Page last updated: 2024-09-04

kw 2189 and caffeine

kw 2189 has been researched along with caffeine in 1 studies

*Caffeine: A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine's most notable pharmacological effect is as a central nervous system stimulant, increasing alertness and producing agitation. It also relaxes SMOOTH MUSCLE, stimulates CARDIAC MUSCLE, stimulates DIURESIS, and appears to be useful in the treatment of some types of headache. Several cellular actions of caffeine have been observed, but it is not entirely clear how each contributes to its pharmacological profile. Among the most important are inhibition of cyclic nucleotide PHOSPHODIESTERASES, antagonism of ADENOSINE RECEPTORS, and modulation of intracellular calcium handling. [MeSH]

*Caffeine: A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine's most notable pharmacological effect is as a central nervous system stimulant, increasing alertness and producing agitation. It also relaxes SMOOTH MUSCLE, stimulates CARDIAC MUSCLE, stimulates DIURESIS, and appears to be useful in the treatment of some types of headache. Several cellular actions of caffeine have been observed, but it is not entirely clear how each contributes to its pharmacological profile. Among the most important are inhibition of cyclic nucleotide PHOSPHODIESTERASES, antagonism of ADENOSINE RECEPTORS, and modulation of intracellular calcium handling. [MeSH]

Compound Research Comparison

Studies
(kw 2189)
Trials
(kw 2189)
Recent Studies (post-2010)
(kw 2189)
Studies
(caffeine)
Trials
(caffeine)
Recent Studies (post-2010) (caffeine)
104025,5012,3936,825

Protein Interaction Comparison

ProteinTaxonomykw 2189 (IC50)caffeine (IC50)
AcetylcholinesteraseHomo sapiens (human)7.25

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Arioka, H; Fukuoka, K; Ishida, T; Nishio, K; Ogasawara, H; Saijo, N1

Other Studies

1 other study(ies) available for kw 2189 and caffeine

ArticleYear
In vitro enhancement of antitumor activity of a water-soluble duocarmycin derivative, KW-2189, by caffeine-mediated DNA-repair inhibition in human lung cancer cells.
    Japanese journal of cancer research : Gann, 1997, Volume: 88, Issue:11

    Topics: Antineoplastic Combined Chemotherapy Protocols; Caffeine; Carcinoma, Non-Small-Cell Lung; DNA Damage; DNA, Neoplasm; Drug Synergism; Duocarmycins; Humans; Lung Neoplasms; Pyrrolidinones; Solubility; Water

1997