kynurenic acid has been researched along with dizocilpine maleate in 171 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (6.43) | 18.7374 |
| 1990's | 120 (70.18) | 18.2507 |
| 2000's | 28 (16.37) | 29.6817 |
| 2010's | 12 (7.02) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Nicklas, WJ; Zeevalk, GD | 2 |
| Acuff, CG; Farley, JM; Ho, IK; Hoskins, B; Oden, G; Rockhold, RW; Surrett, RS; Zhang, T | 1 |
| Morimoto, K; Sato, M | 1 |
| Bowyer, JF; Frame, LT; Lipe, GW; Newport, GD | 1 |
| Dawes, E; Hankins, M; Ikeda, H | 1 |
| Ishii, T; Masu, M; Moriyoshi, K; Nakanishi, S; Sugihara, H | 1 |
| Abarca, J; Bradberry, CW; Bustos, G; Forray, MI; Gysling, K; Roth, RH | 1 |
| Peeters, BW; Vanderheyden, PM | 1 |
| Janssen, R | 1 |
| Dubner, R; Hylden, JL; Ren, K; Ruda, MA; Williams, GM | 1 |
| el-Asrar, AM; Maimone, D; Morse, PH; Reder, AT; Torczynski, E | 1 |
| Carling, RW; Donald, AE; Foster, AC; Grimwood, S; Kemp, JA; Leeson, PD; Marshall, GR; Priestley, T; Smith, JD | 1 |
| Fink, K; Göthert, M; Schultheiss, R | 1 |
| Gottesman, J; Miller, RF | 1 |
| Barun, S; Dalkara, T; Erdemli, G; Onur, R | 1 |
| Koyama, T; Nakamura, F; Ohmori, T; Yamashita, I | 1 |
| Bouzoukis, J; Choiniere, D; Wrathall, JR | 1 |
| Aamodt, SM; Kozlowski, MR; Nordeen, EJ; Nordeen, KW | 1 |
| DeFeo, PA; Hargrove, H; Patel, J; Salama, AI; Thompson, C; Zinkand, WC | 1 |
| Kihara, M; Kubo, T; Misu, Y | 1 |
| Baron, BM; Chi, EM; Harrison, BL; Kehne, JH; McCloskey, TC; Palfreyman, MG; Whitten, JP | 1 |
| Bandopadhyay, R; de Belleroche, J | 1 |
| Canton, H; Colpaert, F; Lehmann, J | 1 |
| Choi, DW; Goldberg, MP; Kaku, DA | 1 |
| Sircar, R; Zukin, SR | 1 |
| Andrew, M; Farley, JM; Ho, IK; Oden, G; Rockhold, RW | 1 |
| Cherubini, E; Kilić, G; Moran, O | 1 |
| Frusciante, MJ; Javitt, DC; Nussenzveig, IZ; Sircar, R; Wong, ML; Zukin, SR | 1 |
| Haesslein, JL; Hunt, PF; Jouanen, A; Massardier, D; Tremblet, AM | 1 |
| McCulloch, J | 1 |
| Rasmussen, K | 1 |
| Ben-Eliyahu, S; Gold, M; Liebeskind, JC; Marek, P | 1 |
| Lipton, P; Lobner, D | 1 |
| Compton, RP; Cordi, AA; Hood, WF; Monahan, JB; Williams, RM | 1 |
| Miyamoto, T; Okada, Y; Sakurai, T | 1 |
| Engberg, G; Hajós, M | 2 |
| Bowen, DM; Cross, AJ; Francis, PT; Green, AR; Steele, JE | 1 |
| Chiamulera, C; Costa, S; Reggiani, A | 1 |
| Keith, R; Patel, J; Salama, A; Thompson, C; Zinkand, WC | 1 |
| Pranzatelli, MR | 1 |
| Aizenman, E; Reynolds, IJ; Rush, EA | 1 |
| Horne, AL; Kemp, JA; McKernan, RM; Priestley, T | 1 |
| Herberg, LJ; Mintz, M; Rose, IC | 1 |
| Gill, R; Woodruff, GN | 1 |
| de Carolis, AS; Frank, C; Sagratella, S | 1 |
| Crossman, AR; Graham, WC; Robertson, RG; Sambrook, MA | 1 |
| McGeer, EG; McGeer, PL; Zhu, SG | 1 |
| Herberg, LJ; Rose, IC | 1 |
| Frusciante, MJ; Javitt, DC; Sircar, R; Zukin, SR | 1 |
| Johnson, KM; Sacaan, AI | 1 |
| Costa, E; Danysz, W; Fadda, E; Wroblewski, JT | 2 |
| Engberg, G | 1 |
| Davidoff, RA; Hackman, JC; Zhang, DX | 1 |
| Goto, Y; Ishida, M; Shinozaki, H | 1 |
| Desban, M; Gauchy, C; Glowinski, J; Kemel, ML; Krebs, MO | 1 |
| Payne, RS; Rigor, BM; Schurr, A | 1 |
| Anegawa, NJ; Lynch, DR; Pritchett, DB; Verdoorn, T | 1 |
| Laurie, DJ; Seeburg, PH | 1 |
| Baudry, M; Marvizón, JC | 2 |
| Anderson, LA; Kelland, MD; Soltis, RP; Walters, JR | 1 |
| Han, D; Ogita, K; Yoneda, Y | 2 |
| Hoffman, PL; Iorio, KR; Snell, LD; Tabakoff, B | 1 |
| Eki, T; Karp, SJ; Masu, M; Nakanishi, S; Ozawa, K | 1 |
| Bessho, Y; Nakanishi, S; Nawa, H | 1 |
| Mennini, T; Miari, A; Presti, ML; Rizzi, M; Samanin, R; Vezzani, A | 1 |
| Ammendola, D; De Sarro, A; De Sarro, G; Nava, F | 1 |
| Magistretti, PJ; Pellerin, L; Stella, N | 1 |
| Fibiger, HC; Taber, MT | 1 |
| Donevan, SD; Fielding, RP; Penix, L; Rho, JM; Rogawski, MA; Subramaniam, S | 1 |
| Nowak, G; Ordway, GA; Paul, IA | 1 |
| Barth, A; Malouf, AT; Newell, DW | 1 |
| Flores, A; Soto, E; Vega, R | 1 |
| Jessa, M; Nazar, M; Palejko, W; Plaznik, A | 1 |
| Haddad, GG; Jiang, C | 1 |
| Chan, PH; Chang, LH; Espanol, MT; James, TL; Litt, L; Weinstein, P; Xu, Y; Yang, GY | 1 |
| Frusciante, MJ; Javitt, DC; Zukin, SR | 1 |
| Hida, W; Kikuchi, Y; Kurosawa, H; Mizusawa, A; Ogawa, H; Okabe, S; Shirato, K; Takishima, T | 1 |
| Chan, PH; Chang, LH; Espanol, MT; James, TL; Litt, L; Weinstein, PR; Xu, Y | 1 |
| Berger, P; Farrel, K; Sharp, F; Skolnick, P | 1 |
| Greenamyre, JT; Porter, RH | 1 |
| Ball, GF; Wieraszko, A | 1 |
| Penney, JB; Sakurai, SY; Young, AB | 1 |
| Boje, KM; Skolnick, P; Wong, G | 1 |
| Bowery, NG; Gaviraghi, G; Marien, MR; Ratti, E; Tacconi, S | 1 |
| Layer, RT; Nowak, G; Paul, IA; Skolnick, P; Trullas, R | 1 |
| Hirai, H; Okada, Y | 1 |
| Corbett, R; Dunn, RW | 1 |
| Challiss, RA; Nahorski, SR; Simpson, PB | 1 |
| Bland, LR; Layer, RT; Skolnick, P | 1 |
| Chen, J; Graham, S; Moroni, F; Simon, R | 1 |
| Baran, H; Du, F; French, ED; McMaster, OG; Schwarcz, R; Wu, HQ | 1 |
| Kucharczyk, N; McCabe, RT; Sofia, RD; Vogel, JR; Wasterlain, CG | 1 |
| Cappendijk, SL; de Vries, R; Dzoljic, MR | 1 |
| Abrahams, TP; Gillis, RA; Hamosh, P; McManigle, JE; Taveira DaSilva, AM | 1 |
| Hamelin, SM; Lehmann, JC | 1 |
| Doyle, KM; Shaw, GG | 1 |
| London, ED; Matsunaga, T; Mukhin, AG | 1 |
| Chung, YT; Kim, SU; Lim, KT; Park, ST | 1 |
| Ault, B; Earley, WG; Hildebrand, LM; Kelly, MD; Luttinger, D; Mallamo, JP; Miller, MS; Ward, SJ | 1 |
| Aulakh, CS; Mazzola-Pomietto, P; Murphy, DL | 1 |
| Couratier, P; Dussartre, C; Hugon, J; Lesort, M; Terro, F | 1 |
| Beninger, RJ; Boegman, RJ; Flesher, S; Jhamandas, KH; Pawley, AC | 1 |
| Gondo, M; Goodman, JC; Robertson, CS; Simpson, RK | 1 |
| Johnson, SW; Wu, YN | 1 |
| Aizenman, E; Boeckman, FA | 1 |
| Gustafsson, B; Pananceau, M | 1 |
| Misawa, M; Suzuki, T; Tsuda, M | 2 |
| Arnelle, DR; Choi, YB; D'Emilia, DM; Kim, WK; Kumar, S; Lipton, SA; Rayudu, PV; Stamler, JS | 1 |
| Niu, YP; Wigstrom, H; Xiao, MY | 1 |
| Leibrock, J; Prücher, H; Rautenberg, W | 1 |
| Berger, R; Hossmann, KA; Jensen, A; Paschen, W | 1 |
| Kawabe, A; Maruoka, Y; Nakamura, M; Ohno, Y; Ohtani, K; Sakamoto, H; Tamamura, C; Tanaka, H; Yasuda, H | 1 |
| Chiang, CY; Hu, JW; Sessle, BJ | 1 |
| Ashby, CR; Katsumori, H; Minabe, Y; Osawa, M | 1 |
| Büyükuysal, RL | 1 |
| Cugola, A; Donati, D; Micheli, F; Missio, A; Pecunioso, A; Reggiani, A; Tarzia, G | 1 |
| Koch, M; Kretschmer, BD | 1 |
| Boje, KM; Lakhman, SS | 1 |
| Reynolds, IJ; Sharma, TA | 1 |
| Konieczny, J; Lorenc-Koci, E; Ossowska, K; Wolfarth, S | 1 |
| Hinoi, E; Ogita, K; St'astny, F; Yoneda, Y | 1 |
| Mazarati, AM; Wasterlain, CG | 1 |
| Liu, Y; von Euler, G | 1 |
| Cano, J; Machado, A; Merino, M; Vizuete, ML | 1 |
| Foldes, JK; Hauser, KF; Turbek, CS | 1 |
| Bunney, BS; Shi, WX; Zhang, XX | 1 |
| Allaf, R; Boulu, RG; Vistelle, R | 1 |
| Capdevila, J; Skolnick, P; Trullas, R; Viu, E; Zapata, A | 1 |
| Gemignani, A; Paudice, P; Pittaluga, A; Raiteri, M | 1 |
| Engberg, G; Erhardt, S | 2 |
| Harkin, A; Kelly, JP; Leonard, BE; Nally, R | 1 |
| Kotlińska, J | 1 |
| Klapka, N; Luhmann, HJ; Világi, I | 1 |
| Begon, S; Dubray, C; Eschalier, A; Mazur, A; Pickering, G; Rayssiguier, Y | 1 |
| Blantz, RC; Deng, A; Munger, KA; Thomson, SC; Valdivielso, JM | 1 |
| Bains, JS; Shaw, CA | 1 |
| Ito, A; Nagata, R; Nakamura, M; Ohtani, K; Tanaka, H; Yasuda, H; Yoneda, Y | 1 |
| Bakalkin, G; Esashi, A; Kisara, K; Nakagawasai, O; Niijima, F; Sakurada, C; Sakurada, T; Tadano, T; Tan-No, K; Terenius, L | 1 |
| Boros, A; Dezso, P; Kolok, S; Nagy, J; Szombathelyi, Z | 1 |
| Ogonowski, AA; Smith, JB | 1 |
| Hlinák, Z; Krejcí, I | 2 |
| Thio, LL; Yamada, KA | 1 |
| Concas, A; Marino, G; Minei, R; Pierobon, P; Porcu, P; Sogliano, C; Tino, A; Tortiglione, C | 1 |
| Cameron, JA; Chu, XP; Clayton, C; Henshall, DC; Lan, JQ; Meller, R; Schindler, CK; Simon, RP; Torrey, DJ; Xiong, ZG | 1 |
| Han, TZ; Li, YH | 1 |
| Esashi, A; Furuta, S; Nakagawasai, O; Niijima, F; Sato, T; Satoh, S; Tadano, T; Tan-No, K; Yasuhara, H | 1 |
| Su, DF; Wang, LG; Wang, WZ; Yuan, WJ; Zeng, J | 1 |
| Han, TZ; Li, YH; Meng, K | 1 |
| Dubrovina, NI; Zinovyev, DR; Zinovyeva, DV | 1 |
| Bobeck, EN; Ingram, SL; Morgan, MM | 1 |
| Dawid-Milner, MS; Díaz-Casares, A; González-Barón, S; López-González, MV; Peinado-Aragonés, CA | 1 |
| Camp, M; Debrouse, L; Grant, SG; Gunduz-Cinar, O; Holmes, A; Hurd, B; Kiselycznyk, C; Mishina, M; Plitt, A; Todaro, A | 1 |
| Andersen, M; Bergamaschi, CT; Campos, RR; Carillo, BA; Hipolide, D; Oliveira-Sales, EB; Santos, AA; Tucci, PJ; Tufik, S | 1 |
| Alfonso, S; Aow, J; Fox, R; Kessels, HW; Malinow, R; Nabavi, S | 1 |
| Czinege, Z; Farkas, T; Fülöp, F; Fuzik, J; Gellért, L; Herédi, J; Kis, Z; Knapp, L; Kocsis, K; Krucsó, E; Menyhárt, A; Nagy, D; Oláh, G; Párdutz, A; Tajti, J; Toldi, J; Vécsei, L | 1 |
| Banister, SD; Guillemin, GJ; Karl, T; Kassiou, M; Lim, CK; Purves-Tyson, T; Weickert, CS; Zavitsanou, K | 1 |
| Aguilera, P; Montes de Oca Balderas, P | 1 |
| Schwarcz, R; Snodgrass, HR; Yaksh, TL | 1 |
| Benyhe, S; Borsodi, A; Fülöp, F; Gáspár, R; Mándity, IM; Martos, D; Samavati, R; Szűcs, E; Tuka, B; Vécsei, L; Veres, G; Zádor, F | 1 |
| Biasibetti-Brendler, H; Ferreira, F; Pessoa-Pureur, R; Pierozan, P; Schmitz, F; Wyse, ATS | 1 |
| Barbancho, MA; Carrillo de Albornoz, M; Dawid-Milner, MS; Díaz-Casares, A; González-García, M; López-González, MV; Peinado-Aragonés, CA | 1 |
| Beckstead, MJ; Piccart, E; Tschumi, CW | 1 |
1 review(s) available for kynurenic acid and dizocilpine maleate
| Article | Year |
|---|---|
Afferent effects on locus coeruleus in opiate withdrawal.
Topics: Afferent Pathways; Animals; Cats; Clonidine; Dizocilpine Maleate; Kynurenic Acid; Locus Coeruleus; Morphine; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate; Second Messenger Systems; Substance Withdrawal Syndrome | 1991 |
170 other study(ies) available for kynurenic acid and dizocilpine maleate
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Developmental differences in antagonism of NMDA toxicity by the polyamine site antagonist ifenprodil.
Topics: Amino Acids; Animals; Biogenic Polyamines; Chick Embryo; Dizocilpine Maleate; Kynurenic Acid; N-Methylaspartate; Pipecolic Acids; Piperidines; Receptors, Glutamate; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine; Retina | 1992 |
Inhibition of cocaine intoxication by excitatory amino acid receptor antagonists.
Topics: Animals; Anticonvulsants; Cocaine; Death; Dextrorphan; Dizocilpine Maleate; Glutamates; Kynurenic Acid; Male; Mice; Mice, Inbred ICR; Neurotoxins; Piperazines; Receptors, Neurotransmitter; Seizures | 1992 |
NMDA receptor complex and kindling mechanisms.
Topics: Amygdala; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Electric Stimulation; Hippocampus; Kindling, Neurologic; Kynurenic Acid; Male; Neural Pathways; Pipecolic Acids; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses; Synaptic Transmission | 1992 |
A further evaluation of the effects of K+ depolarization on glutamate-evoked [3H]dopamine release from striatal slices.
Topics: Animals; Corpus Striatum; Culture Techniques; Dizocilpine Maleate; Dopamine; Excitatory Amino Acid Antagonists; Female; Glutamates; Glutamic Acid; Kynurenic Acid; Potassium; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter | 1992 |
Spontaneous firing level distinguishes the effects of NMDA and non-NMDA receptor antagonists on the ganglion cells in the cat retina.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Cats; Dizocilpine Maleate; Evoked Potentials, Visual; Ganglia; Iontophoresis; Kynurenic Acid; Piperazines; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Retina | 1992 |
Structures and properties of seven isoforms of the NMDA receptor generated by alternative splicing.
Topics: 2-Amino-5-phosphonovalerate; Amino Acid Sequence; Animals; Base Sequence; Chromosome Deletion; Cloning, Molecular; Dizocilpine Maleate; DNA; Gene Library; Kynurenic Acid; Molecular Sequence Data; N-Methylaspartate; Oocytes; Piperazines; Prosencephalon; Rats; Receptors, N-Methyl-D-Aspartate; Restriction Mapping; RNA Splicing; RNA, Messenger; Xenopus | 1992 |
Regulation of excitatory amino acid release by N-methyl-D-aspartate receptors in rat striatum: in vivo microdialysis studies.
Topics: Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Corpus Striatum; Dialysis; Dizocilpine Maleate; Extracellular Space; Fluorometry; Glutamates; Glutamic Acid; Kynurenic Acid; Male; N-Methylaspartate; Perfusion; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Serine | 1992 |
In vitro and in vivo characterization of the NMDA receptor-linked strychnine-insensitive glycine site.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Dizocilpine Maleate; Glycine; Kynurenic Acid; Male; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures; Serine; Stereoisomerism; Strychnine | 1992 |
Glutamate neurotoxicity in the developing rat cochlea is antagonized by kynurenic acid and MK-801.
Topics: Animals; Animals, Newborn; Audiometry; Cochlea; Dizocilpine Maleate; Evoked Potentials, Auditory, Brain Stem; Excitatory Amino Acid Antagonists; Female; Glutamates; Glutamic Acid; Kynurenic Acid; Male; Rats; Receptors, N-Methyl-D-Aspartate | 1992 |
The intrathecal administration of excitatory amino acid receptor antagonists selectively attenuated carrageenan-induced behavioral hyperalgesia in rats.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analgesics; Analysis of Variance; Animals; Behavior, Animal; Carrageenan; Dizocilpine Maleate; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hyperalgesia; Inflammation; Injections, Spinal; Ketamine; Kynurenic Acid; Male; Piperazines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Valine | 1992 |
MK-801 protects retinal neurons from hypoxia and the toxicity of glutamate and aspartate.
Topics: Animals; Culture Techniques; Dextromethorphan; Dizocilpine Maleate; Glutamates; Glutamic Acid; Hypoxia; Kynurenic Acid; N-Methylaspartate; Neurons; Rats; Rats, Inbred Strains; Retina | 1992 |
Kynurenic acid analogues with improved affinity and selectivity for the glycine site on the N-methyl-D-aspartate receptor from rat brain.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Brain; Cell Membrane; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Evoked Potentials; Glycine; Hippocampus; Ibotenic Acid; Kainic Acid; Kinetics; Kynurenic Acid; Male; Neurons; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Tritium | 1992 |
Stimulation of noradrenaline release in human cerebral cortex mediated by N-methyl-D-aspartate (NMDA) and non-NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adult; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Cerebral Cortex; Dizocilpine Maleate; Dose-Response Relationship, Drug; Female; Glycine; Humans; Ibotenic Acid; Kainic Acid; Kynurenic Acid; Magnesium; Male; N-Methylaspartate; Norepinephrine; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Tetrodotoxin; Tritium | 1992 |
Pharmacological properties of N-methyl-D-aspartate receptors on ganglion cells of an amphibian retina.
Topics: 2-Amino-5-phosphonovalerate; Ambystoma; Amino Acids; Animals; Anticonvulsants; Dizocilpine Maleate; Electrodes; In Vitro Techniques; Ion Channels; Kynurenic Acid; Magnesium; Perfusion; Receptors, N-Methyl-D-Aspartate; Retinal Ganglion Cells; Tetrodotoxin; Zinc | 1992 |
Glycine is required for NMDA receptor activation: electrophysiological evidence from intact rat hippocampus.
Topics: Animals; Dizocilpine Maleate; Electric Stimulation; Electrophysiology; Evoked Potentials; Glycine; Hippocampus; Iontophoresis; Ketamine; Kynurenic Acid; Magnesium; Male; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate; Time Factors | 1992 |
Amygdala kindling does not alter the N-methyl-D-aspartate receptor-channel complex which modulates dopamine release in the rat striatum and amygdala.
Topics: Amygdala; Animals; Corpus Striatum; Dizocilpine Maleate; Dopamine; In Vitro Techniques; Kindling, Neurologic; Kynurenic Acid; Male; Rats; Rats, Inbred WKY; Receptors, N-Methyl-D-Aspartate | 1992 |
Effect of kynurenate on functional deficits resulting from traumatic spinal cord injury.
Topics: Amino Acids; Analysis of Variance; Animals; Dextromethorphan; Dizocilpine Maleate; Female; Infusions, Intravenous; Injections, Spinal; Kynurenic Acid; Rats; Rats, Inbred Strains; Spinal Cord Injuries | 1992 |
Distribution and developmental change in [3H]MK-801 binding within zebra finch song nuclei.
Topics: Aging; Animals; Auditory Pathways; Autoradiography; Binding, Competitive; Birds; Dizocilpine Maleate; Image Processing, Computer-Assisted; Kynurenic Acid; Male; Neostriatum; Piperazines; Prosencephalon; Receptors, N-Methyl-D-Aspartate; Vocalization, Animal | 1992 |
Quisqualate neurotoxicity in rat cortical cultures: pharmacology and mechanisms.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Kynurenic Acid; N-Methylaspartate; Neurons; Quinoxalines; Quisqualic Acid; Rats; Receptors, N-Methyl-D-Aspartate | 1992 |
Ipsilateral but not contralateral blockade of excitatory amino acid receptors in the caudal ventrolateral medulla inhibits aortic baroreceptor reflex in rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aorta; Blood Pressure; Dizocilpine Maleate; Electric Stimulation; Glutamates; Glutamic Acid; Heart Rate; Kynurenic Acid; Male; Medulla Oblongata; Microinjections; Muscimol; N-Methylaspartate; Pressoreceptors; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Reflex; Synaptic Transmission | 1991 |
NMDA receptor complex antagonists have potential anxiolytic effects as measured with separation-induced ultrasonic vocalizations.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anti-Anxiety Agents; Anxiety, Separation; Behavior, Animal; Buspirone; Diazepam; Dioxins; Dizocilpine Maleate; Dose-Response Relationship, Drug; Indoles; Kynurenic Acid; Maternal Deprivation; Mephenesin; Piperidines; Quinolizines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Serotonin; Serotonin Antagonists; Spiro Compounds; Valine; Vocalization, Animal | 1991 |
Regulation of CCK release in cerebral cortex by N-methyl-D-aspartate receptors: sensitivity to APV, MK-801, kynurenate, magnesium and zinc ions.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cerebral Cortex; Dizocilpine Maleate; Kainic Acid; Kynurenic Acid; Magnesium; Male; N-Methylaspartate; Potassium; Quisqualic Acid; Radioimmunoassay; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Sincalide; Zinc | 1991 |
Glutamate and glycine co-activate while polyamines merely modulate the NMDA receptor complex.
Topics: 2-Amino-5-phosphonovalerate; Adrenergic alpha-Antagonists; Animals; Biguanides; Binding, Competitive; Biogenic Polyamines; Biotransformation; Brain; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; Kynurenic Acid; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine | 1991 |
Antagonism of non-NMDA receptors augments the neuroprotective effect of NMDA receptor blockade in cortical cultures subjected to prolonged deprivation of oxygen and glucose.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Culture Media; Dizocilpine Maleate; Fetus; Glucose; Kynurenic Acid; Mice; Neurons; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1991 |
Kinetic mechanisms of glycine requirement for N-methyl-D-aspartate channel activation.
Topics: Animals; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Kinetics; Kynurenic Acid; Male; Models, Biological; Prosencephalon; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Synaptosomes | 1991 |
Glutamate receptor antagonists block cocaine-induced convulsions and death.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Anticonvulsants; Cocaine; Death; Dextrorphan; Dizocilpine Maleate; Dose-Response Relationship, Drug; Glutamates; Kynurenic Acid; Male; Mice; Mice, Inbred ICR; Piperazines; Quinoxalines; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures; Time Factors | 1991 |
N-methyl-D-aspartate receptor-mediated spontaneous activity in cerebellar granule cells in culture.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Calcium Channels; Cells, Cultured; Cerebellum; Cobalt; Dizocilpine Maleate; Glutamates; Glutamic Acid; Kynurenic Acid; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Tetrodotoxin | 1991 |
Polyamine effects upon N-methyl-D-aspartate receptor functioning: differential alteration by glutamate and glycine site antagonists.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding Sites; Cell Membrane; Cerebral Cortex; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Hippocampus; Kinetics; Kynurenic Acid; Male; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Spermidine | 1991 |
GABA release from mouse striatal neurons in primary culture as a test for the functional activity of N-methyl-D-aspartate (NMDA) antagonists.
Topics: Animals; Cells, Cultured; Corpus Striatum; Dizocilpine Maleate; Female; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Ion Channels; Kynurenic Acid; Ligands; Mice; N-Methylaspartate; Neurons; Pregnancy; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1991 |
Ischaemic brain damage--prevention with competitive and non-competitive antagonists of N-methyl-D-aspartate receptors.
Topics: Animals; Cats; Cerebral Arteries; Dextrorphan; Dizocilpine Maleate; Hematoma, Subdural; Ischemic Attack, Transient; Kynurenic Acid; Phencyclidine; Piperazines; Rats; Receptors, N-Methyl-D-Aspartate | 1991 |
Excitatory amino acid antagonists (kynurenic acid and MK-801) attenuate the development of morphine tolerance in the rat.
Topics: Analgesia; Animals; Dizocilpine Maleate; Drug Tolerance; Kynurenic Acid; Male; Morphine; Rats; Rats, Inbred Strains | 1991 |
Sigma-ligands and non-competitive NMDA antagonists inhibit glutamate release during cerebral ischemia.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Cyclazocine; Dizocilpine Maleate; Glutamates; Guanidines; Haloperidol; Hippocampus; In Vitro Techniques; Ischemic Attack, Transient; Ketamine; Kynurenic Acid; Male; Models, Neurological; Phencyclidine; Pyramidal Tracts; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Receptors, sigma | 1990 |
Identification of a novel structural class of positive modulators of the N-methyl-D-aspartate receptor, with actions mediated through the glycine recognition site.
Topics: Amino Acids; Animals; Brain; Dizocilpine Maleate; Glycine; In Vitro Techniques; Kinetics; Kynurenic Acid; Male; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Stereoisomerism; Structure-Activity Relationship; Synaptic Membranes | 1990 |
Masking effect of NMDA receptor antagonists on the formation of long-term potentiation (LTP) in superior colliculus slices from the guinea pig.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Denervation; Dibenzocycloheptenes; Dipeptides; Dizocilpine Maleate; Evoked Potentials; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; In Vitro Techniques; Kynurenic Acid; Magnesium; Mice; Nerve Degeneration; Optic Nerve; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Superior Colliculi; Visual Cortex | 1990 |
Kynurenic acid blocks chemogenic nociception.
Topics: Animals; Behavior, Animal; Capsaicin; Cisterna Magna; Dizocilpine Maleate; Injections; Kynurenic Acid; Male; Nociceptors; Pain; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1990 |
Spermidine enhancement of [3H]MK-801 binding to the NMDA receptor complex in human cortical membranes.
Topics: Adrenergic alpha-Antagonists; Aged; Aged, 80 and over; Cerebral Cortex; Dizocilpine Maleate; Female; Humans; In Vitro Techniques; Kynurenic Acid; Male; Membranes; Piperidines; Radioligand Assay; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spermidine | 1990 |
Effect of NMDA- and strychnine-insensitive glycine site antagonists on NMDA-mediated convulsions and learning.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Injections, Intraventricular; Kynurenic Acid; Learning; Male; Mice; N-Methylaspartate; Piperazines; Receptors, Glycine; Receptors, Neurotransmitter; Seizures; Strychnine | 1990 |
Role of glycine in the N-methyl-D-aspartate-mediated neuronal cytotoxicity.
Topics: Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Glycine; Kynurenic Acid; N-Methylaspartate; Neurons; Piperazines; Pyrrolidinones; Serine | 1990 |
Antimyoclonic effect of MK-801: a possible role for NMDA receptors in developmental myoclonus of the neonatal rat.
Topics: Aminobutyrates; Analysis of Variance; Animals; Animals, Newborn; Anticonvulsants; Clonazepam; Diazepam; Dizocilpine Maleate; Dose-Response Relationship, Drug; Female; Isoxazoles; Kynurenic Acid; Male; Myoclonus; N-Methylaspartate; Quisqualic Acid; Rats; Receptors, N-Methyl-D-Aspartate; Strychnine | 1990 |
Reduction of NMDA receptors with dithiothreitol increases [3H]-MK-801 binding and NMDA-induced Ca2+ fluxes.
Topics: Animals; Calcium; Dithionitrobenzoic Acid; Dithiothreitol; Dizocilpine Maleate; Fluorescence; Fura-2; Glutamates; Glycine; In Vitro Techniques; Kynurenic Acid; N-Methylaspartate; Pipecolic Acids; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine | 1990 |
The effect of NMDA receptor glycine site antagonists on hypoxia-induced neurodegeneration of rat cortical cell cultures.
Topics: Animals; Binding Sites; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Fetus; Glycine; Hypoxia; Kinetics; Kynurenic Acid; L-Lactate Dehydrogenase; Nerve Degeneration; Neurons; Phosphopyruvate Hydratase; Pyrrolidinones; Rats; Receptors, N-Methyl-D-Aspartate | 1990 |
The effect of the NMDA receptor antagonist, MK-801, on the course and outcome of kindling.
Topics: Animals; Anticonvulsants; Clonazepam; Dibenzocycloheptenes; Dizocilpine Maleate; Kindling, Neurologic; Kynurenic Acid; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
A role of excitatory amino acids in the activation of locus coeruleus neurons following cutaneous thermal stimuli.
Topics: Afferent Pathways; Amino Acids; Animals; Dizocilpine Maleate; Hot Temperature; Injections, Intraventricular; Kynurenic Acid; Locus Coeruleus; Male; Medulla Oblongata; Neurons, Afferent; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Skin | 1990 |
The neuroprotective actions of kynurenic acid and MK-801 in gerbils are synergistic and not related to hypothermia.
Topics: Animals; Body Temperature; Brain; Carotid Arteries; Dibenzocycloheptenes; Dizocilpine Maleate; Drug Synergism; Gerbillinae; Ischemic Attack, Transient; Kynurenic Acid; Neurons; Pyramidal Tracts | 1990 |
Inhibitory influence of excitatory amino acid antagonists on penicillin-induced epileptiform bursting in rat hippocampal slices.
Topics: Amino Acids; Animals; Anticonvulsants; Dibenzocycloheptenes; Dizocilpine Maleate; Electric Stimulation; Electrophysiology; Epilepsy; Hippocampus; In Vitro Techniques; Kynurenic Acid; Male; Penicillins; Rats; Rats, Inbred Strains | 1990 |
Injection of excitatory amino acid antagonists into the medial pallidal segment of a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treated primate reverses motor symptoms of parkinsonism.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Amino Acids; Animals; Dizocilpine Maleate; Female; Globus Pallidus; Infusion Pumps; Kynurenic Acid; Macaca fascicularis; Parkinson Disease, Secondary | 1990 |
Effect of MK-801, kynurenate, glycine, dextrorphan and 4-acetylpyridine on striatal toxicity of quinolinate.
Topics: Animals; Choline O-Acetyltransferase; Corpus Striatum; Dextrorphan; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Glutamate Decarboxylase; Glycine; Kynurenic Acid; Male; Neurotoxins; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains | 1989 |
The effect of MK-801 and other antagonists of NMDA-type glutamate receptors on brain-stimulation reward.
Topics: Animals; Anticonvulsants; Aspartic Acid; Brain; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Ketamine; Kynurenic Acid; Male; N-Methylaspartate; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Self Stimulation | 1989 |
Acute excitotoxicity in chick retina caused by the unusual amino acids BOAA and BMAA: effects of MK-801 and kynurenate.
Topics: Amino Acids, Diamino; Animals; Aspartic Acid; beta-Alanine; Chick Embryo; Cyanobacteria Toxins; Dibenzocycloheptenes; Dizocilpine Maleate; gamma-Aminobutyric Acid; Glutamates; Histocytochemistry; Kynurenic Acid; N-Methylaspartate; Neurons; Neurotoxins; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Retina | 1989 |
Glycine reverses 7-chlorokynurenic acid-induced inhibition of [3H]MK-801 binding.
Topics: Animals; Dibenzocycloheptenes; Dizocilpine Maleate; Glycine; Kynurenic Acid; Male; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine | 1989 |
Spermine enhances binding to the glycine site associated with the N-methyl-D-aspartate receptor complex.
Topics: Animals; Dibenzocycloheptenes; Dizocilpine Maleate; Glycine; Kinetics; Kynurenic Acid; Magnesium; Rats; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spermine | 1989 |
Kynurenate and 2-amino-5-phosphonovalerate interact with multiple binding sites of the N-methyl-D-aspartate-sensitive glutamate receptor domain.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Binding Sites; Binding, Competitive; Brain; Dibenzocycloheptenes; Dizocilpine Maleate; Kynurenic Acid; Piperazines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Strychnine; Subcellular Fractions; Valine | 1989 |
Nicotine induced excitation of locus coeruleus neurons is mediated via release of excitatory amino acids.
Topics: Action Potentials; Amino Acids; Animals; Dibenzocycloheptenes; Dizocilpine Maleate; Glutamates; Glutamic Acid; Kynurenic Acid; Locus Coeruleus; Male; Neurons; Nicotine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
NMDA antagonists and potentiation of NMDA-induced motoneuron depolarizations in the isolated frog spinal cord.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Cell Membrane; Dibenzocycloheptenes; Dizocilpine Maleate; Drug Synergism; Evoked Potentials; Ketamine; Kynurenic Acid; Magnesium; Motor Neurons; N-Methylaspartate; Potassium; Rana pipiens; Spinal Cord; Valine | 1989 |
Different modes of action of 3-amino-1-hydroxy-2-pyrrolidone (HA-966) and 7-chlorokynurenic acid in the modulation of N-methyl-D-aspartate-sensitive glutamate receptors.
Topics: Animals; Dibenzocycloheptenes; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; Kynurenic Acid; Piperazines; Protein Conformation; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Depression of decerebrate rigidity in the rat by antagonists of excitatory amino acids.
Topics: Amino Acids; Animals; Anticonvulsants; Azepines; Blood Pressure; Decerebrate State; Dibenzocycloheptenes; Dizocilpine Maleate; Ketamine; Kynurenic Acid; Male; Muscle Relaxants, Central; Muscle Rigidity; Oxazoles; Oxazolidinones; Piperazines; Rats; Rats, Inbred Strains | 1989 |
Glycine potentiates the NMDA-induced release of dopamine through a strychnine-insensitive site in the rat striatum.
Topics: Animals; Aspartic Acid; Corpus Striatum; Dibenzocycloheptenes; Dizocilpine Maleate; Dopamine; Drug Synergism; Glycine; In Vitro Techniques; Kynurenic Acid; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Strychnine | 1989 |
Protection by MK-801 against hypoxia-, excitotoxin-, and depolarization-induced neuronal damage in vitro.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anti-Anxiety Agents; Benzodiazepines; Diltiazem; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hippocampus; Hypoxia, Brain; In Vitro Techniques; Kynurenic Acid; Membrane Potentials; Neurons; Nifedipine; Pipecolic Acids; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 1995 |
N-methyl-D-aspartate receptors: different subunit requirements for binding of glutamate antagonists, glycine antagonists, and channel-blocking agents.
Topics: Binding Sites; Cells, Cultured; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Glycine; Humans; Ion Channels; Kynurenic Acid; Receptors, N-Methyl-D-Aspartate; Transfection | 1994 |
Ligand affinities at recombinant N-methyl-D-aspartate receptors depend on subunit composition.
Topics: 2-Amino-5-phosphonovalerate; Animals; Autoradiography; Binding Sites; Binding, Competitive; Brain; Cloning, Molecular; Dizocilpine Maleate; DNA; Glutamic Acid; Ion Channels; Kinetics; Kynurenic Acid; Ligands; Rats; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins | 1994 |
Allosteric interactions and modulator requirement for NMDA receptor function.
Topics: Allosteric Regulation; Animals; Brain Chemistry; Dizocilpine Maleate; Glutamic Acid; Glycine; In Vitro Techniques; Ion Channels; Kynurenic Acid; Male; Membranes; Protein Conformation; Rats; Rats, Sprague-Dawley; Receptors, Biogenic Amine; Receptors, N-Methyl-D-Aspartate; Spermine | 1994 |
A role for non-NMDA excitatory amino acid receptors in regulating the basal activity of rat globus pallidus neurons and their activation by the subthalamic nucleus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Bicuculline; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Extracellular Space; GABA-A Receptor Antagonists; Globus Pallidus; Kynurenic Acid; Male; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Thalamic Nuclei | 1994 |
Potentiation by calcium ions of [3H]MK-801 binding to an ion channel associated with the N-methyl-D-aspartate receptor complex in rat brain.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium; Dizocilpine Maleate; Ion Channels; Kynurenic Acid; Male; Phospholipases; Phospholipases A; Protein Binding; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synaptic Membranes | 1995 |
Attenuation of glutamate-induced neurotoxicity in chronically ethanol-exposed cerebellar granule cells by NMDA receptor antagonists and ganglioside GM1.
Topics: Alcohol Withdrawal Delirium; Alcoholism; Animals; Animals, Newborn; Cells, Cultured; Cerebellum; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; G(M1) Ganglioside; Glutamic Acid; Kynurenic Acid; Neurons; Pipecolic Acids; Rats; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Up-Regulation | 1995 |
Molecular cloning and chromosomal localization of the key subunit of the human N-methyl-D-aspartate receptor.
Topics: 2-Amino-5-phosphonovalerate; Amino Acid Sequence; Animals; Base Sequence; Brain; Chromosome Mapping; Chromosomes, Human, Pair 9; Cricetinae; Dizocilpine Maleate; DNA; Humans; Hybrid Cells; Karyotyping; Kynurenic Acid; Macromolecular Substances; Magnesium; Molecular Sequence Data; N-Methylaspartate; Oocytes; Poly A; Receptors, N-Methyl-D-Aspartate; RNA; RNA, Messenger; Temporal Lobe; Xenopus; Zinc | 1993 |
Glutamate receptor agonists enhance the expression of BDNF mRNA in cultured cerebellar granule cells.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain-Derived Neurotrophic Factor; Cell Survival; Cells, Cultured; Cerebellum; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Ibotenic Acid; Kainic Acid; Kinetics; Kynurenic Acid; Molecular Weight; N-Methylaspartate; Nerve Growth Factors; Nerve Tissue Proteins; Quinoxalines; Quisqualic Acid; Rats; Rats, Sprague-Dawley; RNA; RNA, Messenger; Tetrodotoxin; Transcription, Genetic | 1993 |
Adaptive changes in the NMDA receptor complex in rat hippocampus after chronic treatment with CGP 39551.
Topics: 2-Amino-5-phosphonovalerate; Animals; Autoradiography; Dizocilpine Maleate; Glutamic Acid; Hippocampus; Kynurenic Acid; Male; Norepinephrine; Phencyclidine; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1994 |
Effects of some excitatory amino acid antagonists on imipenem-induced seizures in DBA/2 mice.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids; Animals; Anticonvulsants; Dizocilpine Maleate; Excitatory Amino Acids; Glutamine; Imipenem; Kynurenic Acid; Mice; Mice, Inbred DBA; Muscimol; Piperazines; Piperidines; Quinoxalines; Seizures | 1995 |
Modulation of the glutamate-evoked release of arachidonic acid from mouse cortical neurons: involvement of a pH-sensitive membrane phospholipase A2.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amiloride; Ammonium Chloride; Animals; Arachidonic Acid; Calcium; Cell Membrane; Cell Survival; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Embryo, Mammalian; Female; Glutamic Acid; Harmaline; Hydrogen-Ion Concentration; Immunohistochemistry; Kainic Acid; Kinetics; Kynurenic Acid; Mice; N-Methylaspartate; Neurons; Phospholipases A; Phospholipases A2; Pregnancy; Time Factors; Tritium | 1995 |
Electrical stimulation of the prefrontal cortex increases dopamine release in the nucleus accumbens of the rat: modulation by metabotropic glutamate receptors.
Topics: Animals; Cycloleucine; Dizocilpine Maleate; Dopamine; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Antagonists; Kinetics; Kynurenic Acid; Male; Microdialysis; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Wistar; Tetrodotoxin; Time Factors | 1995 |
Felbamate block of the N-methyl-D-aspartate receptor.
Topics: Animals; Anticonvulsants; Cells, Cultured; Dizocilpine Maleate; Felbamate; Kynurenic Acid; Membrane Potentials; Phenylcarbamates; Propylene Glycols; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tritium | 1995 |
Alterations in the N-methyl-D-aspartate (NMDA) receptor complex in the frontal cortex of suicide victims.
Topics: 2-Amino-5-phosphonovalerate; Adult; Dizocilpine Maleate; Female; Frontal Lobe; Humans; In Vitro Techniques; Kynurenic Acid; Male; Middle Aged; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Suicide | 1995 |
Glycine site NMDA receptor antagonists provide protection against ischemia-induced neuronal damage in hippocampal slice cultures.
Topics: Animals; Brain Ischemia; Cell Death; Dizocilpine Maleate; Glycine; Glycine Agents; Hippocampus; Kynurenic Acid; Neurons; Organ Culture Techniques; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 1995 |
NMDA-mediated potentiation of the afferent synapse in the inner ear.
Topics: 2-Amino-5-phosphonovalerate; Ambystoma; Amplifiers, Electronic; Animals; Dizocilpine Maleate; Electrophysiology; Glycine; In Vitro Techniques; Kynurenic Acid; N-Methylaspartate; Neurons, Afferent; Physical Stimulation; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Synapses; Vestibule, Labyrinth | 1994 |
Effects of antagonists at the NMDA receptor complex in two models of anxiety.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anxiety; Behavior, Animal; Conflict, Psychological; Diazepam; Dizocilpine Maleate; Drinking; Electroshock; Exploratory Behavior; Injections, Intraventricular; Kynurenic Acid; Male; Motor Activity; Rats; Rats, Wistar; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 1994 |
Mechanisms of anoxia-induced depolarization in brainstem neurons: in vitro current and voltage clamp studies in the adult rat.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Adenosine Triphosphate; Animals; Brain Stem; Dizocilpine Maleate; Glutamates; Glutamic Acid; Hypoxia, Brain; In Vitro Techniques; Kynurenic Acid; Membrane Potentials; Microelectrodes; Neurons; Neurotransmitter Agents; Quinoxalines; Rats; Sodium | 1993 |
Modulation of glutamate-induced intracellular energy failure in neonatal cerebral cortical slices by kynurenic acid, dizocilpine, and NBQX.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Cerebral Cortex; Dizocilpine Maleate; Energy Metabolism; Glutamates; Glutamic Acid; In Vitro Techniques; Intracellular Membranes; Kynurenic Acid; Neurotoxins; Phosphocreatine; Quinoxalines; Rats; Rats, Sprague-Dawley | 1994 |
Activation-related and activation-independent effects of polyamines on phencyclidine receptor binding within the N-methyl-D-aspartate receptor complex.
Topics: Animals; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; Kinetics; Kynurenic Acid; Male; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Phencyclidine; Spermidine | 1994 |
Preferential induction by stress of the N-methyl-D-aspartate recognition domain in discrete structures of rat brain.
Topics: 2-Amino-5-phosphonovalerate; Adrenal Cortex Hormones; Animals; Autoradiography; Behavior, Animal; Brain Chemistry; Cerebellum; Corpus Striatum; Cycloheximide; Dizocilpine Maleate; Dose-Response Relationship, Drug; Glycine; Hypothalamus; Kynurenic Acid; Male; N-Methylaspartate; Rats; Rats, Wistar; Stress, Physiological; Tritium | 1994 |
In vivo release of glutamate in nucleus tractus solitarii of the rat during hypoxia.
Topics: Animals; Blood Pressure; Carotid Body; Chemoreceptor Cells; Denervation; Dizocilpine Maleate; Doxapram; Glutamic Acid; Heart Rate; Hypoxia; Infusions, Intravenous; Kynurenic Acid; Male; Microinjections; Rats; Rats, Sprague-Dawley; Respiration; Solitary Nucleus | 1994 |
Modulation of edema by dizocilpine, kynurenate, and NBQX in respiring brain slices after exposure to glutamate.
Topics: Animals; Brain Edema; Cerebral Cortex; Culture Techniques; Dizocilpine Maleate; Energy Metabolism; Glutamic Acid; Kynurenic Acid; Magnetic Resonance Spectroscopy; Organ Size; Quinoxalines; Rats; Receptors, AMPA; Receptors, Glutamate; Sodium Channels | 1994 |
Drugs acting at the strychnine-insensitive glycine receptor do not induce HSP-70 protein in the cingulate cortex.
Topics: Amino Acids; Amino Acids, Cyclic; Animals; Dizocilpine Maleate; Gyrus Cinguli; Heat-Shock Proteins; Hippocampus; Immunohistochemistry; Kynurenic Acid; Male; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Strychnine | 1994 |
Inhibition of autoradiographic MK-801 binding by an endogenous factor.
Topics: Animals; Autoradiography; Brain Chemistry; Dizocilpine Maleate; Isoquinolines; Kynurenic Acid; Ligands; Rats; Receptors, N-Methyl-D-Aspartate | 1994 |
NMDA receptor activation by spermine requires glutamate but not glycine.
Topics: Animals; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Kynurenic Acid; Male; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermine | 1993 |
Long-term potentiation in the avian hippocampus does not require activation of the N-methyl-D-aspartate (NMDA) receptor.
Topics: 2-Amino-5-phosphonovalerate; Animals; Columbidae; Dizocilpine Maleate; Evoked Potentials; Hippocampus; In Vitro Techniques; Kynurenic Acid; Receptors, N-Methyl-D-Aspartate; Synapses | 1993 |
Regionally distinct N-methyl-D-aspartate receptors distinguished by quantitative autoradiography of [3H]MK-801 binding in rat brain.
Topics: Animals; Autoradiography; Brain; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Kinetics; Kynurenic Acid; Male; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tissue Distribution; Tritium | 1993 |
Desensitization of the NMDA receptor complex by glycinergic ligands in cerebellar granule cell cultures.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Amino Acids, Cyclic; Analysis of Variance; Animals; Base Sequence; Blotting, Northern; Cells, Cultured; Cerebellum; Dizocilpine Maleate; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Glycine; Kinetics; Kynurenic Acid; Molecular Sequence Data; Neurons; Neurotoxins; Oligodeoxyribonucleotides; Polymerase Chain Reaction; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Strychnine; Time Factors | 1993 |
Inhibition of [3H]-(+)-MK 801 binding to rat brain sections by CPP and 7-chlorokynurenic acid: an autoradiographic analysis.
Topics: Animals; Autoradiography; Brain; Cerebellum; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Image Processing, Computer-Assisted; In Vitro Techniques; Kynurenic Acid; Male; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1993 |
Adaptive changes in the N-methyl-D-aspartate receptor complex after chronic treatment with imipramine and 1-aminocyclopropanecarboxylic acid.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Amino Acids, Cyclic; Animals; Brain; Dizocilpine Maleate; Drug Administration Schedule; Glycine; Imipramine; In Vitro Techniques; Kynurenic Acid; Male; Mice; Receptors, N-Methyl-D-Aspartate | 1993 |
Serine released from hippocampal slices during deprivation of oxygen and glucose enhances the effects of glutamate on neuronal function.
Topics: Adenosine Triphosphate; Amino Acids; Animals; Dizocilpine Maleate; Glucose; Glutamates; Glutamic Acid; Guinea Pigs; Hippocampus; Hypoxia; In Vitro Techniques; Kynurenic Acid; Neurons; Phosphocreatine; Receptors, N-Methyl-D-Aspartate; Serine; Synaptic Transmission | 1993 |
Effects of 5,7 dichlorokynurenic acid on conflict, social interaction and plus maze behaviors.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Behavior, Animal; Conflict, Psychological; Diazepam; Discrimination Learning; Dizocilpine Maleate; Glycine; Kynurenic Acid; Male; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Social Behavior | 1993 |
Potentiation of N-methyl-D-aspartate-evoked elevation of intracellular Ca2+ concentrations by exogenous glycine in cerebellar granule cells.
Topics: Animals; Calcium; Calcium Channel Agonists; Cells, Cultured; Cerebellum; Dizocilpine Maleate; Glycine; Kynurenic Acid; Nicotinic Acids; Oxadiazoles; Rats; Receptors, N-Methyl-D-Aspartate | 1994 |
MK-801, but not drugs acting at strychnine-insensitive glycine receptors, attenuate methamphetamine nigrostriatal toxicity.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amino Acids; Amino Acids, Cyclic; Animals; Corpus Striatum; Dizocilpine Maleate; Dopamine; Kynurenic Acid; Male; Methamphetamine; Mice; Mice, Inbred Strains; Receptors, Glycine; Strychnine; Substantia Nigra | 1993 |
A study of the dose dependency of a glycine receptor antagonist in focal ischemia.
Topics: Animals; Brain; Brain Chemistry; Brain Diseases; Brain Ischemia; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Free Radical Scavengers; Heat-Shock Proteins; Immunohistochemistry; Kynurenic Acid; Male; Rats; Rats, Sprague-Dawley; Receptors, Glycine | 1993 |
gamma-Acetylenic GABA produces axon-sparing neurodegeneration after focal injection into the rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminobutyrate Transaminase; Alkynes; Amino Acids; Aminocaproates; Animals; Anticonvulsants; Axons; Choline O-Acetyltransferase; Dizocilpine Maleate; Hippocampus; In Vitro Techniques; Kynurenic Acid; Lyases; Male; Nerve Degeneration; Neurons; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Stereotaxic Techniques; Transaminases | 1993 |
Evidence for anticonvulsant and neuroprotectant action of felbamate mediated by strychnine-insensitive glycine receptors.
Topics: Animals; Anticonvulsants; Brain; Dizocilpine Maleate; Felbamate; Female; In Vitro Techniques; Kynurenic Acid; Male; Neurons; Phenylcarbamates; Propylene Glycols; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, Neurotransmitter; Strychnine | 1993 |
Excitatory amino acid receptor antagonists and naloxone-precipitated withdrawal syndrome in morphine-dependent mice.
Topics: Animals; Behavior, Animal; Dizocilpine Maleate; Glycine; Kynurenic Acid; Male; Mice; Morphine Dependence; Naloxone; Quinoxalines; Receptors, Amino Acid; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Substance Withdrawal Syndrome | 1993 |
Cardiorespiratory effects produced by blockade of excitatory amino acid receptors in cats.
Topics: Animals; Blood Pressure; Carotid Sinus; Cats; Denervation; Dizocilpine Maleate; Female; Heart Rate; Injections, Intravenous; Kynurenic Acid; Male; Receptors, Amino Acid; Receptors, N-Methyl-D-Aspartate; Respiration; Tidal Volume; Trachea; Vagus Nerve | 1993 |
Effects of putative cognition enhancers on the NMDA receptor by [3H]MK801 binding.
Topics: Animals; Binding, Competitive; Cognition; Cycloserine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Combinations; Kynurenic Acid; Piracetam; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1995 |
Investigation of the involvement of the N-methyl-D-aspartate receptor macrocomplex in the development of spermine-induced CNS excitation in vivo.
Topics: Animals; Brain; Cerebral Ventricles; Dizocilpine Maleate; Female; Kynurenic Acid; Mice; Neuroprotective Agents; Piperazines; Piperidines; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Seizures; Spermine; Tremor | 1996 |
Regionally distinct stoichiometry for N-methyl-D-aspartate receptor domains in brain.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Brain Chemistry; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; In Vitro Techniques; Kinetics; Kynurenic Acid; Male; Nerve Tissue Proteins; Radioligand Assay; Rats; Rats, Inbred F344; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 1996 |
Methylmercury-induced neurotoxicity in cerebral neuron culture is blocked by antioxidants and NMDA receptor antagonists.
Topics: Animals; Antioxidants; Catalase; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutathione; Kynurenic Acid; Methylmercury Compounds; Mice; Neurons; Receptors, N-Methyl-D-Aspartate | 1996 |
WIN 63480, a hydrophilic TCP-site ligand, has reduced agonist-independent NMDA ion channel access compared to MK-801 and phencyclidine.
Topics: Animals; Binding Sites; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Kynurenic Acid; Membrane Potentials; Mice; Phencyclidine; Quinolizines; Receptors, N-Methyl-D-Aspartate; Transfection; Xenopus laevis | 1995 |
NMDA receptor antagonists block development of tolerance to m-CPP-induced increases in ACTH concentrations in rats.
Topics: Adrenocorticotropic Hormone; Animals; Dimethyl Sulfoxide; Dizocilpine Maleate; Drug Tolerance; Kynurenic Acid; Male; Phencyclidine; Piperazines; Piperidines; Pyrrolidinones; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Serotonin Receptor Agonists | 1996 |
NMDA antagonist blockade of AT8 tau immunoreactive changes in neuronal cultures.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cell Survival; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; Fetus; Fluorescent Antibody Technique; Kynurenic Acid; Microscopy, Confocal; Neurons; Piperidines; Pregnancy; Rats; Receptors, N-Methyl-D-Aspartate; tau Proteins | 1996 |
Differential action of NMDA antagonists on cholinergic neurotoxicity produced by N-methyl-D-aspartate and quinolinic acid.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Brain; Choline O-Acetyltransferase; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Antagonism; Excitatory Amino Acid Antagonists; Kynurenic Acid; Male; N-Methylaspartate; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1996 |
Reduction in the mechanonociceptive response by intrathecal administration of glycine and related compounds.
Topics: Animals; Cerebrospinal Fluid; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glycine; Glycine Agents; Injections, Spinal; Kynurenic Acid; Male; Mechanoreceptors; Neuralgia; Nociceptors; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Strychnine; Transcutaneous Electric Nerve Stimulation | 1996 |
Pharmacological characterization of inward current evoked by N-methyl-D-aspartate in dopamine neurons in the rat brain slice.
Topics: Animals; Dizocilpine Maleate; Excitatory Amino Acid Agonists; In Vitro Techniques; Kynurenic Acid; Magnesium; Male; Membrane Potentials; N-Methylaspartate; Phencyclidine; Piperidines; Rats; Rats, Sprague-Dawley; Sodium; Spermine; Substantia Nigra; Ventral Tegmental Area | 1996 |
Pharmacological properties of acquired excitotoxicity in Chinese hamster ovary cells transfected with N-methyl-D-aspartate receptor subunits.
Topics: Animals; Calcium; Cell Survival; CHO Cells; Cricetinae; Dizocilpine Maleate; Kynurenic Acid; L-Lactate Dehydrogenase; Luciferases; Pipecolic Acids; Piperidines; Receptors, N-Methyl-D-Aspartate; Transfection | 1996 |
NMDA receptor dependence of the input specific NMDA receptor-independent LTP in the hippocampal CA1 region.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Calcium Channel Blockers; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Guinea Pigs; Hippocampus; In Vitro Techniques; Kynurenic Acid; Long-Term Potentiation; Male; Nifedipine; Receptors, N-Methyl-D-Aspartate | 1997 |
Role of the NMDA receptor complex in DMCM-induced seizure in mice.
Topics: Animals; Carbolines; Cerebral Ventricles; Convulsants; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Infusions, Intravenous; Injections, Intraventricular; Injections, Spinal; Kynurenic Acid; Male; Mice; Mice, Inbred Strains; Phencyclidine; Piperidines; Receptors, N-Methyl-D-Aspartate; Seizures; Spinal Cord | 1997 |
Recovery of decreased seizure threshold for pentylenetetrazole during diazepam withdrawal by NMDA receptor antagonists.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Disease Models, Animal; Dizocilpine Maleate; Drug Interactions; Excitatory Amino Acid Antagonists; Infusions, Intravenous; Injections, Intraperitoneal; Injections, Subcutaneous; Kynurenic Acid; Male; Mice; Neuroprotective Agents; Pentylenetetrazole; Piperidines; Receptors, N-Methyl-D-Aspartate; Seizures; Substance Withdrawal Syndrome | 1997 |
Neurotoxicity associated with dual actions of homocysteine at the N-methyl-D-aspartate receptor.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adult; Animals; Cells, Cultured; Cerebral Cortex; Child; Dizocilpine Maleate; Embryo, Mammalian; Evoked Potentials; Glycine; Homocysteine; Humans; Kinetics; Kynurenic Acid; N-Methylaspartate; Neurons; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1997 |
Comparing long-term depression with pharmacologically induced synaptic attenuations in young rat hippocampi.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Dizocilpine Maleate; Evoked Potentials; Excitatory Amino Acid Antagonists; Hippocampus; Kynurenic Acid; Male; Neuronal Plasticity; Neurotransmitter Agents; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Receptors, Presynaptic; Synapses | 1997 |
EMD 95885, a new eliprodil analogue with higher affinity for the N-methyl-D-aspartate (NMDA) receptor.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding, Competitive; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Kainic Acid; Kynurenic Acid; Male; Piperidines; Radioligand Assay; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1997 |
No effect of glutamate on metabolic disturbances in hippocampal slices of mature fetal guinea pigs after transient in vitro ischemia.
Topics: Adenosine Triphosphate; Animals; Dizocilpine Maleate; Energy Metabolism; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Guinea Pigs; Hippocampus; Ischemic Attack, Transient; Kinetics; Kynurenic Acid; Nerve Tissue Proteins; Pregnancy | 1997 |
Selective depression of the spinal polysynaptic reflex by the NMDA receptor antagonists in an isolated spinal cord in vitro.
Topics: Animals; Depression, Chemical; Dizocilpine Maleate; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; In Vitro Techniques; Kynurenic Acid; Male; Piperazines; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reflex; Reflex, Monosynaptic; Serine; Spinal Cord; Spinal Nerve Roots; Strychnine; Valine | 1997 |
NMDA receptor involvement in neuroplastic changes induced by neonatal capsaicin treatment in trigeminal nociceptive neurons.
Topics: Animals; Animals, Newborn; Capsaicin; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Functional Laterality; Hindlimb; Injections, Spinal; Kynurenic Acid; Male; Medulla Oblongata; Neuronal Plasticity; Neurons; Nociceptors; Pain; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Trigeminal Nerve | 1997 |
Acute effects of various GABA receptor agonists and glutamate antagonists on focal hippocampal seizures in freely moving rats elicited by low-frequency stimulation.
Topics: Animals; Anticonvulsants; Ataxia; Carbamazepine; Diazepam; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; GABA Agonists; Hippocampus; Kynurenic Acid; Male; Muscimol; Pipecolic Acids; Quinoxalines; Rats; Rats, Wistar; Seizures | 1998 |
Effect of nitric oxide donors on endogenous dopamine release from rat striatal slices. II: The role of voltage-dependent sodium channels, calcium channel activation, reverse transport mechanism, guanylate cyclase and endogenous glutamate.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Calcium Channel Blockers; Corpus Striatum; Dizocilpine Maleate; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Guanylate Cyclase; Hydroxylamine; In Vitro Techniques; Kynurenic Acid; Male; Methylene Blue; Nitric Oxide; Nitroprusside; Nomifensine; omega-Conotoxin GVIA; Peptides; Rats; Rats, Sprague-Dawley; Sodium Channels; Tetrodotoxin; Vasodilator Agents; Verapamil | 1997 |
2,3-Dihydro-6,7-dichloro-pyrido[2,3-b]pyrazine-8-oxide as selective glycine antagonist with in vivo activity.
Topics: Animals; Avoidance Learning; Binding Sites; Cyclic N-Oxides; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glycine; Kynurenic Acid; Mice; Motor Activity; N-Methylaspartate; Neuroprotective Agents; Pyrazines; Rats; Receptors, N-Methyl-D-Aspartate; Seizures; Stereotyped Behavior; Strychnine | 1997 |
The ventral pallidum mediates disruption of prepulse inhibition of the acoustic startle response induced by dopamine agonists, but not by NMDA antagonists.
Topics: Acoustic Stimulation; Animals; Apomorphine; Dizocilpine Maleate; Dopamine Agonists; Excitatory Amino Acid Antagonists; Globus Pallidus; Injections; Kynurenic Acid; Male; N-Methylaspartate; Neural Inhibition; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Reflex, Startle | 1998 |
Chronic dosing with 1-aminocyclopropanecarboxylic acid, a glycine partial agonist, modulates NMDA inhibition of muscarinic-coupled PI hydrolysis in rat cortical slices.
Topics: 2-Amino-5-phosphonovalerate; Animals; Carbachol; Cerebral Cortex; Cycloleucine; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Hydrolysis; In Vitro Techniques; Inositol; Kynurenic Acid; Male; Muscarinic Agonists; N-Methylaspartate; Phosphatidylinositols; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1998 |
Complex polyamine effects on [3H]MDL 105,519 binding to the NMDA receptor glycine site.
Topics: Aminoquinolines; Animals; Binding Sites; Binding, Competitive; Brain; Cell Membrane; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glycine; Indoles; Kynurenic Acid; Polyamines; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine; Tritium | 1998 |
The role of striatal glutamate receptors in models of Parkinson's disease.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Dizocilpine Maleate; Electromyography; Excitatory Amino Acid Antagonists; Haloperidol; Kynurenic Acid; Parkinson Disease; Quinolones; Rats; Receptors, N-Methyl-D-Aspartate; Reserpine | 1998 |
Ferrous iron modulates quinolinate-mediated [3H]MK-801 binding to rat brain synaptic membranes in the presence of glycine and spermidine.
Topics: 2-Amino-5-phosphonovalerate; Allosteric Regulation; Animals; Binding Sites; Brain; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Ferrous Compounds; Glutamic Acid; Glycine; Inhibitory Concentration 50; Kynurenic Acid; Male; Quinolinic Acid; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermidine; Synaptic Membranes | 1999 |
N-methyl-D-asparate receptor antagonists abolish the maintenance phase of self-sustaining status epilepticus in rat.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Anticonvulsants; Disease Models, Animal; Dizocilpine Maleate; Electric Stimulation; Excitatory Amino Acid Antagonists; Hippocampus; Ketamine; Kynurenic Acid; Male; Perforant Pathway; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Status Epilepticus | 1999 |
Na+, K+ and Ca2+ antagonize the glutamate- and glycine-induced decrease of [3H]MK-801 binding observed in the presence of Mg2+ at low pH.
Topics: Animals; Calcium; Cations; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamates; Glycine; Hydrogen-Ion Concentration; Kynurenic Acid; Magnesium; Male; Potassium; Protein Binding; Quinolones; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sodium | 1999 |
The non-NMDA glutamate receptor antagonists 6-cyano-7-nitroquinoxaline-2,3-dione and 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxaline, but not NMDA antagonists, block the intrastriatal neurotoxic effect of MPP+.
Topics: 1-Methyl-4-phenylpyridinium; 3,4-Dihydroxyphenylacetic Acid; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Corpus Striatum; Dizocilpine Maleate; Dopamine; Dopamine Agents; Excitatory Amino Acid Antagonists; Female; Homovanillic Acid; Kynurenic Acid; Microinjections; Neuroprotective Agents; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Tyrosine 3-Monooxygenase | 1999 |
Dynorphin A (1-13) neurotoxicity in vitro: opioid and non-opioid mechanisms in mouse spinal cord neurons.
Topics: Analgesics, Opioid; Animals; Calcium; Cell Survival; Dizocilpine Maleate; Dynorphins; Embryo, Mammalian; Kynurenic Acid; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Neurotoxins; Peptide Fragments; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Valine | 1999 |
Enhancement of NMDA-induced current by the putative NR2B selective antagonist ifenprodil.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Kynurenic Acid; Male; Membrane Potentials; N-Methylaspartate; Organ Culture Techniques; Piperidines; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermine | 2000 |
[Inefficacy of N-methyl-D-aspartate receptor complex antagonists on behavioral and histologic consequences of global cerebral ischemia in rats].
Topics: Animals; Brain; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Ischemic Attack, Transient; Kynurenic Acid; Male; Motor Activity; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Time Factors | 2000 |
Glycine(B) receptor antagonists and partial agonists prevent memory deficits in inhibitory avoidance learning.
Topics: Animals; Avoidance Learning; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Inhibition, Psychological; Kynurenic Acid; Male; Memory Disorders; Mice; Muscarinic Antagonists; Pyrrolidinones; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Retention, Psychology; Scopolamine | 2000 |
The HIV-1 coat protein gp120 and some of its fragments potently activate native cerebral NMDA receptors mediating neuropeptide release.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cerebral Cortex; Cholecystokinin; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; HIV Envelope Protein gp120; HIV-1; Indoles; Kynurenic Acid; Male; Maleimides; Neurons; Nitroarginine; Peptide Fragments; Pipecolic Acids; Piperazines; Piperidines; Potassium; Protein Structure, Tertiary; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Somatostatin; Synaptic Transmission; Synaptosomes; Zinc | 2000 |
Excitation of nigral dopamine neurons by the GABA(A) receptor agonist muscimol is mediated via release of glutamate.
Topics: Animals; Butyrates; Dizocilpine Maleate; Dopamine; Dose-Response Relationship, Drug; Evoked Potentials; GABA Agonists; GABA-A Receptor Antagonists; Glutamic Acid; Kynurenic Acid; Male; Membrane Potentials; Muscimol; Neurons; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Substantia Nigra | 2000 |
Effects of reboxetine and sertraline treatments alone and in combination on the binding properties of cortical NMDA and beta1-adrenergic receptors in an animal model of depression.
Topics: Adrenergic beta-Antagonists; Adrenergic Uptake Inhibitors; Animals; Cerebral Cortex; Depressive Disorder; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Kynurenic Acid; Male; Morpholines; Neurons; Norepinephrine; Propanolamines; Rats; Rats, Sprague-Dawley; Reboxetine; Receptors, Adrenergic, beta-1; Receptors, N-Methyl-D-Aspartate; Serotonin; Sertraline | 2000 |
Attenuation of morphine dependence and withdrawal by glycine B site antagonists in rats.
Topics: Animals; Behavior, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Implants; Excitatory Amino Acid Antagonists; Glycine Agents; Kynurenic Acid; Male; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Narcotics; Quinolones; Rats; Rats, Wistar; Receptors, Glycine; Substance Withdrawal Syndrome | 2001 |
Optical recording of spreading depression in rat neocortical slices.
Topics: Animals; Anti-Ulcer Agents; Carbenoxolone; Cortical Spreading Depression; Dizocilpine Maleate; Electronic Data Processing; Electrophysiology; Gap Junctions; Kynurenic Acid; Lighting; Male; Neocortex; Neurons; Octanols; Organ Culture Techniques; Potassium Chloride; Rats; Rats, Wistar; Receptors, Glutamate | 2001 |
Role of spinal NMDA receptors, protein kinase C and nitric oxide synthase in the hyperalgesia induced by magnesium deficiency in rats.
Topics: 2-Amino-5-phosphonovalerate; Alkaloids; Analgesics; Animals; Benzophenanthridines; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hyperalgesia; Indazoles; Injections, Spinal; Kynurenic Acid; Magnesium Sulfate; Male; Neurons; Nitric Oxide Synthase; Pain Measurement; Phenanthridines; Protein Kinase C; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spine | 2001 |
Vasodilatory N-methyl-D-aspartate receptors are constitutively expressed in rat kidney.
Topics: Analysis of Variance; Animals; Dizocilpine Maleate; DNA, Complementary; Glomerular Filtration Rate; Glycine; Hemodynamics; Immunohistochemistry; Kidney Cortex; Kynurenic Acid; Male; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Renal Circulation; Reverse Transcriptase Polymerase Chain Reaction | 2002 |
Increased phasic activity of dopaminergic neurones in the rat ventral tegmental area following pharmacologically elevated levels of endogenous kynurenic acid.
Topics: Action Potentials; Animals; Antimetabolites; Butyrates; Cycloserine; Dizocilpine Maleate; Dopamine; Excitatory Amino Acid Antagonists; Kynurenic Acid; Male; Neurons; Rats; Rats, Sprague-Dawley; Schizophrenia; Ventral Tegmental Area | 2002 |
Synergistic versus antagonistic actions of glutamate and glutathione: the role of excitotoxicity and oxidative stress in neuronal disease.
Topics: Animals; Behavior, Animal; Cerebral Cortex; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Flour; Glutamic Acid; Glutathione; Kynurenic Acid; L-Lactate Dehydrogenase; Male; Methionine Sulfoximine; Mice; Mice, Inbred Strains; N-Methylaspartate; Nervous System Diseases; Oxidative Stress; Plants, Toxic; Rats; Rats, Sprague-Dawley; Sitosterols | 2002 |
In vitro and in vivo antagonistic activities of SM-31900 for the NMDA receptor glycine-binding site.
Topics: Aminoquinolines; Animals; Binding, Competitive; Brain; Cells, Cultured; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Fetus; Glutamic Acid; Indoles; Kynurenic Acid; Male; Neurons; Neuroprotective Agents; Neurotoxins; Radioligand Assay; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Seizures | 2002 |
Intrathecally administered big dynorphin, a prodynorphin-derived peptide, produces nociceptive behavior through an N-methyl-D-aspartate receptor mechanism.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Analgesics, Opioid; Animals; Behavior, Animal; Dizocilpine Maleate; Dynorphins; Endorphins; Enkephalins; Excitatory Amino Acid Antagonists; Injections, Spinal; Kynurenic Acid; Male; Mice; Morphine; Neurokinin A; Nociceptors; Peptide Fragments; Piperidines; Protein Precursors; Receptors, N-Methyl-D-Aspartate; Receptors, Tachykinin; Substance P | 2002 |
Differential alterations in the expression of NMDA receptor subunits following chronic ethanol treatment in primary cultures of rat cortical and hippocampal neurones.
Topics: Animals; Animals, Newborn; Cells, Cultured; Cerebral Cortex; Culture Media, Serum-Free; Dizocilpine Maleate; Ethanol; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Hippocampus; Kynurenic Acid; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Piperidines; Protein Subunits; Rats; Receptors, N-Methyl-D-Aspartate; RNA Splicing | 2003 |
Behavioral effects of NMDA receptor agonists and antagonists in combination with nitric oxide-related compounds.
Topics: 2-Amino-5-phosphonovalerate; Animals; Arginine; Conditioning, Operant; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Gallic Acid; Guanidines; Indazoles; Injections, Intraperitoneal; Kynurenic Acid; Molsidomine; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitroprusside; Phencyclidine; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2003 |
Kynurenic acid prevented social recognition deficits induced by MK-801 in rats.
Topics: Animals; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Kynurenic Acid; Male; Memory Disorders; Olfactory Pathways; Rats; Rats, Wistar; Recognition, Psychology; Social Behavior | 2003 |
Differential presynaptic modulation of excitatory and inhibitory autaptic currents in cultured hippocampal neurons.
Topics: Animals; Cells, Cultured; Dizocilpine Maleate; Hippocampus; Kynurenic Acid; Neural Inhibition; Neurons; Presynaptic Terminals; Rats; Synaptic Transmission | 2004 |
Putative NMDA receptors in Hydra: a biochemical and functional study.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Binding Sites; Cell Membrane; Concanavalin A; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Feeding Behavior; Glutamic Acid; Glutathione; Glycine; Hydra; Kynurenic Acid; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Serine; Strychnine | 2004 |
Spontaneous alternation behaviour in rats: kynurenic acid attenuated deficits induced by MK-801.
Topics: Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Exploratory Behavior; Glutamic Acid; Kynurenic Acid; Male; Motor Activity; Nootropic Agents; Piracetam; Rats; Rats, Wistar | 2006 |
Activation of the caspase 8 pathway mediates seizure-induced cell death in cultured hippocampal neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Caspase 8; Caspase 9; Caspases; Cell Death; Cells, Cultured; Dizocilpine Maleate; DNA Damage; Excitatory Amino Acid Antagonists; Hippocampus; Kynurenic Acid; L-Lactate Dehydrogenase; Neurons; Rats; Rats, Sprague-Dawley; Seizures | 2006 |
Glycine binding sites of presynaptic NMDA receptors may tonically regulate glutamate release in the rat visual cortex.
Topics: Animals; Binding Sites; Binding, Competitive; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Glycine; Kynurenic Acid; Organ Culture Techniques; Presynaptic Terminals; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Visual Cortex | 2007 |
Intrathecally administered D-cycloserine produces nociceptive behavior through the activation of N-methyl-D-aspartate receptor ion-channel complex acting on the glycine recognition site.
Topics: 2-Amino-5-phosphonovalerate; Agmatine; Animals; Cycloserine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Injections, Spinal; Ion Channels; Kynurenic Acid; Mice; Morphine; Neurokinin A; Nociceptors; Pain; Peptide Fragments; Piperidines; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Tachykinin; Substance P | 2007 |
Comparative study of NMDA and AMPA/kainate receptors involved in cardiovascular inhibition produced by imidazoline-like drugs in anaesthetized rats.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Anesthesia; Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Dizocilpine Maleate; Drug Interactions; Excitatory Amino Acid Antagonists; Heart Rate; Imidazoles; Imidazoline Receptors; Injections, Intraventricular; Kynurenic Acid; Male; Medulla Oblongata; Microinjections; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Drug; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate | 2007 |
Tonic facilitation of glutamate release by glycine binding sites on presynaptic NR2B-containing NMDA autoreceptors in the rat visual cortex.
Topics: Animals; Animals, Newborn; Binding Sites; Dizocilpine Maleate; Drug Interactions; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Glycine; In Vitro Techniques; Kynurenic Acid; Patch-Clamp Techniques; Phenols; Piperidines; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Visual Cortex | 2008 |
N-methyl-D-aspartate receptors and amnesia in mice with depression-like state.
Topics: Amnesia; Analysis of Variance; Animals; Avoidance Learning; Behavior, Animal; Cycloserine; Depression; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Kynurenic Acid; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Receptors, Amino Acid | 2007 |
Glutamate modulation of antinociception, but not tolerance, produced by morphine microinjection into the periaqueductal gray of the rat.
Topics: Analgesia; Analgesics, Opioid; Analysis of Variance; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Excitatory Amino Acid Antagonists; Glutamic Acid; Hot Temperature; Kynurenic Acid; Male; Microinjections; Morphine; Pain; Pain Measurement; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Opioid, mu; Staining and Labeling | 2009 |
Parabrachial complex glutamate receptors modulate the cardiorespiratory response evoked from hypothalamic defense area.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Blood Pressure; Cardiovascular Physiological Phenomena; Dizocilpine Maleate; Electric Stimulation; Heart Rate; Hypothalamus; Kynurenic Acid; Male; Microinjections; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Respiration; Tachycardia | 2012 |
Probing the modulation of acute ethanol intoxication by pharmacological manipulation of the NMDAR glycine co-agonist site.
Topics: Alcoholic Intoxication; Animals; Ataxia; Cycloserine; Disease Models, Animal; Disks Large Homolog 4 Protein; Dizocilpine Maleate; Drug Therapy, Combination; Glycine Plasma Membrane Transport Proteins; Guanylate Kinases; Hypothermia; Kynurenic Acid; Magnesium; Male; Membrane Proteins; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Quinolones; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Reflex, Righting; Sarcosine; Serine | 2013 |
Changes in GABAergic inputs in the paraventricular nucleus maintain sympathetic vasomotor tone in chronic heart failure.
Topics: Animals; Autoradiography; Blood Pressure; Disease Models, Animal; Dizocilpine Maleate; Echocardiography; Excitatory Amino Acid Antagonists; GABA-A Receptor Agonists; GABAergic Neurons; Heart Failure; Heart Rate; Heart Ventricles; Kidney; Kynurenic Acid; Ligation; Male; Microinjections; Muscimol; Paraventricular Hypothalamic Nucleus; Phloroglucinol; Rats; Rats, Wistar; Splanchnic Nerves; Terpenes; Tritium | 2012 |
Metabotropic NMDA receptor function is required for NMDA receptor-dependent long-term depression.
Topics: Animals; Calcium Signaling; Chelating Agents; Dizocilpine Maleate; Egtazic Acid; Hippocampus; Kynurenic Acid; Long-Term Synaptic Depression; Neuronal Plasticity; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Tissue Culture Techniques | 2013 |
Unexpected effects of peripherally administered kynurenic acid on cortical spreading depression and related blood-brain barrier permeability.
Topics: Animals; Blood-Brain Barrier; Cortical Spreading Depression; Dizocilpine Maleate; Electroencephalography; Excitatory Amino Acid Antagonists; Kynurenic Acid; Male; Microscopy, Fluorescence; Migraine Disorders; Permeability; Rats; Rats, Wistar | 2013 |
Effect of maternal immune activation on the kynurenine pathway in preadolescent rat offspring and on MK801-induced hyperlocomotion in adulthood: amelioration by COX-2 inhibition.
Topics: Animals; Brain; Celecoxib; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Dizocilpine Maleate; Female; Gestational Age; Hyperkinesis; Kynurenic Acid; Kynurenine; Male; Picolinic Acids; Poly I-C; Pregnancy; Prenatal Exposure Delayed Effects; Pyrazoles; Quinolinic Acid; Random Allocation; Rats; Rats, Wistar; Schizophrenia; Sexual Maturation; Sulfonamides; Tryptophan | 2014 |
A Metabotropic-Like Flux-Independent NMDA Receptor Regulates Ca2+ Exit from Endoplasmic Reticulum and Mitochondrial Membrane Potential in Cultured Astrocytes.
Topics: 2-Amino-5-phosphonovalerate; Aniline Compounds; Animals; Astrocytes; Benzimidazoles; Calcium; Calcium Channel Blockers; Carbocyanines; Cells, Cultured; Dizocilpine Maleate; Endoplasmic Reticulum; Inositol 1,4,5-Trisphosphate Receptors; Ions; Kynurenic Acid; Membrane Potential, Mitochondrial; N-Methylaspartate; Protein Subunits; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; RNA, Small Interfering; Xanthenes | 2015 |
Characterization of the Effects of L-4-Chlorokynurenine on Nociception in Rodents.
Topics: Amines; Analgesics; Animals; Brain; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Kynurenic Acid; Kynurenine; Male; Prodrugs; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 2017 |
Kynurenic acid and its analogue can alter the opioid receptor G-protein signaling after acute treatment via NMDA receptor in rat cortex and striatum.
Topics: Animals; Cell Membrane; Central Nervous System Agents; Cerebral Cortex; Chromatography, High Pressure Liquid; Corpus Striatum; Dizocilpine Maleate; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Kynurenic Acid; Male; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Tissue Culture Techniques | 2017 |
Kynurenic Acid Prevents Cytoskeletal Disorganization Induced by Quinolinic Acid in Mixed Cultures of Rat Striatum.
Topics: Animals; Antioxidants; Astrocytes; Cell Communication; Cells, Cultured; Corpus Striatum; Cytoskeleton; Dizocilpine Maleate; Gap Junctions; Kynurenic Acid; Microglia; Models, Biological; N-Methylaspartate; Neurons; Oxidative Stress; Quinolinic Acid; Rats, Wistar; Signal Transduction; Tumor Necrosis Factor-alpha | 2018 |
Glutamate receptors of the A5 region modulate cardiovascular responses evoked from the dorsomedial hypothalamic nucleus and perifornical area.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Blood Pressure; Cardiovascular Physiological Phenomena; Dizocilpine Maleate; Dorsomedial Hypothalamic Nucleus; Electric Stimulation; Excitatory Amino Acid Antagonists; Fornix, Brain; Glycine; Heart Rate; Kynurenic Acid; Male; Microinjections; Rats; Receptors, Glutamate; Respiratory Rate; Tachycardia | 2018 |
Acute and subchronic PCP attenuate D2 autoreceptor signaling in substantia nigra dopamine neurons.
Topics: Action Potentials; Animals; Dizocilpine Maleate; Dopamine; Dopaminergic Neurons; Dose-Response Relationship, Drug; Drug Administration Schedule; Electric Stimulation; Excitatory Amino Acid Antagonists; In Vitro Techniques; Iontophoresis; Kynurenic Acid; Male; Mice; Patch-Clamp Techniques; Phencyclidine; Receptors, Dopamine D2; Signal Transduction; Substantia Nigra | 2019 |