kynurenic acid and alanine

kynurenic acid has been researched along with alanine in 23 studies

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19902 (8.70)18.7374
1990's15 (65.22)18.2507
2000's5 (21.74)29.6817
2010's1 (4.35)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Gordon, FJ; Pawloski-Dahm, C1
Alesiani, M; Davolio, P; Lombardi, G; Moroni, F; Pellicciari, R; Russi, P1
Brodie, MJ; Connick, JH; Heywood, GC; Sills, GJ; Stone, TW; Thompson, GG1
Bradford, HF; Croucher, MJ1
Gallo-Mezo, MA; Moneti, G; Moroni, F; Pellicciari, R; Russi, P1
Benveniste, M; Mayer, ML; Mienville, JM; Sernagor, E1
Curzon, G; Green, AR1
Carpenedo, R; Chiarugi, A; Mattoli, L; Molina, MT; Moroni, F; Pellicciari, R1
Carlà, V; Carpenedo, R; Chiarugi, A; Lombardi, G; Mattoli, L; Moroni, F; Pellicciari, R; Russi, P1
Carpenedo, R; Chiarugi, A; Costantino, G; Mahmoud, MR; Mattoli, L; Moroni, F; Natalini, B; Pellicciari, R; Sadeghpour, BM1
Akhondzadeh, S; Stone, TW1
Han, Y; Slaughter, MM; Zhang, J1
Beninger, RJ; Boegman, RJ; Jhamandas, K; Miranda, AF1
Beninger, RJ; Boegman, RJ; Harris, CA; Jhamandas, K; Miranda, AF; Tanguay, JJ1
Beninger, RJ; Boegman, RJ; Jhamandas, K; Miranda, AF; Sutton, MA1
Ceresoli-Borroni, G; Guidetti, P; Hodgkins, PS; Poeggeler, B; Rassoulpour, A; Schwarcz, R; Wu, HQ1
Carpenedo, R; Meli, E; Moroni, F; Pellegrini-Giampietro, DE; Peruginelli, F1
HAYAISHI, O; KUNO, S; TANIUCHI, H; TASHIRO, M1
Johnson, MS; Moretti, L; Pentikäinen, OT; Settimo, L1
Barth, A; Barth, L; Newell, DW; Nguyen, LB1
Smothers, CT; Woodward, JJ1
Kussius, CL; Popescu, GK1
Cline, MA; Kadomoto, Y; Khan, MSI; Makino, R; Tachibana, T1

Trials

1 trial(s) available for kynurenic acid and alanine

ArticleYear
Effect of l-tryptophan and its metabolites on food passage from the crop in chicks.
    Domestic animal endocrinology, 2018, Volume: 64

    Topics: Administration, Oral; Alanine; Animals; Asparagine; Chickens; Crop, Avian; Gastrointestinal Motility; Glycine; Kynurenic Acid; Male; Quinolinic Acid; Tryptophan

2018

Other Studies

22 other study(ies) available for kynurenic acid and alanine

ArticleYear
Evidence for a kynurenate-insensitive glutamate receptor in nucleus tractus solitarii.
    The American journal of physiology, 1992, Volume: 262, Issue:5 Pt 2

    Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aorta; Blood Pressure; Cycloleucine; Electric Stimulation; Female; Heart Rate; Ibotenic Acid; Kynurenic Acid; Medulla Oblongata; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, Glutamate; Receptors, Neurotransmitter

1992
Nicotinylalanine increases the formation of kynurenic acid in the brain and antagonizes convulsions.
    Journal of neurochemistry, 1992, Volume: 59, Issue:6

    Topics: Alanine; Animals; Anticonvulsants; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Extracellular Matrix; Hippocampus; Kidney; Kynurenic Acid; Liver; Male; Niacin; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Serine; Tryptophan

1992
Nicotinylalanine increases cerebral kynurenic acid content and has anticonvulsant activity.
    General pharmacology, 1992, Volume: 23, Issue:2

    Topics: Alanine; Animals; Anticonvulsants; Brain Chemistry; Electroshock; In Vitro Techniques; Kidney; Kynurenic Acid; Liver; Male; Mice; Mice, Inbred Strains; Niacin; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures; Tryptophan

1992
The influence of strychnine-insensitive glycine receptor agonists and antagonists on generalized seizure thresholds.
    Brain research, 1991, Mar-08, Volume: 543, Issue:1

    Topics: Alanine; Amygdala; Animals; Glycine; Kindling, Neurologic; Kynurenic Acid; Male; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures; Serine; Strychnine

1991
Modulation of quinolinic and kynurenic acid content in the rat brain: effects of endotoxins and nicotinylalanine.
    Journal of neurochemistry, 1991, Volume: 57, Issue:5

    Topics: Alanine; Animals; Brain; Endotoxins; Escherichia coli; Gas Chromatography-Mass Spectrometry; Kidney; Kynurenic Acid; Lipopolysaccharides; Liver; Male; Models, Neurological; Niacin; Organ Specificity; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains

1991
Concentration-jump experiments with NMDA antagonists in mouse cultured hippocampal neurons.
    Journal of neurophysiology, 1990, Volume: 63, Issue:6

    Topics: 2-Amino-5-phosphonovalerate; Alanine; Animals; Aspartic Acid; Cells, Cultured; Glycine; Hippocampus; Kynurenic Acid; Mice; N-Methylaspartate; Neurons; Osmolar Concentration; Piperazines

1990
The effect of tryptophan metabolites on brain 5-hydroxytryptamine metabolism.
    Biochemical pharmacology, 1970, Volume: 19, Issue:6

    Topics: Alanine; Allopurinol; Amino Acids; Animals; Brain; Brain Chemistry; Carbon Isotopes; Carboxy-Lyases; Histamine; Kynurenic Acid; Kynurenine; Male; Methanol; Methyldopa; Mixed Function Oxygenases; Niacinamide; Nicotinic Acids; Nitroglycerin; ortho-Aminobenzoates; Phenylalanine; Phenylbutyrates; Picolinic Acids; Pyridines; Pyridoxal Phosphate; Pyridoxine; Rats; Serotonin; Sulfuric Acids; Time Factors; Tryptophan; Tryptophan Oxygenase; Xanthurenates

1970
Comparison of the neurochemical and behavioral effects resulting from the inhibition of kynurenine hydroxylase and/or kynureninase.
    Journal of neurochemistry, 1995, Volume: 65, Issue:3

    Topics: Alanine; Animals; Anticonvulsants; Behavior, Animal; Drug Interactions; Extracellular Space; Hydrolases; Hypnotics and Sedatives; Kinetics; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Male; Mixed Function Oxygenases; Quinolinic Acid; Rats; Rats, Wistar

1995
Inhibitors of kynurenine hydroxylase and kynureninase increase cerebral formation of kynurenate and have sedative and anticonvulsant activities.
    Neuroscience, 1994, Volume: 61, Issue:2

    Topics: Alanine; Animals; Anticonvulsants; Brain Chemistry; Electroshock; Excitatory Amino Acid Antagonists; Hydrolases; Hypnotics and Sedatives; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Male; Mixed Function Oxygenases; Motor Activity; Neuroglia; Niacin; ortho-Aminobenzoates; Quinolinic Acid; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate

1994
Modulation of the kynurenine pathway in search for new neuroprotective agents. Synthesis and preliminary evaluation of (m-nitrobenzoyl)alanine, a potent inhibitor of kynurenine-3-hydroxylase.
    Journal of medicinal chemistry, 1994, Mar-04, Volume: 37, Issue:5

    Topics: Alanine; Animals; Anticonvulsants; Binding, Competitive; Brain; Hippocampus; Hydrolases; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Liver; Mixed Function Oxygenases; Models, Molecular; Molecular Structure; Motor Activity; Rats; Seizures; Tryptophan

1994
Glutamate-independent long term depression in rat hippocampus by activation GABAA receptors.
    Life sciences, 1996, Volume: 58, Issue:13

    Topics: 2-Amino-5-phosphonovalerate; Adenosine; Alanine; Animals; Cycloleucine; Electric Stimulation; Excitatory Amino Acid Antagonists; GABA-A Receptor Antagonists; Glutamic Acid; Hippocampus; In Vitro Techniques; Kinetics; Kynurenic Acid; Male; Muscimol; Neuronal Plasticity; Neurotoxins; Pyramidal Cells; Rats; Rats, Wistar; Receptors, GABA-A

1996
Partition of transient and sustained inhibitory glycinergic input to retinal ganglion cells.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997, May-15, Volume: 17, Issue:10

    Topics: Alanine; Ambystoma; Animals; Electrophysiology; Excitatory Amino Acid Antagonists; Glycine; Glycine Agents; Kynurenic Acid; Receptors, Glycine; Retinal Ganglion Cells; Serine; Strychnine; Synaptic Transmission; Taurine

1997
Protection against quinolinic acid-mediated excitotoxicity in nigrostriatal dopaminergic neurons by endogenous kynurenic acid.
    Neuroscience, 1997, Volume: 78, Issue:4

    Topics: Alanine; Animals; Corpus Striatum; Dopamine; Drug Combinations; Injections, Intraventricular; Kynurenic Acid; Kynurenine; Male; N-Methylaspartate; Neurons; Neurotoxins; Niacin; Probenecid; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Substantia Nigra; Tyrosine 3-Monooxygenase

1997
Modulation of striatal quinolinate neurotoxicity by elevation of endogenous brain kynurenic acid.
    British journal of pharmacology, 1998, Volume: 124, Issue:2

    Topics: Alanine; Animals; Anticonvulsants; Corpus Striatum; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Amino Acid Antagonists; GABA Antagonists; Huntington Disease; Injections, Intraventricular; Kynurenic Acid; Kynurenine; Male; NADP; Neurons, Afferent; Niacin; Probenecid; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate

1998
Quinolinic acid lesion of the nigrostriatal pathway: effect on turning behaviour and protection by elevation of endogenous kynurenic acid in Rattus norvegicus.
    Neuroscience letters, 1999, Mar-05, Volume: 262, Issue:2

    Topics: Alanine; Animals; Corpus Striatum; Excitatory Amino Acid Antagonists; Hydrolases; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Male; Mixed Function Oxygenases; Motor Activity; Neurons; Neuroprotective Agents; Niacin; Parkinson Disease, Secondary; Probenecid; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Substantia Nigra; Tyrosine 3-Monooxygenase; Up-Regulation

1999
Modulation and function of kynurenic acid in the immature rat brain.
    Advances in experimental medicine and biology, 1999, Volume: 467

    Topics: 2-Amino-5-phosphonovalerate; Aging; Alanine; Animals; Brain; Dextroamphetamine; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glucose; Kynurenic Acid; Kynurenine 3-Monooxygenase; Male; Microdialysis; Mixed Function Oxygenases; N-Methylaspartate; Neurons; Pyruvates; Rats; Rats, Sprague-Dawley

1999
Kynurenine 3-mono-oxygenase inhibitors attenuate post-ischemic neuronal death in organotypic hippocampal slice cultures.
    Journal of neurochemistry, 2002, Volume: 82, Issue:6

    Topics: Alanine; Animals; Brain Ischemia; Cell Death; Cell Hypoxia; Culture Media, Conditioned; Enzyme Inhibitors; Glucose; Hippocampus; In Vitro Techniques; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Mixed Function Oxygenases; Neurons; Neuroprotective Agents; Pyramidal Cells; Quinolinic Acid; Rats; Sulfonamides; Thiazoles

2002
Studies on the metabolism of kynurenic acid. I. The formation of L-glutamic acid, D- and L-alanine, and acetic acid from kynurenic acid by Pseudomonas extracts.
    The Journal of biological chemistry, 1961, Volume: 236

    Topics: Acetates; Acetic Acid; Alanine; Glutamates; Glutamic Acid; Kynurenic Acid; Pseudomonas

1961
Model structures of the N-methyl-D-aspartate receptor subunit NR1 explain the molecular recognition of agonist and antagonist ligands.
    Journal of structural biology, 2004, Volume: 145, Issue:3

    Topics: Alanine; Amino Acid Sequence; Animals; Bacterial Proteins; Binding Sites; Crystallography, X-Ray; Cycloserine; Databases as Topic; Escherichia coli; Excitatory Amino Acid Antagonists; Glycine; Humans; Hydrogen Bonding; Indoles; Kynurenic Acid; Ligands; Mice; Models, Chemical; Models, Molecular; Molecular Sequence Data; Potassium Channels; Proline; Protein Binding; Protein Conformation; Protein Isoforms; Protein Structure, Tertiary; Rats; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Sequence Homology, Amino Acid; Serine; Threonine; Tryptophan; Water

2004
Glycine-induced neurotoxicity in organotypic hippocampal slice cultures.
    Experimental brain research, 2005, Volume: 161, Issue:3

    Topics: Alanine; Animals; Animals, Newborn; Brain Ischemia; Dose-Response Relationship, Drug; Drug Resistance; Glutamic Acid; Glycine; Hippocampus; Kynurenic Acid; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Strychnine; Taurine

2005
Pharmacological characterization of glycine-activated currents in HEK 293 cells expressing N-methyl-D-aspartate NR1 and NR3 subunits.
    The Journal of pharmacology and experimental therapeutics, 2007, Volume: 322, Issue:2

    Topics: Alanine; Animals; Cell Line; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Glycine Plasma Membrane Transport Proteins; Humans; Kynurenic Acid; Membrane Potentials; Mice; Mutation; Patch-Clamp Techniques; Pyrrolidinones; Rats; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Sarcosine; Strychnine; Transfection

2007
Kinetic basis of partial agonism at NMDA receptors.
    Nature neuroscience, 2009, Volume: 12, Issue:9

    Topics: Action Potentials; Alanine; Amino Acids, Cyclic; Animals; Binding Sites; Cell Line; Cell Membrane; Cycloserine; Excitatory Amino Acid Agents; Glutamates; Glutamic Acid; Glycine; Humans; Kinetics; Kynurenic Acid; Models, Molecular; Rats; Receptors, N-Methyl-D-Aspartate

2009