kt 5823 has been researched along with cyclic gmp in 201 studies
| Studies (kt 5823) | Trials (kt 5823) | Recent Studies (post-2010) (kt 5823) | Studies (cyclic gmp) | Trials (cyclic gmp) | Recent Studies (post-2010) (cyclic gmp) |
|---|---|---|---|---|---|
| 317 | 0 | 59 | 22,346 | 333 | 4,062 |
| Protein | Taxonomy | kt 5823 (IC50) | cyclic gmp (IC50) |
|---|---|---|---|
| Phosphodiesterase | Bos taurus (cattle) | 0.1 | |
| cGMP-inhibited 3',5'-cyclic phosphodiesterase B | Homo sapiens (human) | 2.4 | |
| cGMP-inhibited 3',5'-cyclic phosphodiesterase A | Homo sapiens (human) | 2.4 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 45 (22.39) | 18.2507 |
| 2000's | 115 (57.21) | 29.6817 |
| 2010's | 36 (17.91) | 24.3611 |
| 2020's | 5 (2.49) | 2.80 |
| Authors | Studies |
|---|---|
| Lincoln, TM; Pryzwansky, KB; Wyatt, TA | 1 |
| McKee, M; Nathanson, JA; Scanlon, C; Scavone, C | 1 |
| Frank, HJ; Hu, RM; Levin, ER; Nazario, B; Pedram, A; Prins, BA; Weber, MA | 1 |
| Eguchi, S; Hirata, Y; Imai, T; Marumo, F | 1 |
| Spector, AA; Stoll, LL | 1 |
| Basson, MD; Hong, F | 1 |
| Clementi, E; Meldolesi, J; Nisticò, G; Riccio, M; Sciorati, C | 1 |
| Komalavilas, P; Lincoln, TM | 1 |
| Dembinsky, A; Ravid, S; Rubin, H | 1 |
| Kanagawa, A; Morita, T; Shimada, Y; Ueki, H | 1 |
| Golombek, DA; Mathur, A; Ralph, MR | 1 |
| Ding, JM; Faiman, LE; Gillette, MU; Liu, C | 1 |
| Loweth, AC; Morgan, NG; Scarpello, JH; Williams, GT | 1 |
| Murad, F | 1 |
| Joyner, RW; Kumar, R; Namiki, T | 1 |
| Okamoto, K; Uemura, Y | 1 |
| Kamisato, S; Okamoto, K; Takami, N; Uemura, Y | 1 |
| Rieks, M; Simmet, T; Syrovets, T; Tippler, B | 1 |
| Grider, JR; Jin, JG; Makhlouf, GM; Murthy, KS | 1 |
| Farrugia, G; Liu, X; Maines, MD; Miller, SM; Rae, JL; Rich, A; Szurszewski, JH | 1 |
| Cohen, A; Fouty, B; Komalavilas, P; Lincoln, TM; McMurtry, IF; Muramatsu, M; Rodman, DM | 1 |
| Majewski, H; van der Zypp, A | 1 |
| Anwyl, R; Rowan, MJ; Wang, Y; Wu, J | 1 |
| Bełtowski, J; Górny, D; Marciniak, A | 1 |
| Gifhorn-Katz, S; Hinke, V; Immenschuh, S; Jungermann, K; Katz, N; Kietzmann, T; Ohlmann, A | 1 |
| De Koster, BM; Elferink, JG | 1 |
| Granger, HJ; Hood, J | 1 |
| Alonso-Galicia, M; Falck, JR; Harder, DR; Roman, RJ; Sun, CW | 1 |
| Allescher, HD; Franck, H; Huber, A; Ruth, P; Schusdziarra, V; Storr, M; Trudrung, P | 1 |
| Polte, T; Schröder, H | 1 |
| Gloor, SM; Pontiggia, L; Winterhalter, K | 1 |
| Makhlouf, GM; Murthy, KS | 1 |
| Chik, CL; Ho, AK; Karpinski, E; Li, B | 1 |
| Kubokawa, M; Kubota, T; Mori, Y; Nakamura, K; Nakaya, S; Sato, F; Yoshioka, Y | 1 |
| Chu, HP; Etgen, AM; Morales, JC | 1 |
| Kaye, DM; Kelly, RA; Wiviott, SD | 1 |
| Amoroso, S; Annunziato, L; Cataldi, M; Colao, AM; D'Alessio, A; Di Renzo, GF; Sarnacchiaro, F; Secondo, A | 1 |
| Geiger, JD; Guo, ZH; Mattson, MP | 1 |
| Chik, CL; Hashimoto, K; Ho, AK | 1 |
| Gong, G; Scholz, PM; Straznicka, M; Weiss, HR; Yan, L | 1 |
| Shahidullah, M; Wilson, WS | 1 |
| Jo, H; Komalavilas, P; Lincoln, TM; Shah, PK | 1 |
| Alonso-Galicia, M; Harder, DR; Hudetz, AG; Roman, RJ; Shen, H | 1 |
| Choi, SH; Chun, BG; Chun, YS; Kang, SW; Shin, KH | 1 |
| Chang, YS; Frangos, JA; Lakshminarayanan, S; Tarbell, JM; Yaccino, JA | 1 |
| Gandhi, A; Huang, MW; Scholz, PM; Weiss, HR; Yan, L | 1 |
| Gawler, DJ; Hodson, N; Jiang, LH; Milligan, CJ; Pearson, HA; Porter, V; Wray, D | 1 |
| Chan, FL; Chan, NW; Huang, Y; Kwan, HY; Yao, X | 1 |
| Gorodeski, GI | 2 |
| Wang, WH | 1 |
| Matsunobu, T; Schacht, J | 1 |
| Johns, RA; Li, D; Shirakami, G; Zhan, X | 1 |
| Bader, B; Burkhardt, M; Butt, E; Gambaryan, S; Glazova, M; Heermeier, K; Lincoln, TM; Palmetshofer, A; Vollkommer, T; Walter, U | 1 |
| Faessen, GH; Giaccia, AJ; Giudice, LC; Kaper, F; Shibata, T; Suen, LF; Sugawara, J; Suh, DS | 1 |
| Horikoshi, T; Miyachi, Y; Sasaki, M; Uchiwa, H | 1 |
| Benishin, CG; Kline, LW; Pang, PK | 1 |
| Garvin, JL; Ortiz, PA | 2 |
| Joyner, RW; Kumar, R; Wagner, MB; Wang, Y | 1 |
| Karlsson, AM; Loitto, VM; Nilsson, HM; Sundqvist, T; Svensson, SP | 1 |
| Hüneke, B; Korth, M; Ruth, P; Wang, GX; Zhou, XB | 1 |
| Antonetti, DA; Gardner, TW; Lakshminarayanan, S; Tarbell, JM | 1 |
| Caldarera, CM; Clô, C; Facchini, A; Fattori, M; Flamigni, F; Giordano, E; Pignatti, C; Stefanelli, C; Tantini, B | 1 |
| Burnett, JC; Eilam, Y; Fixler, R; Hasin, Y; Nir, A; Zhang, DF | 1 |
| Gardner, TW; Lakshminarayanan, S; Tarbell, JM | 1 |
| Amarillo, Y; Moreno, H; Nadal, MS; Rudy, B; Vega-Saenz de Miera, E | 1 |
| Huang, Y; Kwan, H; Yao, X | 1 |
| Minami, K; Nakashima, Y; Sata, T; Segawa, K; Shiga, Y; Shigematsu, A; Shiraishi, M | 1 |
| Ferreyra, GA; Golombek, DA | 1 |
| Decking, UK; Schrader, J; Stumpe, T | 1 |
| Ho-Pao, CL; Leamey, CA; Sur, M | 1 |
| Bruckdorfer, KR; Friebe, A; Koesling, D; Naseem, KM; Sabetkar, M; Tullett, JM | 1 |
| Engel, S; Scholz, P; Weiss, H; Yan, L | 1 |
| Baba, A; Enomoto, R; Lee, E; Matsuda, T; Mori, K; Takuma, K | 1 |
| Herring, N; Paterson, DJ | 1 |
| Adragna, NC; Di Fulvio, M; Lauf, PK | 1 |
| Alsaaty, S; Cowan, MJ; Huang, X; Logun, C; Nanavaty, UB; Pawliczak, R; Shelhamer, JH | 1 |
| Ahern, GP; Jackson, MB; Klyachko, VA | 1 |
| Chan, HC; Chen, ZN; Ho, LS; Jiang, JL; Yu, MK; Zhou, Q | 1 |
| Gainor, JP; Minnear, FL; Morton, CA; Roberts, JT; Vincent, PA | 1 |
| Bader, B; Butt, E; Drueckes, P; Jarchau, T; Palmetshofer, A; Walter, U | 1 |
| Murthy, KS | 2 |
| Huang, Y; Kong, SK; Kwan, HY; Yao, X | 1 |
| Makino, N; Satoh, S | 1 |
| Côté, F; Gallo-Payet, N; Gendron, L; Payet, MD | 1 |
| Nadal, A; Ropero, AB; Soria, B | 1 |
| Curcio, F; Doi, SQ; Lagranha, C; Perrella, G; Sellitti, DF | 1 |
| Hirano, J; Itazawa, S; Kubokawa, M; Nakamura, K | 1 |
| Barman, SA; Han, G; White, RE; Zhu, S | 1 |
| Libersan, D; Merhi, Y; Rousseau, G | 1 |
| Liu, L; Simon, SA | 1 |
| Biermann, T; Culman, J; Gohlke, P; Luther, C; Unger, T; Zhao, Y | 1 |
| Delbecque, JP; Gautron, F; Manière, G; Vanhems, E | 1 |
| Beckman, DL; Liu, L; Mehta, P; Sun, P; Wang, J | 1 |
| Jernigan, NL; Resta, TC; Walker, BR | 1 |
| Sanderson, MJ; Zhang, L | 1 |
| Fukui, H; Horio, S; Kawakami, N; Miyoshi, K | 1 |
| Huang, Y; Ko, WH; Kong, SK; Kwan, HY; Lau, KL; Yao, X | 1 |
| Arai, RJ; Debbas, V; Monteiro, HP; Morais, MS; Oliveira, CJ; Schindler, F; Stern, A; Ventura, AM | 1 |
| Abbott, SM; Gillette, MU; Mitchell, JW; Tischkau, SA; Weber, ET | 1 |
| Bátkai, S; Begg, M; Kunos, G; Lovinger, DM; Mo, FM; Offertaler, L; Pacher, P; Razdan, RK | 1 |
| Chan, SL; Fiscus, RR | 1 |
| De Godoy, M; Li, F; Rattan, S | 1 |
| Bachteeva, VT; Chernigovskaya, EV; Fock, EM; Lavrova, EA; Parnova, RG | 1 |
| Cunha, FQ; Ferreira, SH; Sachs, D | 1 |
| Brayden, JE; Dostmann, WR; Nickl, CK; Okwuchukwuasanya, C; Taylor, MS; Tegge, W | 1 |
| Brading, AF; Deka, DK | 1 |
| He, Y; Lazar, M; Scholz, PM; Tse, J; Weiss, HR; Yan, L; Zhang, Q | 1 |
| Aunis, D; Jouvert, P; Langley, K; Lazaris, A; Revel, MO; Zwiller, J | 1 |
| Díaz-Troya, S; Najib, S; Sánchez-Margalet, V | 1 |
| Keung, W; Man, RY; Vanhoutte, PM | 1 |
| He, Y; Scholz, PM; Tse, J; Weiss, HR; Zhang, Q | 1 |
| del Pilar Gomez, M; Nasi, E | 1 |
| Abdallah, Y; Gkatzoflia, A; Kasseckert, S; Pieper, H; Piper, HM; Schäfer, C; Schäfer, M; Schlüter, KD; Walther, S; Zoga, E | 1 |
| Gomez, Mdel P; Nasi, E | 1 |
| Cheng, CY; Lee, NP; Mruk, DD; Wong, CH | 1 |
| Bianciotti, LG; di Nunzio, A; Hope, SI; Legaz, G; Morgazo, C; Perfume, G; Vatta, MS | 1 |
| Hong, H; Lei, L; Tao, Y; Wang, F; Xia, G; Xie, H; Zhang, M | 1 |
| Ay, B; Iyanoye, A; Pabelick, CM; Prakash, YS; Sieck, GC | 1 |
| Baker, KM; Dostal, DE; Kumar, R; Sanghi, S; Smith, M | 1 |
| Cao, LH; Yang, XL; Yu, YC | 1 |
| Flores-Murrieta, FJ; Granados-Soto, V; Mixcoatl-Zecuatl, T | 1 |
| Keira, N; Kobara, M; Mano, A; Matsubara, H; Matsunaga, S; Nishikawa, S; Okigaki, M; Shiraishi, J; Takahashi, T; Takeda, M; Tatsumi, T | 1 |
| Davidov, T; Grover, GJ; Moalem, J; Scholz, PM; Weiss, HR; Zhang, Q | 1 |
| Gillette, R; Hatcher, NG; Moroz, LL; Sudlow, LC | 1 |
| Granados-Soto, V; Medina-Tato, DA; Ortiz, MI; Palma-Martínez, J; Sarmiento-Heredia, D | 1 |
| Ahmad, S; Ahmed, A; Ahmed, S; Al-Ani, B; Cudmore, M; Hewett, P | 1 |
| Keast, JR; Wanigasekara, Y | 1 |
| Brito, GA; Cunha, FQ; Ferreira, SH; Lotufo, CM; Ribeiro, RA; Sachs, D; Vale, ML | 1 |
| Chen, GH; Huang, Y; Li, H; Lu, MQ; Xu, C; Yi, SH | 1 |
| Li, N; Li, X; Liu, H; Wang, Y; Zhang, H; Zhao, W; Zhou, Q | 1 |
| Cao, X; Chen, YF; Li, P; Lucas, J; Novak, L; Oparil, S; Shi, W | 1 |
| Chen, J; Du, X; Nanamori, M; Ye, RD | 1 |
| Almanza, A; Navarrete, F; Soto, E; Vega, R | 1 |
| De Laurentiis, A; Dees, W; Fernández-Solari, J; McCann, SM; Mohn, C; Prestifilippo, JP; Rettori, V | 1 |
| Anand-Srivastava, MB; Bassil, M | 1 |
| Hattori, T; Kanatsuka, H; Koshida, R; Nagaoka, M; Nara, M; Tamada, T; Tamura, G | 1 |
| Anyadike, C; Katz, E; Scholz, PM; Weiss, HR; Zhang, Q | 1 |
| Ito, S; Katano, T; Mabuchi, T; Matsumura, S; Mishina, M; Okuda-Ashitaka, E; Sakimura, K; Xu, L | 1 |
| Ide, H; Kaneki, H; Kurokawa, M | 1 |
| Klassen, SS; Rabkin, SW; Tsang, MY | 1 |
| Armstrong, GA; Dawson-Scully, K; Kent, C; Robertson, RM; Sokolowski, MB | 1 |
| Bazzara, LG; Cabanillas, AM; Costamagna, ME; Fozzatti, L; Lucero, AM; Masini-Repiso, AM; Pellizas, CG; Vélez, ML | 1 |
| Harada, N; Kubo, N; Shen, J; Takeda-Nakazawa, H; Yamashita, T; Zenner, HP | 1 |
| Burrell, HE; Durham, B; Fraser, WD; Gallagher, JA; McCreavy, DT; Mehat, S; Sharpe, GR; Simpson, AW | 1 |
| Boric, MP; Eller, G; Fernández, IC; González, DR; Ordenes, PP; Treuer, AV | 1 |
| Newland, PL; Yates, P | 1 |
| Ishikawa, T; Nakayama, K; Sunouchi, T; Suzuki, K | 1 |
| Rabkin, SW; Tsang, MY | 1 |
| Cai, CY; Cai, ZX; Gu, XY; Guo, HS; Qi, QH; Shan, LJ; Wang, YX; Yin, XZ | 1 |
| Azuma, H; Hirata, Y; Imamura, M; Sakurada, M; Shichiri, M | 1 |
| Bevilaqua, LR; Cammarota, M; Izquierdo, I; Medina, JH; Rossato, JI; Zinn, CG | 1 |
| Fujikawa, H; Kanno, T; Nagata, T; Nishizaki, T | 1 |
| Aunis, D; Gobaille, S; Romieu, P; Zwiller, J | 1 |
| Abdallah, Y; Gligorievski, D; Kasseckert, SA; Kluger, A; Noll, T; Piper, HM; Sauer, H; Schäfer, C; Schlüter, KD; Tillmann, J | 1 |
| Garvin, JL; Hong, NJ | 1 |
| Cai, ZX; Gu, XY; Guo, HS; Li, J; Wu, TH; Yuan, H | 1 |
| Asada, Y; Hatakeyama, K; Imamura, T; Kitamura, K; Masuyama, H; Sekita, Y; Tsuruda, T | 1 |
| Arendshorst, WJ; Fellner, SK | 1 |
| Armstrong, GA; Dawson-Scully, K; López-Guerrero, JJ; Peña, F; Robertson, RM | 1 |
| Jin, Y; Tian, W; Xi, J; Xu, Z; Zhang, L | 1 |
| Scholz, PM; Tan, T; Weiss, HR | 1 |
| Miao, Y; Wang, Z; Yang, XL; Zhang, M; Zhao, WJ | 1 |
| Cai, CY; Cai, ZX; Guo, HS; Li, P; Qu, CL; Zhang, SY | 1 |
| Chen, BY; Qu, P; Tie, R; Yu, J; Zhu, MZ; Zhu, XX | 1 |
| Chen, SD; Hwang, CS; Tang, CM; Yang, DI | 1 |
| Gorczyca, WA; Moynagh, PN; Nowak, J; Siednienko, J | 1 |
| Chen, BY; Jin, J; Qu, P; Tie, R; Yu, J; Zhu, MZ; Zhu, XX | 1 |
| Huang, WJ; Lin, TY; Lu, CW; Wang, SJ | 1 |
| Chen, XF; Huang, YJ; Lin, DY; Xu, XL; Zhang, W | 1 |
| Carvalho, FB; Ferreira, J; Girardi, BA; Marisco, PC; Mello, CF; Oliveira, MS; Rubin, MA; Tonello, R | 1 |
| Carretero, OA; D'Ambrosio, MA; Falck, JR; Garvin, JL; Peterson, EL; Ren, Y; Wang, H | 1 |
| Eguchi, K; Nakanishi, S; Takagi, H; Takahashi, T; Taoufiq, Z | 1 |
| Pandey, KN; Tripathi, S | 1 |
| Chen, L; Li, J; Nair, N; Nguyen, L; O'Donnell, JM; Pan, J; Sun, J; Xu, Y; Zhang, C; Zhang, H | 1 |
| Bezerra, CN; Carraro-Lacroix, LR; Crajoinas, RO; Dariolli, R; Fonteles, MC; Girardi, AC; Lessa, LM; Malnic, G | 1 |
| Dobrivojević, M; Edemir, B; Forssmann, WG; Hirsch, JR; Kalweit, S; Sinđić, A | 1 |
| Guo, J; He, YG; Sun, YJ; Xi, JK; Xie, YX; Zhang, YD; Zheng, H | 1 |
| Jiang, H; Lai, N; Lu, W; Ran, P; Wang, J; Xu, L; Yang, K; Zhang, Y; Zhong, N | 1 |
| Han, J; Lee, S; Xu, Z | 1 |
| Cisneros-Mejorado, A; Hernández-Soberanis, L; Islas-Carbajal, MC; Sánchez, D | 1 |
| Chirkov, YY; Horowitz, JD; Liu, S; Ngo, DT; Stewart, S | 1 |
| Ren, Y; Weng, G; Wu, L; Yao, X; Zheng, J | 1 |
| Fu, F; Ji, L; Liang, X; Shi, Z; Su, F; Tie, R; Xing, W; Yu, J; Yu, L; Zhang, H; Zhu, M | 1 |
| Kosakai, K; Tsujiuchi, Y; Yoshino, M | 1 |
| Baehr, W; Belcher, J; Biel, M; Butler, MR; Ding, XQ; Ma, H; Michalakis, S; Thapa, A; Yang, F | 1 |
| Cai, ZX; Chen, YW; Cheng, C; Guo, HS; Le, WD; Li, S; Wang, C; Wei, M; Yang, ZF | 1 |
| Lueptow, LM; O'Donnell, JM; Zhan, CG | 1 |
| Hu, Q; Ma, F; Wu, D; Zhu, YZ | 1 |
| Behmenburg, F; Berger, MM; Dorsch, M; Heinen, A; Hollmann, MW; Huhn, R; Mally, D | 1 |
| Gu, Z; Jiao, C; Tian, L; Wang, P; Yang, R | 1 |
| Almanza, A; Andrade, A; Duran, P; Felix, R; Gandini, MA; Kaja, S; Sandoval, A | 1 |
| Gu, J; Lin, P; Lin, Z; Lu, S; Luo, J; Ma, Y; Tian, X; Wang, W; Wang, X; Xiao, F; Xiong, Y; Xu, D; Yang, Q; Yang, Y; Zhang, Y | 1 |
| Abbas, SS; El-Abhar, HS; Mahmoud, HM; Schaalan, MF | 1 |
| Bae, H; Kim, T; Lim, I | 1 |
| Bhargava, P; Janda, J; Schnellmann, RG | 1 |
| Chatterji, R; Khoury, S; Mozzachiodi, R; Salas, E; Wainwright, ML | 1 |
| Güven, C; Parlar, A | 1 |
| Alfayate, A; Bonzón-Kulichenko, E; Campanero, MR; De Backer, J; de la Fuente-Alonso, A; Evangelista, A; Forteza, A; Garcia-Izquierdo, E; González-Valdés, I; López-Maderuelo, D; Martín, CE; Martínez-Martínez, S; Méndez-Olivares, MJ; Mingo, S; Muiño-Mosquera, L; Nistal, JF; Redondo, JM; Ruiz-Rodríguez, MJ; Teixido-Tura, G; Toral, M; Vázquez, J | 1 |
1 review(s) available for kt 5823 and cyclic gmp
| Article | Year |
|---|---|
What are the molecular mechanisms for the antiproliferative effects of nitric oxide and cGMP in vascular smooth muscle?
Topics: Alkaloids; Animals; Carbazoles; Cell Division; Cyclic GMP; Enzyme Inhibitors; Humans; Indoles; Muscle, Smooth, Vascular; Nitric Oxide; Nitroprusside; Protein Kinase Inhibitors; Rats; Second Messenger Systems | 1997 |
200 other study(ies) available for kt 5823 and cyclic gmp
| Article | Year |
|---|---|
KT5823 activates human neutrophils and fails to inhibit cGMP-dependent protein kinase phosphorylation of vimentin.
Topics: Alkaloids; Carbazoles; Cyclic GMP; Electrophoresis; Fluorescent Antibody Technique; Histones; Humans; Indoles; Neutrophils; Oligopeptides; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Vimentin | 1991 |
Atrial natriuretic peptide modulates sodium and potassium-activated adenosine triphosphatase through a mechanism involving cyclic GMP and cyclic GMP-dependent protein kinase.
Topics: Alkaloids; Amiloride; Animals; Atrial Natriuretic Factor; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Activation; Indoles; Kidney Medulla; Male; Nitric Oxide; Ouabain; Pyrroles; Rats; Rats, Sprague-Dawley; Signal Transduction; Sodium; Sodium-Potassium-Exchanging ATPase | 1995 |
Prostaglandin E2 and prostacyclin inhibit the production and secretion of endothelin from cultured endothelial cells.
Topics: Alkaloids; Aminoquinolines; Animals; Aorta; Carbazoles; Cattle; Cell Division; Cells, Cultured; Chloramphenicol O-Acetyltransferase; Cyclic GMP; Dinoprostone; DNA; Dose-Response Relationship, Drug; Endothelins; Endothelium, Vascular; Epoprostenol; Indoles; Kinetics; Muscle, Smooth, Vascular; Protein Biosynthesis; Protein Kinase Inhibitors; RNA, Messenger; SRS-A; Thymidine; Transfection | 1994 |
C-type natriuretic peptide upregulates vascular endothelin type B receptors.
Topics: Alkaloids; Animals; Atrial Natriuretic Factor; Binding, Competitive; Blood Vessels; Carbazoles; Cyclic GMP; Endothelins; Indoles; Male; Natriuretic Agents; Natriuretic Peptide, Brain; Natriuretic Peptide, C-Type; Nerve Tissue Proteins; Polysaccharides; Rats; Rats, Wistar; Receptors, Endothelin; RNA, Messenger; Up-Regulation | 1994 |
Lysophosphatidylcholine causes cGMP-dependent verapamil-sensitive Ca2+ influx in vascular smooth muscle cells.
Topics: Alkaloids; Animals; Aorta, Thoracic; Biological Transport; Calcium; Carbazoles; Cells, Cultured; Cyclic GMP; Fura-2; Indoles; Kinetics; Lysophosphatidylcholines; Muscle, Smooth, Vascular; Protein Kinase Inhibitors; Spectrometry, Fluorescence; Swine; Verapamil | 1993 |
Regulation of human Caco-2 intestinal epithelial brush border enzyme activity by cyclic nucleotides.
Topics: Adenylyl Cyclase Inhibitors; Alkaline Phosphatase; Alkaloids; Bucladesine; Caco-2 Cells; Carbazoles; Cell Line; Colonic Neoplasms; Cyclic AMP; Cyclic GMP; Dibutyryl Cyclic GMP; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Drug Synergism; Enzyme Inhibitors; Epithelium; Guanylate Cyclase; Homeostasis; Humans; Indoles; Intestines; Kinetics; Microvilli; Pyrroles | 1996 |
The type 2 ryanodine receptor of neurosecretory PC12 cells is activated by cyclic ADP-ribose. Role of the nitric oxide/cGMP pathway.
Topics: Adenosine Diphosphate Ribose; Alkaloids; Animals; Biomarkers; Caffeine; Calcium; Calcium Channels; Carbazoles; Cyclic ADP-Ribose; Cyclic GMP; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Indoles; Ionomycin; Muscle Proteins; Neurosecretory Systems; Nitric Oxide; Nitroprusside; PC12 Cells; Penicillamine; Rats; Ryanodine Receptor Calcium Release Channel; S-Nitroso-N-Acetylpenicillamine; Signal Transduction; Terpenes; Thapsigargin | 1996 |
Phosphorylation of the inositol 1,4,5-trisphosphate receptor. Cyclic GMP-dependent protein kinase mediates cAMP and cGMP dependent phosphorylation in the intact rat aorta.
Topics: Alkaloids; Angiotensin II; Animals; Aorta; Calcium Channels; Carbazoles; Colforsin; Cyclic AMP; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Activation; Indoles; Inositol 1,4,5-Trisphosphate Receptors; Male; Nitroprusside; Phosphorylation; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Thionucleotides; Time Factors | 1996 |
Chemoattractant-mediated increases in cGMP induce changes in Dictyostelium myosin II heavy chain-specific protein kinase C activities.
Topics: Alkaloids; Animals; Biological Transport; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Cell Membrane; Chemotactic Factors; Cyclic AMP; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cytoskeleton; Cytosol; Dictyostelium; Enzyme Inhibitors; Indoles; Kinetics; Mutation; Myosin Heavy Chains; Myosins; Phosphorylation; Protozoan Proteins | 1996 |
Stimulation of nitric oxide-cyclic GMP pathway by L-arginine increases the release of hepatic lipase from cultured rat hepatocytes.
Topics: Alkaloids; Animals; Arginine; Carbazoles; Cyclic GMP; Enzyme Inhibitors; Indoles; Lipase; Liver; Methylene Blue; Nitric Oxide; omega-N-Methylarginine; Protein Kinase Inhibitors; Rats | 1996 |
cGMP-dependent protein kinase inhibitors block light-induced phase advances of circadian rhythms in vivo.
Topics: Alkaloids; Animals; Carbazoles; Circadian Rhythm; Cricetinae; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Indoles; Isoquinolines; Light; Male; Mesocricetus; Motor Activity | 1996 |
Coupling of muscarinic cholinergic receptors and cGMP in nocturnal regulation of the suprachiasmatic circadian clock.
Topics: Acetylcholine; Afferent Pathways; Alkaloids; Aminoquinolines; Animals; Atropine; Carbachol; Carbazoles; Cholinergic Agents; Cholinergic Fibers; Circadian Rhythm; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Guanylate Cyclase; Indoles; Muscarinic Antagonists; Nerve Tissue Proteins; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Signal Transduction; Suprachiasmatic Nucleus; Time Factors | 1997 |
Evidence for the involvement of cGMP and protein kinase G in nitric oxide-induced apoptosis in the pancreatic B-cell line, HIT-T15.
Topics: Alkaloids; Animals; Apoptosis; Carbazoles; Cell Line; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dibutyryl Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glutathione; Indoles; Islets of Langerhans; Nitroso Compounds; Oxadiazoles; Quinoxalines; S-Nitrosoglutathione | 1997 |
Effects of cGMP on L-type calcium current of adult and newborn rabbit ventricular cells.
Topics: 1-Methyl-3-isobutylxanthine; Alkaloids; Aminoquinolines; Animals; Animals, Newborn; Calcium; Calcium Channels; Carbazoles; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Female; Glutathione; Guanylate Cyclase; Indoles; Male; Methylene Blue; Myocardium; Nitroso Compounds; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Protein Kinase Inhibitors; Rabbits; S-Nitrosoglutathione; Thionucleotides; Time Factors | 1997 |
Elastin-derived peptide induces monocyte chemotaxis by increasing intracellular cyclic GMP level and activating cyclic GMP dependent protein kinase.
Topics: Alkaloids; Animals; Benzophenanthridines; Carbazoles; Cattle; Chemotaxis, Leukocyte; Cyclic AMP; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Drug Synergism; Elastin; Humans; Indoles; Monocytes; N-Formylmethionine Leucyl-Phenylalanine; Phenanthridines; Time Factors | 1997 |
Involvement of intracellular cyclic GMP and cyclic GMP-dependent protein kinase in alpha-elastin-induced macrophage chemotaxis.
Topics: Alkaloids; Animals; Carbazoles; Cells, Cultured; Chemotaxis; Cyclic AMP; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Elastin; Enzyme Inhibitors; Indoles; Macrophages; N-Formylmethionine Leucyl-Phenylalanine; Protein Kinase Inhibitors; Protein Kinases; Pyrroles; Rats; Rats, Wistar | 1997 |
Plasmin is a potent and specific chemoattractant for human peripheral monocytes acting via a cyclic guanosine monophosphate-dependent pathway.
Topics: Alkaloids; Aminoquinolines; Benzophenanthridines; Binding Sites; Carbazoles; Chemotactic Factors; Chemotaxis; Cyclic GMP; Enzyme Inhibitors; Fibrinolysin; Glyceryl Ethers; Guanylate Cyclase; Humans; Indoles; Lysine; Male; Monocytes; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Organ Specificity; Pertussis Toxin; Phenanthridines; Plasminogen; Protein Kinase C; Signal Transduction; Thionucleotides; Tranexamic Acid; Urokinase-Type Plasminogen Activator; Virulence Factors, Bordetella | 1997 |
Characterization of PACAP receptors and signaling pathways in rabbit gastric muscle cells.
Topics: Adenylate Cyclase Toxin; Alkaloids; Aminoquinolines; Animals; Calcium; Carbazoles; Cells, Cultured; Citrulline; Cyclic AMP; Cyclic GMP; Cytosol; Enzyme Inhibitors; GTP-Binding Proteins; Guanylate Cyclase; Indoles; Isoquinolines; Kinetics; Muscle Relaxation; Muscle, Smooth; Neuropeptides; Neurotransmitter Agents; Nifedipine; Nitric Oxide Synthase; Nitroarginine; Pertussis Toxin; Pituitary Adenylate Cyclase-Activating Polypeptide; Protein Kinase Inhibitors; Rabbits; Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide; Receptors, Pituitary Hormone; Signal Transduction; Stomach; Sulfonamides; Vasoactive Intestinal Peptide; Virulence Factors, Bordetella | 1997 |
Distribution of heme oxygenase and effects of exogenous carbon monoxide in canine jejunum.
Topics: Alkaloids; Animals; Carbazoles; Carbon Monoxide; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dogs; Enzyme Inhibitors; Heme Oxygenase (Decyclizing); Indoles; Isoenzymes; Jejunum; Muscle Contraction; Muscle, Smooth; Potassium Channel Blockers; Potassium Channels; Quinidine | 1998 |
Protein kinase G is not essential to NO-cGMP modulation of basal tone in rat pulmonary circulation.
Topics: Alkaloids; Animals; Blood Pressure; Carbazoles; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Hypertension, Pulmonary; Indoles; Lung; Male; Nitric Oxide; Oxadiazoles; Protein Kinase Inhibitors; Protein Kinases; Pulmonary Circulation; Quinoxalines; Rats; Rats, Sprague-Dawley; Thionucleotides; Vascular Resistance; Vasoconstriction | 1998 |
Effect of cGMP inhibitors on the actions of nitrodilators in rat aorta.
Topics: Alkaloids; Animals; Aorta, Thoracic; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinase Type I; Cyclic GMP-Dependent Protein Kinases; Guanylyl Imidodiphosphate; Indoles; Male; Nitroprusside; Rats; Rats, Sprague-Dawley; Thionucleotides; Vasodilator Agents | 1998 |
Evidence for involvement of the cGMP-protein kinase G signaling system in the induction of long-term depression, but not long-term potentiation, in the dentate gyrus in vitro.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Alkaloids; Animals; Benzoates; Carbazoles; Cyclic GMP; Dentate Gyrus; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; GTP-Binding Proteins; Guanylate Cyclase; Indoles; Long-Term Potentiation; Neurons; Oxadiazoles; Phosphodiesterase Inhibitors; Protein Kinases; Purinones; Quinoxalines; Rats; Receptors, Metabotropic Glutamate; Signal Transduction | 1998 |
The mechanism of Na+, K+-ATPase inhibition by atrial natriuretic factor in rat renal medulla.
Topics: 1-Methyl-3-isobutylxanthine; Alkaloids; Animals; Atrial Natriuretic Factor; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Indoles; Kidney Medulla; Male; Papaverine; Phosphodiesterase Inhibitors; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase | 1998 |
Transcriptional activation of the haem oxygenase-1 gene by cGMP via a cAMP response element/activator protein-1 element in primary cultures of rat hepatocytes.
Topics: Alkaloids; Animals; Carbazoles; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinase Type I; Cyclic GMP-Dependent Protein Kinases; Cycloheximide; Enzyme Induction; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Indoles; Kinetics; Liver; Male; Nitroprusside; Rats; Rats, Wistar; RNA, Messenger; Transcription, Genetic; Transcriptional Activation | 1998 |
The involvement of protein kinase G in stimulation of neutrophil migration by endothelins.
Topics: Alkaloids; Carbazoles; Cell Movement; Cyclic GMP; Cyclic GMP-Dependent Protein Kinase Type I; Cyclic GMP-Dependent Protein Kinases; Electroporation; Endothelins; Enzyme Inhibitors; Humans; In Vitro Techniques; Indoles; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Stimulation, Chemical | 1998 |
Protein kinase G mediates vascular endothelial growth factor-induced Raf-1 activation and proliferation in human endothelial cells.
Topics: Alkaloids; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Cell Division; Cells, Cultured; Cyclic GMP; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Activation; Humans; Indoles; Intercellular Signaling Peptides and Proteins; Lymphokines; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Peptides; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-raf; Signal Transduction; Umbilical Veins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1998 |
Contribution of 20-HETE to the vasodilator actions of nitric oxide in renal arteries.
Topics: Alkaloids; Animals; Arterioles; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Guanylate Cyclase; Hydroxyeicosatetraenoic Acids; Indoles; Male; Nitric Oxide; Nitroprusside; Phenylephrine; Potassium Channels; Rats; Rats, Sprague-Dawley; Renal Artery; Vasoconstrictor Agents; Vasodilation | 1998 |
Protein kinase G expression in the small intestine and functional importance for smooth muscle relaxation.
Topics: Alkaloids; Animals; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Guinea Pigs; Indoles; Intestinal Mucosa; Intestine, Small; Male; Molsidomine; Muscle Relaxation; Muscle, Smooth; Myenteric Plexus; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Polymerase Chain Reaction; Pyrroles; Rats; Rats, Wistar; Thionucleotides | 1998 |
Cyclic AMP mediates endothelial protection by nitric oxide.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclase Inhibitors; Alkaloids; Animals; Carbazoles; Cattle; Cell Line; Cell Survival; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic N-Oxides; Dideoxyadenosine; Endothelium, Vascular; Enzyme Inhibitors; Free Radical Scavengers; Imidazoles; Indoles; Kinetics; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Penicillamine; Pulmonary Artery; Pyrroles; Quinoxalines; S-Nitroso-N-Acetylpenicillamine; Tumor Necrosis Factor-alpha | 1998 |
Inhibition of Na,K-ATPase activity by cGMP is isoform-specific in brain endothelial cells.
Topics: Alkaloids; Animals; Carbazoles; Cerebrovascular Circulation; Cyclic GMP; Cyclic GMP-Dependent Protein Kinase Type I; Cyclic GMP-Dependent Protein Kinases; Endothelium, Vascular; Enzyme Inhibitors; Indoles; Isoenzymes; Kinetics; Mice; Nitric Oxide; Ouabain; Polymerase Chain Reaction; Rats; Recombinant Proteins; Sodium-Potassium-Exchanging ATPase | 1998 |
Differential regulation of phospholipase A2 (PLA2)-dependent Ca2+ signaling in smooth muscle by cAMP- and cGMP-dependent protein kinases. Inhibitory phosphorylation of PLA2 by cyclic nucleotide-dependent protein kinases.
Topics: Alkaloids; Animals; Arachidonic Acid; Calcium; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; In Vitro Techniques; Indoles; Intestines; Isoproterenol; Isoquinolines; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Nitroprusside; Phospholipases A; Phospholipases A2; Phosphorylation; Rabbits; Signal Transduction; Sulfonamides; Thionucleotides; Vasoactive Intestinal Peptide | 1998 |
Regulation of the L-type Ca2+ channel current in rat pinealocytes: role of basal phosphorylation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic beta-Agonists; Alkaloids; Animals; Antifungal Agents; Calcium Channels; Calcium Channels, L-Type; Carbazoles; Cyclic AMP; Cyclic GMP; Enzyme Inhibitors; Indoles; Isoproterenol; Isoquinolines; Male; Marine Toxins; Membrane Potentials; Nerve Tissue Proteins; Norepinephrine; Okadaic Acid; Oxazoles; Patch-Clamp Techniques; Phosphoric Monoester Hydrolases; Phosphorylation; Pineal Gland; Protein Kinase C; Pyrans; Rats; Rats, Sprague-Dawley; Spiro Compounds; Sulfonamides; Sympathomimetics | 1999 |
Activation of inwardly rectifying K+ channel in OK proximal tubule cells involves cGMP-dependent phosphorylation process.
Topics: Alkaloids; Animals; Carbazoles; Cell Line; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cytosol; Dibutyryl Cyclic GMP; Enzyme Inhibitors; Indoles; Kidney Tubules, Proximal; Opossums; Patch-Clamp Techniques; Potassium Channels; Protein Kinase Inhibitors; Pyrroles | 1998 |
Cyclic GMP may potentiate lordosis behaviour by progesterone receptor activation.
Topics: Alkaloids; Animals; Brain; Carbazoles; Cyclic GMP; Drug Interactions; Enzyme Inhibitors; Estrogens; Female; Hormone Antagonists; Indoles; Mifepristone; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Posture; Progesterone; Rats; Rats, Sprague-Dawley; Receptors, Progesterone; Sexual Behavior, Animal | 1999 |
Activation of nitric oxide synthase (NOS3) by mechanical activity alters contractile activity in a Ca2+-independent manner in cardiac myocytes: role of troponin I phosphorylation.
Topics: Actin Cytoskeleton; Alkaloids; Animals; Calcium; Carbazoles; Cardiac Pacing, Artificial; Cell Size; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Activation; Heart Ventricles; In Vitro Techniques; Indoles; Male; Methylene Blue; Myocardial Contraction; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroarginine; Phosphorylation; Rats; Rats, Sprague-Dawley; Troponin I; Ventricular Function | 1999 |
Involvement of phosphodiesterase-cGMP-PKG pathway in intracellular Ca2+ oscillations in pituitary GH3 cells.
Topics: Alkaloids; Animals; Calcium; Carbazoles; Cell Line; Cyclic AMP; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 1; Dibutyryl Cyclic GMP; Enzyme Inhibitors; Indoles; Phosphoric Diester Hydrolases; Pituitary Gland; Protein Kinases; Pyrroles; Vinca Alkaloids | 1999 |
Secreted form of amyloid precursor protein enhances basal glucose and glutamate transport and protects against oxidative impairment of glucose and glutamate transport in synaptosomes by a cyclic GMP-mediated mechanism.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Alkaloids; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Apoptosis; Biological Transport; Carbazoles; Cerebral Cortex; Cyclic GMP; Enzyme Inhibitors; Female; Ferrous Compounds; Glucose; Glutamic Acid; Indoles; Lipid Peroxidation; Neurons; Neurotoxins; Oxidative Stress; Rats; Rats, Sprague-Dawley; Synapses; Synaptosomes; Tritium | 1999 |
3',5'-cyclic guanosine monophosphate activates mitogen-activated protein kinase in rat pinealocytes.
Topics: Alkaloids; Animals; Atrial Natriuretic Factor; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Cells, Cultured; Cyclic GMP; Dibutyryl Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Indoles; Isoquinolines; Male; Naphthalenes; Natriuretic Peptide, C-Type; Neurosecretory Systems; Nitroprusside; Phosphodiesterase Inhibitors; Phosphorylation; Pineal Gland; Protein Kinase C; Purinones; Rats; Rats, Sprague-Dawley; Sulfhydryl Reagents; Sulfonamides; Thionucleotides | 1999 |
Cyclic GMP protein kinase mediates negative metabolic and functional effects of cyclic GMP in control and hypertrophied rabbit cardiac myocytes.
Topics: Alkaloids; Animals; Carbazoles; Cardiomegaly; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Indoles; Myocardium; Oxygen Consumption; Purinones; Rabbits | 1999 |
Atriopeptin, sodium azide and cyclic GMP reduce secretion of aqueous humour and inhibit intracellular calcium release in bovine cultured ciliary epithelium.
Topics: Adenosine Triphosphate; Alkaloids; Animals; Aqueous Humor; Atrial Natriuretic Factor; Calcium; Carbazoles; Cattle; Cells, Cultured; Cyclic GMP; Enzyme Inhibitors; Indoles; Intraocular Pressure; Pigment Epithelium of Eye; Protein Kinase Inhibitors; Pyrroles; Sodium Azide | 1999 |
Activation of mitogen-activated protein kinase pathways by cyclic GMP and cyclic GMP-dependent protein kinase in contractile vascular smooth muscle cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Alkaloids; Animals; Aorta; Carbazoles; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Gene Expression; Indoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Muscle Contraction; Muscle, Smooth, Vascular; p38 Mitogen-Activated Protein Kinases; Platelet-Derived Growth Factor; Protein Serine-Threonine Kinases; Pyrroles; Rats; Rats, Sprague-Dawley; Recombinant Fusion Proteins; Thionucleotides; Time Factors; Transfection; Tumor Necrosis Factor-alpha | 1999 |
Contribution of 20-HETE to vasodilator actions of nitric oxide in the cerebral microcirculation.
Topics: Adenosine; Alkaloids; Amides; Animals; Basilar Artery; Carbazoles; Cerebrovascular Circulation; Cyclic GMP; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; Hydrazines; Hydroxyeicosatetraenoic Acids; Indoles; Male; Microcirculation; Middle Cerebral Artery; Mixed Function Oxygenases; Nitric Oxide; Nitroprusside; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Sulfones; Vasodilation; Vasodilator Agents | 1999 |
Guanosine 5',3'-cyclic monophosphate enhances lipopolysaccharide-induced nitric oxide synthase expression in mixed glial cell cultures of rat.
Topics: Alkaloids; Animals; Carbazoles; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dibutyryl Cyclic GMP; Enzyme Inhibitors; Indoles; Lipopolysaccharides; Neuroglia; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors | 1999 |
Shear-induced increase in hydraulic conductivity in endothelial cells is mediated by a nitric oxide-dependent mechanism.
Topics: Alkaloids; Aminoquinolines; Animals; Carbazoles; Cattle; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; Indoles; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; omega-N-Methylarginine; Penicillamine; Protein Kinase Inhibitors; Protein Kinases; Stress, Mechanical | 2000 |
Cyclic GMP reduces ventricular myocyte stunning after simulated ischemia-reperfusion.
Topics: Alkaloids; Animals; Carbazoles; Cell Size; Cells, Cultured; Cyclic GMP; Enzyme Inhibitors; Heart; Heart Ventricles; Indoles; Myocardial Ischemia; Myocardial Reperfusion; Myocardial Stunning; Myocardium; Phosphoproteins; Phosphorylation; Rabbits | 1999 |
Regulation of cloned cardiac L-type calcium channels by cGMP-dependent protein kinase.
Topics: Alkaloids; Amino Acid Sequence; Animals; Calcium; Calcium Channels, L-Type; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; DNA, Complementary; Enzyme Inhibitors; Indoles; Microinjections; Molecular Sequence Data; Mutation; Myocardium; Oocytes; Patch-Clamp Techniques; Phosphorylation; Protein Kinases; Rabbits; Xenopus | 2000 |
A protein kinase G-sensitive channel mediates flow-induced Ca(2+) entry into vascular endothelial cells.
Topics: Alkaloids; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Carbazoles; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Endothelium, Vascular; Enzyme Inhibitors; Gadolinium; Imidazoles; Indoles; Ion Transport; Male; Nickel; Protein Kinase Inhibitors; Protein Kinases; Rats; Rats, Sprague-Dawley | 2000 |
Role of nitric oxide and cyclic guanosine 3',5'-monophosphate in the estrogen regulation of cervical epithelial permeability.
Topics: Alkaloids; Aminoquinolines; Carbazoles; Cell Membrane Permeability; Cells, Cultured; Cervix Uteri; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Densitometry; Enzyme Inhibitors; Epithelial Cells; Estradiol; Estrogens; Female; Humans; Indoles; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroprusside; Up-Regulation | 2000 |
The cGMP-dependent protein kinase stimulates the basolateral 18-pS K channel of the rat CCD.
Topics: 1-Methyl-3-isobutylxanthine; Alkaloids; Animals; Carbazoles; Cell Membrane; Cyclic AMP; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Indoles; Kidney Cortex; Kidney Tubules, Collecting; Membrane Potentials; Patch-Clamp Techniques; Potassium Channels; Rats; Rats, Sprague-Dawley | 2000 |
Nitric oxide/cyclic GMP pathway attenuates ATP-evoked intracellular calcium increase in supporting cells of the guinea pig cochlea.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenosine Triphosphate; Alkaloids; Animals; Biological Transport; Calcium; Carbazoles; Cell Survival; Cochlea; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Guanylate Cyclase; Guinea Pigs; Homeostasis; In Vitro Techniques; Indoles; Nitric Oxide; Protein Kinase Inhibitors; Protein Kinases; Thionucleotides | 2000 |
Regulation of ciliary beat frequency by the nitric oxide-cyclic guanosine monophosphate signaling pathway in rat airway epithelial cells.
Topics: Alkaloids; Animals; Arginine; Carbazoles; Cells, Cultured; Cilia; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelial Cells; Glutathione; Indoles; Nitric Oxide; Nitric Oxide Donors; Nitroso Compounds; omega-N-Methylarginine; Oxadiazoles; Purinones; Quinoxalines; Rats; S-Nitrosoglutathione; Signal Transduction; Trachea | 2000 |
KT5823 inhibits cGMP-dependent protein kinase activity in vitro but not in intact human platelets and rat mesangial cells.
Topics: Alkaloids; Animals; Blood Platelets; Carbazoles; Cattle; Cell Adhesion Molecules; Colforsin; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Glomerular Mesangium; Humans; Indoles; Isoquinolines; Microfilament Proteins; Nitric Oxide; Phosphoproteins; Phosphorylation; Rats; Sulfonamides | 2000 |
Regulation of insulin-like growth factor-binding protein-1 by nitric oxide under hypoxic conditions.
Topics: Alkaloids; Aminoquinolines; Base Sequence; Binding Sites; Carbazoles; Carcinoma, Hepatocellular; Cell Hypoxia; Conserved Sequence; Cyclic GMP; DNA-Binding Proteins; Enzyme Inhibitors; Gene Expression Regulation; Guanylate Cyclase; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Indoles; Insulin-Like Growth Factor Binding Protein 1; Kinetics; Liver; Liver Neoplasms; Luciferases; Molecular Sequence Data; Nitric Oxide; Nitroprusside; Nuclear Proteins; Protein Biosynthesis; Recombinant Fusion Proteins; Signal Transduction; Transcription Factors; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 2000 |
Up-regulation of tyrosinase gene by nitric oxide in human melanocytes.
Topics: Alkaloids; Carbazoles; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Humans; Indoles; Melanocytes; Monophenol Monooxygenase; Nitric Oxide; Penicillamine; RNA, Messenger; S-Nitroso-N-Acetylpenicillamine; Tyrosine 3-Monooxygenase; Up-Regulation | 2000 |
Parathyroid hormone (PTH) and parathyroid hormone-related protein (PTHrP) relax cholecystokinin-induced tension in guinea pig gallbladder strips.
Topics: Alkaloids; Animals; Calcium Channels; Carbazoles; Cholecystokinin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gallbladder; Guinea Pigs; In Vitro Techniques; Indoles; Male; Nitric Oxide; Parathyroid Hormone; Parathyroid Hormone-Related Protein; Peptides; Proteins; Signal Transduction | 2000 |
Autocrine effects of nitric oxide on HCO(3)(-) transport by rat thick ascending limb.
Topics: Alkaloids; Animals; Arginine; Autocrine Communication; Bicarbonates; Biological Transport; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; In Vitro Techniques; Indoles; Loop of Henle; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley | 2000 |
cGMP-dependent protein kinase mediates stimulation of L-type calcium current by cGMP in rabbit atrial cells.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Alkaloids; Animals; Blotting, Western; Calcium Channels, L-Type; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Heart Atria; Indoles; Isoproterenol; Myocardium; Nitric Oxide Donors; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Rabbits; Stimulation, Chemical; Time Factors | 2000 |
Nitric oxide modulates intracellular translocation of pigment organelles in Xenopus laevis melanophores.
Topics: Alkaloids; Animals; Arginine; Biological Transport; Blotting, Western; Carbazoles; Cells, Cultured; Cyclic GMP; Cytoskeleton; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Guanylate Cyclase; Indoles; Melanophores; Microscopy, Fluorescence; Models, Biological; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Quinoxalines; Signal Transduction; Time Factors; Xenopus laevis | 2000 |
BK(Ca) channel activation by membrane-associated cGMP kinase may contribute to uterine quiescence in pregnancy.
Topics: Alkaloids; Carbazoles; Cell Membrane; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Female; Humans; In Vitro Techniques; Indoles; Large-Conductance Calcium-Activated Potassium Channels; Membrane Potentials; Myometrium; Obstetric Labor, Premature; Patch-Clamp Techniques; Peptides; Platelet Aggregation Inhibitors; Potassium Channels; Potassium Channels, Calcium-Activated; Pregnancy; Thionucleotides; Uterine Contraction | 2000 |
cGMP-dependent ADP depolymerization of actin mediates estrogen increase in cervical epithelial permeability.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Actins; Adenosine Diphosphate; Alkaloids; Aminoquinolines; Carbazoles; Cell Membrane Permeability; Cells, Cultured; Cervix Mucus; Cervix Uteri; Cyclic GMP; Enzyme Inhibitors; Epithelial Cells; Estradiol; Estrogen Antagonists; Female; Humans; In Vitro Techniques; Indoles; Nitric Oxide; Nitroprusside; Polymers; Ribose; Tamoxifen; Vasodilator Agents | 2000 |
Effect of VEGF on retinal microvascular endothelial hydraulic conductivity: the role of NO.
Topics: Alkaloids; Aminoquinolines; Animals; Biological Transport; Body Water; Carbazoles; Cattle; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; Indoles; Lymphokines; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitrites; omega-N-Methylarginine; Permeability; Retinal Vessels; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2000 |
Polyamines, NO and cGMP mediate stimulation of DNA synthesis by tumor necrosis factor and lipopolysaccharide in chick embryo cardiomyocytes.
Topics: Alkaloids; Aminoquinolines; Animals; Carbazoles; Cells, Cultured; Chick Embryo; Cyclic GMP; DNA; Eflornithine; Enzyme Activation; Enzyme Inhibitors; Guanylate Cyclase; Indoles; Lipopolysaccharides; Methylene Blue; Myocardium; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Protein Kinase Inhibitors; Stimulation, Chemical; Tumor Necrosis Factor-alpha | 2001 |
C-type natriuretic peptide has a negative inotropic effect on cardiac myocytes.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Alkaloids; Animals; Calcium; Carbazoles; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Depression, Chemical; Dose-Response Relationship, Drug; Guanylate Cyclase; Indoles; Myocardial Contraction; Myocardium; Natriuretic Peptide, C-Type; Polysaccharides; Radioligand Assay; Rats; Receptors, Atrial Natriuretic Factor | 2001 |
NO Inhibits NaCl absorption by rat thick ascending limb through activation of cGMP-stimulated phosphodiesterase.
Topics: Adenine; Alkaloids; Aminoquinolines; Animals; Arginine; Carbazoles; Cyclic AMP; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Exonucleases; Guanylate Cyclase; Indoles; Kidney Tubules, Distal; Male; Nitric Oxide; Perfusion; Rats; Rats, Sprague-Dawley; Sodium Chloride | 2001 |
Effect of shear stress on the hydraulic conductivity of cultured bovine retinal microvascular endothelial cell monolayers.
Topics: Alkaloids; Aminoquinolines; Animals; Biological Transport; Blood-Retinal Barrier; Body Water; Carbazoles; Cattle; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; Indoles; Nitric Oxide; omega-N-Methylarginine; Retinal Vessels; Stress, Mechanical; Water | 2000 |
Modulation of Kv3 potassium channels expressed in CHO cells by a nitric oxide-activated phosphatase.
Topics: Alkaloids; Animals; Carbazoles; CHO Cells; Cricetinae; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Guanylate Cyclase; Indoles; Membrane Potentials; Methylene Blue; Neuropeptides; Nitric Oxide; Nitric Oxide Donors; Okadaic Acid; Patch-Clamp Techniques; Phosphoprotein Phosphatases; Potassium Channels; Potassium Channels, Voltage-Gated; Protein Kinases; Protein Phosphatase 2; Recombinant Proteins; Shaw Potassium Channels; Transfection | 2001 |
Stretch-sensitive switching among different channel sublevels of an endothelial cation channel.
Topics: Alkaloids; Animals; Aorta; Carbazoles; Cells, Cultured; Cyclic GMP; Electrophysiology; Endothelium, Vascular; Indoles; Ion Channels; Male; Patch-Clamp Techniques; Pressure; Rats; Rats, Sprague-Dawley; Stress, Mechanical | 2001 |
Inhibitory effects of nicorandil on rat mesangial cell proliferation via the protein kinase G pathway.
Topics: Alkaloids; Animals; Carbazoles; Cell Division; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Glomerular Mesangium; Guanylate Cyclase; Indoles; Male; Methylene Blue; Nicorandil; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Wistar; Signal Transduction; Thymidine | 2001 |
Rhythmicity of the cGMP-related signal transduction pathway in the mammalian circadian system.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Alkaloids; Animals; Brain; Carbazoles; Circadian Rhythm; Cricetinae; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Darkness; Enzyme Inhibitors; Indoles; Injections, Intraventricular; Isoenzymes; Light; Male; Mammals; Mesocricetus; Motor Activity; Oxadiazoles; Photoperiod; Quinoxalines; Signal Transduction; Suprachiasmatic Nucleus | 2001 |
Nitric oxide reduces energy supply by direct action on the respiratory chain in isolated cardiomyocytes.
Topics: Adenosine; Alkaloids; Animals; Calcium; Carbazoles; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Electron Transport; Energy Metabolism; Enzyme Inhibitors; Indoles; Molsidomine; Muscle Fibers, Skeletal; Myocardium; NAD; Nitric Oxide; Nitric Oxide Donors; Oxygen Consumption; Penicillamine; Rats; Rats, Wistar; S-Nitroso-N-Acetylpenicillamine | 2001 |
Disruption of retinogeniculate pattern formation by inhibition of soluble guanylyl cyclase.
Topics: Aging; Alkaloids; Animals; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Ferrets; Geniculate Bodies; Guanylate Cyclase; In Vitro Techniques; Indoles; Neuropil; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Presynaptic Terminals; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Retinal Ganglion Cells; Signal Transduction; Synaptophysin | 2001 |
Synergism between nitric oxide and hydrogen peroxide in the inhibition of platelet function: the roles of soluble guanylyl cyclase and vasodilator-stimulated phosphoprotein.
Topics: 1-Methyl-3-isobutylxanthine; Alkaloids; Blood Platelets; Blood Proteins; Carbazoles; Cell Adhesion Molecules; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cytosol; Drug Synergism; Enzyme Inhibitors; Guanylate Cyclase; Humans; Hydrazines; Hydrogen Peroxide; In Vitro Techniques; Indazoles; Indoles; Kinetics; Microfilament Proteins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Phosphoproteins; Phosphoserine; Platelet Aggregation; Platelet Aggregation Inhibitors; Subcellular Fractions; Thrombin | 2001 |
Negative functional effects of cGMP mediated by cGMP protein kinase are reduced in T4 cardiac myocytes.
Topics: Alkaloids; Animals; Carbazoles; Cardiomegaly; Cell Size; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Heart Ventricles; Indoles; Phosphorylation; Rabbits; Thyroxine | 2001 |
Ibudilast attenuates astrocyte apoptosis via cyclic GMP signalling pathway in an in vitro reperfusion model.
Topics: Alkaloids; Animals; Animals, Newborn; Apoptosis; Astrocytes; Carbazoles; Cell Survival; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cytochrome c Group; Dipyridamole; DNA; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hydrogen Peroxide; Indoles; Mitochondria; Pentoxifylline; Peptide Hydrolases; Phosphodiesterase Inhibitors; Purinones; Pyridines; Rats; Rats, Wistar; Reperfusion Injury; Signal Transduction; Theophylline; Vinca Alkaloids | 2001 |
Nitric oxide-cGMP pathway facilitates acetylcholine release and bradycardia during vagal nerve stimulation in the guinea-pig in vitro.
Topics: Acetylcholine; Alkaloids; Animals; Bradycardia; Calcium Channel Blockers; Calcium Channels; Carbachol; Carbazoles; Cardiotonic Agents; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Electric Stimulation; Enzyme Inhibitors; Female; Guanylate Cyclase; Guinea Pigs; Heart Rate; In Vitro Techniques; Indoles; Isoquinolines; Milrinone; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; omega-Conotoxin GVIA; Oxadiazoles; Phosphorylation; Presynaptic Terminals; Quinoxalines; Sinoatrial Node; Sulfonamides; Synaptic Transmission; Tritium; Vagus Nerve | 2001 |
Nitric oxide signaling pathway regulates potassium chloride cotransporter-1 mRNA expression in vascular smooth muscle cells.
Topics: Alkaloids; Aminoquinolines; Animals; Biological Transport; Carbazoles; Cells, Cultured; Cyclic GMP; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Indoles; K Cl- Cotransporters; Muscle, Smooth, Vascular; Nitric Oxide; Nitroprusside; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA Processing, Post-Transcriptional; RNA, Messenger; Signal Transduction; Symporters; Time Factors | 2001 |
p11 expression in human bronchial epithelial cells is increased by nitric oxide in a cGMP-dependent pathway involving protein kinase G activation.
Topics: Alkaloids; Annexin A2; Bronchi; Calcium-Binding Proteins; Carbazoles; Cell Nucleus; Chloramphenicol O-Acetyltransferase; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Genes, Dominant; Genes, jun; Genes, Reporter; Immunoblotting; Indoles; Mutation; Nitric Oxide; Nitrogen Oxides; Plasmids; Promoter Regions, Genetic; Protein Binding; RNA, Messenger; S100 Proteins; Spermine; Thionucleotides; Time Factors; Transcription Factor AP-1; Transfection | 2001 |
cGMP-mediated facilitation in nerve terminals by enhancement of the spike afterhyperpolarization.
Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Alkaloids; Animals; Calcium; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Guanylate Cyclase; Indoles; Ion Channel Gating; Ion Transport; Ionomycin; Isoquinolines; Large-Conductance Calcium-Activated Potassium Channels; Nerve Tissue Proteins; Neuronal Plasticity; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitroprusside; Oxadiazoles; Patch-Clamp Techniques; Photolysis; Pituitary Gland, Posterior; Potassium; Potassium Channels; Potassium Channels, Calcium-Activated; Quinoxalines; Signal Transduction; Sodium; Sodium Channels; Sulfonamides; Thionucleotides | 2001 |
The involvement of HAb18G/CD147 in regulation of store-operated calcium entry and metastasis of human hepatoma cells.
Topics: Alkaloids; Antigens, CD; Antigens, Neoplasm; Antigens, Surface; Avian Proteins; Basigin; Blood Proteins; Blotting, Northern; Calcium; Carbazoles; Carcinoma, Hepatocellular; Cell Adhesion; Cell Line; Cell Movement; Collagen; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; DNA, Complementary; Dose-Response Relationship, Drug; Drug Combinations; Enzyme Inhibitors; Humans; Immunohistochemistry; Indoles; Laminin; Liver Neoplasms; Membrane Glycoproteins; Neoplasm Metastasis; NG-Nitroarginine Methyl Ester; Nickel; Nitric Oxide; Penicillamine; Proteoglycans; Signal Transduction; Thapsigargin; Time Factors; Transfection; Tumor Cells, Cultured | 2001 |
Platelet-conditioned medium increases endothelial electrical resistance independently of cAMP/PKA and cGMP/PKG.
Topics: Alkaloids; Androstadienes; Animals; Blood Platelets; Carbazoles; Cattle; Cells, Cultured; Chromones; Culture Media, Conditioned; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Electric Impedance; Endothelium, Vascular; Enzyme Inhibitors; GTP-Binding Protein alpha Subunits, Gi-Go; Indoles; Lysophospholipids; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphorylation; Pulmonary Artery; Wortmannin | 2001 |
A cGMP-dependent protein kinase assay for high throughput screening based on time-resolved fluorescence resonance energy transfer.
Topics: Alkaloids; Amino Acid Sequence; Automation; Blood Platelets; Blotting, Western; Carbazoles; Cell Adhesion Molecules; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; DNA, Complementary; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enzyme Activation; Humans; Indoles; Jurkat Cells; Microfilament Proteins; Models, Biological; Molecular Sequence Data; Phosphoproteins; Phosphorylation; Protein Binding; Spectrometry, Fluorescence; Time Factors | 2001 |
Activation of phosphodiesterase 5 and inhibition of guanylate cyclase by cGMP-dependent protein kinase in smooth muscle.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Alkaloids; Allosteric Site; Animals; Blotting, Western; Carbazoles; Cattle; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 5; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Guanylate Cyclase; Indoles; Intestine, Small; Marine Toxins; Models, Biological; Muscle, Smooth; Nitroprusside; Oxazoles; Phosphoric Diester Hydrolases; Phosphorylation; Precipitin Tests; Protein Structure, Tertiary; Rabbits; Radioimmunoassay | 2001 |
cGMP abolishes agonist-induced [Ca(2+)](i) oscillations in human bladder epithelial cells.
Topics: Acetylcholine; Alkaloids; Bradykinin; Calcium Signaling; Calcium-Transporting ATPases; Carbazoles; Cell Line; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dipyridamole; Drug Antagonism; Enzyme Inhibitors; Epithelial Cells; Humans; Indoles; Kinetics; Macrocyclic Compounds; Oxazoles; Phosphodiesterase Inhibitors; Urinary Bladder | 2001 |
Intracellular mechanisms of cGMP-mediated regulation of myocardial contraction.
Topics: Alkaloids; Animals; Calcium; Carbazoles; Cyclic GMP; Enzyme Inhibitors; Heart; In Vitro Techniques; Indoles; Male; Myocardial Contraction; Myocardium; Rats; Rats, Wistar; Sarcoplasmic Reticulum; Troponin I | 2001 |
Nitric oxide and cyclic GMP are involved in angiotensin II AT(2) receptor effects on neurite outgrowth in NG108-15 cells.
Topics: Alkaloids; Aminoquinolines; Animals; Carbazoles; Cell Differentiation; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Indoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neurites; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Phosphorylation; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Soluble Guanylyl Cyclase; Tumor Cells, Cultured | 2002 |
A nonclassical estrogen membrane receptor triggers rapid differential actions in the endocrine pancreas.
Topics: Alkaloids; Animals; Binding Sites; Calcium; Carbazoles; Cell Membrane; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dopamine; Enzyme Inhibitors; Epinephrine; Estradiol; Glucagon; Horseradish Peroxidase; Indoles; Insulin; Insulin Secretion; Islets of Langerhans; Male; Mice; Microscopy, Confocal; Norepinephrine; Receptors, Estrogen | 2002 |
Atrial natriuretic factor and C-type natriuretic peptide induce retraction of human thyrocytes in monolayer culture via guanylyl cyclase receptors.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Alkaloids; Analysis of Variance; Animals; Atrial Natriuretic Factor; Carbazoles; Cell Count; Cell Division; Cell Line; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Guanylate Cyclase; Humans; Indoles; Microscopy, Phase-Contrast; Natriuretic Peptide, C-Type; Receptors, Atrial Natriuretic Factor; Signal Transduction; Thyroid Gland | 2002 |
Protein kinase G activates inwardly rectifying K(+) channel in cultured human proximal tubule cells.
Topics: Adult; Algorithms; Alkaloids; Atrial Natriuretic Factor; Carbazoles; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Female; Guanylate Cyclase; Humans; Indoles; Kidney Tubules, Proximal; Microscopy, Electron, Scanning; Patch-Clamp Techniques; Potassium Channels, Inwardly Rectifying; Pyrroles; Stimulation, Chemical | 2002 |
cAMP activates BKCa channels in pulmonary arterial smooth muscle via cGMP-dependent protein kinase.
Topics: Alkaloids; Animals; Carbazoles; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Hypertrophy, Right Ventricular; Indoles; Large-Conductance Calcium-Activated Potassium Channel alpha Subunits; Large-Conductance Calcium-Activated Potassium Channels; Male; Membrane Potentials; Muscle, Smooth, Vascular; Patch-Clamp Techniques; Platelet Aggregation Inhibitors; Potassium Channels, Calcium-Activated; Pulmonary Artery; Rats; Rats, Inbred Strains; Thionucleotides; Vasodilator Agents | 2003 |
Differential regulation of P-selectin expression by protein kinase A and protein kinase G in thrombin-stimulated human platelets.
Topics: Adenylyl Cyclases; Alkaloids; Blood Platelets; Carbazoles; Cell Adhesion; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation; Humans; Indoles; Isoquinolines; Neutrophils; P-Selectin; Phosphorylation; Platelet Activation; Protein Processing, Post-Translational; Second Messenger Systems; Sulfonamides; Thrombin | 2003 |
Modulation of IA currents by capsaicin in rat trigeminal ganglion neurons.
Topics: Alkaloids; Animals; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Capsaicin; Carbazoles; Carcinogens; Cyclic AMP; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cytidine Triphosphate; Electric Stimulation; Enzyme Inhibitors; Indoles; Membrane Potentials; Mice; Mice, Mutant Strains; Neural Inhibition; Neurons, Afferent; Nociceptors; Patch-Clamp Techniques; Phorbol 12,13-Dibutyrate; Potassium; Potassium Channels, Voltage-Gated; Rats; Rats, Sprague-Dawley; Receptors, Drug; Sulfonamides; Trigeminal Ganglion | 2003 |
Contribution of bradykinin and nitric oxide to AT2 receptor-mediated differentiation in PC12 W cells.
Topics: Alkaloids; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Bradykinin; Carbazoles; Cell Count; Cell Differentiation; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Indoles; Neurites; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; PC12 Cells; Rats; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin | 2003 |
Inhibition of ovarian steroidogenesis by cyclic GMP in a fly.
Topics: 1-Methyl-3-isobutylxanthine; Adenine; Alkaloids; Animals; Brain; Calcium Channels; Carbazoles; Colforsin; Cyclic AMP; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Diptera; Ecdysteroids; Female; Indoles; Organ Culture Techniques; Ovary; Phosphodiesterase Inhibitors; Quinazolines; Signal Transduction; Stimulation, Chemical | 2003 |
Effect of nitric oxide on lung surfactant secretion.
Topics: Animals; Carbazoles; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelial Cells; Guanidines; Indoles; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitrogen Oxides; Oxadiazoles; Perfusion; Phosphatidylcholines; Pulmonary Alveoli; Pulmonary Surfactants; Quinoxalines; Rats; Rats, Sprague-Dawley; Spermine | 2003 |
Pulmonary PKG-1 is upregulated following chronic hypoxia.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Alkaloids; Animals; Carbazoles; Chronic Disease; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Immunohistochemistry; Indoles; Lung; Nitric Oxide; Platelet Aggregation Inhibitors; Polycythemia; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Thionucleotides; Up-Regulation; Vascular Resistance; Vasodilation | 2003 |
The role of cGMP in the regulation of rabbit airway ciliary beat frequency.
Topics: Animals; Buffers; Calcium; Calcium Signaling; Carbazoles; Cells, Cultured; Cilia; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Indoles; Ionomycin; Ionophores; Rabbits; Respiratory Mucosa; Trachea | 2003 |
Inhibition of histamine H1 receptor downregulation by KT5823, a protein kinase G inhibitor.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Carbazoles; CHO Cells; Cricetinae; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Down-Regulation; Enzyme Activators; Histamine; Indoles; Isoquinolines; Protein Kinase C; Receptors, Histamine H1; Sulfonamides; Thionucleotides; Time Factors | 2003 |
cGMP stimulates endoplasmic reticulum Ca(2+)-ATPase in vascular endothelial cells.
Topics: Adenosine Triphosphate; Alkaloids; Animals; Aorta, Thoracic; Calcium Signaling; Calcium-Transporting ATPases; Carbazoles; Cells, Cultured; Cyclic GMP; Drug Combinations; Endothelium, Vascular; Enzyme Inhibitors; Indoles; Male; Rats; Rats, Sprague-Dawley; Sarcoplasmic Reticulum | 2003 |
Nitric oxide and cGMP activate the Ras-MAP kinase pathway-stimulating protein tyrosine phosphorylation in rabbit aortic endothelial cells.
Topics: Animals; Aorta; Blotting, Western; Carbazoles; Cyclic GMP; Cytosol; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Free Radicals; Genes, Dominant; Glutathione Transferase; Indoles; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; Nitric Oxide; Nitroprusside; Oxadiazoles; Phosphorylation; Precipitin Tests; Proto-Oncogene Proteins p21(ras); Quinoxalines; Rabbits; S-Nitroso-N-Acetylpenicillamine; Signal Transduction; Transfection; Tyrosine | 2003 |
Circadian clock-controlled regulation of cGMP-protein kinase G in the nocturnal domain.
Topics: Alkaloids; Animals; Behavior, Animal; Carbazoles; Cell Cycle Proteins; Cells, Cultured; Circadian Rhythm; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Darkness; Enzyme Inhibitors; Indoles; Kinetics; Neurons; Nuclear Proteins; Oligodeoxyribonucleotides, Antisense; Period Circadian Proteins; Rats; Running; Suprachiasmatic Nucleus | 2003 |
G protein-coupled endothelial receptor for atypical cannabinoid ligands modulates a Ca2+-dependent K+ current.
Topics: Animals; Arteries; Calcium; Cannabinoids; Carbazoles; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Dronabinol; Electrophysiology; Endothelium; Endothelium, Vascular; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Guanylate Cyclase; Humans; Indoles; Kinetics; Ligands; Male; Membrane Potentials; Oxadiazoles; Patch-Clamp Techniques; Peptides; Pertussis Toxin; Potassium; Potassium Channels; Quinoxalines; Rats; Rats, Sprague-Dawley; Resorcinols; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Umbilical Veins; Vasodilator Agents | 2003 |
Guanylyl cyclase inhibitors NS2028 and ODQ and protein kinase G (PKG) inhibitor KT5823 trigger apoptotic DNA fragmentation in immortalized uterine epithelial cells: anti-apoptotic effects of basal cGMP/PKG.
Topics: Animals; Apoptosis; Carbazoles; Cell Line, Transformed; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; DNA; DNA Fragmentation; Enzyme Inhibitors; Epithelial Cells; Female; Guanylate Cyclase; Indoles; Oxadiazoles; Oxazines; Quinoxalines; Signal Transduction; Uterus | 2003 |
Role of adenylate and guanylate cyclases in beta1-, beta2-, and beta3-adrenoceptor-mediated relaxation of internal anal sphincter smooth muscle.
Topics: Adenine; Adenylyl Cyclases; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Blotting, Western; Carbazoles; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; GTP-Binding Proteins; Guanylate Cyclase; Indoles; Male; Muscle Relaxation; Muscle, Smooth; Oxadiazoles; Procaterol; Pyrroles; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-2; Receptors, Adrenergic, beta-3; Suramin; Xamoterol | 2004 |
Nitric oxide inhibits arginine-vasotocin-induced increase of water osmotic permeability in frog urinary bladder.
Topics: Adenine; Animals; Carbazoles; Cyclic AMP; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Exonucleases; Immunohistochemistry; In Vitro Techniques; Indicators and Reagents; Indoles; Male; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitroprusside; Osmotic Pressure; Permeability; Phosphodiesterase Inhibitors; Rana temporaria; Urinary Bladder; Vasotocin | 2004 |
Peripheral analgesic blockade of hypernociception: activation of arginine/NO/cGMP/protein kinase G/ATP-sensitive K+ channel pathway.
Topics: Adenosine Triphosphate; Analgesics; Animals; Arginine; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dinoprostone; Indoles; Male; Nitric Oxide; Nociceptors; omega-N-Methylarginine; Oxadiazoles; Potassium Channels; Quinoxalines; Rats; Rats, Wistar; Signal Transduction | 2004 |
Inhibition of cGMP-dependent protein kinase by the cell-permeable peptide DT-2 reveals a novel mechanism of vasoregulation.
Topics: Animals; Carbazoles; Cerebral Arteries; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; In Vitro Techniques; Indoles; Male; Rats; Thionucleotides; Vasoconstriction; Vasodilation | 2004 |
Nitric oxide activates glibenclamide-sensitive K+ channels in urinary bladder myocytes through a c-GMP-dependent mechanism.
Topics: Adenosine Triphosphate; Animals; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Glyburide; Guinea Pigs; Indoles; Ion Channel Gating; Male; Membrane Potentials; Molsidomine; Myocytes, Smooth Muscle; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Patch-Clamp Techniques; Potassium Channels; Quinoxalines; Signal Transduction; Urinary Bladder | 2004 |
Cyclic GMP reduces myocardial stunning through non-cyclic GMP protein kinase mechanisms.
Topics: Animals; Blood Pressure; Carbazoles; Coronary Stenosis; Coronary Vessels; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Diastole; Dogs; Dose-Response Relationship, Drug; Heart Rate; Indoles; Infusions, Intravenous; Myocardial Contraction; Myocardial Stunning; Myocytes, Cardiac; Oxygen Consumption; Systole; Time Factors | 2004 |
Modulation of soluble guanylate cyclase activity by phosphorylation.
Topics: Carbazoles; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Humans; Indoles; Muscle, Smooth; Nitric Oxide Donors; Nitroprusside; Okadaic Acid; Phosphoric Monoester Hydrolases; Phosphorylation; Radioimmunoassay; Receptors, Cytoplasmic and Nuclear; Solubility; Soluble Guanylyl Cyclase; Stomach; Thionucleotides | 2004 |
Activation of the cGMP pathway in dopaminergic structures reduces cocaine-induced EGR-1 expression and locomotor activity.
Topics: Animals; Brain; Carbazoles; Central Nervous System Stimulants; Cocaine; Cyclic GMP; Cyclic GMP-Dependent Protein Kinase Type I; Cyclic GMP-Dependent Protein Kinases; DNA-Binding Proteins; Dopamine; Early Growth Response Protein 1; Enzyme Activation; Immediate-Early Proteins; Indoles; Injections, Intraventricular; Male; Motor Activity; Natriuretic Peptide, C-Type; Nerve Tissue Proteins; Rats; Rats, Wistar; RNA, Messenger; Signal Transduction; Synaptosomes; Transcription Factors | 2004 |
eNOS, nNOS, cGMP and protein kinase G mediate the inhibitory effect of pancreastatin, a chromogranin A-derived peptide, on growth and proliferation of hepatoma cells.
Topics: Aminoquinolines; Animals; Arginine; Calcium; Carbazoles; Carcinoma, Hepatocellular; Cell Enlargement; Cell Proliferation; Chromogranin A; Chromogranins; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; DNA; Enzyme Inhibitors; Guanylate Cyclase; Indoles; Isoenzymes; Leucine; Liver; MAP Kinase Signaling System; Nerve Tissue Proteins; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Ornithine; Pancreatic Hormones; Peptides; Phospholipase C beta; Protein Isoforms; Rats; Receptors, Atrial Natriuretic Factor; Spermidine; Thymidine; Time Factors; Type C Phospholipases | 2005 |
Acute impairment of contractile responses by 17beta-estradiol is cAMP and protein kinase G dependent in vascular smooth muscle cells of the porcine coronary arteries.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 8-Bromo Cyclic Adenosine Monophosphate; Adenine; Adenylyl Cyclase Inhibitors; Animals; Carbazoles; Coronary Vessels; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Drug Interactions; Estradiol; Indoles; Isometric Contraction; Isoproterenol; Muscle, Smooth, Vascular; Swine; Thionucleotides; Time Factors | 2005 |
Cyclic GMP signaling and regulation of SERCA activity during cardiac myocyte contraction.
Topics: Animals; Calcium-Binding Proteins; Calcium-Transporting ATPases; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Activation; Indoles; Myocardial Contraction; Myocytes, Cardiac; Rabbits; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Second Messenger Systems; Thapsigargin | 2005 |
Calcium-independent, cGMP-mediated light adaptation in invertebrate ciliary photoreceptors.
Topics: Adaptation, Physiological; Animals; Calcium; Carbazoles; Cilia; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Feedback, Physiological; Indoles; Mollusca; Patch-Clamp Techniques; Photic Stimulation; Photoreceptor Cells, Invertebrate; Protein Kinase Inhibitors; Second Messenger Systems | 2005 |
Mechanism of cGMP-mediated protection in a cellular model of myocardial reperfusion injury.
Topics: Animals; Calcium; Calcium-Transporting ATPases; Carbazoles; Cell Size; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cytosol; Hydrogen-Ion Concentration; Indoles; Male; Microscopy, Fluorescence; Myocardial Reperfusion Injury; Myocytes, Cardiac; Rats; Rats, Wistar; Sarcoplasmic Reticulum; Thapsigargin | 2005 |
On the gating mechanisms of the light-dependent conductance in Pecten hyperpolarizing photoreceptors: does light remove inactivation in voltage-dependent K channels?
Topics: Animals; Carbazoles; Cyclic GMP; Indoles; Ion Channel Gating; Light; Membrane Potentials; Mollusca; Photic Stimulation; Photoreceptor Cells, Invertebrate; Potassium Channels, Voltage-Gated; Protein Kinase Inhibitors; Stimulation, Chemical; Vision, Ocular | 2005 |
Regulation of Sertoli-germ cell adherens junction dynamics in the testis via the nitric oxide synthase (NOS)/cGMP/protein kinase G (PRKG)/beta-catenin (CATNB) signaling pathway: an in vitro and in vivo study.
Topics: Adherens Junctions; Animals; beta Catenin; Carbazoles; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cytoskeletal Proteins; Gene Expression Regulation; Hydrazines; Indazoles; Indoles; Male; Nitric Oxide Synthase; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sertoli Cells; Signal Transduction; Spermatozoa; Trans-Activators | 2005 |
Involvement of nitric oxide pathways in short term modulation of tyrosine hydroxylase activity by endothelins 1 and 3 in the rat anterior hypothalamus.
Topics: Animals; Carbazoles; Cyclic GMP; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Endothelin-3; Hypothalamus, Anterior; Indazoles; Indoles; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type I; Nitroprusside; Oligopeptides; Oxadiazoles; Piperidines; Quinoxalines; Rats; Suramin; Tyrosine 3-Monooxygenase | 2005 |
Atrial natriuretic peptide negatively regulates follicle-stimulating hormone-induced porcine oocyte maturation and cumulus expansion via cGMP-dependent protein kinase pathway.
Topics: Animals; Atrial Natriuretic Factor; Carbazoles; Cells, Cultured; Culture Media; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Female; Follicle Stimulating Hormone; Indoles; Meiosis; Oocytes; Ovarian Follicle; Peptide Fragments; Swine | 2005 |
Cyclic nucleotide regulation of store-operated Ca2+ influx in airway smooth muscle.
Topics: Animals; Calcium; Calcium Channels; Carbazoles; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Indoles; Muscle, Smooth; Pyrroles; Swine; Trachea | 2006 |
Activation of protein kinase A by atrial natriuretic peptide in neonatal rat cardiac fibroblasts: role in regulation of the local renin-angiotensin system.
Topics: Angiotensin II; Angiotensinogen; Animals; Animals, Newborn; Atrial Natriuretic Factor; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Fibroblasts; Gene Expression Regulation; Indoles; Myocardium; Protein Kinase Inhibitors; Rats; Renin; Renin-Angiotensin System; RNA, Messenger; Up-Regulation | 2005 |
Modulation by brain natriuretic peptide of GABA receptors on rat retinal ON-type bipolar cells.
Topics: Animals; Atrial Natriuretic Factor; Caffeine; Calcium; Calcium Channels; Calcium Signaling; Calcium-Transporting ATPases; Calmodulin; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Guanylate Cyclase; Heparin; Imidazoles; Indoles; Inositol 1,4,5-Trisphosphate Receptors; Macrocyclic Compounds; Male; Membrane Potentials; Natriuretic Peptide, Brain; Oxazoles; Patch-Clamp Techniques; Peptide Fragments; Peptides, Cyclic; Polysaccharides; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Atrial Natriuretic Factor; Receptors, Cytoplasmic and Nuclear; Receptors, GABA; Receptors, GABA-A; Retinal Bipolar Cells; Ruthenium Red; Ryanodine; Ryanodine Receptor Calcium Release Channel; Thapsigargin | 2006 |
The nitric oxide-cyclic GMP-protein kinase G-K+ channel pathway participates in the antiallodynic effect of spinal gabapentin.
Topics: Amines; Analgesics; Animals; Apamin; Carbazoles; Charybdotoxin; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclohexanecarboxylic Acids; Diazoxide; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Gabapentin; gamma-Aminobutyric Acid; Glyburide; Indazoles; Indoles; Injections, Spinal; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Okadaic Acid; Oxadiazoles; Pain; Pinacidil; Potassium Channel Blockers; Potassium Channels; Protein Kinase Inhibitors; Quinoxalines; Rats; Rats, Wistar; Signal Transduction; Spinal Nerves; Stereoisomerism; Time Factors; Vasodilator Agents | 2006 |
Nicorandil regulates Bcl-2 family proteins and protects cardiac myocytes against hypoxia-induced apoptosis.
Topics: Animals; Animals, Newborn; Apoptosis; Carbazoles; Cation Transport Proteins; Cell Hypoxia; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Indoles; Mitochondria; Myocardium; Myocytes, Cardiac; Nicorandil; Nitric Oxide; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Rats; Signal Transduction; Vasodilator Agents | 2006 |
Negative inotropic effects of C-type natriuretic peptide are attenuated in hypertrophied ventricular myocytes associated with reduced cyclic GMP production.
Topics: Animals; Carbazoles; Cardiomegaly; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Disease Models, Animal; Guanylate Cyclase; Heart Ventricles; Hypertension, Renal; Hypertrophy; Indoles; Myocardial Contraction; Myocytes, Cardiac; Natriuretic Peptide, C-Type; Protein Kinase Inhibitors; Rabbits; Signal Transduction; Surgical Instruments | 2006 |
Nitric oxide potentiates cAMP-gated cation current in feeding neurons of Pleurobranchaea californica independent of cAMP and cGMP signaling pathways.
Topics: Animals; Carbazoles; Cyclic GMP; Diethylamines; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Feeding Behavior; Ganglia, Invertebrate; In Vitro Techniques; Indoles; Ion Channel Gating; Membrane Potentials; Neurons; Nitric Oxide; Oxadiazoles; Patch-Clamp Techniques; Pleurobranchaea; Signal Transduction; Thionucleotides; Time Factors | 2006 |
Possible activation of the NO-cyclic GMP-protein kinase G-K+ channels pathway by gabapentin on the formalin test.
Topics: 4-Aminopyridine; Amines; Analgesics; Animals; Apamin; Carbazoles; Charybdotoxin; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobutyric Acid; Glyburide; Indoles; Naloxone; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain Measurement; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Wistar; Tolbutamide | 2006 |
VEGF-E activates endothelial nitric oxide synthase to induce angiogenesis via cGMP and PKG-independent pathways.
Topics: Animals; Carbazoles; Cell Movement; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Activation; Enzyme Inhibitors; Estrenes; Humans; Indoles; Neovascularization, Physiologic; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Phospholipase C gamma; Phosphorylation; Pyrrolidinones; Signal Transduction; Swine; Vascular Endothelial Growth Factor Receptor-2; Viral Proteins | 2006 |
Nerve growth factor, glial cell line-derived neurotrophic factor and neurturin prevent semaphorin 3A-mediated growth cone collapse in adult sensory neurons.
Topics: Animals; Carbazoles; Cell Count; Cells, Cultured; Cyclic GMP; Diagnostic Imaging; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Ganglia, Spinal; Gene Expression; Glial Cell Line-Derived Neurotrophic Factor; Growth Cones; Immunohistochemistry; Indoles; Male; Nerve Growth Factor; Neurons, Afferent; Neurturin; Rats; Rats, Wistar; Receptors, Nerve Growth Factor; Semaphorins | 2006 |
Peripheral antinociceptive effect of pertussis toxin: activation of the arginine/NO/cGMP/PKG/ ATP-sensitive K channel pathway.
Topics: Adenosine Triphosphate; Analgesia; Analgesics; Animals; Arginine; Bucladesine; Carbazoles; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dinoprostone; Enzyme Inhibitors; Ganglia, Spinal; Glyburide; Indoles; KATP Channels; Male; Neurons; Nitric Oxide; omega-N-Methylarginine; Oxadiazoles; Pain; Pain Measurement; Pertussis Toxin; Potassium Channels, Inwardly Rectifying; Quinoxalines; Rats; Rats, Wistar; Signal Transduction; Tolbutamide | 2006 |
Occurrence of cGMP/nitric oxide-sensitive store-operated calcium entry in fibroblasts and its effect on matrix metalloproteinase secretion.
Topics: Animals; Calcium; Calcium Channels; Carbazoles; Cell Adhesion; Cell Line; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Fibroblasts; Gene Expression Regulation, Enzymologic; Indoles; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Nitric Oxide; RNA, Messenger; S-Nitroso-N-Acetylpenicillamine; Signal Transduction; Thapsigargin | 2006 |
Ginsenoside Re promotes human sperm capacitation through nitric oxide-dependent pathway.
Topics: Acrosome Reaction; Adult; Aminoquinolines; Carbazoles; Cyclic GMP; Ginsenosides; Humans; Indoles; Male; Nitric Oxide; Signal Transduction; Sperm Capacitation; Spermatozoa | 2007 |
ANP signaling inhibits TGF-beta-induced Smad2 and Smad3 nuclear translocation and extracellular matrix expression in rat pulmonary arterial smooth muscle cells.
Topics: Animals; Atrial Natriuretic Factor; Carbazoles; Cell Adhesion Molecules; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Extracellular Matrix Proteins; Gene Expression Regulation; Indoles; Male; Myocytes, Smooth Muscle; Osteopontin; Phosphorylation; Plasminogen Activator Inhibitor 1; Protein Kinase Inhibitors; Protein Transport; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Signal Transduction; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta | 2007 |
Regulation of leukocyte degranulation by cGMP-dependent protein kinase and phosphoinositide 3-kinase: potential roles in phosphorylation of target membrane SNARE complex proteins in rat mast cells.
Topics: Animals; Carbazoles; Cell Degranulation; Cell Line, Tumor; Cell Membrane; Chromones; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Humans; Indoles; Leukocytes; Mast Cells; Membrane Proteins; Morpholines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Rats; Receptors, IgE; SNARE Proteins; Thionucleotides | 2007 |
Modulation of voltage-gated Ca2+ current in vestibular hair cells by nitric oxide.
Topics: Animals; Calcium Channels, L-Type; Carbazoles; Cell Separation; Cyclic GMP; Data Interpretation, Statistical; Enzyme Inhibitors; Ethylmaleimide; Free Radical Scavengers; Hair Cells, Vestibular; In Vitro Techniques; Indoles; Molsidomine; Nitric Oxide; Nitroprusside; Patch-Clamp Techniques; Rats; Rats, Long-Evans; Signal Transduction | 2007 |
Effect of manganese on luteinizing hormone-releasing hormone secretion in adult male rats.
Topics: Age Factors; Animals; Carbazoles; Chlorides; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Female; Gonadotropin-Releasing Hormone; Guanylate Cyclase; Hemoglobins; Hypothalamus; In Vitro Techniques; Indoles; Male; Manganese Compounds; Methylene Blue; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Sex Factors; Signal Transduction | 2007 |
Cyclic GMP modulates the expression of Gi protein and adenylyl cyclase signaling in vascular smooth muscle cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Animals; Aorta; Blood Pressure; Carbazoles; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Gene Expression Regulation; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); Indoles; Muscle, Smooth, Vascular; Rats; Signal Transduction | 2007 |
A potentiating effect of endogenous NO in the physiologic secretion from airway submucosal glands.
Topics: Acetylcholine; Animals; Calcium Signaling; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Exocrine Glands; In Vitro Techniques; Indazoles; Indoles; Models, Biological; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Protein Kinase Inhibitors; Sus scrofa; Trachea | 2007 |
Brain natriuretic peptide reverses the effects of myocardial stunning in rabbit myocardium.
Topics: Animals; Blood Pressure; Carbazoles; Coronary Circulation; Cyclic GMP; Heart Rate; Indoles; Myocardial Contraction; Myocardial Stunning; Natriuretic Peptide, Brain; Oxygen Consumption; Protein Kinase Inhibitors; Rabbits | 2007 |
Nitric oxide (NO) serves as a retrograde messenger to activate neuronal NO synthase in the spinal cord via NMDA receptors.
Topics: Animals; Carbazoles; Cyclic GMP; Dizocilpine Maleate; Indoles; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurons; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase Type I; Piperidines; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 2007 |
The receptor attributable to C-type natriuretic peptide-induced differentiation of osteoblasts is switched from type B- to type C-natriuretic peptide receptor with aging.
Topics: Aging; Animals; Calcium; Carbazoles; Cell Differentiation; Cell Line; Cell Proliferation; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Female; GTP-Binding Proteins; Guanylate Cyclase; Indoles; Natriuretic Peptide, Brain; Natriuretic Peptide, C-Type; Osteoblasts; Pertussis Toxin; Rats; Rats, Wistar; Receptors, Atrial Natriuretic Factor; Signal Transduction | 2008 |
Sodium nitroprusside activates p38 mitogen activated protein kinase through a cGMP/PKG independent mechanism.
Topics: Blotting, Western; Carbazoles; Catalase; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Humans; Imidazoles; Indoles; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Signal Transduction | 2007 |
Natural variation in the thermotolerance of neural function and behavior due to a cGMP-dependent protein kinase.
Topics: Adaptation, Biological; Animals; Behavior, Animal; Cantharidin; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Drosophila melanogaster; Drosophila Proteins; Electromyography; Feeding Behavior; Gene Expression Regulation; Genetic Variation; Hot Temperature; Larva; Locusta migratoria; Male; Neuromuscular Junction; Neurons; Protein Kinase Inhibitors; Protein Phosphatase 2; Synaptic Transmission | 2007 |
Nitric oxide/cGMP signaling inhibits TSH-stimulated iodide uptake and expression of thyroid peroxidase and thyroglobulin mRNA in FRTL-5 thyroid cells.
Topics: Animals; Carbazoles; Cell Line; Cyclic AMP; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Gene Expression; Iodide Peroxidase; Iodides; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Protein Kinase Inhibitors; Rats; RNA, Messenger; Signal Transduction; Thyroglobulin; Thyroid Gland; Thyroid Hormones; Thyrotropin | 2007 |
Hyposmotic stimulation-induced nitric oxide production in outer hair cells of the guinea pig cochlea.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Calcium; Carbazoles; Cell Size; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Gadolinium; Guanylate Cyclase; Guinea Pigs; Hair Cells, Auditory, Outer; Hypotonic Solutions; Indoles; Kinetics; Membrane Potentials; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Organ of Corti; Osmotic Pressure; Phorbol Esters; Potassium; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; S-Nitroso-N-Acetylpenicillamine; Signal Transduction; Sodium Chloride; Suramin; TRPV Cation Channels | 2007 |
Potentiation of ATP- and bradykinin-induced [Ca2+]c responses by PTHrP peptides in the HaCaT cell line.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Bradykinin; Calcium; Carbazoles; Cell Division; Cell Line; Colforsin; Cyclic AMP; Cyclic GMP; Drug Synergism; Humans; Indoles; Keratinocytes; Parathyroid Hormone-Related Protein; Peptide Fragments; Phosphodiesterase Inhibitors; Protein Kinase Inhibitors; Signal Transduction | 2008 |
Differential role of S-nitrosylation and the NO-cGMP-PKG pathway in cardiac contractility.
Topics: Animals; Calcium-Binding Proteins; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclic N-Oxides; Male; Myocardial Contraction; Nitric Oxide; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; S-Nitroso-N-Acetylpenicillamine; Signal Transduction; Spin Labels | 2008 |
Nitrergic modulation of an oviposition digging rhythm in locusts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Behavior, Animal; Carbazoles; Cyclic GMP; Cyclic N-Oxides; Female; Grasshoppers; Guanylate Cyclase; Imidazoles; Indoles; Muscles; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Oviposition; Penicillamine; Protein Kinases; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Soluble Guanylyl Cyclase | 2007 |
Dual effect of nitric oxide on ATP-sensitive K+ channels in rat pancreatic beta cells.
Topics: Adenosine Triphosphate; Animals; Carbazoles; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Diazoxide; Dose-Response Relationship, Drug; Guanylate Cyclase; Insulin; Insulin-Secreting Cells; KATP Channels; Male; Membrane Potentials; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Patch-Clamp Techniques; Protein Kinase Inhibitors; Quinoxalines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Triazenes; Uncoupling Agents | 2008 |
The action of nitric oxide to enhance cell survival in chick cardiomyocytes is mediated through a cGMP and ERK1/2 pathway while p38 mitogen-activated protein kinase-dependent pathways do not alter cell death.
Topics: Animals; Carbazoles; Cell Death; Cell Survival; Cells, Cultured; Chick Embryo; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Flavonoids; Imidazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocytes, Cardiac; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridines; Signal Transduction | 2008 |
Dendroaspis natriuretic peptide relaxes gastric antral circular smooth muscle of guinea-pig through the cGMP/cGMP-dependent protein kinase pathway.
Topics: Animals; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Elapid Venoms; Female; Guinea Pigs; In Vitro Techniques; Intercellular Signaling Peptides and Proteins; Male; Muscle Relaxation; Muscle, Smooth; Patch-Clamp Techniques; Peptides; Potassium Channels, Calcium-Activated; Protein Kinase Inhibitors; Pyloric Antrum; Pyrroles; Signal Transduction | 2008 |
Nitric oxide upregulates dimethylarginine dimethylaminohydrolase-2 via cyclic GMP induction in endothelial cells.
Topics: Amidohydrolases; Animals; Arginine; Carbazoles; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Male; Natriuretic Peptide, C-Type; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitro Compounds; omega-N-Methylarginine; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; RNA, Messenger; S-Nitroso-N-Acetylpenicillamine; Up-Regulation | 2008 |
On the requirement of nitric oxide signaling in the amygdala for consolidation of inhibitory avoidance memory.
Topics: Aminoquinolines; Amygdala; Animals; Anxiety; Arginine; Avoidance Learning; Carbazoles; Cyclic GMP; Enzyme Inhibitors; Exploratory Behavior; Guanylate Cyclase; Male; Maze Learning; Memory; Motor Activity; Nitric Oxide; Nitric Oxide Synthase; Penicillamine; Rats; Rats, Wistar; Signal Transduction | 2009 |
The phosphodiesterase III inhibitor olprinone inhibits hippocampal glutamate release via a cGMP/PKG pathway.
Topics: Animals; Calcium; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; Imidazoles; In Vitro Techniques; Isoquinolines; Male; Membrane Potentials; Phosphodiesterase 3 Inhibitors; Phosphodiesterase Inhibitors; Potassium; Protein Kinase Inhibitors; Pyramidal Cells; Pyridones; Rats; Rats, Wistar; Receptors, AMPA; Signal Transduction; Sulfonamides | 2008 |
Injection of the neuropeptide CNP into dopaminergic rat brain areas decreases alcohol intake.
Topics: Alcohol Drinking; Alcohol-Induced Disorders; Animals; Brain; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dopamine; Ethanol; Humans; Male; Natriuretic Peptide, C-Type; Neuropeptides; Prefrontal Cortex; Rats; Rats, Wistar; Substance Withdrawal Syndrome; Ventral Tegmental Area | 2008 |
Stimulation of cGMP signalling protects coronary endothelium against reperfusion-induced intercellular gap formation.
Topics: Animals; Calcium; Calcium-Binding Proteins; Carbazoles; Cell Hypoxia; Cells, Cultured; Coronary Vessels; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cytosol; Edema, Cardiac; Endoplasmic Reticulum; Endothelial Cells; Enzyme Activators; Gap Junctions; Guanylate Cyclase; Homeostasis; Hydrazines; Male; Myocardial Reperfusion Injury; Myosin Light Chains; ortho-Aminobenzoates; Phosphorylation; Protein Kinase Inhibitors; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Second Messenger Systems; Soluble Guanylyl Cyclase; Sulfonamides; Time Factors | 2009 |
Nitric oxide reduces flow-induced superoxide production via cGMP-dependent protein kinase in thick ascending limbs.
Topics: Animals; Arginine; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 2; Enzyme Inhibitors; Guanylate Cyclase; Loop of Henle; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Renal Circulation; Soluble Guanylyl Cyclase; Superoxides | 2009 |
Effects of Dendroaspis natriuretic peptide on delayed rectifier potassium currents and its mechanism.
Topics: Aminoquinolines; Animals; Carbazoles; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Elapid Venoms; Electrophysiology; Enzyme Inhibitors; Female; Guinea Pigs; Intercellular Signaling Peptides and Proteins; Male; Patch-Clamp Techniques; Peptides; Potassium Channels, Voltage-Gated; Pyrroles; Signal Transduction | 2009 |
Pharmacological stimulation of soluble guanylate cyclase modulates hypoxia-inducible factor-1alpha in rat heart.
Topics: Animals; Animals, Newborn; Carbazoles; Cardiomegaly; Cell Hypoxia; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Disease Models, Animal; Down-Regulation; Enzyme Activation; Enzyme Activators; Guanylate Cyclase; Hypertension; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Myocytes, Cardiac; Neovascularization, Physiologic; Protein Kinase Inhibitors; Pyrazoles; Pyridines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Second Messenger Systems; Soluble Guanylyl Cyclase; Time Factors; Vascular Endothelial Growth Factor A; Ventricular Remodeling | 2009 |
Complex interactions of NO/cGMP/PKG systems on Ca2+ signaling in afferent arteriolar vascular smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; ADP-ribosyl Cyclase; Animals; Arterioles; Calcium; Calcium Signaling; Carbazoles; Cyclic AMP; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Activators; Enzyme Inhibitors; Male; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Peptides; Phosphodiesterase Inhibitors; Potassium Chloride; Quinoxalines; Rats; Rats, Sprague-Dawley | 2010 |
Inhibition of protein kinase G activity protects neonatal mouse respiratory network from hyperthermic and hypoxic stress.
Topics: Action Potentials; Animals; Animals, Newborn; Brain Stem; Carbazoles; Cell Hypoxia; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Fever; In Vitro Techniques; Mice; Mice, Inbred Strains; Microelectrodes; Neurons; Periodicity; Protein Kinase Inhibitors; Respiration; Temperature | 2010 |
Morphine prevents the mitochondrial permeability transition pore opening through NO/cGMP/PKG/Zn2+/GSK-3beta signal pathway in cardiomyocytes.
Topics: Analgesics, Opioid; Animals; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Ethylenediamines; Fluorescent Dyes; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Male; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Models, Animal; Morphine; Myocytes, Cardiac; Nitric Oxide; Rats; Rats, Wistar; Signal Transduction; Zinc | 2010 |
Hypoxia inducible factor-1 improves the negative functional effects of natriuretic peptide and nitric oxide signaling in hypertrophic cardiac myocytes.
Topics: Animals; Carbazoles; Cardiomegaly; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Deferoxamine; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Mice; Mice, Inbred C57BL; Myocytes, Cardiac; Natriuretic Peptide, Brain; Natriuretic Peptide, C-Type; Nitric Oxide; S-Nitroso-N-Acetylpenicillamine; Signal Transduction; Up-Regulation | 2010 |
Melatonin potentiates glycine currents through a PLC/PKC signalling pathway in rat retinal ganglion cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Bridged-Ring Compounds; Calcium; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Egtazic Acid; Estrenes; Glycine; Guanosine Diphosphate; Indoles; Isoquinolines; Male; Maleimides; Melatonin; Norbornanes; Pertussis Toxin; Protein Kinase C; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptor, Melatonin, MT2; Retinal Ganglion Cells; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Tetrahydronaphthalenes; Thiocarbamates; Thiones; Type C Phospholipases | 2010 |
Effect of dendroaspis natriuretic peptide (DNP) on L-type calcium channel current and its pathway.
Topics: Aminoquinolines; Animals; Calcium Channels, L-Type; Carbazoles; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Elapid Venoms; Electrophysiology; Enzyme Inhibitors; Guanylate Cyclase; Guinea Pigs; Intercellular Signaling Peptides and Proteins; Myocytes, Smooth Muscle; Peptides; Purinones; Pyloric Antrum; Radioimmunoassay | 2010 |
Protecting effects of vasonatrin peptide against carbon tetrachloride-induced liver fibrosis.
Topics: Animals; Atrial Natriuretic Factor; Carbazoles; Carbon Tetrachloride; Cell Line; Collagen; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Hepatic Stellate Cells; Liver Cirrhosis; Male; Mice; Mice, Inbred BALB C; Protein Kinase Inhibitors; Rats | 2010 |
Neuroprotective mechanisms of minocycline against sphingomyelinase/ceramide toxicity: Roles of Bcl-2 and thioredoxin.
Topics: Animals; Blotting, Western; Carbazoles; Cells, Cultured; Ceramides; Cyclic GMP; Cyclic GMP-Dependent Protein Kinase Type I; Cyclic GMP-Dependent Protein Kinases; Dinitrochlorobenzene; Genes, bcl-2; Minocycline; Neurons; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Proto-Oncogene Proteins c-bcl-2; Quinoxalines; Rats; Rats, Sprague-Dawley; Signal Transduction; Sphingomyelin Phosphodiesterase; Thioredoxins | 2011 |
Nitric oxide affects IL-6 expression in human peripheral blood mononuclear cells involving cGMP-dependent modulation of NF-κB activity.
Topics: Carbazoles; Cell Nucleus; Cyclic GMP; Cytokines; Genetic Vectors; Humans; Inflammation; Interleukin-6; Leukocytes, Mononuclear; NF-kappa B; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; S-Nitrosoglutathione | 2011 |
Vasonatrin peptide, a new regulator of adiponectin and interleukin-6 production in adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Adiponectin; Animals; Atrial Natriuretic Factor; Carbazoles; Cyclic GMP; Interleukin-6; Mice; Polysaccharides; Receptors, Atrial Natriuretic Factor | 2011 |
Involvement of the cGMP pathway in the osthole-facilitated glutamate release in rat hippocampal nerve endings.
Topics: Animals; Carbazoles; Coumarins; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 5; Glutamic Acid; Guanylate Cyclase; Hippocampus; Male; Nerve Endings; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Thionucleotides | 2012 |
2,3,4',5-tetrahydroxystilbene-2-O-β-D-glucoside inhibits proliferation of vascular smooth muscle cells: involvement of NO/cGMP/PKG pathway.
Topics: Animals; Becaplermin; Carbazoles; Cell Cycle; Cell Proliferation; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Glucosides; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Polygonum; Proto-Oncogene Proteins c-sis; Quinoxalines; Rats; Rats, Sprague-Dawley; Signal Transduction; Stilbenes | 2012 |
Spermidine decreases Na⁺,K⁺-ATPase activity through NMDA receptor and protein kinase G activation in the hippocampus of rats.
Topics: Animals; Biguanides; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dizocilpine Maleate; Enzyme Activation; Hippocampus; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Sodium-Potassium-Exchanging ATPase; Spermidine | 2012 |
Mechanisms of carbon monoxide attenuation of tubuloglomerular feedback.
Topics: Aminoquinolines; Animals; Arterioles; Bucladesine; Carbazoles; Carbon Monoxide; Cyclic AMP; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 2; Enzyme Inhibitors; Feedback, Physiological; Guanylate Cyclase; Imidazoles; In Vitro Techniques; Kidney Glomerulus; Kidney Tubules, Distal; Organometallic Compounds; Rabbits; Triazines | 2012 |
Maturation of a PKG-dependent retrograde mechanism for exoendocytic coupling of synaptic vesicles.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Biophysics; Brain Stem; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclic N-Oxides; Dose-Response Relationship, Drug; Electric Capacitance; Electric Stimulation; Endocytosis; Enzyme Inhibitors; Exocytosis; Gene Expression Regulation, Developmental; Imidazoles; In Vitro Techniques; Membrane Potentials; Nerve Tissue Proteins; Neurons; Patch-Clamp Techniques; Phosphoric Monoester Hydrolases; Rats; Rats, Wistar; Synapses; Synaptic Transmission; Synaptic Vesicles; Synaptophysin; Thionucleotides | 2012 |
Guanylyl cyclase/natriuretic peptide receptor-A signaling antagonizes the vascular endothelial growth factor-stimulated MAPKs and downstream effectors AP-1 and CREB in mouse mesangial cells.
Topics: Animals; Atrial Natriuretic Factor; Carbazoles; Cell Proliferation; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Extracellular Signal-Regulated MAP Kinases; Glomerular Mesangium; MAP Kinase Signaling System; Mice; Protein Kinase Inhibitors; Receptors, Atrial Natriuretic Factor; Second Messenger Systems; Transcription Factor AP-1; Vascular Endothelial Growth Factor A | 2012 |
Phosphodiesterase-2 inhibitor reverses corticosterone-induced neurotoxicity and related behavioural changes via cGMP/PKG dependent pathway.
Topics: Animals; Carbazoles; Cells, Cultured; Corticosterone; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 2; Dose-Response Relationship, Drug; Female; Hippocampus; Imidazoles; Male; Mice; Phosphodiesterase Inhibitors; Pregnancy; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Signal Transduction; Stress, Psychological; Triazines | 2013 |
Mechanisms underlying the inhibitory effects of uroguanylin on NHE3 transport activity in renal proximal tubule.
Topics: Animals; Bicarbonates; Carbazoles; Cell Line; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Isoquinolines; Kidney Tubules, Proximal; Male; Natriuretic Peptides; Protein Kinase Inhibitors; Rats; Rats, Wistar; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; Sulfonamides | 2012 |
Interaction between bradykinin and natriuretic peptides via RGS protein activation in HEK-293 cells.
Topics: Boron Compounds; Bradykinin; Bradykinin B2 Receptor Antagonists; Carbazoles; Chloride Channels; Cyclic GMP; Estrenes; Flow Cytometry; HEK293 Cells; Humans; Inositol 1,4,5-Trisphosphate Receptors; Membrane Potentials; Natriuretic Peptides; Nitrobenzoates; Patch-Clamp Techniques; Potassium Channel Blockers; Protein Kinase Inhibitors; Pyrrolidinones; RGS Proteins; Signal Transduction; Thionucleotides; Type C Phospholipases | 2012 |
[Resveratrol attenuates oxidant-induced mitochondrial damage in embryonic rat cardiomyocytes via inactivating GSK-3β].
Topics: Animals; Carbazoles; Cell Line; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hydrogen Peroxide; Mitochondria, Heart; Myocytes, Cardiac; Oxidants; Rats; Resveratrol; Signal Transduction; Stilbenes | 2012 |
Sildenafil inhibits hypoxia-induced transient receptor potential canonical protein expression in pulmonary arterial smooth muscle via cGMP-PKG-PPARγ axis.
Topics: Animals; Benzamides; Benzophenones; Carbazoles; Cell Movement; Cell Proliferation; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Gene Expression Regulation; Hypoxia; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphodiesterase 5 Inhibitors; Piperazines; PPAR gamma; Protein Kinase Inhibitors; Pulmonary Artery; Purines; Pyridines; Rats; Rats, Wistar; Signal Transduction; Sildenafil Citrate; Sulfones; TRPC Cation Channels; Tyrosine | 2013 |
Dual role of cyclic GMP in cardiac cell survival.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carbazoles; Cell Adhesion Molecules; Cell Line; Cell Survival; Cyclic GMP; Fluorescence; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Insulin; Marine Toxins; Microfilament Proteins; Myocytes, Cardiac; Oxazoles; Phosphoproteins; Phosphorylation; Phosphoserine; Proto-Oncogene Proteins c-akt; Rats | 2013 |
Capacitation and Ca(2+) influx in spermatozoa: role of CNG channels and protein kinase G.
Topics: Animals; Calcium; Calcium Channel Blockers; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclic Nucleotide-Gated Cation Channels; Diltiazem; Ion Transport; Male; Mice; Patch-Clamp Techniques; Protein Kinase Inhibitors; Sperm Capacitation; Spermatozoa | 2014 |
B-Type natriuretic peptide suppression of neutrophil superoxide generation: mechanistic studies in normal subjects.
Topics: Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Humans; N-Formylmethionine Leucyl-Phenylalanine; Natriuretic Peptide, Brain; Neutrophils; Peroxidase; Superoxides; Tetradecanoylphorbol Acetate | 2014 |
Essential role of the cGMP/PKG signaling pathway in regulating the proliferation and survival of human renal carcinoma cells.
Topics: Antineoplastic Agents; Apoptosis; beta Catenin; Carbazoles; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Gene Expression Regulation; Humans; JNK Mitogen-Activated Protein Kinases; Phosphodiesterase 5 Inhibitors; Phosphorylation; Signal Transduction; Sp1 Transcription Factor; Sulindac | 2014 |
Vasonatrin peptide attenuates myocardial ischemia-reperfusion injury in diabetic rats and underlying mechanisms.
Topics: Animals; Apoptosis; Atrial Natriuretic Factor; Carbazoles; Caspase 3; Cell Hypoxia; Cell Line; Creatine Kinase; Cyclic GMP; Cyclic GMP-Dependent Protein Kinase Type I; Diabetes Mellitus, Experimental; Endoplasmic Reticulum Stress; Heart Ventricles; Male; Myocardial Reperfusion Injury; Myocytes, Cardiac; Rats; Rats, Sprague-Dawley; Taurochenodeoxycholic Acid; Transcription Factor CHOP; Ventricular Function | 2015 |
Nitric oxide augments single Ca(2+) channel currents via cGMP-dependent protein kinase in Kenyon cells isolated from the mushroom body of the cricket brain.
Topics: Action Potentials; Animals; Brain; Calcium Channels; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Gryllidae; Male; Mushroom Bodies; Neurons; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Quinoxalines; S-Nitrosoglutathione; Signal Transduction | 2015 |
cGMP/Protein Kinase G Signaling Suppresses Inositol 1,4,5-Trisphosphate Receptor Phosphorylation and Promotes Endoplasmic Reticulum Stress in Photoreceptors of Cyclic Nucleotide-gated Channel-deficient Mice.
Topics: Animals; Apoptosis; Basic-Leucine Zipper Transcription Factors; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclic Nucleotide-Gated Cation Channels; Endoplasmic Reticulum Stress; Ependymoglial Cells; Eye Proteins; Gene Expression Regulation; Guanylate Cyclase; Inositol 1,4,5-Trisphosphate Receptors; Mice; Mice, Knockout; Phosphorylation; Protein Kinase Inhibitors; Receptors, Cell Surface; Retinal Cone Photoreceptor Cells; Signal Transduction; Thionucleotides | 2015 |
Double-Edged Roles of Nitric Oxide Signaling on APP Processing and Amyloid-β Production In Vitro: Preliminary Evidence from Sodium Nitroprusside.
Topics: ADAM Proteins; ADAM10 Protein; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Carbazoles; Cell Line, Tumor; Cyclic GMP; Cyclic N-Oxides; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation; Humans; Imidazoles; Membrane Proteins; Neuroblastoma; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Peroxynitrous Acid; Signal Transduction; Superoxides; Transfection | 2016 |
Cyclic GMP-mediated memory enhancement in the object recognition test by inhibitors of phosphodiesterase-2 in mice.
Topics: Animals; Carbazoles; Cell Adhesion Molecules; Cyclic AMP Response Element-Binding Protein; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 2; Dose-Response Relationship, Drug; Guanylate Cyclase; Imidazoles; Male; Memory; Mice, Inbred ICR; Microfilament Proteins; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxadiazoles; Phosphodiesterase Inhibitors; Phosphoproteins; Protein Kinase Inhibitors; Quinoxalines; Recognition, Psychology; Triazines | 2016 |
Vasorelaxant Effect of a New Hydrogen Sulfide-Nitric Oxide Conjugated Donor in Isolated Rat Aortic Rings through cGMP Pathway.
Topics: Animals; Aorta; Carbazoles; Cardiovascular Diseases; Cell Adhesion Molecules; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Hydrogen Sulfide; Male; Microfilament Proteins; Nitric Oxide; Phosphoproteins; Rats; Rats, Sprague-Dawley; Second Messenger Systems; Vasodilator Agents | 2016 |
Impact of Mitochondrial Ca2+-Sensitive Potassium (mBKCa) Channels in Sildenafil-Induced Cardioprotection in Rats.
Topics: Animals; Body Weight; Calcium; Carbazoles; Cardiotonic Agents; Cyclic GMP; Hemodynamics; Male; Mitochondria, Heart; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Potassium Channel Blockers; Potassium Channels, Calcium-Activated; Rats, Wistar; Sildenafil Citrate | 2015 |
IP3 Mediates Nitric Oxide-Guanosine 3',5'-Cyclic Monophosphate (NO-cGMP)-Induced Isoflavone Accumulation in Soybean Sprouts under UV-B Radiation.
Topics: Acyltransferases; Aminoquinolines; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Glycine max; Inositol 1,4,5-Trisphosphate; Isoflavones; Nitric Oxide; Nitroprusside; Plant Proteins; Seedlings; Ultraviolet Rays | 2016 |
Regulation of L-type Ca
Topics: Animals; Calcium Channels, L-Type; Carbazoles; Cell Line; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; HEK293 Cells; Humans; Insulin; Membrane Potentials; Mutagenesis, Site-Directed; Nitric Oxide; Patch-Clamp Techniques; Phosphorylation; Protein Subunits; Rats; Signal Transduction | 2017 |
Inhibition of Cgkii Suppresses Seizure Activity and Hippocampal Excitation by Regulating the Postsynaptic Delivery of Glua1.
Topics: 4-Aminopyridine; Adolescent; Adult; Animals; Brain; Carbazoles; Child; Cyclic GMP; Cyclic GMP-Dependent Protein Kinase Type II; Disease Models, Animal; Epilepsy; Evoked Potentials; Female; Hippocampus; Humans; Male; Pilocarpine; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Synaptic Transmission; Thionucleotides; Up-Regulation; Young Adult | 2018 |
Involvement of brain natriuretic peptide signaling pathway in the cardioprotective action of sitagliptin.
Topics: Animals; bcl-2-Associated X Protein; Carbazoles; Cardiotonic Agents; Caspase 3; Cyclic GMP; Cyclophilins; Decanoic Acids; Dipeptidyl Peptidase 4; Hemodynamics; Hydroxy Acids; Male; Natriuretic Peptide, Brain; Peptidyl-Prolyl Isomerase F; Proto-Oncogene Proteins c-bcl-2; Rats; Reperfusion Injury; Signal Transduction; Sitagliptin Phosphate | 2018 |
Effects of nitric oxide on apoptosis and voltage-gated calcium channels in human cardiac myofibroblasts.
Topics: Apoptosis; Calcium Channels; Carbazoles; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Fibroblasts; Guanylate Cyclase; Humans; Myofibroblasts; Nitric Oxide; Nitric Oxide Donors; Pyrroles; Signal Transduction | 2020 |
Elucidation of cGMP-dependent induction of mitochondrial biogenesis through PKG and p38 MAPK in the kidney.
Topics: Animals; Carbazoles; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dibenzocycloheptenes; Enzyme Activation; Enzyme Activators; Female; Fluorobenzenes; Formoterol Fumarate; Kidney; Mitochondria; Organelle Biogenesis; p38 Mitogen-Activated Protein Kinases; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phosphorylation; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Rabbits; Signal Transduction | 2020 |
Critical role of protein kinase G in the long-term balance between defensive and appetitive behaviors induced by aversive stimuli in Aplysia.
Topics: Animals; Aplysia; Appetitive Behavior; Behavior, Animal; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Feeding Behavior; Learning; Nitric Oxide; Protein Kinase Inhibitors; Sensory Receptor Cells | 2020 |
Glabridin Relaxes Vascular Smooth Muscles by Activating BK
Topics: 1-Methyl-3-isobutylxanthine; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Endothelium, Vascular; Humans; Ion Channel Gating; Isoflavones; Large-Conductance Calcium-Activated Potassium Channel alpha Subunits; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Peptides; Phenols; Phenylephrine; Phosphodiesterase Inhibitors; Saphenous Vein; Vasodilation | 2021 |
Aortic disease in Marfan syndrome is caused by overactivation of sGC-PRKG signaling by NO.
Topics: Animals; Aorta; Aortic Aneurysm, Thoracic; Biomarkers; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinase Type I; Disease Models, Animal; Female; Fibrillin-1; Gene Knockdown Techniques; Humans; Male; Marfan Syndrome; Mice; Muscle, Smooth, Vascular; Mutation; Myocytes, Smooth Muscle; Nitric Oxide; Nitric Oxide Donors; Primary Cell Culture; Soluble Guanylyl Cyclase; Ultrasonography | 2021 |