao, YT; Huang, JY; Jin, A; Koh, WP; Midttun, Ø; Ueland, PM; Ulvik, A; Wang, R; Yuan, JM | 1 |
| Belladonna, ML; Bianchi, R; Bicciato, S; Cecchetti, V; Fallarino, F; Gargaro, M; Grohmann, U; Iacono, A; Iamandii, IM; Manni, G; Massari, S; Matino, D; Mazza, EMC; Mondanelli, G; Orabona, C; Pallotta, MT; Panfili, E; Proietti, E; Puccetti, P; Scalisi, G; Tabarrini, O; Vacca, C; Volpi, C | 1 |
| Becquemont, L; Boniface, B; Boursier-Neyret, C; Chanson, P; Colle, R; Corruble, E; David, DJ; Falissard, B; Fève, B; Masson, P; Verstuyft, C; Walther, B; Werner, E | 1 |
| Allers, KA; Harkin, A; McLoughlin, DM; Ryan, KM | 1 |
| Gao, M; Lang, Z; Nie, Y; Wang, Z; Xu, X; Yang, Q; Zhang, G; Zhang, N | 1 |
| Cui, C; Lin, J; Sun-Waterhouse, D | 1 |
| Bakker, L; Dagnelie, PC; Eussen, SJPM; Köhler, S; Midttun, Ø; Ramakers, IHGB; Schram, MT; Stehouwer, CDA; Ueland, PM; van Boxtel, MPJ; van der Kallen, CJH; van Greevenbroek, MMJ; Verhey, FRJ; Wesselius, A | 1 |
| Bi, B; Gan, G; Gao, X; Li, J; Lin, S; Liu, W; Mi, J; Shi, Z; Xu, P; Xu, X; Ye, Y; Yuan, Y; Zeng, W; Zhang, J; Zhang, N; Zhou, A | 1 |
| Bugiani, M; Dijkhuis, A; Duitman, JW; Geeraerts, Z; Guo, L; Lutter, R; Nossent, EJ; Roos, E; Schurink, B; van der Valk, P; van Vught, L; Vaz, FM; Vlaar, AP; Yeh, SR | 1 |
| Bourgeat, P; Cespedes, M; Chatterjee, P; Doecke, JD; Fowler, CJ; Guillemin, GJ; Ittner, A; Jacobs, KR; Lim, CK; Lovejoy, DB; Martins, RN; Maruff, P; Masters, CL; Pertile, KK; Rainey-Smith, SR; Rembach, A; Rowe, CC; Rumble, RL; Trounson, B; Villemagne, VL | 1 |
| Asakawa, T; Chen, W; Jia, X; Qin, W; Shi, Y | 1 |
| Antony, J; Ardern-Holmes, S; Bandodkar, S; Dale, RC; Gill, D; Guillemin, GJ; Guller, A; Gupta, S; Han, VX; Heng, B; Innes, EA; Jones, HF; Kothur, K; Menezes, MP; Mohammad, S; Patel, S; Pires, AS; Tantsis, E; Troedson, C; Tsang, E; Webster, R; Wienholt, L; Yan, J | 1 |
| Fathi, M; Hajibeygi, R; Jazi, K; Klegeris, A; McElhinney, A; Sayehmiri, F; Shool, S; Sodeifian, F; Tavasol, A; Tavirani, MR; Vakili, K; Yaghoobpoor, S | 1 |
| Baymeeva, NV; Brusov, OS; Oleichik, IV; Shilov, YE; Sizov, SV; Tyurin, IA | 1 |
5 review(s) available for kynurenine and 3-hydroxyanthranilic acid
| Article | Year |
|---|---|
The kynurenine pathway and neurologic disease. Therapeutic strategies.
Topics: 3-Hydroxyanthranilic Acid; Animals; Gerbillinae; Guinea Pigs; Humans; Kynurenine; Macrophage Activation; Mice; Nervous System Diseases; Neurotoxins; Primates; Quinolinic Acid; Rats; Spinal Cord; Spinal Cord Injuries | 1996 |
[Microanalysis of tryptophan metabolites].
Topics: 3-Hydroxyanthranilic Acid; Animals; Fluorometry; Humans; Kynurenic Acid; Kynurenine; Mice; Microchemistry; Tryptophan; Ultraviolet Rays; Urinary Bladder Neoplasms | 1997 |
The therapeutic potential of diet on immune-related diseases: based on the regulation on tryptophan metabolism.
Topics: 3-Hydroxyanthranilic Acid; Diet; Indoles; Kynurenine; Tryptophan | 2022 |
Can kynurenine pathway be considered as a next-generation therapeutic target for Parkinson's disease? An update information.
Topics: 3-Hydroxyanthranilic Acid; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Levodopa; Parkinson Disease; Quinolinic Acid; Tryptophan | 2022 |
Dynamic changes in metabolites of the kynurenine pathway in Alzheimer's disease, Parkinson's disease, and Huntington's disease: A systematic Review and meta-analysis.
Topics: 3-Hydroxyanthranilic Acid; Adenosine; Alzheimer Disease; Humans; Huntington Disease; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; NAD; Niacinamide; Parkinson Disease; Tryptophan | 2022 |
2 trial(s) available for kynurenine and 3-hydroxyanthranilic acid
| Article | Year |
|---|---|
A controlled trial of pyridoxine supplementation in children with febrile convulsions.
Topics: 3-Hydroxyanthranilic Acid; Child, Preschool; Clinical Trials as Topic; Female; Humans; Infant; Kynurenine; Male; Placebos; Pyridoxine; Recurrence; Seizures; Seizures, Febrile | 1981 |
Substrate product ratios of enzymes in the kynurenine pathway measured in plasma as indicators of functional vitamin B-6 status.
Topics: 3-Hydroxyanthranilic Acid; Aged; Aging; Biomarkers; Cross-Sectional Studies; Female; Humans; Hydrolases; Kynurenine; Longitudinal Studies; Male; Middle Aged; Norway; Pyridoxal Phosphate; Pyridoxine; ROC Curve; Transaminases; Vitamin B 6 Deficiency; Xanthurenates | 2013 |
112 other study(ies) available for kynurenine and 3-hydroxyanthranilic acid
| Article | Year |
|---|---|
[De novo biosynthesis of nicotinic acid in candida lipolytica].
Topics: 3-Hydroxyanthranilic Acid; Arylformamidase; Candida; Hydrolases; Kynurenine; Methylnitronitrosoguanidine; Mixed Function Oxygenases; Mutagens; Mutation; Nicotinic Acids; Rhodotorula; Tryptophan; Tryptophan Oxygenase | 1975 |
[Tryptophan-load in progressive scleroderma (author's transl)].
Topics: 3-Hydroxyanthranilic Acid; Female; Humans; Hydroxyindoleacetic Acid; Indoleacetic Acids; Kynurenine; Male; Niacinamide; Scleroderma, Systemic; Serotonin; Skin; Tryptamines; Tryptophan; Xanthurenates | 1976 |
Inducible and constitutive kynureninases. Control of the inducible enzyme activity by transamination and inhibition of the constitutive enzyme by 3-hydroxyanthranilate.
Topics: 3-Hydroxyanthranilic Acid; Alanine; Amino Acids; Enzyme Induction; Hydrolases; Kinetics; Kynurenine; Neurospora; Neurospora crassa; Ornithine; ortho-Aminobenzoates; Species Specificity | 1979 |
Relationship between tryptophan intake and urinary excretion of 3-hydroxy-kynurenine, 3-hydroxyanthranilic acid, xanthurenic acid and kynurenic acid.
Topics: 3-Hydroxyanthranilic Acid; Adult; Female; Humans; Kinetics; Kynurenic Acid; Kynurenine; ortho-Aminobenzoates; Tryptophan; Xanthurenates | 1979 |
A new aspect of the urinary excretion of tryptophan metabolites in patients with cancer of the bladder.
Topics: 3-Hydroxyanthranilic Acid; Adult; Aged; Aspartate Aminotransferases; Creatinine; Female; Humans; Kidney Neoplasms; Kynurenic Acid; Kynurenine; Male; Middle Aged; ortho-Aminobenzoates; Sodium; Tryptophan; Urea; Ureteral Obstruction; Urinary Bladder Neoplasms; Xanthurenates | 1978 |
Tryptophan metabolism in Japanese and British women and its relationship to endogenous steroid levels.
Topics: 3-Hydroxyanthranilic Acid; Asian People; Breast Neoplasms; Estradiol; Female; Hormones; Humans; Hydrocortisone; Japan; Kynurenine; Menopause; Tryptophan; United Kingdom; White People; Xanthurenates | 1978 |
Experimental biharzial bladder cancer: tryptophan metabolism in nonhuman primates experimentally infected with Schistosoma haematobium.
Topics: 3-Hydroxyanthranilic Acid; Animals; Disease Models, Animal; Haplorhini; Kynurenine; Liver; Neoplasms, Experimental; Papio; Schistosomiasis; Tryptophan; Tryptophan Oxygenase | 1976 |
The effect of tryptophan and a tryptophan/5-hydroxytryptophan combination on indoles in the brains of rats fed a tryptophan deficient diet.
Topics: 3-Hydroxyanthranilic Acid; 5-Hydroxytryptophan; Animals; Brain; Depression; Diet; Drug Synergism; Humans; Hydroxyindoleacetic Acid; Kynurenine; Male; Rats; Serotonin; Tryptophan; Tryptophan Oxygenase | 1975 |
A new method for determination of urinary tryptophan metabolites in bladder carcinoma.
Topics: 3-Hydroxyanthranilic Acid; Chromatography, Thin Layer; Female; Humans; Kynurenic Acid; Kynurenine; Male; Spectrometry, Fluorescence; Tryptophan; Urinary Bladder Neoplasms; Xanthurenates | 1975 |
The uptake of 14C-labeled hydroxyanthranilic acid and enantiomers of tryptophan, kynurenine, and hydroxykynurenine in human blood.
Topics: 3-Hydroxyanthranilic Acid; Adult; Female; Humans; Isomerism; Kynurenine; Middle Aged; ortho-Aminobenzoates; Scleroderma, Systemic; Tryptophan | 1975 |
Urinary tryptophan metabolites: assay of free and acid hydrolyzable conjugates of 3-hydroxykynurenine and 3-hydroxyanthranilic acid.
Topics: 3-Hydroxyanthranilic Acid; Colorimetry; Humans; Kynurenine; ortho-Aminobenzoates; Temperature; Tryptophan | 1975 |
The excretion of 3-hydroxyanthranilic acid in patients with bladder and kidney carcinoma.
Topics: 3-Hydroxyanthranilic Acid; Female; Humans; Kidney Neoplasms; Kynurenine; Male; ortho-Aminobenzoates; Urinary Bladder Neoplasms | 1975 |
Hydroxykynureninase and the excretion of 3-hydroxyanthranilate by yeast.
Topics: 3-Hydroxyanthranilic Acid; Fungi; Hydrolases; Kynurenine; ortho-Aminobenzoates; Species Specificity | 1975 |
3-Hydroxykynurenine and 3-hydroxyanthranilic acid may act as endogenous antioxidants in the eye lens.
Topics: 3-Hydroxyanthranilic Acid; Antioxidants; Crystallins; Humans; Kynurenine; Lens, Crystalline; Light | 1992 |
Evidence for the preferential production of 3-hydroxyanthranilic acid from anthranilic acid in the rat brain.
Topics: 3-Hydroxyanthranilic Acid; Animals; Brain; Kynurenine; Male; Mixed Function Oxygenases; Organ Specificity; ortho-Aminobenzoates; Rats; Rats, Inbred Strains; Tryptophan | 1991 |
Production of quinolinic acid and kynurenic acid by human glioma.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; 3-Hydroxyanthranilic Acid; Astrocytoma; Brain Neoplasms; Dioxygenases; Humans; Hydrolases; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Mixed Function Oxygenases; Neoplasm Proteins; Oxygenases; Quinolinic Acid; Quinolinic Acids | 1991 |
High-performance liquid chromatographic assay of human lymphocyte kynureninase activity levels.
Topics: 3-Hydroxyanthranilic Acid; Chromatography, High Pressure Liquid; Humans; Hydrolases; Kynurenine; Lymphocytes; Male; Nutritional Status; Pyridoxine; Substrate Specificity; Vitamin B 6 Deficiency | 1991 |
Human plasma lipofuscin melanins formed from tryptophan metabolites.
Topics: 3-Hydroxyanthranilic Acid; Adult; Chromatography, Paper; Humans; Kynurenine; Lipofuscin; Male; Melanins; Middle Aged; ortho-Aminobenzoates; Pigments, Biological; Spectrometry, Fluorescence | 1986 |
Inactivation of antiadherence effect of bladder surface glycosaminoglycans as possible mechanism for carcinogenesis.
Topics: 3-Hydroxyanthranilic Acid; Animals; Bacterial Adhesion; Cyclamates; Glycosaminoglycans; Kynurenine; Neoplasms; Rabbits; Saccharin; Urinary Bladder | 1987 |
The correlation between certain tryptophan metabolites and the N-nitrosamine content in the urine of bilharzial bladder cancer patients.
Topics: 3-Hydroxyanthranilic Acid; Adult; Aminohippuric Acids; Colorimetry; Humans; Indican; Kynurenic Acid; Kynurenine; Male; Middle Aged; Nitrosamines; ortho-Aminobenzoates; Schistosomiasis haematobia; Tryptophan; Urinary Bladder Neoplasms; Xanthurenates | 1986 |
3-Hydroxykynurenine, 3-hydroxyanthranilic acid, and o-aminophenol inhibit leucine-stimulated insulin release from rat pancreatic islets.
Topics: 3-Hydroxyanthranilic Acid; Aminophenols; Animals; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Kynurenine; Leucine; Male; ortho-Aminobenzoates; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Tryptophan | 1985 |
Reactions of oxy- and methemoglobin with tryptophan metabolites, 3-hydroxyanthranilic acid and 3-hydroxykynurenine.
Topics: 3-Hydroxyanthranilic Acid; Humans; Kinetics; Kynurenine; Methemoglobin; ortho-Aminobenzoates; Oxidation-Reduction; Oxyhemoglobins; Phytic Acid; Protein Binding; Spectrophotometry; Structure-Activity Relationship; Tryptophan | 1986 |
[Proceedings: Tryptophan metabolism, bladder carcinoma and smoking habits].
Topics: 3-Hydroxyanthranilic Acid; Carcinoma; Humans; Kynurenine; Niacinamide; Smoking; Tryptophan; Urinary Bladder Neoplasms | 1972 |
[Proceedings: Endogenous carcinogens. Experimental induction of malignant tumors and leukemias by the tryptophan metabolites 3-hydroxyanthranilic acid and 3-hydroxykynurenine].
Topics: 3-Hydroxyanthranilic Acid; Animals; Carcinoma; Kynurenine; Leukemia, Experimental; Lung Neoplasms; Mice; Neoplasms, Experimental; ortho-Aminobenzoates; Tryptophan; Urinary Bladder Neoplasms | 1972 |
[Proceedings: Tryptophan metabolism in untreated phenylketonuria and in vitamin B6 dependent cramps].
Topics: 3-Hydroxyanthranilic Acid; Adolescent; Adult; Carboxylic Acids; Child; Child, Preschool; Humans; Hydroxyquinolines; Intellectual Disability; Kynurenic Acid; Kynurenine; Muscle Cramp; Nicotinic Acids; Phenylalanine; Phenylketonurias; Tryptophan; Vitamin B 6 Deficiency; Xanthurenates | 1972 |
Comparative study of tumorigenicity in mice administered transplacentally or neonatally with metabolites of tryptophan and its related compounds.
Topics: 3-Hydroxyanthranilic Acid; Adenoma; Animals; Animals, Newborn; Carcinogens; Carcinoma, Hepatocellular; Female; Granulosa Cell Tumor; Hemangiosarcoma; Isoniazid; Kynurenine; Liver Neoplasms; Male; Maternal-Fetal Exchange; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; ortho-Aminobenzoates; Ovarian Neoplasms; Pregnancy | 1980 |
The kinetic mechanism of inhibition of liver pyridoxal kinase with tryptophan metabolites.
Topics: 3-Hydroxyanthranilic Acid; Animals; Kinetics; Kynurenine; Liver; Phosphotransferases; Pyridoxal Kinase; Quinolinic Acids; Sheep; Tryptophan; Xanthurenates | 1981 |
Alterations of the tryptophan--nicotinic acid metabolism in vitiligo.
Topics: 3-Hydroxyanthranilic Acid; Adult; Female; Humans; Hydrolases; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Male; Melanins; Mixed Function Oxygenases; Models, Biological; Niacin; Tryptophan; Vitiligo; Xanthurenates | 1982 |
The kynurenine load test, an adjunct to the tryptophan load test.
Topics: 3-Hydroxyanthranilic Acid; Aged; Female; Humans; Kynurenine; Menopause; Middle Aged; NAD; Pyridoxine; Tryptophan | 1980 |
[Effect of kynurenine and its metabolites on the vascular effects of serotonin, noradrenaline, and acetylcholine].
Topics: 3-Hydroxyanthranilic Acid; Acetylcholine; Animals; Blood Pressure; Drug Interactions; Female; Kynurenine; Norepinephrine; ortho-Aminobenzoates; Picolinic Acids; Quinolinic Acids; Rats; Serotonin | 1980 |
Hydroxykynurenine/hydroxyanthranilic acid ratios and febrile convulsions.
Topics: 3-Hydroxyanthranilic Acid; Child, Preschool; Humans; Infant; Kynurenine; ortho-Aminobenzoates; Seizures; Seizures, Febrile; Time Factors; Tryptophan | 1980 |
Metabolism of L-tryptophan to kynurenate and quinolinate in the central nervous system: effects of 6-chlorotryptophan and 4-chloro-3-hydroxyanthranilate.
Topics: 3-Hydroxyanthranilic Acid; Animals; Cell Line; Central Nervous System; Gas Chromatography-Mass Spectrometry; Humans; Kynurenic Acid; Kynurenine; Lyases; Macaca mulatta; Quinolinic Acid; Transaminases; Tryptophan | 1995 |
6-Chloro-D,L-tryptophan, 4-chloro-3-hydroxyanthranilate and dexamethasone attenuate quinolinic acid accumulation in brain and blood following systemic immune activation.
Topics: 3-Hydroxyanthranilic Acid; Animals; Brain; Dexamethasone; Immune System; Kynurenine; Lung; Male; Mice; Mice, Inbred C57BL; Pokeweed Mitogens; Quinolinic Acid; Tryptophan; Tryptophan Oxygenase | 1994 |
Metal-mediated oxidative damage to cellular and isolated DNA by certain tryptophan metabolites.
Topics: 3-Hydroxyanthranilic Acid; Animals; Autoradiography; Base Sequence; Carcinogens; Cattle; Cells, Cultured; Copper; DNA; DNA Damage; Free Radical Scavengers; Genes, ras; Humans; Indicators and Reagents; Kynurenine; Manganese Poisoning; Molecular Sequence Data; Oxidation-Reduction; Phenanthrolines; Phosphorus Radioisotopes; Spectrophotometry, Ultraviolet; Tryptophan | 1995 |
Inhibition by interferon-gamma of human mononuclear cell-mediated low density lipoprotein oxidation. Participation of tryptophan metabolism along the kynurenine pathway.
Topics: 3-Hydroxyanthranilic Acid; Cholesterol Esters; Dose-Response Relationship, Drug; Enzyme Induction; Fatty Acids, Unsaturated; Humans; Interferon-gamma; Kynurenine; Leukocytes, Mononuclear; Lipoproteins, LDL; Onium Compounds; Oxidation-Reduction; Peroxides; Tryptophan; Tryptophan Oxygenase; Vitamin E | 1994 |
Indoleamine 2,3-dioxygenase activity in the aqueous humor, iris/ciliary body, and retina of the bovine eye.
Topics: 3-Hydroxyanthranilic Acid; Animals; Aqueous Humor; Cattle; Chromatography, High Pressure Liquid; Ciliary Body; Indoleamine-Pyrrole 2,3,-Dioxygenase; Iris; Kynurenine; Retina; Tryptophan Oxygenase; Uvea | 1993 |
A mechanism of quinolinic acid formation by brain in inflammatory neurological disease. Attenuation of synthesis from L-tryptophan by 6-chlorotryptophan and 4-chloro-3-hydroxyanthranilate.
Topics: 3-Hydroxyanthranilic Acid; Animals; Biopterins; Brain; Encephalitis; Fetus; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Macaca mulatta; Myelitis; Neopterin; Poliomyelitis; Quinolinic Acid; Tryptophan; Tryptophan Oxygenase | 1993 |
The modification of proteins by 3-hydroxykynurenine.
Topics: 3-Hydroxyanthranilic Acid; Animals; Cattle; Crystallins; Cysteine; Glutathione; Hydrogen-Ion Concentration; In Vitro Techniques; Kynurenine; Oxidation-Reduction; Polylysine; Spectrophotometry; Time Factors | 1993 |
Mechanism of delayed increases in kynurenine pathway metabolism in damaged brain regions following transient cerebral ischemia.
Topics: 3-Hydroxyanthranilic Acid; Animals; Brain; Female; Gerbillinae; Immunohistochemistry; Indoleamine-Pyrrole 2,3,-Dioxygenase; Ischemic Attack, Transient; Kynurenine; Macrophages; Pokeweed Mitogens; Quinolinic Acid; Time Factors; Tryptophan; Tryptophan Oxygenase | 1993 |
4-Chloro-3-hydroxyanthranilate, 6-chlorotryptophan and norharmane attenuate quinolinic acid formation by interferon-gamma-stimulated monocytes (THP-1 cells).
Topics: 3-Hydroxyanthranilic Acid; Animals; Brain; Carbolines; Cell Line; Harmine; Humans; Interferon-gamma; Kynurenine; Leukocytes, Mononuclear; Macrophages; Quinolinic Acid; Rats; Tryptophan; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1993 |
Regulation of quinolinic acid in the normal rat brain by kynurenine pathway precursors.
Topics: 3-Hydroxyanthranilic Acid; Analysis of Variance; Animals; Cerebral Ventricles; Hippocampus; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Subcutaneous; Kynurenine; Male; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Stereoisomerism; Tryptophan | 1996 |
4-chloro-3-hydroxyanthranilate attenuate quinolinic acid accumulation in brain following transient cerebral ischemia in the gerbil.
Topics: 3-Hydroxyanthranilic Acid; Animals; Brain; Dexamethasone; Female; Gerbillinae; Ischemic Attack, Transient; Kynurenine; Organ Specificity; Quinolinic Acid; Reference Values; Tryptophan Oxygenase | 1996 |
Is an altered tryptophan metabolism responsible for age-related cataract?
Topics: 3-Hydroxyanthranilic Acid; Aged; Cataract; Chromatography, High Pressure Liquid; Female; Humans; Kynurenine; Male; Reference Values; Sensitivity and Specificity; Tryptophan | 1996 |
Relationships between methoxyindole and kynurenine pathway metabolites in plasma and urine in children suffering from febrile and epileptic seizures.
Topics: 3-Hydroxyanthranilic Acid; Child; Child, Preschool; Circadian Rhythm; Epilepsy; Female; Humans; Infant; Kynurenic Acid; Kynurenine; Male; Melatonin; Seizures, Febrile; Tryptophan; Xanthurenates | 1997 |
Effects of kynurenine metabolites on the electrocorticographic activity in the rat.
Topics: 3-Hydroxyanthranilic Acid; Animals; Biotransformation; Electroencephalography; Free Radical Scavengers; Injections, Intraventricular; Kynurenine; Male; Rats; Rats, Sprague-Dawley; Time Factors | 1998 |
Effects of oxygen on 3-hydroxyanthranilate oxidase of the kynurenine pathway.
Topics: 3-Hydroxyanthranilic Acid; Animals; Brain; Enzyme Activation; Enzyme Inhibitors; Humans; Iron; Kinetics; Kynurenine; Liver; Oxidoreductases; Oxygen; Quinolinic Acid; Rats | 1998 |
Effects of mitochondria and o-methoxybenzoylalanine on 3-hydroxyanthranilic acid dioxygenase activity and quinolinic acid synthesis.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; 3-Hydroxyanthranilic Acid; Alanine; Animals; Brain; Dioxygenases; Enzyme Inhibitors; Hydrolases; In Vitro Techniques; Kynurenine; Liver; Mice; Mitochondria; Mitochondria, Liver; N-Methylaspartate; Oxygenases; Quinolinic Acid | 1999 |
Ommochrome deficiency in an albino strain of a terrestrial isopod, Armadillidium vulgare.
Topics: 3-Hydroxyanthranilic Acid; Amino Acids; Animals; Crustacea; Female; Hydrolases; Kynurenine; Kynurenine 3-Monooxygenase; Male; Mixed Function Oxygenases; Oxazines; Phenothiazines; Phenotype; Pigmentation; Pigments, Biological; Sex Factors; Tryptophan; Tryptophan Oxygenase; Xanthenes | 1999 |
Quinolinic acid inhibits DOI-induced head shakes in mice.
Topics: 3-Hydroxyanthranilic Acid; Amphetamines; Animals; Dose-Response Relationship, Drug; Head Movements; Injections, Intraventricular; Injections, Subcutaneous; Kynurenine; Male; Mice; Quinolinic Acid; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Reflex; Serotonin Receptor Agonists | 1999 |
Cinnabarinic acid was formed in damaged mitochondria and its effect on mitochondrial respiration.
Topics: 3-Hydroxyanthranilic Acid; Amino Acids; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Kynurenine; Liver; Mice; Mice, Inbred Strains; Mitochondria, Liver; Oxazines; Oxidation-Reduction; Oxygen Consumption; Pigments, Biological; Transaminases; Xanthenes | 1999 |
L-tryptophan-kynurenine pathway metabolite 3-hydroxyanthranilic acid induces apoptosis in macrophage-derived cells under pathophysiological conditions.
Topics: 3-Hydroxyanthranilic Acid; Apoptosis; Humans; Kynurenine; Macrophages; Tryptophan; Tumor Cells, Cultured; U937 Cells | 1999 |
Involvement of tryptophan metabolism in the body color of crustacea.
Topics: 3-Hydroxyanthranilic Acid; Animals; Crustacea; Kynurenine; Mutation; Phenothiazines; Pigmentation; Pigments, Biological; Tryptophan | 1999 |
In situ produced 7-chlorokynurenate provides protection against quinolinate- and malonate-induced neurotoxicity in the rat striatum.
Topics: 3-Hydroxyanthranilic Acid; Animals; Biotransformation; Corpus Striatum; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Infusions, Parenteral; Kynurenic Acid; Kynurenine; Male; Malonates; Neurons; Neuroprotective Agents; Prodrugs; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, Glycine | 2000 |
Kynurenergic manipulations influence excitatory synaptic function and excitotoxic vulnerability in the rat hippocampus in vivo.
Topics: 3-Hydroxyanthranilic Acid; Animals; Blood-Brain Barrier; Butyrates; Enzyme Inhibitors; Hippocampus; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Male; Mixed Function Oxygenases; Neuroprotective Agents; Neurotoxins; Pyramidal Cells; Quinolinic Acid; Rats; Rats, Sprague-Dawley | 2000 |
3-Hydroxykynurenine and 3-hydroxyanthranilic acid generate hydrogen peroxide and promote alpha-crystallin cross-linking by metal ion reduction.
Topics: 3-Hydroxyanthranilic Acid; Animals; Ascorbic Acid; Cataract; Cattle; Copper; Crystallins; Electrochemistry; Humans; Hydrogen Peroxide; Iron; Kynurenine; Lens, Crystalline; Metals; Oxidation-Reduction; Superoxides; Tryptophan | 2000 |
3-Hydroxyanthranilic acid, an L-tryptophan metabolite, induces apoptosis in monocyte-derived cells stimulated by interferon-gamma.
Topics: 3-Hydroxyanthranilic Acid; Antioxidants; Apoptosis; Cell Line; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Flow Cytometry; Humans; Interferon-gamma; Kynurenine; Monocytes; Spectrophotometry; Tryptophan; Tumor Cells, Cultured; U937 Cells; Xanthine Oxidase | 2001 |
Inhibition of allogeneic T cell proliferation by indoleamine 2,3-dioxygenase-expressing dendritic cells: mediation of suppression by tryptophan metabolites.
Topics: 3-Hydroxyanthranilic Acid; Cell Death; Cell Division; Cytotoxicity Tests, Immunologic; Dendritic Cells; Gene Expression; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lymphocyte Activation; T-Lymphocytes; Time Factors; Tryptophan; Tryptophan Oxygenase | 2002 |
T cell apoptosis by tryptophan catabolism.
Topics: 3-Hydroxyanthranilic Acid; Animals; Apoptosis; Autoimmune Diseases; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases; Cell Nucleus; Cells, Cultured; Cytochrome c Group; Cytosol; Dose-Response Relationship, Drug; fas Receptor; Kynurenine; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Microscopy, Electron; Mitochondria; Quinolinic Acid; Self Tolerance; T-Lymphocytes; Th1 Cells; Thymus Gland; Tryptophan | 2002 |
Kynurenines and the respiratory parameters on rat heart mitochondria.
Topics: 3-Hydroxyanthranilic Acid; Animals; Free Radical Scavengers; In Vitro Techniques; Kinetics; Kynurenine; Male; Mitochondria, Heart; Mitochondrial Proteins; NAD; ortho-Aminobenzoates; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Succinates; Tryptophan | 2003 |
The determination in urine of some metabolites of tryptophankynurenine, anthranilic acid and 3-hydroxyanthranilic acid- and reference to the presence of o-aminophenol in urine.
Topics: 3-Hydroxyanthranilic Acid; Aminobenzoates; Aminophenols; Humans; Kynurenine; ortho-Aminobenzoates; Phenols; Tryptophan | 1959 |
METABOLISM OF 3-HYDROXYANTHRANILIC ACID-CARBOXYL-C14 IN THE HUMAN.
Topics: 3-Hydroxyanthranilic Acid; Achondroplasia; Blood; Carbon Isotopes; Chromatography; Hippurates; Humans; Kynurenic Acid; Kynurenine; Metabolism; Niacin; Niacinamide; Nicotinic Acids; ortho-Aminobenzoates; Pyridines; Rats; Research; Tryptophan; Urine; Xanthurenates | 1964 |
STUDIES ON THE METABOLISM OF THE BENZENE RING OF TRYPTOPHAN IN MAMMALIAN TISSUES. I. ENZYMIC FORMATION OF GLUTARIC ACID FROM 3-HYDROXYANTHRANILIC ACID.
Topics: 3-Hydroxyanthranilic Acid; Amino Acids; Animals; Benzene; Carbon Dioxide; Carbon Isotopes; Cats; Chromatography; Coenzyme A; Electrophoresis; Glutarates; Keto Acids; Kynurenine; Liver; Metabolism; NAD; ortho-Aminobenzoates; Pseudomonas; Pyridines; Research; Tryptophan | 1965 |
Interference of some tryptophan metabolites in the formation of melanin in vitro.
Topics: 3-Hydroxyanthranilic Acid; Agaricales; Catalysis; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; In Vitro Techniques; Kynurenine; Magnetic Resonance Spectroscopy; Melanins; Models, Chemical; Monophenol Monooxygenase; Oxygen; Pigmentation; Spectrophotometry; Time Factors; Tryptophan; Tyrosine; Ultraviolet Rays | 2004 |
Tryptophan metabolites interfere with the Ehrlich reaction used for the measurement of kynurenine.
Topics: 3-Hydroxyanthranilic Acid; Benzaldehydes; Chromatography, High Pressure Liquid; Humans; Kynurenine; Monocytes; Tryptophan | 2005 |
Reduced serotonin and 3-hydroxyanthranilic acid levels in serum of cystatin B-deficient mice, a model system for progressive myoclonus epilepsy.
Topics: 3-Hydroxyanthranilic Acid; Adult; Animals; Chromatography, High Pressure Liquid; Cystatin B; Cystatins; Disease Models, Animal; Female; Humans; Kynurenine; Male; Mice; Myoclonic Epilepsies, Progressive; Serotonin; Tryptophan | 2005 |
Differential effects of the tryptophan metabolite 3-hydroxyanthranilic acid on the proliferation of human CD8+ T cells induced by TCR triggering or homeostatic cytokines.
Topics: 3-Hydroxyanthranilic Acid; Antigen Presentation; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Cell Proliferation; Cytokines; Dendritic Cells; Free Radical Scavengers; Homeostasis; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Melanoma; Neoplasm Proteins; Receptors, Antigen, T-Cell; Tryptophan | 2006 |
Regulatory role of tryptophan degradation pathway in HLA-G expression by human monocyte-derived dendritic cells.
Topics: 3-Hydroxyanthranilic Acid; Cell Line, Tumor; Cell Separation; Dendritic Cells; Histocompatibility Antigens Class I; HLA Antigens; HLA-G Antigens; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Lipopolysaccharides; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Monocytes; Protein Processing, Post-Translational; T-Lymphocytes; Tryptophan | 2006 |
Pneumococcal meningitis causes accumulation of neurotoxic kynurenine metabolites in brain regions prone to injury.
Topics: 3-Hydroxyanthranilic Acid; Animals; Apoptosis; Brain; Disease Models, Animal; Encephalitis; Enzyme Activation; Hippocampus; Kynurenine; Kynurenine 3-Monooxygenase; Meningitis, Pneumococcal; Nerve Degeneration; Neurotoxins; Rats; Rats, Wistar; Up-Regulation | 2006 |
In vitro evidence for an antioxidant role of 3-hydroxykynurenine and 3-hydroxyanthranilic acid in the brain.
Topics: 3-Hydroxyanthranilic Acid; Animals; Antioxidants; Cerebral Cortex; Free Radical Scavengers; Kynurenine; Male; Rats; Reactive Oxygen Species; Thiobarbituric Acid Reactive Substances | 2007 |
Kynurenine pathway metabolism in patients with osteoporosis after 2 years of drug treatment.
Topics: 3-Hydroxyanthranilic Acid; Aged; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Indomethacin; Kynurenic Acid; Kynurenine; Lipid Peroxidation; Male; Middle Aged; Molecular Structure; Neopterin; ortho-Aminobenzoates; Osteoporosis; Sodium Salicylate; Tryptophan | 2006 |
Kynurenines impair energy metabolism in rat cerebral cortex.
Topics: 3-Hydroxyanthranilic Acid; Animals; Carbon Dioxide; Cerebral Cortex; Electron Transport; Energy Metabolism; Glucose; Kynurenic Acid; Kynurenine; ortho-Aminobenzoates; Rats; Rats, Wistar | 2007 |
Immunosuppressive effect of tryptophan metabolites in composite tissue allotransplantation.
Topics: 3-Hydroxyanthranilic Acid; Animals; Graft Rejection; Hindlimb; Immune Tolerance; Immunosuppressive Agents; Injections, Intramuscular; Kynurenine; Models, Animal; Rats; Rats, Inbred Lew; Tacrolimus; Tissue Transplantation; Tryptophan | 2007 |
Alterations in kynurenine precursor and product levels in schizophrenia and bipolar disorder.
Topics: 3-Hydroxyanthranilic Acid; Adult; Biomarkers; Bipolar Disorder; Brain; Chromatography, High Pressure Liquid; Female; Gyrus Cinguli; Humans; Kynurenine; Middle Aged; Niacinamide; Predictive Value of Tests; Schizophrenia; Signal Transduction; Suicide; Tryptophan; Tryptophan Oxygenase | 2008 |
NO scavenging by 3-hydroxyanthranilic acid and 3-hydroxykynurenine: N-nitrosation leads via oxadiazoles to o-quinone diazides.
Topics: 3-Hydroxyanthranilic Acid; Acetylcysteine; Aminophenols; Chromatography, Thin Layer; Diazonium Compounds; Free Radical Scavengers; Hydrazines; Inflammation; Kynurenine; Magnetic Resonance Imaging; Mass Spectrometry; Nitric Oxide; Nitrites; Nitrosation; Nuclear Magnetic Resonance, Biomolecular; ortho-Aminobenzoates; Oxadiazoles; Quinones; Tryptophan | 2008 |
5-Hydroxyanthranilic acid, a tryptophan metabolite, generates oxidative stress and neuronal death via p38 activation in cultured cerebellar granule neurones.
Topics: 3-Hydroxyanthranilic Acid; Aldosterone; Animals; Animals, Newborn; Caspase 3; Catalase; Cell Death; Cell Survival; Cells, Cultured; Cerebellum; Cycloheximide; Fluoresceins; Gene Expression Regulation, Enzymologic; Kynurenine; Neurites; Neurons; ortho-Aminobenzoates; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Protein Synthesis Inhibitors; Rats; Time Factors | 2009 |
The kynurenine pathway in adolescent depression: preliminary findings from a proton MR spectroscopy study.
Topics: 3-Hydroxyanthranilic Acid; Adolescent; Aspartic Acid; Brain; Brain Mapping; Choline; Depression; Female; Humans; Kynurenine; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Neural Pathways; Psychiatric Status Rating Scales; Statistics, Nonparametric; Tryptophan; Young Adult | 2010 |
Indoleamine 2,3-dioxigenase (IDO) is critical for host resistance against Trypanosoma cruzi.
Topics: 3-Hydroxyanthranilic Acid; Animals; Chagas Disease; Host-Parasite Interactions; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Macrophages; Mice; Trypanosoma cruzi | 2010 |
The possible role of the kynurenine pathway in adolescent depression with melancholic features.
Topics: 3-Hydroxyanthranilic Acid; Adolescent; Child; Cytokines; Depressive Disorder; Depressive Disorder, Major; Enzyme Induction; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation Mediators; Kynurenine; Male; Neurotoxins; Reference Values; Tryptophan; Young Adult | 2010 |
Insights into therapy: tryptophan oxidation and HIV infection.
Topics: 3-Hydroxyanthranilic Acid; Anti-Inflammatory Agents; Antiviral Agents; Dendritic Cells; Disease Progression; Enzyme Inhibitors; HIV Infections; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Inflammation Mediators; Interleukin-17; Kynurenine; Oxidation-Reduction; T-Lymphocytes, Helper-Inducer; T-Lymphocytes, Regulatory; Tryptophan; Viral Load | 2010 |
Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease.
Topics: 3-Hydroxyanthranilic Acid; Biopsy; CD4 Lymphocyte Count; CD4-CD8 Ratio; Cells, Cultured; Colon, Sigmoid; Dendritic Cells; Disease Progression; HIV Infections; HIV Seropositivity; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Inflammation Mediators; Interferon-gamma; Interleukin-17; Kynurenine; Lipopolysaccharides; Lymph Nodes; Prospective Studies; Rectum; T-Lymphocytes, Helper-Inducer; T-Lymphocytes, Regulatory; Time Factors; Tryptophan; Up-Regulation; Viral Load | 2010 |
The role of tryptophan catabolism along the kynurenine pathway in acute ischemic stroke.
Topics: 3-Hydroxyanthranilic Acid; Aged; Aged, 80 and over; Brain Ischemia; Free Radical Scavengers; Humans; Inflammation; Kynurenine; Male; Stroke; Tryptophan | 2010 |
3-hydroxyanthranilic acid is independently associated with monocyte chemoattractant protein-1 (CCL2) and macrophage inflammatory protein-1beta (CCL4) in patients with chronic kidney disease.
Topics: 3-Hydroxyanthranilic Acid; Adult; Aged; Atherosclerosis; Chemokine CCL2; Chemokine CCL4; Chemokines, CC; Female; Free Radical Scavengers; Humans; Kynurenine; Male; Middle Aged; Renal Insufficiency, Chronic | 2010 |
The tryptophan metabolite 3-hydroxyanthranilic acid plays anti-inflammatory and neuroprotective roles during inflammation: role of hemeoxygenase-1.
Topics: 3-Hydroxyanthranilic Acid; Adult; Animals; Anti-Inflammatory Agents; Astrocytes; Cell Death; Cells, Cultured; Chemokines; Cytokines; Heme Oxygenase-1; Humans; Interferon-gamma; Interleukin-1; Kynurenine; Mice; Microglia; Neurons; Nootropic Agents | 2011 |
Development and validation of a single analytical method for the determination of tryptophan, and its kynurenine metabolites in rat plasma.
Topics: 3-Hydroxyanthranilic Acid; Animals; Charcoal; Chromatography, High Pressure Liquid; Depression; Kynurenic Acid; Kynurenine; Linear Models; Male; ortho-Aminobenzoates; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Schizophrenia; Social Isolation; Solid Phase Extraction; Tandem Mass Spectrometry; Tryptophan | 2012 |
Systemic metabolism of tryptophan and its catabolites, kynurenine and 3-HAA, in mice with inflammatory arthritis.
Topics: 3-Hydroxyanthranilic Acid; Animals; Arthritis, Experimental; Catalysis; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Liver; Male; Mice; Tryptophan | 2013 |
An exploratory study of the interplay between decreased concentration of tryptophan, accumulation of kynurenines, and inflammatory arthritis.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; 3-Hydroxyanthranilic Acid; Animals; Arthritis, Experimental; Gene Expression Regulation; Hydrolases; Inflammation; Kynurenine; Kynurenine 3-Monooxygenase; Lymph Nodes; Mice; Mice, Inbred DBA; Organ Specificity; ortho-Aminobenzoates; RNA, Messenger; Signal Transduction; Spleen; Tryptophan | 2012 |
A community-based study on determinants of circulating markers of cellular immune activation and kynurenines: the Hordaland Health Study.
Topics: 3-Hydroxyanthranilic Acid; Aged; Aging; Biomarkers; Body Mass Index; Creatinine; Female; Humans; Inflammation; Kynurenic Acid; Kynurenine; Male; Middle Aged; Motor Activity; Neopterin; Norway; ortho-Aminobenzoates; Reference Values; Smoking; Tryptophan; Xanthurenates | 2013 |
The niacin required for optimum growth can be synthesized from L-tryptophan in growing mice lacking tryptophan-2,3-dioxygenase.
Topics: 3-Hydroxyanthranilic Acid; Animals; Body Weight; Diet; Female; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Niacin; Niacinamide; Quinolinic Acid; Tryptophan; Tryptophan Oxygenase; Xanthurenates | 2013 |
Kynurenine pathway metabolites: relevant to vitamin B-6 deficiency and beyond.
Topics: 3-Hydroxyanthranilic Acid; Female; Humans; Kynurenine; Male; Pyridoxal Phosphate; Vitamin B 6 Deficiency; Xanthurenates | 2013 |
Suppression of experimental autoimmune glomerulonephritis by tryptophan.
Topics: 3-Hydroxyanthranilic Acid; Animals; Anti-Glomerular Basement Membrane Disease; Apoptosis; CD4-Positive T-Lymphocytes; Cell Proliferation; Cells, Cultured; Cytokines; Disease Models, Animal; Female; Free Radical Scavengers; Glomerular Filtration Rate; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Macrophages; Proteinuria; Rats; Rats, Inbred WKY; Th1 Cells; Th2 Cells; Tryptophan | 2014 |
Early activation of the kynurenine pathway predicts early death and long-term outcome in patients resuscitated from out-of-hospital cardiac arrest.
Topics: 3-Hydroxyanthranilic Acid; Aged; Arterial Pressure; Cardiopulmonary Resuscitation; Chromatography, Liquid; Female; Humans; Kynurenic Acid; Kynurenine; Logistic Models; Male; Mass Spectrometry; Middle Aged; Out-of-Hospital Cardiac Arrest; Prognosis; Prospective Studies; Shock, Cardiogenic; Tryptophan | 2014 |
The urinary ratio of 3-hydroxykynurenine/3-hydroxyanthranilic acid is an index to predicting the adverse effects of D-tryptophan in rats.
Topics: 3-Hydroxyanthranilic Acid; Amino Acid Metabolism, Inborn Errors; Animals; Diet; Hydrolases; Kynurenine; Male; Rats, Wistar; Tryptophan; Weight Gain | 2014 |
Tryptophan catabolism and vitamin B-6 status are affected by gender and lifestyle factors in healthy young adults.
Topics: 3-Hydroxyanthranilic Acid; Adolescent; Adult; Arginine; Biomarkers; Dietary Supplements; Female; Healthy Volunteers; Humans; Kynurenic Acid; Kynurenine; Life Style; Male; Methionine; ortho-Aminobenzoates; Pyridoxal Phosphate; Sex Factors; Surveys and Questionnaires; Tryptophan; Vitamin B 6; Xanthurenates; Young Adult | 2015 |
Increased Plasma Levels of Xanthurenic and Kynurenic Acids in Type 2 Diabetes.
Topics: 3-Hydroxyanthranilic Acid; Adult; Aged; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenic Acid; Kynurenine; Male; Metformin; Middle Aged; Prediabetic State; Pyridoxal Phosphate; Stress, Physiological; Tryptophan; Tryptophan Oxygenase; Xanthurenates | 2015 |
Pyridoxine supplementation does not alter in vivo kinetics of one-carbon metabolism but modifies patterns of one-carbon and tryptophan metabolites in vitamin B-6-insufficient oral contraceptive users.
Topics: 3-Hydroxyanthranilic Acid; Adult; Biomarkers; Carbon; Contraceptives, Oral; Cystathionine; Dietary Supplements; Female; Glycine; Homocysteine; Humans; Kynurenine; Leucine; Methionine; Methylamines; Multivariate Analysis; Pyridoxal Phosphate; Pyridoxine; Serine; Tryptophan; Vitamin B 6 Deficiency; Young Adult | 2015 |
Elevation of Kynurenine Metabolites in Rat Liver and Serum: A Potential Additional Mechanism of the Alcohol Aversive and Anti-cancer Effects of Disulfiram?
Topics: 3-Hydroxyanthranilic Acid; Alcohol Deterrents; Animals; Chromatography, High Pressure Liquid; Disulfiram; Hydrolases; Kynurenine; Kynurenine 3-Monooxygenase; Liver; Male; Rats; Rats, Wistar; Transaminases; Tryptophan | 2016 |
Mitochondrial dysfunction related to cell damage induced by 3-hydroxykynurenine and 3-hydroxyanthranilic acid: Non-dependent-effect of early reactive oxygen species production.
Topics: 3-Hydroxyanthranilic Acid; Animals; Astrocytes; Brain; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Energy Metabolism; Free Radical Scavengers; Kynurenine; Lipid Peroxidation; Male; Membrane Potential, Mitochondrial; Mitochondrial Diseases; Oxidation-Reduction; Rats; Rats, Wistar; Reactive Oxygen Species; Stereotyped Behavior; Succinate Dehydrogenase | 2015 |
Associations between intake of fish and n-3 long-chain polyunsaturated fatty acids and plasma metabolites related to the kynurenine pathway in patients with coronary artery disease.
Topics: 3-Hydroxyanthranilic Acid; Aged; Animals; Biomarkers; Body Mass Index; Cholesterol; Coronary Artery Disease; Cross-Sectional Studies; Energy Intake; Fatty Acids, Omega-3; Female; Fishes; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Neopterin; Norway; Nutrition Assessment; ortho-Aminobenzoates; Seafood; Triglycerides; Tryptophan; Xanthurenates | 2017 |
Serum Immune System Biomarkers Neopterin and Interleukin-10 Are Strongly Related to Tryptophan Metabolism in Healthy Young Adults.
Topics: 3-Hydroxyanthranilic Acid; Adolescent; Adult; Biomarkers; Body Mass Index; C-Reactive Protein; Cross-Sectional Studies; Female; Humans; Inflammation; Interleukin-10; Kynurenine; Linear Models; Male; Neopterin; ortho-Aminobenzoates; Pyridoxal Phosphate; Surveys and Questionnaires; Tryptophan; Vitamin B 6; Young Adult | 2016 |
3-Hydroxykynurenine and 3-Hydroxyanthranilic Acid Enhance the Toxicity Induced by Copper in Rat Astrocyte Culture.
Topics: 3-Hydroxyanthranilic Acid; Animals; Astrocytes; Copper; Kynurenine; Rats | 2017 |
Kynurenine Pathway Metabolites in Alzheimer's Disease.
Topics: 3-Hydroxyanthranilic Acid; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Cognition Disorders; Cohort Studies; Female; Humans; Kynurenine; Male; Middle Aged; Neuropsychological Tests; Quinolinic Acid; Signal Transduction; Statistics, Nonparametric; Tryptophan; Xanthurenates | 2017 |
A prospective evaluation of serum kynurenine metabolites and risk of pancreatic cancer.
Topics: 3-Hydroxyanthranilic Acid; Biomarkers; Case-Control Studies; China; Female; Humans; Kynurenine; Male; Middle Aged; Odds Ratio; Pancreatic Neoplasms; Prospective Studies; Pyridoxal Phosphate; Risk Factors; Vitamin B 6 | 2018 |
Engagement of Nuclear Coactivator 7 by 3-Hydroxyanthranilic Acid Enhances Activation of Aryl Hydrocarbon Receptor in Immunoregulatory Dendritic Cells.
Topics: 3-Hydroxyanthranilic Acid; Animals; Dendritic Cells; Female; Humans; Kynurenine; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Nuclear Receptor Coactivators; Receptors, Aryl Hydrocarbon; T-Lymphocytes, Regulatory | 2019 |
Peripheral tryptophan, serotonin, kynurenine, and their metabolites in major depression: A case-control study.
Topics: 3-Hydroxyanthranilic Acid; Adult; Case-Control Studies; Cohort Studies; Depressive Disorder, Major; Female; Humans; Kynurenine; Male; Middle Aged; Niacinamide; Picolinic Acids; Serotonin; Tryptophan; Xanthurenates | 2020 |
Tryptophan metabolite concentrations in depressed patients before and after electroconvulsive therapy.
Topics: 3-Hydroxyanthranilic Acid; Affect; Case-Control Studies; Electroconvulsive Therapy; Female; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; ortho-Aminobenzoates; Picolinic Acids; Quinolinic Acid; Tryptophan; Xanthurenates | 2020 |
UPLC-Q-TOF/MS-based plasma metabolome to identify biomarkers and time of injury in traumatic brain injured rats.
Topics: 3-Hydroxyanthranilic Acid; Animals; Brain Injuries, Traumatic; Chromatography, Liquid; Citric Acid; Glycocholic Acid; Indoles; Kynurenine; Male; Mass Spectrometry; Metabolome; Metabolomics; Methionine; Propionates; Rats; Rats, Sprague-Dawley | 2021 |
Associations between plasma kynurenines and cognitive function in individuals with normal glucose metabolism, prediabetes and type 2 diabetes: the Maastricht Study.
Topics: 3-Hydroxyanthranilic Acid; Aged; Biomarkers; Blood Glucose; Cognition; Cognitive Dysfunction; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Humans; Kynurenine; Male; Middle Aged; Prediabetic State | 2021 |
Kynurenine derivative 3-HAA is an agonist ligand for transcription factor YY1.
Topics: 3-Hydroxyanthranilic Acid; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Hep G2 Cells; Humans; Kynurenine; Ligands; Liver Neoplasms; YY1 Transcription Factor | 2021 |
Indoleamine 2,3-dioxygenase (IDO)-1 and IDO-2 activity and severe course of COVID-19.
Topics: 3-Hydroxyanthranilic Acid; Adult; Aged; Apoptosis; Autopsy; Brain; COVID-19; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lung; Middle Aged; Myocardium; Prospective Studies; Quinolinic Acid; Severity of Illness Index; Tryptophan | 2022 |
Systemic perturbations of the kynurenine pathway precede progression to dementia independently of amyloid-β.
Topics: 3-Hydroxyanthranilic Acid; Alzheimer Disease; Amyloid beta-Peptides; Australia; Biomarkers; Cognitive Dysfunction; Cross-Sectional Studies; Disease Progression; Humans; Kynurenine; Neurodegenerative Diseases; Peptide Fragments; tau Proteins | 2022 |
Decreased cerebrospinal fluid kynurenic acid in epileptic spasms: A biomarker of response to corticosteroids.
Topics: 3-Hydroxyanthranilic Acid; Adrenal Cortex Hormones; Animals; Biomarkers; Chromatography, Liquid; Epilepsy; Kynurenic Acid; Kynurenine; Male; Quinolinic Acid; Spasm; Tandem Mass Spectrometry; Tryptophan | 2022 |
[Cinnabarinic acid as a potential prognostic marker of schizophrenia].
Topics: 3-Hydroxyanthranilic Acid; Female; Humans; Kynurenine; Oxazines; Prognosis; Schizophrenia | 2022 |