Page last updated: 2024-09-02

kt 5823 and h 89

kt 5823 has been researched along with h 89 in 19 studies

Compound Research Comparison

Studies
(kt 5823)
Trials
(kt 5823)
Recent Studies (post-2010)
(kt 5823)
Studies
(h 89)
Trials
(h 89)
Recent Studies (post-2010) (h 89)
3170591,6190409

Protein Interaction Comparison

ProteinTaxonomykt 5823 (IC50)h 89 (IC50)
Rho-associated protein kinase 2Homo sapiens (human)1.9504
Ribosomal protein S6 kinase alpha-5Homo sapiens (human)0.12
cAMP-dependent protein kinase catalytic subunit alphaBos taurus (cattle)0.073
cAMP-dependent protein kinase catalytic subunit alpha Mus musculus (house mouse)0.381
cAMP-dependent protein kinase catalytic subunit alphaHomo sapiens (human)0.6365
cAMP-dependent protein kinase catalytic subunit gammaHomo sapiens (human)0.6365
cAMP-dependent protein kinase catalytic subunit betaHomo sapiens (human)0.6365
Ribosomal protein S6 kinase beta-1Homo sapiens (human)0.08
RAC-alpha serine/threonine-protein kinaseHomo sapiens (human)1.9886
RAC-beta serine/threonine-protein kinaseHomo sapiens (human)0.5417
Rho-associated protein kinase 2Rattus norvegicus (Norway rat)0.27
RAC-gamma serine/threonine-protein kinaseHomo sapiens (human)0.3207

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's8 (42.11)18.2507
2000's7 (36.84)29.6817
2010's4 (21.05)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Giuliani, S; Maggi, CA; Santicioli, P1
Archer, S; Cornfield, DN; Reeve, HL; Tolarova, S; Weir, EK1
Emaduddin, M; Liu, GJ; Munekata, E; Takeuchi, H1
Grider, JR; Jin, JG; Makhlouf, GM; Murthy, KS1
Sluka, KA; Willis, WD1
Makhlouf, GM; Murthy, KS1
Chik, CL; Ho, AK; Karpinski, E; Li, B1
Chik, CL; Hashimoto, K; Ho, AK1
Bader, B; Burkhardt, M; Butt, E; Gambaryan, S; Glazova, M; Heermeier, K; Lincoln, TM; Palmetshofer, A; Vollkommer, T; Walter, U1
Herring, N; Paterson, DJ1
Aiello, FB; Brunetti, M; Cerletti, C; Evangelista, V; Manarini, S; Martelli, N; Mascetra, N; Musiani, P1
Libersan, D; Merhi, Y; Rousseau, G1
Karpinski, E; Kline, LW1
Chai, Y; Lin, YF; Mao, X1
Fujikawa, H; Kanno, T; Nagata, T; Nishizaki, T1
Miao, Y; Wang, Z; Yang, XL; Zhang, M; Zhao, WJ1
Bezerra, CN; Carraro-Lacroix, LR; Crajoinas, RO; Dariolli, R; Fonteles, MC; Girardi, AC; Lessa, LM; Malnic, G1
Canella, R; Fesce, R; Martini, M; Rossi, ML1
Canella, R; Fesce, R; Martini, M; Rossi, ML; Rubbini, G1

Other Studies

19 other study(ies) available for kt 5823 and h 89

ArticleYear
CGRP inhibition of electromechanical coupling in the guinea-pig isolated renal pelvis.
    Naunyn-Schmiedeberg's archives of pharmacology, 1995, Volume: 352, Issue:5

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Alkaloids; Animals; Arginine; Calcitonin Gene-Related Peptide; Calcium; Carbazoles; Enzyme Inhibitors; Glyburide; Guinea Pigs; In Vitro Techniques; Indoles; Isoquinolines; Kidney Pelvis; Male; Membrane Potentials; Nitroarginine; Potassium Channels; Ryanodine; Sucrose; Sulfonamides; Terpenes; Tetrodotoxin; Thapsigargin

1995
Oxygen causes fetal pulmonary vasodilation through activation of a calcium-dependent potassium channel.
    Proceedings of the National Academy of Sciences of the United States of America, 1996, Jul-23, Volume: 93, Issue:15

    Topics: Alkaloids; Aminoquinolines; Animals; Carbazoles; Charybdotoxin; Endothelium, Vascular; Enzyme Inhibitors; Female; Fetus; Glyburide; Guanylate Cyclase; Hypoxia; Indoles; Isoquinolines; Membrane Potentials; Models, Cardiovascular; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; Oxygen; Patch-Clamp Techniques; Peptides; Potassium Channel Blockers; Potassium Channels; Pregnancy; Protein Kinase Inhibitors; Pulmonary Artery; Sheep; Sulfonamides; Tetraethylammonium; Tetraethylammonium Compounds; Vasodilation

1996
Multiple intracellular signal transduction pathways mediating inward current produced by the neuropeptide, achatin-I.
    European journal of pharmacology, 1996, Apr-29, Volume: 302, Issue:1-3

    Topics: 1-Methyl-3-isobutylxanthine; Alkaloids; Analysis of Variance; Animals; Carbazoles; Dose-Response Relationship, Drug; Indoles; Isoquinolines; Naphthalenes; Neurons; Neuropeptides; Neurotransmitter Agents; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Protein Kinase C; Protein Kinase Inhibitors; Signal Transduction; Snails; Sulfonamides; Vasodilator Agents

1996
Characterization of PACAP receptors and signaling pathways in rabbit gastric muscle cells.
    The American journal of physiology, 1997, Volume: 272, Issue:6 Pt 1

    Topics: Adenylate Cyclase Toxin; Alkaloids; Aminoquinolines; Animals; Calcium; Carbazoles; Cells, Cultured; Citrulline; Cyclic AMP; Cyclic GMP; Cytosol; Enzyme Inhibitors; GTP-Binding Proteins; Guanylate Cyclase; Indoles; Isoquinolines; Kinetics; Muscle Relaxation; Muscle, Smooth; Neuropeptides; Neurotransmitter Agents; Nifedipine; Nitric Oxide Synthase; Nitroarginine; Pertussis Toxin; Pituitary Adenylate Cyclase-Activating Polypeptide; Protein Kinase Inhibitors; Rabbits; Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide; Receptors, Pituitary Hormone; Signal Transduction; Stomach; Sulfonamides; Vasoactive Intestinal Peptide; Virulence Factors, Bordetella

1997
Increased spinal release of excitatory amino acids following intradermal injection of capsaicin is reduced by a protein kinase G inhibitor.
    Brain research, 1998, Jul-06, Volume: 798, Issue:1-2

    Topics: Alkaloids; Animals; Aspartic Acid; Capsaicin; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Glutamic Acid; Indoles; Injections, Intradermal; Isoquinolines; Male; Rats; Rats, Sprague-Dawley; Spinal Cord; Sulfonamides

1998
Differential regulation of phospholipase A2 (PLA2)-dependent Ca2+ signaling in smooth muscle by cAMP- and cGMP-dependent protein kinases. Inhibitory phosphorylation of PLA2 by cyclic nucleotide-dependent protein kinases.
    The Journal of biological chemistry, 1998, Dec-18, Volume: 273, Issue:51

    Topics: Alkaloids; Animals; Arachidonic Acid; Calcium; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; In Vitro Techniques; Indoles; Intestines; Isoproterenol; Isoquinolines; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Nitroprusside; Phospholipases A; Phospholipases A2; Phosphorylation; Rabbits; Signal Transduction; Sulfonamides; Thionucleotides; Vasoactive Intestinal Peptide

1998
Regulation of the L-type Ca2+ channel current in rat pinealocytes: role of basal phosphorylation.
    Journal of neurochemistry, 1999, Volume: 72, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic beta-Agonists; Alkaloids; Animals; Antifungal Agents; Calcium Channels; Calcium Channels, L-Type; Carbazoles; Cyclic AMP; Cyclic GMP; Enzyme Inhibitors; Indoles; Isoproterenol; Isoquinolines; Male; Marine Toxins; Membrane Potentials; Nerve Tissue Proteins; Norepinephrine; Okadaic Acid; Oxazoles; Patch-Clamp Techniques; Phosphoric Monoester Hydrolases; Phosphorylation; Pineal Gland; Protein Kinase C; Pyrans; Rats; Rats, Sprague-Dawley; Spiro Compounds; Sulfonamides; Sympathomimetics

1999
3',5'-cyclic guanosine monophosphate activates mitogen-activated protein kinase in rat pinealocytes.
    Journal of neurochemistry, 1999, Volume: 73, Issue:2

    Topics: Alkaloids; Animals; Atrial Natriuretic Factor; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Cells, Cultured; Cyclic GMP; Dibutyryl Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Indoles; Isoquinolines; Male; Naphthalenes; Natriuretic Peptide, C-Type; Neurosecretory Systems; Nitroprusside; Phosphodiesterase Inhibitors; Phosphorylation; Pineal Gland; Protein Kinase C; Purinones; Rats; Rats, Sprague-Dawley; Sulfhydryl Reagents; Sulfonamides; Thionucleotides

1999
KT5823 inhibits cGMP-dependent protein kinase activity in vitro but not in intact human platelets and rat mesangial cells.
    The Journal of biological chemistry, 2000, Oct-27, Volume: 275, Issue:43

    Topics: Alkaloids; Animals; Blood Platelets; Carbazoles; Cattle; Cell Adhesion Molecules; Colforsin; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Glomerular Mesangium; Humans; Indoles; Isoquinolines; Microfilament Proteins; Nitric Oxide; Phosphoproteins; Phosphorylation; Rats; Sulfonamides

2000
Nitric oxide-cGMP pathway facilitates acetylcholine release and bradycardia during vagal nerve stimulation in the guinea-pig in vitro.
    The Journal of physiology, 2001, Sep-01, Volume: 535, Issue:Pt 2

    Topics: Acetylcholine; Alkaloids; Animals; Bradycardia; Calcium Channel Blockers; Calcium Channels; Carbachol; Carbazoles; Cardiotonic Agents; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Electric Stimulation; Enzyme Inhibitors; Female; Guanylate Cyclase; Guinea Pigs; Heart Rate; In Vitro Techniques; Indoles; Isoquinolines; Milrinone; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; omega-Conotoxin GVIA; Oxadiazoles; Phosphorylation; Presynaptic Terminals; Quinoxalines; Sinoatrial Node; Sulfonamides; Synaptic Transmission; Tritium; Vagus Nerve

2001
Inhibition of cGMP-dependent protein kinases potently decreases neutrophil spontaneous apoptosis.
    Biochemical and biophysical research communications, 2002, Sep-27, Volume: 297, Issue:3

    Topics: Alkaloids; Apoptosis; Carbazoles; Cells, Cultured; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Humans; Indoles; Isoquinolines; Kinetics; Neutrophils; Phosphodiesterase Inhibitors; Sulfonamides

2002
Differential regulation of P-selectin expression by protein kinase A and protein kinase G in thrombin-stimulated human platelets.
    Thrombosis and haemostasis, 2003, Volume: 89, Issue:2

    Topics: Adenylyl Cyclases; Alkaloids; Blood Platelets; Carbazoles; Cell Adhesion; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation; Humans; Indoles; Isoquinolines; Neutrophils; P-Selectin; Phosphorylation; Platelet Activation; Protein Processing, Post-Translational; Second Messenger Systems; Sulfonamides; Thrombin

2003
Progesterone inhibits gallbladder motility through multiple signaling pathways.
    Steroids, 2005, Volume: 70, Issue:9

    Topics: 17-alpha-Hydroxyprogesterone; 20-alpha-Dihydroprogesterone; Animals; Boron Compounds; Calcium; Carbazoles; Carrier Proteins; Cholecystokinin; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP-Dependent Protein Kinases; Gallbladder; Gallbladder Emptying; Genistein; Guinea Pigs; In Vitro Techniques; Indoles; Isoquinolines; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Nifedipine; Peptide Fragments; Progesterone; Protein Kinase Inhibitors; Signal Transduction; Strontium; Sulfonamides

2005
Dual regulation of the ATP-sensitive potassium channel by caffeine.
    American journal of physiology. Cell physiology, 2007, Volume: 292, Issue:6

    Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenosine Triphosphate; Animals; Caffeine; Carbazoles; Cell Line; Dose-Response Relationship, Drug; Gene Expression Regulation; Humans; Indoles; Insulin; Insulin Secretion; Ion Channel Gating; Islets of Langerhans; Isoquinolines; Muscle, Smooth; Pancreas; Potassium Channels; Protein Isoforms; Purinones; Rats; Sulfonamides

2007
The phosphodiesterase III inhibitor olprinone inhibits hippocampal glutamate release via a cGMP/PKG pathway.
    Neuroscience letters, 2008, Dec-26, Volume: 448, Issue:2

    Topics: Animals; Calcium; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; Imidazoles; In Vitro Techniques; Isoquinolines; Male; Membrane Potentials; Phosphodiesterase 3 Inhibitors; Phosphodiesterase Inhibitors; Potassium; Protein Kinase Inhibitors; Pyramidal Cells; Pyridones; Rats; Rats, Wistar; Receptors, AMPA; Signal Transduction; Sulfonamides

2008
Melatonin potentiates glycine currents through a PLC/PKC signalling pathway in rat retinal ganglion cells.
    The Journal of physiology, 2010, Jul-15, Volume: 588, Issue:Pt 14

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Bridged-Ring Compounds; Calcium; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Egtazic Acid; Estrenes; Glycine; Guanosine Diphosphate; Indoles; Isoquinolines; Male; Maleimides; Melatonin; Norbornanes; Pertussis Toxin; Protein Kinase C; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptor, Melatonin, MT2; Retinal Ganglion Cells; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Tetrahydronaphthalenes; Thiocarbamates; Thiones; Type C Phospholipases

2010
Mechanisms underlying the inhibitory effects of uroguanylin on NHE3 transport activity in renal proximal tubule.
    American journal of physiology. Renal physiology, 2012, Nov-15, Volume: 303, Issue:10

    Topics: Animals; Bicarbonates; Carbazoles; Cell Line; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Isoquinolines; Kidney Tubules, Proximal; Male; Natriuretic Peptides; Protein Kinase Inhibitors; Rats; Rats, Wistar; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; Sulfonamides

2012
The amplitude and inactivation properties of the delayed potassium currents are regulated by protein kinase activity in hair cells of the frog semicircular canals.
    PloS one, 2013, Volume: 8, Issue:7

    Topics: Animals; Cadmium; Calcium; Carbazoles; Cations, Divalent; Hair Cells, Auditory; Ion Transport; Isoquinolines; Membrane Potentials; Patch-Clamp Techniques; Phosphorylation; Potassium; Potassium Channels; Protein Kinase Inhibitors; Protein Kinases; Rana esculenta; Semicircular Canals; Sulfonamides; Time Factors

2013
Forskolin and protein kinase inhibitors differentially affect hair cell potassium currents and transmitter release at the cytoneural junction in the isolated frog labyrinth.
    Neuroscience, 2017, 08-15, Volume: 357

    Topics: Action Potentials; Amphibian Proteins; Animals; Carbazoles; Colforsin; Excitatory Postsynaptic Potentials; Hair Cells, Ampulla; Isoquinolines; Miniature Postsynaptic Potentials; Patch-Clamp Techniques; Potassium; Potassium Channel Blockers; Potassium Channels; Protein Kinase Inhibitors; Rana esculenta; Sulfonamides; Tissue Culture Techniques

2017