kynurenic acid has been researched along with glycine in 266 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (7.89) | 18.7374 |
| 1990's | 166 (62.41) | 18.2507 |
| 2000's | 56 (21.05) | 29.6817 |
| 2010's | 22 (8.27) | 24.3611 |
| 2020's | 1 (0.38) | 2.80 |
| Authors | Studies |
|---|---|
| Iversen, LL; Leeson, PD | 1 |
| Bostock, E; Sorrels, TL | 1 |
| Epstein, FH; Heyman, S; Rosen, S; Spokes, K | 1 |
| Bussey, TJ; Phillips, AG; Wood, ER | 2 |
| Lipton, SA; Zhang, D | 1 |
| Peeters, BW; Vanderheyden, PM | 1 |
| Alesiani, M; Ciuffi, M; Facci, L; Fadda, E; Galli, A; Lombardi, G; Mori, F; Moroni, F; Natalini, B; Skaper, SD | 1 |
| Blanchard, JC; Canton, T; Doble, A; Jimonet, P; Miquet, JM | 1 |
| Aceves, J; Góngora-Alfaro, JL; Hernández, S; Martínez-Fong, D; Rosales, MG | 1 |
| Carling, RW; Donald, AE; Foster, AC; Grimwood, S; Kemp, JA; Leeson, PD; Marshall, GR; Priestley, T; Smith, JD | 1 |
| Lodge, D; Millar, JD; Pralong, E | 1 |
| Fink, K; Göthert, M; Schultheiss, R | 1 |
| Abe, K; Himi, T; Saito, H; Watanabe, Y | 1 |
| Barun, S; Dalkara, T; Erdemli, G; Onur, R | 1 |
| Lazarewicz, JW; Puka, M; Salińska, E | 1 |
| Baker, R; Carling, RW; Foster, AC; Grimwood, S; Kemp, JA; Leeson, PD; Marshall, GR; Moseley, AM | 1 |
| Baker, R; Carling, RW; Chan, T; Foster, AC; Grimwood, S; Leeson, PD; Moore, KW; Moseley, AM; Smith, JD; Stevenson, G | 1 |
| Bradford, HF; Croucher, MJ | 1 |
| Peterson, SL | 2 |
| Connick, JH; Stone, TW | 1 |
| Abe, K; Mizutani, A; Saito, H | 1 |
| Kemp, JA; Priestley, T | 1 |
| Canton, H; Colpaert, F; Lehmann, J | 1 |
| Bekkers, JM; Stevens, CF | 1 |
| Sircar, R; Zukin, SR | 1 |
| Beart, PM; Conway, EL; Manallack, DT; Mercer, LD; O'Shea, RD | 1 |
| Abrahams, TP; Gillis, RA; Hornby, PJ; Taveira DaSilva, AM; Walton, DP | 1 |
| Glantz, RM; Pfeiffer-Linn, C | 1 |
| Frusciante, MJ; Javitt, DC; Nussenzveig, IZ; Sircar, R; Wong, ML; Zukin, SR | 1 |
| Agarwal, SK; Calaresu, FR; Chitravanshi, VC | 1 |
| Kloog, Y; Lamdani-Itkin, H; Sokolovsky, M | 1 |
| Ascher, P; Henderson, G; Johnson, JW | 1 |
| Benveniste, M; Mayer, ML | 1 |
| Haesslein, JL; Hunt, PF; Jouanen, A; Massardier, D; Tremblet, AM | 1 |
| Alesiani, M; Carlà, V; Cherici, G; Galli, A; Mori, F; Moroni, F; Pecorari, R; Pellicciari, R | 1 |
| Colling, JM; Robertson, SC; Talman, WT | 1 |
| Baker, R; Carling, RW; Curtis, NR; Donald, AE; Foster, AC; Kemp, JA; Leeson, PD; Marshall, GR; Moore, KW; Williams, BJ | 1 |
| Aydar, E; Dickenson, AH | 1 |
| Grillner, P; Grillner, S; Hill, R | 1 |
| Baron, BM; Harrison, BL; Hurt, SD; Palfreyman, MG; Siegel, BW; Slone, AL | 1 |
| Baron, BM; Hurt, SD | 1 |
| Craig, CG; White, TD | 1 |
| Paschetto, KA; Pullan, LM; Verticelli, AM | 1 |
| Compton, RP; Cordi, AA; Hood, WF; Monahan, JB; Williams, RM | 1 |
| Insel, TR; Skolnick, P; Trullas, R; Winslow, JT | 1 |
| Bakshi, R; Faden, AI | 1 |
| Benveniste, M; Mayer, ML; Mienville, JM; Sernagor, E | 1 |
| Okamoto, K; Sakai, Y; Sekiguchi, M | 1 |
| Baimbridge, KG; Kessler, M; Lynch, G; Oliver, MW; Shacklock, JA | 1 |
| Ashbeck, GA; Tauck, DL | 1 |
| Kendall, DA; Robinson, JP | 1 |
| Dingledine, R; McNamara, D | 1 |
| Dow, KE; Riopelle, RJ | 1 |
| Keith, R; Patel, J; Salama, A; Thompson, C; Zinkand, WC | 1 |
| Baron, BM; Cousino, DM; Harrison, BL; McDonald, IA | 1 |
| Aizenman, E; Reynolds, IJ; Rush, EA | 1 |
| Horne, AL; Kemp, JA; McKernan, RM; Priestley, T | 1 |
| Calligaro, DO; Dingledine, R; McNamara, D; McQuaid, LA; O'Malley, PJ; Smith, EC | 1 |
| Dingledine, R; Kleckner, NW; McBain, CJ | 1 |
| Donald, AE; Foster, AC; Kemp, JA; Priestley, T; Tridgett, R; Willis, CL | 1 |
| Colpaert, FC; Koek, W | 1 |
| Chizhmakov, IV; Kiskin, NI; Krishtal, OA | 1 |
| Bashir, ZI; Collingridge, GL; Tam, B | 1 |
| Franchi-Micheli, S; Galli, A; Luzzi, S; Mori, F; Zilletti, L | 1 |
| Kessler, M; Larson, J; Lynch, G; Oliver, MW; Schottler, F | 1 |
| Benveniste, M; Mayer, ML; Vyklický, L | 1 |
| Baron, BM; Harrison, BL; McDonald, IA; Miller, FP; Palfreyman, MG; Salituro, FG; Schmidt, CJ; Sorensen, SM; White, HS | 1 |
| Darnall, RA; Guyenet, PG; Riley, TA | 1 |
| Larson, J; Lynch, G; Oliver, MW | 1 |
| Gale, K; Graham, J; Wardas, J | 1 |
| Clifford, DB; Izumi, Y; Zorumski, CF | 1 |
| Alesiani, M; Cherici, G; Galli, A; Moroni, F; Pellegrini-Giampietro, DE | 1 |
| Ceserani, R; Gaviraghi, G; Maraia, G; Reggiani, A | 1 |
| McGeer, EG; McGeer, PL; Zhu, SG | 1 |
| Baudry, M; Kessler, M; Lynch, G; Terramani, T | 1 |
| Flynn, DM; Thomson, AM; Walker, VE | 1 |
| Chenard, B; Prochniak, M; Shalaby, I | 1 |
| Dingledine, R; Kleckner, NW | 1 |
| Cler, JA; Pullan, LM | 1 |
| Frusciante, MJ; Javitt, DC; Sircar, R; Zukin, SR | 1 |
| Johnson, KM; Sacaan, AI | 1 |
| Harris, KM; Miller, RJ | 1 |
| Alesiani, M; Cherici, G; Galli, A; Mori, F; Moroni, F; Pellegrini-Giampietro, DE | 1 |
| Costa, E; Danysz, W; Fadda, E; Wroblewski, JT | 1 |
| Desban, M; Gauchy, C; Glowinski, J; Kemel, ML; Krebs, MO | 1 |
| Johnston, MV; McDonald, JW; Silverstein, FS; Uckele, JE | 1 |
| Foster, AC; Iversen, LL; Kemp, JA; Leeson, PD; Priestley, T; Tridgett, R; Woodruff, GN | 1 |
| Birch, PJ; Grossman, CJ; Hayes, AG | 1 |
| Mayer, ML; Vyklický, L; Westbrook, GL | 1 |
| Kiseleva, IP; Lapin, IP; Prakhie, IB | 1 |
| Deschenes, NL; Ransom, RW | 1 |
| Leklem, JE | 1 |
| Bergamaschi, C; Campos, RR; Lopes, OU; Schor, N | 1 |
| Anegawa, NJ; Lynch, DR; Pritchett, DB; Verdoorn, T | 1 |
| Aguglia, U; Bertorelli, R; De Sarro, A; De Sarro, G; Ongini, E | 1 |
| Baudry, M; Marvizón, JC | 2 |
| MacDonald, JF; Wang, LY | 1 |
| Guastella, J; Huettner, JE; Keana, JF; Weber, E; Woodward, RM | 1 |
| Pattarini, R; Pittaluga, A; Raiteri, M | 1 |
| Lukasiewicz, PD; Roeder, RC | 1 |
| Barth, A; Malouf, AT; Newell, DW | 1 |
| McNamara, M; Nowak, G; Paul, IA; Redmond, A | 1 |
| Flores, A; Soto, E; Vega, R | 1 |
| Carobrez, AP; Graeff, FG; Guimarães, FS; Matheus, MG; Nogueira, RL | 1 |
| Nolan, JP; Panizzon, KL; Wallis, RA | 1 |
| Cozzi, A; Moroni, F; Pellegrini-Giampietro, DE | 1 |
| Becquet, D; Deprez, P; Fache, MP; Faudon, M; Giraud, P; Héry, F; Héry, M | 1 |
| Layer, RT; Nowak, G; Paul, IA; Skolnick, P | 1 |
| Woodward, JJ | 1 |
| Eróstegui, C; Flores, A; Soto, E; Vega, R | 1 |
| Oblin, A; Schoemaker, H | 1 |
| Frusciante, MJ; Javitt, DC; Zukin, SR | 1 |
| Han, D; Ogita, K; Yoneda, Y | 1 |
| Ary, T; Faull, RL; McCabe, RT; Narang, N; Sofia, RD; Wamsley, JK | 1 |
| Löscher, W; Rundfeldt, C; Wlaź, P | 1 |
| Ary, T; Faull, RL; Gan, XD; McCabe, RT; Narang, N; Sofia, RD; Wamsley, JK | 1 |
| Ohno, M; Watanabe, S; Yamamoto, T | 1 |
| Carter, C; Fage, D; Voltz, C | 1 |
| Penney, JB; Sakurai, SY; Young, AB | 1 |
| Boje, KM; Skolnick, P; Wong, G | 1 |
| Bowery, NG; Gaviraghi, G; Marien, MR; Ratti, E; Tacconi, S | 1 |
| Lux, HD; Parsons, CG; Zong, X | 1 |
| Layer, RT; Nowak, G; Paul, IA; Skolnick, P; Trullas, R | 1 |
| Abe, K; Saito, H | 1 |
| Corbett, R; Dunn, RW | 1 |
| Giberti, A; Mugnaini, M; Ratti, E; van Amsterdam, FT | 1 |
| Layer, RT; Nowak, G; Paul, IA; Popik, P; Skolnick, P | 1 |
| Challiss, RA; Nahorski, SR; Simpson, PB | 1 |
| Biella, G; Lacerenza, M; Marchettini, P; Sotgiu, ML | 1 |
| Krassioukov, AV; Weaver, LC | 1 |
| Nowak, G; Paul, IA; Popik, P; Skolnick, P; Young, A | 1 |
| Ogita, K; Suzuki, T; Yoneda, Y | 1 |
| Cappendijk, SL; de Vries, R; Dzoljic, MR | 1 |
| Han, D; Ogita, K; Suzuki, T; Yoneda, Y | 1 |
| Layer, RT; Olds, T; Popik, P; Skolnick, P | 1 |
| Betz, H; Hirai, H; Kirsch, J; Kuhse, J; Laube, B | 1 |
| Pattarini, R; Pittaluga, A; Raiteri, M; Severi, P | 1 |
| Cai, SX; Egbuwoku, ZO; Hawkinson, JE; Huang, JC; Keana, JF; Lü, Y; Weber, E; Whittemore, ER; Woodward, RM; Zhou, ZL | 1 |
| Kretschmer, BD; Schmidt, WJ | 1 |
| Gribkoff, VK; Molinoff, PB; Zhong, J | 1 |
| Badia, A; Clos, MV; Garcia Sanz, A; Trullas, R | 1 |
| Gunasekar, PG; Kanthasamy, AG; Matsumoto, RR; Trunong, DD | 1 |
| Franklin, PH; Ishmael, JE; Leid, M; Murray, TF | 1 |
| Baron, BM; Gross, RS; Harrison, BL; Hawes, C; Siegel, BW; Towers, P | 1 |
| Albuquerque, EX; Aracava, Y; Marchioro, M; Swanson, KL | 1 |
| Erdõ, SL; Molnár, P | 1 |
| Gondo, M; Goodman, JC; Robertson, CS; Simpson, RK | 1 |
| Iizuka, M; Kudo, N; Nishimaru, H; Ozaki, S | 1 |
| Attwell, D; Sarantis, M; Takahashi, M | 1 |
| Cai, SX; Espitia, SA; Hawkinson, JE; Ilyin, V; Keana, JF; Kher, SM; Tran, M; Weber, E; Woodward, RM; Zhou, ZL | 1 |
| Han, Y; Slaughter, MM; Zhang, J | 1 |
| Arnelle, DR; Choi, YB; D'Emilia, DM; Kim, WK; Kumar, S; Lipton, SA; Rayudu, PV; Stamler, JS | 1 |
| Matoba, M; Nishikawa, T; Tomita, U | 1 |
| Leslie, SW; Randall, PK; Robichon, R | 1 |
| Fredholm, BB; Jin, S | 1 |
| Butterfield, BS; Grewal, RS; Stanley, BG | 1 |
| Fontana, G; Raiteri, M; Valenti, L | 1 |
| Churchill, D; Jarvis, CR; Lu, WY; MacDonald, JF; MacVicar, BA; Plant, JR; Xiong, ZG | 1 |
| Mancini, L; Mennini, T; Reggiani, A; Trist, D | 1 |
| Camarasa, J; Camins, A; Escubedo, E; Gabriel, C; Pallàs, M; Sureda, FX | 1 |
| Cugola, A; Donati, D; Micheli, F; Missio, A; Pecunioso, A; Reggiani, A; Tarzia, G | 1 |
| Chai, CY; Kuo, JS; Wang, Y; Wu, WC | 1 |
| Daggett, LP; Deal, C; Hess, SD; Johnson, EC; Lu, CC; Veliçelebi, G | 1 |
| Han, Y; Slaughter, MM | 1 |
| Ivanovic, A; Kuhse, J; Laube, B; Reiländer, H | 1 |
| Faull, RL; Layer, RT; Leiner, KA; McCabe, RT; Narang, N; Sofia, RD; Wamsley, JK | 1 |
| Boje, KM; Lakhman, SS | 1 |
| Reynolds, IJ; Sharma, TA | 1 |
| Foley, CM; Hasser, EM; Hay, M; Moffitt, JA | 1 |
| Bonagamba, LG; Haibara, AS; Machado, BH | 1 |
| Davidoff, RA; Hackman, JC; Holohean, AM | 1 |
| Bonnier, C; Delpech, A; Evrard, P; Gressens, P; Marret, S; Raymackers, JM | 1 |
| Abdrachmanova, G; Palecek, JI; Vlachová, V; Vyklick, L | 1 |
| Hinoi, E; Ogita, K; St'astny, F; Yoneda, Y | 1 |
| Bear, MF; Huganir, RL; Philpot, BD; Quinlan, EM | 1 |
| Bongianni, F; Deliagina, TG; Grillner, S | 1 |
| Foley, CM; Hasser, EM; Hay, M; Mueller, PJ; Vogl, HW | 1 |
| Liu, Y; von Euler, G | 1 |
| Ali, DW; Buss, RR; Drapeau, P; Saint-Amant, L | 1 |
| Bergamaschi, CT; Campos, RR; Lopes, OU | 1 |
| Hodgkins, PS; Lee, SC; Scharfman, HE; Schwarcz, R | 1 |
| VanDongen, AM; VanDongen, HM; Wood, MW | 1 |
| Bertrand, S; Cazalets, JR | 1 |
| Chiang, AS; Lee, WS; Liu, HP; Pszczolkowski, MA | 1 |
| Dohovics, R; Hermann, A; Janáky, R; Oja, SS; Saransaari, P; Shaw, CA; Varga, V | 1 |
| Devau, G | 1 |
| Harkin, A; Nowak, G; Paul, IA | 1 |
| Hamba, M; Onodera, K; Takahashi, T | 1 |
| Bunney, BS; Shi, WX; Zhang, XX | 1 |
| Li, Y; Nowak, G; Paul, IA | 1 |
| Arnarsson, A; Eysteinsson, T | 1 |
| Haberek, G; Tomczyk, T; Turski, WA; Urbanska, EM; Wielosz, M; Zuchora, B | 1 |
| Nowak, G; Popik, P; Wróbel, M | 1 |
| Dannhardt, G; Kohl, BK; Parsons, CG; von Gruchalla, M | 1 |
| Battaglia, G; Hodgkins, PS; Kiss, C; Nicoletti, F; Rassoulpour, A; Schwarcz, R; Wu, HQ | 1 |
| Senra-Vidal, A; Sierra-Marcuño, G; Sierra-Paredes, G | 1 |
| Hicks, TP; Ito, K | 1 |
| Kudo, N; Nakayama, K; Nishimaru, H | 1 |
| Albuquerque, EX; Alkondon, M; Hilmas, C; Pereira, EF; Rassoulpour, A; Schwarcz, R | 1 |
| Mirshahi, T; Ronald, KM; Woodward, JJ | 1 |
| Johnson, SW; Zheng, F | 1 |
| Blantz, RC; Deng, A; Munger, KA; Thomson, SC; Valdivielso, JM | 1 |
| Almeida, MC; Branco, LG; Carnio, EC; Paro, FM | 1 |
| Bradaïa, A; Trouslard, J | 1 |
| Wu, E | 1 |
| Ceresoli-Borroni, G; Guidetti, P; Kiss, C; Schwarcz, R; Zielke, CL; Zielke, HR | 1 |
| Cai, SX; Espitia, SA; Hawkinson, JE; Keana, JF; Kher, SM; Tran, M; Weber, E; Whittemore, ER; Woodward, RM; Zhou, ZL | 1 |
| Furukawa, H; Gouaux, E | 1 |
| Marszalec, W; Moriguchi, S; Narahashi, T; Yeh, JZ; Zhao, X | 1 |
| Bergamaschi, CT; Campos, RR; Carvalho, TH; Lopes, OU | 1 |
| Han, Y; Li, P; Slaughter, MM | 1 |
| Attwell, D; Billups, D | 1 |
| Johnson, MS; Moretti, L; Pentikäinen, OT; Settimo, L | 1 |
| Inoue, M; Kawamura, Y; Kudo, Y; Manita, S; Miyakawa, H; Nakamura, T | 1 |
| Branco, LG; de Paula, PM | 2 |
| Barth, A; Barth, L; Newell, DW; Nguyen, LB | 1 |
| Concas, A; Marino, G; Minei, R; Pierobon, P; Porcu, P; Sogliano, C; Tino, A; Tortiglione, C | 1 |
| Bhattacharyya, D; Blaise, MC; Pradhan, N; Sowdhamini, R | 1 |
| Bergeron, R; Krasteniakov, NV; Martina, M | 1 |
| Luchowski, P; Stazka, J; Urbanska, EM | 1 |
| Lamas, M; Lee-Rivera, I; López-Colomé, AM | 1 |
| Braga, VA; Machado, BH | 1 |
| Cao, H; Guo, JD; Ji, RR; Ren, WH; Sha, H; Wang, H; Wang, PF; Zhang, YQ; Zhao, ZQ | 1 |
| Bittencourt, AS; Carobrez, AP; Santos, P; Schenberg, LC | 1 |
| Solís, JM; Suárez, LM | 1 |
| Chen, HK; Su, CK | 1 |
| Akaike, A; Hama, Y; Katsuki, H; Kume, T; Suminaka, C; Tochikawa, Y | 1 |
| Han, TZ; Li, YH | 1 |
| Benedikz, E; Duan, J; Mo-Boquist, LL; Nilsson, A; Sundström, E | 1 |
| Smothers, CT; Woodward, JJ | 1 |
| Schlichter, R; Seddik, R; Trouslard, J | 1 |
| Chen, PE; Erreger, K; Geballe, MT; Katz, E; Le, P; Lee, CJ; Livesey, MR; O'Toole, KK; Snyder, JP; Traynelis, SF; Wyllie, DJ | 1 |
| Kamphausen, S; Pedroarena, CM | 1 |
| Han, TZ; Li, YH; Meng, K | 1 |
| Engberg, G; Erhardt, S; Linderholm, KR; Nilsson-Todd, LK; Schwieler, L | 1 |
| Cousins, SL; Kenny, AV; Pinho, L; Stephenson, FA | 1 |
| Cooke, JE; Ghavanini, AA; Mathers, DA; McCarthy, SM; Puil, E | 1 |
| Kussius, CL; Popescu, GK | 1 |
| de Novellis, V; Fernández-Sánchez, E; Gatta, L; Guida, F; Luongo, L; Maione, S; Marabese, I; Migliozzi, A; Palazzo, E; Rossi, C; Soukupova, M; Zafra, F | 1 |
| Chari, M; Cheung, GW; Kokorovic, A; Lai, TY; Lam, CK; Lam, TK; Su, BB; Wang, PY; Yang, CS | 1 |
| De Castro Bastos, L; Martins, MA; Melo, NE; Tonussi, CR | 1 |
| Cho, YH; Choi, D; Hwang, GS; Jung, J; Kim, J; Lee, HS; Park, HJ; Park, M; Ryu, DH; Shim, SB | 1 |
| Borker, P; Prodromou, ML; Salussolia, CL; Wollmuth, LP | 1 |
| He, YY; Jiang, WG; Liu, JF; Lu, L; Luo, YX; Wang, XY; Xue, LF; Xue, YX; Zhou, SJ | 1 |
| Dietz, B; Jovanovic, S; Milenkovic, I; Nerlich, J; Rübsamen, R; Wielsch, B | 1 |
| Choi, YH; Cui, J; Du, GH; Gao, XX; Li, ZY; Qin, XM; Tan, XJ; Tian, JS; Xing, J; Zheng, XY; Zhou, YZ | 1 |
| Fulop, F; Klivenyi, P; Szalardy, L; Toldi, J; Vecsei, L; Zadori, D | 1 |
| Chiang, HC; Luo, F; Sheng, J; Shin, W; Wu, LG; Wu, W; Wu, XS; Xue, L | 1 |
| Fukunaga, K; Moriguchi, S; Narahashi, T; Tanaka, T | 1 |
| McAllen, RM; McKinley, MJ; Tanaka, M | 1 |
| Brown, AM; Chen, S; Evans, RD; Hamner, MA; Ransom, BR; Yang, X; Ye, ZC | 1 |
| Milanese, M; Oliveri, M; Raiteri, L; Romei, C; Usai, C | 1 |
| Bi, K; Chen, X; Gu, L; Jiang, Y; Lu, H; Wang, X; Zhang, Y | 1 |
| Arora, S; Kaur, A; Kaur, T; Singh, AP | 1 |
| Bądzyńska, B; Kompanowska-Jezierska, E; Sadowski, J; Turski, WA; Zakrocka, I | 1 |
| Babic, S; Hachimine, P; Ranaldi, R; Seepersad, N | 1 |
| Abarca, J; Ferrada, C; Gysling, K; Sotomayor-Zárate, R | 1 |
| Acton, D; Miles, GB | 1 |
| Barbancho, MA; Carrillo de Albornoz, M; Dawid-Milner, MS; Díaz-Casares, A; González-García, M; López-González, MV; Peinado-Aragonés, CA | 1 |
| Cline, MA; Kadomoto, Y; Khan, MSI; Makino, R; Tachibana, T | 1 |
| Destreel, G; Engel, D; Seutin, V | 1 |
| Bansal, N; Chen, Y; Feldman, HI; Go, AS; Heckbert, SR; Hoofnagle, AN; Hsu, CY; Huber, MP; Kestenbaum, BR; Lash, JP; Mehta, RC; Paranji, RK; Porter, AC; Raj, DS; Seliger, SL; Srivastava, A; Waikar, SS; Wang, K; Weiss, NS; Zelnick, LR | 1 |
6 review(s) available for kynurenic acid and glycine
| Article | Year |
|---|---|
The glycine site on the NMDA receptor: structure-activity relationships and therapeutic potential.
Topics: Animals; Anti-Anxiety Agents; Antipsychotic Agents; Binding Sites; Cognition; Glycine; Humans; Kynurenic Acid; Neuroprotective Agents; Pyrrolidinones; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 1994 |
Effects of quinolinic and kynurenic acids on central neurons.
Topics: Action Potentials; Animals; Brain; Convulsants; gamma-Aminobutyric Acid; Glycine; Kynurenic Acid; Models, Neurological; N-Methylaspartate; Neurons; Quinolinic Acid; Quinolinic Acids; Rats; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Synaptic Transmission | 1991 |
The glycine coagonist site of the NMDA receptor.
Topics: Animals; Binding Sites; Brain; Glycine; Kainic Acid; Kynurenic Acid; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate | 1990 |
The glycine site on the NMDA receptor: pharmacology and involvement in NMDA receptor-mediated neurodegeneration.
Topics: Allosteric Site; Animals; Glycine; Kynurenic Acid; Nerve Degeneration; Receptors, N-Methyl-D-Aspartate | 1990 |
Quantitative aspects of tryptophan metabolism in humans and other species: a review.
Topics: Age Factors; Amides; Animals; Carbon Isotopes; Cats; Dogs; Female; Glucuronates; Glycine; Hippurates; Humans; Hydroxyindoleacetic Acid; Indican; Kynurenic Acid; Kynurenine; Lysine; Male; Mice; Niacinamide; Nicotinic Acids; ortho-Aminobenzoates; Pyridines; Pyridones; Pyridoxine; Rats; Serotonin; Sex Factors; Species Specificity; Swine; Time Factors; Tryptophan; Xanthurenates | 1971 |
Manipulating kynurenic acid levels in the brain - on the edge between neuroprotection and cognitive dysfunction.
Topics: Binding Sites; Brain; Cognition Disorders; Glycine; Humans; Kynurenic Acid | 2012 |
1 trial(s) available for kynurenic acid and glycine
| Article | Year |
|---|---|
Effect of l-tryptophan and its metabolites on food passage from the crop in chicks.
Topics: Administration, Oral; Alanine; Animals; Asparagine; Chickens; Crop, Avian; Gastrointestinal Motility; Glycine; Kynurenic Acid; Male; Quinolinic Acid; Tryptophan | 2018 |
259 other study(ies) available for kynurenic acid and glycine
| Article | Year |
|---|---|
Induction of feeding by 7-chlorokynurenic acid, a strychnine-insensitive glycine binding site antagonist.
Topics: Analysis of Variance; Animals; Ataxia; Dose-Response Relationship, Drug; Feeding Behavior; Glycine; Injections, Intraventricular; Kynurenic Acid; Male; Muscle Contraction; Rats; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Serine; Strychnine | 1992 |
Mechanism of glycine protection in hypoxic injury: analogies with glycine receptor.
Topics: Animals; Dose-Response Relationship, Drug; Glycine; Hypoxia; In Vitro Techniques; Kidney; Kynurenic Acid; Male; Perfusion; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, Neurotransmitter; Serine | 1992 |
A glycine antagonist reduces ischemia-induced CA1 cell loss in vivo.
Topics: Animals; Glycine; Hippocampus; Injections, Intraventricular; Ischemic Attack, Transient; Kynurenic Acid; Male; Pyramidal Tracts; Rats; Rats, Wistar; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures | 1992 |
L-homocysteic acid selectively activates N-methyl-D-aspartate receptors of rat retinal ganglion cells.
Topics: 2-Amino-5-phosphonovalerate; Animals; Evoked Potentials; Glycine; Homocysteine; Kynurenic Acid; Rats; Receptors, N-Methyl-D-Aspartate; Retinal Ganglion Cells; Stimulation, Chemical | 1992 |
In vitro and in vivo characterization of the NMDA receptor-linked strychnine-insensitive glycine site.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Dizocilpine Maleate; Glycine; Kynurenic Acid; Male; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures; Serine; Stereoisomerism; Strychnine | 1992 |
Thiokynurenates prevent excitotoxic neuronal death in vitro and in vivo by acting as glycine antagonists and as inhibitors of lipid peroxidation.
Topics: Animals; Cell Survival; Corpus Striatum; Glutamates; Glutamic Acid; Glycine; Kynurenic Acid; Lipid Peroxidation; Male; Neurons; Quinolinic Acid; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1992 |
A rapid filtration assay for the glycine binding site on the NMDA receptor in rat cortical membranes using [3H]dichlorokynurenic acid.
Topics: Animals; Binding Sites; Cerebral Cortex; Filtration; Glycine; In Vitro Techniques; Kynurenic Acid; Male; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tritium | 1992 |
NMDA receptor mediates dopamine release in the striatum of unanesthetized rats as measured by brain microdialysis.
Topics: 2-Amino-5-phosphonovalerate; Animals; Atropine; Brain Chemistry; Corpus Striatum; Dialysis; Dopamine; Glycine; Kynurenic Acid; Magnesium; Male; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Tetrodotoxin | 1992 |
Kynurenic acid analogues with improved affinity and selectivity for the glycine site on the N-methyl-D-aspartate receptor from rat brain.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Brain; Cell Membrane; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Evoked Potentials; Glycine; Hippocampus; Ibotenic Acid; Kainic Acid; Kinetics; Kynurenic Acid; Male; Neurons; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Tritium | 1992 |
Specificity and potency of N-methyl-D-aspartate glycine site antagonists and of mephenesin on the rat spinal cord in vitro.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Glycine; Ibotenic Acid; Indoles; Kynurenic Acid; Mephenesin; N-Methylaspartate; Pyrrolidinones; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1992 |
Stimulation of noradrenaline release in human cerebral cortex mediated by N-methyl-D-aspartate (NMDA) and non-NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adult; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Cerebral Cortex; Dizocilpine Maleate; Dose-Response Relationship, Drug; Female; Glycine; Humans; Ibotenic Acid; Kainic Acid; Kynurenic Acid; Magnesium; Male; N-Methylaspartate; Norepinephrine; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Tetrodotoxin; Tritium | 1992 |
Involvement of glycine site associated with the NMDA receptor in hippocampal long-term potentiation and acquisition of spatial memory in rats.
Topics: Animals; Binding Sites; Brain Mapping; Cerebral Ventricles; Evoked Potentials; Glycine; Hippocampus; In Vitro Techniques; Injections, Intraventricular; Kynurenic Acid; Male; Memory; Pyramidal Tracts; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Space Perception; Time Factors | 1992 |
Glycine is required for NMDA receptor activation: electrophysiological evidence from intact rat hippocampus.
Topics: Animals; Dizocilpine Maleate; Electric Stimulation; Electrophysiology; Evoked Potentials; Glycine; Hippocampus; Iontophoresis; Ketamine; Kynurenic Acid; Magnesium; Male; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate; Time Factors | 1992 |
Glycine enhances extracellular 45Ca2+ response to NMDA application investigated with microdialysis of rabbit hippocampus in vivo.
Topics: Amino Acids; Animals; Calcium; Calcium Radioisotopes; Dialysis; Drug Synergism; Extracellular Space; Glycine; Hippocampus; Kynurenic Acid; N-Methylaspartate; Rabbits; Receptors, N-Methyl-D-Aspartate; Serine | 1992 |
2-Carboxytetrahydroquinolines. Conformational and stereochemical requirements for antagonism of the glycine site on the NMDA receptor.
Topics: Animals; Binding Sites; Cell Membrane; Cerebral Cortex; Glycine; Hippocampus; Kynurenic Acid; Magnetic Resonance Spectroscopy; Molecular Conformation; Molecular Structure; Quinolines; Rats; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; X-Ray Diffraction | 1992 |
4-Amido-2-carboxytetrahydroquinolines. Structure-activity relationships for antagonism at the glycine site of the NMDA receptor.
Topics: Aminoquinolines; Animals; Binding Sites; Cell Membrane; Cerebral Cortex; Glycine; Kynurenic Acid; Models, Molecular; Molecular Conformation; Molecular Structure; N-Methylaspartate; Quinolines; Rats; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 1992 |
The influence of strychnine-insensitive glycine receptor agonists and antagonists on generalized seizure thresholds.
Topics: Alanine; Amygdala; Animals; Glycine; Kindling, Neurologic; Kynurenic Acid; Male; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures; Serine; Strychnine | 1991 |
Anticonvulsant drug potentiation by glycine in maximal electroshock seizures is mimicked by D-serine and antagonized by 7-chlorokynurenic acid.
Topics: Animals; Anticonvulsants; Carbamazepine; Drug Synergism; Electroshock; Glycine; Kynurenic Acid; Male; Phenobarbital; Phenytoin; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures; Serine | 1991 |
Evidence for involvement of endogenous glycine in the induction of long-term potentiation in the dentate gyrus of anesthetized rats.
Topics: Anesthesia; Animals; Electric Stimulation; Glycine; Hippocampus; Kynurenic Acid; Male; Neuronal Plasticity; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Serine; Synapses; Synaptic Transmission; Time Factors | 1991 |
Effects of (+)-HA-966 and 7-chlorokynurenic acid on the kinetics of N-methyl-D-aspartate receptor agonist responses in rat cultured cortical neurons.
Topics: Animals; Binding, Competitive; Cells, Cultured; Cerebral Cortex; Glutamates; Glutamic Acid; Glycine; Kinetics; Kynurenic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Osmolar Concentration; Pyrrolidinones; Rats; Receptors, N-Methyl-D-Aspartate; Sodium | 1991 |
Glutamate and glycine co-activate while polyamines merely modulate the NMDA receptor complex.
Topics: 2-Amino-5-phosphonovalerate; Adrenergic alpha-Antagonists; Animals; Biguanides; Binding, Competitive; Biogenic Polyamines; Biotransformation; Brain; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; Kynurenic Acid; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine | 1991 |
Excitatory and inhibitory autaptic currents in isolated hippocampal neurons maintained in cell culture.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium Chloride; Cells, Cultured; Electric Conductivity; Electric Stimulation; Electrophysiology; Glycine; Hippocampus; Kynurenic Acid; Magnesium Chloride; Membrane Potentials; Neuroglia; Neurons; Receptors, GABA-A; Receptors, Glutamate; Receptors, Neurotransmitter; Strychnine | 1991 |
Kinetic mechanisms of glycine requirement for N-methyl-D-aspartate channel activation.
Topics: Animals; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Kinetics; Kynurenic Acid; Male; Models, Biological; Prosencephalon; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Synaptosomes | 1991 |
Evidence for heterogenous glycine domains but conserved multiple states of the excitatory amino acid recognition site of the NMDA receptor: regional binding studies with [3H]glycine and [3H]L-glutamate.
Topics: Animals; Autoradiography; Binding, Competitive; Cerebellar Cortex; Cerebral Cortex; Cycloserine; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; Kynurenic Acid; Ligands; Male; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Serine | 1991 |
An excitatory amino acid(s) in the ventrolateral medulla is (are) required for breathing to occur in the anesthetized cat.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids; Animals; Cats; Female; Glycine; Kynurenic Acid; Male; Medulla Oblongata; Microinjections; Piperazines; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Respiration | 1991 |
An arthropod NMDA receptor.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Astacoidea; Cesium; Evoked Potentials; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Immunoenzyme Techniques; Interneurons; Kynurenic Acid; Magnesium; Membrane Potentials; N-Methylaspartate; Photic Stimulation; Receptors, N-Methyl-D-Aspartate; Vision, Ocular | 1991 |
Polyamine effects upon N-methyl-D-aspartate receptor functioning: differential alteration by glutamate and glycine site antagonists.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding Sites; Cell Membrane; Cerebral Cortex; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Hippocampus; Kinetics; Kynurenic Acid; Male; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Spermidine | 1991 |
Microinjection of glycine into the nucleus ambiguus elicits tachycardia in spinal rats.
Topics: Animals; Blood Pressure; Glutamates; Glutamic Acid; Glycine; Heart Rate; Kynurenic Acid; Male; Medulla Oblongata; Microinjections; Rats; Rats, Inbred Strains; Reference Values; Spinal Cord | 1991 |
The glycine site of the N-methyl-D-aspartate receptor channel: differences between the binding of HA-966 and of 7-chlorokynurenic acid.
Topics: Animals; Binding Sites; Glycine; Ion Channels; Kynurenic Acid; Phencyclidine; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Strychnine | 1990 |
Competitive antagonists and partial agonists at the glycine modulatory site of the mouse N-methyl-D-aspartate receptor.
Topics: Action Potentials; Animals; Brain; Cells, Cultured; Cerebral Cortex; Cycloserine; Diencephalon; Glycine; Ion Channels; Kynurenic Acid; Mice; N-Methylaspartate; Neurons; Pyrrolidinones; Receptors, N-Methyl-D-Aspartate | 1990 |
Kinetic analysis of antagonist action at N-methyl-D-aspartic acid receptors. Two binding sites each for glutamate and glycine.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding Sites; Biophysical Phenomena; Biophysics; Cells, Cultured; Glutamates; Glutamic Acid; Glycine; Hippocampus; Ion Channels; Kinetics; Kynurenic Acid; Models, Neurological; Piperazines; Receptors, N-Methyl-D-Aspartate | 1991 |
GABA release from mouse striatal neurons in primary culture as a test for the functional activity of N-methyl-D-aspartate (NMDA) antagonists.
Topics: Animals; Cells, Cultured; Corpus Striatum; Dizocilpine Maleate; Female; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Ion Channels; Kynurenic Acid; Ligands; Mice; N-Methylaspartate; Neurons; Pregnancy; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1991 |
Thiokynurenates: a new group of antagonists of the glycine modulatory site of the NMDA receptor.
Topics: Animals; Binding Sites; Cerebral Cortex; Chlorine; Fluorine; Glutamates; Glutamic Acid; Glycine; Guinea Pigs; Ileum; Ion Channels; Kynurenic Acid; Mice; Muscle Contraction; Myenteric Plexus; Phencyclidine; Radioimmunoassay; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 1991 |
Glycine microinjected into nucleus tractus solitarii of rat acts through cholinergic mechanisms.
Topics: Acetylcholine; Animals; Blood Pressure; Choline; Glycine; Heart Rate; Kynurenic Acid; Male; Medulla Oblongata; Microinjections; N-Methylaspartate; Physostigmine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Receptors, N-Methyl-D-Aspartate | 1991 |
Kynurenic acid derivatives. Structure-activity relationships for excitatory amino acid antagonism and identification of potent and selective antagonists at the glycine site on the N-methyl-D-aspartate receptor.
Topics: Animals; Binding, Competitive; Glycine; Indicators and Reagents; Kynurenic Acid; Molecular Structure; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 1991 |
Antagonism at the glycine site on the NMDA receptor reduces spinal nociception in the rat.
Topics: Anesthesia; Animals; Glycine; Kynurenic Acid; Nerve Fibers; Nerve Fibers, Myelinated; Neurons; Nociceptors; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1991 |
7-Chlorokynurenic acid blocks NMDA receptor-induced fictive locomotion in lamprey--evidence for a physiological role of the glycine site.
Topics: Animals; Glycine; Kynurenic Acid; Lampreys; Locomotion; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1991 |
[3H]5,7-dichlorokynurenic acid, a novel radioligand labels NMDA receptor-associated glycine binding sites.
Topics: Allosteric Regulation; Animals; Binding Sites; Brain; Glycine; In Vitro Techniques; Kynurenic Acid; Ligands; Male; Polyamines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Strychnine; Synaptosomes | 1991 |
[3H] 5,7-dichlorokynurenic acid, a high affinity ligand for the NMDA receptor glycine regulatory site.
Topics: Animals; Glycine; Kynurenic Acid; Ligands; Molecular Structure; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Tritium | 1991 |
Endogenous glycine modulates N-methyl-D-aspartate-evoked release of adenosine and [3H]noradrenaline from rat cortical slices.
Topics: Adenosine; Animals; Cerebral Cortex; Glycine; In Vitro Techniques; Kynurenic Acid; Male; N-Methylaspartate; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Strychnine | 1991 |
Agonist-like character of the (R)-enantiomer of 1-hydroxy-3-amino-pyrrolid-2-one (HA-966).
Topics: Amino Acids; Amino Acids, Cyclic; Animals; Binding, Competitive; Dose-Response Relationship, Drug; Glycine; Kynurenic Acid; Male; Pyrrolidinones; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Spermine; Stereoisomerism; Synaptosomes | 1991 |
Identification of a novel structural class of positive modulators of the N-methyl-D-aspartate receptor, with actions mediated through the glycine recognition site.
Topics: Amino Acids; Animals; Brain; Dizocilpine Maleate; Glycine; In Vitro Techniques; Kinetics; Kynurenic Acid; Male; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Stereoisomerism; Structure-Activity Relationship; Synaptic Membranes | 1990 |
Rat pup isolation calls are reduced by functional antagonists of the NMDA receptor complex.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Amino Acids, Cyclic; Animals; Female; Glycine; Hippocampus; Kynurenic Acid; Male; N-Methylaspartate; Piperazines; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Social Isolation; Vocalization, Animal | 1990 |
Blockade of the glycine modulatory site of NMDA receptors modifies dynorphin-induced behavioral effects.
Topics: Animals; Dynorphins; Glycine; Indoles; Injections, Spinal; Kynurenic Acid; Male; Paralysis; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Concentration-jump experiments with NMDA antagonists in mouse cultured hippocampal neurons.
Topics: 2-Amino-5-phosphonovalerate; Alanine; Animals; Aspartic Acid; Cells, Cultured; Glycine; Hippocampus; Kynurenic Acid; Mice; N-Methylaspartate; Neurons; Osmolar Concentration; Piperazines | 1990 |
Glycine-insensitive NMDA-sensitive receptor expressed in Xenopus oocytes by guinea pig cerebellar mRNA.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Cerebellum; Electric Conductivity; Female; Glycine; Guinea Pigs; Kynurenic Acid; Magnesium; Male; Membrane Potentials; N-Methylaspartate; Oocytes; Phencyclidine; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; RNA, Messenger; Xenopus laevis | 1990 |
The glycine site modulates NMDA-mediated changes of intracellular free calcium in cultures of hippocampal neurons.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Calcium; Cells, Cultured; Embryo, Mammalian; Glycine; Hippocampus; Ketamine; Kinetics; Kynurenic Acid; Macromolecular Substances; N-Methylaspartate; Neurons; Rats; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Serine | 1990 |
Glycine synergistically potentiates the enhancement of LTP induced by a sulfhydryl reducing agent.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dithiothreitol; Drug Synergism; Evoked Potentials; Glycine; Hippocampus; In Vitro Techniques; Kynurenic Acid; Male; Pyramidal Tracts; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Strychnine | 1990 |
The glycine antagonist 7-chlorokynurenic acid blocks the effects of N-methyl-D-aspartate on agonist-stimulated phosphoinositide hydrolysis in guinea-pig brain slices.
Topics: Animals; Brain; Glutamates; Glutamic Acid; Glycine; Guinea Pigs; Hydrolysis; In Vitro Techniques; Kynurenic Acid; N-Methylaspartate; Phosphatidylinositols; Receptors, N-Methyl-D-Aspartate | 1990 |
Dual effect of glycine on NMDA-induced neurotoxicity in rat cortical cultures.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cells, Cultured; Cerebral Cortex; Drug Synergism; gamma-Aminobutyric Acid; Glycine; Kynurenic Acid; L-Lactate Dehydrogenase; N-Methylaspartate; Nerve Degeneration; Neurons; Oocytes; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Taurine; Xenopus | 1990 |
Ethanol inhibits NMDA-stimulated neurite growth by sensory neurons in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cells, Cultured; Chick Embryo; Ethanol; Ganglia, Spinal; Glycine; Kynurenic Acid; Magnesium; N-Methylaspartate; Neurites; Neurons, Afferent | 1990 |
Role of glycine in the N-methyl-D-aspartate-mediated neuronal cytotoxicity.
Topics: Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Glycine; Kynurenic Acid; N-Methylaspartate; Neurons; Piperazines; Pyrrolidinones; Serine | 1990 |
4-[(Carboxymethyl)oxy]- and 4-[(carboxymethyl)amino]-5,7-dichloroquinoline-2-carboxylic acid: new antagonists of the strychnine-insensitive glycine binding site on the N-methyl-D-aspartate receptor complex.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Glycine; Kynurenic Acid; Molecular Structure; Quinolines; Rats; Receptors, N-Methyl-D-Aspartate; Strychnine | 1990 |
Reduction of NMDA receptors with dithiothreitol increases [3H]-MK-801 binding and NMDA-induced Ca2+ fluxes.
Topics: Animals; Calcium; Dithionitrobenzoic Acid; Dithiothreitol; Dizocilpine Maleate; Fluorescence; Fura-2; Glutamates; Glycine; In Vitro Techniques; Kynurenic Acid; N-Methylaspartate; Pipecolic Acids; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine | 1990 |
The effect of NMDA receptor glycine site antagonists on hypoxia-induced neurodegeneration of rat cortical cell cultures.
Topics: Animals; Binding Sites; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Fetus; Glycine; Hypoxia; Kinetics; Kynurenic Acid; L-Lactate Dehydrogenase; Nerve Degeneration; Neurons; Phosphopyruvate Hydratase; Pyrrolidinones; Rats; Receptors, N-Methyl-D-Aspartate | 1990 |
5,7-Dichlorokynurenic acid, a potent and selective competitive antagonist of the glycine site on NMDA receptors.
Topics: Animals; Binding, Competitive; Brain; Evoked Potentials; Female; Glycine; Kinetics; Kynurenic Acid; N-Methylaspartate; Oocytes; Rats; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Structure-Activity Relationship; Xenopus | 1990 |
Selective blockade of N-methyl-D-aspartate (NMDA)-induced convulsions by NMDA antagonists and putative glycine antagonists: relationship with phencyclidine-like behavioral effects.
Topics: Animals; Aspartic Acid; Dose-Response Relationship, Drug; Glycine; Kainic Acid; Kynurenic Acid; Male; Mice; Motor Activity; N-Methylaspartate; Oxadiazoles; Phencyclidine; Pyrrolidinones; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures | 1990 |
Desensitization of NMDA receptors does not proceed in the presence of kynurenate.
Topics: Animals; Glycine; Hippocampus; In Vitro Techniques; Kynurenic Acid; Membrane Potentials; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Activation of the glycine site in the NMDA receptor is necessary for the induction of LTP.
Topics: Action Potentials; Animals; Glycine; Hippocampus; Kynurenic Acid; Neuronal Plasticity; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synaptic Transmission | 1990 |
Glycine-related amino acids stereoselectively affect N-methyl-D-aspartate receptor-mediated contractions of guinea pig ileum: comparison with the inhibition of strychnine-insensitive [3H]glycine binding to rat cortical membranes.
Topics: Amino Acids; Animals; Cerebral Cortex; Glycine; Guinea Pigs; Ileum; In Vitro Techniques; Kynurenic Acid; Male; Membranes; Muscle, Smooth; Myenteric Plexus; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Stereoisomerism; Strychnine; Synaptosomes | 1990 |
Glycine site associated with the NMDA receptor modulates long-term potentiation.
Topics: Adaptation, Physiological; Animals; Glycine; Hippocampus; Kynurenic Acid; Male; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Modulation of N-methyl-D-aspartic acid receptor desensitization by glycine in mouse cultured hippocampal neurones.
Topics: Animals; Cells, Cultured; Electrophysiology; Glycine; Hippocampus; Kynurenic Acid; Mice; Mice, Inbred Strains; Neurons; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Activity of 5,7-dichlorokynurenic acid, a potent antagonist at the N-methyl-D-aspartate receptor-associated glycine binding site.
Topics: Animals; Calcium; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Kynurenic Acid; Male; N-Methylaspartate; Norepinephrine; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Rostral ventrolateral medulla and sympathorespiratory integration in rats.
Topics: Animals; Blood Pressure; Chemoreceptor Cells; gamma-Aminobutyric Acid; Glycine; Injections; Kynurenic Acid; Male; Medulla Oblongata; Periodicity; Phrenic Nerve; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, Neurotransmitter; Respiration; Sympathetic Nervous System | 1990 |
Activation of the glycine site associated with the NMDA receptor is required for induction of LTP in neonatal hippocampus.
Topics: Animals; Animals, Newborn; Electric Stimulation; Electrophysiology; Glycine; Hippocampus; In Vitro Techniques; Kynurenic Acid; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Serine | 1990 |
Evidence for a role of glycine in area tempestas for triggering convulsive seizures.
Topics: Animals; Anticonvulsants; Bicuculline; Carbachol; Cerebral Cortex; Glycine; Kainic Acid; Kynurenic Acid; Male; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures | 1990 |
Glycine antagonists block the induction of long-term potentiation in CA1 of rat hippocampal slices.
Topics: Action Potentials; Adaptation, Physiological; Amino Acids; Animals; Cycloleucine; Glycine; Hippocampus; In Vitro Techniques; Kynurenic Acid; Rats | 1990 |
Quinoxalines interact with the glycine recognition site of NMDA receptors: studies in guinea-pig myenteric plexus and in rat cortical membranes.
Topics: Animals; Cerebral Cortex; Glycine; Guinea Pigs; In Vitro Techniques; Ion Channels; Kinetics; Kynurenic Acid; Male; Myenteric Plexus; Quinoxalines; Rats; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Strychnine | 1989 |
Effect of 7-chloro kynurenic acid on glycine modulation of the N-methyl-D-aspartate response in guinea-pig myenteric plexus.
Topics: Animals; Aspartic Acid; Glycine; Guinea Pigs; In Vitro Techniques; Kynurenic Acid; Male; Myenteric Plexus; N-Methylaspartate; Serine | 1989 |
Effect of MK-801, kynurenate, glycine, dextrorphan and 4-acetylpyridine on striatal toxicity of quinolinate.
Topics: Animals; Choline O-Acetyltransferase; Corpus Striatum; Dextrorphan; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Glutamate Decarboxylase; Glycine; Kynurenic Acid; Male; Neurotoxins; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains | 1989 |
A glycine site associated with N-methyl-D-aspartic acid receptors: characterization and identification of a new class of antagonists.
Topics: Animals; Binding Sites; Chemical Phenomena; Chemistry; Glycine; Kynurenic Acid; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Glycine enhances NMDA-receptor mediated synaptic potentials in neocortical slices.
Topics: Action Potentials; Animals; Cerebral Cortex; Female; Glycine; In Vitro Techniques; Kynurenic Acid; Male; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses; Synaptic Transmission | 1989 |
Glycine reverses 7-Cl kynurenate blockade of glutamate neurotoxicity in cell culture.
Topics: Animals; Cells, Cultured; Drug Interactions; Glutamates; Glycine; Hippocampus; Kynurenic Acid; L-Lactate Dehydrogenase; Nerve Degeneration; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Selectivity of quinoxalines and kynurenines as antagonists of the glycine site on N-methyl-D-aspartate receptors.
Topics: Animals; Aspartic Acid; Binding Sites; Binding, Competitive; Biological Assay; Glycine; Kainic Acid; Kynurenic Acid; N-Methylaspartate; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Structure-Activity Relationship; Xenopus laevis | 1989 |
Schild plot analysis of glycine and kynurenic acid at the N-methyl-D-aspartate excitatory amino acid receptor.
Topics: Animals; Glycine; Hippocampus; In Vitro Techniques; Kynurenic Acid; Male; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Sodium | 1989 |
Glycine reverses 7-chlorokynurenic acid-induced inhibition of [3H]MK-801 binding.
Topics: Animals; Dibenzocycloheptenes; Dizocilpine Maleate; Glycine; Kynurenic Acid; Male; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine | 1989 |
Spermine enhances binding to the glycine site associated with the N-methyl-D-aspartate receptor complex.
Topics: Animals; Dibenzocycloheptenes; Dizocilpine Maleate; Glycine; Kinetics; Kynurenic Acid; Magnesium; Rats; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spermine | 1989 |
CNQX (6-cyano-7-nitroquinoxaline-2,3-dione) antagonizes NMDA-evoked [3H]GABA release from cultured cortical neurons via an inhibitory action at the strychnine-insensitive glycine site.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Cells, Cultured; Cerebral Cortex; gamma-Aminobutyric Acid; Glycine; Kainic Acid; Kynurenic Acid; N-Methylaspartate; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Strychnine | 1989 |
Glycine and kynurenate modulate the glutamate receptors in the myenteric plexus and in cortical membranes.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Cerebral Cortex; Glycine; Guinea Pigs; In Vitro Techniques; Kynurenic Acid; Myenteric Plexus; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1989 |
Different modes of action of 3-amino-1-hydroxy-2-pyrrolidone (HA-966) and 7-chlorokynurenic acid in the modulation of N-methyl-D-aspartate-sensitive glutamate receptors.
Topics: Animals; Dibenzocycloheptenes; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; Kynurenic Acid; Piperazines; Protein Conformation; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Glycine potentiates the NMDA-induced release of dopamine through a strychnine-insensitive site in the rat striatum.
Topics: Animals; Aspartic Acid; Corpus Striatum; Dibenzocycloheptenes; Dizocilpine Maleate; Dopamine; Drug Synergism; Glycine; In Vitro Techniques; Kynurenic Acid; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Strychnine | 1989 |
Effect of glycine and glycine receptor antagonists on NMDA-induced brain injury.
Topics: Animals; Aspartic Acid; Brain; Dose-Response Relationship, Drug; Glycine; Kynurenic Acid; N-Methylaspartate; Organ Size; Rats; Rats, Inbred Strains | 1989 |
7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex.
Topics: Animals; Animals, Newborn; Aspartic Acid; Cells, Cultured; Cerebral Cortex; Electric Conductivity; Glycine; In Vitro Techniques; Kynurenic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1988 |
Kynurenic acid antagonises responses to NMDA via an action at the strychnine-insensitive glycine receptor.
Topics: Animals; Aspartic Acid; Dose-Response Relationship, Drug; Glycine; In Vitro Techniques; Kynurenic Acid; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, Neurotransmitter; Serine; Strychnine | 1988 |
Sites of antagonist action on N-methyl-D-aspartic acid receptors studied using fluctuation analysis and a rapid perfusion technique.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Binding Sites; Binding, Competitive; Cations, Divalent; Cells, Cultured; Glycine; Hippocampus; Ketamine; Kynurenic Acid; Magnesium; Mice; Mice, Inbred C57BL; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine; Zinc | 1988 |
Antagonism of seizures induced by the administration of the endogenous convulsant quinolinic acid into rat brain ventricles.
Topics: Animals; Anticonvulsants; Diazepam; gamma-Aminobutyric Acid; Glycine; Injections, Intraventricular; Kynurenic Acid; Male; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Seizures; Taurine | 1986 |
NMDA-induced hippocampal [3H]norepinephrine release is modulated by glycine.
Topics: Animals; Aspartic Acid; Glycine; Hippocampus; In Vitro Techniques; Kynurenic Acid; N-Methylaspartate; Norepinephrine; Radioligand Assay; Rats | 1988 |
Role of the rostral ventrolateral medulla in maintenance of blood pressure in rats with Goldblatt hypertension.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Heart Rate; Hexamethonium; Hypertension, Renovascular; Kynurenic Acid; Male; Medulla Oblongata; Microinjections; Rats; Rats, Wistar; Receptors, Glutamate | 1995 |
N-methyl-D-aspartate receptors: different subunit requirements for binding of glutamate antagonists, glycine antagonists, and channel-blocking agents.
Topics: Binding Sites; Cells, Cultured; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Glycine; Humans; Ion Channels; Kynurenic Acid; Receptors, N-Methyl-D-Aspartate; Transfection | 1994 |
Excitatory amino acid neurotransmission through both NMDA and non-NMDA receptors is involved in the anticonvulsant activity of felbamate in DBA/2 mice.
Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Binding, Competitive; Disease Models, Animal; Dose-Response Relationship, Drug; Felbamate; Female; Glycine; Injections, Intraperitoneal; Injections, Intraventricular; Kynurenic Acid; Male; Mice; Mice, Inbred DBA; N-Methylaspartate; Phenylcarbamates; Propylene Glycols; Quinoxalines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures; Serine; Stereoisomerism; Synaptic Transmission | 1994 |
Allosteric interactions and modulator requirement for NMDA receptor function.
Topics: Allosteric Regulation; Animals; Brain Chemistry; Dizocilpine Maleate; Glutamic Acid; Glycine; In Vitro Techniques; Ion Channels; Kynurenic Acid; Male; Membranes; Protein Conformation; Rats; Rats, Sprague-Dawley; Receptors, Biogenic Amine; Receptors, N-Methyl-D-Aspartate; Spermine | 1994 |
Modulation by magnesium of the affinity of NMDA receptors for glycine in murine hippocampal neurones.
Topics: Animals; Calcium; Cells, Cultured; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Glycine Agents; Hippocampus; In Vitro Techniques; Ion Channel Gating; Kynurenic Acid; Magnesium; Mice; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1995 |
In vitro pharmacology of ACEA-1021 and ACEA-1031: systemically active quinoxalinediones with high affinity and selectivity for N-methyl-D-aspartate receptor glycine sites.
Topics: Animals; Binding Sites; Brain; Cells, Cultured; Cloning, Molecular; DNA, Complementary; Electrophysiology; Female; Glycine; Kynurenic Acid; Neurons; Oocytes; Quinoxalines; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; RNA, Complementary; RNA, Messenger; Transcription, Genetic; Xenopus laevis | 1995 |
Putative cognition enhancers reverse kynurenic acid antagonism at hippocampal NMDA receptors.
Topics: Animals; Cognition; Cycloserine; Glycine; Hippocampus; In Vitro Techniques; Kynurenic Acid; Male; Norepinephrine; Psychotropic Drugs; Pyrrolidines; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1995 |
Evidence for glycine modulation of excitatory synaptic inputs to retinal ganglion cells.
Topics: Ambystoma; Animals; Biological Transport; Dendrites; Dose-Response Relationship, Drug; Evoked Potentials; Glycine; In Vitro Techniques; Kinetics; Kynurenic Acid; Light; Patch-Clamp Techniques; Potassium Chloride; Receptors, N-Methyl-D-Aspartate; Retinal Ganglion Cells; Serine; Stereoisomerism; Synapses; Synaptic Transmission; Time Factors | 1995 |
Glycine site NMDA receptor antagonists provide protection against ischemia-induced neuronal damage in hippocampal slice cultures.
Topics: Animals; Brain Ischemia; Cell Death; Dizocilpine Maleate; Glycine; Glycine Agents; Hippocampus; Kynurenic Acid; Neurons; Organ Culture Techniques; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 1995 |
Swim stress increases the potency of glycine at the N-methyl-D-aspartate receptor complex.
Topics: Animals; Binding, Competitive; Frontal Lobe; Glycine; Kynurenic Acid; Male; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Stress, Physiological; Swimming | 1995 |
NMDA-mediated potentiation of the afferent synapse in the inner ear.
Topics: 2-Amino-5-phosphonovalerate; Ambystoma; Amplifiers, Electronic; Animals; Dizocilpine Maleate; Electrophysiology; Glycine; In Vitro Techniques; Kynurenic Acid; N-Methylaspartate; Neurons, Afferent; Physical Stimulation; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Synapses; Vestibule, Labyrinth | 1994 |
Anxiolytic effect of glycine antagonists microinjected into the dorsal periaqueductal grey.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Conditioning, Operant; Electric Stimulation; Glycine; Kynurenic Acid; Male; Microinjections; Periaqueductal Gray; Pyrrolidinones; Rats; Rats, Wistar; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 1994 |
Glycine-induced CA1 excitotoxicity in the rat hippocampal slice.
Topics: Animals; Anticonvulsants; Chlorides; Drug Synergism; Evoked Potentials; Felbamate; Glycine; Hippocampus; Histidine; In Vitro Techniques; Kynurenic Acid; Magnesium Sulfate; Male; Phenylcarbamates; Propylene Glycols; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Zinc Compounds | 1994 |
The glycine antagonist and free radical scavenger 7-Cl-thio-kynurenate reduces CA1 ischemic damage in the gerbil.
Topics: Animals; Body Temperature; Female; Free Radical Scavengers; Gene Expression; Gerbillinae; Glycine; Hippocampus; In Situ Hybridization; Ischemic Attack, Transient; Kynurenic Acid; Pyramidal Cells; Receptors, N-Methyl-D-Aspartate | 1994 |
N-methyl-D-aspartic acid/glycine interactions on the control of 5-hydroxytryptamine release in raphe primary cultures.
Topics: Animals; Cells, Cultured; Embryo, Mammalian; Female; Gestational Age; Glutamates; Glutamic Acid; Glycine; Kinetics; Kynurenic Acid; N-Methylaspartate; Pregnancy; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Rhombencephalon; Serotonin; Strychnine; Valine | 1993 |
Adaptation of the NMDA receptor in rat cortex following chronic electroconvulsive shock or imipramine.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cerebral Cortex; Electroshock; Glycine; Imipramine; In Vitro Techniques; Kynurenic Acid; Male; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1993 |
A comparison of the effects of ethanol and the competitive glycine antagonist 7-chlorokynurenic acid on N-methyl-D-aspartic acid-induced neurotransmitter release from rat hippocampal slices.
Topics: Animals; Dose-Response Relationship, Drug; Ethanol; Glycine; Hippocampus; In Vitro Techniques; Kynurenic Acid; Male; N-Methylaspartate; Neurotransmitter Agents; Norepinephrine; Rats; Rats, Sprague-Dawley; Serine | 1994 |
Evidence for NMDA receptor in the afferent synaptic transmission of the vestibular system.
Topics: 2-Amino-5-phosphonovalerate; Ambystoma; Animals; Glycine; Hair Cells, Auditory; In Vitro Techniques; Kynurenic Acid; Magnesium; N-Methylaspartate; Nerve Fibers; Neurons, Afferent; Receptors, N-Methyl-D-Aspartate; Semicircular Canals; Synapses; Synaptic Transmission; Vestibule, Labyrinth | 1994 |
Complex allosteric modulation of the binding of the NMDA receptor antagonist [3H]CGP39653.
Topics: 2-Amino-5-phosphonovalerate; Allosteric Regulation; Animals; Biguanides; Binding Sites; Glycine; In Vitro Techniques; Kynurenic Acid; Male; Piperidines; Prosencephalon; Putrescine; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermine | 1994 |
Activation-related and activation-independent effects of polyamines on phencyclidine receptor binding within the N-methyl-D-aspartate receptor complex.
Topics: Animals; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; Kinetics; Kynurenic Acid; Male; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Phencyclidine; Spermidine | 1994 |
Preferential induction by stress of the N-methyl-D-aspartate recognition domain in discrete structures of rat brain.
Topics: 2-Amino-5-phosphonovalerate; Adrenal Cortex Hormones; Animals; Autoradiography; Behavior, Animal; Brain Chemistry; Cerebellum; Corpus Striatum; Cycloheximide; Dizocilpine Maleate; Dose-Response Relationship, Drug; Glycine; Hypothalamus; Kynurenic Acid; Male; N-Methylaspartate; Rats; Rats, Wistar; Stress, Physiological; Tritium | 1994 |
Interaction of felbamate with [3H]DCKA-labeled strychnine-insensitive glycine receptors in human postmortem brain.
Topics: Adult; Aged; Anticonvulsants; Autopsy; Autoradiography; Binding, Competitive; Brain; Felbamate; Female; Glycine; Hippocampus; Humans; Kinetics; Kynurenic Acid; Male; Mesencephalon; Middle Aged; Neurons; Organ Specificity; Phenylcarbamates; Propylene Glycols; Radioligand Assay; Receptors, Glycine; Strychnine; Tritium | 1994 |
Anticonvulsant activity of antagonists and partial agonists for the NMDA receptor-associated glycine site in the kindling model of epilepsy.
Topics: Animals; Anticonvulsants; Cycloserine; Differential Threshold; Epilepsy; Female; Glycine; Kindling, Neurologic; Kynurenic Acid; Pyrrolidinones; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1994 |
Felbamate: interaction with glycine receptors in human cerebral cortex.
Topics: Adult; Aged; Anticonvulsants; Autoradiography; Cerebral Cortex; Felbamate; Glycine; Humans; Kynurenic Acid; Male; Middle Aged; Phenylcarbamates; Propylene Glycols; Receptors, Glycine; Strychnine | 1994 |
Intrahippocampal administration of a glycine site antagonist impairs working memory performance of rats.
Topics: Animals; Binding Sites; Glycine; Hippocampus; Kynurenic Acid; Male; Memory; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1994 |
Synergism between the NMDA receptor antagonistic effects of ifenprodil and the glycine antagonist, 7-chlorokynurenate, in vivo.
Topics: Animals; Chromatography, High Pressure Liquid; Drug Synergism; Glycine; Injections; Kynurenic Acid; Male; N-Methylaspartate; Neostriatum; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine | 1994 |
NMDA receptor activation by spermine requires glutamate but not glycine.
Topics: Animals; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Kynurenic Acid; Male; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermine | 1993 |
Regionally distinct N-methyl-D-aspartate receptors distinguished by quantitative autoradiography of [3H]MK-801 binding in rat brain.
Topics: Animals; Autoradiography; Brain; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Kinetics; Kynurenic Acid; Male; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tissue Distribution; Tritium | 1993 |
Desensitization of the NMDA receptor complex by glycinergic ligands in cerebellar granule cell cultures.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Amino Acids, Cyclic; Analysis of Variance; Animals; Base Sequence; Blotting, Northern; Cells, Cultured; Cerebellum; Dizocilpine Maleate; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Glycine; Kinetics; Kynurenic Acid; Molecular Sequence Data; Neurons; Neurotoxins; Oligodeoxyribonucleotides; Polymerase Chain Reaction; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Strychnine; Time Factors | 1993 |
Inhibition of [3H]-(+)-MK 801 binding to rat brain sections by CPP and 7-chlorokynurenic acid: an autoradiographic analysis.
Topics: Animals; Autoradiography; Brain; Cerebellum; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Image Processing, Computer-Assisted; In Vitro Techniques; Kynurenic Acid; Male; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1993 |
Whole cell and single channel analysis of the kinetics of glycine-sensitive N-methyl-D-aspartate receptor desensitization.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Cells, Cultured; Female; Glycine; Kinetics; Kynurenic Acid; N-Methylaspartate; Neurons; Pregnancy; Rats; Receptors, N-Methyl-D-Aspartate; Superior Colliculi; Synapses | 1993 |
Adaptive changes in the N-methyl-D-aspartate receptor complex after chronic treatment with imipramine and 1-aminocyclopropanecarboxylic acid.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Amino Acids, Cyclic; Animals; Brain; Dizocilpine Maleate; Drug Administration Schedule; Glycine; Imipramine; In Vitro Techniques; Kynurenic Acid; Male; Mice; Receptors, N-Methyl-D-Aspartate | 1993 |
Pharmacological isolation and characterization of NMDA receptor-mediated synaptic potential in the dentate gyrus of rat hippocampal slices.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Evoked Potentials; Glycine; Hippocampus; In Vitro Techniques; Kynurenic Acid; Magnesium; Male; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synapses | 1993 |
Effects of 5,7 dichlorokynurenic acid on conflict, social interaction and plus maze behaviors.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Behavior, Animal; Conflict, Psychological; Diazepam; Discrimination Learning; Dizocilpine Maleate; Glycine; Kynurenic Acid; Male; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Social Behavior | 1993 |
Allosteric modulation of [3H]CGP 39653 binding by glycine in rat brain.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding, Competitive; Brain; Glycine; Kinetics; Kynurenic Acid; Male; Piperazines; Rats; Rats, Sprague-Dawley; Tritium | 1993 |
Diazepam potentiation by glycine in pentylenetetrazol seizures is antagonized by 7-chlorokynurenic acid.
Topics: Animals; Diazepam; Drug Synergism; Glycine; Injections, Intraventricular; Kynurenic Acid; Male; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Seizures; Strychnine | 1994 |
Adaptation of the N-methyl-D-aspartate receptor complex following chronic antidepressant treatments.
Topics: Adaptation, Physiological; Animals; Antidepressive Agents; Citalopram; Dose-Response Relationship, Drug; Electroshock; Glycine; Imipramine; Kynurenic Acid; Male; Mice; Receptors, N-Methyl-D-Aspartate; Sensitivity and Specificity; Strychnine; Time Factors; Tritium | 1994 |
Potentiation of N-methyl-D-aspartate-evoked elevation of intracellular Ca2+ concentrations by exogenous glycine in cerebellar granule cells.
Topics: Animals; Calcium; Calcium Channel Agonists; Cells, Cultured; Cerebellum; Dizocilpine Maleate; Glycine; Kynurenic Acid; Nicotinic Acids; Oxadiazoles; Rats; Receptors, N-Methyl-D-Aspartate | 1994 |
Diverse modulation by systemic lidocaine of iontophoretic NMDA and quisqualic acid induced excitations on rat dorsal horn neurons.
Topics: Animals; Drug Synergism; Glycine; Injections, Intravenous; Iontophoresis; Kynurenic Acid; Lidocaine; Male; N-Methylaspartate; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Strychnine | 1993 |
Connections between the pontine reticular formation and rostral ventrolateral medulla.
Topics: Animals; Blood Pressure; Cobalt; Excitatory Amino Acid Antagonists; Glycine; Heart Rate; Kidney; Kynurenic Acid; Male; Medulla Oblongata; Microinjections; Nerve Block; Neural Pathways; Pons; Rats; Rats, Wistar; Reticular Formation; Sympathetic Nervous System; Synapses | 1993 |
Ca2+ antagonists effect an antidepressant-like adaptation of the NMDA receptor complex.
Topics: Animals; Antidepressive Agents; Binding Sites; Calcium Channel Blockers; Cerebral Cortex; Depression; Diltiazem; Glycine; Kynurenic Acid; Male; Mice; Nimodipine; Receptors, N-Methyl-D-Aspartate | 1993 |
Differential profiles of binding of a radiolabeled agonist and antagonist at a glycine recognition domain on the N-methyl-D-aspartate receptor ionophore complex in rat brain.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Glycine; Kinetics; Kynurenic Acid; Male; Piperidines; Radioligand Assay; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synaptic Membranes; Tritium | 1994 |
Excitatory amino acid receptor antagonists and naloxone-precipitated withdrawal syndrome in morphine-dependent mice.
Topics: Animals; Behavior, Animal; Dizocilpine Maleate; Glycine; Kynurenic Acid; Male; Mice; Morphine Dependence; Naloxone; Quinoxalines; Receptors, Amino Acid; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Substance Withdrawal Syndrome | 1993 |
Support for radiolabeling of a glycine recognition domain on the N-methyl-D-aspartate receptor ionophore complex by 5,7-[3H]dichlorokynurenate in rat brain.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Glycine; Kinetics; Kynurenic Acid; Male; Radioligand Assay; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Substrate Specificity; Synaptic Membranes; Tritium | 1993 |
A glycine antagonist 7-chlorokynurenic acid attenuates ischemia-induced learning deficits.
Topics: Analysis of Variance; Animals; Cerebral Ventricles; Discrimination, Psychological; Glycine; Hippocampus; Injections, Intraventricular; Ischemic Attack, Transient; Kynurenic Acid; Learning; Learning Disabilities; Male; Prosencephalon; Pyramidal Tracts; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1993 |
Antidepressant-like actions of the polyamine site NMDA antagonist, eliprodil (SL-82.0715).
Topics: Adrenergic beta-Antagonists; Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Behavior, Animal; Biogenic Polyamines; Brain Chemistry; Down-Regulation; Excitatory Amino Acid Antagonists; Glycine; Imipramine; Kynurenic Acid; Male; Mice; Mice, Inbred C57BL; Motor Activity; Piperidines; Receptors, Glycine | 1995 |
The glycine binding site of the N-methyl-D-aspartate receptor subunit NR1: identification of novel determinants of co-agonist potentiation in the extracellular M3-M4 loop region.
Topics: Amino Acid Sequence; Bacterial Proteins; Binding Sites; Carrier Proteins; Epitopes; Excitatory Amino Acid Antagonists; Glycine; Kynurenic Acid; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligopeptides; Protein Conformation; Receptors, N-Methyl-D-Aspartate | 1996 |
Human brain N-methyl-D-aspartate receptors regulating noradrenaline release are positively modulated by HIV-1 coat protein gp120.
Topics: Adult; Aged; Allosteric Site; Cerebral Cortex; Excitatory Amino Acid Antagonists; Female; Gene Products, env; Glycine; HIV Envelope Protein gp120; HIV-1; Humans; Kynurenic Acid; Male; Middle Aged; N-Methylaspartate; Norepinephrine; Peptide Fragments; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Synaptosomes | 1996 |
Synthesis and structure-activity relationships of 1,2,3,4-tetrahydroquinoline-2,3,4-trione 3-oximes: novel and highly potent antagonists for NMDA receptor glycine site.
Topics: Animals; Brain; Cell Membrane; Cerebral Cortex; Cloning, Molecular; Excitatory Amino Acid Antagonists; Female; Glycine; Kinetics; Kynurenic Acid; Magnetic Resonance Spectroscopy; Molecular Structure; Oocytes; Oximes; Quinolines; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Structure-Activity Relationship; Xenopus | 1996 |
Behavioral effects mediated by the modulatory glycine site of the NMDA receptor in the anterodorsal striatum and nucleus accumbens.
Topics: Animals; Corpus Striatum; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glycine; Kynurenic Acid; Locomotion; Male; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1996 |
Use of subunit-specific antisense oligodeoxynucleotides to define developmental changes in the properties of N-methyl-D-aspartate receptors.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Animals, Newborn; Base Sequence; Cerebral Cortex; Excitatory Amino Acid Antagonists; Female; Gene Expression Regulation, Developmental; Glycine; Kynurenic Acid; Macromolecular Substances; Molecular Sequence Data; N-Methylaspartate; Oligonucleotides, Antisense; Oocytes; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Xenopus laevis | 1996 |
Effect of 1-aminocyclopropanecarboxylic acid on N-methyl-D-aspartate-stimulated [3H]-noradrenaline release in rat hippocampal synaptosomes.
Topics: Adrenergic alpha-Antagonists; Animals; Cyclopropanes; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; Kynurenic Acid; Male; N-Methylaspartate; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptosomes; Tritium | 1996 |
Excitoprotective effect of felbamate in cultured cortical neurons.
Topics: Animals; Anticonvulsants; Binding Sites; Calcium; Cell Death; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Felbamate; Glycine; Kainic Acid; Kynurenic Acid; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxins; Phenylcarbamates; Propylene Glycols; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Strychnine | 1995 |
High level expression of the NMDAR1 glutamate receptor subunit in electroporated COS cells.
Topics: Animals; beta-Galactosidase; Binding, Competitive; Calcium; Cell Line; Chlorocebus aethiops; COS Cells; Electroporation; Excitatory Amino Acid Antagonists; Glycine; Humans; Kidney; Kinetics; Kynurenic Acid; Macromolecular Substances; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Fusion Proteins; Serine; Stereoisomerism; Transfection | 1996 |
[3H]MDL 105,519, a high-affinity radioligand for the N-methyl-D-aspartate receptor-associated glycine recognition site.
Topics: Animals; Binding Sites; Glycine; Hydrogen-Ion Concentration; Indoles; Kynurenic Acid; Ligands; Rats; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 1996 |
Glycine and calcium-dependent effects of lead on N-methyl-D-aspartate receptor function in rat hippocampal neurons.
Topics: Animals; Binding Sites; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Glycine; Hippocampus; Kynurenic Acid; Lead; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1996 |
Differential effects of five glycine site antagonists on NMDA receptor desensitisation.
Topics: Animals; Benzothiadiazines; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glycine; Kynurenic Acid; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Quinolones; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1996 |
Reduction in the mechanonociceptive response by intrathecal administration of glycine and related compounds.
Topics: Animals; Cerebrospinal Fluid; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glycine; Glycine Agents; Injections, Spinal; Kynurenic Acid; Male; Mechanoreceptors; Neuralgia; Nociceptors; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Strychnine; Transcutaneous Electric Nerve Stimulation | 1996 |
Spontaneous motoneuronal activity mediated by glycine and GABA in the spinal cord of rat fetuses in vitro.
Topics: Animals; Calcium; Electrophysiology; Evoked Potentials; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glycine; Kynurenic Acid; Rats; Rats, Wistar; Receptors, GABA; Receptors, Glycine; Spinal Cord; Strychnine; Tetrodotoxin | 1996 |
Postsynaptic glutamate uptake in rat cerebellar Purkinje cells.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Benzoates; Cycloleucine; Electrophysiology; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Ion Channel Gating; Kynurenic Acid; Membrane Potentials; Monosaccharide Transport Proteins; Neuroprotective Agents; Purkinje Cells; Rats; Receptors, Metabotropic Glutamate; Synaptic Transmission; Tetrodotoxin | 1996 |
Structure-activity relationships of alkyl- and alkoxy-substituted 1,4-dihydroquinoxaline-2,3-diones: potent and systemically active antagonists for the glycine site of the NMDA receptor.
Topics: Animals; Anticonvulsants; Binding Sites; Binding, Competitive; Cerebral Cortex; Electrophysiology; Excitatory Amino Acid Antagonists; Glycine; Kynurenic Acid; Magnetic Resonance Spectroscopy; Mice; Molecular Structure; Oocytes; Quinoxalines; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Structure-Activity Relationship; Xenopus | 1997 |
Partition of transient and sustained inhibitory glycinergic input to retinal ganglion cells.
Topics: Alanine; Ambystoma; Animals; Electrophysiology; Excitatory Amino Acid Antagonists; Glycine; Glycine Agents; Kynurenic Acid; Receptors, Glycine; Retinal Ganglion Cells; Serine; Strychnine; Synaptic Transmission; Taurine | 1997 |
Neurotoxicity associated with dual actions of homocysteine at the N-methyl-D-aspartate receptor.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adult; Animals; Cells, Cultured; Cerebral Cortex; Child; Dizocilpine Maleate; Embryo, Mammalian; Evoked Potentials; Glycine; Homocysteine; Humans; Kinetics; Kynurenic Acid; N-Methylaspartate; Neurons; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1997 |
Characterization of 5,7-dichlorokynurenate-insensitive D-[3H]serine binding to synaptosomal fraction isolated from rat brain tissues.
Topics: Animals; Binding Sites; Binding, Competitive; Brain Chemistry; Cations; Cerebellum; Cerebral Cortex; Detergents; Excitatory Amino Acid Antagonists; Glycine; Kidney; Kynurenic Acid; Liver; Male; Octoxynol; Rats; Rats, Wistar; Serine; Subcellular Fractions; Synaptosomes; Tritium | 1997 |
A partial agonist model used in the allosteric modulation of the NMDA receptor.
Topics: 2-Amino-5-phosphonovalerate; Allosteric Regulation; Animals; Cerebellum; Cerebral Cortex; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; In Vitro Techniques; Kynurenic Acid; Male; Models, Biological; Protein Binding; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1997 |
Electrically-evoked dopamine and acetylcholine release from rat striatal slices perfused without magnesium: regulation by glutamate acting on NMDA receptors.
Topics: Acetylcholine; Animals; Corpus Striatum; Dopamine; Electric Stimulation; Glutamic Acid; Glycine; In Vitro Techniques; Kynurenic Acid; Magnesium; Male; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1997 |
NMDA receptor coagonist glycine site: evidence for a role in lateral hypothalamic stimulation of feeding.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Eating; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Hypothalamic Area, Lateral; Kainic Acid; Kynurenic Acid; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1997 |
Gp120 can revert antagonism at the glycine site of NMDA receptors mediating GABA release from cultured hippocampal neurons.
Topics: Animals; Binding Sites; Cells, Cultured; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fetus; gamma-Aminobutyric Acid; Glycine; Hippocampus; HIV Envelope Protein gp120; HIV-1; Kynurenic Acid; N-Methylaspartate; Neurons; Rats; Receptors, N-Methyl-D-Aspartate; Tritium | 1997 |
Neurotrophin modulation of NMDA receptors in cultured murine and isolated rat neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain-Derived Neurotrophic Factor; Calcium; Cells, Cultured; Corpus Striatum; Dynorphins; Embryo, Mammalian; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; Ion Channel Gating; Kynurenic Acid; Magnesium; Membrane Potentials; Mice; N-Methylaspartate; Nerve Growth Factors; Neurons; Neurotrophin 3; Protein Kinase Inhibitors; Pyramidal Cells; Rats; Rats, Wistar; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 1997 |
GV 150526A, 7-Cl-kynurenic acid and HA 966 antagonize the glycine enhancement of N-methyl-D-aspartate-induced [3H]noradrenaline and [3H]dopamine release.
Topics: Animals; Dopamine; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; Indoles; Kynurenic Acid; Male; N-Methylaspartate; Neostriatum; Norepinephrine; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Synaptosomes | 1997 |
Modulation of neuronal mitochondrial membrane potential by the NMDA receptor: role of arachidonic acid.
Topics: 2-Amino-5-phosphonovalerate; Anesthetics, Local; Animals; Arachidonic Acid; Biomarkers; Cells, Cultured; Cerebellum; Dibucaine; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Flow Cytometry; Fluorescent Dyes; Glycine; Intracellular Membranes; Kynurenic Acid; Membrane Potentials; Mitochondria; N-Methylaspartate; Piperidines; Quinacrine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Rhodamine 123; Rhodamines; Sulfonamides | 1997 |
2,3-Dihydro-6,7-dichloro-pyrido[2,3-b]pyrazine-8-oxide as selective glycine antagonist with in vivo activity.
Topics: Animals; Avoidance Learning; Binding Sites; Cyclic N-Oxides; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glycine; Kynurenic Acid; Mice; Motor Activity; N-Methylaspartate; Neuroprotective Agents; Pyrazines; Rats; Receptors, N-Methyl-D-Aspartate; Seizures; Stereotyped Behavior; Strychnine | 1997 |
Glycine increases arterial pressure and augments NMDA-induced pressor responses in the dorsomedial and ventrolateral medulla of cats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Blood Pressure; Cats; Dorsomedial Hypothalamic Nucleus; Drug Synergism; Excitatory Amino Acid Antagonists; Female; Glutamates; Glutamic Acid; Glycine; Kynurenic Acid; Male; Microinjections; N-Methylaspartate; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Ventromedial Hypothalamic Nucleus | 1997 |
Functional characterization of human N-methyl-D-aspartate subtype 1A/2D receptors.
Topics: Animals; Calcium; Cells, Cultured; DNA, Complementary; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fetus; Glutamic Acid; Glycine; Humans; Kidney; Kynurenic Acid; Membrane Potentials; Molecular Sequence Data; N-Methylaspartate; Oocytes; Patch-Clamp Techniques; Pipecolic Acids; Piperidines; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Sequence Homology, Amino Acid; Serine; Xenopus laevis | 1998 |
Protein kinases modulate two glycine currents in salamander retinal ganglion cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Ambystoma; Animals; Colforsin; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glycine; Glycine Agents; Isoquinolines; Kinetics; Kynurenic Acid; Membrane Potentials; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Protein Kinase C; Retinal Ganglion Cells; Strychnine; Sulfonamides | 1998 |
Expression and initial characterization of a soluble glycine binding domain of the N-methyl-D-aspartate receptor NR1 subunit.
Topics: Animals; Baculoviridae; Binding Sites; Binding, Competitive; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Indoles; Kynurenic Acid; Protein Binding; Protein Conformation; Receptors, N-Methyl-D-Aspartate; Recombinant Fusion Proteins; Serine; Spodoptera | 1998 |
Felbamate increases [3H]glycine binding in rat brain and sections of human postmortem brain.
Topics: Animals; Anticonvulsants; Autoradiography; Brain Chemistry; Excitatory Amino Acid Antagonists; Felbamate; Glycine; Humans; Kynurenic Acid; Male; Phenylcarbamates; Postmortem Changes; Propylene Glycols; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 1998 |
Chronic dosing with 1-aminocyclopropanecarboxylic acid, a glycine partial agonist, modulates NMDA inhibition of muscarinic-coupled PI hydrolysis in rat cortical slices.
Topics: 2-Amino-5-phosphonovalerate; Animals; Carbachol; Cerebral Cortex; Cycloleucine; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Hydrolysis; In Vitro Techniques; Inositol; Kynurenic Acid; Male; Muscarinic Agonists; N-Methylaspartate; Phosphatidylinositols; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1998 |
Complex polyamine effects on [3H]MDL 105,519 binding to the NMDA receptor glycine site.
Topics: Aminoquinolines; Animals; Binding Sites; Binding, Competitive; Brain; Cell Membrane; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glycine; Indoles; Kynurenic Acid; Polyamines; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine; Tritium | 1998 |
Glutamate in the nucleus of the solitary tract activates both ionotropic and metabotropic glutamate receptors.
Topics: Animals; Benzoates; Blood Pressure; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Heart Rate; Kynurenic Acid; Lumbosacral Region; Male; Microinjections; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Solitary Nucleus; Sympathetic Nervous System | 1998 |
Sympathoexcitatory neurotransmission of the chemoreflex in the NTS of awake rats.
Topics: Animals; Benzoates; Cardiovascular Physiological Phenomena; Chemoreceptor Cells; Excitatory Amino Acid Antagonists; Glycine; Kynurenic Acid; Male; Microinjections; Quinoxalines; Rats; Rats, Wistar; Reflex; Solitary Nucleus; Sympathetic Nervous System; Synaptic Transmission | 1999 |
Mechanisms involved in the metabotropic glutamate receptor-enhancement of NMDA-mediated motoneurone responses in frog spinal cord.
Topics: Amino Acids, Dicarboxylic; Aminobutyrates; Animals; Benzoates; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Chlorpromazine; Cycloleucine; Dose-Response Relationship, Drug; Drug Synergism; Egtazic Acid; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; GTP-Binding Proteins; In Vitro Techniques; Kynurenic Acid; Magnesium; Membrane Potentials; Motor Neurons; N-Methylaspartate; Neuroprotective Agents; Pertussis Toxin; Rana pipiens; Receptors, Metabotropic Glutamate; Reflex; Resorcinols; Second Messenger Systems; Spinal Cord; Sulfonamides; Tetrodotoxin; Thapsigargin; Virulence Factors, Bordetella | 1999 |
Glycine antagonist and NO synthase inhibitor protect the developing mouse brain against neonatal excitotoxic lesions.
Topics: Animals; Animals, Newborn; Brain; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Humans; Kynurenic Acid; Mice; Nitric Oxide Synthase; Nitroarginine | 1999 |
Properties of NMDA receptors in rat spinal cord motoneurons.
Topics: 2-Amino-5-phosphonovalerate; Age Factors; Animals; Animals, Newborn; Electric Conductivity; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Glycine; Ion Channel Gating; Kainic Acid; Kynurenic Acid; Magnesium; Male; Motor Neurons; N-Methylaspartate; Organ Culture Techniques; Patch-Clamp Techniques; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1999 |
Ferrous iron modulates quinolinate-mediated [3H]MK-801 binding to rat brain synaptic membranes in the presence of glycine and spermidine.
Topics: 2-Amino-5-phosphonovalerate; Allosteric Regulation; Animals; Binding Sites; Brain; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Ferrous Compounds; Glutamic Acid; Glycine; Inhibitory Concentration 50; Kynurenic Acid; Male; Quinolinic Acid; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermidine; Synaptic Membranes | 1999 |
Rapid, experience-dependent expression of synaptic NMDA receptors in visual cortex in vivo.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Animals, Suckling; Bicuculline; Cycloheximide; Darkness; Electric Stimulation; Excitatory Amino Acid Antagonists; Female; Gene Expression Regulation, Developmental; Glycine; Kynurenic Acid; Light; Male; Models, Neurological; Nerve Tissue Proteins; Neuronal Plasticity; Optic Nerve; Photic Stimulation; Piperidines; Protein Synthesis Inhibitors; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Sensory Deprivation; Synapses; Vision, Ocular; Visual Cortex; Zinc | 1999 |
Role of glutamate receptor subtypes in the lamprey respiratory network.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Benzoates; Excitatory Amino Acid Antagonists; Glycine; Kainic Acid; Kynurenic Acid; Lampreys; Neurons; Receptors, AMPA; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Respiration | 1999 |
Cardiovascular response to group I metabotropic glutamate receptor activation in NTS.
Topics: Animals; Baroreflex; Benzoates; Blood Pressure; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Kainic Acid; Kynurenic Acid; Male; Methoxyhydroxyphenylglycol; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Sympathetic Nervous System | 1999 |
Na+, K+ and Ca2+ antagonize the glutamate- and glycine-induced decrease of [3H]MK-801 binding observed in the presence of Mg2+ at low pH.
Topics: Animals; Calcium; Cations; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamates; Glycine; Hydrogen-Ion Concentration; Kynurenic Acid; Magnesium; Male; Potassium; Protein Binding; Quinolones; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sodium | 1999 |
In vivo recording from identifiable neurons of the locomotor network in the developing zebrafish.
Topics: Action Potentials; Animals; Bicuculline; Embryo, Nonmammalian; Excitatory Amino Acid Antagonists; GABA Antagonists; Glycine; Kynurenic Acid; Motor Neurons; Patch-Clamp Techniques; Periodicity; Rhodamines; Rhombencephalon; Spinal Cord; Swimming; Tetrodotoxin; Zebrafish | 1999 |
Rostral ventrolateral medulla : A source of sympathetic activation in rats subjected to long-term treatment with L-NAME.
Topics: Animals; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Hypertension; Kynurenic Acid; Male; Medulla Oblongata; NG-Nitroarginine Methyl Ester; Rats; Rats, Wistar; Sympathetic Nervous System | 1999 |
Quantitative differences in the effects of de novo produced and exogenous kynurenic acid in rat brain slices.
Topics: Animals; Buffers; Entorhinal Cortex; Epilepsy; Evoked Potentials; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; Kynurenic Acid; Magnesium; Male; Neurotransmitter Agents; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Tryptophan | 1999 |
A mutation in the glycine binding pocket of the N-methyl-D-aspartate receptor NR1 subunit alters agonist efficacy.
Topics: Animals; Binding Sites; Binding, Competitive; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glycine; Kynurenic Acid; Mice; Mutation; Oocytes; Pyrrolidinones; Receptors, N-Methyl-D-Aspartate; Xenopus laevis | 1999 |
Regulation by glycine, Mg2+ and polyamines of the N-methyl-D-aspartate-induced locomotion in the neonatal rat spinal cord in vitro.
Topics: Animals; Biguanides; Excitatory Amino Acid Antagonists; Glycine; In Vitro Techniques; Kynurenic Acid; Magnesium; Motor Activity; Motor Neurons; N-Methylaspartate; Polyamines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermine; Spinal Cord; Synapses | 1999 |
Glutamate-induced rise in cytosolic calcium concentration stimulates in vitro rates of juvenile hormone biosynthesis in corpus allatum of Diploptera punctata.
Topics: Animals; Calcium; Cockroaches; Corpora Allata; Cytosol; Data Interpretation, Statistical; Dopamine; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Glycine; In Vitro Techniques; Juvenile Hormones; Kynurenic Acid; Magnesium | 1999 |
Specific glutathione binding sites in pig cerebral cortical synaptic membranes.
Topics: Animals; Binding Sites; Cerebral Cortex; Cysteine; Dipeptides; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glutathione; Glycine; Kynurenic Acid; Ligands; Neurons; Radioligand Assay; Receptors, GABA; Receptors, Glutamate; Receptors, Peptide; Signal Transduction; Swine; Synaptic Membranes; Tritium | 2000 |
Glycine induced calcium concentration changes in vestibular type I sensory cells.
Topics: Animals; Calcium; Chelating Agents; Chlorides; Egtazic Acid; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamates; Glycine; Guinea Pigs; Hair Cells, Vestibular; Kynurenic Acid; Models, Neurological; N-Methylaspartate; Strychnine | 2000 |
Noradrenergic lesion antagonizes desipramine-induced adaptation of NMDA receptors.
Topics: Adaptation, Physiological; Animals; Antidepressive Agents, Tricyclic; Benzylamines; Cerebral Cortex; Desipramine; Fluoxetine; Glycine; Kynurenic Acid; Male; Mice; Norepinephrine; Receptors, N-Methyl-D-Aspartate | 2000 |
Long-term potentiation of primary afferent neurotransmission at trigeminal synapses of juvenile rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Benzoates; Chelating Agents; Egtazic Acid; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; In Vitro Techniques; Kynurenic Acid; Long-Term Potentiation; Neurons, Afferent; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission; Trigeminal Nuclei | 2000 |
Enhancement of NMDA-induced current by the putative NR2B selective antagonist ifenprodil.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Kynurenic Acid; Male; Membrane Potentials; N-Methylaspartate; Organ Culture Techniques; Piperidines; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermine | 2000 |
Chronic glycine treatment desensitizes the behavioral response to 1-aminocyclopropanecarboxylic acid (ACPC), a partial agonist at the strychnine-insensitive glycine site of the NMDA receptor complex.
Topics: Amino Acids; Amino Acids, Cyclic; Animals; Behavior, Animal; Binding Sites; Cerebral Cortex; Glycine; Hippocampus; Kynurenic Acid; Male; Mice; Psychomotor Performance; Radioligand Assay; Receptors, N-Methyl-D-Aspartate; Strychnine; Tritium | 2000 |
Modification of the Xenopus electroretinogram by actions of glycine in the proximal retina.
Topics: Aminobutyrates; Animals; Dose-Response Relationship, Drug; Electroretinography; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Glycine Agents; In Vitro Techniques; Kynurenic Acid; N-Methylaspartate; Photic Stimulation; Pipecolic Acids; Retina; Strychnine; Xenopus laevis | 2000 |
Proconvulsive effects of the mitochondrial respiratory chain inhibitor--3-nitropropionic acid.
Topics: Acetylcholine; Animals; Convulsants; Drug Interactions; Electric Stimulation; Electron Transport; Electroshock; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glycine; Kynurenic Acid; Male; Mice; Nitro Compounds; Potassium Channels; Propionates; Seizures; Synaptic Transmission | 2000 |
Chronic treatment with antidepressants affects glycine/NMDA receptor function: behavioral evidence.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Behavior, Animal; Chlordiazepoxide; Dose-Response Relationship, Drug; Electroshock; Excitatory Amino Acid Antagonists; Glycine; Kynurenic Acid; Male; Mice; Quinolones; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 2000 |
A novel series of 2-carboxytetrahydroquinolines provides new insights into the eastern region of glycine site NMDA antagonists.
Topics: Animals; Binding Sites; Brain; Cell Membrane; Ethers, Cyclic; Excitatory Amino Acid Antagonists; Glycine; Kynurenic Acid; Male; Patch-Clamp Techniques; Quinolines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Urea | 2000 |
Some metabotropic glutamate receptor ligands reduce kynurenate synthesis in rats by intracellular inhibition of kynurenine aminotransferase II.
Topics: Aminobutyrates; Animals; Aspartic Acid; Calcium; Cerebral Cortex; Corpus Striatum; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glycine; In Vitro Techniques; Intracellular Fluid; Kynurenic Acid; Ligands; Liver; Lyases; Male; Microdialysis; Microinjections; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Sodium; Transaminases | 2000 |
Effect of extracellular long-time microperfusion of high concentrations of glutamate and glycine on picrotoxin seizure thresholds in the hippocampus of freely moving rats.
Topics: Animals; Epilepsy; Excitatory Amino Acid Antagonists; Extracellular Space; GABA Antagonists; Glutamic Acid; Glycine; Hippocampus; Kynurenic Acid; Male; Microdialysis; Motor Activity; Neural Inhibition; Picrotoxin; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Seizures | 2001 |
Effect of the glycine modulatory site of the N-methyl-D-aspartate receptor on synaptic responses in kitten visual cortex.
Topics: Animals; Binding Sites; Cats; Electric Stimulation; Excitatory Amino Acid Antagonists; Female; Glycine; Kynurenic Acid; Long-Term Potentiation; Male; Membrane Potentials; Neurons; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Serine; Synapses; Synaptic Transmission; Visual Cortex | 2001 |
Developmental changes in 5-hydroxytryptamine-induced rhythmic activity in the spinal cord of rat fetuses in vitro.
Topics: Animals; Excitatory Amino Acid Antagonists; Fetus; GABA Antagonists; Glutamic Acid; Glycine; Glycine Agents; Kynurenic Acid; Locomotion; Nerve Net; Periodicity; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, Glycine; Serotonin; Spinal Cord; Strychnine; Synaptic Transmission | 2001 |
The brain metabolite kynurenic acid inhibits alpha7 nicotinic receptor activity and increases non-alpha7 nicotinic receptor expression: physiopathological implications.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Binding, Competitive; Brain; Cells, Cultured; Choline; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Administration Schedule; Electrophysiology; Glycine; Hippocampus; In Vitro Techniques; Kynurenic Acid; Male; N-Methylaspartate; Neurons; Nicotine; Nicotinic Agonists; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptor Cross-Talk; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic | 2001 |
Ethanol inhibition of N-methyl-D-aspartate receptors is reduced by site-directed mutagenesis of a transmembrane domain phenylalanine residue.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Cell Line; Dose-Response Relationship, Drug; Ethanol; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Humans; Kynurenic Acid; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Patch-Clamp Techniques; Phenylalanine; Protein Binding; Protein Structure, Tertiary; Pyrrolidinones; Receptors, N-Methyl-D-Aspartate; Sequence Homology, Amino Acid; Transfection; Xenopus laevis | 2001 |
Glycine receptor-mediated inhibition of dopamine and non-dopamine neurons of the rat ventral tegmental area in vitro.
Topics: Action Potentials; Animals; Dopamine; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; Glycine Agents; Kynurenic Acid; Male; Neural Inhibition; Neurons; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Strychnine; Synaptic Transmission; Tetrodotoxin; Ventral Tegmental Area | 2001 |
Vasodilatory N-methyl-D-aspartate receptors are constitutively expressed in rat kidney.
Topics: Analysis of Variance; Animals; Dizocilpine Maleate; DNA, Complementary; Glomerular Filtration Rate; Glycine; Hemodynamics; Immunohistochemistry; Kidney Cortex; Kynurenic Acid; Male; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Renal Circulation; Reverse Transcriptase Polymerase Chain Reaction | 2002 |
Role of L-glutamate in systemic AVP-induced hypothermia.
Topics: Adipose Tissue, Brown; Animals; Arginine Vasopressin; Blood Pressure; Body Temperature; Body Temperature Regulation; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Heart Rate; Hypothermia; Injections, Intravenous; Injections, Intraventricular; Kynurenic Acid; Male; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Tail; Thermogenesis | 2003 |
Nicotinic receptors regulate the release of glycine onto lamina X neurones of the rat spinal cord.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aconitine; Alkaloids; Anesthetics, Local; Animals; Animals, Newborn; Azocines; Bicuculline; Dihydro-beta-Erythroidine; Dimethylphenylpiperazinium Iodide; Drug Interactions; Excitatory Amino Acid Antagonists; Glycine; Glycine Agents; Hexamethonium; In Vitro Techniques; Kynurenic Acid; Membrane Potentials; Neurons; Nicotinic Agonists; Nicotinic Antagonists; Patch-Clamp Techniques; Quinolizines; Rats; Rats, Wistar; Receptors, Nicotinic; Spinal Cord; Strychnine; Tetrodotoxin; Time Factors; Tubocurarine | 2002 |
Evidence against the presence of NMDA receptors at a central glutamatergic synapse in leeches.
Topics: 2-Amino-5-phosphonovalerate; Animals; Association Learning; Central Nervous System; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Kynurenic Acid; Leeches; Motor Neurons; N-Methylaspartate; Neurons, Afferent; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Reflex; Synapses; Synaptic Transmission | 2002 |
Kynurenate production by cultured human astrocytes.
Topics: Aminooxyacetic Acid; Astrocytes; Brain; Cells, Cultured; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Fluorescent Antibody Technique; Glycine; Humans; Immunohistochemistry; Kynurenic Acid; Kynurenine; Leucine; Neuroprotective Agents; Nicotine; Oxaloacetic Acid; Phenylalanine; Pyruvic Acid; Receptors, Nicotinic; Transaminases | 2003 |
Synthesis and SAR of novel di- and trisubstituted 1,4-dihydroquinoxaline-2,3-diones related to licostinel (Acea 1021) as NMDA/glycine site antagonists.
Topics: Animals; Binding Sites; Cell Membrane; Cerebral Cortex; Glycine; Inhibitory Concentration 50; Kynurenic Acid; Quinoxalines; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 2003 |
Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core.
Topics: Amino Acid Sequence; Animals; Binding Sites; Crystallography, X-Ray; Disulfides; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Kynurenic Acid; Models, Molecular; Molecular Sequence Data; Molecular Structure; Protein Binding; Protein Conformation; Protein Subunits; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Sequence Alignment; Serine | 2003 |
Potentiation of N-methyl-D-aspartate-induced currents by the nootropic drug nefiracetam in rat cortical neurons.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Electrophysiology; Female; Glycine; Kynurenic Acid; N-Methylaspartate; Neurons; Nootropic Agents; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate | 2003 |
Role of endogenous angiotensin II on glutamatergic actions in the rostral ventrolateral medulla in Goldblatt hypertensive rats.
Topics: Angiotensin II; Animals; Blood Pressure; Captopril; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Hypertension, Renovascular; Kynurenic Acid; Male; Medulla Oblongata; Microinjections; Rats; Rats, Wistar | 2003 |
Selective antagonism of rat inhibitory glycine receptor subunits.
Topics: Animals; Arginine; Cell Line; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glycine; Glycine Agents; Humans; Kynurenic Acid; Mutation; Osmolar Concentration; Rats; Receptors, Glycine; Strychnine | 2004 |
Active release of glycine or D-serine saturates the glycine site of NMDA receptors at the cerebellar mossy fibre to granule cell synapse.
Topics: Animals; Animals, Newborn; Binding, Competitive; Cerebellum; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; In Vitro Techniques; Kynurenic Acid; Models, Biological; Nerve Fibers; Neurons; Patch-Clamp Techniques; Rats; Receptors, N-Methyl-D-Aspartate; Serine | 2003 |
Model structures of the N-methyl-D-aspartate receptor subunit NR1 explain the molecular recognition of agonist and antagonist ligands.
Topics: Alanine; Amino Acid Sequence; Animals; Bacterial Proteins; Binding Sites; Crystallography, X-Ray; Cycloserine; Databases as Topic; Escherichia coli; Excitatory Amino Acid Antagonists; Glycine; Humans; Hydrogen Bonding; Indoles; Kynurenic Acid; Ligands; Mice; Models, Chemical; Models, Molecular; Molecular Sequence Data; Potassium Channels; Proline; Protein Binding; Protein Conformation; Protein Isoforms; Protein Structure, Tertiary; Rats; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Sequence Homology, Amino Acid; Serine; Threonine; Tryptophan; Water | 2004 |
Glutamate release increases during mossy-CA3 LTP but not during Schaffer-CA1 LTP.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Aspartic Acid; Calcium; Colforsin; Coloring Agents; Cyclopropanes; Dose-Response Relationship, Radiation; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Glycine; Hippocampus; In Vitro Techniques; Kynurenic Acid; Long-Term Potentiation; Magnesium; Male; Mossy Fibers, Hippocampal; Neuroglia; Rats; Rats, Sprague-Dawley; Time Factors | 2004 |
Glutamatergic neurotransmission modulates hypoxia-induced hyperventilation but not anapyrexia.
Topics: Animals; Benzoates; Body Temperature; Body Temperature Regulation; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Hyperventilation; Hypoxia; Injections, Intraventricular; Kynurenic Acid; Male; Rats; Rats, Wistar | 2004 |
Glycine-induced neurotoxicity in organotypic hippocampal slice cultures.
Topics: Alanine; Animals; Animals, Newborn; Brain Ischemia; Dose-Response Relationship, Drug; Drug Resistance; Glutamic Acid; Glycine; Hippocampus; Kynurenic Acid; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Strychnine; Taurine | 2005 |
Putative NMDA receptors in Hydra: a biochemical and functional study.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Binding Sites; Cell Membrane; Concanavalin A; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Feeding Behavior; Glutamic Acid; Glutathione; Glycine; Hydra; Kynurenic Acid; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Serine; Strychnine | 2004 |
Structural consequences of D481N/K483Q mutation at glycine binding site of NMDA ionotropic glutamate receptors: a molecular dynamics study.
Topics: Amino Acid Sequence; Binding Sites; Computer Simulation; Crystallography, X-Ray; Glycine; Hydrogen Bonding; Kynurenic Acid; Models, Molecular; Molecular Sequence Data; N-Methylaspartate; Point Mutation; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Receptors, N-Methyl-D-Aspartate; Sequence Homology, Amino Acid; Water | 2005 |
Glutamatergic receptors of the rostral ventrolateral medulla are involved in the ventilatory response to hypoxia.
Topics: Animals; Benzoates; Body Temperature; Body Temperature Regulation; Drug Interactions; Excitatory Amino Acid Antagonists; Glycine; Hyperventilation; Hypothermia; Hypoxia; Kynurenic Acid; Male; Medulla Oblongata; Microinjections; Pulmonary Ventilation; Rats; Rats, Wistar; Receptors, Glutamate; Tidal Volume; Time Factors; Ventilators, Mechanical | 2005 |
Role of the glycine site of the N-methyl-D-aspartate receptor in synaptic plasticity induced by pairing.
Topics: Afferent Pathways; Animals; Electric Stimulation; Excitatory Postsynaptic Potentials; Glycine; Hippocampus; Kynurenic Acid; Long-Term Potentiation; Neuronal Plasticity; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Serine; Synapses | 2005 |
Homocysteine, a risk factor for atherosclerosis, biphasically changes the endothelial production of kynurenic acid.
Topics: Animals; Aorta, Thoracic; Arteriosclerosis; Cysteine; Dose-Response Relationship, Drug; Endothelium, Vascular; Excitatory Amino Acid Antagonists; Glycine; Homocysteine; In Vitro Techniques; Injections, Intraperitoneal; Kynurenic Acid; Leucine; Male; Methionine; Phenylalanine; Pipecolic Acids; Rats; Rats, Wistar; Risk Factors; S-Adenosylhomocysteine | 2005 |
Cell-specific expression of N-methyl-D-aspartate receptor subunits in Müller glia and neurons from the chick retina.
Topics: Animals; Blotting, Western; Cells, Cultured; Chick Embryo; Glycine; Isoenzymes; Kynurenic Acid; Neuroglia; Neurons; Radioligand Assay; Receptors, N-Methyl-D-Aspartate; Retina; Reverse Transcriptase Polymerase Chain Reaction; Serine; Spermine; Synaptic Membranes | 2005 |
Chemoreflex sympathoexcitation was not altered by the antagonism of glutamate receptors in the commissural nucleus tractus solitarii in the working heart-brainstem preparation of rats.
Topics: Action Potentials; Adaptation, Physiological; Animals; Brain Stem; Chemoreceptor Cells; Decerebrate State; Drug Combinations; Glycine; Heart; Heart Rate; Kynurenic Acid; Male; Rats; Rats, Wistar; Receptors, Glutamate; Reflex; Solitary Nucleus; Sympathetic Nervous System | 2006 |
Is endogenous D-serine in the rostral anterior cingulate cortex necessary for pain-related negative affect?
Topics: Animals; Anxiety; D-Amino-Acid Oxidase; Excitatory Amino Acid Antagonists; Fear; Glycine; Gyrus Cinguli; Kynurenic Acid; Male; Membrane Potentials; N-Methylaspartate; Organ Culture Techniques; Pain; Pain Measurement; Pain Threshold; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Serine; Stress, Psychological; Synaptic Transmission | 2006 |
Elevated T-maze evaluation of anxiety and memory effects of NMDA/glycine-B site ligands injected into the dorsal periaqueductal gray matter and the superior colliculus of rats.
Topics: Animals; Anxiety; Glycine; Kynurenic Acid; Ligands; Male; Maze Learning; Memory; Microinjections; Periaqueductal Gray; Rats; Rats, Wistar; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Serine; Stereoisomerism; Superior Colliculi | 2006 |
Taurine potentiates presynaptic NMDA receptors in hippocampal Schaffer collateral axons.
Topics: Animals; Axons; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Glycine; Hippocampus; Kynurenic Acid; Male; N-Methylaspartate; Organ Culture Techniques; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Serine; Synaptic Transmission; Taurine | 2006 |
Endogenous activation of nicotinic receptors underlies sympathetic tone generation in neonatal rat spinal cord in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aconitine; Animals; Animals, Newborn; Autonomic Fibers, Preganglionic; Cholinergic Fibers; Dihydro-beta-Erythroidine; Dimethylphenylpiperazinium Iodide; Excitatory Amino Acid Antagonists; GABA-A Receptor Antagonists; Glycine; In Vitro Techniques; Interneurons; Kynurenic Acid; Mecamylamine; Nerve Tissue Proteins; Nicotinic Agonists; Nicotinic Antagonists; Organophosphonates; Phenylalanine; Picrotoxin; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Spinal Cord; Splanchnic Nerves; Sympathetic Fibers, Postganglionic; Synaptic Transmission | 2006 |
Contribution of endogenous glycine site NMDA agonists to excitotoxic retinal damage in vivo.
Topics: Amidohydrolases; Animals; Cell Death; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Kynurenic Acid; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Retinal Diseases; Retinal Ganglion Cells; Serine | 2006 |
Glycine binding sites of presynaptic NMDA receptors may tonically regulate glutamate release in the rat visual cortex.
Topics: Animals; Binding Sites; Binding, Competitive; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Glycine; Kynurenic Acid; Organ Culture Techniques; Presynaptic Terminals; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Visual Cortex | 2007 |
Characterisation of the human NMDA receptor subunit NR3A glycine binding site.
Topics: Animals; Binding, Competitive; Brain; Cell Line, Transformed; Cycloserine; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glycine; Humans; Kynurenic Acid; Models, Molecular; Mutation; Protein Binding; Rats; Receptors, N-Methyl-D-Aspartate; Transfection | 2007 |
Pharmacological characterization of glycine-activated currents in HEK 293 cells expressing N-methyl-D-aspartate NR1 and NR3 subunits.
Topics: Alanine; Animals; Cell Line; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Glycine Plasma Membrane Transport Proteins; Humans; Kynurenic Acid; Membrane Potentials; Mice; Mutation; Patch-Clamp Techniques; Pyrrolidinones; Rats; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Sarcosine; Strychnine; Transfection | 2007 |
Corelease of GABA/glycine in lamina-X of the spinal cord of neonatal rats.
Topics: Acetylcholine; Anesthetics, Local; Animals; Animals, Newborn; Bicuculline; Drug Interactions; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; Glycine Agents; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Kynurenic Acid; Neural Inhibition; Neurons; Patch-Clamp Techniques; Rats; Strychnine; Substantia Gelatinosa; Tetrodotoxin | 2007 |
Modulation of glycine potency in rat recombinant NMDA receptors containing chimeric NR2A/2D subunits expressed in Xenopus laevis oocytes.
Topics: Amino Acid Sequence; Animals; Chimera; Dose-Response Relationship, Drug; Electrophysiology; Excitatory Amino Acid Antagonists; Female; Glycine; Kynurenic Acid; Molecular Sequence Data; Oocytes; Patch-Clamp Techniques; Rats; Receptors, N-Methyl-D-Aspartate; RNA, Complementary; Xenopus laevis | 2008 |
Glycinergic synaptic currents in the deep cerebellar nuclei.
Topics: Age Factors; Animals; Animals, Newborn; Bicuculline; Cerebellar Nuclei; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; GABA Antagonists; Glycine; Glycine Agents; Glycine Plasma Membrane Transport Proteins; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Kynurenic Acid; Neurons; Patch-Clamp Techniques; Pyridazines; Rats; Rats, Sprague-Dawley; Strychnine; Synapses | 2008 |
Tonic facilitation of glutamate release by glycine binding sites on presynaptic NR2B-containing NMDA autoreceptors in the rat visual cortex.
Topics: Animals; Animals, Newborn; Binding Sites; Dizocilpine Maleate; Drug Interactions; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Glycine; In Vitro Techniques; Kynurenic Acid; Patch-Clamp Techniques; Phenols; Piperidines; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Visual Cortex | 2008 |
Clozapine interacts with the glycine site of the NMDA receptor: electrophysiological studies of dopamine neurons in the rat ventral tegmental area.
Topics: Animals; Antipsychotic Agents; Brain Chemistry; Clozapine; Dose-Response Relationship, Drug; Glycine; Indomethacin; Kynurenic Acid; Male; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Ventral Tegmental Area | 2008 |
The integrity of the glycine co-agonist binding site of N-methyl-D-aspartate receptors is a functional quality control checkpoint for cell surface delivery.
Topics: Amino Acid Motifs; Binding Sites; Cell Line; Cell Membrane; Endoplasmic Reticulum; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Glycine; Humans; Kynurenic Acid; Point Mutation; Protein Binding; Protein Structure, Tertiary; Protein Subunits; Protein Transport; Receptors, N-Methyl-D-Aspartate | 2009 |
Effects of the beta-amino acid antagonist TAG on thalamocortical inhibition.
Topics: Animals; Benzothiadiazines; beta-Alanine; Bicuculline; Dose-Response Relationship, Drug; Glycine; Inhibitory Postsynaptic Potentials; Kynurenic Acid; Membrane Potentials; Patch-Clamp Techniques; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Glycine; Strychnine; Taurine; Thalamic Nuclei | 2009 |
Kinetic basis of partial agonism at NMDA receptors.
Topics: Action Potentials; Alanine; Amino Acids, Cyclic; Animals; Binding Sites; Cell Line; Cell Membrane; Cycloserine; Excitatory Amino Acid Agents; Glutamates; Glutamic Acid; Glycine; Humans; Kinetics; Kynurenic Acid; Models, Molecular; Rats; Receptors, N-Methyl-D-Aspartate | 2009 |
Intraperiaqueductal gray glycine and D-serine exert dual effects on rostral ventromedial medulla ON- and OFF-cell activity and thermoceptive threshold in the rat.
Topics: Action Potentials; Animals; Dose-Response Relationship, Drug; Drug Combinations; Excitatory Amino Acid Antagonists; Glycine; Kynurenic Acid; Male; Medulla Oblongata; Microinjections; Neural Pathways; Neurons; Pain Measurement; Pain Threshold; Periaqueductal Gray; Rats; Rats, Wistar; Reaction Time; Serine; Strychnine; Tail | 2009 |
Activation of N-methyl-D-aspartate (NMDA) receptors in the dorsal vagal complex lowers glucose production.
Topics: 2-Amino-5-phosphonovalerate; Animals; Gene Knockdown Techniques; Glucose; Glycine; Humans; Kynurenic Acid; Liver; Male; N-Methylaspartate; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Vagotomy; Vagus Nerve | 2010 |
Dependency of nociception facilitation or inhibition after periaqueductal gray matter stimulation on the context.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Formaldehyde; Glycine; Kynurenic Acid; Male; Microinjections; Pain; Pain Measurement; Periaqueductal Gray; Pyrrolidinones; Rats; Rats, Wistar | 2010 |
¹H NMR-based metabolic profiling of naproxen-induced toxicity in rats.
Topics: Animals; Choline; Dose-Response Relationship, Drug; Energy Metabolism; Glycine; Hydroxybutyrates; Kynurenic Acid; Magnetic Resonance Spectroscopy; Male; Naproxen; Pantothenic Acid; Phosphocreatine; Rats; Rats, Sprague-Dawley; Stomach; Tryptophan | 2011 |
Arrangement of subunits in functional NMDA receptors.
Topics: 4-Aminopyridine; Amino Acid Motifs; Analysis of Variance; Animals; Cell Line, Transformed; Copper Sulfate; Cysteine; Electric Stimulation; Excitatory Amino Acid Agents; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Humans; Kynurenic Acid; Membrane Potentials; Microinjections; Models, Molecular; Mutagenesis; Mutation; Oocytes; Patch-Clamp Techniques; Protein Structure, Tertiary; Protein Subunits; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Statistics, Nonparametric; Transfection; Xenopus | 2011 |
NMDA receptor glycine modulatory site in the ventral tegmental area regulates the acquisition, retrieval, and reconsolidation of cocaine reward memory.
Topics: Animals; Choice Behavior; Cocaine; Conditioning, Classical; Glycine; Kynurenic Acid; Male; Memory; Microinjections; Motor Activity; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reward; Substantia Nigra; Ventral Tegmental Area | 2012 |
Purinergic modulation of neuronal activity in developing auditory brainstem.
Topics: Acoustic Stimulation; Action Potentials; Adenosine Triphosphate; Age Factors; Analysis of Variance; Animals; Animals, Newborn; Brain Stem; Calcium; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; Female; Gerbillinae; Glycine; In Vitro Techniques; Kynurenic Acid; Male; Patch-Clamp Techniques; Psychoacoustics; Receptors, Purinergic P2X; Sensory Receptor Cells; Signal Transduction; Stilbamidines; Synaptic Potentials | 2012 |
An investigation of the antidepressant action of xiaoyaosan in rats using ultra performance liquid chromatography-mass spectrometry combined with metabonomics.
Topics: Animals; Antidepressive Agents; Benzoates; Biomarkers; Bridged-Ring Compounds; Catechin; Chalcone; Chromatography, Liquid; Citric Acid; Citric Acid Cycle; Coumaric Acids; Creatine Kinase; Creatinine; Cyclohexanols; Drugs, Chinese Herbal; Flavanones; Fluoxetine; Gallic Acid; Gastrointestinal Tract; Glucosides; Glycine; Hippurates; Ketoglutaric Acids; Kynurenic Acid; Male; Mass Spectrometry; Metabolic Networks and Pathways; Metabolomics; Microbiota; Monoterpenes; Phytotherapy; Plant Extracts; Rats; Rats, Sprague-Dawley; Stress, Psychological; Tryptophan; Tyrosine; Venlafaxine Hydrochloride | 2013 |
Most vesicles in a central nerve terminal participate in recycling.
Topics: Animals; Animals, Newborn; Biophysics; Brain Stem; Electric Stimulation; Endocytosis; Enzyme Inhibitors; Excitatory Amino Acid Agents; Excitatory Postsynaptic Potentials; Exocytosis; Female; Glutamic Acid; Glycine; In Vitro Techniques; Kynurenic Acid; Macrolides; Male; Patch-Clamp Techniques; Presynaptic Terminals; Rats; Rats, Wistar; Synaptic Transmission; Synaptic Vesicles | 2013 |
Novel nootropic drug sunifiram enhances hippocampal synaptic efficacy via glycine-binding site of N-methyl-D-aspartate receptor.
Topics: Animals; CA1 Region, Hippocampal; Dose-Response Relationship, Drug; Electrodes, Implanted; Excitatory Amino Acid Antagonists; Glycine; Kynurenic Acid; Long-Term Potentiation; Male; Mice; Mice, Inbred C57BL; Nootropic Agents; Piperazines; Piperidines; Polyamines; Protein Binding; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2013 |
Role of an excitatory preoptic-raphé pathway in febrile vasoconstriction of the rat's tail.
Topics: Animals; Dinoprostone; Excitatory Amino Acid Antagonists; Fever; Glycine; Kynurenic Acid; Male; Microinjections; Models, Animal; Muscimol; Preoptic Area; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Signal Transduction; Sympathetic Nervous System; Tail; Vasoconstriction | 2013 |
Novel hypoglycemic injury mechanism: N-methyl-D-aspartate receptor-mediated white matter damage.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Brain; Calcium; Disease Models, Animal; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Glycogen; Hydrogen-Ion Concentration; Hypoglycemia; Kynurenic Acid; Lactic Acid; Leukoencephalopathies; Mice; Mice, Inbred C57BL; Optic Nerve Injuries; Quinoxalines; Receptors, N-Methyl-D-Aspartate | 2014 |
A new function for glycine GlyT2 transporters: Stimulation of γ-aminobutyric acid release from cerebellar nerve terminals through GAT1 transporter reversal and Ca(2+)-dependent anion channels.
Topics: Analysis of Variance; Animals; Calcium; Calcium Channel Blockers; Cerebellum; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; GABA Agents; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Glycine; Glycine Agents; Glycine Plasma Membrane Transport Proteins; Kynurenic Acid; Male; Mice; Nerve Tissue Proteins; Nipecotic Acids; Synaptosomes; Tritium | 2014 |
Determination of 12 potential nephrotoxicity biomarkers in rat serum and urine by liquid chromatography with mass spectrometry and its application to renal failure induced by Semen Strychni.
Topics: Animals; Biomarkers; Chromatography, Liquid; Citric Acid; Creatinine; Drugs, Chinese Herbal; Glycine; Guanidines; Hippurates; Indican; Indoleacetic Acids; Kynurenic Acid; Male; Mass Spectrometry; Medicine, Chinese Traditional; Molecular Structure; Plant Extracts; Rats; Rats, Sprague-Dawley; Renal Insufficiency; Succinates; Taurine; Uric Acid; Xanthurenates | 2014 |
Glycine aggravates ischemia reperfusion-induced acute kidney injury through N-Methyl-D-Aspartate receptor activation in rats.
Topics: Acute Kidney Injury; Animals; Binding Sites; Glycine; Humans; Kidney; Kynurenic Acid; Rats; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury; Strychnine | 2014 |
Effects of systemic administration of kynurenic acid and glycine on renal haemodynamics and excretion in normotensive and spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Diuresis; Glycine; Hemodynamics; Hypertension; Kidney; Kynurenic Acid; Male; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Renal Circulation; Sodium | 2014 |
Concurrent antagonism of NMDA and AMPA receptors in the ventral tegmental area reduces the expression of conditioned approach learning in rats.
Topics: Animals; Conditioning, Psychological; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glycine; Kynurenic Acid; Male; Quinoxalines; Rats, Long-Evans; Receptors, AMPA; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Reward; Ventral Tegmental Area | 2016 |
The activation of metabotropic glutamate 5 receptors in the rat ventral tegmental area increases dopamine extracellular levels.
Topics: Animals; Dopamine; Excitatory Amino Acid Agents; Extracellular Fluid; Glutamic Acid; Glycine; Kynurenic Acid; Male; Microdialysis; Phenylacetates; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Thiazoles; Ventral Tegmental Area | 2017 |
Differential regulation of NMDA receptors by d-serine and glycine in mammalian spinal locomotor networks.
Topics: 2-Amino-5-phosphonovalerate; Animals; Efferent Pathways; Glycine; Interneurons; Kynurenic Acid; Mice; Mice, Inbred C57BL; Motor Activity; Racemases and Epimerases; Receptors, N-Methyl-D-Aspartate; Sarcosine; Serine; Spinal Nerve Roots; Synapses | 2017 |
Glutamate receptors of the A5 region modulate cardiovascular responses evoked from the dorsomedial hypothalamic nucleus and perifornical area.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Blood Pressure; Cardiovascular Physiological Phenomena; Dizocilpine Maleate; Dorsomedial Hypothalamic Nucleus; Electric Stimulation; Excitatory Amino Acid Antagonists; Fornix, Brain; Glycine; Heart Rate; Kynurenic Acid; Male; Microinjections; Rats; Receptors, Glutamate; Respiratory Rate; Tachycardia | 2018 |
Subsaturation of the N-methyl-D-aspartate receptor glycine site allows the regulation of bursting activity in juvenile rat nigral dopamine neurons.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dopaminergic Neurons; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Glycine; Kynurenic Acid; Pars Compacta; Phosphinic Acids; Propanolamines; Rats; Receptors, N-Methyl-D-Aspartate; Serine | 2019 |
Association Between Kidney Clearance of Secretory Solutes and Cardiovascular Events: The Chronic Renal Insufficiency Cohort (CRIC) Study.
Topics: Aged; Albuminuria; Chromatography, Liquid; Cohort Studies; Cresols; Female; Glomerular Filtration Rate; Glycine; Heart Failure; Humans; Incidence; Indican; Kidney Tubules; Kynurenic Acid; Male; Middle Aged; Myocardial Infarction; Organic Anion Transporters; Proportional Hazards Models; Prospective Studies; Pyridoxic Acid; Renal Insufficiency, Chronic; Ribonucleosides; Stroke; Sulfuric Acid Esters; Tandem Mass Spectrometry; Xanthines | 2021 |