kynurenic acid and serine

kynurenic acid has been researched along with serine in 59 studies

Research

Studies (59)

TimeframeStudies, this research(%)All Research%
pre-19902 (3.39)18.7374
1990's36 (61.02)18.2507
2000's16 (27.12)29.6817
2010's5 (8.47)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bostock, E; Sorrels, TL1
Epstein, FH; Heyman, S; Rosen, S; Spokes, K1
Berger, TW; Thiels, E; Weisz, DJ1
Abarca, J; Bradberry, CW; Bustos, G; Forray, MI; Gysling, K; Roth, RH1
Peeters, BW; Vanderheyden, PM1
Lazarewicz, JW; Puka, M; Salińska, E1
Alesiani, M; Davolio, P; Lombardi, G; Moroni, F; Pellicciari, R; Russi, P1
Bradford, HF; Croucher, MJ1
Wayman, CP; Wilson, JF1
Peterson, SL1
Abe, K; Mizutani, A; Saito, H1
Beart, PM; Conway, EL; Manallack, DT; Mercer, LD; O'Shea, RD1
Oles, RJ; Singh, L; Tricklebank, MD1
Baimbridge, KG; Kessler, M; Lynch, G; Oliver, MW; Shacklock, JA1
Astier, H; Tapia-Arancibia, L1
Keith, R; Patel, J; Salama, A; Thompson, C; Zinkand, WC1
Brugger, F; Fagg, GE; Nassenstein-Elton, D; Olpe, HR; Pozza, MF; Wicki, U1
Ferkany, JW; Kaplita, PV1
Larson, J; Lynch, G; Oliver, MW1
Ceserani, R; Gaviraghi, G; Maraia, G; Reggiani, A1
Birch, PJ; Grossman, CJ; Hayes, AG1
Aguglia, U; Bertorelli, R; De Sarro, A; De Sarro, G; Ongini, E1
Lehmann, JC; Procureur, D; Wood, PL1
Lukasiewicz, PD; Roeder, RC1
Woodward, JJ1
Cattabeni, F; De Graan, PN; Di Luca, M; Gispen, WH; Ramakers, GM; Urban, IJ1
Hirai, H; Okada, Y1
Gebhart, GF; Kolhekar, R1
Fujita, T; Ishizaki, K; Sudoh, M; Yoon, DM; Yoon, MH; Yoshida, N1
Chalmers, JP; Kapoor, R; Kapoor, V1
Franklin, PH; Ishmael, JE; Leid, M; Murray, TF1
Han, Y; Slaughter, MM; Zhang, J1
Matoba, M; Nishikawa, T; Tomita, U1
Pittaluga, A; Raiteri, M; Vaccari, D1
Kawabe, A; Maruoka, Y; Nakamura, M; Ohno, Y; Ohtani, K; Sakamoto, H; Tamamura, C; Tanaka, H; Yasuda, H1
Daggett, LP; Deal, C; Hess, SD; Johnson, EC; Lu, CC; Veliçelebi, G1
Maruoka, Y; Nakamura, M; Ohno, Y; Otani, K; Tamamura, C; Tanaka, H; Yasuda, H1
Ivanovic, A; Kuhse, J; Laube, B; Reiländer, H1
Hicks, TP; Ito, K1
Bergeron, R; Krasteniakov, NV; Martina, M2
Furukawa, H; Gouaux, E1
Attwell, D; Billups, D1
Johnson, MS; Moretti, L; Pentikäinen, OT; Settimo, L1
Concas, A; Marino, G; Minei, R; Pierobon, P; Porcu, P; Sogliano, C; Tino, A; Tortiglione, C1
Qiao, H; Wen, L; Yang, S; Zhang, Y; Zhou, W1
Lamas, M; Lee-Rivera, I; López-Colomé, AM1
Cao, H; Guo, JD; Ji, RR; Ren, WH; Sha, H; Wang, H; Wang, PF; Zhang, YQ; Zhao, ZQ1
Bittencourt, AS; Carobrez, AP; Santos, P; Schenberg, LC1
Solís, JM; Suárez, LM1
Akaike, A; Hama, Y; Katsuki, H; Kume, T; Suminaka, C; Tochikawa, Y1
Sun, H; Wang, HL; Wang, S1
Fernandez-Espejo, E; Moreno-Paublete, R; Portavella, M; Ramiro-Fuentes, S1
de Novellis, V; Fernández-Sánchez, E; Gatta, L; Guida, F; Luongo, L; Maione, S; Marabese, I; Migliozzi, A; Palazzo, E; Rossi, C; Soukupova, M; Zafra, F1
Dai, K; Hoshikawa, M; Niwa, O; Okada, M; Saito, H; Suzuki, N; Yamamura, S1
Camp, M; Debrouse, L; Grant, SG; Gunduz-Cinar, O; Holmes, A; Hurd, B; Kiselycznyk, C; Mishina, M; Plitt, A; Todaro, A1
Chi, YY; Coats, B; da Silva, VR; Garrett, TJ; Gregory, JF; Lamers, Y; Midttun, Ø; Muller, KE; Percival, SS; Quinlivan, EP; Ralat, MA; Rios-Avila, L; Shankar, MN; Stacpoole, PW; Ueland, PM1
Acton, D; Miles, GB1
Destreel, G; Engel, D; Seutin, V1

Other Studies

59 other study(ies) available for kynurenic acid and serine

ArticleYear
Induction of feeding by 7-chlorokynurenic acid, a strychnine-insensitive glycine binding site antagonist.
    Brain research, 1992, Feb-14, Volume: 572, Issue:1-2

    Topics: Analysis of Variance; Animals; Ataxia; Dose-Response Relationship, Drug; Feeding Behavior; Glycine; Injections, Intraventricular; Kynurenic Acid; Male; Muscle Contraction; Rats; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Serine; Strychnine

1992
Mechanism of glycine protection in hypoxic injury: analogies with glycine receptor.
    Kidney international, 1992, Volume: 42, Issue:1

    Topics: Animals; Dose-Response Relationship, Drug; Glycine; Hypoxia; In Vitro Techniques; Kidney; Kynurenic Acid; Male; Perfusion; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, Neurotransmitter; Serine

1992
In vivo modulation of N-methyl-D-aspartate receptor-dependent long-term potentiation by the glycine modulatory site.
    Neuroscience, 1992, Volume: 46, Issue:3

    Topics: 2-Amino-5-phosphonovalerate; Anesthesia; Animals; Electric Stimulation; Evoked Potentials; Hippocampus; Kynurenic Acid; Male; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Serine; Synapses

1992
Regulation of excitatory amino acid release by N-methyl-D-aspartate receptors in rat striatum: in vivo microdialysis studies.
    Brain research, 1992, Jul-10, Volume: 585, Issue:1-2

    Topics: Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Corpus Striatum; Dialysis; Dizocilpine Maleate; Extracellular Space; Fluorometry; Glutamates; Glutamic Acid; Kynurenic Acid; Male; N-Methylaspartate; Perfusion; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Serine

1992
In vitro and in vivo characterization of the NMDA receptor-linked strychnine-insensitive glycine site.
    Epilepsy research, 1992, Volume: 12, Issue:2

    Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Dizocilpine Maleate; Glycine; Kynurenic Acid; Male; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures; Serine; Stereoisomerism; Strychnine

1992
Glycine enhances extracellular 45Ca2+ response to NMDA application investigated with microdialysis of rabbit hippocampus in vivo.
    Acta neurobiologiae experimentalis, 1992, Volume: 52, Issue:2

    Topics: Amino Acids; Animals; Calcium; Calcium Radioisotopes; Dialysis; Drug Synergism; Extracellular Space; Glycine; Hippocampus; Kynurenic Acid; N-Methylaspartate; Rabbits; Receptors, N-Methyl-D-Aspartate; Serine

1992
Nicotinylalanine increases the formation of kynurenic acid in the brain and antagonizes convulsions.
    Journal of neurochemistry, 1992, Volume: 59, Issue:6

    Topics: Alanine; Animals; Anticonvulsants; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Extracellular Matrix; Hippocampus; Kidney; Kynurenic Acid; Liver; Male; Niacin; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Serine; Tryptophan

1992
The influence of strychnine-insensitive glycine receptor agonists and antagonists on generalized seizure thresholds.
    Brain research, 1991, Mar-08, Volume: 543, Issue:1

    Topics: Alanine; Amygdala; Animals; Glycine; Kindling, Neurologic; Kynurenic Acid; Male; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures; Serine; Strychnine

1991
Characteristics of NMDA receptors that stimulate release of hypothalamic alpha-MSH.
    Neuroreport, 1991, Volume: 2, Issue:8

    Topics: alpha-MSH; Animals; Hypothalamus; In Vitro Techniques; Ketamine; Kinetics; Kynurenic Acid; Magnesium; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Serine

1991
Anticonvulsant drug potentiation by glycine in maximal electroshock seizures is mimicked by D-serine and antagonized by 7-chlorokynurenic acid.
    European journal of pharmacology, 1991, Jul-09, Volume: 199, Issue:3

    Topics: Animals; Anticonvulsants; Carbamazepine; Drug Synergism; Electroshock; Glycine; Kynurenic Acid; Male; Phenobarbital; Phenytoin; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures; Serine

1991
Evidence for involvement of endogenous glycine in the induction of long-term potentiation in the dentate gyrus of anesthetized rats.
    European journal of pharmacology, 1991, Dec-03, Volume: 205, Issue:3

    Topics: Anesthesia; Animals; Electric Stimulation; Glycine; Hippocampus; Kynurenic Acid; Male; Neuronal Plasticity; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Serine; Synapses; Synaptic Transmission; Time Factors

1991
Evidence for heterogenous glycine domains but conserved multiple states of the excitatory amino acid recognition site of the NMDA receptor: regional binding studies with [3H]glycine and [3H]L-glutamate.
    Experimental brain research, 1991, Volume: 86, Issue:3

    Topics: Animals; Autoradiography; Binding, Competitive; Cerebellar Cortex; Cerebral Cortex; Cycloserine; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; Kynurenic Acid; Ligands; Male; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Serine

1991
Modulation of seizure susceptibility in the mouse by the strychnine-insensitive glycine recognition site of the NMDA receptor/ion channel complex.
    British journal of pharmacology, 1990, Volume: 99, Issue:2

    Topics: Acoustic Stimulation; Animals; Aspartic Acid; Diazepam; Injections, Intraventricular; Ion Channels; Kynurenic Acid; Male; Mice; Mice, Inbred DBA; N-Methylaspartate; Pentylenetetrazole; Piperazines; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures; Serine; Strychnine

1990
The glycine site modulates NMDA-mediated changes of intracellular free calcium in cultures of hippocampal neurons.
    Neuroscience letters, 1990, Jul-03, Volume: 114, Issue:2

    Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Calcium; Cells, Cultured; Embryo, Mammalian; Glycine; Hippocampus; Ketamine; Kinetics; Kynurenic Acid; Macromolecular Substances; N-Methylaspartate; Neurons; Rats; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Serine

1990
Pharmacological properties of the NMDA receptor involved in somatostatin release from cortical neurons.
    European journal of pharmacology, 1990, Sep-21, Volume: 186, Issue:2-3

    Topics: Animals; Cells, Cultured; Cerebral Cortex; Female; Glutamates; Kainic Acid; Kynurenic Acid; Neurons; Pregnancy; Quisqualic Acid; Rats; Receptors, N-Methyl-D-Aspartate; Serine; Somatostatin; Zinc

1990
Role of glycine in the N-methyl-D-aspartate-mediated neuronal cytotoxicity.
    Journal of neurochemistry, 1990, Volume: 54, Issue:3

    Topics: Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Glycine; Kynurenic Acid; N-Methylaspartate; Neurons; Piperazines; Pyrrolidinones; Serine

1990
Modulation of the NMDA receptor by D-serine in the cortex and the spinal cord, in vitro.
    European journal of pharmacology, 1990, Nov-20, Volume: 191, Issue:1

    Topics: Animals; Cerebral Cortex; Evoked Potentials; In Vitro Techniques; Kynurenic Acid; Male; Pyrrolidinones; Rats; Receptors, N-Methyl-D-Aspartate; Serine; Spinal Cord; Strychnine; Tetrodotoxin

1990
Evidence for direct interactions between the NMDA and glycine recognition sites in brain.
    European journal of pharmacology, 1990, Mar-13, Volume: 188, Issue:2-3

    Topics: Amino Acids; Animals; Brain Chemistry; In Vitro Techniques; Kynurenic Acid; Male; Pipecolic Acids; Piperazines; Piperidines; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Serine

1990
Activation of the glycine site associated with the NMDA receptor is required for induction of LTP in neonatal hippocampus.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 1990, Volume: 8, Issue:4

    Topics: Animals; Animals, Newborn; Electric Stimulation; Electrophysiology; Glycine; Hippocampus; In Vitro Techniques; Kynurenic Acid; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Serine

1990
Effect of 7-chloro kynurenic acid on glycine modulation of the N-methyl-D-aspartate response in guinea-pig myenteric plexus.
    European journal of pharmacology, 1989, Sep-01, Volume: 168, Issue:1

    Topics: Animals; Aspartic Acid; Glycine; Guinea Pigs; In Vitro Techniques; Kynurenic Acid; Male; Myenteric Plexus; N-Methylaspartate; Serine

1989
Kynurenic acid antagonises responses to NMDA via an action at the strychnine-insensitive glycine receptor.
    European journal of pharmacology, 1988, Sep-01, Volume: 154, Issue:1

    Topics: Animals; Aspartic Acid; Dose-Response Relationship, Drug; Glycine; In Vitro Techniques; Kynurenic Acid; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, Neurotransmitter; Serine; Strychnine

1988
Excitatory amino acid neurotransmission through both NMDA and non-NMDA receptors is involved in the anticonvulsant activity of felbamate in DBA/2 mice.
    European journal of pharmacology, 1994, Sep-01, Volume: 262, Issue:1-2

    Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Binding, Competitive; Disease Models, Animal; Dose-Response Relationship, Drug; Felbamate; Female; Glycine; Injections, Intraperitoneal; Injections, Intraventricular; Kynurenic Acid; Male; Mice; Mice, Inbred DBA; N-Methylaspartate; Phenylcarbamates; Propylene Glycols; Quinoxalines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures; Serine; Stereoisomerism; Synaptic Transmission

1994
7-Chlorokynurenate prevents NMDA-induced and kainate-induced striatal lesions.
    Brain research, 1993, Aug-20, Volume: 620, Issue:1

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Diseases; Choline O-Acetyltransferase; Corpus Striatum; Dose-Response Relationship, Drug; Kainic Acid; Kynurenic Acid; Male; N-Methylaspartate; Quisqualic Acid; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Serine

1993
Evidence for glycine modulation of excitatory synaptic inputs to retinal ganglion cells.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1995, Volume: 15, Issue:6

    Topics: Ambystoma; Animals; Biological Transport; Dendrites; Dose-Response Relationship, Drug; Evoked Potentials; Glycine; In Vitro Techniques; Kinetics; Kynurenic Acid; Light; Patch-Clamp Techniques; Potassium Chloride; Receptors, N-Methyl-D-Aspartate; Retinal Ganglion Cells; Serine; Stereoisomerism; Synapses; Synaptic Transmission; Time Factors

1995
A comparison of the effects of ethanol and the competitive glycine antagonist 7-chlorokynurenic acid on N-methyl-D-aspartic acid-induced neurotransmitter release from rat hippocampal slices.
    Journal of neurochemistry, 1994, Volume: 62, Issue:3

    Topics: Animals; Dose-Response Relationship, Drug; Ethanol; Glycine; Hippocampus; In Vitro Techniques; Kynurenic Acid; Male; N-Methylaspartate; Neurotransmitter Agents; Norepinephrine; Rats; Rats, Sprague-Dawley; Serine

1994
The impaired long-term potentiation in the CA1 field of the hippocampus of cognitive deficient microencephalic rats is restored by D-serine.
    Neuroscience, 1993, Volume: 54, Issue:1

    Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Cognition Disorders; Electric Stimulation; Electrophysiology; Hippocampus; In Vitro Techniques; Kynurenic Acid; Picrotoxin; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serine; Synapses; Synaptic Transmission; Time Factors

1993
Serine released from hippocampal slices during deprivation of oxygen and glucose enhances the effects of glutamate on neuronal function.
    Neuroscience, 1993, Volume: 54, Issue:1

    Topics: Adenosine Triphosphate; Amino Acids; Animals; Dizocilpine Maleate; Glucose; Glutamates; Glutamic Acid; Guinea Pigs; Hippocampus; Hypoxia; In Vitro Techniques; Kynurenic Acid; Neurons; Phosphocreatine; Receptors, N-Methyl-D-Aspartate; Serine; Synaptic Transmission

1993
Modulation of spinal visceral nociceptive transmission by NMDA receptor activation in the rat.
    Journal of neurophysiology, 1996, Volume: 75, Issue:6

    Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Afferent Pathways; Animals; Colon; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Kynurenic Acid; Male; N-Methylaspartate; Neurons; Nociceptors; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Rectum; Serine; Skin; Spinal Cord; Synaptic Transmission

1996
Intrathecally administered NMDA receptor antagonists reduce the MAC of isoflurane in rats.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1996, Volume: 43, Issue:7

    Topics: Anesthetics, Inhalation; Animals; Excitatory Amino Acid Antagonists; Injections, Spinal; Isoflurane; Kynurenic Acid; Male; Piperazines; Pulmonary Alveoli; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Serine

1996
Altered responsiveness of medullary depressor neurones to L-glutamate and D-serine in SHR rats.
    Neuroreport, 1996, May-31, Volume: 7, Issue:8

    Topics: Animals; Blood Pressure; Glutamic Acid; Hypertension; Kynurenic Acid; Medulla Oblongata; Microinjections; Neurons; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Glycine; Serine; Stereoisomerism

1996
High level expression of the NMDAR1 glutamate receptor subunit in electroporated COS cells.
    Journal of neurochemistry, 1996, Volume: 67, Issue:4

    Topics: Animals; beta-Galactosidase; Binding, Competitive; Calcium; Cell Line; Chlorocebus aethiops; COS Cells; Electroporation; Excitatory Amino Acid Antagonists; Glycine; Humans; Kidney; Kinetics; Kynurenic Acid; Macromolecular Substances; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Fusion Proteins; Serine; Stereoisomerism; Transfection

1996
Partition of transient and sustained inhibitory glycinergic input to retinal ganglion cells.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997, May-15, Volume: 17, Issue:10

    Topics: Alanine; Ambystoma; Animals; Electrophysiology; Excitatory Amino Acid Antagonists; Glycine; Glycine Agents; Kynurenic Acid; Receptors, Glycine; Retinal Ganglion Cells; Serine; Strychnine; Synaptic Transmission; Taurine

1997
Characterization of 5,7-dichlorokynurenate-insensitive D-[3H]serine binding to synaptosomal fraction isolated from rat brain tissues.
    Journal of neurochemistry, 1997, Volume: 69, Issue:1

    Topics: Animals; Binding Sites; Binding, Competitive; Brain Chemistry; Cations; Cerebellum; Cerebral Cortex; Detergents; Excitatory Amino Acid Antagonists; Glycine; Kidney; Kynurenic Acid; Liver; Male; Octoxynol; Rats; Rats, Wistar; Serine; Subcellular Fractions; Synaptosomes; Tritium

1997
The "kynurenate test", a biochemical assay for putative cognition enhancers.
    The Journal of pharmacology and experimental therapeutics, 1997, Volume: 283, Issue:1

    Topics: Animals; Cognition; In Vitro Techniques; Kynurenic Acid; Male; Norepinephrine; Organophosphorus Compounds; Pentanoic Acids; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serine

1997
Selective depression of the spinal polysynaptic reflex by the NMDA receptor antagonists in an isolated spinal cord in vitro.
    General pharmacology, 1997, Volume: 29, Issue:4

    Topics: Animals; Depression, Chemical; Dizocilpine Maleate; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; In Vitro Techniques; Kynurenic Acid; Male; Piperazines; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reflex; Reflex, Monosynaptic; Serine; Spinal Cord; Spinal Nerve Roots; Strychnine; Valine

1997
Functional characterization of human N-methyl-D-aspartate subtype 1A/2D receptors.
    Journal of neurochemistry, 1998, Volume: 70, Issue:3

    Topics: Animals; Calcium; Cells, Cultured; DNA, Complementary; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fetus; Glutamic Acid; Glycine; Humans; Kidney; Kynurenic Acid; Membrane Potentials; Molecular Sequence Data; N-Methylaspartate; Oocytes; Patch-Clamp Techniques; Pipecolic Acids; Piperidines; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Sequence Homology, Amino Acid; Serine; Xenopus laevis

1998
Effects of the novel tricyclic quinoxalinedione derivatives, SM-18400 and its analogs, on N-methyl-D-aspartate (NMDA) receptor-mediated synaptic transmission in the isolated neonatal rat spinal cord in vitro.
    Japanese journal of pharmacology, 1998, Volume: 76, Issue:3

    Topics: Aminoquinolines; Animals; Animals, Newborn; Excitatory Amino Acid Antagonists; In Vitro Techniques; Kynurenic Acid; Male; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reflex; Serine; Spinal Cord; Synaptic Transmission

1998
Expression and initial characterization of a soluble glycine binding domain of the N-methyl-D-aspartate receptor NR1 subunit.
    The Journal of biological chemistry, 1998, Aug-07, Volume: 273, Issue:32

    Topics: Animals; Baculoviridae; Binding Sites; Binding, Competitive; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Indoles; Kynurenic Acid; Protein Binding; Protein Conformation; Receptors, N-Methyl-D-Aspartate; Recombinant Fusion Proteins; Serine; Spodoptera

1998
Effect of the glycine modulatory site of the N-methyl-D-aspartate receptor on synaptic responses in kitten visual cortex.
    Neuroscience letters, 2001, May-04, Volume: 303, Issue:2

    Topics: Animals; Binding Sites; Cats; Electric Stimulation; Excitatory Amino Acid Antagonists; Female; Glycine; Kynurenic Acid; Long-Term Potentiation; Male; Membrane Potentials; Neurons; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Serine; Synapses; Synaptic Transmission; Visual Cortex

2001
D-Serine differently modulates NMDA receptor function in rat CA1 hippocampal pyramidal cells and interneurons.
    The Journal of physiology, 2003, Apr-15, Volume: 548, Issue:Pt 2

    Topics: Animals; Axons; Electric Stimulation; Electrophysiology; Hippocampus; In Vitro Techniques; Interneurons; Kynurenic Acid; Membrane Potentials; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Serine; Tetrodotoxin

2003
Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core.
    The EMBO journal, 2003, Jun-16, Volume: 22, Issue:12

    Topics: Amino Acid Sequence; Animals; Binding Sites; Crystallography, X-Ray; Disulfides; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Kynurenic Acid; Models, Molecular; Molecular Sequence Data; Molecular Structure; Protein Binding; Protein Conformation; Protein Subunits; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Sequence Alignment; Serine

2003
Active release of glycine or D-serine saturates the glycine site of NMDA receptors at the cerebellar mossy fibre to granule cell synapse.
    The European journal of neuroscience, 2003, Volume: 18, Issue:11

    Topics: Animals; Animals, Newborn; Binding, Competitive; Cerebellum; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; In Vitro Techniques; Kynurenic Acid; Models, Biological; Nerve Fibers; Neurons; Patch-Clamp Techniques; Rats; Receptors, N-Methyl-D-Aspartate; Serine

2003
Model structures of the N-methyl-D-aspartate receptor subunit NR1 explain the molecular recognition of agonist and antagonist ligands.
    Journal of structural biology, 2004, Volume: 145, Issue:3

    Topics: Alanine; Amino Acid Sequence; Animals; Bacterial Proteins; Binding Sites; Crystallography, X-Ray; Cycloserine; Databases as Topic; Escherichia coli; Excitatory Amino Acid Antagonists; Glycine; Humans; Hydrogen Bonding; Indoles; Kynurenic Acid; Ligands; Mice; Models, Chemical; Models, Molecular; Molecular Sequence Data; Potassium Channels; Proline; Protein Binding; Protein Conformation; Protein Isoforms; Protein Structure, Tertiary; Rats; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Sequence Homology, Amino Acid; Serine; Threonine; Tryptophan; Water

2004
Putative NMDA receptors in Hydra: a biochemical and functional study.
    The European journal of neuroscience, 2004, Volume: 20, Issue:10

    Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Binding Sites; Cell Membrane; Concanavalin A; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Feeding Behavior; Glutamic Acid; Glutathione; Glycine; Hydra; Kynurenic Acid; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Serine; Strychnine

2004
D-serine enhances impaired long-term potentiation in CA1 subfield of hippocampal slices from aged senescence-accelerated mouse prone/8.
    Neuroscience letters, 2005, Apr-29, Volume: 379, Issue:1

    Topics: Age Factors; Aging; Analysis of Variance; Animals; D-Amino-Acid Oxidase; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Kynurenic Acid; Long-Term Potentiation; Mice; Mice, Neurologic Mutants; Serine; Valine

2005
Role of the glycine site of the N-methyl-D-aspartate receptor in synaptic plasticity induced by pairing.
    The European journal of neuroscience, 2005, Volume: 21, Issue:10

    Topics: Afferent Pathways; Animals; Electric Stimulation; Excitatory Postsynaptic Potentials; Glycine; Hippocampus; Kynurenic Acid; Long-Term Potentiation; Neuronal Plasticity; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Serine; Synapses

2005
Cell-specific expression of N-methyl-D-aspartate receptor subunits in Müller glia and neurons from the chick retina.
    Investigative ophthalmology & visual science, 2005, Volume: 46, Issue:10

    Topics: Animals; Blotting, Western; Cells, Cultured; Chick Embryo; Glycine; Isoenzymes; Kynurenic Acid; Neuroglia; Neurons; Radioligand Assay; Receptors, N-Methyl-D-Aspartate; Retina; Reverse Transcriptase Polymerase Chain Reaction; Serine; Spermine; Synaptic Membranes

2005
Is endogenous D-serine in the rostral anterior cingulate cortex necessary for pain-related negative affect?
    Journal of neurochemistry, 2006, Volume: 96, Issue:6

    Topics: Animals; Anxiety; D-Amino-Acid Oxidase; Excitatory Amino Acid Antagonists; Fear; Glycine; Gyrus Cinguli; Kynurenic Acid; Male; Membrane Potentials; N-Methylaspartate; Organ Culture Techniques; Pain; Pain Measurement; Pain Threshold; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Serine; Stress, Psychological; Synaptic Transmission

2006
Elevated T-maze evaluation of anxiety and memory effects of NMDA/glycine-B site ligands injected into the dorsal periaqueductal gray matter and the superior colliculus of rats.
    Neuropharmacology, 2006, Volume: 51, Issue:2

    Topics: Animals; Anxiety; Glycine; Kynurenic Acid; Ligands; Male; Maze Learning; Memory; Microinjections; Periaqueductal Gray; Rats; Rats, Wistar; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Serine; Stereoisomerism; Superior Colliculi

2006
Taurine potentiates presynaptic NMDA receptors in hippocampal Schaffer collateral axons.
    The European journal of neuroscience, 2006, Volume: 24, Issue:2

    Topics: Animals; Axons; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Glycine; Hippocampus; Kynurenic Acid; Male; N-Methylaspartate; Organ Culture Techniques; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Serine; Synaptic Transmission; Taurine

2006
Contribution of endogenous glycine site NMDA agonists to excitotoxic retinal damage in vivo.
    Neuroscience research, 2006, Volume: 56, Issue:3

    Topics: Amidohydrolases; Animals; Cell Death; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Kynurenic Acid; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Retinal Diseases; Retinal Ganglion Cells; Serine

2006
D-serine relieves chronic lead exposure-impaired long-term potentiation in the CA1 region of the rat hippocampus in vitro.
    Neuroscience letters, 2007, May-01, Volume: 417, Issue:2

    Topics: Animals; Chronic Disease; Environmental Exposure; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; Kynurenic Acid; Lead; Lead Poisoning, Nervous System; Long-Term Potentiation; Mossy Fibers, Hippocampal; Neuroprotective Agents; Organ Culture Techniques; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Serine

2007
Role for D-serine within the ventral tegmental area in the development of cocaine's sensitization.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2008, Volume: 33, Issue:5

    Topics: Analysis of Variance; Animals; Behavior, Animal; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Drug Administration Schedule; Gene Expression Regulation, Enzymologic; Kynurenic Acid; Male; Microinjections; Motor Activity; Neuroprotective Agents; Rats; Rats, Wistar; Serine; Time Factors; Ventral Tegmental Area

2008
Intraperiaqueductal gray glycine and D-serine exert dual effects on rostral ventromedial medulla ON- and OFF-cell activity and thermoceptive threshold in the rat.
    Journal of neurophysiology, 2009, Volume: 102, Issue:6

    Topics: Action Potentials; Animals; Dose-Response Relationship, Drug; Drug Combinations; Excitatory Amino Acid Antagonists; Glycine; Kynurenic Acid; Male; Medulla Oblongata; Microinjections; Neural Pathways; Neurons; Pain Measurement; Pain Threshold; Periaqueductal Gray; Rats; Rats, Wistar; Reaction Time; Serine; Strychnine; Tail

2009
ONO-2506 inhibits spike-wave discharges in a genetic animal model without affecting traditional convulsive tests via gliotransmission regulation.
    British journal of pharmacology, 2013, Volume: 168, Issue:5

    Topics: Animals; Anticonvulsants; Astrocytes; Caprylates; Cells, Cultured; Convulsants; Disease Models, Animal; Electroshock; Epilepsy; gamma-Aminobutyric Acid; Glutamic Acid; Kynurenic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Pentylenetetrazole; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Serine; Synaptic Transmission

2013
Probing the modulation of acute ethanol intoxication by pharmacological manipulation of the NMDAR glycine co-agonist site.
    Alcoholism, clinical and experimental research, 2013, Volume: 37, Issue:2

    Topics: Alcoholic Intoxication; Animals; Ataxia; Cycloserine; Disease Models, Animal; Disks Large Homolog 4 Protein; Dizocilpine Maleate; Drug Therapy, Combination; Glycine Plasma Membrane Transport Proteins; Guanylate Kinases; Hypothermia; Kynurenic Acid; Magnesium; Male; Membrane Proteins; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Quinolones; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Reflex, Righting; Sarcosine; Serine

2013
Metabolite profile analysis reveals functional effects of 28-day vitamin B-6 restriction on one-carbon metabolism and tryptophan catabolic pathways in healthy men and women.
    The Journal of nutrition, 2013, Volume: 143, Issue:11

    Topics: Adult; Biomarkers; Creatine; Cystathionine; Female; Humans; Inflammation; Kynurenic Acid; Kynurenine; Male; Multivariate Analysis; Postprandial Period; Pyridoxal Phosphate; Serine; Tryptophan; Vitamin B 6; Vitamin B 6 Deficiency; Young Adult

2013
Differential regulation of NMDA receptors by d-serine and glycine in mammalian spinal locomotor networks.
    Journal of neurophysiology, 2017, 05-01, Volume: 117, Issue:5

    Topics: 2-Amino-5-phosphonovalerate; Animals; Efferent Pathways; Glycine; Interneurons; Kynurenic Acid; Mice; Mice, Inbred C57BL; Motor Activity; Racemases and Epimerases; Receptors, N-Methyl-D-Aspartate; Sarcosine; Serine; Spinal Nerve Roots; Synapses

2017
Subsaturation of the N-methyl-D-aspartate receptor glycine site allows the regulation of bursting activity in juvenile rat nigral dopamine neurons.
    The European journal of neuroscience, 2019, Volume: 50, Issue:9

    Topics: 2-Amino-5-phosphonovalerate; Animals; Dopaminergic Neurons; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Glycine; Kynurenic Acid; Pars Compacta; Phosphinic Acids; Propanolamines; Rats; Receptors, N-Methyl-D-Aspartate; Serine

2019