kynurenic acid has been researched along with 3-hydroxykynurenine in 69 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (4.35) | 18.7374 |
| 1990's | 7 (10.14) | 18.2507 |
| 2000's | 13 (18.84) | 29.6817 |
| 2010's | 41 (59.42) | 24.3611 |
| 2020's | 5 (7.25) | 2.80 |
| Authors | Studies |
|---|---|
| Heyes, MP; Markey, SP; Saito, K | 1 |
| Bender, DA; Njagi, EN | 1 |
| Savvateeva, E | 1 |
| Fukui, S; Rapoport, SI; Schwarcz, R; Smith, QR; Takada, Y | 1 |
| Gramsbergen, JB; Schwarcz, R; Speciale, C; Vezzani, A | 1 |
| Izuta, S; Shibata, Y; Takeuchi, F; Tsubouchi, R | 1 |
| Abdel-Hamied, HA; Abdel-Tawab, GA; Aboul-Azm, T; Ebied, SA; el-Kholy, ZA; el-Sharaky, AS; el-Toukhy, MA | 1 |
| Allegri, G; Cardin Dè Stefani, EL; Costa, C; De Antoni, A; Vanzan, S | 1 |
| Egawa, B; Horiguchi, K; Shindo, I; Yamamoto, H | 1 |
| Watanabe, M | 1 |
| Ceresoli-Borroni, G; Goodman, JH; Guidetti, P; Scharfman, HE; Schwarcz, R; Speciale, C; Varasi, M; Wu, HQ | 1 |
| Pawlak, D; Takada, A; Takada, Y; Urano, T | 1 |
| Bragina, J; Heisenberg, M; Kamyshev, N; Kornhuber, J; Popov, A; Riederer, P; Savvateeva, E; Senitz, D | 1 |
| Baran, H; Herrera-Marschitz, M; Kepplinger, B; Lubec, G; Nohl, H; Stolze, K | 1 |
| Medoff, D; Rassoulpour, A; Roberts, RC; Schwarcz, R; Tamminga, CA; Wu, HQ | 1 |
| Buczko, W; Malyszko, J; Mysliwiec, M; Pawlak, D; Pawlak, K | 1 |
| Carpenedo, R; Meli, E; Moroni, F; Pellegrini-Giampietro, DE; Peruginelli, F | 1 |
| Hardeland, R; Zsizsik, BK | 1 |
| Bates, GP; Graham, RK; Guidetti, P; Hayden, MR; Leavitt, BR; MacDonald, ME; Schwarcz, R; Slow, EJ; Wheeler, VC; Woodman, B | 1 |
| da Costa Ferreira, G; de Souza Wyse, AT; Dutra-Filho, CS; Duval Wannmacher, CM; Latini, A; Schuck, PF; Tonin, A; Viegas, CM; Wajner, M | 1 |
| Amori, L; Ceresoli-Borroni, G; Guidetti, P; Pellicciari, R; Schwarcz, R | 1 |
| Amori, L; Guidetti, P; Marinozzi, M; Pellicciari, R; Schwarcz, R; Wu, HQ | 1 |
| Battsetseg, B; Battur, B; Boldbaatar, D; Fujisaki, K; Xuan, X | 1 |
| Bien, B; Gulaj, E; Pawlak, D; Pawlak, K | 1 |
| Kim, YK; Leonard, BE; Mueller, HH; Myint, AM; Scharpé, S; Schwarz, MJ; Steinbusch, HW; Verkerk, R; Zach, J | 1 |
| Breda, C; Campesan, S; Giorgini, F; Green, EW; Kyriacou, CP; Muchowski, PJ; Sathyasaikumar, KV; Schwarcz, R | 1 |
| Kloc, R; Kocki, J; Kocki, T; Owe-Larsson, B; Urbanska, EM; Wnuk, S | 1 |
| Agraharm, SG; Gundae, S; Munipally, PK; Turlapati, NR; Valavala, VK | 1 |
| Notarangelo, FM; Schwarcz, R; Wang, JZ; Wang, XD | 1 |
| Bruno, JP; Elmer, GI; Pocivavsek, A; Schwarcz, R; Wu, HQ | 1 |
| Plangar, I; Szalardy, L; Vecsei, L | 1 |
| Buerger, K; Guillemin, GJ; Hampel, H; Schwarz, MJ; Teipel, SJ | 1 |
| Eussen, SJ; Midttun, Ø; Nygård, O; Tell, GS; Theofylaktopoulou, D; Ueland, PM; Ulvik, A; Vollset, SE | 1 |
| Fukuwatari, T; Hiratsuka, C; Saito, K; Sano, M; Sasaki, S; Shibata, K | 1 |
| Chi, YY; Coats, B; da Silva, VR; Garrett, TJ; Gregory, JF; Lamers, Y; Midttun, Ø; Muller, KE; Percival, SS; Quinlivan, EP; Ralat, MA; Rios-Avila, L; Shankar, MN; Stacpoole, PW; Ueland, PM | 1 |
| Adler, M; Asp, L; Gardner, R; Hetta, J; Johansson, AS; Karlsson, H; Kocki, T; Lundkvist, GB; Owe-Larsson, B; Urbanska, EM | 1 |
| Horning, KJ; Notarangelo, FM; Schwarcz, R; Wang, XD | 1 |
| Fang, Q; Harris, TH; Horning, KJ; Hunter, CA; Notarangelo, FM; Schwarcz, R; Thomas, MA; Wilson, EH | 1 |
| Bellgowan, PS; Bodurka, J; Dantzer, R; Drevets, WC; Savitz, J; Smith, CM; Teague, TK; Victor, TA; Wurfel, BE | 1 |
| Bellgowan, PS; Bodurka, J; Dantzer, R; Drevets, WC; Ford, BN; Savitz, J; Teague, TK; Victor, TA; Wurfel, BE | 1 |
| Chi, YY; Coats, B; Gregory, JF; Midttun, Ø; Rios-Avila, L; Stacpoole, PW; Ueland, PM | 1 |
| Arts, B; Drukker, M; Guloksuz, S; Kenis, G; Myint, AM; Ponds, R; Rodriguez, L; Rutten, BP; Schwarz, MJ; van Os, J; Walter, S | 1 |
| Brody, LC; Brosnan, JT; Brosnan, ME; Deac, OM; Fan, R; Gibney, ER; Laird, E; Midttun, Ø; Mills, JL; Molloy, AM; Shane, B; Ueland, PM; Wang, Y | 1 |
| Bergink, V; Burgerhout, KM; Drexhage, HA; Hoogendijk, WJ; Kushner, SA; Myint, AM; Schütze, G; Schwarz, MJ; Veen, C | 1 |
| Dierkes, J; Drevon, CA; Gudbrandsen, OA; Karlsson, T; Midttun, Ø; Nygård, O; Pedersen, ER; Strand, E; Ueland, PM; Øyen, J | 1 |
| Bodurka, J; Dantzer, R; Drevets, WC; Ford, BN; Meier, TB; Morris, HM; Savitz, J; Teague, TK; Victor, TA; Wurfel, BE | 1 |
| de Bie, J; Grant, R; Guest, J; Guillemin, GJ | 1 |
| Azzinnari, D; Bergamini, G; Cathomas, F; Ceci, A; Fuertig, R; Hengerer, B; Luippold, A; Pryce, CR; Seifritz, E; Sigrist, H; Vavassori, S | 1 |
| Dabrowska, M; Jasiewicz, M; Kaminski, KA; Kazimierczyk, R; Knapp, M; Moniuszko, M; Musial, WJ; Pawlak, D; Rusak, M | 1 |
| Buras, A; Szulc, A; Waszkiewicz, N | 1 |
| Capi, M; Curto, M; Fazio, F; Giamberardino, MA; Lionetto, L; Martelletti, P; Negro, A; Nicoletti, F; Perugino, F; Simmaco, M | 1 |
| Bodurka, J; Dantzer, R; Drevets, WC; Savitz, J; Teague, TK; Young, KD | 1 |
| Engberg, G; Erhardt, S; Goiny, M; Liu, XC; Mathé, AA | 1 |
| Flis, M; Kandefer-Szerszeń, M; Karakuła-Juchnowicz, H; Kocki, T; Rosa, W; Szymona, K; Urbańska, EM; Zdzisińska, B | 1 |
| Bliss, SA; Dantzer, R; Drevets, WC; Ford, BN; McMillin, JR; Morris, HM; Savitz, JB; Suzuki, H; Teague, TK; Wurfel, BE | 1 |
| Bengesser, SA; Birner, A; Dalkner, N; Fellendorf, FT; Fuchs, D; Hamm, C; Herzog-Eberhard, S; Hörmanseder, C; Kainzbauer, N; Maget, A; Mangge, H; Mansur, RB; McIntyre, RS; Moll, N; Pilz, R; Platzer, M; Queissner, R; Rauch, P; Reininghaus, EZ; Schütze, G; Schwarz, MJ; Zelzer, S | 1 |
| Beggiato, S; Bonnin, A; Goeden, N; Notarangelo, FM; Pocivavsek, A; Schwarcz, R | 1 |
| Fülöp, F; Hertelendy, P; Toldi, J; Vécsei, L | 1 |
| Bryn, V; Ormstad, H; Saugstad, OD; Skjeldal, OH; Verkerk, R | 1 |
| Beggiato, S; Giorgini, F; Notarangelo, FM; Sathyasaikumar, KV; Schwarcz, R | 1 |
| Adams, S; Castellano-Gonzalez, G; Cole, NJ; Don, E; Guillemin, GJ; Jacobs, KR; Lim, CK; Lovejoy, DB | 1 |
| Baldessarini, RJ; Comparelli, A; Corigliano, V; Curto, M; Fazio, F; Ferracuti, S; Lionetto, L; Nicoletti, F; Simmaco, M | 1 |
| Beggiato, S; Notarangelo, FM; Schwarcz, R | 1 |
| Bernstein, HG; Guest, PC; Oxenkrug, G; Roeser, J; Steiner, J; Summergrad, P; van der Hart, M | 1 |
| Anderson, JF; Dahmani, M; Neelakanta, G; Sultana, H | 1 |
| Barajas-Martínez, K; Carrillo-Mora, P; Estrada-Cortés, B; Franyutti-Prado, K; Gamboa-Coria, G; Martínez-Cortéz, JA; Pérez-De la Cruz, V; Quinzaños-Fresnedo, J; Ramírez-Ortega, D; Ramos-Chávez, LA; Rangel-Caballero, F; Rodríguez-Barragán, M; Sánchez-Chapul, L; Sánchez-Vázquez, I; Toussaint-González, P | 1 |
| Avitabile, T; Choragiewicz, T; Fiedorowicz, M; Grieb, P; Kamińska, A; Kocki, T; Nowakowska, D; Rejdak, R; Toro, MD; Turski, WA; Wertejuk, K; Wełniak-Kaminska, M; Zweifel, S | 1 |
| Ostapiuk, A; Urbanska, EM | 1 |
| Hälsig, C; Hebbar, S; Knust, E; Traikov, S | 1 |
4 review(s) available for kynurenic acid and 3-hydroxykynurenine
| Article | Year |
|---|---|
[Microanalysis of tryptophan metabolites].
Topics: 3-Hydroxyanthranilic Acid; Animals; Fluorometry; Humans; Kynurenic Acid; Kynurenine; Mice; Microchemistry; Tryptophan; Ultraviolet Rays; Urinary Bladder Neoplasms | 1997 |
[Depression and inflammation in rheumatic diseases].
Topics: Cytokines; Depression; Humans; Hypothalamo-Hypophyseal System; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenic Acid; Kynurenine; Monoamine Oxidase; Pituitary-Adrenal System; Quinolinic Acid; Rheumatic Diseases; Serotonin | 2016 |
Ischemic Stroke and Kynurenines: Medicinal Chemistry Aspects.
Topics: Excitatory Amino Acid Antagonists; Humans; Kynurenic Acid; Kynurenine; Quinolinic Acids; Receptors, N-Methyl-D-Aspartate; Stroke; Tryptophan | 2018 |
Kynurenic acid in neurodegenerative disorders-unique neuroprotection or double-edged sword?
Topics: Alzheimer Disease; Animals; Brain; Excitatory Amino Acid Antagonists; Humans; Huntington Disease; Kynurenic Acid; Kynurenine; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Parkinson Disease; Quinolinic Acid; Signal Transduction | 2022 |
2 trial(s) available for kynurenic acid and 3-hydroxykynurenine
| Article | Year |
|---|---|
Supplementing healthy women with up to 5.0 g/d of L-tryptophan has no adverse effects.
Topics: Adolescent; Adult; Biomarkers; Body Mass Index; Cross-Over Studies; Dietary Supplements; Double-Blind Method; Female; Humans; Kynurenic Acid; Kynurenine; Niacinamide; ortho-Aminobenzoates; Placebos; Tryptophan; Young Adult | 2013 |
Metabolite profile analysis reveals association of vitamin B-6 with metabolites related to one-carbon metabolism and tryptophan catabolism but not with biomarkers of inflammation in oral contraceptive users and reveals the effects of oral contraceptives o
Topics: Adult; Biomarkers; Carbon; Contraceptives, Oral, Hormonal; Female; Humans; Inflammation; Kynurenic Acid; Kynurenine; Metabolome; Pyridoxal Phosphate; Tryptophan; United States; Vitamin B 6; Vitamin B 6 Deficiency | 2015 |
63 other study(ies) available for kynurenic acid and 3-hydroxykynurenine
| Article | Year |
|---|---|
Effects of immune activation on quinolinic acid and neuroactive kynurenines in the mouse.
Topics: Animals; Antibodies, Monoclonal; Brain; Immune System; Interferon-gamma; Kynurenic Acid; Kynurenine; Lipopolysaccharides; Lung; Male; Mice; Mice, Inbred C57BL; Models, Biological; Pokeweed Mitogens; Quinolinic Acid; Recombinant Proteins; Tryptophan | 1992 |
Tryptophan metabolism in mice infected with Schistosoma mansoni.
Topics: Animals; Cells, Cultured; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Liver; Male; Mice; Niacinamide; Schistosomiasis mansoni; Serotonin; Tryptophan; Xanthurenates | 1991 |
Kynurenines in the regulation of behavior in insects.
Topics: Action Potentials; Animal Communication; Animals; Bees; Behavior, Animal; Calmodulin; Drosophila melanogaster; Eye Color; Genes; Genotype; Insecta; Kynurenic Acid; Kynurenine; Learning; Phenothiazines; Stimulation, Chemical; Structure-Activity Relationship; Tryptophan; Xanthurenates | 1991 |
Blood-brain barrier transport of kynurenines: implications for brain synthesis and metabolism.
Topics: Animals; Biological Transport; Blood-Brain Barrier; Brain; Kynurenic Acid; Kynurenine; Male; ortho-Aminobenzoates; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains | 1991 |
Production of quinolinic acid and kynurenic acid by human glioma.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; 3-Hydroxyanthranilic Acid; Astrocytoma; Brain Neoplasms; Dioxygenases; Humans; Hydrolases; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Mixed Function Oxygenases; Neoplasm Proteins; Oxygenases; Quinolinic Acid; Quinolinic Acids | 1991 |
Kynurenine metabolism and xanthurenic acid formation in vitamin B6-deficient rat after tryptophan injection.
Topics: Animals; Hydrolases; Kidney; Kynurenic Acid; Kynurenine; Liver; Lyases; Male; Rats; Rats, Inbred Strains; Spectrometry, Fluorescence; Transaminases; Tryptophan; Vitamin B 6 Deficiency; Xanthurenates | 1989 |
The correlation between certain tryptophan metabolites and the N-nitrosamine content in the urine of bilharzial bladder cancer patients.
Topics: 3-Hydroxyanthranilic Acid; Adult; Aminohippuric Acids; Colorimetry; Humans; Indican; Kynurenic Acid; Kynurenine; Male; Middle Aged; Nitrosamines; ortho-Aminobenzoates; Schistosomiasis haematobia; Tryptophan; Urinary Bladder Neoplasms; Xanthurenates | 1986 |
Alterations of the tryptophan--nicotinic acid metabolism in vitiligo.
Topics: 3-Hydroxyanthranilic Acid; Adult; Female; Humans; Hydrolases; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Male; Melanins; Mixed Function Oxygenases; Models, Biological; Niacin; Tryptophan; Vitiligo; Xanthurenates | 1982 |
Kynurenic acid is decreased in cerebrospinal fluid of patients with infantile spasms.
Topics: Asphyxia Neonatorum; Brain; Chromatography, High Pressure Liquid; Electroencephalography; Female; Humans; Infant; Infant, Newborn; Kynurenic Acid; Kynurenine; Male; Spasms, Infantile; Synaptic Transmission; Tuberous Sclerosis | 1994 |
Kynurenergic manipulations influence excitatory synaptic function and excitotoxic vulnerability in the rat hippocampus in vivo.
Topics: 3-Hydroxyanthranilic Acid; Animals; Blood-Brain Barrier; Butyrates; Enzyme Inhibitors; Hippocampus; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Male; Mixed Function Oxygenases; Neuroprotective Agents; Neurotoxins; Pyramidal Cells; Quinolinic Acid; Rats; Rats, Sprague-Dawley | 2000 |
Serotonergic and kynurenic pathways in rats exposed to foot shock.
Topics: Animals; Brain; Brain Chemistry; Electroshock; Hydroxyindoleacetic Acid; Kidney; Kynurenic Acid; Kynurenine; Liver; Male; Rats; Rats, Wistar; Serotonin; Stress, Physiological; Tryptophan | 2000 |
Age-dependent memory loss, synaptic pathology and altered brain plasticity in the Drosophila mutant cardinal accumulating 3-hydroxykynurenine.
Topics: Age Factors; Animals; Courtship; Drosophila; Kynurenic Acid; Kynurenine; Learning; Male; Memory Disorders; Mutation; Neuroglia; Tryptophan | 2000 |
Increased kynurenic acid in the brain after neonatal asphyxia.
Topics: Animals; Animals, Newborn; Asphyxia; Brain; Disease Models, Animal; Kynurenic Acid; Kynurenine; Rats; Rats, Sprague-Dawley; Time Factors | 2001 |
Increased cortical kynurenate content in schizophrenia.
Topics: Adult; Aged; Aged, 80 and over; Animals; Antipsychotic Agents; Female; Frontal Lobe; Haloperidol; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Occipital Lobe; Rats; Rats, Sprague-Dawley; Schizophrenia | 2001 |
Accumulation of toxic products degradation of kynurenine in hemodialyzed patients.
Topics: Female; Humans; Kidney; Kynurenic Acid; Kynurenine; Male; Middle Aged; ortho-Aminobenzoates; Quinolinic Acid; Renal Dialysis; Tryptophan; Uremia; Xanthurenates | 2001 |
Kynurenine 3-mono-oxygenase inhibitors attenuate post-ischemic neuronal death in organotypic hippocampal slice cultures.
Topics: Alanine; Animals; Brain Ischemia; Cell Death; Cell Hypoxia; Culture Media, Conditioned; Enzyme Inhibitors; Glucose; Hippocampus; In Vitro Techniques; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Mixed Function Oxygenases; Neurons; Neuroprotective Agents; Pyramidal Cells; Quinolinic Acid; Rats; Sulfonamides; Thiazoles | 2002 |
Formation of kynurenic and xanthurenic acids from kynurenine and 3-hydroxykynurenine in the dinoflagellate Lingulodinium polyedrum: role of a novel, oxidative pathway.
Topics: Animals; Chromatography, High Pressure Liquid; Circadian Rhythm; Dinoflagellida; Kynurenic Acid; Kynurenine; Light; Oxidation-Reduction; Oxidative Stress; Transaminases; Tryptophan Transaminase; Xanthurenates | 2002 |
Elevated brain 3-hydroxykynurenine and quinolinate levels in Huntington disease mice.
Topics: Age Factors; Animals; Brain Chemistry; Chromatography, Gas; Chromatography, High Pressure Liquid; Disease Models, Animal; Humans; Huntington Disease; Kynurenic Acid; Kynurenine; Mice; Mice, Transgenic; Quinolinic Acid | 2006 |
Kynurenines impair energy metabolism in rat cerebral cortex.
Topics: 3-Hydroxyanthranilic Acid; Animals; Carbon Dioxide; Cerebral Cortex; Electron Transport; Energy Metabolism; Glucose; Kynurenic Acid; Kynurenine; ortho-Aminobenzoates; Rats; Rats, Wistar | 2007 |
Perinatal kynurenine 3-hydroxylase inhibition in rodents: pathophysiological implications.
Topics: Animals; Animals, Newborn; Brain Chemistry; Cyclopropanes; Deoxycholic Acid; Drug Administration Schedule; Embryo, Mammalian; Enzyme Inhibitors; Female; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Liver; Metabolic Networks and Pathways; Mice; Parturition; Pregnancy; Prenatal Exposure Delayed Effects; Quinolinic Acid; Rats; Rats, Sprague-Dawley | 2007 |
Specific inhibition of kynurenate synthesis enhances extracellular dopamine levels in the rodent striatum.
Topics: Adenosine; Animals; Animals, Newborn; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Drug Synergism; Extracellular Fluid; Functional Laterality; Kynurenic Acid; Kynurenine; Mice; Mice, Knockout; Microdialysis; Nerve Degeneration; Norbornanes; Quinolinic Acid; Transaminases; Tritium | 2009 |
Cloning and molecular characterization of tick kynurenine aminotransferase (HlKAT) from Haemaphysalis longicornis (Acari: Ixodidae).
Topics: Amino Acid Sequence; Animal Structures; Animals; Antiprotozoal Agents; Babesia; Base Sequence; Cloning, Molecular; DNA, Complementary; Enzyme Stability; Gene Expression Profiling; Hydrogen-Ion Concentration; Ixodidae; Kynurenic Acid; Kynurenine; Molecular Sequence Data; Phylogeny; Recombinant Proteins; Sequence Analysis, DNA; Sequence Homology; Substrate Specificity; Temperature; Transaminases; Xanthurenates | 2009 |
Kynurenine and its metabolites in Alzheimer's disease patients.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Chromatography, High Pressure Liquid; Female; Humans; Kynurenic Acid; Kynurenine; Male; ortho-Aminobenzoates; Quinolinic Acid; Tryptophan | 2010 |
Reversal of imbalance between kynurenic acid and 3-hydroxykynurenine by antipsychotics in medication-naïve and medication-free schizophrenic patients.
Topics: Adult; Algorithms; Antipsychotic Agents; Chromatography, High Pressure Liquid; Diagnostic and Statistical Manual of Mental Disorders; Female; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Patient Discharge; Schizophrenia; Schizophrenic Psychology; Spectrophotometry, Ultraviolet; Treatment Outcome; Tryptophan | 2011 |
The kynurenine pathway modulates neurodegeneration in a Drosophila model of Huntington's disease.
Topics: Animals; Animals, Genetically Modified; Disease Models, Animal; Drosophila melanogaster; Huntington Disease; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Nerve Degeneration; Neuroprotective Agents; Tryptophan; Tryptophan Oxygenase | 2011 |
New insight into the antidepressants action: modulation of kynurenine pathway by increasing the kynurenic acid/3-hydroxykynurenine ratio.
Topics: Animals; Animals, Newborn; Antidepressive Agents; Cells, Cultured; Dose-Response Relationship, Drug; Kynurenic Acid; Kynurenine; Neural Pathways; Rats; Rats, Wistar; Stereoisomerism | 2012 |
Evaluation of indoleamine 2,3-dioxygenase expression and kynurenine pathway metabolites levels in serum samples of diabetic retinopathy patients.
Topics: Biomarkers; Case-Control Studies; Chromatography, High Pressure Liquid; Diabetic Retinopathy; Female; Gene Expression; Humans; India; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Male; Middle Aged; Retina; Reverse Transcriptase Polymerase Chain Reaction; Severity of Illness Index; Tryptophan | 2011 |
Kynurenic acid and 3-hydroxykynurenine production from D-kynurenine in mice.
Topics: Animals; Brain Chemistry; Catalysis; Female; Kynurenic Acid; Kynurenine; Male; Mice; Mice, Inbred Strains; Stereoisomerism; Tryptophan | 2012 |
Pre- and postnatal exposure to kynurenine causes cognitive deficits in adulthood.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Chromatography, High Pressure Liquid; Cognition Disorders; Electrochemical Techniques; Female; Glutamic Acid; Kynurenic Acid; Kynurenine; Male; Maze Learning; Memory; Microdialysis; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Spatial Behavior | 2012 |
Manipulation with kynurenines: a possible tool for treating neurodegenerative diseases?
Topics: Animals; Drug Design; Humans; Kynurenic Acid; Kynurenine; Neurodegenerative Diseases; Quinolinic Acid | 2012 |
Increased 3-hydroxykynurenine serum concentrations differentiate Alzheimer's disease patients from controls.
Topics: Aged; Alzheimer Disease; Biomarkers; Blood-Brain Barrier; Brain Chemistry; Chromatography, High Pressure Liquid; Cognition Disorders; Female; Gas Chromatography-Mass Spectrometry; Humans; Kynurenic Acid; Kynurenine; Male; Neuropsychological Tests; Picolinic Acids; Quinolinic Acid; Spectrophotometry, Ultraviolet; Tryptophan | 2013 |
A community-based study on determinants of circulating markers of cellular immune activation and kynurenines: the Hordaland Health Study.
Topics: 3-Hydroxyanthranilic Acid; Aged; Aging; Biomarkers; Body Mass Index; Creatinine; Female; Humans; Inflammation; Kynurenic Acid; Kynurenine; Male; Middle Aged; Motor Activity; Neopterin; Norway; ortho-Aminobenzoates; Reference Values; Smoking; Tryptophan; Xanthurenates | 2013 |
Metabolite profile analysis reveals functional effects of 28-day vitamin B-6 restriction on one-carbon metabolism and tryptophan catabolic pathways in healthy men and women.
Topics: Adult; Biomarkers; Creatine; Cystathionine; Female; Humans; Inflammation; Kynurenic Acid; Kynurenine; Male; Multivariate Analysis; Postprandial Period; Pyridoxal Phosphate; Serine; Tryptophan; Vitamin B 6; Vitamin B 6 Deficiency; Young Adult | 2013 |
Activation of kynurenine pathway in ex vivo fibroblasts from patients with bipolar disorder or schizophrenia: cytokine challenge increases production of 3-hydroxykynurenine.
Topics: Adult; Bipolar Disorder; Cells, Cultured; Cytokines; Female; Fibroblasts; Gene Expression Regulation; Genotype; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Polymorphism, Single Nucleotide; Schizophrenia; Signal Transduction; Young Adult | 2013 |
A method for the determination of D-kynurenine in biological tissues.
Topics: Animals; Brain; Chromatography, High Pressure Liquid; D-Amino-Acid Oxidase; Female; Fluorometry; Kynurenic Acid; Kynurenine; Liver; Male; Mice; Plasma | 2013 |
Evaluation of kynurenine pathway metabolism in Toxoplasma gondii-infected mice: implications for schizophrenia.
Topics: Animals; Anti-Infective Agents; Brain; Disease Models, Animal; Drug Combinations; Female; Kynurenic Acid; Kynurenine; Mice; Mice, Inbred C57BL; Neuroglia; Pyrimethamine; Quinolinic Acid; RNA, Messenger; Signal Transduction; Sulfadiazine; Time Factors; Toxoplasmosis; Tryptophan | 2014 |
Putative neuroprotective and neurotoxic kynurenine pathway metabolites are associated with hippocampal and amygdalar volumes in subjects with major depressive disorder.
Topics: Adult; Amygdala; Anhedonia; Brain-Derived Neurotrophic Factor; C-Reactive Protein; Depressive Disorder, Major; Female; Gray Matter; Hippocampus; Humans; Kynurenic Acid; Kynurenine; Male; Organ Size; Psychiatric Status Rating Scales; Quinolinic Acid; Receptors, Interleukin-1; Signal Transduction; Tryptophan | 2015 |
Neuroprotective kynurenine metabolite indices are abnormally reduced and positively associated with hippocampal and amygdalar volume in bipolar disorder.
Topics: Adult; Amygdala; Bipolar Disorder; Female; Hippocampus; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Quinolinic Acid | 2015 |
The impact of electroconvulsive therapy on the tryptophan-kynurenine metabolic pathway.
Topics: Adult; Aged; Depressive Disorder; Electroconvulsive Therapy; Female; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Psychiatric Status Rating Scales; Tryptophan; Young Adult | 2015 |
Tryptophan catabolism and vitamin B-6 status are affected by gender and lifestyle factors in healthy young adults.
Topics: 3-Hydroxyanthranilic Acid; Adolescent; Adult; Arginine; Biomarkers; Dietary Supplements; Female; Healthy Volunteers; Humans; Kynurenic Acid; Kynurenine; Life Style; Male; Methionine; ortho-Aminobenzoates; Pyridoxal Phosphate; Sex Factors; Surveys and Questionnaires; Tryptophan; Vitamin B 6; Xanthurenates; Young Adult | 2015 |
Tryptophan pathway alterations in the postpartum period and in acute postpartum psychosis and depression.
Topics: Adult; Depression, Postpartum; Female; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Postpartum Period; Psychotic Disorders; Puerperal Disorders; Tandem Mass Spectrometry; Tryptophan; Young Adult | 2016 |
Associations between intake of fish and n-3 long-chain polyunsaturated fatty acids and plasma metabolites related to the kynurenine pathway in patients with coronary artery disease.
Topics: 3-Hydroxyanthranilic Acid; Aged; Animals; Biomarkers; Body Mass Index; Cholesterol; Coronary Artery Disease; Cross-Sectional Studies; Energy Intake; Fatty Acids, Omega-3; Female; Fishes; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Neopterin; Norway; Nutrition Assessment; ortho-Aminobenzoates; Seafood; Triglycerides; Tryptophan; Xanthurenates | 2017 |
Relationship between neurotoxic kynurenine metabolites and reductions in right medial prefrontal cortical thickness in major depressive disorder.
Topics: Adult; Brain; C-Reactive Protein; Case-Control Studies; Cerebral Cortex; Depressive Disorder, Major; Female; Gray Matter; Humans; Kynurenic Acid; Kynurenine; Magnetic Resonance Imaging; Male; Neurotoxicity Syndromes; Prefrontal Cortex; Quinolinic Acid; Tryptophan | 2016 |
Central kynurenine pathway shift with age in women.
Topics: Adult; Aged; Aged, 80 and over; Aging; Brain; Female; Humans; Inflammation; Kynurenic Acid; Kynurenine; Middle Aged; Neopterin; Neurotoxins; Quinolinic Acid; Tryptophan; Tryptophan Oxygenase; Young Adult | 2016 |
Mouse chronic social stress increases blood and brain kynurenine pathway activity and fear behaviour: Both effects are reversed by inhibition of indoleamine 2,3-dioxygenase.
Topics: Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Brain; Citalopram; Fear; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Male; Mice; Mice, Inbred C57BL; Motor Activity; Stress, Psychological; Tryptophan; Tumor Necrosis Factor-alpha | 2016 |
Activity of the kynurenine pathway and its interplay with immunity in patients with pulmonary arterial hypertension.
Topics: Adult; Aged; Area Under Curve; Case-Control Studies; Disease Progression; Echocardiography, Doppler; Exercise Test; Female; Flow Cytometry; Humans; Hypertension, Pulmonary; Kynurenic Acid; Kynurenine; Male; Middle Aged; ortho-Aminobenzoates; Prospective Studies; ROC Curve; T-Lymphocytes, Regulatory; Th17 Cells; Tryptophan | 2016 |
Altered serum levels of kynurenine metabolites in patients affected by cluster headache.
Topics: Adult; Cluster Headache; Female; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Male; Middle Aged; ortho-Aminobenzoates; Quinolinic Acid; Tryptophan; Xanthurenates | 2015 |
Kynurenine pathway metabolites are associated with hippocampal activity during autobiographical memory recall in patients with depression.
Topics: Adult; Depressive Disorder, Major; Female; Hippocampus; Humans; Kynurenic Acid; Kynurenine; Magnetic Resonance Imaging; Male; Memory, Episodic; Mental Recall; Middle Aged; Quinolinic Acid; Young Adult | 2016 |
Decreased levels of kynurenic acid in prefrontal cortex in a genetic animal model of depression.
Topics: Animals; Cerebellum; Chromatography, Liquid; Corpus Striatum; Depressive Disorder; Disease Models, Animal; Hippocampus; Kynurenic Acid; Kynurenine; Prefrontal Cortex; Rats; Tryptophan | 2017 |
Correlations of Kynurenic Acid, 3-Hydroxykynurenine, sIL-2R, IFN-α, and IL-4 with Clinical Symptoms During Acute Relapse of Schizophrenia.
Topics: Adult; Antipsychotic Agents; Clozapine; Female; Humans; Interferon-alpha; Interleukin-4; Kynurenic Acid; Kynurenine; Male; Psychiatric Status Rating Scales; Receptors, Interleukin-2; Recurrence; Retrospective Studies; Schizophrenia; Signal Transduction; Statistics, Nonparametric; Time Factors; Up-Regulation; Young Adult | 2017 |
Serum kynurenic acid is reduced in affective psychosis.
Topics: Adult; Affective Disorders, Psychotic; Bipolar Disorder; Corpus Striatum; Cytokines; Depression; Depressive Disorder, Major; Female; GABAergic Neurons; Humans; Inflammation; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Male; Middle Aged; Psychotic Disorders; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2017 |
Tryptophan breakdown and cognition in bipolar disorder.
Topics: Adult; Bipolar Disorder; Case-Control Studies; Cognition; Female; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Neuropsychological Tests; Sex Factors; Tryptophan | 2017 |
Prenatal Dynamics of Kynurenine Pathway Metabolism in Mice: Focus on Kynurenic Acid.
Topics: Animals; Brain; Female; Kynurenic Acid; Kynurenine; Mice; Placenta; Pregnancy; Tryptophan | 2017 |
Kynurenine Pathway in Autism Spectrum Disorders in Children.
Topics: Autism Spectrum Disorder; Biomarkers; Child; Chromatography, High Pressure Liquid; Comorbidity; Female; Humans; Kynurenic Acid; Kynurenine; Male; Quinolinic Acid; Tryptophan | 2017 |
Maternal genotype determines kynurenic acid levels in the fetal brain: Implications for the pathophysiology of schizophrenia.
Topics: Animals; Brain; Cognitive Dysfunction; Female; Genotype; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Mice; Mice, Inbred C57BL; Mice, Knockout; Placenta; Pregnancy; Quinolinic Acid; Schizophrenia | 2018 |
Kynurenine 3-Monooxygenase Activity in Human Primary Neurons and Effect on Cellular Bioenergetics Identifies New Neurotoxic Mechanisms.
Topics: Adenosine Triphosphate; Brain; Cell Survival; HEK293 Cells; Humans; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Diseases; NAD; Neurons; Oxidative Stress; Primary Cell Culture; Quinolinic Acid; Reactive Oxygen Species | 2019 |
Serum xanthurenic acid levels: Reduced in subjects at ultra high risk for psychosis.
Topics: Adolescent; Adult; Disease Progression; Female; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Male; ortho-Aminobenzoates; Prodromal Symptoms; Psychotic Disorders; Quinolinic Acid; Risk; Schizophrenia; Tryptophan; Xanthurenates; Young Adult | 2019 |
Assessment of Prenatal Kynurenine Metabolism Using Tissue Slices: Focus on the Neosynthesis of Kynurenic Acid in Mice.
Topics: Animals; Brain; Female; Fetus; Kynurenic Acid; Kynurenine; Liver; Mice; Mice, Knockout; Organ Culture Techniques; Placenta; Pregnancy; Transaminases | 2019 |
Plasma xanthurenic acid in a context of insulin resistance and obesity in schizophrenia.
Topics: Case-Control Studies; Humans; Insulin Resistance; Kynurenic Acid; Kynurenine; Obesity; Schizophrenia; Xanthurenates | 2019 |
Rickettsial pathogen uses arthropod tryptophan pathway metabolites to evade reactive oxygen species in tick cells.
Topics: Anaplasma phagocytophilum; Animals; Hemin; Host-Pathogen Interactions; Hydrolases; Ixodes; Kynurenic Acid; Kynurenine; NADP; Reactive Oxygen Species; RNA Interference; Transaminases; Tryptophan; Tryptophan Oxygenase; Up-Regulation; Xanthurenates | 2020 |
Serum Kynurenines Correlate With Depressive Symptoms and Disability in Poststroke Patients: A Cross-sectional Study.
Topics: Adult; Aged; Case-Control Studies; Cross-Sectional Studies; Depression; Female; Functional Status; Humans; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Male; Middle Aged; Psychiatric Status Rating Scales; Severity of Illness Index; Stroke | 2020 |
Tryptophan Pathway Abnormalities in a Murine Model of Hereditary Glaucoma.
Topics: Animals; Biomarkers; Disease Models, Animal; Disease Susceptibility; Genetic Diseases, Inborn; Glaucoma; Kynurenic Acid; Kynurenine; Magnetic Resonance Imaging; Metabolic Networks and Pathways; Mice; Retina; Species Specificity; Tryptophan | 2021 |
Modulating the Kynurenine pathway or sequestering toxic 3-hydroxykynurenine protects the retina from light-induced damage in Drosophila.
Topics: Animals; Drosophila; Drosophila melanogaster; Kynurenic Acid; Kynurenine; Retina | 2023 |