kynurenic acid has been researched along with 7-chlorokynurenic acid in 236 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (3.81) | 18.7374 |
| 1990's | 171 (72.46) | 18.2507 |
| 2000's | 42 (17.80) | 29.6817 |
| 2010's | 13 (5.51) | 24.3611 |
| 2020's | 1 (0.42) | 2.80 |
| Authors | Studies |
|---|---|
| Baker, R; Carling, RW; Foster, AC; Grimwood, S; Kemp, JA; Leeson, PD; Marshall, GR; Moseley, AM | 1 |
| Baker, R; Carling, RW; Curtis, NR; Donald, AE; Foster, AC; Kemp, JA; Leeson, PD; Marshall, GR; Moore, KW; Williams, BJ | 1 |
| Baron, BM; Harrison, BL; McDonald, IA; Nyce, PL; Salituro, FG; Stewart, KT | 1 |
| Baron, BM; Cousino, DM; Harrison, BL; McDonald, IA | 1 |
| Iversen, LL; Leeson, PD | 1 |
| Bartlett, RD; Bridges, RJ; Carrigan, CN; Cybulski, KA; Esslinger, CS; Thompson, CM; Tongcharoensirikul, P | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Nicklas, WJ; Zeevalk, GD | 1 |
| Bostock, E; Sorrels, TL | 1 |
| Epstein, FH; Heyman, S; Rosen, S; Spokes, K | 1 |
| Inoue, K; Katayama, K; Morimoto, K; Namba, T; Otsuki, S; Yamada, N | 1 |
| Furukawa, H; Hasegawa, T; Maeda, Y; Nabeshima, T; Nakamura, T | 1 |
| Bussey, TJ; Phillips, AG; Wood, ER | 2 |
| Morimoto, K; Sato, M | 1 |
| Berger, TW; Thiels, E; Weisz, DJ | 1 |
| Lipton, SA; Zhang, D | 1 |
| Abarca, J; Bradberry, CW; Bustos, G; Forray, MI; Gysling, K; Roth, RH | 1 |
| Peeters, BW; Vanderheyden, PM | 1 |
| Dubner, R; Hylden, JL; Ren, K; Ruda, MA; Williams, GM | 1 |
| Aceves, J; Góngora-Alfaro, JL; Hernández, S; Martínez-Fong, D; Rosales, MG | 1 |
| Lodge, D; Millar, JD; Pralong, E | 1 |
| Fink, K; Göthert, M; Schultheiss, R | 1 |
| Colquhoun, D; Edwards, FA; Gibb, AJ | 1 |
| Gottesman, J; Miller, RF | 1 |
| Abe, K; Himi, T; Saito, H; Watanabe, Y | 1 |
| Chapman, V; Dickenson, AH | 3 |
| Barun, S; Dalkara, T; Erdemli, G; Onur, R | 1 |
| Koyama, T; Nakamura, F; Ohmori, T; Yamashita, I | 1 |
| Lazarewicz, JW; Puka, M; Salińska, E | 1 |
| Aamodt, SM; Kozlowski, MR; Nordeen, EJ; Nordeen, KW | 1 |
| Peterson, SL | 3 |
| DeFeo, PA; Hargrove, H; Patel, J; Salama, AI; Thompson, C; Zinkand, WC | 1 |
| Bradford, HF; Croucher, MJ | 2 |
| Wayman, CP; Wilson, JF | 1 |
| Abe, K; Mizutani, A; Saito, H | 1 |
| Armstrong, DM; Costa, E; Mereu, G; Vicini, S | 1 |
| Kemp, JA; Priestley, T | 1 |
| Canton, H; Colpaert, F; Lehmann, J | 1 |
| Collins, GG | 1 |
| Choi, DW; Goldberg, MP; Kaku, DA | 1 |
| Sircar, R; Zukin, SR | 1 |
| Blair, R; Woodward, JJ | 1 |
| Beart, PM; Conway, EL; Manallack, DT; Mercer, LD; O'Shea, RD | 1 |
| Frusciante, MJ; Javitt, DC; Nussenzveig, IZ; Sircar, R; Wong, ML; Zukin, SR | 1 |
| Kloog, Y; Lamdani-Itkin, H; Sokolovsky, M | 1 |
| Oles, RJ; Singh, L; Tricklebank, MD | 1 |
| Ascher, P; Henderson, G; Johnson, JW | 1 |
| Benveniste, M; Mayer, ML | 1 |
| Haesslein, JL; Hunt, PF; Jouanen, A; Massardier, D; Tremblet, AM | 1 |
| Aydar, E; Dickenson, AH | 1 |
| Bai, HY; Mosinger, JL; Olney, JW; Price, MT; Wozniak, DF; Xiao, H | 1 |
| Grillner, P; Grillner, S; Hill, R | 1 |
| Craig, CG; White, TD | 1 |
| Paschetto, KA; Pullan, LM; Verticelli, AM | 1 |
| Compton, RP; Cordi, AA; Hood, WF; Monahan, JB; Williams, RM | 1 |
| Insel, TR; Skolnick, P; Trullas, R; Winslow, JT | 1 |
| Bakshi, R; Faden, AI | 1 |
| Benveniste, M; Mayer, ML; Mienville, JM; Sernagor, E | 1 |
| Okamoto, K; Sakai, Y; Sekiguchi, M | 1 |
| Baimbridge, KG; Kessler, M; Lynch, G; Oliver, MW; Shacklock, JA | 1 |
| Kendall, DA; Robinson, JP | 1 |
| Bowen, DM; Cross, AJ; Francis, PT; Green, AR; Steele, JE | 1 |
| Dingledine, R; McNamara, D | 1 |
| Chiamulera, C; Costa, S; Reggiani, A | 1 |
| Keith, R; Patel, J; Salama, A; Thompson, C; Zinkand, WC | 1 |
| Britt, M; Klika, AB; Meiners, BA; Powel, RJ; Pullan, LM; Salama, AI; Stumpo, RJ | 1 |
| Aizenman, E; Reynolds, IJ; Rush, EA | 1 |
| Horne, AL; Kemp, JA; McKernan, RM; Priestley, T | 1 |
| Brugger, F; Fagg, GE; Nassenstein-Elton, D; Olpe, HR; Pozza, MF; Wicki, U | 1 |
| Colpaert, FC; Koek, W | 1 |
| Bashir, ZI; Collingridge, GL; Tam, B | 1 |
| Ferkany, JW; Kaplita, PV | 1 |
| Kessler, M; Larson, J; Lynch, G; Oliver, MW; Schottler, F | 1 |
| Benveniste, M; Mayer, ML; Vyklický, L | 1 |
| Larson, J; Lynch, G; Oliver, MW | 1 |
| Gale, K; Graham, J; Wardas, J | 1 |
| Clifford, DB; Izumi, Y; Zorumski, CF | 1 |
| Ceserani, R; Gaviraghi, G; Maraia, G; Reggiani, A | 1 |
| Chenard, B; Prochniak, M; Shalaby, I | 1 |
| Dingledine, R; Kleckner, NW | 1 |
| Frusciante, MJ; Javitt, DC; Sircar, R; Zukin, SR | 1 |
| Johnson, KM; Sacaan, AI | 1 |
| Harris, KM; Miller, RJ | 1 |
| Costa, E; Danysz, W; Fadda, E; Wroblewski, JT | 1 |
| Johnston, MV; McDonald, JW; Silverstein, FS; Uckele, JE | 1 |
| Foster, AC; Iversen, LL; Kemp, JA; Leeson, PD; Priestley, T; Tridgett, R; Woodruff, GN | 1 |
| Payne, RS; Rigor, BM; Schurr, A | 1 |
| Bubser, M; Kretschmer, BD; Schmidt, WJ | 1 |
| Baudry, M; Marvizón, JC | 2 |
| Domenici, MR; Longo, R; Sagratella, S; Scotti de Carolis, A | 1 |
| Han, D; Ogita, K; Yoneda, Y | 1 |
| Anantharam, V; Chu, B; Treistman, SN | 1 |
| MacDonald, JF; Wang, LY | 1 |
| Abe, K; Ikegaya, Y; Saito, H | 1 |
| Lehmann, JC; Procureur, D; Wood, PL | 1 |
| Mennini, T; Miari, A; Presti, ML; Rizzi, M; Samanin, R; Vezzani, A | 1 |
| Barth, A; Malouf, AT; Newell, DW | 1 |
| Flores, A; Soto, E; Vega, R | 1 |
| Carobrez, AP; Graeff, FG; Guimarães, FS; Matheus, MG; Nogueira, RL | 1 |
| Danysz, W; Kretschmer, BD; Schmidt, WJ; Winterscheid, B | 1 |
| Nolan, JP; Panizzon, KL; Wallis, RA | 1 |
| Becquet, D; Deprez, P; Fache, MP; Faudon, M; Giraud, P; Héry, F; Héry, M | 1 |
| Witkin, JM | 1 |
| Woodward, JJ | 1 |
| Eróstegui, C; Flores, A; Soto, E; Vega, R | 1 |
| Oblin, A; Schoemaker, H | 1 |
| Morrisett, RA | 1 |
| Bowser-Riley, F; Davies, SN; Shuker, MA | 1 |
| Frusciante, MJ; Javitt, DC; Zukin, SR | 1 |
| Löscher, W; Rundfeldt, C; Wlaź, P | 1 |
| Ohno, M; Watanabe, S; Yamamoto, T | 1 |
| Carter, C; Fage, D; Voltz, C | 1 |
| Berger, P; Farrel, K; Sharp, F; Skolnick, P | 1 |
| Greenamyre, JT; Porter, RH | 1 |
| Penney, JB; Sakurai, SY; Young, AB | 1 |
| Boje, KM; Skolnick, P; Wong, G | 1 |
| Bowery, NG; Gaviraghi, G; Marien, MR; Ratti, E; Tacconi, S | 1 |
| Lux, HD; Parsons, CG; Zong, X | 1 |
| Cattabeni, F; De Graan, PN; Di Luca, M; Gispen, WH; Ramakers, GM; Urban, IJ | 1 |
| Hirai, H; Okada, Y | 1 |
| Abe, K; Saito, H | 1 |
| Giberti, A; Mugnaini, M; Ratti, E; van Amsterdam, FT | 1 |
| Steele, RJ; Stewart, MG | 1 |
| Biella, G; Lacerenza, M; Marchettini, P; Sotgiu, ML | 1 |
| Bland, LR; Layer, RT; Skolnick, P | 1 |
| Morimoto, K; Namba, T; Otsuki, S; Yamada, N | 1 |
| Cler, JA; Cordi, AA; Dappen, MS; Emmett, MR; Gray, NM; Iyengar, S; Mick, SJ; Monahan, JB; Rao, TS; Wood, PL | 1 |
| Lu, L; Luo, J; McGonigle, P; Munir, M; Wang, YH; Wolfe, BB | 1 |
| Betz, H; Hirai, H; Kirsch, J; Kuhse, J; Laube, B | 1 |
| Domenici, MR; Marinelli, S; Sagratella, S | 1 |
| Pattarini, R; Pittaluga, A; Raiteri, M; Severi, P | 1 |
| Doyle, KM; Shaw, GG | 1 |
| Domenici, MR; Longo, R; Sagratella, S | 1 |
| Aniksztejn, L; Ben-Ari, Y | 1 |
| Kretschmer, BD; Schmidt, WJ | 1 |
| Chung, YT; Kim, SU; Lim, KT; Park, ST | 1 |
| Ault, B; Earley, WG; Hildebrand, LM; Kelly, MD; Luttinger, D; Mallamo, JP; Miller, MS; Ward, SJ | 1 |
| Gebhart, GF; Kolhekar, R | 1 |
| Gribkoff, VK; Molinoff, PB; Zhong, J | 1 |
| Badia, A; Clos, MV; Garcia Sanz, A; Trullas, R | 1 |
| Fujita, T; Ishizaki, K; Sudoh, M; Yoon, DM; Yoon, MH; Yoshida, N | 1 |
| Cull-Candy, SG; Feldmeyer, D; Momiyama, A | 1 |
| Couratier, P; Dussartre, C; Hugon, J; Lesort, M; Terro, F | 1 |
| Beninger, RJ; Boegman, RJ; Flesher, S; Jhamandas, KH; Pawley, AC | 1 |
| Johnson, SW; Wu, YN | 1 |
| Hill, RG; Kemp, JA; Laughton, P; Macaulay, AJ; Priestley, T | 1 |
| Salituro, FG; Schwarcz, R; Wu, HQ | 1 |
| Debler, K; Dieringer, N; Straka, H | 1 |
| Hokari, M; Schwarcz, R; Smith, QR; Wu, HQ | 1 |
| Bourguignon, JP; Czajkowski, V; Franchimont, P; Gérard, A; Lemaître, M; Moonen, G; Purnelle, G; Rigo, JM; Yamanaka, C | 1 |
| Gustafsson, B; Pananceau, M | 1 |
| Misawa, M; Suzuki, T; Tsuda, M | 2 |
| Koch, M; Kretschmer, BD | 2 |
| Arnelle, DR; Choi, YB; D'Emilia, DM; Kim, WK; Kumar, S; Lipton, SA; Rayudu, PV; Stamler, JS | 1 |
| Bettelini, L; Corsi, M; Fina, P; Trist, DG | 1 |
| Butterfield, BS; Grewal, RS; Stanley, BG | 1 |
| Kawabe, A; Maruoka, Y; Nakamura, M; Ohno, Y; Ohtani, K; Sakamoto, H; Tamamura, C; Tanaka, H; Yasuda, H | 1 |
| Churchill, D; Jarvis, CR; Lu, WY; MacDonald, JF; MacVicar, BA; Plant, JR; Xiong, ZG | 1 |
| Chiang, CY; Hu, JW; Sessle, BJ | 1 |
| Mancini, L; Mennini, T; Reggiani, A; Trist, D | 1 |
| Bannerman, DM; Butcher, SP; Good, MA; Morris, RG | 1 |
| Ashby, CR; Katsumori, H; Minabe, Y; Osawa, M | 1 |
| Turecek, R; Vlachová, V; Vyklický, L | 1 |
| Bonalumi, P; Carli, M; Samanin, R | 1 |
| Cugola, A; Donati, D; Micheli, F; Missio, A; Pecunioso, A; Reggiani, A; Tarzia, G | 1 |
| Dickenson, AH; Kerr, NC; Reeve, AJ | 1 |
| de Pádua Carobrez, A; De Souza, MM; Schenberg, LC | 1 |
| Capdevila, JL; Fossom, LH; Skolnick, P; Trullas, R; Viu, E; Zapata, A | 1 |
| Ivanovic, A; Kuhse, J; Laube, B; Reiländer, H | 1 |
| Boje, KM; Lakhman, SS | 1 |
| Liu, Y; von Euler, G | 1 |
| Foldes, JK; Hauser, KF; Turbek, CS | 1 |
| Bertrand, S; Cazalets, JR | 1 |
| Devau, G | 1 |
| Lee, SC; Schwarcz, R; Wu, HQ | 1 |
| Arenare, L; Battaglia, G; Bonina, F; Bruno, V; Copani, A; Ippolito, R; La Russa, M; Nicoletti, F | 1 |
| Guidetti, P; Schwarcz, R; Wu, HQ | 1 |
| Marinelli, S; Sagratella, S | 1 |
| Arenare, L; Battaglia, G; Boatto, G; Bonina, FP; Bruno, V; de Caprariis, P; Ippolito, R | 1 |
| Capdevila, J; Skolnick, P; Trullas, R; Viu, E; Zapata, A | 1 |
| Hicks, TP; Ito, K | 1 |
| Lee, SC; Schwarcz, R | 1 |
| Balducci, C; Carli, M; Samanin, R | 1 |
| Johnson, SW; Zheng, F | 1 |
| Alvarez, E; Bickford, PC; Browning, MD; Clayton, DA; Mesches, MH | 1 |
| Ito, A; Nagata, R; Nakamura, M; Ohtani, K; Tanaka, H; Yasuda, H; Yoneda, Y | 1 |
| Bakalkin, G; Esashi, A; Kisara, K; Nakagawasai, O; Niijima, F; Sakurada, C; Sakurada, T; Tadano, T; Tan-No, K; Terenius, L | 1 |
| Wu, E | 1 |
| Ceresoli-Borroni, G; Guidetti, P; Kiss, C; Schwarcz, R; Zielke, CL; Zielke, HR | 1 |
| Kamei, C; Nishiga, M | 1 |
| Bergeron, R; Krasteniakov, NV; Martina, M | 3 |
| Marszalec, W; Moriguchi, S; Narahashi, T; Yeh, JZ; Zhao, X | 1 |
| Ogonowski, AA; Smith, JB | 1 |
| Attwell, D; Billups, D | 1 |
| Barth, A; Barth, L; Newell, DW; Nguyen, LB | 1 |
| Bertram, EH; Goodman, JH; Rassoulpour, A; Scharfman, HE; Schwarcz, R; Wu, HQ | 1 |
| DiGregorio, DA; Nielsen, TA; Sargent, PB; Saviane, C; Silver, RA | 1 |
| Lamas, M; Lee-Rivera, I; López-Colomé, AM | 1 |
| Lee, SW; Stanley, BG | 1 |
| Bertram, EH; Schwarcz, R; Williamson, JM; Wu, HQ; Zhang, DX | 1 |
| Cao, H; Guo, JD; Ji, RR; Ren, WH; Sha, H; Wang, H; Wang, PF; Zhang, YQ; Zhao, ZQ | 1 |
| Bittencourt, AS; Carobrez, AP; Santos, P; Schenberg, LC | 1 |
| Solís, JM; Suárez, LM | 1 |
| Han, TZ; Li, YH | 1 |
| Benedikz, E; Duan, J; Mo-Boquist, LL; Nilsson, A; Sundström, E | 1 |
| Sun, H; Wang, HL; Wang, S | 1 |
| Esashi, A; Furuta, S; Nakagawasai, O; Niijima, F; Sato, T; Satoh, S; Tadano, T; Tan-No, K; Yasuhara, H | 1 |
| Smothers, CT; Woodward, JJ | 1 |
| Fernandez-Espejo, E; Moreno-Paublete, R; Portavella, M; Ramiro-Fuentes, S | 1 |
| Andersson, A; Engberg, G; Erhardt, S; Linderholm, KR; Olsson, E; Olsson, S; Snodgrass, R | 1 |
| Dubrovina, NI; Zinovyev, DR; Zinovyeva, DV | 1 |
| Chari, M; Cheung, GW; Kokorovic, A; Lai, TY; Lam, CK; Lam, TK; Su, BB; Wang, PY; Yang, CS | 1 |
| De Castro Bastos, L; Martins, MA; Melo, NE; Tonussi, CR | 1 |
| Harsing, LG; Kertesz, S; Levay, G; Matyus, P; Szabo, G; Udvari, S | 1 |
| Bihel, F; Bourguignon, JJ; Klein, C; Maitre, M; Mensah-Nyagan, AG; Patte-Mensah, C; Schmitt, M; Taleb, O | 1 |
| Alfonso, S; Aow, J; Fox, R; Kessels, HW; Malinow, R; Nabavi, S | 1 |
| Ding, ZB; Liu, JF; Liu, MM; Lu, L; Shi, HS; Wang, SJ; Zhang, RX; Zhu, WL | 1 |
| Brown, AM; Chen, S; Evans, RD; Hamner, MA; Ransom, BR; Yang, X; Ye, ZC | 1 |
| Alfonso, S; Aow, J; Fox, R; Malinow, R; Nabavi, S | 1 |
| Geng, D; Liu, BB; Liu, Q; Liu, XL; Luo, L; Yi, LT | 1 |
| Fukushima, T; Ichiba, H; Iwasa, S; Iwasaki, M; Izumi, M; Kashiwaguma, Y; Nagashima, C; Onozato, M; Uekusa, A | 1 |
| Chen, SM; Chen, XM; Geng, D; Li, CF; Liu, BB; Liu, Q; Liu, XL; Luo, L; Mu, RH; Yi, LT | 1 |
| Abraham, MA; Bauer, PV; Chan, O; Duca, FA; Filippi, BM; Lam, TK; LaPierre, MP; Wang, P; Yue, JT | 1 |
| Schwarcz, R; Snodgrass, HR; Yaksh, TL | 1 |
| Burada, AP; Kumar, J; Vinnakota, R | 1 |
1 review(s) available for kynurenic acid and 7-chlorokynurenic acid
| Article | Year |
|---|---|
The glycine site on the NMDA receptor: structure-activity relationships and therapeutic potential.
Topics: Animals; Anti-Anxiety Agents; Antipsychotic Agents; Binding Sites; Cognition; Glycine; Humans; Kynurenic Acid; Neuroprotective Agents; Pyrrolidinones; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 1994 |
235 other study(ies) available for kynurenic acid and 7-chlorokynurenic acid
| Article | Year |
|---|---|
2-Carboxytetrahydroquinolines. Conformational and stereochemical requirements for antagonism of the glycine site on the NMDA receptor.
Topics: Animals; Binding Sites; Cell Membrane; Cerebral Cortex; Glycine; Hippocampus; Kynurenic Acid; Magnetic Resonance Spectroscopy; Molecular Conformation; Molecular Structure; Quinolines; Rats; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; X-Ray Diffraction | 1992 |
Kynurenic acid derivatives. Structure-activity relationships for excitatory amino acid antagonism and identification of potent and selective antagonists at the glycine site on the N-methyl-D-aspartate receptor.
Topics: Animals; Binding, Competitive; Glycine; Indicators and Reagents; Kynurenic Acid; Molecular Structure; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 1991 |
3-(2-carboxyindol-3-yl)propionic acid derivatives: antagonists of the strychnine-insensitive glycine receptor associated with the N-methyl-D-aspartate receptor complex.
Topics: Animals; Binding Sites; Binding, Competitive; Cerebral Cortex; Glycine; Hippocampus; Indoles; Molecular Structure; N-Methylaspartate; Propionates; Rats; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Strychnine | 1990 |
4-[(Carboxymethyl)oxy]- and 4-[(carboxymethyl)amino]-5,7-dichloroquinoline-2-carboxylic acid: new antagonists of the strychnine-insensitive glycine binding site on the N-methyl-D-aspartate receptor complex.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Glycine; Kynurenic Acid; Molecular Structure; Quinolines; Rats; Receptors, N-Methyl-D-Aspartate; Strychnine | 1990 |
Synthesis and in vitro pharmacology of substituted quinoline-2,4-dicarboxylic acids as inhibitors of vesicular glutamate transport.
Topics: Animals; Carrier Proteins; Glutamic Acid; In Vitro Techniques; Kinetics; Male; Quinolines; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Synaptic Vesicles; Telencephalon | 2002 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Developmental differences in antagonism of NMDA toxicity by the polyamine site antagonist ifenprodil.
Topics: Amino Acids; Animals; Biogenic Polyamines; Chick Embryo; Dizocilpine Maleate; Kynurenic Acid; N-Methylaspartate; Pipecolic Acids; Piperidines; Receptors, Glutamate; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine; Retina | 1992 |
Induction of feeding by 7-chlorokynurenic acid, a strychnine-insensitive glycine binding site antagonist.
Topics: Analysis of Variance; Animals; Ataxia; Dose-Response Relationship, Drug; Feeding Behavior; Glycine; Injections, Intraventricular; Kynurenic Acid; Male; Muscle Contraction; Rats; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Serine; Strychnine | 1992 |
Mechanism of glycine protection in hypoxic injury: analogies with glycine receptor.
Topics: Animals; Dose-Response Relationship, Drug; Glycine; Hypoxia; In Vitro Techniques; Kidney; Kynurenic Acid; Male; Perfusion; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, Neurotransmitter; Serine | 1992 |
Effects of strychnine-insensitive glycine receptor antagonist (7-chlorokynurenic acid) on amygdala kindling in rats.
Topics: Amygdala; Analysis of Variance; Animals; Epilepsy; Kindling, Neurologic; Kynurenic Acid; Male; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, Neurotransmitter; Strychnine | 1992 |
Effect of salmon calcitonin on the lethality of quinolinic acid, an excitatory amino acid.
Topics: Amino Acids; Animals; Binding, Competitive; Calcitonin; Dose-Response Relationship, Drug; Drug Interactions; Kynurenic Acid; Lethal Dose 50; Male; Mice; Mice, Inbred Strains; Quinolinic Acid; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Salmon | 1992 |
A glycine antagonist reduces ischemia-induced CA1 cell loss in vivo.
Topics: Animals; Glycine; Hippocampus; Injections, Intraventricular; Ischemic Attack, Transient; Kynurenic Acid; Male; Pyramidal Tracts; Rats; Rats, Wistar; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures | 1992 |
NMDA receptor complex and kindling mechanisms.
Topics: Amygdala; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Electric Stimulation; Hippocampus; Kindling, Neurologic; Kynurenic Acid; Male; Neural Pathways; Pipecolic Acids; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses; Synaptic Transmission | 1992 |
In vivo modulation of N-methyl-D-aspartate receptor-dependent long-term potentiation by the glycine modulatory site.
Topics: 2-Amino-5-phosphonovalerate; Anesthesia; Animals; Electric Stimulation; Evoked Potentials; Hippocampus; Kynurenic Acid; Male; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Serine; Synapses | 1992 |
L-homocysteic acid selectively activates N-methyl-D-aspartate receptors of rat retinal ganglion cells.
Topics: 2-Amino-5-phosphonovalerate; Animals; Evoked Potentials; Glycine; Homocysteine; Kynurenic Acid; Rats; Receptors, N-Methyl-D-Aspartate; Retinal Ganglion Cells; Stimulation, Chemical | 1992 |
Regulation of excitatory amino acid release by N-methyl-D-aspartate receptors in rat striatum: in vivo microdialysis studies.
Topics: Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Corpus Striatum; Dialysis; Dizocilpine Maleate; Extracellular Space; Fluorometry; Glutamates; Glutamic Acid; Kynurenic Acid; Male; N-Methylaspartate; Perfusion; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Serine | 1992 |
In vitro and in vivo characterization of the NMDA receptor-linked strychnine-insensitive glycine site.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Dizocilpine Maleate; Glycine; Kynurenic Acid; Male; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures; Serine; Stereoisomerism; Strychnine | 1992 |
The intrathecal administration of excitatory amino acid receptor antagonists selectively attenuated carrageenan-induced behavioral hyperalgesia in rats.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analgesics; Analysis of Variance; Animals; Behavior, Animal; Carrageenan; Dizocilpine Maleate; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hyperalgesia; Inflammation; Injections, Spinal; Ketamine; Kynurenic Acid; Male; Piperazines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Valine | 1992 |
NMDA receptor mediates dopamine release in the striatum of unanesthetized rats as measured by brain microdialysis.
Topics: 2-Amino-5-phosphonovalerate; Animals; Atropine; Brain Chemistry; Corpus Striatum; Dialysis; Dopamine; Glycine; Kynurenic Acid; Magnesium; Male; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Tetrodotoxin | 1992 |
Specificity and potency of N-methyl-D-aspartate glycine site antagonists and of mephenesin on the rat spinal cord in vitro.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Glycine; Ibotenic Acid; Indoles; Kynurenic Acid; Mephenesin; N-Methylaspartate; Pyrrolidinones; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1992 |
Stimulation of noradrenaline release in human cerebral cortex mediated by N-methyl-D-aspartate (NMDA) and non-NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adult; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Cerebral Cortex; Dizocilpine Maleate; Dose-Response Relationship, Drug; Female; Glycine; Humans; Ibotenic Acid; Kainic Acid; Kynurenic Acid; Magnesium; Male; N-Methylaspartate; Norepinephrine; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Tetrodotoxin; Tritium | 1992 |
ATP receptor-mediated synaptic currents in the central nervous system.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Acetylcholine; Adenosine Triphosphate; Animals; Bicuculline; Brain; Chlorocebus aethiops; Evoked Potentials, Somatosensory; gamma-Aminobutyric Acid; Ganglionic Blockers; Glutamates; Glutamic Acid; Hexamethonium; Hexamethonium Compounds; In Vitro Techniques; Ion Channels; Kynurenic Acid; Mecamylamine; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Signal Transduction; Suramin; Tetrodotoxin | 1992 |
Pharmacological properties of N-methyl-D-aspartate receptors on ganglion cells of an amphibian retina.
Topics: 2-Amino-5-phosphonovalerate; Ambystoma; Amino Acids; Animals; Anticonvulsants; Dizocilpine Maleate; Electrodes; In Vitro Techniques; Ion Channels; Kynurenic Acid; Magnesium; Perfusion; Receptors, N-Methyl-D-Aspartate; Retinal Ganglion Cells; Tetrodotoxin; Zinc | 1992 |
Involvement of glycine site associated with the NMDA receptor in hippocampal long-term potentiation and acquisition of spatial memory in rats.
Topics: Animals; Binding Sites; Brain Mapping; Cerebral Ventricles; Evoked Potentials; Glycine; Hippocampus; In Vitro Techniques; Injections, Intraventricular; Kynurenic Acid; Male; Memory; Pyramidal Tracts; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Space Perception; Time Factors | 1992 |
The combination of NMDA antagonism and morphine produces profound antinociception in the rat dorsal horn.
Topics: Afferent Pathways; Animals; Electric Stimulation; Hot Temperature; Injections, Spinal; Kynurenic Acid; Morphine; N-Methylaspartate; Naloxone; Nerve Fibers; Neurons; Pain; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Touch | 1992 |
Glycine is required for NMDA receptor activation: electrophysiological evidence from intact rat hippocampus.
Topics: Animals; Dizocilpine Maleate; Electric Stimulation; Electrophysiology; Evoked Potentials; Glycine; Hippocampus; Iontophoresis; Ketamine; Kynurenic Acid; Magnesium; Male; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate; Time Factors | 1992 |
Amygdala kindling does not alter the N-methyl-D-aspartate receptor-channel complex which modulates dopamine release in the rat striatum and amygdala.
Topics: Amygdala; Animals; Corpus Striatum; Dizocilpine Maleate; Dopamine; In Vitro Techniques; Kindling, Neurologic; Kynurenic Acid; Male; Rats; Rats, Inbred WKY; Receptors, N-Methyl-D-Aspartate | 1992 |
Glycine enhances extracellular 45Ca2+ response to NMDA application investigated with microdialysis of rabbit hippocampus in vivo.
Topics: Amino Acids; Animals; Calcium; Calcium Radioisotopes; Dialysis; Drug Synergism; Extracellular Space; Glycine; Hippocampus; Kynurenic Acid; N-Methylaspartate; Rabbits; Receptors, N-Methyl-D-Aspartate; Serine | 1992 |
Distribution and developmental change in [3H]MK-801 binding within zebra finch song nuclei.
Topics: Aging; Animals; Auditory Pathways; Autoradiography; Binding, Competitive; Birds; Dizocilpine Maleate; Image Processing, Computer-Assisted; Kynurenic Acid; Male; Neostriatum; Piperazines; Prosencephalon; Receptors, N-Methyl-D-Aspartate; Vocalization, Animal | 1992 |
7-Chlorokynurenic acid antagonizes the anticonvulsant activity of D-cycloserine in maximal electroshock seizures.
Topics: Animals; Anticonvulsants; Cycloserine; Dose-Response Relationship, Drug; Electroshock; Injections, Intraventricular; Kynurenic Acid; Male; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1992 |
Quisqualate neurotoxicity in rat cortical cultures: pharmacology and mechanisms.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Kynurenic Acid; N-Methylaspartate; Neurons; Quinoxalines; Quisqualic Acid; Rats; Receptors, N-Methyl-D-Aspartate | 1992 |
The influence of strychnine-insensitive glycine receptor agonists and antagonists on generalized seizure thresholds.
Topics: Alanine; Amygdala; Animals; Glycine; Kindling, Neurologic; Kynurenic Acid; Male; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures; Serine; Strychnine | 1991 |
Characteristics of NMDA receptors that stimulate release of hypothalamic alpha-MSH.
Topics: alpha-MSH; Animals; Hypothalamus; In Vitro Techniques; Ketamine; Kinetics; Kynurenic Acid; Magnesium; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Serine | 1991 |
Anticonvulsant drug potentiation by glycine in maximal electroshock seizures is mimicked by D-serine and antagonized by 7-chlorokynurenic acid.
Topics: Animals; Anticonvulsants; Carbamazepine; Drug Synergism; Electroshock; Glycine; Kynurenic Acid; Male; Phenobarbital; Phenytoin; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures; Serine | 1991 |
Evidence for involvement of endogenous glycine in the induction of long-term potentiation in the dentate gyrus of anesthetized rats.
Topics: Anesthesia; Animals; Electric Stimulation; Glycine; Hippocampus; Kynurenic Acid; Male; Neuronal Plasticity; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Serine; Synapses; Synaptic Transmission; Time Factors | 1991 |
Glutamate receptor subtypes mediate excitatory synaptic currents of dopamine neurons in midbrain slices.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Dopamine; Evoked Potentials; Glutamates; In Vitro Techniques; Kynurenic Acid; Mecamylamine; Mesencephalon; Neurons; Picrotoxin; Quinoxalines; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Synapses | 1991 |
Effects of (+)-HA-966 and 7-chlorokynurenic acid on the kinetics of N-methyl-D-aspartate receptor agonist responses in rat cultured cortical neurons.
Topics: Animals; Binding, Competitive; Cells, Cultured; Cerebral Cortex; Glutamates; Glutamic Acid; Glycine; Kinetics; Kynurenic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Osmolar Concentration; Pyrrolidinones; Rats; Receptors, N-Methyl-D-Aspartate; Sodium | 1991 |
Glutamate and glycine co-activate while polyamines merely modulate the NMDA receptor complex.
Topics: 2-Amino-5-phosphonovalerate; Adrenergic alpha-Antagonists; Animals; Biguanides; Binding, Competitive; Biogenic Polyamines; Biotransformation; Brain; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; Kynurenic Acid; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine | 1991 |
Pharmacological evidence that NMDA receptors contribute to mono- and di-synaptic potentials in slices of mouse olfactory cortex.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cerebral Cortex; Evoked Potentials; In Vitro Techniques; Kynurenic Acid; Magnesium; Male; Mice; N-Methylaspartate; Olfactory Bulb; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Stereoisomerism; Synapses | 1991 |
Antagonism of non-NMDA receptors augments the neuroprotective effect of NMDA receptor blockade in cortical cultures subjected to prolonged deprivation of oxygen and glucose.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Culture Media; Dizocilpine Maleate; Fetus; Glucose; Kynurenic Acid; Mice; Neurons; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1991 |
Kinetic mechanisms of glycine requirement for N-methyl-D-aspartate channel activation.
Topics: Animals; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Kinetics; Kynurenic Acid; Male; Models, Biological; Prosencephalon; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Synaptosomes | 1991 |
Redox modulation of N-methyl-D-aspartate-stimulated neurotransmitter release from rat brain slices.
Topics: Animals; Biguanides; Brain; Disulfides; Dithionitrobenzoic Acid; Dithiothreitol; Dose-Response Relationship, Drug; In Vitro Techniques; Kynurenic Acid; Male; N-Methylaspartate; Neurotransmitter Agents; Osmolar Concentration; Oxidation-Reduction; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1991 |
Evidence for heterogenous glycine domains but conserved multiple states of the excitatory amino acid recognition site of the NMDA receptor: regional binding studies with [3H]glycine and [3H]L-glutamate.
Topics: Animals; Autoradiography; Binding, Competitive; Cerebellar Cortex; Cerebral Cortex; Cycloserine; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; Kynurenic Acid; Ligands; Male; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Serine | 1991 |
Polyamine effects upon N-methyl-D-aspartate receptor functioning: differential alteration by glutamate and glycine site antagonists.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding Sites; Cell Membrane; Cerebral Cortex; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Hippocampus; Kinetics; Kynurenic Acid; Male; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Spermidine | 1991 |
The glycine site of the N-methyl-D-aspartate receptor channel: differences between the binding of HA-966 and of 7-chlorokynurenic acid.
Topics: Animals; Binding Sites; Glycine; Ion Channels; Kynurenic Acid; Phencyclidine; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Strychnine | 1990 |
Modulation of seizure susceptibility in the mouse by the strychnine-insensitive glycine recognition site of the NMDA receptor/ion channel complex.
Topics: Acoustic Stimulation; Animals; Aspartic Acid; Diazepam; Injections, Intraventricular; Ion Channels; Kynurenic Acid; Male; Mice; Mice, Inbred DBA; N-Methylaspartate; Pentylenetetrazole; Piperazines; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures; Serine; Strychnine | 1990 |
Competitive antagonists and partial agonists at the glycine modulatory site of the mouse N-methyl-D-aspartate receptor.
Topics: Action Potentials; Animals; Brain; Cells, Cultured; Cerebral Cortex; Cycloserine; Diencephalon; Glycine; Ion Channels; Kynurenic Acid; Mice; N-Methylaspartate; Neurons; Pyrrolidinones; Receptors, N-Methyl-D-Aspartate | 1990 |
Kinetic analysis of antagonist action at N-methyl-D-aspartic acid receptors. Two binding sites each for glutamate and glycine.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding Sites; Biophysical Phenomena; Biophysics; Cells, Cultured; Glutamates; Glutamic Acid; Glycine; Hippocampus; Ion Channels; Kinetics; Kynurenic Acid; Models, Neurological; Piperazines; Receptors, N-Methyl-D-Aspartate | 1991 |
GABA release from mouse striatal neurons in primary culture as a test for the functional activity of N-methyl-D-aspartate (NMDA) antagonists.
Topics: Animals; Cells, Cultured; Corpus Striatum; Dizocilpine Maleate; Female; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Ion Channels; Kynurenic Acid; Ligands; Mice; N-Methylaspartate; Neurons; Pregnancy; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1991 |
Antagonism at the glycine site on the NMDA receptor reduces spinal nociception in the rat.
Topics: Anesthesia; Animals; Glycine; Kynurenic Acid; Nerve Fibers; Nerve Fibers, Myelinated; Neurons; Nociceptors; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1991 |
Blockade of both NMDA and non-NMDA receptors is required for optimal protection against ischemic neuronal degeneration in the in vivo adult mammalian retina.
Topics: Animals; Dose-Response Relationship, Drug; Female; Ischemia; Kynurenic Acid; Light; Nerve Degeneration; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Retinal Vein Occlusion; Retinal Vessels | 1991 |
7-Chlorokynurenic acid blocks NMDA receptor-induced fictive locomotion in lamprey--evidence for a physiological role of the glycine site.
Topics: Animals; Glycine; Kynurenic Acid; Lampreys; Locomotion; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1991 |
Endogenous glycine modulates N-methyl-D-aspartate-evoked release of adenosine and [3H]noradrenaline from rat cortical slices.
Topics: Adenosine; Animals; Cerebral Cortex; Glycine; In Vitro Techniques; Kynurenic Acid; Male; N-Methylaspartate; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Strychnine | 1991 |
Agonist-like character of the (R)-enantiomer of 1-hydroxy-3-amino-pyrrolid-2-one (HA-966).
Topics: Amino Acids; Amino Acids, Cyclic; Animals; Binding, Competitive; Dose-Response Relationship, Drug; Glycine; Kynurenic Acid; Male; Pyrrolidinones; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Spermine; Stereoisomerism; Synaptosomes | 1991 |
Identification of a novel structural class of positive modulators of the N-methyl-D-aspartate receptor, with actions mediated through the glycine recognition site.
Topics: Amino Acids; Animals; Brain; Dizocilpine Maleate; Glycine; In Vitro Techniques; Kinetics; Kynurenic Acid; Male; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Stereoisomerism; Structure-Activity Relationship; Synaptic Membranes | 1990 |
Rat pup isolation calls are reduced by functional antagonists of the NMDA receptor complex.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Amino Acids, Cyclic; Animals; Female; Glycine; Hippocampus; Kynurenic Acid; Male; N-Methylaspartate; Piperazines; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Social Isolation; Vocalization, Animal | 1990 |
Blockade of the glycine modulatory site of NMDA receptors modifies dynorphin-induced behavioral effects.
Topics: Animals; Dynorphins; Glycine; Indoles; Injections, Spinal; Kynurenic Acid; Male; Paralysis; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Concentration-jump experiments with NMDA antagonists in mouse cultured hippocampal neurons.
Topics: 2-Amino-5-phosphonovalerate; Alanine; Animals; Aspartic Acid; Cells, Cultured; Glycine; Hippocampus; Kynurenic Acid; Mice; N-Methylaspartate; Neurons; Osmolar Concentration; Piperazines | 1990 |
Glycine-insensitive NMDA-sensitive receptor expressed in Xenopus oocytes by guinea pig cerebellar mRNA.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Cerebellum; Electric Conductivity; Female; Glycine; Guinea Pigs; Kynurenic Acid; Magnesium; Male; Membrane Potentials; N-Methylaspartate; Oocytes; Phencyclidine; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; RNA, Messenger; Xenopus laevis | 1990 |
The glycine site modulates NMDA-mediated changes of intracellular free calcium in cultures of hippocampal neurons.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Calcium; Cells, Cultured; Embryo, Mammalian; Glycine; Hippocampus; Ketamine; Kinetics; Kynurenic Acid; Macromolecular Substances; N-Methylaspartate; Neurons; Rats; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Serine | 1990 |
The glycine antagonist 7-chlorokynurenic acid blocks the effects of N-methyl-D-aspartate on agonist-stimulated phosphoinositide hydrolysis in guinea-pig brain slices.
Topics: Animals; Brain; Glutamates; Glutamic Acid; Glycine; Guinea Pigs; Hydrolysis; In Vitro Techniques; Kynurenic Acid; N-Methylaspartate; Phosphatidylinositols; Receptors, N-Methyl-D-Aspartate | 1990 |
Spermidine enhancement of [3H]MK-801 binding to the NMDA receptor complex in human cortical membranes.
Topics: Adrenergic alpha-Antagonists; Aged; Aged, 80 and over; Cerebral Cortex; Dizocilpine Maleate; Female; Humans; In Vitro Techniques; Kynurenic Acid; Male; Membranes; Piperidines; Radioligand Assay; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spermidine | 1990 |
Dual effect of glycine on NMDA-induced neurotoxicity in rat cortical cultures.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cells, Cultured; Cerebral Cortex; Drug Synergism; gamma-Aminobutyric Acid; Glycine; Kynurenic Acid; L-Lactate Dehydrogenase; N-Methylaspartate; Nerve Degeneration; Neurons; Oocytes; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Taurine; Xenopus | 1990 |
Effect of NMDA- and strychnine-insensitive glycine site antagonists on NMDA-mediated convulsions and learning.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Injections, Intraventricular; Kynurenic Acid; Learning; Male; Mice; N-Methylaspartate; Piperazines; Receptors, Glycine; Receptors, Neurotransmitter; Seizures; Strychnine | 1990 |
Role of glycine in the N-methyl-D-aspartate-mediated neuronal cytotoxicity.
Topics: Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Glycine; Kynurenic Acid; N-Methylaspartate; Neurons; Piperazines; Pyrrolidinones; Serine | 1990 |
Stereoselective enhancement by (R)-HA-966 of the binding of [3H]CPP to the NMDA receptor complex.
Topics: Animals; In Vitro Techniques; Kynurenic Acid; Piperazines; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Spermine; Stereoisomerism; Strychnine; Synaptic Membranes | 1990 |
Reduction of NMDA receptors with dithiothreitol increases [3H]-MK-801 binding and NMDA-induced Ca2+ fluxes.
Topics: Animals; Calcium; Dithionitrobenzoic Acid; Dithiothreitol; Dizocilpine Maleate; Fluorescence; Fura-2; Glutamates; Glycine; In Vitro Techniques; Kynurenic Acid; N-Methylaspartate; Pipecolic Acids; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine | 1990 |
The effect of NMDA receptor glycine site antagonists on hypoxia-induced neurodegeneration of rat cortical cell cultures.
Topics: Animals; Binding Sites; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Fetus; Glycine; Hypoxia; Kinetics; Kynurenic Acid; L-Lactate Dehydrogenase; Nerve Degeneration; Neurons; Phosphopyruvate Hydratase; Pyrrolidinones; Rats; Receptors, N-Methyl-D-Aspartate | 1990 |
Modulation of the NMDA receptor by D-serine in the cortex and the spinal cord, in vitro.
Topics: Animals; Cerebral Cortex; Evoked Potentials; In Vitro Techniques; Kynurenic Acid; Male; Pyrrolidinones; Rats; Receptors, N-Methyl-D-Aspartate; Serine; Spinal Cord; Strychnine; Tetrodotoxin | 1990 |
Selective blockade of N-methyl-D-aspartate (NMDA)-induced convulsions by NMDA antagonists and putative glycine antagonists: relationship with phencyclidine-like behavioral effects.
Topics: Animals; Aspartic Acid; Dose-Response Relationship, Drug; Glycine; Kainic Acid; Kynurenic Acid; Male; Mice; Motor Activity; N-Methylaspartate; Oxadiazoles; Phencyclidine; Pyrrolidinones; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures | 1990 |
Activation of the glycine site in the NMDA receptor is necessary for the induction of LTP.
Topics: Action Potentials; Animals; Glycine; Hippocampus; Kynurenic Acid; Neuronal Plasticity; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synaptic Transmission | 1990 |
Evidence for direct interactions between the NMDA and glycine recognition sites in brain.
Topics: Amino Acids; Animals; Brain Chemistry; In Vitro Techniques; Kynurenic Acid; Male; Pipecolic Acids; Piperazines; Piperidines; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Serine | 1990 |
Glycine site associated with the NMDA receptor modulates long-term potentiation.
Topics: Adaptation, Physiological; Animals; Glycine; Hippocampus; Kynurenic Acid; Male; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Modulation of N-methyl-D-aspartic acid receptor desensitization by glycine in mouse cultured hippocampal neurones.
Topics: Animals; Cells, Cultured; Electrophysiology; Glycine; Hippocampus; Kynurenic Acid; Mice; Mice, Inbred Strains; Neurons; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Activation of the glycine site associated with the NMDA receptor is required for induction of LTP in neonatal hippocampus.
Topics: Animals; Animals, Newborn; Electric Stimulation; Electrophysiology; Glycine; Hippocampus; In Vitro Techniques; Kynurenic Acid; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Serine | 1990 |
7-Chlorokynurenic acid, a strychnine-insensitive glycine receptor antagonist, inhibits limbic seizure kindling.
Topics: Amygdala; Animals; Anticonvulsants; Electric Stimulation; Kindling, Neurologic; Kynurenic Acid; Limbic System; Male; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures; Strychnine | 1990 |
Evidence for a role of glycine in area tempestas for triggering convulsive seizures.
Topics: Animals; Anticonvulsants; Bicuculline; Carbachol; Cerebral Cortex; Glycine; Kainic Acid; Kynurenic Acid; Male; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures | 1990 |
Glycine antagonists block the induction of long-term potentiation in CA1 of rat hippocampal slices.
Topics: Action Potentials; Adaptation, Physiological; Amino Acids; Animals; Cycloleucine; Glycine; Hippocampus; In Vitro Techniques; Kynurenic Acid; Rats | 1990 |
Effect of 7-chloro kynurenic acid on glycine modulation of the N-methyl-D-aspartate response in guinea-pig myenteric plexus.
Topics: Animals; Aspartic Acid; Glycine; Guinea Pigs; In Vitro Techniques; Kynurenic Acid; Male; Myenteric Plexus; N-Methylaspartate; Serine | 1989 |
Glycine reverses 7-Cl kynurenate blockade of glutamate neurotoxicity in cell culture.
Topics: Animals; Cells, Cultured; Drug Interactions; Glutamates; Glycine; Hippocampus; Kynurenic Acid; L-Lactate Dehydrogenase; Nerve Degeneration; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Selectivity of quinoxalines and kynurenines as antagonists of the glycine site on N-methyl-D-aspartate receptors.
Topics: Animals; Aspartic Acid; Binding Sites; Binding, Competitive; Biological Assay; Glycine; Kainic Acid; Kynurenic Acid; N-Methylaspartate; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Structure-Activity Relationship; Xenopus laevis | 1989 |
Glycine reverses 7-chlorokynurenic acid-induced inhibition of [3H]MK-801 binding.
Topics: Animals; Dibenzocycloheptenes; Dizocilpine Maleate; Glycine; Kynurenic Acid; Male; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine | 1989 |
Spermine enhances binding to the glycine site associated with the N-methyl-D-aspartate receptor complex.
Topics: Animals; Dibenzocycloheptenes; Dizocilpine Maleate; Glycine; Kinetics; Kynurenic Acid; Magnesium; Rats; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spermine | 1989 |
CNQX (6-cyano-7-nitroquinoxaline-2,3-dione) antagonizes NMDA-evoked [3H]GABA release from cultured cortical neurons via an inhibitory action at the strychnine-insensitive glycine site.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Cells, Cultured; Cerebral Cortex; gamma-Aminobutyric Acid; Glycine; Kainic Acid; Kynurenic Acid; N-Methylaspartate; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Strychnine | 1989 |
Different modes of action of 3-amino-1-hydroxy-2-pyrrolidone (HA-966) and 7-chlorokynurenic acid in the modulation of N-methyl-D-aspartate-sensitive glutamate receptors.
Topics: Animals; Dibenzocycloheptenes; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; Kynurenic Acid; Piperazines; Protein Conformation; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Effect of glycine and glycine receptor antagonists on NMDA-induced brain injury.
Topics: Animals; Aspartic Acid; Brain; Dose-Response Relationship, Drug; Glycine; Kynurenic Acid; N-Methylaspartate; Organ Size; Rats; Rats, Inbred Strains | 1989 |
7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex.
Topics: Animals; Animals, Newborn; Aspartic Acid; Cells, Cultured; Cerebral Cortex; Electric Conductivity; Glycine; In Vitro Techniques; Kynurenic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1988 |
Protection by MK-801 against hypoxia-, excitotoxin-, and depolarization-induced neuronal damage in vitro.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anti-Anxiety Agents; Benzodiazepines; Diltiazem; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hippocampus; Hypoxia, Brain; In Vitro Techniques; Kynurenic Acid; Membrane Potentials; Neurons; Nifedipine; Pipecolic Acids; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 1995 |
Behavioral and neurochemical actions of the strychnine-insensitive glycine receptor antagonist, 7-chlorokynurenate, in rats.
Topics: Animals; Behavior, Animal; Corpus Striatum; Cycloserine; Dopamine; Drug Interactions; Excitatory Amino Acid Antagonists; Kynurenic Acid; Locomotion; Male; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Sensitivity and Specificity; Stereotyped Behavior; Strychnine | 1995 |
Allosteric interactions and modulator requirement for NMDA receptor function.
Topics: Allosteric Regulation; Animals; Brain Chemistry; Dizocilpine Maleate; Glutamic Acid; Glycine; In Vitro Techniques; Ion Channels; Kynurenic Acid; Male; Membranes; Protein Conformation; Rats; Rats, Sprague-Dawley; Receptors, Biogenic Amine; Receptors, N-Methyl-D-Aspartate; Spermine | 1994 |
Felbamate selectively blocks in vitro hippocampal kainate-induced irreversible electrical changes.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Electrophysiology; Felbamate; Hippocampus; Kainic Acid; Kynurenic Acid; Lamotrigine; Male; N-Methylaspartate; Pentobarbital; Phenylcarbamates; Propylene Glycols; Rats; Rats, Wistar; Triazines | 1995 |
Potentiation by calcium ions of [3H]MK-801 binding to an ion channel associated with the N-methyl-D-aspartate receptor complex in rat brain.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium; Dizocilpine Maleate; Ion Channels; Kynurenic Acid; Male; Phospholipases; Phospholipases A; Protein Binding; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synaptic Membranes | 1995 |
Ethanol inhibition of recombinant heteromeric NMDA channels in the presence and absence of modulators.
Topics: Animals; Electrophysiology; Ethanol; Female; Ion Channels; Kynurenic Acid; Magnesium; N-Methylaspartate; Oxidation-Reduction; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Xenopus laevis; Zinc | 1995 |
Modulation by magnesium of the affinity of NMDA receptors for glycine in murine hippocampal neurones.
Topics: Animals; Calcium; Cells, Cultured; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Glycine Agents; Hippocampus; In Vitro Techniques; Ion Channel Gating; Kynurenic Acid; Magnesium; Mice; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1995 |
Amygdala N-methyl-D-aspartate receptors participate in the induction of long-term potentiation in the dentate gyrus in vivo.
Topics: 2-Amino-5-phosphonovalerate; Amygdala; Animals; Evoked Potentials; Excitatory Amino Acid Antagonists; Hippocampus; Kynurenic Acid; Long-Term Potentiation; Male; Neuronal Plasticity; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1995 |
7-Chlorokynurenate prevents NMDA-induced and kainate-induced striatal lesions.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Diseases; Choline O-Acetyltransferase; Corpus Striatum; Dose-Response Relationship, Drug; Kainic Acid; Kynurenic Acid; Male; N-Methylaspartate; Quisqualic Acid; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Serine | 1993 |
Adaptive changes in the NMDA receptor complex in rat hippocampus after chronic treatment with CGP 39551.
Topics: 2-Amino-5-phosphonovalerate; Animals; Autoradiography; Dizocilpine Maleate; Glutamic Acid; Hippocampus; Kynurenic Acid; Male; Norepinephrine; Phencyclidine; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1994 |
Glycine site NMDA receptor antagonists provide protection against ischemia-induced neuronal damage in hippocampal slice cultures.
Topics: Animals; Brain Ischemia; Cell Death; Dizocilpine Maleate; Glycine; Glycine Agents; Hippocampus; Kynurenic Acid; Neurons; Organ Culture Techniques; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 1995 |
NMDA-mediated potentiation of the afferent synapse in the inner ear.
Topics: 2-Amino-5-phosphonovalerate; Ambystoma; Amplifiers, Electronic; Animals; Dizocilpine Maleate; Electrophysiology; Glycine; In Vitro Techniques; Kynurenic Acid; N-Methylaspartate; Neurons, Afferent; Physical Stimulation; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Synapses; Vestibule, Labyrinth | 1994 |
Anxiolytic effect of glycine antagonists microinjected into the dorsal periaqueductal grey.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Conditioning, Operant; Electric Stimulation; Glycine; Kynurenic Acid; Male; Microinjections; Periaqueductal Gray; Pyrrolidinones; Rats; Rats, Wistar; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 1994 |
Glycine site antagonists abolish dopamine D2 but not D1 receptor mediated catalepsy in rats.
Topics: Animals; Benzazepines; Catalepsy; Dose-Response Relationship, Drug; Drug Interactions; Haloperidol; Kynurenic Acid; Male; Motor Activity; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 1994 |
Glycine-induced CA1 excitotoxicity in the rat hippocampal slice.
Topics: Animals; Anticonvulsants; Chlorides; Drug Synergism; Evoked Potentials; Felbamate; Glycine; Hippocampus; Histidine; In Vitro Techniques; Kynurenic Acid; Magnesium Sulfate; Male; Phenylcarbamates; Propylene Glycols; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Zinc Compounds | 1994 |
N-methyl-D-aspartic acid/glycine interactions on the control of 5-hydroxytryptamine release in raphe primary cultures.
Topics: Animals; Cells, Cultured; Embryo, Mammalian; Female; Gestational Age; Glutamates; Glutamic Acid; Glycine; Kinetics; Kynurenic Acid; N-Methylaspartate; Pregnancy; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Rhombencephalon; Serotonin; Strychnine; Valine | 1993 |
Blockade of the locomotor stimulant effects of cocaine and methamphetamine by glutamate antagonists.
Topics: Amino Acids; Animals; Cocaine; Excitatory Amino Acid Antagonists; Glutamic Acid; Kynurenic Acid; Male; Methamphetamine; Mice; Motor Activity; Pyrrolidinones; Quinoxalines | 1993 |
A comparison of the effects of ethanol and the competitive glycine antagonist 7-chlorokynurenic acid on N-methyl-D-aspartic acid-induced neurotransmitter release from rat hippocampal slices.
Topics: Animals; Dose-Response Relationship, Drug; Ethanol; Glycine; Hippocampus; In Vitro Techniques; Kynurenic Acid; Male; N-Methylaspartate; Neurotransmitter Agents; Norepinephrine; Rats; Rats, Sprague-Dawley; Serine | 1994 |
Evidence for NMDA receptor in the afferent synaptic transmission of the vestibular system.
Topics: 2-Amino-5-phosphonovalerate; Ambystoma; Animals; Glycine; Hair Cells, Auditory; In Vitro Techniques; Kynurenic Acid; Magnesium; N-Methylaspartate; Nerve Fibers; Neurons, Afferent; Receptors, N-Methyl-D-Aspartate; Semicircular Canals; Synapses; Synaptic Transmission; Vestibule, Labyrinth | 1994 |
Complex allosteric modulation of the binding of the NMDA receptor antagonist [3H]CGP39653.
Topics: 2-Amino-5-phosphonovalerate; Allosteric Regulation; Animals; Biguanides; Binding Sites; Glycine; In Vitro Techniques; Kynurenic Acid; Male; Piperidines; Prosencephalon; Putrescine; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermine | 1994 |
Potentiation of N-methyl-D-aspartate receptor-dependent afterdischarges in rat dentate gyrus following in vitro ethanol withdrawal.
Topics: 2-Amino-5-phosphonovalerate; Animals; Electrophysiology; Ethanol; Hippocampus; Kynurenic Acid; Magnesium; Male; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome | 1994 |
Possible NMDA antagonist properties of drugs that affect high pressure neurological syndrome.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Alkaloids; Animals; Benzimidazoles; High Pressure Neurological Syndrome; Hippocampus; Indole Alkaloids; Kynurenic Acid; Mephenesin; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 1994 |
Activation-related and activation-independent effects of polyamines on phencyclidine receptor binding within the N-methyl-D-aspartate receptor complex.
Topics: Animals; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; Kinetics; Kynurenic Acid; Male; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Phencyclidine; Spermidine | 1994 |
Enhanced responses of rat dorsal horn neurons after UV irradiation of the hindpaw; roles of the NMDA receptor.
Topics: Action Potentials; Analysis of Variance; Animals; Electric Stimulation; Evoked Potentials; Female; Hindlimb; Injections, Spinal; Kynurenic Acid; Neurons; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sensory Thresholds; Spinal Cord; Time Factors; Ultraviolet Rays | 1994 |
Anticonvulsant activity of antagonists and partial agonists for the NMDA receptor-associated glycine site in the kindling model of epilepsy.
Topics: Animals; Anticonvulsants; Cycloserine; Differential Threshold; Epilepsy; Female; Glycine; Kindling, Neurologic; Kynurenic Acid; Pyrrolidinones; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1994 |
Intrahippocampal administration of a glycine site antagonist impairs working memory performance of rats.
Topics: Animals; Binding Sites; Glycine; Hippocampus; Kynurenic Acid; Male; Memory; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1994 |
Synergism between the NMDA receptor antagonistic effects of ifenprodil and the glycine antagonist, 7-chlorokynurenate, in vivo.
Topics: Animals; Chromatography, High Pressure Liquid; Drug Synergism; Glycine; Injections; Kynurenic Acid; Male; N-Methylaspartate; Neostriatum; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine | 1994 |
Drugs acting at the strychnine-insensitive glycine receptor do not induce HSP-70 protein in the cingulate cortex.
Topics: Amino Acids; Amino Acids, Cyclic; Animals; Dizocilpine Maleate; Gyrus Cinguli; Heat-Shock Proteins; Hippocampus; Immunohistochemistry; Kynurenic Acid; Male; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Strychnine | 1994 |
Inhibition of autoradiographic MK-801 binding by an endogenous factor.
Topics: Animals; Autoradiography; Brain Chemistry; Dizocilpine Maleate; Isoquinolines; Kynurenic Acid; Ligands; Rats; Receptors, N-Methyl-D-Aspartate | 1994 |
NMDA receptor activation by spermine requires glutamate but not glycine.
Topics: Animals; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Kynurenic Acid; Male; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermine | 1993 |
Regionally distinct N-methyl-D-aspartate receptors distinguished by quantitative autoradiography of [3H]MK-801 binding in rat brain.
Topics: Animals; Autoradiography; Brain; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Kinetics; Kynurenic Acid; Male; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tissue Distribution; Tritium | 1993 |
Desensitization of the NMDA receptor complex by glycinergic ligands in cerebellar granule cell cultures.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Amino Acids, Cyclic; Analysis of Variance; Animals; Base Sequence; Blotting, Northern; Cells, Cultured; Cerebellum; Dizocilpine Maleate; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Glycine; Kinetics; Kynurenic Acid; Molecular Sequence Data; Neurons; Neurotoxins; Oligodeoxyribonucleotides; Polymerase Chain Reaction; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Strychnine; Time Factors | 1993 |
Inhibition of [3H]-(+)-MK 801 binding to rat brain sections by CPP and 7-chlorokynurenic acid: an autoradiographic analysis.
Topics: Animals; Autoradiography; Brain; Cerebellum; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Image Processing, Computer-Assisted; In Vitro Techniques; Kynurenic Acid; Male; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1993 |
Whole cell and single channel analysis of the kinetics of glycine-sensitive N-methyl-D-aspartate receptor desensitization.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Cells, Cultured; Female; Glycine; Kinetics; Kynurenic Acid; N-Methylaspartate; Neurons; Pregnancy; Rats; Receptors, N-Methyl-D-Aspartate; Superior Colliculi; Synapses | 1993 |
The impaired long-term potentiation in the CA1 field of the hippocampus of cognitive deficient microencephalic rats is restored by D-serine.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Cognition Disorders; Electric Stimulation; Electrophysiology; Hippocampus; In Vitro Techniques; Kynurenic Acid; Picrotoxin; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serine; Synapses; Synaptic Transmission; Time Factors | 1993 |
Serine released from hippocampal slices during deprivation of oxygen and glucose enhances the effects of glutamate on neuronal function.
Topics: Adenosine Triphosphate; Amino Acids; Animals; Dizocilpine Maleate; Glucose; Glutamates; Glutamic Acid; Guinea Pigs; Hippocampus; Hypoxia; In Vitro Techniques; Kynurenic Acid; Neurons; Phosphocreatine; Receptors, N-Methyl-D-Aspartate; Serine; Synaptic Transmission | 1993 |
Pharmacological isolation and characterization of NMDA receptor-mediated synaptic potential in the dentate gyrus of rat hippocampal slices.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Evoked Potentials; Glycine; Hippocampus; In Vitro Techniques; Kynurenic Acid; Magnesium; Male; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synapses | 1993 |
Allosteric modulation of [3H]CGP 39653 binding by glycine in rat brain.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding, Competitive; Brain; Glycine; Kinetics; Kynurenic Acid; Male; Piperazines; Rats; Rats, Sprague-Dawley; Tritium | 1993 |
7-Chlorokynurenate, an antagonist of the glycine binding site on the NMDA receptor, inhibits memory formation in day-old chicks (Gallus domesticus).
Topics: Animals; Association Learning; Avoidance Learning; Brain Mapping; Chickens; Conditioning, Classical; Dominance, Cerebral; Injections; Kynurenic Acid; Long-Term Potentiation; Mental Recall; Neuronal Plasticity; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Retention, Psychology; Taste; Visual Cortex | 1993 |
Diazepam potentiation by glycine in pentylenetetrazol seizures is antagonized by 7-chlorokynurenic acid.
Topics: Animals; Diazepam; Drug Synergism; Glycine; Injections, Intraventricular; Kynurenic Acid; Male; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Seizures; Strychnine | 1994 |
Diverse modulation by systemic lidocaine of iontophoretic NMDA and quisqualic acid induced excitations on rat dorsal horn neurons.
Topics: Animals; Drug Synergism; Glycine; Injections, Intravenous; Iontophoresis; Kynurenic Acid; Lidocaine; Male; N-Methylaspartate; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Strychnine | 1993 |
MK-801, but not drugs acting at strychnine-insensitive glycine receptors, attenuate methamphetamine nigrostriatal toxicity.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amino Acids; Amino Acids, Cyclic; Animals; Corpus Striatum; Dizocilpine Maleate; Dopamine; Kynurenic Acid; Male; Methamphetamine; Mice; Mice, Inbred Strains; Receptors, Glycine; Strychnine; Substantia Nigra | 1993 |
Antiepileptogenic action of 7-chlorokynurenic acid on amygdala kindling of rats.
Topics: Amygdala; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electric Stimulation; Electroencephalography; Injections, Intraventricular; Kindling, Neurologic; Kynurenic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1993 |
Indole-2-carboxylates, novel antagonists of the N-methyl-D-aspartate (NMDA)-associated glycine recognition sites: in vivo characterization.
Topics: Animals; Brain; Cerebellum; Cyclic GMP; Harmaline; Indoleacetic Acids; Kynurenic Acid; Ligands; Male; Mice; N-Methylaspartate; Pyrrolidinones; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1993 |
A glycine antagonist 7-chlorokynurenic acid attenuates ischemia-induced learning deficits.
Topics: Analysis of Variance; Animals; Cerebral Ventricles; Discrimination, Psychological; Glycine; Hippocampus; Injections, Intraventricular; Ischemic Attack, Transient; Kynurenic Acid; Learning; Learning Disabilities; Male; Prosencephalon; Pyramidal Tracts; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1993 |
Pharmacological and immunological characterization of N-methyl-D-aspartate receptors in human NT2-N neurons.
Topics: Animals; Cells, Cultured; Dose-Response Relationship, Drug; Glutamic Acid; Humans; Immunoblotting; Kynurenic Acid; Neurons; Piperidines; Putrescine; Rats; Receptors, N-Methyl-D-Aspartate | 1996 |
The glycine binding site of the N-methyl-D-aspartate receptor subunit NR1: identification of novel determinants of co-agonist potentiation in the extracellular M3-M4 loop region.
Topics: Amino Acid Sequence; Bacterial Proteins; Binding Sites; Carrier Proteins; Epitopes; Excitatory Amino Acid Antagonists; Glycine; Kynurenic Acid; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligopeptides; Protein Conformation; Receptors, N-Methyl-D-Aspartate | 1996 |
Effects of felbamate, kynurenic acid derivatives and NMDA antagonists on in vitro kainate-induced epileptiform activity.
Topics: Animals; Anticonvulsants; Excitatory Amino Acid Antagonists; Felbamate; Hippocampus; In Vitro Techniques; Kainic Acid; Kynurenic Acid; Male; N-Methylaspartate; Neuroprotective Agents; Phenylcarbamates; Propylene Glycols; Rats; Rats, Wistar | 1996 |
Time-related roles of excitatory amino acid receptors during persistent noxiously evoked responses of rat dorsal horn neurones.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Evoked Potentials; Excitatory Amino Acid Antagonists; Formaldehyde; Injections, Spinal; Kynurenic Acid; Male; Neurons; Pain; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Time Factors | 1995 |
Human brain N-methyl-D-aspartate receptors regulating noradrenaline release are positively modulated by HIV-1 coat protein gp120.
Topics: Adult; Aged; Allosteric Site; Cerebral Cortex; Excitatory Amino Acid Antagonists; Female; Gene Products, env; Glycine; HIV Envelope Protein gp120; HIV-1; Humans; Kynurenic Acid; Male; Middle Aged; N-Methylaspartate; Norepinephrine; Peptide Fragments; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Synaptosomes | 1996 |
Investigation of the involvement of the N-methyl-D-aspartate receptor macrocomplex in the development of spermine-induced CNS excitation in vivo.
Topics: Animals; Brain; Cerebral Ventricles; Dizocilpine Maleate; Female; Kynurenic Acid; Mice; Neuroprotective Agents; Piperazines; Piperidines; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Seizures; Spermine; Tremor | 1996 |
7-chlorokynurenic acid prevents in vitro epileptiform and neurotoxic effects due to kainic acid.
Topics: Animals; Electrophysiology; Epilepsy; Excitatory Amino Acid Agonists; Hippocampus; In Vitro Techniques; Kainic Acid; Kynurenic Acid; Male; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1996 |
Expression of LTP by AMPA and/or NMDA receptors is determined by the extent of NMDA receptors activation during the tetanus.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Electric Stimulation; Excitatory Amino Acid Antagonists; Hippocampus; In Vitro Techniques; Kynurenic Acid; Long-Term Potentiation; Male; Membrane Potentials; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Receptors, Presynaptic | 1995 |
Behavioral effects mediated by the modulatory glycine site of the NMDA receptor in the anterodorsal striatum and nucleus accumbens.
Topics: Animals; Corpus Striatum; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glycine; Kynurenic Acid; Locomotion; Male; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1996 |
Methylmercury-induced neurotoxicity in cerebral neuron culture is blocked by antioxidants and NMDA receptor antagonists.
Topics: Animals; Antioxidants; Catalase; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutathione; Kynurenic Acid; Methylmercury Compounds; Mice; Neurons; Receptors, N-Methyl-D-Aspartate | 1996 |
WIN 63480, a hydrophilic TCP-site ligand, has reduced agonist-independent NMDA ion channel access compared to MK-801 and phencyclidine.
Topics: Animals; Binding Sites; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Kynurenic Acid; Membrane Potentials; Mice; Phencyclidine; Quinolizines; Receptors, N-Methyl-D-Aspartate; Transfection; Xenopus laevis | 1995 |
Modulation of spinal visceral nociceptive transmission by NMDA receptor activation in the rat.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Afferent Pathways; Animals; Colon; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Kynurenic Acid; Male; N-Methylaspartate; Neurons; Nociceptors; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Rectum; Serine; Skin; Spinal Cord; Synaptic Transmission | 1996 |
Use of subunit-specific antisense oligodeoxynucleotides to define developmental changes in the properties of N-methyl-D-aspartate receptors.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Animals, Newborn; Base Sequence; Cerebral Cortex; Excitatory Amino Acid Antagonists; Female; Gene Expression Regulation, Developmental; Glycine; Kynurenic Acid; Macromolecular Substances; Molecular Sequence Data; N-Methylaspartate; Oligonucleotides, Antisense; Oocytes; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Xenopus laevis | 1996 |
Effect of 1-aminocyclopropanecarboxylic acid on N-methyl-D-aspartate-stimulated [3H]-noradrenaline release in rat hippocampal synaptosomes.
Topics: Adrenergic alpha-Antagonists; Animals; Cyclopropanes; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; Kynurenic Acid; Male; N-Methylaspartate; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptosomes; Tritium | 1996 |
Intrathecally administered NMDA receptor antagonists reduce the MAC of isoflurane in rats.
Topics: Anesthetics, Inhalation; Animals; Excitatory Amino Acid Antagonists; Injections, Spinal; Isoflurane; Kynurenic Acid; Male; Piperazines; Pulmonary Alveoli; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Serine | 1996 |
Identification of a native low-conductance NMDA channel with reduced sensitivity to Mg2+ in rat central neurones.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cerebellar Nuclei; Electric Conductivity; Excitatory Amino Acid Antagonists; Hippocampus; In Vitro Techniques; Ion Channel Gating; Kynurenic Acid; Magnesium; Membrane Potentials; Neurons; Organ Specificity; Purkinje Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Spinal Cord; Transcription, Genetic | 1996 |
NMDA antagonist blockade of AT8 tau immunoreactive changes in neuronal cultures.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cell Survival; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; Fetus; Fluorescent Antibody Technique; Kynurenic Acid; Microscopy, Confocal; Neurons; Piperidines; Pregnancy; Rats; Receptors, N-Methyl-D-Aspartate; tau Proteins | 1996 |
Differential action of NMDA antagonists on cholinergic neurotoxicity produced by N-methyl-D-aspartate and quinolinic acid.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Brain; Choline O-Acetyltransferase; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Antagonism; Excitatory Amino Acid Antagonists; Kynurenic Acid; Male; N-Methylaspartate; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1996 |
Pharmacological characterization of inward current evoked by N-methyl-D-aspartate in dopamine neurons in the rat brain slice.
Topics: Animals; Dizocilpine Maleate; Excitatory Amino Acid Agonists; In Vitro Techniques; Kynurenic Acid; Magnesium; Male; Membrane Potentials; N-Methylaspartate; Phencyclidine; Piperidines; Rats; Rats, Sprague-Dawley; Sodium; Spermine; Substantia Nigra; Ventral Tegmental Area | 1996 |
Electrophysiological characterisation of the antagonist properties of two novel NMDA receptor glycine site antagonists, L-695,902 and L-701,324.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Electrophysiology; Excitatory Amino Acid Antagonists; Humans; Kinetics; Kynurenic Acid; Membrane Potentials; Mice; Neurons; Patch-Clamp Techniques; Quinolones; Rats; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 1996 |
Enzyme-catalyzed production of the neuroprotective NMDA receptor antagonist 7-chlorokynurenic acid in the rat brain in vivo.
Topics: Animals; Brain; Citrates; Excitatory Amino Acid Antagonists; Kynurenic Acid; Male; Neuroprotective Agents; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1997 |
Size-related properties of vestibular afferent fibers in the frog: differential synaptic activation of N-methyl-D-aspartate and non-N-methyl-D-aspartate receptors.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Afferent Pathways; Animals; Dose-Response Relationship, Drug; In Vitro Techniques; Isotonic Solutions; Kynurenic Acid; Nerve Fibers; Rana temporaria; Receptors, Amino Acid; Receptors, N-Methyl-D-Aspartate; Ringer's Solution; Synapses; Vestibular Nuclei | 1996 |
Facilitated brain uptake of 4-chlorokynurenine and conversion to 7-chlorokynurenic acid.
Topics: Amino Acids; Animals; Biotransformation; Brain; Excitatory Amino Acid Antagonists; Kynurenic Acid; Kynurenine; Male; Perfusion; Prodrugs; Rats; Rats, Sprague-Dawley | 1996 |
Duality of glutamatergic and GABAergic control of pulsatile GnRH secretion by rat hypothalamic explants: II. Reduced NR2C- and GABAA-receptor-mediated inhibition at initiation of sexual maturation.
Topics: Animals; Bicuculline; Excitatory Amino Acid Antagonists; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Gonadotropin-Releasing Hormone; Hypothalamus; Kynurenic Acid; Male; Muscimol; Oligonucleotides, Antisense; Periodicity; Rats; Receptors, GABA; Receptors, N-Methyl-D-Aspartate; Sexual Maturation | 1997 |
NMDA receptor dependence of the input specific NMDA receptor-independent LTP in the hippocampal CA1 region.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Calcium Channel Blockers; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Guinea Pigs; Hippocampus; In Vitro Techniques; Kynurenic Acid; Long-Term Potentiation; Male; Nifedipine; Receptors, N-Methyl-D-Aspartate | 1997 |
Role of the NMDA receptor complex in DMCM-induced seizure in mice.
Topics: Animals; Carbolines; Cerebral Ventricles; Convulsants; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Infusions, Intravenous; Injections, Intraventricular; Injections, Spinal; Kynurenic Acid; Male; Mice; Mice, Inbred Strains; Phencyclidine; Piperidines; Receptors, N-Methyl-D-Aspartate; Seizures; Spinal Cord | 1997 |
Role of the strychnine-insensitive glycine binding site in the nucleus accumbens and anterodorsal striatum in sensorimotor gating: a behavioral and microdialysis study.
Topics: Animals; Biogenic Monoamines; Chromatography, High Pressure Liquid; Dopamine; Electrochemistry; Glycine Agents; Kynurenic Acid; Male; Microdialysis; Microinjections; Neostriatum; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Reflex, Startle; Strychnine | 1997 |
Recovery of decreased seizure threshold for pentylenetetrazole during diazepam withdrawal by NMDA receptor antagonists.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Disease Models, Animal; Dizocilpine Maleate; Drug Interactions; Excitatory Amino Acid Antagonists; Infusions, Intravenous; Injections, Intraperitoneal; Injections, Subcutaneous; Kynurenic Acid; Male; Mice; Neuroprotective Agents; Pentylenetetrazole; Piperidines; Receptors, N-Methyl-D-Aspartate; Seizures; Substance Withdrawal Syndrome | 1997 |
Neurotoxicity associated with dual actions of homocysteine at the N-methyl-D-aspartate receptor.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adult; Animals; Cells, Cultured; Cerebral Cortex; Child; Dizocilpine Maleate; Embryo, Mammalian; Evoked Potentials; Glycine; Homocysteine; Humans; Kinetics; Kynurenic Acid; N-Methylaspartate; Neurons; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1997 |
Estimation of the relative potency of two glycine antagonists on NMDA-induced depolarizations in BRSC and ARCS.
Topics: Animals; Cerebral Cortex; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Kainic Acid; Kynurenic Acid; N-Methylaspartate; Potassium Chloride; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Synaptic Transmission | 1997 |
NMDA receptor coagonist glycine site: evidence for a role in lateral hypothalamic stimulation of feeding.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Eating; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Hypothalamic Area, Lateral; Kainic Acid; Kynurenic Acid; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1997 |
Selective depression of the spinal polysynaptic reflex by the NMDA receptor antagonists in an isolated spinal cord in vitro.
Topics: Animals; Depression, Chemical; Dizocilpine Maleate; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; In Vitro Techniques; Kynurenic Acid; Male; Piperazines; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reflex; Reflex, Monosynaptic; Serine; Spinal Cord; Spinal Nerve Roots; Strychnine; Valine | 1997 |
Neurotrophin modulation of NMDA receptors in cultured murine and isolated rat neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain-Derived Neurotrophic Factor; Calcium; Cells, Cultured; Corpus Striatum; Dynorphins; Embryo, Mammalian; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; Ion Channel Gating; Kynurenic Acid; Magnesium; Membrane Potentials; Mice; N-Methylaspartate; Nerve Growth Factors; Neurons; Neurotrophin 3; Protein Kinase Inhibitors; Pyramidal Cells; Rats; Rats, Wistar; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 1997 |
NMDA receptor involvement in neuroplastic changes induced by neonatal capsaicin treatment in trigeminal nociceptive neurons.
Topics: Animals; Animals, Newborn; Capsaicin; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Functional Laterality; Hindlimb; Injections, Spinal; Kynurenic Acid; Male; Medulla Oblongata; Neuronal Plasticity; Neurons; Nociceptors; Pain; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Trigeminal Nerve | 1997 |
GV 150526A, 7-Cl-kynurenic acid and HA 966 antagonize the glycine enhancement of N-methyl-D-aspartate-induced [3H]noradrenaline and [3H]dopamine release.
Topics: Animals; Dopamine; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; Indoles; Kynurenic Acid; Male; N-Methylaspartate; Neostriatum; Norepinephrine; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Synaptosomes | 1997 |
Intracerebroventricular infusion of the NMDA receptor-associated glycine site antagonist 7-chlorokynurenate impairs water maze performance but fails to block hippocampal long-term potentiation in vivo.
Topics: Animals; Brain; Brain Mapping; Dominance, Cerebral; Escape Reaction; Excitatory Amino Acid Antagonists; Hippocampus; Injections, Intraventricular; Kynurenic Acid; Long-Term Potentiation; Male; Maze Learning; Mental Recall; Neuronal Plasticity; Orientation; Rats; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Retention, Psychology | 1997 |
Acute effects of various GABA receptor agonists and glutamate antagonists on focal hippocampal seizures in freely moving rats elicited by low-frequency stimulation.
Topics: Animals; Anticonvulsants; Ataxia; Carbamazepine; Diazepam; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; GABA Agonists; Hippocampus; Kynurenic Acid; Male; Muscimol; Pipecolic Acids; Quinoxalines; Rats; Rats, Wistar; Seizures | 1998 |
Spontaneous openings of NMDA receptor channels in cultured rat hippocampal neurons.
Topics: Animals; Animals, Newborn; Cells, Cultured; Evoked Potentials; Hippocampus; Ion Channel Gating; Kynurenic Acid; Likelihood Functions; Magnesium; Membrane Potentials; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Rats; Receptors, N-Methyl-D-Aspartate | 1997 |
WAY 100635, a 5-HT1A receptor antagonist, prevents the impairment of spatial learning caused by intrahippocampal administration of scopolamine or 7-chloro-kynurenic acid.
Topics: Animals; Excitatory Amino Acid Antagonists; Hippocampus; Injections; Kynurenic Acid; Learning Disabilities; Male; Maze Learning; Muscarinic Antagonists; Piperazines; Pyridines; Rats; Rats, Sprague-Dawley; Scopolamine; Serotonin Antagonists | 1997 |
2,3-Dihydro-6,7-dichloro-pyrido[2,3-b]pyrazine-8-oxide as selective glycine antagonist with in vivo activity.
Topics: Animals; Avoidance Learning; Binding Sites; Cyclic N-Oxides; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glycine; Kynurenic Acid; Mice; Motor Activity; N-Methylaspartate; Neuroprotective Agents; Pyrazines; Rats; Receptors, N-Methyl-D-Aspartate; Seizures; Stereotyped Behavior; Strychnine | 1997 |
Spinal effects of bicuculline: modulation of an allodynia-like state by an A1-receptor agonist, morphine, and an NMDA-receptor antagonist.
Topics: Adenosine; Animals; Bicuculline; Dose-Response Relationship, Drug; GABA Antagonists; Kynurenic Acid; Male; Morphine; Naloxone; Nerve Fibers; Neurons; Pain; Physical Stimulation; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Touch | 1998 |
NMDA-coupled periaqueductal gray glycine receptors modulate anxioselective drug effects on plus-maze performance.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Binding, Competitive; Central Nervous System Stimulants; Diazepam; Injections, Intraperitoneal; Kynurenic Acid; Male; Pentylenetetrazole; Periaqueductal Gray; Rats; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 1998 |
Glycine site antagonists and partial agonists inhibit N-methyl-D-aspartate receptor-mediated [3H]arachidonic acid release in cerebellar granule cells.
Topics: Amino Acids; Amino Acids, Cyclic; Animals; Arachidonic Acid; Cerebellum; Glutamic Acid; Kynurenic Acid; N-Methylaspartate; Rats; Rats, Wistar; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 1998 |
The ventral pallidum mediates disruption of prepulse inhibition of the acoustic startle response induced by dopamine agonists, but not by NMDA antagonists.
Topics: Acoustic Stimulation; Animals; Apomorphine; Dizocilpine Maleate; Dopamine Agonists; Excitatory Amino Acid Antagonists; Globus Pallidus; Injections; Kynurenic Acid; Male; N-Methylaspartate; Neural Inhibition; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Reflex, Startle | 1998 |
Expression and initial characterization of a soluble glycine binding domain of the N-methyl-D-aspartate receptor NR1 subunit.
Topics: Animals; Baculoviridae; Binding Sites; Binding, Competitive; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Indoles; Kynurenic Acid; Protein Binding; Protein Conformation; Receptors, N-Methyl-D-Aspartate; Recombinant Fusion Proteins; Serine; Spodoptera | 1998 |
Chronic dosing with 1-aminocyclopropanecarboxylic acid, a glycine partial agonist, modulates NMDA inhibition of muscarinic-coupled PI hydrolysis in rat cortical slices.
Topics: 2-Amino-5-phosphonovalerate; Animals; Carbachol; Cerebral Cortex; Cycloleucine; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Hydrolysis; In Vitro Techniques; Inositol; Kynurenic Acid; Male; Muscarinic Agonists; N-Methylaspartate; Phosphatidylinositols; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1998 |
Na+, K+ and Ca2+ antagonize the glutamate- and glycine-induced decrease of [3H]MK-801 binding observed in the presence of Mg2+ at low pH.
Topics: Animals; Calcium; Cations; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamates; Glycine; Hydrogen-Ion Concentration; Kynurenic Acid; Magnesium; Male; Potassium; Protein Binding; Quinolones; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sodium | 1999 |
Dynorphin A (1-13) neurotoxicity in vitro: opioid and non-opioid mechanisms in mouse spinal cord neurons.
Topics: Analgesics, Opioid; Animals; Calcium; Cell Survival; Dizocilpine Maleate; Dynorphins; Embryo, Mammalian; Kynurenic Acid; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Neurotoxins; Peptide Fragments; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Valine | 1999 |
Regulation by glycine, Mg2+ and polyamines of the N-methyl-D-aspartate-induced locomotion in the neonatal rat spinal cord in vitro.
Topics: Animals; Biguanides; Excitatory Amino Acid Antagonists; Glycine; In Vitro Techniques; Kynurenic Acid; Magnesium; Motor Activity; Motor Neurons; N-Methylaspartate; Polyamines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermine; Spinal Cord; Synapses | 1999 |
Glycine induced calcium concentration changes in vestibular type I sensory cells.
Topics: Animals; Calcium; Chelating Agents; Chlorides; Egtazic Acid; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamates; Glycine; Guinea Pigs; Hair Cells, Vestibular; Kynurenic Acid; Models, Neurological; N-Methylaspartate; Strychnine | 2000 |
Systemic administration of 4-chlorokynurenine prevents quinolinate neurotoxicity in the rat hippocampus.
Topics: Animals; Brain Diseases; Dialysis Solutions; Hippocampus; Injections, Intraperitoneal; Kynurenic Acid; Kynurenine; Male; Microdialysis; Neuroprotective Agents; Prodrugs; Quinolinic Acid; Rats; Rats, Sprague-Dawley | 2000 |
Systemically administered D-glucose conjugates of 7-chlorokynurenic acid are centrally available and exert anticonvulsant activity in rodents.
Topics: Animals; Anticonvulsants; Astrocytes; Biotransformation; Blood-Brain Barrier; Cells, Cultured; Cerebral Cortex; Culture Media, Conditioned; Epilepsies, Partial; Epilepsy, Tonic-Clonic; Excitatory Amino Acid Antagonists; Galactose; Glucose; Injections, Intraperitoneal; Kynurenic Acid; Male; Mice; Microdialysis; Molecular Structure; N-Methylaspartate; Neurons; Neuroprotective Agents; Prodrugs; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship | 2000 |
In situ produced 7-chlorokynurenate provides protection against quinolinate- and malonate-induced neurotoxicity in the rat striatum.
Topics: 3-Hydroxyanthranilic Acid; Animals; Biotransformation; Corpus Striatum; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Infusions, Parenteral; Kynurenic Acid; Kynurenine; Male; Malonates; Neurons; Neuroprotective Agents; Prodrugs; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, Glycine | 2000 |
Effects of some GABA and NMDA antagonists on a model of presynaptic hippocampal paired pulse inhibition.
Topics: Animals; Calcium Channels; Excitatory Amino Acid Antagonists; GABA Antagonists; Hippocampus; Kynurenic Acid; Male; Penicillins; Rats; Rats, Wistar; Receptors, Presynaptic; Synaptic Transmission | 2000 |
Synthesis, pharmacokinetics and anticonvulsant activity of 7-chlorokynurenic acid prodrugs.
Topics: Animals; Blood-Brain Barrier; Cells, Cultured; Esters; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Kynurenic Acid; Mice; N-Methylaspartate; Neurons; Prodrugs; Seizures | 2000 |
Glycine(B) receptor antagonists and partial agonists prevent memory deficits in inhibitory avoidance learning.
Topics: Animals; Avoidance Learning; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Inhibition, Psychological; Kynurenic Acid; Male; Memory Disorders; Mice; Muscarinic Antagonists; Pyrrolidinones; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Retention, Psychology; Scopolamine | 2000 |
Effect of the glycine modulatory site of the N-methyl-D-aspartate receptor on synaptic responses in kitten visual cortex.
Topics: Animals; Binding Sites; Cats; Electric Stimulation; Excitatory Amino Acid Antagonists; Female; Glycine; Kynurenic Acid; Long-Term Potentiation; Male; Membrane Potentials; Neurons; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Serine; Synapses; Synaptic Transmission; Visual Cortex | 2001 |
Excitotoxic injury stimulates pro-drug-induced 7-chlorokynurenate formation in the rat striatum in vivo.
Topics: Animals; Corpus Striatum; Injections, Intraperitoneal; Kynurenic Acid; Kynurenine; Male; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Osmolar Concentration; Prodrugs; Quinolinic Acid; Rats; Rats, Sprague-Dawley | 2001 |
Stimulation of 5-HT(1A) receptors in the dorsal raphe ameliorates the impairment of spatial learning caused by intrahippocampal 7-chloro-kynurenic acid in naive and pretrained rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Conditioning, Operant; Excitatory Amino Acid Antagonists; Hippocampus; Kynurenic Acid; Male; Maze Learning; Piperazines; Pyridines; Raphe Nuclei; Rats; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists; Space Perception | 2001 |
Glycine receptor-mediated inhibition of dopamine and non-dopamine neurons of the rat ventral tegmental area in vitro.
Topics: Action Potentials; Animals; Dopamine; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; Glycine Agents; Kynurenic Acid; Male; Neural Inhibition; Neurons; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Strychnine; Synaptic Transmission; Tetrodotoxin; Ventral Tegmental Area | 2001 |
A hippocampal NR2B deficit can mimic age-related changes in long-term potentiation and spatial learning in the Fischer 344 rat.
Topics: Action Potentials; Aging; Animals; Behavior, Animal; Blotting, Western; Calcium Channel Blockers; Catheterization; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Gene Expression; Hippocampus; In Vitro Techniques; Kynurenic Acid; Long-Term Potentiation; Male; Maze Learning; Microinjections; Oligonucleotides, Antisense; Rats; Rats, Inbred F344; Receptors, N-Methyl-D-Aspartate; Spermine | 2002 |
In vitro and in vivo antagonistic activities of SM-31900 for the NMDA receptor glycine-binding site.
Topics: Aminoquinolines; Animals; Binding, Competitive; Brain; Cells, Cultured; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Fetus; Glutamic Acid; Indoles; Kynurenic Acid; Male; Neurons; Neuroprotective Agents; Neurotoxins; Radioligand Assay; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Seizures | 2002 |
Intrathecally administered big dynorphin, a prodynorphin-derived peptide, produces nociceptive behavior through an N-methyl-D-aspartate receptor mechanism.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Analgesics, Opioid; Animals; Behavior, Animal; Dizocilpine Maleate; Dynorphins; Endorphins; Enkephalins; Excitatory Amino Acid Antagonists; Injections, Spinal; Kynurenic Acid; Male; Mice; Morphine; Neurokinin A; Nociceptors; Peptide Fragments; Piperidines; Protein Precursors; Receptors, N-Methyl-D-Aspartate; Receptors, Tachykinin; Substance P | 2002 |
Evidence against the presence of NMDA receptors at a central glutamatergic synapse in leeches.
Topics: 2-Amino-5-phosphonovalerate; Animals; Association Learning; Central Nervous System; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Kynurenic Acid; Leeches; Motor Neurons; N-Methylaspartate; Neurons, Afferent; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Reflex; Synapses; Synaptic Transmission | 2002 |
Kynurenate production by cultured human astrocytes.
Topics: Aminooxyacetic Acid; Astrocytes; Brain; Cells, Cultured; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Fluorescent Antibody Technique; Glycine; Humans; Immunohistochemistry; Kynurenic Acid; Kynurenine; Leucine; Neuroprotective Agents; Nicotine; Oxaloacetic Acid; Phenylalanine; Pyruvic Acid; Receptors, Nicotinic; Transaminases | 2003 |
Ameliorative effects of histamine on 7-chlorokynurenic acid-induced spatial memory deficits in rats.
Topics: Animals; Excitatory Amino Acid Antagonists; Histamine; Kynurenic Acid; Male; Memory Disorders; Methylhistamines; Motor Activity; Polyamines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine | 2003 |
D-Serine differently modulates NMDA receptor function in rat CA1 hippocampal pyramidal cells and interneurons.
Topics: Animals; Axons; Electric Stimulation; Electrophysiology; Hippocampus; In Vitro Techniques; Interneurons; Kynurenic Acid; Membrane Potentials; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Serine; Tetrodotoxin | 2003 |
Potentiation of N-methyl-D-aspartate-induced currents by the nootropic drug nefiracetam in rat cortical neurons.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Electrophysiology; Female; Glycine; Kynurenic Acid; N-Methylaspartate; Neurons; Nootropic Agents; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate | 2003 |
Behavioral effects of NMDA receptor agonists and antagonists in combination with nitric oxide-related compounds.
Topics: 2-Amino-5-phosphonovalerate; Animals; Arginine; Conditioning, Operant; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Gallic Acid; Guanidines; Indazoles; Injections, Intraperitoneal; Kynurenic Acid; Molsidomine; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitroprusside; Phencyclidine; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2003 |
Active release of glycine or D-serine saturates the glycine site of NMDA receptors at the cerebellar mossy fibre to granule cell synapse.
Topics: Animals; Animals, Newborn; Binding, Competitive; Cerebellum; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; In Vitro Techniques; Kynurenic Acid; Models, Biological; Nerve Fibers; Neurons; Patch-Clamp Techniques; Rats; Receptors, N-Methyl-D-Aspartate; Serine | 2003 |
Subthreshold contribution of N-methyl-d-aspartate receptors to long-term potentiation induced by low-frequency pairing in rat hippocampal CA1 pyramidal cells.
Topics: Animals; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; Kynurenic Acid; Long-Term Potentiation; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Valine | 2004 |
Glycine-induced neurotoxicity in organotypic hippocampal slice cultures.
Topics: Alanine; Animals; Animals, Newborn; Brain Ischemia; Dose-Response Relationship, Drug; Drug Resistance; Glutamic Acid; Glycine; Hippocampus; Kynurenic Acid; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Strychnine; Taurine | 2005 |
Role of the glycine site of the N-methyl-D-aspartate receptor in synaptic plasticity induced by pairing.
Topics: Afferent Pathways; Animals; Electric Stimulation; Excitatory Postsynaptic Potentials; Glycine; Hippocampus; Kynurenic Acid; Long-Term Potentiation; Neuronal Plasticity; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Serine; Synapses | 2005 |
Kynurenate and 7-chlorokynurenate formation in chronically epileptic rats.
Topics: Animals; Astrocytes; Disease Models, Animal; Entorhinal Cortex; Epilepsy; Epilepsy, Temporal Lobe; Excitatory Amino Acid Antagonists; Gliosis; Hippocampus; In Vitro Techniques; Kynurenic Acid; Microdialysis; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 2005 |
Rapid vesicular release, quantal variability, and spillover contribute to the precision and reliability of transmission at a glomerular synapse.
Topics: Animals; Cerebellum; Evoked Potentials; Excitatory Amino Acid Antagonists; GABA Antagonists; In Vitro Techniques; Kynurenic Acid; Models, Neurological; Pyridazines; Quantum Theory; Rats; Rats, Sprague-Dawley; Strychnine; Synapses; Synaptic Transmission | 2005 |
Cell-specific expression of N-methyl-D-aspartate receptor subunits in Müller glia and neurons from the chick retina.
Topics: Animals; Blotting, Western; Cells, Cultured; Chick Embryo; Glycine; Isoenzymes; Kynurenic Acid; Neuroglia; Neurons; Radioligand Assay; Receptors, N-Methyl-D-Aspartate; Retina; Reverse Transcriptase Polymerase Chain Reaction; Serine; Spermine; Synaptic Membranes | 2005 |
NMDA receptors mediate feeding elicited by neuropeptide Y in the lateral and perifornical hypothalamus.
Topics: Analysis of Variance; Animals; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Feeding Behavior; Hypothalamus; Kynurenic Acid; Male; Microinjections; Neurons; Neuropeptide Y; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Satiety Response; Statistics, Nonparametric; Valine | 2005 |
In situ-produced 7-chlorokynurenate has different effects on evoked responses in rats with limbic epilepsy in comparison to naive controls.
Topics: Animals; Disease Models, Animal; Electric Stimulation; Electrodes, Implanted; Electroencephalography; Epilepsy; Evoked Potentials; Excitatory Amino Acid Antagonists; Kynurenic Acid; Limbic System; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 2005 |
Is endogenous D-serine in the rostral anterior cingulate cortex necessary for pain-related negative affect?
Topics: Animals; Anxiety; D-Amino-Acid Oxidase; Excitatory Amino Acid Antagonists; Fear; Glycine; Gyrus Cinguli; Kynurenic Acid; Male; Membrane Potentials; N-Methylaspartate; Organ Culture Techniques; Pain; Pain Measurement; Pain Threshold; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Serine; Stress, Psychological; Synaptic Transmission | 2006 |
Elevated T-maze evaluation of anxiety and memory effects of NMDA/glycine-B site ligands injected into the dorsal periaqueductal gray matter and the superior colliculus of rats.
Topics: Animals; Anxiety; Glycine; Kynurenic Acid; Ligands; Male; Maze Learning; Memory; Microinjections; Periaqueductal Gray; Rats; Rats, Wistar; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Serine; Stereoisomerism; Superior Colliculi | 2006 |
Taurine potentiates presynaptic NMDA receptors in hippocampal Schaffer collateral axons.
Topics: Animals; Axons; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Glycine; Hippocampus; Kynurenic Acid; Male; N-Methylaspartate; Organ Culture Techniques; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Serine; Synaptic Transmission; Taurine | 2006 |
Glycine binding sites of presynaptic NMDA receptors may tonically regulate glutamate release in the rat visual cortex.
Topics: Animals; Binding Sites; Binding, Competitive; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Glycine; Kynurenic Acid; Organ Culture Techniques; Presynaptic Terminals; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Visual Cortex | 2007 |
Characterisation of the human NMDA receptor subunit NR3A glycine binding site.
Topics: Animals; Binding, Competitive; Brain; Cell Line, Transformed; Cycloserine; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glycine; Humans; Kynurenic Acid; Models, Molecular; Mutation; Protein Binding; Rats; Receptors, N-Methyl-D-Aspartate; Transfection | 2007 |
D-serine relieves chronic lead exposure-impaired long-term potentiation in the CA1 region of the rat hippocampus in vitro.
Topics: Animals; Chronic Disease; Environmental Exposure; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; Kynurenic Acid; Lead; Lead Poisoning, Nervous System; Long-Term Potentiation; Mossy Fibers, Hippocampal; Neuroprotective Agents; Organ Culture Techniques; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Serine | 2007 |
Intrathecally administered D-cycloserine produces nociceptive behavior through the activation of N-methyl-D-aspartate receptor ion-channel complex acting on the glycine recognition site.
Topics: 2-Amino-5-phosphonovalerate; Agmatine; Animals; Cycloserine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Injections, Spinal; Ion Channels; Kynurenic Acid; Mice; Morphine; Neurokinin A; Nociceptors; Pain; Peptide Fragments; Piperidines; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Tachykinin; Substance P | 2007 |
Pharmacological characterization of glycine-activated currents in HEK 293 cells expressing N-methyl-D-aspartate NR1 and NR3 subunits.
Topics: Alanine; Animals; Cell Line; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Glycine Plasma Membrane Transport Proteins; Humans; Kynurenic Acid; Membrane Potentials; Mice; Mutation; Patch-Clamp Techniques; Pyrrolidinones; Rats; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Sarcosine; Strychnine; Transfection | 2007 |
Role for D-serine within the ventral tegmental area in the development of cocaine's sensitization.
Topics: Analysis of Variance; Animals; Behavior, Animal; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Drug Administration Schedule; Gene Expression Regulation, Enzymologic; Kynurenic Acid; Male; Microinjections; Motor Activity; Neuroprotective Agents; Rats; Rats, Wistar; Serine; Time Factors; Ventral Tegmental Area | 2008 |
Activation of rat ventral tegmental area dopamine neurons by endogenous kynurenic acid: a pharmacological analysis.
Topics: Aconitine; Action Potentials; Analysis of Variance; Animals; Biphenyl Compounds; Dopamine; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Kynurenic Acid; Male; Microdialysis; Neurons; Nicotinic Antagonists; Propionates; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Statistics, Nonparametric; Time Factors; Ventral Tegmental Area | 2007 |
N-methyl-D-aspartate receptors and amnesia in mice with depression-like state.
Topics: Amnesia; Analysis of Variance; Animals; Avoidance Learning; Behavior, Animal; Cycloserine; Depression; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Kynurenic Acid; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Receptors, Amino Acid | 2007 |
Activation of N-methyl-D-aspartate (NMDA) receptors in the dorsal vagal complex lowers glucose production.
Topics: 2-Amino-5-phosphonovalerate; Animals; Gene Knockdown Techniques; Glucose; Glycine; Humans; Kynurenic Acid; Liver; Male; N-Methylaspartate; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Vagotomy; Vagus Nerve | 2010 |
Dependency of nociception facilitation or inhibition after periaqueductal gray matter stimulation on the context.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Formaldehyde; Glycine; Kynurenic Acid; Male; Microinjections; Pain; Pain Measurement; Periaqueductal Gray; Pyrrolidinones; Rats; Rats, Wistar | 2010 |
Temporal alteration of spreading depression by the glycine transporter type-1 inhibitors NFPS and Org-24461 in chicken retina.
Topics: Animals; Chickens; CHO Cells; Cortical Spreading Depression; Cricetinae; Cricetulus; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine Plasma Membrane Transport Proteins; Humans; Kynurenic Acid; N-Methylaspartate; Retina; Sarcosine | 2013 |
The neuroprotector kynurenic acid increases neuronal cell survival through neprilysin induction.
Topics: Animals; Cell Survival; Cerebral Cortex; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Induction; Gene Expression; Humans; Kynurenic Acid; Mice; Neprilysin; Neurons; Neuroprotective Agents; Primary Cell Culture; Receptors, N-Methyl-D-Aspartate; Thiorphan | 2013 |
Metabotropic NMDA receptor function is required for NMDA receptor-dependent long-term depression.
Topics: Animals; Calcium Signaling; Chelating Agents; Dizocilpine Maleate; Egtazic Acid; Hippocampus; Kynurenic Acid; Long-Term Synaptic Depression; Neuronal Plasticity; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Tissue Culture Techniques | 2013 |
Glycine site N-methyl-D-aspartate receptor antagonist 7-CTKA produces rapid antidepressant-like effects in male rats.
Topics: Animals; Antidepressive Agents; Choice Behavior; Chromones; Dose-Response Relationship, Drug; Enzyme Activators; Feeding Behavior; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Helplessness, Learned; Hippocampus; Immobility Response, Tonic; Kynurenic Acid; Male; Microinjections; Morpholines; Nerve Tissue Proteins; Prefrontal Cortex; Rats; Receptors, N-Methyl-D-Aspartate; Stress, Psychological; TOR Serine-Threonine Kinases | 2013 |
Novel hypoglycemic injury mechanism: N-methyl-D-aspartate receptor-mediated white matter damage.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Brain; Calcium; Disease Models, Animal; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Glycogen; Hydrogen-Ion Concentration; Hypoglycemia; Kynurenic Acid; Lactic Acid; Leukoencephalopathies; Mice; Mice, Inbred C57BL; Optic Nerve Injuries; Quinoxalines; Receptors, N-Methyl-D-Aspartate | 2014 |
GluA1 trafficking and metabotropic NMDA: addressing results from other laboratories inconsistent with ours.
Topics: Animals; Genetic Vectors; Green Fluorescent Proteins; Hippocampus; Kynurenic Acid; Long-Term Synaptic Depression; Patch-Clamp Techniques; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Sindbis Virus; Synapses; Synaptic Transmission | 2014 |
7-Chlorokynurenic acid (7-CTKA) produces rapid antidepressant-like effects: through regulating hippocampal microRNA expressions involved in TrkB-ERK/Akt signaling pathways in mice exposed to chronic unpredictable mild stress.
Topics: Animals; Antidepressive Agents; Disease Models, Animal; Excitatory Amino Acid Antagonists; Kynurenic Acid; Male; MAP Kinase Signaling System; Mice; Mice, Inbred ICR; MicroRNAs; Stress, Psychological | 2015 |
A high-performance liquid chromatography assay with a triazole-bonded column for evaluation of d-amino acid oxidase activity.
Topics: Chromatography, High Pressure Liquid; D-Amino-Acid Oxidase; Hydrophobic and Hydrophilic Interactions; Kynurenic Acid; Kynurenine; Triazoles | 2016 |
Activation of hippocampal BDNF signaling is involved in the antidepressant-like effect of the NMDA receptor antagonist 7-chlorokynurenic acid.
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Depressive Disorder; Disease Models, Animal; Drug Evaluation, Preclinical; Hippocampus; Kidney; Kynurenic Acid; Liver; Male; MAP Kinase Signaling System; Mice, Inbred ICR; Random Allocation; Receptors, N-Methyl-D-Aspartate; Stress, Psychological; Uncertainty | 2016 |
Inhibition of glycine transporter-1 in the dorsal vagal complex improves metabolic homeostasis in diabetes and obesity.
Topics: Animals; Brain; Diabetes Mellitus, Experimental; Diet, High-Fat; Energy Metabolism; Gene Expression Regulation; Glycemic Index; Glycine Plasma Membrane Transport Proteins; Homeostasis; Kynurenic Acid; Male; Mice; Mice, Inbred C57BL; Obesity; Rats; Rats, Sprague-Dawley; Receptors, Lipoxin | 2016 |
Characterization of the Effects of L-4-Chlorokynurenine on Nociception in Rodents.
Topics: Amines; Analgesics; Animals; Brain; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Kynurenic Acid; Kynurenine; Male; Prodrugs; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 2017 |
Cryo-EM structures of the ionotropic glutamate receptor GluD1 reveal a non-swapped architecture.
Topics: Animals; Calcium; Cryoelectron Microscopy; HEK293 Cells; Humans; Kynurenic Acid; Models, Molecular; Protein Conformation; Protein Domains; Protein Multimerization; Rats; Receptors, Ionotropic Glutamate | 2020 |