Compounds > kt 5823
Page last updated: 2024-09-02

kt 5823 and sildenafil citrate

kt 5823 has been researched along with sildenafil citrate in 5 studies

Compound Research Comparison

Studies
(kt 5823)		Trials
(kt 5823)		Recent Studies (post-2010)
(kt 5823)		Studies
(sildenafil citrate)		Trials
(sildenafil citrate)		Recent Studies (post-2010) (sildenafil citrate)
3170595,8629562,319

Protein Interaction Comparison

ProteinTaxonomykt 5823 (IC50)sildenafil citrate (IC50)
cGMP-specific 3',5'-cyclic phosphodiesteraseHomo sapiens (human)0.0036

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's3 (60.00)24.3611
2020's1 (20.00)2.80

Authors

AuthorsStudies
Araiza-Saldaña, CI; Bermúdez-Ocaña, DY; Granados-Soto, V; Pérez-Severiano, F; Reyes-García, G1
Cui, JH; Kim, WM; Yoon, MH1
Jiang, H; Lai, N; Lu, W; Ran, P; Wang, J; Xu, L; Yang, K; Zhang, Y; Zhong, N1
Behmenburg, F; Berger, MM; Dorsch, M; Heinen, A; Hollmann, MW; Huhn, R; Mally, D1
Dibb, KM; Eisner, DA; Hutchings, DC; Madders, GWP; Pearman, CM; Trafford, AW; Woods, LS1

Other Studies

5 other study(ies) available for kt 5823 and sildenafil citrate

ArticleYear
Effect of diabetes on the mechanisms of intrathecal antinociception of sildenafil in rats.
    European journal of pharmacology, 2005, Dec-19, Volume: 527, Issue:1-3

    Topics: Analgesia; Animals; Blood Glucose; Body Weight; Carbazoles; Cyclic GMP-Dependent Protein Kinases; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Formaldehyde; Guanylate Cyclase; Indoles; Injections, Spinal; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxadiazoles; Pain; Pain Measurement; Phosphodiesterase Inhibitors; Piperazines; Potassium Channel Blockers; Purines; Quinoxalines; Rats; Rats, Wistar; Sildenafil Citrate; Streptozocin; Sulfones; Time Factors

2005
Role of PKG-L-type calcium channels in the antinociceptive effect of intrathecal sildenafil.
    Journal of veterinary science, 2010, Volume: 11, Issue:2

    Topics: Animals; Calcium Channel Agonists; Calcium Channels, L-Type; Carbazoles; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Male; Pain; Pain Measurement; Piperazines; Protein Kinase Inhibitors; Purines; Pyrroles; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Sulfones

2010
Sildenafil inhibits hypoxia-induced transient receptor potential canonical protein expression in pulmonary arterial smooth muscle via cGMP-PKG-PPARγ axis.
    American journal of respiratory cell and molecular biology, 2013, Volume: 49, Issue:2

    Topics: Animals; Benzamides; Benzophenones; Carbazoles; Cell Movement; Cell Proliferation; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Gene Expression Regulation; Hypoxia; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphodiesterase 5 Inhibitors; Piperazines; PPAR gamma; Protein Kinase Inhibitors; Pulmonary Artery; Purines; Pyridines; Rats; Rats, Wistar; Signal Transduction; Sildenafil Citrate; Sulfones; TRPC Cation Channels; Tyrosine

2013
Impact of Mitochondrial Ca2+-Sensitive Potassium (mBKCa) Channels in Sildenafil-Induced Cardioprotection in Rats.
    PloS one, 2015, Volume: 10, Issue:12

    Topics: Animals; Body Weight; Calcium; Carbazoles; Cardiotonic Agents; Cyclic GMP; Hemodynamics; Male; Mitochondria, Heart; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Potassium Channel Blockers; Potassium Channels, Calcium-Activated; Rats, Wistar; Sildenafil Citrate

2015
PDE5 Inhibition Suppresses Ventricular Arrhythmias by Reducing SR Ca
    Circulation research, 2021, 09-03, Volume: 129, Issue:6

    Topics: Animals; Calcium; Calcium Signaling; Carbazoles; Cyclic Nucleotide Phosphodiesterases, Type 5; Female; Long QT Syndrome; Phenethylamines; Phosphodiesterase 5 Inhibitors; Potassium Channel Blockers; Protein Kinase Inhibitors; Protein Kinases; Sarcoplasmic Reticulum; Sheep; Sildenafil Citrate; Sodium; Sulfonamides

2021