kynurenic acid has been researched along with probenecid in 22 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (9.09) | 18.7374 |
| 1990's | 9 (40.91) | 18.2507 |
| 2000's | 5 (22.73) | 29.6817 |
| 2010's | 3 (13.64) | 24.3611 |
| 2020's | 3 (13.64) | 2.80 |
| Authors | Studies |
|---|---|
| Beal, MF; MacGarvey, U; Miller, JM | 1 |
| Beal, MF; Nozaki, K | 1 |
| Beal, MF; MacGarvey, U; Miller, J; Vécsei, L | 1 |
| Carlà, V; Moroni, F; Russi, P | 1 |
| Beni, M; Carlà, V; Lombardi, G; Moroni, F; Russi, P | 1 |
| Lou, GL; Pinsky, C; Sitar, DS | 1 |
| Beninger, RJ; Boegman, RJ; Jhamandas, K; Miranda, AF | 1 |
| Obrenovitch, TP; Taylor, DL; Urenjak, J; Zilkha, E | 1 |
| Beninger, RJ; Boegman, RJ; Harris, CA; Jhamandas, K; Miranda, AF; Tanguay, JJ | 1 |
| Beninger, RJ; Boegman, RJ; Jhamandas, K; Miranda, AF; Sutton, MA | 1 |
| Curtis, B; Lacey, B; Nitsos, I; Walker, DW | 1 |
| Emanuelsson, C; Erhardt, S; Geyer, M; Schwieler, L | 1 |
| Németh, H; Robotka, H; Somlai, C; Toldi, J; Vécsei, L | 1 |
| Agoston, M; Farkas, T; Gigler, G; Kis, Z; Marosi, M; Robotka, H; Rózsa, E; Sas, K; Szénási, G; Toldi, J; Vécsei, L | 1 |
| Klivenyi, P; Vamos, E; Vecsei, L; Voros, K; Zadori, D | 1 |
| Bohár, Z; Fülöp, F; Párdutz, A; Tajti, J; Toldi, J; Vámos, E; Varga, H; Vécsei, L | 1 |
| Carlà, V; Cavone, L; Cosi, C; Cozzi, A; Mannaioni, G; Maratea, D; Moroni, F; Sili, M | 1 |
| Honjo, H; Iwamoto, K; Uwai, Y | 1 |
| Vámos, E | 1 |
| Holenarsipur, VK; Humphreys, WG; Lai, Y; Mariappan, TT; Panfen, E; Shen, H; Tang, J; Zhang, Y; Zhao, X; Zheng, J | 1 |
| Hao, J; Lai, Y; Liu, R; Zhao, X | 1 |
| Prasad, B; Saradhi Mettu, V; Singh, DK; Thakur, A | 1 |
22 other study(ies) available for kynurenic acid and probenecid
| Article | Year |
|---|---|
The effect of peripheral loading with kynurenine and probenecid on extracellular striatal kynurenic acid concentrations.
Topics: Animals; Corpus Striatum; Dialysis; Extracellular Space; Kynurenic Acid; Kynurenine; Male; Nervous System; Probenecid; Rats; Rats, Sprague-Dawley | 1992 |
Neuroprotective effects of L-kynurenine on hypoxia-ischemia and NMDA lesions in neonatal rats.
Topics: Animals; Animals, Newborn; Brain Ischemia; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Kynurenic Acid; Kynurenine; N-Methylaspartate; Probenecid; Proto-Oncogene Proteins c-fos; Rats; Rats, Inbred Strains | 1992 |
Kynurenine and probenecid inhibit pentylenetetrazol- and NMDLA-induced seizures and increase kynurenic acid concentrations in the brain.
Topics: Analysis of Variance; Animals; Brain; Cerebral Cortex; Corpus Striatum; Diazepam; Dose-Response Relationship, Drug; Kynurenic Acid; Kynurenine; Male; Mice; N-Methylaspartate; Pentylenetetrazole; Probenecid; Seizures | 1992 |
Indolpyruvic acid administration increases the brain content of kynurenic acid. Is this a new avenue to modulate excitatory amino acid receptors in vivo?
Topics: Animals; Brain; Indoles; Kidney; Kynurenic Acid; Liver; Male; Myocardium; Probenecid; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Tryptophan | 1989 |
Presence of kynurenic acid in the mammalian brain.
Topics: Animals; Brain; Brain Chemistry; Brain Stem; Chromatography, High Pressure Liquid; Corpus Striatum; Frontal Lobe; Guinea Pigs; Hippocampus; Humans; Kynurenic Acid; Mice; Probenecid; Rabbits; Rats; Tissue Distribution; Tryptophan | 1988 |
Kynurenic acid distribution into brain and peripheral tissues of mice.
Topics: Animals; Brain; Female; Kynurenic Acid; Male; Mice; Probenecid; Sex Factors; Tissue Distribution | 1994 |
Protection against quinolinic acid-mediated excitotoxicity in nigrostriatal dopaminergic neurons by endogenous kynurenic acid.
Topics: Alanine; Animals; Corpus Striatum; Dopamine; Drug Combinations; Injections, Intraventricular; Kynurenic Acid; Kynurenine; Male; N-Methylaspartate; Neurons; Neurotoxins; Niacin; Probenecid; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Substantia Nigra; Tyrosine 3-Monooxygenase | 1997 |
Effects of probenecid on the elicitation of spreading depression in the rat striatum.
Topics: Animals; Cortical Spreading Depression; Electroencephalography; Excitatory Amino Acid Antagonists; Hydrogen-Ion Concentration; Kynurenic Acid; Lactic Acid; Male; Microdialysis; Neostriatum; Potassium; Probenecid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Uricosuric Agents | 1997 |
Modulation of striatal quinolinate neurotoxicity by elevation of endogenous brain kynurenic acid.
Topics: Alanine; Animals; Anticonvulsants; Corpus Striatum; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Amino Acid Antagonists; GABA Antagonists; Huntington Disease; Injections, Intraventricular; Kynurenic Acid; Kynurenine; Male; NADP; Neurons, Afferent; Niacin; Probenecid; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1998 |
Quinolinic acid lesion of the nigrostriatal pathway: effect on turning behaviour and protection by elevation of endogenous kynurenic acid in Rattus norvegicus.
Topics: Alanine; Animals; Corpus Striatum; Excitatory Amino Acid Antagonists; Hydrolases; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Male; Mixed Function Oxygenases; Motor Activity; Neurons; Neuroprotective Agents; Niacin; Parkinson Disease, Secondary; Probenecid; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Substantia Nigra; Tyrosine 3-Monooxygenase; Up-Regulation | 1999 |
Kynurenic acid in brain and cerebrospinal fluid of fetal, newborn, and adult sheep and effects of placental embolization.
Topics: Animals; Animals, Newborn; Brain; Brain Injuries; Embolism; Female; Fetal Hypoxia; Fetus; Kynurenic Acid; Placental Circulation; Pregnancy; Probenecid; Sheep | 1999 |
Endogenous kynurenic acid disrupts prepulse inhibition.
Topics: Acoustic Stimulation; Animals; Antipsychotic Agents; Brain; Brain Chemistry; Butyrates; Clozapine; Dopamine Antagonists; Dose-Response Relationship, Radiation; Drug Interactions; Haloperidol; Kynurenic Acid; Kynurenine; Male; Neural Inhibition; Probenecid; Rats; Reflex, Startle | 2004 |
Systemically administered glucosamine-kynurenic acid, but not pure kynurenic acid, is effective in decreasing the evoked activity in area CA1 of the rat hippocampus.
Topics: Action Potentials; Animals; Blood Pressure; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Amino Acid Antagonists; Glucosamine; Hippocampus; Injections, Intraperitoneal; Injections, Intravenous; Kynurenic Acid; Male; Pilot Projects; Probenecid; Pyramidal Cells; Rats; Rats, Wistar; Uricosuric Agents | 2005 |
Kynurenine diminishes the ischemia-induced histological and electrophysiological deficits in the rat hippocampus.
Topics: Adjuvants, Pharmaceutic; Animals; Chromatography, High Pressure Liquid; Disease Models, Animal; Electric Stimulation; Excitatory Amino Acid Antagonists; Hippocampus; In Vitro Techniques; Infarction, Middle Cerebral Artery; Kynurenic Acid; Kynurenine; Long-Term Potentiation; Male; Patch-Clamp Techniques; Phosphopyruvate Hydratase; Probenecid; Rats; Rats, Wistar | 2008 |
Neuroprotective effects of probenecid in a transgenic animal model of Huntington's disease.
Topics: Age Factors; Animals; Cell Count; Chromatography, High Pressure Liquid; Disease Models, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; Humans; Huntingtin Protein; Huntington Disease; Kaplan-Meier Estimate; Kynurenic Acid; Male; Mice; Mice, Transgenic; Nerve Tissue Proteins; Neuroprotective Agents; Nuclear Proteins; Probenecid; Statistics, Nonparametric; Trinucleotide Repeat Expansion | 2009 |
l-kynurenine combined with probenecid and the novel synthetic kynurenic acid derivative attenuate nitroglycerin-induced nNOS in the rat caudal trigeminal nucleus.
Topics: Animals; Central Nervous System Agents; Cervical Vertebrae; Drug Synergism; Kynurenic Acid; Kynurenine; Male; Nitric Oxide Donors; Nitric Oxide Synthase Type I; Nitroglycerin; Probenecid; Quinolones; Rats; Rats, Sprague-Dawley; Spinal Cord; Time Factors; Trigeminal Nuclei | 2009 |
G-protein coupled receptor 35 (GPR35) activation and inflammatory pain: Studies on the antinociceptive effects of kynurenic acid and zaprinast.
Topics: Analgesics; Animals; Antidepressive Agents, Second-Generation; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Ganglia, Spinal; Gene Expression; Inflammation; Kynurenic Acid; Kynurenine; Male; Mice; Neuroglia; Pain; Pain Measurement; Phosphodiesterase Inhibitors; Probenecid; Purinones; Receptors, G-Protein-Coupled; Spinal Cord; Tryptophan | 2011 |
Interaction and transport of kynurenic acid via human organic anion transporters hOAT1 and hOAT3.
Topics: Animals; Biological Transport; Estrone; Humans; Kinetics; Kynurenic Acid; Kynurenine; Oocytes; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Probenecid; Quinolinic Acid; Xenopus laevis | 2012 |
Protective compounds in animal models of trigeminal activation and neurodegeneration.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Drug Administration Schedule; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Humans; Kynurenic Acid; Male; Mice; Mice, Transgenic; Migraine Disorders; Neurodegenerative Diseases; Probenecid; Rats; Rats, Sprague-Dawley; Trigeminal Nerve Diseases | 2012 |
Endogenous Plasma Kynurenic Acid in Human: A Newly Discovered Biomarker for Drug-Drug Interactions Involving Organic Anion Transporter 1 and 3 Inhibition.
Topics: Adjuvants, Pharmaceutic; Biomarkers, Pharmacological; Chromatography, Liquid; Drug Interactions; Furosemide; Healthy Volunteers; Humans; Kynurenic Acid; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Probenecid; Tandem Mass Spectrometry | 2021 |
Characterization of Elimination Pathways and the Feasibility of Endogenous Metabolites as Biomarkers of Organic Anion Transporter 1/3 Inhibition in Cynomolgus Monkeys.
Topics: Animals; Biomarkers; Drug Interactions; Feasibility Studies; Homovanillic Acid; Humans; Kidney; Kynurenic Acid; Macaca fascicularis; Organic Anion Transport Protein 1; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Probenecid; Pyridoxic Acid | 2023 |
Effect of probenecid on blood levels and renal elimination of furosemide and endogenous compounds in rats: Discovery of putative organic anion transporter biomarkers.
Topics: Animals; Biomarkers; Drug Interactions; Furosemide; Kidney; Kynurenic Acid; Organic Anion Transport Protein 1; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Probenecid; Pyridoxic Acid; Rats; Renal Elimination | 2023 |