kynurenic acid has been researched along with n-methylaspartate in 220 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 41 (18.64) | 18.7374 |
| 1990's | 131 (59.55) | 18.2507 |
| 2000's | 39 (17.73) | 29.6817 |
| 2010's | 8 (3.64) | 24.3611 |
| 2020's | 1 (0.45) | 2.80 |
| Authors | Studies |
|---|---|
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Nicklas, WJ; Zeevalk, GD | 2 |
| Becker, DP; Hovda, DA; Katayama, Y; Kawamata, T; Yoshino, A | 1 |
| Di Loreto, S; Florio, T; Scarnati, E | 1 |
| Ishii, T; Masu, M; Moriyoshi, K; Nakanishi, S; Sugihara, H | 1 |
| Lu, CL; Shaikh, MB; Siegel, A | 1 |
| Pinnock, RD | 1 |
| Kita, H; Nakanishi, H; Yamamoto, K | 1 |
| Abarca, J; Bradberry, CW; Bustos, G; Forray, MI; Gysling, K; Roth, RH | 1 |
| el-Asrar, AM; Maimone, D; Morse, PH; Reder, AT; Torczynski, E | 1 |
| Henry, JL; Hong, Y | 1 |
| Gordon, FJ; Pawloski-Dahm, C | 1 |
| Lodge, D; Millar, JD; Pralong, E | 1 |
| Fink, K; Göthert, M; Schultheiss, R | 1 |
| Chapman, V; Dickenson, AH | 1 |
| Barun, S; Dalkara, T; Erdemli, G; Onur, R | 1 |
| Lazarewicz, JW; Puka, M; Salińska, E | 1 |
| Baker, R; Carling, RW; Chan, T; Foster, AC; Grimwood, S; Leeson, PD; Moore, KW; Moseley, AM; Smith, JD; Stevenson, G | 1 |
| DeFeo, PA; Hargrove, H; Patel, J; Salama, AI; Thompson, C; Zinkand, WC | 1 |
| Beal, MF; Nozaki, K | 1 |
| Beal, MF; MacGarvey, U; Miller, J; Vécsei, L | 1 |
| Wayman, CP; Wilson, JF | 1 |
| Connick, JH; Stone, TW | 1 |
| Chernevskaya, NI; Krishtal, OA; Obukhov, AG | 1 |
| Kihara, M; Kubo, T; Misu, Y | 1 |
| Kemp, JA; Priestley, T | 1 |
| Bandopadhyay, R; de Belleroche, J | 1 |
| Clark, AJ; Hastings, MH; Latimer, M; Stone, TW; Winn, P | 1 |
| Eysel, UT; FitzGibbon, T; Funke, K | 1 |
| Collins, GG | 1 |
| Delrée, P; Lefebvre, PP; Leprince, P; Moonen, G; Rigo, JM; Rogister, B; Weber, T | 1 |
| Blair, R; Woodward, JJ | 1 |
| Adams, RN; Cammack, J; Ghasemzadeh, B | 1 |
| Cherubini, E; Kilić, G; Moran, O | 1 |
| Glantz, RM; Pfeiffer-Linn, C | 1 |
| Cerne, R; Gerber, G; Randić, M | 1 |
| Christenson, J; Grillner, S | 1 |
| Oles, RJ; Singh, L; Tricklebank, MD | 1 |
| Ascher, P; Henderson, G; Johnson, JW | 1 |
| Haesslein, JL; Hunt, PF; Jouanen, A; Massardier, D; Tremblet, AM | 1 |
| Colling, JM; Robertson, SC; Talman, WT | 1 |
| Craig, CG; White, TD | 1 |
| Rasmussen, K | 1 |
| Insel, TR; Skolnick, P; Trullas, R; Winslow, JT | 1 |
| Benveniste, M; Mayer, ML; Mienville, JM; Sernagor, E | 1 |
| Okamoto, K; Sakai, Y; Sekiguchi, M | 1 |
| Baimbridge, KG; Kessler, M; Lynch, G; Oliver, MW; Shacklock, JA | 1 |
| Raigorodsky, G; Urca, G | 1 |
| Kendall, DA; Robinson, JP | 1 |
| Buchwald, NA; Cepeda, C; Dudek, FE; Kim, YI; Peacock, WJ; Tasker, JG; Walsh, JP; Wuarin, JP | 1 |
| Dingledine, R; McNamara, D | 1 |
| Chiamulera, C; Costa, S; Reggiani, A | 1 |
| Dow, KE; Riopelle, RJ | 1 |
| Keith, R; Patel, J; Salama, A; Thompson, C; Zinkand, WC | 1 |
| Pranzatelli, MR | 1 |
| Boegman, RJ; Nishimura, LM | 1 |
| Aizenman, E; Reynolds, IJ; Rush, EA | 1 |
| Calligaro, DO; Dingledine, R; McNamara, D; McQuaid, LA; O'Malley, PJ; Smith, EC | 1 |
| Colpaert, FC; Koek, W | 1 |
| Köller, H; Müller, HW; Schmalenbach, C; Siebler, M | 1 |
| Boksa, P; Kohn-Alexander, J; Mount, H; Quirion, R | 1 |
| Baron, BM; Harrison, BL; McDonald, IA; Miller, FP; Palfreyman, MG; Salituro, FG; Schmidt, CJ; Sorensen, SM; White, HS | 1 |
| Bernardi, G; Calabresi, P; De Murtas, M; Mercuri, NB | 1 |
| Gruol, DL; Joels, M; Yool, AJ | 1 |
| Ceserani, R; Gaviraghi, G; Maraia, G; Reggiani, A | 1 |
| Gallagher, JP; Lewis, MR; Phelan, KD; Shinnick-Gallagher, P | 1 |
| Dingledine, R; Kleckner, NW | 1 |
| Herberg, LJ; Rose, IC | 1 |
| Chandler, SH | 1 |
| Meguri, H; Ogita, K; Ohgaki, T; Uchida, S; Yoneda, Y | 1 |
| Harris, KM; Miller, RJ | 1 |
| Davidoff, RA; Hackman, JC; Zhang, DX | 1 |
| Gordon, FJ; Leone, C | 1 |
| Desban, M; Gauchy, C; Glowinski, J; Kemel, ML; Krebs, MO | 1 |
| Talman, WT | 1 |
| Crawford, M; Roberts, PJ | 1 |
| Johnston, MV; McDonald, JW; Silverstein, FS; Uckele, JE | 1 |
| Foster, AC; Iversen, LL; Kemp, JA; Leeson, PD; Priestley, T; Tridgett, R; Woodruff, GN | 1 |
| Birch, PJ; Grossman, CJ; Hayes, AG | 2 |
| Collins, JF; Klockgether, T; Schwarz, M; Sontag, KH; Turski, L; Turski, WA | 1 |
| Jahr, CE; Jessell, TM | 1 |
| Cotman, CW; Ganong, AH | 1 |
| Masui, H; Sato, H; Tsumoto, T | 1 |
| Curry, K; Magnuson, DS; McLennan, H; Peet, MJ | 1 |
| Barry, MJ; O'Donovan, MJ | 1 |
| Fischbach, GD; Thio, LL; Trussell, LO; Zorumski, CF | 2 |
| Dryer, SE | 1 |
| Burton, NR; Smith, DA; Stone, TW | 1 |
| Kaneko, A; Tachibana, M | 1 |
| Mayer, ML; Vyklický, L; Westbrook, GL | 1 |
| Burton, NR; Smith, DA; Stone, TW; Williams, TL | 2 |
| Massey, SC; Miller, RF | 1 |
| Hankins, MW; Ruddock, KH | 1 |
| Cherubini, E; Herrling, PL; Lanfumey, L; Stanzione, P | 1 |
| Deschenes, NL; Ransom, RW | 1 |
| Lehmann, A | 1 |
| Perkins, MN; Stone, TW | 3 |
| Cotman, CW; Ganong, AH; Lanthorn, TH | 1 |
| Schwarcz, R; Shepard, PD; Wu, HQ | 1 |
| Herrera, AJ; Osborne, NN | 1 |
| Aguglia, U; Bertorelli, R; De Sarro, A; De Sarro, G; Ongini, E | 1 |
| Anderson, LA; Kelland, MD; Soltis, RP; Walters, JR | 1 |
| Domenici, MR; Longo, R; Sagratella, S; Scotti de Carolis, A | 1 |
| Dowling, JE; Grant, GB | 1 |
| Anantharam, V; Chu, B; Treistman, SN | 1 |
| MacDonald, JF; Wang, LY | 1 |
| Eki, T; Karp, SJ; Masu, M; Nakanishi, S; Ozawa, K | 1 |
| Bessho, Y; Nakanishi, S; Nawa, H | 1 |
| Henry, JL; Radhakrishnan, V | 1 |
| Lehmann, JC; Procureur, D; Wood, PL | 1 |
| Magistretti, PJ; Pellerin, L; Stella, N | 1 |
| Chase, MH; López-Rodríguez, F; Morales, FR; Soja, PJ | 1 |
| Flores, A; Soto, E; Vega, R | 1 |
| Emre, M; Frey, P; Kelly, PH; Lowe, DA; Malanowski, J; McAllister, KH; Neijt, HC; Rüdeberg, C; Urwyler, S; White, TG | 1 |
| Becquet, D; Deprez, P; Fache, MP; Faudon, M; Giraud, P; Héry, F; Héry, M | 1 |
| Woodward, JJ | 1 |
| Eróstegui, C; Flores, A; Soto, E; Vega, R | 1 |
| Bowser-Riley, F; Davies, SN; Shuker, MA | 1 |
| Han, D; Ogita, K; Yoneda, Y | 1 |
| Carter, C; Fage, D; Voltz, C | 1 |
| Ebner, TJ; Elias, SA; Yae, H | 1 |
| Lux, HD; Parsons, CG; Zong, X | 1 |
| Abercrombie, ED; Keefe, KA; Zigmond, MJ | 1 |
| Buchwald, NA; Cohen, RW; Levine, MS; Radisavljevic, Z; Siviy, SM; Walsh, JP | 1 |
| Biella, G; Lacerenza, M; Marchettini, P; Sotgiu, ML | 1 |
| Cler, JA; Cordi, AA; Dappen, MS; Emmett, MR; Gray, NM; Iyengar, S; Mick, SJ; Monahan, JB; Rao, TS; Wood, PL | 1 |
| Aghajanian, GK; Gellman, RL | 1 |
| Heary, RF; Krieger, AJ; Maniker, AH; Sapru, HN | 1 |
| Domenici, MR; Marinelli, S; Sagratella, S | 1 |
| Pattarini, R; Pittaluga, A; Raiteri, M; Severi, P | 1 |
| Gebhart, GF; Kolhekar, R | 1 |
| Gribkoff, VK; Molinoff, PB; Zhong, J | 1 |
| Badia, A; Clos, MV; Garcia Sanz, A; Trullas, R | 1 |
| Gunasekar, PG; Kanthasamy, AG; Matsumoto, RR; Trunong, DD | 1 |
| Albuquerque, EX; Aracava, Y; Marchioro, M; Swanson, KL | 1 |
| Beninger, RJ; Boegman, RJ; Flesher, S; Jhamandas, KH; Pawley, AC | 1 |
| Erdõ, SL; Molnár, P | 1 |
| Arnolda, LF; Chalmers, JP; Llewellyn-Smith, IJ; Minson, JB; Pilowsky, PM | 1 |
| Johnson, SW; Wu, YN | 1 |
| Bonham, AC; Wilson, CG; Zhang, Z | 1 |
| Arnelle, DR; Choi, YB; D'Emilia, DM; Kim, WK; Kumar, S; Lipton, SA; Rayudu, PV; Stamler, JS | 1 |
| Beninger, RJ; Boegman, RJ; Jhamandas, K; Miranda, AF | 1 |
| Bettelini, L; Corsi, M; Fina, P; Trist, DG | 1 |
| Butterfield, BS; Grewal, RS; Stanley, BG | 1 |
| Fontana, G; Raiteri, M; Valenti, L | 1 |
| Churchill, D; Jarvis, CR; Lu, WY; MacDonald, JF; MacVicar, BA; Plant, JR; Xiong, ZG | 1 |
| Cook, JC; Gregg, AE; Sanders, BJ; Soltis, RP | 1 |
| Mancini, L; Mennini, T; Reggiani, A; Trist, D | 1 |
| Turecek, R; Vlachová, V; Vyklický, L | 1 |
| Kleinrok, Z; Kocki, T; Saran, T; Turski, WA; Urbanska, EM | 1 |
| Camarasa, J; Camins, A; Escubedo, E; Gabriel, C; Pallàs, M; Sureda, FX | 1 |
| Cugola, A; Donati, D; Micheli, F; Missio, A; Pecunioso, A; Reggiani, A; Tarzia, G | 1 |
| Chai, CY; Kuo, JS; Wang, Y; Wu, WC | 1 |
| Daggett, LP; Deal, C; Hess, SD; Johnson, EC; Lu, CC; Veliçelebi, G | 1 |
| Capdevila, JL; Fossom, LH; Skolnick, P; Trullas, R; Viu, E; Zapata, A | 1 |
| Koch, M; Kretschmer, BD | 1 |
| Guidetti, P; Poeggeler, B; Rassoulpour, A; Schwarcz, R; Wu, HQ | 1 |
| Boje, KM; Lakhman, SS | 1 |
| Roberts, A; Zhao, FY | 1 |
| Davidoff, RA; Hackman, JC; Holohean, AM | 1 |
| Abdrachmanova, G; Palecek, JI; Vlachová, V; Vyklick, L | 1 |
| Foley, CM; Hasser, EM; Hay, M; Mueller, PJ; Vogl, HW | 1 |
| Arvigo, D; Bonfanti, A; Pittaluga, A; Raiteri, M | 1 |
| Dong, LP; Wang, TY | 1 |
| Andrioli, GC; Munari, C; Pattarini, R; Pittaluga, A; Raiteri, M; Viola, C | 1 |
| Bertrand, S; Cazalets, JR | 1 |
| Legault, M; Rompré, PP; Wise, RA | 1 |
| Devau, G | 1 |
| Ceresoli-Borroni, G; Guidetti, P; Hodgkins, PS; Poeggeler, B; Rassoulpour, A; Schwarcz, R; Wu, HQ | 1 |
| Arenare, L; Battaglia, G; Bonina, F; Bruno, V; Copani, A; Ippolito, R; La Russa, M; Nicoletti, F | 1 |
| Obrenovitch, TP; Urenjak, J | 2 |
| Bunney, BS; Shi, WX; Zhang, XX | 1 |
| Arnarsson, A; Eysteinsson, T | 1 |
| Arenare, L; Battaglia, G; Boatto, G; Bonina, FP; Bruno, V; de Caprariis, P; Ippolito, R | 1 |
| Anderson, TR; Andrew, RD; Jarvis, CR | 1 |
| Gardner, EL; Hayes, RJ; Liu, X; Spector, JA; Vorel, SR | 1 |
| Floresco, SB; Grace, AA; Todd, CL | 1 |
| Albuquerque, EX; Alkondon, M; Hilmas, C; Pereira, EF; Rassoulpour, A; Schwarcz, R | 1 |
| Bains, JS; Shaw, CA | 1 |
| Feroah, TR; Forster, HV; Fuentes, CG; Hodges, M; Martino, P; Pan, L; Rice, T; Wenninger, J | 1 |
| Hisatsune, T; Kaminogawa, S; Miyakawa, N; Miyamoto, Y; Nakamura, T; Okada, H; Uchino, S; Yamashita, T | 1 |
| Bruno, JP; Kravitz, BA; Neigh-McCandless, G; Sarter, M | 1 |
| Boros, A; Dezso, P; Kolok, S; Nagy, J; Szombathelyi, Z | 1 |
| Wu, E | 1 |
| Fels, RJ; Kenney, MJ; Mendes, T; Wang, Y; Weiss, ML | 1 |
| Kocki, T; Rejdak, R; Schuettauf, F; Turski, WA; Zagorski, Z; Zarnowski, T; Zrenner, E | 1 |
| Chai, CY; Hong, LZ | 1 |
| Marszalec, W; Moriguchi, S; Narahashi, T; Yeh, JZ; Zhao, X | 1 |
| Ogonowski, AA; Smith, JB | 1 |
| Albarello, L; Capella, C; Chiaravalli, AM; Dominioni, L; Frigo, G; Giaroni, C; Lecchini, S; Zanetti, E | 1 |
| Bartolini, A; Galeotti, N; Ghelardini, C; Gualtieri, F; Manetti, D; Pittaluga, A; Pugliese, AM; Romanelli, MN | 1 |
| Rho, JM | 1 |
| Concas, A; Marino, G; Minei, R; Pierobon, P; Porcu, P; Sogliano, C; Tino, A; Tortiglione, C | 1 |
| Bhattacharyya, D; Blaise, MC; Pradhan, N; Sowdhamini, R | 1 |
| Chizh, BA; Christoph, T; Englberger, W; Reissmüller, E; Schiene, K | 1 |
| Bari, F; Busija, DW; Domoki, F; Guidetti, P; Nagy, K; Schwarcz, R | 1 |
| Bialek, M; Junemann, A; Kocki, T; Rejdak, R; Turski, WA; Zagorski, Z; Zarnowski, T; Zrenner, E | 1 |
| Cao, H; Guo, JD; Ji, RR; Ren, WH; Sha, H; Wang, H; Wang, PF; Zhang, YQ; Zhao, ZQ | 1 |
| Solís, JM; Suárez, LM | 1 |
| Akaike, A; Hama, Y; Katsuki, H; Kume, T; Suminaka, C; Tochikawa, Y | 1 |
| Guidetti, P; Poeggeler, B; Rassoulpour, A; Roberts, RC; Schwarcz, R; Wu, HQ | 1 |
| Boros, M; Erczes, D; Kaszaki, J; Palásthy, Z; Rácz, A; Torday, C; Varga, G; Vécsei, L | 1 |
| Dubrovina, NI; Zinovyev, DR; Zinovyeva, DV | 1 |
| Chen, Y; Guillemin, GJ; Meininger, V | 1 |
| Chari, M; Cheung, GW; Kokorovic, A; Lai, TY; Lam, CK; Lam, TK; Su, BB; Wang, PY; Yang, CS | 1 |
| Choragiewicz, TJ; Fiedorowicz, M; Rejdak, R; Schuettauf, F; Thaler, S; Tulidowicz-Bielak, M; Turski, WA; Zarnowski, T; Zrenner, E | 1 |
| Aiello, R; Camastra, C; Chimirri, S; Citraro, R; De Sarro, G; Donato, G; Mainardi, P; Perucca, E; Russo, E; Scicchitano, F | 1 |
| Harsing, LG; Kertesz, S; Levay, G; Matyus, P; Szabo, G; Udvari, S | 1 |
| Fontes, MA; Ianzer, D; Lima, AM; Marins, FR; Menezes, GB; Nalivaiko, E; Pedrino, GR; Vaz, G; Xavier, CH | 1 |
| Aguilera, P; Montes de Oca Balderas, P | 1 |
| Bortz, DM; Bruno, JP; Schwarcz, R; Wu, HQ | 1 |
| Biasibetti-Brendler, H; Ferreira, F; Pessoa-Pureur, R; Pierozan, P; Schmitz, F; Wyse, ATS | 1 |
| Bálint, ER; Balla, Z; Deli, MA; Fülöp, F; Fűr, G; Gácser, A; Harazin, A; Hegyi, P; Iványi, B; Kiss, L; Kormányos, ES; Kui, B; Madácsy, T; Maléth, J; Orján, EM; Papp, C; Rakonczay, Z; Tubak, V; Varga, G; Vécsei, L; Venglovecz, V | 1 |
4 review(s) available for kynurenic acid and n-methylaspartate
| Article | Year |
|---|---|
Effects of quinolinic and kynurenic acids on central neurons.
Topics: Action Potentials; Animals; Brain; Convulsants; gamma-Aminobutyric Acid; Glycine; Kynurenic Acid; Models, Neurological; N-Methylaspartate; Neurons; Quinolinic Acid; Quinolinic Acids; Rats; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Synaptic Transmission | 1991 |
Afferent effects on locus coeruleus in opiate withdrawal.
Topics: Afferent Pathways; Animals; Cats; Clonidine; Dizocilpine Maleate; Kynurenic Acid; Locus Coeruleus; Morphine; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate; Second Messenger Systems; Substance Withdrawal Syndrome | 1991 |
Excitatory amino acid transmitters in neuronal circuits of the cat visual cortex.
Topics: Acetylcholine; Animals; Aspartic Acid; Cats; Dipeptides; Evoked Potentials, Visual; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Kynurenic Acid; N-Methylaspartate; Neurons; Neurotransmitter Agents; Pipecolic Acids; Receptors, Amino Acid; Receptors, Cell Surface; Visual Cortex | 1986 |
Basic science behind the catastrophic epilepsies.
Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Corticotropin-Releasing Hormone; Epilepsies, Myoclonic; Epilepsy; Humans; Infant; Infant, Newborn; Kynurenic Acid; Kynurenine; N-Methylaspartate; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate; Serotonin; Spasms, Infantile; Tryptophan | 2004 |
216 other study(ies) available for kynurenic acid and n-methylaspartate
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Developmental differences in antagonism of NMDA toxicity by the polyamine site antagonist ifenprodil.
Topics: Amino Acids; Animals; Biogenic Polyamines; Chick Embryo; Dizocilpine Maleate; Kynurenic Acid; N-Methylaspartate; Pipecolic Acids; Piperidines; Receptors, Glutamate; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine; Retina | 1992 |
Administration of excitatory amino acid antagonists via microdialysis attenuates the increase in glucose utilization seen following concussive brain injury.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Brain; Brain Concussion; Dialysis; Energy Metabolism; Excitatory Amino Acid Antagonists; Glucose; Glutamic Acid; Ions; Kynurenic Acid; Male; N-Methylaspartate; Quinoxalines; Rats; Rats, Inbred Strains | 1992 |
Evidence that non-NMDA receptors are involved in the excitatory pathway from the pedunculopontine region to nigrostriatal dopaminergic neurons.
Topics: 2-Amino-5-phosphonovalerate; 2-Aminoadipic Acid; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Corpus Striatum; Dopamine; Electric Stimulation; Evoked Potentials; Glutamine; Iontophoresis; Kainic Acid; Kynurenic Acid; Male; N-Methylaspartate; Neurons; Pons; Quinoxalines; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Substantia Nigra; Synapses | 1992 |
Structures and properties of seven isoforms of the NMDA receptor generated by alternative splicing.
Topics: 2-Amino-5-phosphonovalerate; Amino Acid Sequence; Animals; Base Sequence; Chromosome Deletion; Cloning, Molecular; Dizocilpine Maleate; DNA; Gene Library; Kynurenic Acid; Molecular Sequence Data; N-Methylaspartate; Oocytes; Piperazines; Prosencephalon; Rats; Receptors, N-Methyl-D-Aspartate; Restriction Mapping; RNA Splicing; RNA, Messenger; Xenopus | 1992 |
Role of NMDA receptors in hypothalamic facilitation of feline defensive rage elicited from the midbrain periaqueductal gray.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids; Animals; Atropine; Cats; Female; Hypothalamus, Middle; Immunohistochemistry; Kynurenic Acid; Male; Microinjections; N-Methylaspartate; Neurotransmitter Agents; Periaqueductal Gray; Quinoxalines; Rage; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate | 1992 |
Activation of kappa-opioid receptors depresses electrically evoked excitatory postsynaptic potentials on 5-HT-sensitive neurones in the rat dorsal raphé nucleus in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Afferent Pathways; Animals; Benzofurans; Bicuculline; Bombesin; Cholecystokinin; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Evoked Potentials; Glutamates; Glutamic Acid; In Vitro Techniques; Kynurenic Acid; N-Methylaspartate; Naloxone; Naltrexone; Neurons; Picrotoxin; Prazosin; Pyrrolidines; Quinoxalines; Raphe Nuclei; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Serotonin; Synapses; Tetrodotoxin | 1992 |
Lateral hypothalamus and local stimulation induced postsynaptic responses in zona incerta neurons in an in vitro slice preparation of the rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Bicuculline; Electric Stimulation; Evoked Potentials; Hypothalamic Area, Lateral; In Vitro Techniques; Kynurenic Acid; Male; Membrane Potentials; N-Methylaspartate; Neurons; Periaqueductal Gray; Piperazines; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Synapses | 1992 |
Regulation of excitatory amino acid release by N-methyl-D-aspartate receptors in rat striatum: in vivo microdialysis studies.
Topics: Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Corpus Striatum; Dialysis; Dizocilpine Maleate; Extracellular Space; Fluorometry; Glutamates; Glutamic Acid; Kynurenic Acid; Male; N-Methylaspartate; Perfusion; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Serine | 1992 |
MK-801 protects retinal neurons from hypoxia and the toxicity of glutamate and aspartate.
Topics: Animals; Culture Techniques; Dextromethorphan; Dizocilpine Maleate; Glutamates; Glutamic Acid; Hypoxia; Kynurenic Acid; N-Methylaspartate; Neurons; Rats; Rats, Inbred Strains; Retina | 1992 |
Intrathecal administration of non-NMDA receptor agonists increases arterial pressure and heart rate in the rat.
Topics: Animals; Blood Pressure; Carbachol; Ganglia, Autonomic; Ganglionic Blockers; Glutamates; Glutamic Acid; Heart Rate; Hexamethonium; Hexamethonium Compounds; Injections, Spinal; Kainic Acid; Kynurenic Acid; Male; N-Methylaspartate; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Synaptic Transmission | 1992 |
Evidence for a kynurenate-insensitive glutamate receptor in nucleus tractus solitarii.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aorta; Blood Pressure; Cycloleucine; Electric Stimulation; Female; Heart Rate; Ibotenic Acid; Kynurenic Acid; Medulla Oblongata; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, Glutamate; Receptors, Neurotransmitter | 1992 |
Specificity and potency of N-methyl-D-aspartate glycine site antagonists and of mephenesin on the rat spinal cord in vitro.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Glycine; Ibotenic Acid; Indoles; Kynurenic Acid; Mephenesin; N-Methylaspartate; Pyrrolidinones; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1992 |
Stimulation of noradrenaline release in human cerebral cortex mediated by N-methyl-D-aspartate (NMDA) and non-NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adult; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Cerebral Cortex; Dizocilpine Maleate; Dose-Response Relationship, Drug; Female; Glycine; Humans; Ibotenic Acid; Kainic Acid; Kynurenic Acid; Magnesium; Male; N-Methylaspartate; Norepinephrine; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Tetrodotoxin; Tritium | 1992 |
The combination of NMDA antagonism and morphine produces profound antinociception in the rat dorsal horn.
Topics: Afferent Pathways; Animals; Electric Stimulation; Hot Temperature; Injections, Spinal; Kynurenic Acid; Morphine; N-Methylaspartate; Naloxone; Nerve Fibers; Neurons; Pain; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Touch | 1992 |
Glycine is required for NMDA receptor activation: electrophysiological evidence from intact rat hippocampus.
Topics: Animals; Dizocilpine Maleate; Electric Stimulation; Electrophysiology; Evoked Potentials; Glycine; Hippocampus; Iontophoresis; Ketamine; Kynurenic Acid; Magnesium; Male; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate; Time Factors | 1992 |
Glycine enhances extracellular 45Ca2+ response to NMDA application investigated with microdialysis of rabbit hippocampus in vivo.
Topics: Amino Acids; Animals; Calcium; Calcium Radioisotopes; Dialysis; Drug Synergism; Extracellular Space; Glycine; Hippocampus; Kynurenic Acid; N-Methylaspartate; Rabbits; Receptors, N-Methyl-D-Aspartate; Serine | 1992 |
4-Amido-2-carboxytetrahydroquinolines. Structure-activity relationships for antagonism at the glycine site of the NMDA receptor.
Topics: Aminoquinolines; Animals; Binding Sites; Cell Membrane; Cerebral Cortex; Glycine; Kynurenic Acid; Models, Molecular; Molecular Conformation; Molecular Structure; N-Methylaspartate; Quinolines; Rats; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 1992 |
Quisqualate neurotoxicity in rat cortical cultures: pharmacology and mechanisms.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Kynurenic Acid; N-Methylaspartate; Neurons; Quinoxalines; Quisqualic Acid; Rats; Receptors, N-Methyl-D-Aspartate | 1992 |
Neuroprotective effects of L-kynurenine on hypoxia-ischemia and NMDA lesions in neonatal rats.
Topics: Animals; Animals, Newborn; Brain Ischemia; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Kynurenic Acid; Kynurenine; N-Methylaspartate; Probenecid; Proto-Oncogene Proteins c-fos; Rats; Rats, Inbred Strains | 1992 |
Kynurenine and probenecid inhibit pentylenetetrazol- and NMDLA-induced seizures and increase kynurenic acid concentrations in the brain.
Topics: Analysis of Variance; Animals; Brain; Cerebral Cortex; Corpus Striatum; Diazepam; Dose-Response Relationship, Drug; Kynurenic Acid; Kynurenine; Male; Mice; N-Methylaspartate; Pentylenetetrazole; Probenecid; Seizures | 1992 |
Characteristics of NMDA receptors that stimulate release of hypothalamic alpha-MSH.
Topics: alpha-MSH; Animals; Hypothalamus; In Vitro Techniques; Ketamine; Kinetics; Kynurenic Acid; Magnesium; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Serine | 1991 |
NMDA receptor agonists selectively block N-type calcium channels in hippocampal neurons.
Topics: 2-Amino-5-phosphonovalerate; Adenosine; Aspartic Acid; Calcium; Calcium Channels; Glutamates; Hippocampus; Kynurenic Acid; Mollusk Venoms; N-Methylaspartate; Neuronal Plasticity; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1991 |
Ipsilateral but not contralateral blockade of excitatory amino acid receptors in the caudal ventrolateral medulla inhibits aortic baroreceptor reflex in rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aorta; Blood Pressure; Dizocilpine Maleate; Electric Stimulation; Glutamates; Glutamic Acid; Heart Rate; Kynurenic Acid; Male; Medulla Oblongata; Microinjections; Muscimol; N-Methylaspartate; Pressoreceptors; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Reflex; Synaptic Transmission | 1991 |
Effects of (+)-HA-966 and 7-chlorokynurenic acid on the kinetics of N-methyl-D-aspartate receptor agonist responses in rat cultured cortical neurons.
Topics: Animals; Binding, Competitive; Cells, Cultured; Cerebral Cortex; Glutamates; Glutamic Acid; Glycine; Kinetics; Kynurenic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Osmolar Concentration; Pyrrolidinones; Rats; Receptors, N-Methyl-D-Aspartate; Sodium | 1991 |
Regulation of CCK release in cerebral cortex by N-methyl-D-aspartate receptors: sensitivity to APV, MK-801, kynurenate, magnesium and zinc ions.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cerebral Cortex; Dizocilpine Maleate; Kainic Acid; Kynurenic Acid; Magnesium; Male; N-Methylaspartate; Potassium; Quisqualic Acid; Radioimmunoassay; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Sincalide; Zinc | 1991 |
A comparison of excitotoxic lesions of the basal forebrain by kainate, quinolinate, ibotenate, N-methyl-D-aspartate or quisqualate, and the effects on toxicity of 2-amino-5-phosphonovaleric acid and kynurenic acid in the rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Brain Diseases; Ibotenic Acid; Kainic Acid; Kynurenic Acid; Male; N-Methylaspartate; Quinolinic Acid; Quinolinic Acids; Quisqualic Acid; Rats | 1991 |
Retinogeniculate transmission by NMDA and non-NMDA receptors in the cat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cats; Geniculate Bodies; Glutamates; Glutamic Acid; Iontophoresis; Kynurenic Acid; N-Methylaspartate; Photic Stimulation; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Retina; Synaptic Transmission | 1991 |
Pharmacological evidence that NMDA receptors contribute to mono- and di-synaptic potentials in slices of mouse olfactory cortex.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cerebral Cortex; Evoked Potentials; In Vitro Techniques; Kynurenic Acid; Magnesium; Male; Mice; N-Methylaspartate; Olfactory Bulb; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Stereoisomerism; Synapses | 1991 |
Kainate and NMDA toxicity for cultured developing and adult rat spiral ganglion neurons: further evidence for a glutamatergic excitatory neurotransmission at the inner hair cell synapse.
Topics: 2-Amino-5-phosphonovalerate; Animals; Astrocytes; Cell Survival; Cells, Cultured; Cochlea; Ganglia; Glutamates; Glutamic Acid; Hair Cells, Auditory, Inner; Immunohistochemistry; In Vitro Techniques; Indicators and Reagents; Kainic Acid; Kynurenic Acid; N-Methylaspartate; Neurons, Afferent; Organ of Corti; Quisqualic Acid; Rats; Rats, Inbred Strains; Synaptic Transmission | 1991 |
Redox modulation of N-methyl-D-aspartate-stimulated neurotransmitter release from rat brain slices.
Topics: Animals; Biguanides; Brain; Disulfides; Dithionitrobenzoic Acid; Dithiothreitol; Dose-Response Relationship, Drug; In Vitro Techniques; Kynurenic Acid; Male; N-Methylaspartate; Neurotransmitter Agents; Osmolar Concentration; Oxidation-Reduction; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1991 |
The pharmacological profile of glutamate-evoked ascorbic acid efflux measured by in vivo electrochemistry.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; Animals; Ascorbic Acid; Aspartic Acid; Brain; Corpus Striatum; Electric Stimulation; Electrochemistry; Globus Pallidus; Glutamates; Glutamic Acid; Hippocampus; Kynurenic Acid; Male; Microinjections; N-Methylaspartate; Organ Specificity; Potentiometry; Rats; Rats, Inbred Strains; Stereotaxic Techniques; Thalamus | 1991 |
N-methyl-D-aspartate receptor-mediated spontaneous activity in cerebellar granule cells in culture.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Calcium Channels; Cells, Cultured; Cerebellum; Cobalt; Dizocilpine Maleate; Glutamates; Glutamic Acid; Kynurenic Acid; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Tetrodotoxin | 1991 |
An arthropod NMDA receptor.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Astacoidea; Cesium; Evoked Potentials; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Immunoenzyme Techniques; Interneurons; Kynurenic Acid; Magnesium; Membrane Potentials; N-Methylaspartate; Photic Stimulation; Receptors, N-Methyl-D-Aspartate; Vision, Ocular | 1991 |
Participation of excitatory amino acid receptors in the slow excitatory synaptic transmission in rat spinal dorsal horn.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids; Animals; Electric Stimulation; Evoked Potentials; Female; In Vitro Techniques; Kynurenic Acid; Magnesium; Male; N-Methylaspartate; Neurotransmitter Agents; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Spinal Cord; Synapses; Synaptic Transmission | 1991 |
Primary afferents evoke excitatory amino acid receptor-mediated EPSPs that are modulated by presynaptic GABAB receptors in lamprey.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Afferent Pathways; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Electric Stimulation; Evoked Potentials; gamma-Aminobutyric Acid; Ibotenic Acid; Interneurons; Kynurenic Acid; Lampreys; Mechanoreceptors; N-Methylaspartate; Quinoxalines; Receptors, GABA-A; Receptors, Neurotransmitter; Skin; Spinal Cord; Synapses; Synaptic Transmission | 1991 |
Modulation of seizure susceptibility in the mouse by the strychnine-insensitive glycine recognition site of the NMDA receptor/ion channel complex.
Topics: Acoustic Stimulation; Animals; Aspartic Acid; Diazepam; Injections, Intraventricular; Ion Channels; Kynurenic Acid; Male; Mice; Mice, Inbred DBA; N-Methylaspartate; Pentylenetetrazole; Piperazines; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures; Serine; Strychnine | 1990 |
Competitive antagonists and partial agonists at the glycine modulatory site of the mouse N-methyl-D-aspartate receptor.
Topics: Action Potentials; Animals; Brain; Cells, Cultured; Cerebral Cortex; Cycloserine; Diencephalon; Glycine; Ion Channels; Kynurenic Acid; Mice; N-Methylaspartate; Neurons; Pyrrolidinones; Receptors, N-Methyl-D-Aspartate | 1990 |
GABA release from mouse striatal neurons in primary culture as a test for the functional activity of N-methyl-D-aspartate (NMDA) antagonists.
Topics: Animals; Cells, Cultured; Corpus Striatum; Dizocilpine Maleate; Female; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Ion Channels; Kynurenic Acid; Ligands; Mice; N-Methylaspartate; Neurons; Pregnancy; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1991 |
Glycine microinjected into nucleus tractus solitarii of rat acts through cholinergic mechanisms.
Topics: Acetylcholine; Animals; Blood Pressure; Choline; Glycine; Heart Rate; Kynurenic Acid; Male; Medulla Oblongata; Microinjections; N-Methylaspartate; Physostigmine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Receptors, N-Methyl-D-Aspartate | 1991 |
Endogenous glycine modulates N-methyl-D-aspartate-evoked release of adenosine and [3H]noradrenaline from rat cortical slices.
Topics: Adenosine; Animals; Cerebral Cortex; Glycine; In Vitro Techniques; Kynurenic Acid; Male; N-Methylaspartate; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Strychnine | 1991 |
Rat pup isolation calls are reduced by functional antagonists of the NMDA receptor complex.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Amino Acids, Cyclic; Animals; Female; Glycine; Hippocampus; Kynurenic Acid; Male; N-Methylaspartate; Piperazines; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Social Isolation; Vocalization, Animal | 1990 |
Concentration-jump experiments with NMDA antagonists in mouse cultured hippocampal neurons.
Topics: 2-Amino-5-phosphonovalerate; Alanine; Animals; Aspartic Acid; Cells, Cultured; Glycine; Hippocampus; Kynurenic Acid; Mice; N-Methylaspartate; Neurons; Osmolar Concentration; Piperazines | 1990 |
Glycine-insensitive NMDA-sensitive receptor expressed in Xenopus oocytes by guinea pig cerebellar mRNA.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Cerebellum; Electric Conductivity; Female; Glycine; Guinea Pigs; Kynurenic Acid; Magnesium; Male; Membrane Potentials; N-Methylaspartate; Oocytes; Phencyclidine; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; RNA, Messenger; Xenopus laevis | 1990 |
The glycine site modulates NMDA-mediated changes of intracellular free calcium in cultures of hippocampal neurons.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Calcium; Cells, Cultured; Embryo, Mammalian; Glycine; Hippocampus; Ketamine; Kinetics; Kynurenic Acid; Macromolecular Substances; N-Methylaspartate; Neurons; Rats; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Serine | 1990 |
Spinal antinociceptive effects of excitatory amino acid antagonists: quisqualate modulates the action of N-methyl-D-aspartate.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Analgesics; Animals; Aspartic Acid; Dipeptides; Electric Stimulation; Glutamine; Kynurenic Acid; Male; Mice; Motor Activity; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spinal Cord; Vocalization, Animal | 1990 |
The glycine antagonist 7-chlorokynurenic acid blocks the effects of N-methyl-D-aspartate on agonist-stimulated phosphoinositide hydrolysis in guinea-pig brain slices.
Topics: Animals; Brain; Glutamates; Glutamic Acid; Glycine; Guinea Pigs; Hydrolysis; In Vitro Techniques; Kynurenic Acid; N-Methylaspartate; Phosphatidylinositols; Receptors, N-Methyl-D-Aspartate | 1990 |
Synaptic transmission in human neocortex removed for treatment of intractable epilepsy in children.
Topics: 2-Amino-5-phosphonovalerate; Adolescent; Bicuculline; Child; Child, Preschool; Epilepsy; Female; GABA Antagonists; Humans; Infant; Kynurenic Acid; Male; Membrane Potentials; N-Methylaspartate; Psychosurgery; Pyramidal Tracts; Spasms, Infantile; Synapses; Synaptic Transmission | 1990 |
Dual effect of glycine on NMDA-induced neurotoxicity in rat cortical cultures.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cells, Cultured; Cerebral Cortex; Drug Synergism; gamma-Aminobutyric Acid; Glycine; Kynurenic Acid; L-Lactate Dehydrogenase; N-Methylaspartate; Nerve Degeneration; Neurons; Oocytes; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Taurine; Xenopus | 1990 |
Effect of NMDA- and strychnine-insensitive glycine site antagonists on NMDA-mediated convulsions and learning.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Injections, Intraventricular; Kynurenic Acid; Learning; Male; Mice; N-Methylaspartate; Piperazines; Receptors, Glycine; Receptors, Neurotransmitter; Seizures; Strychnine | 1990 |
Ethanol inhibits NMDA-stimulated neurite growth by sensory neurons in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cells, Cultured; Chick Embryo; Ethanol; Ganglia, Spinal; Glycine; Kynurenic Acid; Magnesium; N-Methylaspartate; Neurites; Neurons, Afferent | 1990 |
Role of glycine in the N-methyl-D-aspartate-mediated neuronal cytotoxicity.
Topics: Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Glycine; Kynurenic Acid; N-Methylaspartate; Neurons; Piperazines; Pyrrolidinones; Serine | 1990 |
Antimyoclonic effect of MK-801: a possible role for NMDA receptors in developmental myoclonus of the neonatal rat.
Topics: Aminobutyrates; Analysis of Variance; Animals; Animals, Newborn; Anticonvulsants; Clonazepam; Diazepam; Dizocilpine Maleate; Dose-Response Relationship, Drug; Female; Isoxazoles; Kynurenic Acid; Male; Myoclonus; N-Methylaspartate; Quisqualic Acid; Rats; Receptors, N-Methyl-D-Aspartate; Strychnine | 1990 |
N-methyl-D-aspartate-evoked release of acetylcholine from the medial septum/diagonal band of rat brain.
Topics: Acetylcholine; Animals; Frontal Lobe; Kynurenic Acid; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Septal Nuclei | 1990 |
Reduction of NMDA receptors with dithiothreitol increases [3H]-MK-801 binding and NMDA-induced Ca2+ fluxes.
Topics: Animals; Calcium; Dithionitrobenzoic Acid; Dithiothreitol; Dizocilpine Maleate; Fluorescence; Fura-2; Glutamates; Glycine; In Vitro Techniques; Kynurenic Acid; N-Methylaspartate; Pipecolic Acids; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine | 1990 |
5,7-Dichlorokynurenic acid, a potent and selective competitive antagonist of the glycine site on NMDA receptors.
Topics: Animals; Binding, Competitive; Brain; Evoked Potentials; Female; Glycine; Kinetics; Kynurenic Acid; N-Methylaspartate; Oocytes; Rats; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Structure-Activity Relationship; Xenopus | 1990 |
Selective blockade of N-methyl-D-aspartate (NMDA)-induced convulsions by NMDA antagonists and putative glycine antagonists: relationship with phencyclidine-like behavioral effects.
Topics: Animals; Aspartic Acid; Dose-Response Relationship, Drug; Glycine; Kainic Acid; Kynurenic Acid; Male; Mice; Motor Activity; N-Methylaspartate; Oxadiazoles; Phencyclidine; Pyrrolidinones; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures | 1990 |
GABA and glutamate receptor development of cultured neurons from rat hippocampus, septal region, and neocortex.
Topics: Animals; Aspartic Acid; Cells, Cultured; Cerebral Cortex; Embryo, Mammalian; Hippocampus; Kynurenic Acid; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, Glutamate; Receptors, Neurotransmitter; Septal Nuclei | 1990 |
Subtypes of excitatory amino acid receptors involved in the stimulation of [3H]dopamine release from cell cultures of rat ventral mesencephalon.
Topics: Animals; Aspartic Acid; Cells, Cultured; Dopamine; Kynurenic Acid; Magnesium; Mesencephalon; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface | 1990 |
Activity of 5,7-dichlorokynurenic acid, a potent antagonist at the N-methyl-D-aspartate receptor-associated glycine binding site.
Topics: Animals; Calcium; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Kynurenic Acid; Male; N-Methylaspartate; Norepinephrine; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Kainic acid on neostriatal neurons intracellularly recorded in vitro: electrophysiological evidence for differential neuronal sensitivity.
Topics: Action Potentials; Animals; Cell Membrane; Corpus Striatum; Dose-Response Relationship, Drug; In Vitro Techniques; Kainic Acid; Kynurenic Acid; Male; Membrane Potentials; N-Methylaspartate; Nerve Degeneration; Neural Conduction; Neurons; Quisqualic Acid; Rats; Rats, Inbred Strains | 1990 |
Unique properties of non-N-methyl-D-aspartate excitatory responses in cultured purkinje neurons.
Topics: Action Potentials; Animals; Aspartic Acid; Cadmium; Calcium; Cations, Divalent; Choline; Electric Conductivity; Ion Channels; Kainic Acid; Kynurenic Acid; Magnesium; N-Methylaspartate; Oxadiazoles; Purkinje Cells; Quisqualic Acid; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Sodium; Sucrose; Tetrodotoxin | 1989 |
Effect of 7-chloro kynurenic acid on glycine modulation of the N-methyl-D-aspartate response in guinea-pig myenteric plexus.
Topics: Animals; Aspartic Acid; Glycine; Guinea Pigs; In Vitro Techniques; Kynurenic Acid; Male; Myenteric Plexus; N-Methylaspartate; Serine | 1989 |
Primary afferent excitatory transmission recorded intracellularly in vitro from rat medial vestibular neurons.
Topics: Action Potentials; Animals; Aspartic Acid; Electric Stimulation; In Vitro Techniques; Kynurenic Acid; Male; N-Methylaspartate; Neurons, Afferent; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Vestibular Nuclei | 1989 |
Selectivity of quinoxalines and kynurenines as antagonists of the glycine site on N-methyl-D-aspartate receptors.
Topics: Animals; Aspartic Acid; Binding Sites; Binding, Competitive; Biological Assay; Glycine; Kainic Acid; Kynurenic Acid; N-Methylaspartate; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Structure-Activity Relationship; Xenopus laevis | 1989 |
The effect of MK-801 and other antagonists of NMDA-type glutamate receptors on brain-stimulation reward.
Topics: Animals; Anticonvulsants; Aspartic Acid; Brain; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Ketamine; Kynurenic Acid; Male; N-Methylaspartate; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Self Stimulation | 1989 |
Acute excitotoxicity in chick retina caused by the unusual amino acids BOAA and BMAA: effects of MK-801 and kynurenate.
Topics: Amino Acids, Diamino; Animals; Aspartic Acid; beta-Alanine; Chick Embryo; Cyanobacteria Toxins; Dibenzocycloheptenes; Dizocilpine Maleate; gamma-Aminobutyric Acid; Glutamates; Histocytochemistry; Kynurenic Acid; N-Methylaspartate; Neurons; Neurotoxins; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Retina | 1989 |
Evidence for excitatory amino acid transmission between mesencephalic nucleus of V afferents and jaw-closer motoneurons in the guinea pig.
Topics: 2-Amino-5-phosphonovalerate; Afferent Pathways; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Dipeptides; Evoked Potentials; Guinea Pigs; Kynurenic Acid; Male; Masseter Muscle; Mesencephalon; Motor Neurons; N-Methylaspartate; Neurotransmitter Agents; Synapses; Synaptic Transmission; Trigeminal Nuclei; Valine | 1989 |
N-methyl-D-aspartate-sensitive [3H]glutamate binding sites in brain synaptic membranes treated with Triton X-100.
Topics: Amino Acids; Animals; Aspartic Acid; Binding, Competitive; Brain; Glutamates; Glutamic Acid; Kinetics; Kynurenic Acid; N-Methylaspartate; Octoxynol; Polyethylene Glycols; Quinolinic Acid; Quinolinic Acids; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Stereoisomerism; Structure-Activity Relationship; Synaptic Membranes; Temperature; Tissue Distribution | 1989 |
CNQX (6-cyano-7-nitroquinoxaline-2,3-dione) antagonizes NMDA-evoked [3H]GABA release from cultured cortical neurons via an inhibitory action at the strychnine-insensitive glycine site.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Cells, Cultured; Cerebral Cortex; gamma-Aminobutyric Acid; Glycine; Kainic Acid; Kynurenic Acid; N-Methylaspartate; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Strychnine | 1989 |
NMDA antagonists and potentiation of NMDA-induced motoneuron depolarizations in the isolated frog spinal cord.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Cell Membrane; Dibenzocycloheptenes; Dizocilpine Maleate; Drug Synergism; Evoked Potentials; Ketamine; Kynurenic Acid; Magnesium; Motor Neurons; N-Methylaspartate; Potassium; Rana pipiens; Spinal Cord; Valine | 1989 |
Is L-glutamate a neurotransmitter of baroreceptor information in the nucleus of the tractus solitarius?
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Blood Pressure; Electric Stimulation; Female; Glutamates; Heart Rate; Ibotenic Acid; Kynurenic Acid; Medulla Oblongata; N-Methylaspartate; Neurotransmitter Agents; Pressoreceptors; Rats; Reflex; Sensory Receptor Cells; Xanthurenates | 1989 |
Glycine potentiates the NMDA-induced release of dopamine through a strychnine-insensitive site in the rat striatum.
Topics: Animals; Aspartic Acid; Corpus Striatum; Dibenzocycloheptenes; Dizocilpine Maleate; Dopamine; Drug Synergism; Glycine; In Vitro Techniques; Kynurenic Acid; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Strychnine | 1989 |
Kynurenic acid microinjected into the nucleus tractus solitarius of rat blocks the arterial baroreflex but not responses to glutamate.
Topics: Acetylcholine; Animals; Arteries; Aspartic Acid; Blood Pressure; Excitatory Amino Acid Antagonists; Glutamates; Histocytochemistry; Kainic Acid; Kynurenic Acid; Male; Medulla Oblongata; Microinjections; N-Methylaspartate; Oxadiazoles; Pressoreceptors; Quisqualic Acid; Rats; Rats, Inbred Strains; Reflex | 1989 |
1-Hydroxy-3-aminopyrrolid-2-one (HA-966) and kynurenate antagonize N-methyl-D-aspartate induced enhancement of [3H]dopamine release from rat striatal slices.
Topics: Animals; Aspartic Acid; Corpus Striatum; Dopamine; Drug Antagonism; Kynurenic Acid; Male; N-Methylaspartate; Potassium; Pyrrolidinones; Rats; Rats, Inbred Strains | 1989 |
Effect of glycine and glycine receptor antagonists on NMDA-induced brain injury.
Topics: Animals; Aspartic Acid; Brain; Dose-Response Relationship, Drug; Glycine; Kynurenic Acid; N-Methylaspartate; Organ Size; Rats; Rats, Inbred Strains | 1989 |
7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex.
Topics: Animals; Animals, Newborn; Aspartic Acid; Cells, Cultured; Cerebral Cortex; Electric Conductivity; Glycine; In Vitro Techniques; Kynurenic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1988 |
Kynurenic acid antagonises responses to NMDA via an action at the strychnine-insensitive glycine receptor.
Topics: Animals; Aspartic Acid; Dose-Response Relationship, Drug; Glycine; In Vitro Techniques; Kynurenic Acid; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, Neurotransmitter; Serine; Strychnine | 1988 |
Muscle relaxant action of excitatory amino acid antagonists.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Female; Glutamates; Kynurenic Acid; Male; Muscle Relaxants, Central; Muscle Spasticity; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1985 |
Synaptic transmission between dorsal root ganglion and dorsal horn neurons in culture: antagonism of monosynaptic excitatory postsynaptic potentials and glutamate excitation by kynurenate.
Topics: Animals; Aspartic Acid; Cells, Cultured; Evoked Potentials; Female; Ganglia, Spinal; Glutamates; Glutamic Acid; Kynurenic Acid; N-Methylaspartate; Pregnancy; Rats; Spinal Cord; Synaptic Transmission | 1985 |
Kynurenic acid and quinolinic acid act at N-methyl-D-aspartate receptors in the rat hippocampus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Kynurenic Acid; Male; N-Methylaspartate; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Tetrodotoxin | 1986 |
Ca2+-dependent depolarization and burst firing of rat CA1 pyramidal neurones induced by N-methyl-D-aspartic acid and quinolinic acid: antagonism by 2-amino-5-phosphonovaleric and kynurenic acids.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Aspartic Acid; Calcium; Convulsants; Electric Conductivity; Electric Stimulation; Evoked Potentials; Hippocampus; In Vitro Techniques; Kynurenic Acid; N-Methylaspartate; Neurons; Oxadiazoles; Pyramidal Tracts; Pyridines; Quinolinic Acid; Quinolinic Acids; Quisqualic Acid; Rats; Valine | 1986 |
The effects of excitatory amino acids and their antagonists on the generation of motor activity in the isolated chick spinal cord.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Chick Embryo; Convulsants; Dipeptides; In Vitro Techniques; Kynurenic Acid; Motor Activity; Motor Neurons; N-Methylaspartate; Spinal Cord; Valine | 1987 |
Rapid desensitization of glutamate receptors in vertebrate central neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Cells, Cultured; Chick Embryo; Electric Conductivity; Hippocampus; Ibotenic Acid; In Vitro Techniques; Iontophoresis; Kynurenic Acid; N-Methylaspartate; Oxadiazoles; Pressure; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Spinal Cord; Time Factors | 1988 |
Excitatory amino acid-evoked membrane currents and excitatory synaptic transmission in lamprey reticulospinal neurons.
Topics: Amino Acids; Animals; Aspartic Acid; Brain Stem; Electric Stimulation; Evoked Potentials; Glutamates; Glutamic Acid; Kainic Acid; Kynurenic Acid; Lampreys; N-Methylaspartate; Neurons; Neurotransmitter Agents; Oxadiazoles; Quisqualic Acid; Spinal Cord; Synapses; Synaptic Transmission | 1988 |
A quantitative pharmacological analysis of some excitatory amino acid receptors in the mouse neocortex in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cerebral Cortex; Ibotenic Acid; In Vitro Techniques; Kynurenic Acid; Male; Mice; N-Methylaspartate; Quinolinic Acid; Quinolinic Acids; Receptors, Amino Acid; Receptors, Cell Surface; Valine | 1988 |
Rapid desensitization of glutamate receptors in vertebrate central neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Cells, Cultured; Chick Embryo; Electric Conductivity; Hippocampus; Ibotenic Acid; In Vitro Techniques; Iontophoresis; Kynurenic Acid; N-Methylaspartate; Oxadiazoles; Pressure; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Spinal Cord; Time Factors | 1988 |
L-glutamate-induced depolarization in solitary photoreceptors: a process that may contribute to the interaction between photoreceptors in situ.
Topics: Animals; Aspartic Acid; Axons; Dose-Response Relationship, Drug; Electric Conductivity; Glutamates; Glutamic Acid; Kainic Acid; Kynurenic Acid; Membrane Potentials; N-Methylaspartate; Oxadiazoles; Photoreceptor Cells; Quisqualic Acid; Sodium; Turtles | 1988 |
Kynurenate and FG9041 have both competitive and non-competitive antagonist actions at excitatory amino acid receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Kynurenic Acid; N-Methylaspartate; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spinal Cord | 1988 |
Sites of antagonist action on N-methyl-D-aspartic acid receptors studied using fluctuation analysis and a rapid perfusion technique.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Binding Sites; Binding, Competitive; Cations, Divalent; Cells, Cultured; Glycine; Hippocampus; Ketamine; Kynurenic Acid; Magnesium; Mice; Mice, Inbred C57BL; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine; Zinc | 1988 |
Kynurenic acid and AP5 distinguish between NMDA receptor agonists.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Dose-Response Relationship, Drug; Ibotenic Acid; Kynurenic Acid; Mice; N-Methylaspartate; Quinolinic Acid; Quinolinic Acids; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1988 |
Amino acid pharmacology in neocortical slices: evidence for bimolecular actions from an extension of the Hill and Gaddum-Schild equations.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cerebral Cortex; In Vitro Techniques; Kynurenic Acid; Mathematics; Mice; N-Methylaspartate; Pyridines; Quinolinic Acids; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1988 |
Glutamate receptors of ganglion cells in the rabbit retina: evidence for glutamate as a bipolar cell transmitter.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamates; Ibotenic Acid; Kainic Acid; Kynurenic Acid; Light; Membrane Potentials; N-Methylaspartate; Neurotransmitter Agents; Oxadiazoles; Quisqualic Acid; Rabbits; Receptors, Glutamate; Receptors, Neurotransmitter; Retina; Retinal Ganglion Cells | 1988 |
Neuropharmacological actions of kynurenic and quinolinic acids on horizontal cells of the isolated fish retina.
Topics: Animals; Aspartic Acid; Cobalt; Cyprinidae; Evoked Potentials, Visual; Kynurenic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Photic Stimulation; Pyridines; Quinolinic Acid; Quinolinic Acids; Retina | 1986 |
Excitatory amino acids in synaptic excitation of rat striatal neurones in vitro.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Aspartic Acid; Corpus Striatum; Glutamates; Glutamine; In Vitro Techniques; Kynurenic Acid; Magnesium; Membrane Potentials; N-Methylaspartate; Neurons; Rats; Synapses | 1988 |
NMDA-induced hippocampal [3H]norepinephrine release is modulated by glycine.
Topics: Animals; Aspartic Acid; Glycine; Hippocampus; In Vitro Techniques; Kynurenic Acid; N-Methylaspartate; Norepinephrine; Radioligand Assay; Rats | 1988 |
Pharmacological protection against the toxicity of N-methyl-D-aspartate in immature rat cerebellar slices.
Topics: Animals; Aspartic Acid; Aspirin; Calcium Channel Blockers; Cerebellum; Female; In Vitro Techniques; Indomethacin; Kynurenic Acid; Leupeptins; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Taurine | 1987 |
An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid.
Topics: Acetylcholine; Animals; Aspartic Acid; Cerebral Cortex; Convulsants; Drug Interactions; Kynurenic Acid; Kynurenine; Male; N-Methylaspartate; Neuromuscular Depolarizing Agents; Niacinamide; Oxadiazoles; Pyridines; Quinolinic Acid; Quinolinic Acids; Quisqualic Acid; Rats | 1982 |
Actions of excitatory amino acids and kynurenic acid in the primate hippocampus: a preliminary study.
Topics: Amino Acids; Animals; Aspartic Acid; Callitrichinae; Hippocampus; In Vitro Techniques; Kynurenic Acid; N-Methylaspartate; Oxadiazoles; Quinolinic Acid; Quinolinic Acids; Quisqualic Acid | 1984 |
Kynurenic acid inhibits synaptic and acidic amino acid-induced responses in the rat hippocampus and spinal cord.
Topics: Amino Acids; Animals; Aspartic Acid; Depression, Chemical; Hippocampus; Kynurenic Acid; Male; N-Methylaspartate; Organ Specificity; Rats; Rats, Inbred Strains; Spinal Cord; Synapses; Synaptic Transmission | 1983 |
In vivo release of [3H]-purines by quinolinic acid and related compounds.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Cerebral Cortex; Kynurenic Acid; Male; N-Methylaspartate; Purines; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Tritium | 1983 |
Excitatory amino acid-induced excitation of dopamine-containing neurons in the rat substantia nigra: modulation by kynurenic acid.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Dopamine; Electrophysiology; Extracellular Space; In Vitro Techniques; Kynurenic Acid; Magnesium; Male; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Substantia Nigra | 1994 |
The effect of experimental ischaemia and excitatory amino acid agonists on the GABA and serotonin immunoreactivities in the rabbit retina.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Cycloleucine; Dextromethorphan; Eye Proteins; gamma-Aminobutyric Acid; Glucose; Glutamates; Glutamic Acid; Intraocular Pressure; Ischemia; Kainic Acid; Kynurenic Acid; Memantine; N-Methylaspartate; Oxygen; Potassium Cyanide; Quinoxalines; Rabbits; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Retina; Retinal Vessels; Serotonin | 1994 |
Excitatory amino acid neurotransmission through both NMDA and non-NMDA receptors is involved in the anticonvulsant activity of felbamate in DBA/2 mice.
Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Binding, Competitive; Disease Models, Animal; Dose-Response Relationship, Drug; Felbamate; Female; Glycine; Injections, Intraperitoneal; Injections, Intraventricular; Kynurenic Acid; Male; Mice; Mice, Inbred DBA; N-Methylaspartate; Phenylcarbamates; Propylene Glycols; Quinoxalines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures; Serine; Stereoisomerism; Synaptic Transmission | 1994 |
A role for non-NMDA excitatory amino acid receptors in regulating the basal activity of rat globus pallidus neurons and their activation by the subthalamic nucleus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Bicuculline; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Extracellular Space; GABA-A Receptor Antagonists; Globus Pallidus; Kynurenic Acid; Male; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Thalamic Nuclei | 1994 |
Felbamate selectively blocks in vitro hippocampal kainate-induced irreversible electrical changes.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Electrophysiology; Felbamate; Hippocampus; Kainic Acid; Kynurenic Acid; Lamotrigine; Male; N-Methylaspartate; Pentobarbital; Phenylcarbamates; Propylene Glycols; Rats; Rats, Wistar; Triazines | 1995 |
A glutamate-activated chloride current in cone-driven ON bipolar cells of the white perch retina.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Chloride Channels; Chlorides; Cycloleucine; Dendrites; Glutamic Acid; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Kynurenic Acid; Membrane Potentials; N-Methylaspartate; Neurotoxins; Patch-Clamp Techniques; Perches; Picrotoxin; Quinoxalines; Quisqualic Acid; Receptors, Metabotropic Glutamate; Retina; Retinal Cone Photoreceptor Cells; Strychnine | 1995 |
Ethanol inhibition of recombinant heteromeric NMDA channels in the presence and absence of modulators.
Topics: Animals; Electrophysiology; Ethanol; Female; Ion Channels; Kynurenic Acid; Magnesium; N-Methylaspartate; Oxidation-Reduction; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Xenopus laevis; Zinc | 1995 |
Modulation by magnesium of the affinity of NMDA receptors for glycine in murine hippocampal neurones.
Topics: Animals; Calcium; Cells, Cultured; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Glycine Agents; Hippocampus; In Vitro Techniques; Ion Channel Gating; Kynurenic Acid; Magnesium; Mice; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1995 |
Molecular cloning and chromosomal localization of the key subunit of the human N-methyl-D-aspartate receptor.
Topics: 2-Amino-5-phosphonovalerate; Amino Acid Sequence; Animals; Base Sequence; Brain; Chromosome Mapping; Chromosomes, Human, Pair 9; Cricetinae; Dizocilpine Maleate; DNA; Humans; Hybrid Cells; Karyotyping; Kynurenic Acid; Macromolecular Substances; Magnesium; Molecular Sequence Data; N-Methylaspartate; Oocytes; Poly A; Receptors, N-Methyl-D-Aspartate; RNA; RNA, Messenger; Temporal Lobe; Xenopus; Zinc | 1993 |
Glutamate receptor agonists enhance the expression of BDNF mRNA in cultured cerebellar granule cells.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain-Derived Neurotrophic Factor; Cell Survival; Cells, Cultured; Cerebellum; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Ibotenic Acid; Kainic Acid; Kinetics; Kynurenic Acid; Molecular Weight; N-Methylaspartate; Nerve Growth Factors; Nerve Tissue Proteins; Quinoxalines; Quisqualic Acid; Rats; Rats, Sprague-Dawley; RNA; RNA, Messenger; Tetrodotoxin; Transcription, Genetic | 1993 |
Excitatory amino acid receptor mediation of sensory inputs to functionally identified dorsal horn neurons in cat spinal cord.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cats; Decerebrate State; Evoked Potentials; Glutamates; Glutamic Acid; Ibotenic Acid; Kainic Acid; Ketamine; Kynurenic Acid; N-Methylaspartate; Neurons; Quinoxalines; Quisqualic Acid; Receptors, Amino Acid; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Synapses | 1993 |
7-Chlorokynurenate prevents NMDA-induced and kainate-induced striatal lesions.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Diseases; Choline O-Acetyltransferase; Corpus Striatum; Dose-Response Relationship, Drug; Kainic Acid; Kynurenic Acid; Male; N-Methylaspartate; Quisqualic Acid; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Serine | 1993 |
Modulation of the glutamate-evoked release of arachidonic acid from mouse cortical neurons: involvement of a pH-sensitive membrane phospholipase A2.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amiloride; Ammonium Chloride; Animals; Arachidonic Acid; Calcium; Cell Membrane; Cell Survival; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Embryo, Mammalian; Female; Glutamic Acid; Harmaline; Hydrogen-Ion Concentration; Immunohistochemistry; Kainic Acid; Kinetics; Kynurenic Acid; Mice; N-Methylaspartate; Neurons; Phospholipases A; Phospholipases A2; Pregnancy; Time Factors; Tritium | 1995 |
Effects of excitatory amino acid antagonists on the phasic depolarizing events that occur in lumbar motoneurons during REM periods of active sleep.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cats; Electrooculography; Evoked Potentials; Excitatory Amino Acid Antagonists; Kynurenic Acid; Membrane Potentials; Motor Neurons; N-Methylaspartate; Sciatic Nerve; Sleep, REM; Spinal Cord; Synaptic Transmission | 1995 |
NMDA-mediated potentiation of the afferent synapse in the inner ear.
Topics: 2-Amino-5-phosphonovalerate; Ambystoma; Amplifiers, Electronic; Animals; Dizocilpine Maleate; Electrophysiology; Glycine; In Vitro Techniques; Kynurenic Acid; N-Methylaspartate; Neurons, Afferent; Physical Stimulation; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Synapses; Vestibule, Labyrinth | 1994 |
The pharmacology of SDZ EAA 494, a competitive NMDA antagonist.
Topics: Animals; Binding Sites; Cats; Corpus Striatum; Dose-Response Relationship, Drug; Electroshock; Kynurenic Acid; Mice; N-Methylaspartate; Nomifensine; Piperazines; Rats; Rats, Sprague-Dawley; Sodium; Spinal Cord | 1994 |
N-methyl-D-aspartic acid/glycine interactions on the control of 5-hydroxytryptamine release in raphe primary cultures.
Topics: Animals; Cells, Cultured; Embryo, Mammalian; Female; Gestational Age; Glutamates; Glutamic Acid; Glycine; Kinetics; Kynurenic Acid; N-Methylaspartate; Pregnancy; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Rhombencephalon; Serotonin; Strychnine; Valine | 1993 |
A comparison of the effects of ethanol and the competitive glycine antagonist 7-chlorokynurenic acid on N-methyl-D-aspartic acid-induced neurotransmitter release from rat hippocampal slices.
Topics: Animals; Dose-Response Relationship, Drug; Ethanol; Glycine; Hippocampus; In Vitro Techniques; Kynurenic Acid; Male; N-Methylaspartate; Neurotransmitter Agents; Norepinephrine; Rats; Rats, Sprague-Dawley; Serine | 1994 |
Evidence for NMDA receptor in the afferent synaptic transmission of the vestibular system.
Topics: 2-Amino-5-phosphonovalerate; Ambystoma; Animals; Glycine; Hair Cells, Auditory; In Vitro Techniques; Kynurenic Acid; Magnesium; N-Methylaspartate; Nerve Fibers; Neurons, Afferent; Receptors, N-Methyl-D-Aspartate; Semicircular Canals; Synapses; Synaptic Transmission; Vestibule, Labyrinth | 1994 |
Possible NMDA antagonist properties of drugs that affect high pressure neurological syndrome.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Alkaloids; Animals; Benzimidazoles; High Pressure Neurological Syndrome; Hippocampus; Indole Alkaloids; Kynurenic Acid; Mephenesin; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 1994 |
Preferential induction by stress of the N-methyl-D-aspartate recognition domain in discrete structures of rat brain.
Topics: 2-Amino-5-phosphonovalerate; Adrenal Cortex Hormones; Animals; Autoradiography; Behavior, Animal; Brain Chemistry; Cerebellum; Corpus Striatum; Cycloheximide; Dizocilpine Maleate; Dose-Response Relationship, Drug; Glycine; Hypothalamus; Kynurenic Acid; Male; N-Methylaspartate; Rats; Rats, Wistar; Stress, Physiological; Tritium | 1994 |
Synergism between the NMDA receptor antagonistic effects of ifenprodil and the glycine antagonist, 7-chlorokynurenate, in vivo.
Topics: Animals; Chromatography, High Pressure Liquid; Drug Synergism; Glycine; Injections; Kynurenic Acid; Male; N-Methylaspartate; Neostriatum; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine | 1994 |
Optical imaging of parallel fiber activation in the rat cerebellar cortex: spatial effects of excitatory amino acids.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Cerebellar Cortex; Electric Stimulation; Evoked Potentials; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Kainic Acid; Kynurenic Acid; Membrane Potentials; N-Methylaspartate; Nerve Fibers; Quisqualic Acid; Rats; Rats, Sprague-Dawley | 1993 |
Whole cell and single channel analysis of the kinetics of glycine-sensitive N-methyl-D-aspartate receptor desensitization.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Cells, Cultured; Female; Glycine; Kinetics; Kynurenic Acid; N-Methylaspartate; Neurons; Pregnancy; Rats; Receptors, N-Methyl-D-Aspartate; Superior Colliculi; Synapses | 1993 |
In vivo regulation of extracellular dopamine in the neostriatum: influence of impulse activity and local excitatory amino acids.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Biological Transport; Corpus Striatum; Dialysis; Dopamine; Exocytosis; Extracellular Space; Kainic Acid; Kynurenic Acid; Microchemistry; Models, Neurological; N-Methylaspartate; Nerve Endings; Neurotoxins; Prosencephalon; Quinoxalines; Rats; Substantia Nigra; Tetrodotoxin | 1993 |
Evidence for enhanced synaptic excitation in transplanted neostriatal neurons.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Electrophysiology; Fetal Tissue Transplantation; Glutamates; Glutamic Acid; Kynurenic Acid; Male; N-Methylaspartate; Neostriatum; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Substantia Nigra; Synapses; Synaptic Transmission | 1993 |
Diverse modulation by systemic lidocaine of iontophoretic NMDA and quisqualic acid induced excitations on rat dorsal horn neurons.
Topics: Animals; Drug Synergism; Glycine; Injections, Intravenous; Iontophoresis; Kynurenic Acid; Lidocaine; Male; N-Methylaspartate; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Strychnine | 1993 |
Indole-2-carboxylates, novel antagonists of the N-methyl-D-aspartate (NMDA)-associated glycine recognition sites: in vivo characterization.
Topics: Animals; Brain; Cerebellum; Cyclic GMP; Harmaline; Indoleacetic Acids; Kynurenic Acid; Ligands; Male; Mice; N-Methylaspartate; Pyrrolidinones; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1993 |
Pyramidal cells in piriform cortex receive a convergence of inputs from monoamine activated GABAergic interneurons.
Topics: Animals; Bicuculline; Cerebral Cortex; Dopamine; Evoked Potentials; gamma-Aminobutyric Acid; In Vitro Techniques; Interneurons; Kynurenic Acid; Male; Membrane Potentials; N-Methylaspartate; Norepinephrine; Pyramidal Tracts; Rats; Rats, Sprague-Dawley; Serotonin; Synapses | 1993 |
Cardiovascular responses to global cerebral ischemia: role of excitatory amino acids in the ventrolateral medullary pressor area.
Topics: Acetylcholine; Amino Acids; Animals; Antidiuretic Hormone Receptor Antagonists; Atropine; Blood Pressure; Brain Ischemia; Dose-Response Relationship, Drug; Glutamates; Heart Rate; Kainic Acid; Kynurenic Acid; Male; Medulla Oblongata; Muscimol; N-Methylaspartate; Quinoxalines; Quisqualic Acid; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, Vasopressin; Vasopressins | 1993 |
Effects of felbamate, kynurenic acid derivatives and NMDA antagonists on in vitro kainate-induced epileptiform activity.
Topics: Animals; Anticonvulsants; Excitatory Amino Acid Antagonists; Felbamate; Hippocampus; In Vitro Techniques; Kainic Acid; Kynurenic Acid; Male; N-Methylaspartate; Neuroprotective Agents; Phenylcarbamates; Propylene Glycols; Rats; Rats, Wistar | 1996 |
Human brain N-methyl-D-aspartate receptors regulating noradrenaline release are positively modulated by HIV-1 coat protein gp120.
Topics: Adult; Aged; Allosteric Site; Cerebral Cortex; Excitatory Amino Acid Antagonists; Female; Gene Products, env; Glycine; HIV Envelope Protein gp120; HIV-1; Humans; Kynurenic Acid; Male; Middle Aged; N-Methylaspartate; Norepinephrine; Peptide Fragments; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Synaptosomes | 1996 |
Modulation of spinal visceral nociceptive transmission by NMDA receptor activation in the rat.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Afferent Pathways; Animals; Colon; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Kynurenic Acid; Male; N-Methylaspartate; Neurons; Nociceptors; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Rectum; Serine; Skin; Spinal Cord; Synaptic Transmission | 1996 |
Use of subunit-specific antisense oligodeoxynucleotides to define developmental changes in the properties of N-methyl-D-aspartate receptors.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Animals, Newborn; Base Sequence; Cerebral Cortex; Excitatory Amino Acid Antagonists; Female; Gene Expression Regulation, Developmental; Glycine; Kynurenic Acid; Macromolecular Substances; Molecular Sequence Data; N-Methylaspartate; Oligonucleotides, Antisense; Oocytes; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Xenopus laevis | 1996 |
Effect of 1-aminocyclopropanecarboxylic acid on N-methyl-D-aspartate-stimulated [3H]-noradrenaline release in rat hippocampal synaptosomes.
Topics: Adrenergic alpha-Antagonists; Animals; Cyclopropanes; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; Kynurenic Acid; Male; N-Methylaspartate; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptosomes; Tritium | 1996 |
Excitoprotective effect of felbamate in cultured cortical neurons.
Topics: Animals; Anticonvulsants; Binding Sites; Calcium; Cell Death; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Felbamate; Glycine; Kainic Acid; Kynurenic Acid; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxins; Phenylcarbamates; Propylene Glycols; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Strychnine | 1995 |
Glycine and calcium-dependent effects of lead on N-methyl-D-aspartate receptor function in rat hippocampal neurons.
Topics: Animals; Binding Sites; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Glycine; Hippocampus; Kynurenic Acid; Lead; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1996 |
Differential action of NMDA antagonists on cholinergic neurotoxicity produced by N-methyl-D-aspartate and quinolinic acid.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Brain; Choline O-Acetyltransferase; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Antagonism; Excitatory Amino Acid Antagonists; Kynurenic Acid; Male; N-Methylaspartate; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1996 |
Differential effects of five glycine site antagonists on NMDA receptor desensitisation.
Topics: Animals; Benzothiadiazines; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glycine; Kynurenic Acid; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Quinolones; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1996 |
Tachycardia after glutamate injection in rat spinal cord is not blocked by kynurenate or mimicked by metabotropic agonists.
Topics: Aminobutyrates; Analysis of Variance; Animals; Blood Pressure; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Heart Rate; Injections, Spinal; Kainic Acid; Kynurenic Acid; N-Methylaspartate; Rats; Rats, Inbred WKY; Receptors, Metabotropic Glutamate; Spinal Cord; Tachycardia | 1996 |
Pharmacological characterization of inward current evoked by N-methyl-D-aspartate in dopamine neurons in the rat brain slice.
Topics: Animals; Dizocilpine Maleate; Excitatory Amino Acid Agonists; In Vitro Techniques; Kynurenic Acid; Magnesium; Male; Membrane Potentials; N-Methylaspartate; Phencyclidine; Piperidines; Rats; Rats, Sprague-Dawley; Sodium; Spermine; Substantia Nigra; Ventral Tegmental Area | 1996 |
Non-NMDA receptors transmit cardiopulmonary C fibre input in nucleus tractus solitarii in rats.
Topics: 2-Amino-5-phosphonovalerate; Afferent Pathways; Animals; Biguanides; Brain Mapping; Chemoreceptor Cells; Excitatory Amino Acid Antagonists; Heart; Heart Atria; Heart Conduction System; Heart Ventricles; Kynurenic Acid; Lung; Male; N-Methylaspartate; Nerve Fibers; Neurons; Pressoreceptors; Quinoxalines; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Serotonin Receptor Agonists; Solitary Nucleus; Vagus Nerve | 1996 |
Neurotoxicity associated with dual actions of homocysteine at the N-methyl-D-aspartate receptor.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adult; Animals; Cells, Cultured; Cerebral Cortex; Child; Dizocilpine Maleate; Embryo, Mammalian; Evoked Potentials; Glycine; Homocysteine; Humans; Kinetics; Kynurenic Acid; N-Methylaspartate; Neurons; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1997 |
Protection against quinolinic acid-mediated excitotoxicity in nigrostriatal dopaminergic neurons by endogenous kynurenic acid.
Topics: Alanine; Animals; Corpus Striatum; Dopamine; Drug Combinations; Injections, Intraventricular; Kynurenic Acid; Kynurenine; Male; N-Methylaspartate; Neurons; Neurotoxins; Niacin; Probenecid; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Substantia Nigra; Tyrosine 3-Monooxygenase | 1997 |
Estimation of the relative potency of two glycine antagonists on NMDA-induced depolarizations in BRSC and ARCS.
Topics: Animals; Cerebral Cortex; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Kainic Acid; Kynurenic Acid; N-Methylaspartate; Potassium Chloride; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Synaptic Transmission | 1997 |
NMDA receptor coagonist glycine site: evidence for a role in lateral hypothalamic stimulation of feeding.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Eating; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Hypothalamic Area, Lateral; Kainic Acid; Kynurenic Acid; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1997 |
Gp120 can revert antagonism at the glycine site of NMDA receptors mediating GABA release from cultured hippocampal neurons.
Topics: Animals; Binding Sites; Cells, Cultured; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fetus; gamma-Aminobutyric Acid; Glycine; Hippocampus; HIV Envelope Protein gp120; HIV-1; Kynurenic Acid; N-Methylaspartate; Neurons; Rats; Receptors, N-Methyl-D-Aspartate; Tritium | 1997 |
Neurotrophin modulation of NMDA receptors in cultured murine and isolated rat neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain-Derived Neurotrophic Factor; Calcium; Cells, Cultured; Corpus Striatum; Dynorphins; Embryo, Mammalian; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; Ion Channel Gating; Kynurenic Acid; Magnesium; Membrane Potentials; Mice; N-Methylaspartate; Nerve Growth Factors; Neurons; Neurotrophin 3; Protein Kinase Inhibitors; Pyramidal Cells; Rats; Rats, Wistar; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 1997 |
Interaction of GABA and excitatory amino acids in the basolateral amygdala: role in cardiovascular regulation.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amygdala; Animals; Arousal; Bicuculline; Blood Pressure; Dicarboxylic Acids; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Heart Rate; Hemodynamics; Kynurenic Acid; Male; N-Methylaspartate; Neurotransmitter Uptake Inhibitors; Picrotoxin; Piperazines; Pyrrolidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 1997 |
GV 150526A, 7-Cl-kynurenic acid and HA 966 antagonize the glycine enhancement of N-methyl-D-aspartate-induced [3H]noradrenaline and [3H]dopamine release.
Topics: Animals; Dopamine; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; Indoles; Kynurenic Acid; Male; N-Methylaspartate; Neostriatum; Norepinephrine; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Synaptosomes | 1997 |
Spontaneous openings of NMDA receptor channels in cultured rat hippocampal neurons.
Topics: Animals; Animals, Newborn; Cells, Cultured; Evoked Potentials; Hippocampus; Ion Channel Gating; Kynurenic Acid; Likelihood Functions; Magnesium; Membrane Potentials; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Rats; Receptors, N-Methyl-D-Aspartate | 1997 |
Impairment of brain kynurenic acid production by glutamate metabotropic receptor agonists.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebral Cortex; Cycloleucine; In Vitro Techniques; Kainic Acid; Kynurenic Acid; Male; N-Methylaspartate; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Sodium | 1997 |
Modulation of neuronal mitochondrial membrane potential by the NMDA receptor: role of arachidonic acid.
Topics: 2-Amino-5-phosphonovalerate; Anesthetics, Local; Animals; Arachidonic Acid; Biomarkers; Cells, Cultured; Cerebellum; Dibucaine; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Flow Cytometry; Fluorescent Dyes; Glycine; Intracellular Membranes; Kynurenic Acid; Membrane Potentials; Mitochondria; N-Methylaspartate; Piperidines; Quinacrine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Rhodamine 123; Rhodamines; Sulfonamides | 1997 |
2,3-Dihydro-6,7-dichloro-pyrido[2,3-b]pyrazine-8-oxide as selective glycine antagonist with in vivo activity.
Topics: Animals; Avoidance Learning; Binding Sites; Cyclic N-Oxides; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glycine; Kynurenic Acid; Mice; Motor Activity; N-Methylaspartate; Neuroprotective Agents; Pyrazines; Rats; Receptors, N-Methyl-D-Aspartate; Seizures; Stereotyped Behavior; Strychnine | 1997 |
Glycine increases arterial pressure and augments NMDA-induced pressor responses in the dorsomedial and ventrolateral medulla of cats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Blood Pressure; Cats; Dorsomedial Hypothalamic Nucleus; Drug Synergism; Excitatory Amino Acid Antagonists; Female; Glutamates; Glutamic Acid; Glycine; Kynurenic Acid; Male; Microinjections; N-Methylaspartate; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Ventromedial Hypothalamic Nucleus | 1997 |
Functional characterization of human N-methyl-D-aspartate subtype 1A/2D receptors.
Topics: Animals; Calcium; Cells, Cultured; DNA, Complementary; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fetus; Glutamic Acid; Glycine; Humans; Kidney; Kynurenic Acid; Membrane Potentials; Molecular Sequence Data; N-Methylaspartate; Oocytes; Patch-Clamp Techniques; Pipecolic Acids; Piperidines; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Sequence Homology, Amino Acid; Serine; Xenopus laevis | 1998 |
Glycine site antagonists and partial agonists inhibit N-methyl-D-aspartate receptor-mediated [3H]arachidonic acid release in cerebellar granule cells.
Topics: Amino Acids; Amino Acids, Cyclic; Animals; Arachidonic Acid; Cerebellum; Glutamic Acid; Kynurenic Acid; N-Methylaspartate; Rats; Rats, Wistar; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 1998 |
The ventral pallidum mediates disruption of prepulse inhibition of the acoustic startle response induced by dopamine agonists, but not by NMDA antagonists.
Topics: Acoustic Stimulation; Animals; Apomorphine; Dizocilpine Maleate; Dopamine Agonists; Excitatory Amino Acid Antagonists; Globus Pallidus; Injections; Kynurenic Acid; Male; N-Methylaspartate; Neural Inhibition; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Reflex, Startle | 1998 |
Dopaminergic control of kynurenate levels and N-methyl-D-aspartate toxicity in the developing rat striatum.
Topics: Aging; Animals; Animals, Newborn; Corpus Striatum; Dextroamphetamine; Dopamine; Dopamine Agents; Dopamine Antagonists; Excitatory Amino Acid Agonists; Haloperidol; Injections; Kynurenic Acid; Ligands; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2 | 1998 |
Chronic dosing with 1-aminocyclopropanecarboxylic acid, a glycine partial agonist, modulates NMDA inhibition of muscarinic-coupled PI hydrolysis in rat cortical slices.
Topics: 2-Amino-5-phosphonovalerate; Animals; Carbachol; Cerebral Cortex; Cycloleucine; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Hydrolysis; In Vitro Techniques; Inositol; Kynurenic Acid; Male; Muscarinic Agonists; N-Methylaspartate; Phosphatidylinositols; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1998 |
Assessing the roles of glutamatergic and cholinergic synaptic drive in the control of fictive swimming frequency in young Xenopus tadpoles.
Topics: Animals; Cholinergic Fibers; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Kynurenic Acid; Larva; N-Methylaspartate; Neural Inhibition; Quinoxalines; Receptors, Nicotinic; Swimming; Synapses; Xenopus | 1998 |
Mechanisms involved in the metabotropic glutamate receptor-enhancement of NMDA-mediated motoneurone responses in frog spinal cord.
Topics: Amino Acids, Dicarboxylic; Aminobutyrates; Animals; Benzoates; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Chlorpromazine; Cycloleucine; Dose-Response Relationship, Drug; Drug Synergism; Egtazic Acid; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; GTP-Binding Proteins; In Vitro Techniques; Kynurenic Acid; Magnesium; Membrane Potentials; Motor Neurons; N-Methylaspartate; Neuroprotective Agents; Pertussis Toxin; Rana pipiens; Receptors, Metabotropic Glutamate; Reflex; Resorcinols; Second Messenger Systems; Spinal Cord; Sulfonamides; Tetrodotoxin; Thapsigargin; Virulence Factors, Bordetella | 1999 |
Properties of NMDA receptors in rat spinal cord motoneurons.
Topics: 2-Amino-5-phosphonovalerate; Age Factors; Animals; Animals, Newborn; Electric Conductivity; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Glycine; Ion Channel Gating; Kainic Acid; Kynurenic Acid; Magnesium; Male; Motor Neurons; N-Methylaspartate; Organ Culture Techniques; Patch-Clamp Techniques; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1999 |
Cardiovascular response to group I metabotropic glutamate receptor activation in NTS.
Topics: Animals; Baroreflex; Benzoates; Blood Pressure; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Kainic Acid; Kynurenic Acid; Male; Methoxyhydroxyphenylglycol; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Sympathetic Nervous System | 1999 |
Aniracetam, 1-BCP and cyclothiazide differentially modulate the function of NMDA and AMPA receptors mediating enhancement of noradrenaline release in rat hippocampal slices.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antihypertensive Agents; Benzothiadiazines; Dioxoles; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Heterocyclic Compounds; Hippocampus; In Vitro Techniques; Kynurenic Acid; Male; N-Methylaspartate; Nootropic Agents; Norepinephrine; Piperidines; Pyrrolidinones; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Tritium | 1999 |
Effects of puerarin against glutamate excitotoxicity on cultured mouse cerebral cortical neurons.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Isoflavones; Kainic Acid; Kynurenic Acid; L-Lactate Dehydrogenase; Mice; N-Methylaspartate; Neurons; Neuroprotective Agents; Quinoxalines; Sodium Glutamate | 1998 |
Activity of putative cognition enhancers in kynurenate test performed with human neocortex slices.
Topics: Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Humans; In Vitro Techniques; Kynurenic Acid; N-Methylaspartate; Neocortex; Nootropic Agents; Norepinephrine; Receptors, N-Methyl-D-Aspartate | 1999 |
Regulation by glycine, Mg2+ and polyamines of the N-methyl-D-aspartate-induced locomotion in the neonatal rat spinal cord in vitro.
Topics: Animals; Biguanides; Excitatory Amino Acid Antagonists; Glycine; In Vitro Techniques; Kynurenic Acid; Magnesium; Motor Activity; Motor Neurons; N-Methylaspartate; Polyamines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermine; Spinal Cord; Synapses | 1999 |
Chemical stimulation of the ventral hippocampus elevates nucleus accumbens dopamine by activating dopaminergic neurons of the ventral tegmental area.
Topics: Animals; Dopamine; Hippocampus; Kynurenic Acid; Male; Microdialysis; Microinjections; N-Methylaspartate; Neurons; Nucleus Accumbens; Perfusion; Rats; Rats, Long-Evans; Tetrodotoxin; Ventral Tegmental Area | 2000 |
Glycine induced calcium concentration changes in vestibular type I sensory cells.
Topics: Animals; Calcium; Chelating Agents; Chlorides; Egtazic Acid; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamates; Glycine; Guinea Pigs; Hair Cells, Vestibular; Kynurenic Acid; Models, Neurological; N-Methylaspartate; Strychnine | 2000 |
Modulation and function of kynurenic acid in the immature rat brain.
Topics: 2-Amino-5-phosphonovalerate; Aging; Alanine; Animals; Brain; Dextroamphetamine; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glucose; Kynurenic Acid; Kynurenine 3-Monooxygenase; Male; Microdialysis; Mixed Function Oxygenases; N-Methylaspartate; Neurons; Pyruvates; Rats; Rats, Sprague-Dawley | 1999 |
Systemically administered D-glucose conjugates of 7-chlorokynurenic acid are centrally available and exert anticonvulsant activity in rodents.
Topics: Animals; Anticonvulsants; Astrocytes; Biotransformation; Blood-Brain Barrier; Cells, Cultured; Cerebral Cortex; Culture Media, Conditioned; Epilepsies, Partial; Epilepsy, Tonic-Clonic; Excitatory Amino Acid Antagonists; Galactose; Glucose; Injections, Intraperitoneal; Kynurenic Acid; Male; Mice; Microdialysis; Molecular Structure; N-Methylaspartate; Neurons; Neuroprotective Agents; Prodrugs; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship | 2000 |
Neuroprotective potency of kynurenic acid against excitotoxicity.
Topics: Animals; Cerebral Cortex; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Extracellular Space; Kynurenic Acid; Male; Microdialysis; N-Methylaspartate; Neuroprotective Agents; Quinolinic Acid; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 2000 |
Enhancement of NMDA-induced current by the putative NR2B selective antagonist ifenprodil.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Kynurenic Acid; Male; Membrane Potentials; N-Methylaspartate; Organ Culture Techniques; Piperidines; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermine | 2000 |
Modification of the Xenopus electroretinogram by actions of glycine in the proximal retina.
Topics: Aminobutyrates; Animals; Dose-Response Relationship, Drug; Electroretinography; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Glycine Agents; In Vitro Techniques; Kynurenic Acid; N-Methylaspartate; Photic Stimulation; Pipecolic Acids; Retina; Strychnine; Xenopus laevis | 2000 |
Synthesis, pharmacokinetics and anticonvulsant activity of 7-chlorokynurenic acid prodrugs.
Topics: Animals; Blood-Brain Barrier; Cells, Cultured; Esters; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Kynurenic Acid; Mice; N-Methylaspartate; Neurons; Prodrugs; Seizures | 2000 |
Kynurenine 3-hydroxylase inhibition in rats: effects on extracellular kynurenic acid concentration and N-methyl-D-aspartate-induced depolarisation in the striatum.
Topics: Administration, Oral; Animals; Cerebral Cortex; Corpus Striatum; Electroencephalography; Enzyme Inhibitors; Extracellular Space; Injections, Intraperitoneal; Kynurenic Acid; Kynurenine 3-Monooxygenase; Male; Membrane Potentials; Microdialysis; Mixed Function Oxygenases; N-Methylaspartate; Neuroprotective Agents; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Sulfonamides; Thiazoles | 2000 |
Anoxic depolarization mediates acute damage independent of glutamate in neocortical brain slices.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Brain Ischemia; Cortical Spreading Depression; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Hypoxia; Kynurenic Acid; Male; N-Methylaspartate; Neocortex; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Glutamate | 2001 |
Relapse to cocaine-seeking after hippocampal theta burst stimulation.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Dopamine; Electric Stimulation; Electrodes; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Extinction, Psychological; Glutamic Acid; Hippocampus; Injections, Intravenous; Kynurenic Acid; Medial Forebrain Bundle; Memory; N-Methylaspartate; Rats; Rats, Long-Evans; Recurrence; Reward; Self Administration; Synaptic Transmission; Theta Rhythm; Ventral Tegmental Area | 2001 |
Glutamatergic afferents from the hippocampus to the nucleus accumbens regulate activity of ventral tegmental area dopamine neurons.
Topics: Action Potentials; Afferent Pathways; Animals; Cell Count; Dopamine; Dose-Response Relationship, Drug; Glutamic Acid; Hippocampus; Kynurenic Acid; Male; N-Methylaspartate; Neurons; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Tetrodotoxin; Ventral Tegmental Area | 2001 |
The brain metabolite kynurenic acid inhibits alpha7 nicotinic receptor activity and increases non-alpha7 nicotinic receptor expression: physiopathological implications.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Binding, Competitive; Brain; Cells, Cultured; Choline; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Administration Schedule; Electrophysiology; Glycine; Hippocampus; In Vitro Techniques; Kynurenic Acid; Male; N-Methylaspartate; Neurons; Nicotine; Nicotinic Agonists; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptor Cross-Talk; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic | 2001 |
Synergistic versus antagonistic actions of glutamate and glutathione: the role of excitotoxicity and oxidative stress in neuronal disease.
Topics: Animals; Behavior, Animal; Cerebral Cortex; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Flour; Glutamic Acid; Glutathione; Kynurenic Acid; L-Lactate Dehydrogenase; Male; Methionine Sulfoximine; Mice; Mice, Inbred Strains; N-Methylaspartate; Nervous System Diseases; Oxidative Stress; Plants, Toxic; Rats; Rats, Sprague-Dawley; Sitosterols | 2002 |
Contributions from rostral medullary nuclei to coordination of swallowing and breathing in awake goats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Consciousness; Deglutition; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Goats; Kynurenic Acid; Medulla Oblongata; Microinjections; N-Methylaspartate; Quinoxalines; Receptors, Glutamate; Respiratory Mechanics | 2002 |
A glycine receptor antagonist, strychnine, blocked NMDA receptor activation in the neonatal mouse neocortex.
Topics: Animals; Animals, Newborn; Calcium; Calcium Signaling; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; GABA Antagonists; GABA-A Receptor Antagonists; Glycine Agents; Kynurenic Acid; Magnesium; Membrane Potentials; Mice; Mice, Knockout; N-Methylaspartate; Neocortex; Neurons; Picrotoxin; Receptors, GABA-A; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Strychnine; Synaptic Transmission | 2002 |
Stimulation of cortical acetylcholine release following blockade of ionotropic glutamate receptors in nucleus accumbens.
Topics: Acetylcholine; Animals; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Kynurenic Acid; Male; Microdialysis; N-Methylaspartate; Nucleus Accumbens; Prefrontal Cortex; Quinoxalines; Rats | 2002 |
Differential alterations in the expression of NMDA receptor subunits following chronic ethanol treatment in primary cultures of rat cortical and hippocampal neurones.
Topics: Animals; Animals, Newborn; Cells, Cultured; Cerebral Cortex; Culture Media, Serum-Free; Dizocilpine Maleate; Ethanol; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Hippocampus; Kynurenic Acid; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Piperidines; Protein Subunits; Rats; Receptors, N-Methyl-D-Aspartate; RNA Splicing | 2003 |
Evidence against the presence of NMDA receptors at a central glutamatergic synapse in leeches.
Topics: 2-Amino-5-phosphonovalerate; Animals; Association Learning; Central Nervous System; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Kynurenic Acid; Leeches; Motor Neurons; N-Methylaspartate; Neurons, Afferent; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Reflex; Synapses; Synaptic Transmission | 2002 |
Role of paraventricular nucleus in regulation of sympathetic nerve frequency components.
Topics: Animals; Bicuculline; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Antagonists; Kidney; Kynurenic Acid; Male; Microinjections; N-Methylaspartate; omega-N-Methylarginine; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Rest; Spleen; Stress, Physiological; Sympathetic Nervous System | 2003 |
Alterations of kynurenic acid content in the retina in response to retinal ganglion cell damage.
Topics: Animals; Cell Death; Chromatography, High Pressure Liquid; Kynurenic Acid; Male; N-Methylaspartate; Rats; Rats, Inbred BN; Retina; Retinal Degeneration; Retinal Ganglion Cells | 2003 |
Involvement of N-methyl-D-aspartate receptors in post-hypoxic depression of the dorsomedial medulla in cats.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Blood Gas Analysis; Blood Pressure; Cats; Depression, Chemical; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Heart Rate; Hypoxia; Kynurenic Acid; Male; Medulla Oblongata; Microinjections; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Spinal Nerves | 2003 |
Potentiation of N-methyl-D-aspartate-induced currents by the nootropic drug nefiracetam in rat cortical neurons.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Electrophysiology; Female; Glycine; Kynurenic Acid; N-Methylaspartate; Neurons; Nootropic Agents; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate | 2003 |
Behavioral effects of NMDA receptor agonists and antagonists in combination with nitric oxide-related compounds.
Topics: 2-Amino-5-phosphonovalerate; Animals; Arginine; Conditioning, Operant; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Gallic Acid; Guanidines; Indazoles; Injections, Intraperitoneal; Kynurenic Acid; Molsidomine; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitroprusside; Phencyclidine; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2003 |
Evidence for a glutamatergic modulation of the cholinergic function in the human enteric nervous system via NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Aged; Colon, Ascending; Colon, Sigmoid; Enteric Nervous System; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Humans; Immunohistochemistry; In Vitro Techniques; Kynurenic Acid; Male; Muscle, Smooth; N-Methylaspartate; Neurons; Receptors, N-Methyl-D-Aspartate | 2003 |
AMPA-receptor activation is involved in the antiamnesic effect of DM 232 (unifiram) and DM 235 (sunifiram).
Topics: Amnesia; Animals; Avoidance Learning; Cognition; Dose-Response Relationship, Drug; Electrophysiology; Hippocampus; Kynurenic Acid; Male; Mice; N-Methylaspartate; Nootropic Agents; Piperazines; Pyrroles; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA | 2003 |
Putative NMDA receptors in Hydra: a biochemical and functional study.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Binding Sites; Cell Membrane; Concanavalin A; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Feeding Behavior; Glutamic Acid; Glutathione; Glycine; Hydra; Kynurenic Acid; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Serine; Strychnine | 2004 |
Structural consequences of D481N/K483Q mutation at glycine binding site of NMDA ionotropic glutamate receptors: a molecular dynamics study.
Topics: Amino Acid Sequence; Binding Sites; Computer Simulation; Crystallography, X-Ray; Glycine; Hydrogen Bonding; Kynurenic Acid; Models, Molecular; Molecular Sequence Data; N-Methylaspartate; Point Mutation; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Receptors, N-Methyl-D-Aspartate; Sequence Homology, Amino Acid; Water | 2005 |
Antiallodynic effects of NMDA glycine(B) antagonists in neuropathic pain: possible peripheral mechanisms.
Topics: Action Potentials; Animals; Constriction, Pathologic; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Kynurenic Acid; Ligation; Male; N-Methylaspartate; Neuralgia; Neurons, Afferent; Pain Measurement; Quinolones; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Nerves; Time Factors | 2005 |
Kynurenic acid attenuates NMDA-induced pial arteriolar dilation in newborn pigs.
Topics: Analysis of Variance; Animals; Animals, Newborn; Brain Ischemia; Cerebral Arteries; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Hypercapnia; Kynurenic Acid; Male; N-Methylaspartate; Quinolinic Acid; Swine; Time Factors; Vasodilation | 2006 |
Kynurenic acid synthesis in bovine retinal slices--effect of glutamate agonists.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Cattle; Excitatory Amino Acid Agonists; Glutamic Acid; Kynurenic Acid; N-Methylaspartate; Organ Culture Techniques; Retina | 2006 |
Is endogenous D-serine in the rostral anterior cingulate cortex necessary for pain-related negative affect?
Topics: Animals; Anxiety; D-Amino-Acid Oxidase; Excitatory Amino Acid Antagonists; Fear; Glycine; Gyrus Cinguli; Kynurenic Acid; Male; Membrane Potentials; N-Methylaspartate; Organ Culture Techniques; Pain; Pain Measurement; Pain Threshold; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Serine; Stress, Psychological; Synaptic Transmission | 2006 |
Taurine potentiates presynaptic NMDA receptors in hippocampal Schaffer collateral axons.
Topics: Animals; Axons; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Glycine; Hippocampus; Kynurenic Acid; Male; N-Methylaspartate; Organ Culture Techniques; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Serine; Synaptic Transmission; Taurine | 2006 |
Contribution of endogenous glycine site NMDA agonists to excitotoxic retinal damage in vivo.
Topics: Amidohydrolases; Animals; Cell Death; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Kynurenic Acid; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Retinal Diseases; Retinal Ganglion Cells; Serine | 2006 |
Dopamine receptor activation reveals a novel, kynurenate-sensitive component of striatal N-methyl-D-aspartate neurotoxicity.
Topics: Animals; Astrocytes; Cell Death; Corpus Striatum; Dopamine; Dopamine Agonists; Excitatory Amino Acid Agonists; Female; Glutamic Acid; Humans; Kynurenic Acid; N-Methylaspartate; Nerve Degeneration; Neurotoxins; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, N-Methyl-D-Aspartate | 2007 |
Kynurenic acid inhibits intestinal hypermotility and xanthine oxidase activity during experimental colon obstruction in dogs.
Topics: Animals; Colonic Pseudo-Obstruction; Disease Models, Animal; Dogs; Gastrointestinal Motility; Hemodynamics; Kynurenic Acid; N-Methylaspartate; Nitrates; Nitrites; Peroxidase; Xanthine Oxidase | 2008 |
N-methyl-D-aspartate receptors and amnesia in mice with depression-like state.
Topics: Amnesia; Analysis of Variance; Animals; Avoidance Learning; Behavior, Animal; Cycloserine; Depression; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Kynurenic Acid; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Receptors, Amino Acid | 2007 |
Recent advances in the treatment of amyotrophic lateral sclerosis. Emphasis on kynurenine pathway inhibitors.
Topics: Adult; Amyotrophic Lateral Sclerosis; Animals; Brain; D-Aspartic Acid; Functional Laterality; Humans; Japan; Kynurenic Acid; Kynurenine; Motor Neurons; N-Methylaspartate; Quinolinic Acid; Riluzole; Signal Transduction; Tryptophan | 2009 |
Activation of N-methyl-D-aspartate (NMDA) receptors in the dorsal vagal complex lowers glucose production.
Topics: 2-Amino-5-phosphonovalerate; Animals; Gene Knockdown Techniques; Glucose; Glycine; Humans; Kynurenic Acid; Liver; Male; N-Methylaspartate; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Vagotomy; Vagus Nerve | 2010 |
Neuroprotection by acetoacetate and β-hydroxybutyrate against NMDA-induced RGC damage in rat--possible involvement of kynurenic acid.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Cell Count; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Female; Injections, Intraperitoneal; Kynurenic Acid; N-Methylaspartate; Neuroprotective Agents; Rats; Rats, Inbred BN; Retinal Ganglion Cells | 2010 |
Protective activity of α-lactoalbumin (ALAC), a whey protein rich in tryptophan, in rodent models of epileptogenesis.
Topics: Animals; Convulsants; Epilepsy; Epilepsy, Absence; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; Kynurenic Acid; Lactalbumin; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Milk Proteins; N-Methylaspartate; Pentylenetetrazole; Pilocarpine; Rats; Tryptophan; Whey Proteins | 2012 |
Temporal alteration of spreading depression by the glycine transporter type-1 inhibitors NFPS and Org-24461 in chicken retina.
Topics: Animals; Chickens; CHO Cells; Cortical Spreading Depression; Cricetinae; Cricetulus; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine Plasma Membrane Transport Proteins; Humans; Kynurenic Acid; N-Methylaspartate; Retina; Sarcosine | 2013 |
Excitatory amino acid receptors mediate asymmetry and lateralization in the descending cardiovascular pathways from the dorsomedial hypothalamus.
Topics: Animals; Dorsomedial Hypothalamic Nucleus; Excitatory Amino Acid Antagonists; Functional Laterality; Heart Rate; Histological Techniques; Kynurenic Acid; N-Methylaspartate; Neural Pathways; Periaqueductal Gray; Rats; Receptors, Glutamate; Tachycardia | 2014 |
A Metabotropic-Like Flux-Independent NMDA Receptor Regulates Ca2+ Exit from Endoplasmic Reticulum and Mitochondrial Membrane Potential in Cultured Astrocytes.
Topics: 2-Amino-5-phosphonovalerate; Aniline Compounds; Animals; Astrocytes; Benzimidazoles; Calcium; Calcium Channel Blockers; Carbocyanines; Cells, Cultured; Dizocilpine Maleate; Endoplasmic Reticulum; Inositol 1,4,5-Trisphosphate Receptors; Ions; Kynurenic Acid; Membrane Potential, Mitochondrial; N-Methylaspartate; Protein Subunits; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; RNA, Small Interfering; Xanthenes | 2015 |
Oral administration of a specific kynurenic acid synthesis (KAT II) inhibitor attenuates evoked glutamate release in rat prefrontal cortex.
Topics: Administration, Oral; Analysis of Variance; Animals; Dose-Response Relationship, Drug; Drug Administration Routes; Electrodes; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glutamic Acid; Heterocyclic Compounds, 3-Ring; Kynurenic Acid; Kynurenine; Male; Microdialysis; N-Methylaspartate; Neural Pathways; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Wistar; Thiazolidinediones; Transaminases | 2017 |
Kynurenic Acid Prevents Cytoskeletal Disorganization Induced by Quinolinic Acid in Mixed Cultures of Rat Striatum.
Topics: Animals; Antioxidants; Astrocytes; Cell Communication; Cells, Cultured; Corpus Striatum; Cytoskeleton; Dizocilpine Maleate; Gap Junctions; Kynurenic Acid; Microglia; Models, Biological; N-Methylaspartate; Neurons; Oxidative Stress; Quinolinic Acid; Rats, Wistar; Signal Transduction; Tumor Necrosis Factor-alpha | 2018 |
Kynurenic Acid and Its Analogue SZR-72 Ameliorate the Severity of Experimental Acute Necrotizing Pancreatitis.
Topics: Animals; Interleukin-1beta; Kynurenic Acid; Male; Microcirculation; N-Methylaspartate; Pancreatitis, Acute Necrotizing; Patient Acuity; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2021 |