kt 5823 has been researched along with 1h-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one in 38 studies
Studies (kt 5823) | Trials (kt 5823) | Recent Studies (post-2010) (kt 5823) | Studies (1h-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one) | Trials (1h-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one) | Recent Studies (post-2010) (1h-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one) |
---|---|---|---|---|---|
317 | 0 | 59 | 793 | 0 | 110 |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 5 (13.16) | 18.2507 |
2000's | 24 (63.16) | 29.6817 |
2010's | 9 (23.68) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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Loweth, AC; Morgan, NG; Scarpello, JH; Williams, GT | 1 |
Cohen, A; Fouty, B; Komalavilas, P; Lincoln, TM; McMurtry, IF; Muramatsu, M; Rodman, DM | 1 |
Anwyl, R; Rowan, MJ; Wang, Y; Wu, J | 1 |
Polte, T; Schröder, H | 1 |
Alonso-Galicia, M; Harder, DR; Hudetz, AG; Roman, RJ; Shen, H | 1 |
Johns, RA; Li, D; Shirakami, G; Zhan, X | 1 |
Karlsson, AM; Loitto, VM; Nilsson, HM; Sundqvist, T; Svensson, SP | 1 |
Ferreyra, GA; Golombek, DA | 1 |
Ho-Pao, CL; Leamey, CA; Sur, M | 1 |
Herring, N; Paterson, DJ | 1 |
Ahern, GP; Jackson, MB; Klyachko, VA | 1 |
Iida, H; Inoue, N; Ishida, H; Ishikawa, Y; Yuan, Z | 1 |
Chanaud, B; Chancerelle, Y; De Sousa, M; Dinh-Xuan, AT; Florentin, I; Giroud, JP; Levacher, M; Mathieu, J; Strzalko, S; Valenti, L | 1 |
Beckman, DL; Liu, L; Mehta, P; Sun, P; Wang, J | 1 |
Arai, RJ; Debbas, V; Monteiro, HP; Morais, MS; Oliveira, CJ; Schindler, F; Stern, A; Ventura, AM | 1 |
Bátkai, S; Begg, M; Kunos, G; Lovinger, DM; Mo, FM; Offertaler, L; Pacher, P; Razdan, RK | 1 |
Chan, SL; Fiscus, RR | 1 |
De Godoy, M; Li, F; Rattan, S | 1 |
Cunha, FQ; Ferreira, SH; Sachs, D | 1 |
Brading, AF; Deka, DK | 1 |
Bianciotti, LG; di Nunzio, A; Hope, SI; Legaz, G; Morgazo, C; Perfume, G; Vatta, MS | 1 |
Araiza-Saldaña, CI; Bermúdez-Ocaña, DY; Granados-Soto, V; Pérez-Severiano, F; Reyes-García, G | 1 |
Flores-Murrieta, FJ; Granados-Soto, V; Mixcoatl-Zecuatl, T | 1 |
Brito, GA; Cunha, FQ; Ferreira, SH; Lotufo, CM; Ribeiro, RA; Sachs, D; Vale, ML | 1 |
Ahmad, S; Ahmed, A; Ahmed, S; Al-Ani, B; Cudmore, M; Fujisawa, T; Hewett, PW | 1 |
Anand-Srivastava, MB; Bassil, M; Li, Y | 1 |
Ishikawa, T; Nakayama, K; Sunouchi, T; Suzuki, K | 1 |
Donat, U; Felix, SB; Frenzel, M; Krieg, T; Kroemer, HK; Maas, O; Rütz, T | 1 |
Anand-Srivastava, MB; Arejian, M; Li, Y | 1 |
Arendshorst, WJ; Fellner, SK | 1 |
Chen, SD; Hwang, CS; Tang, CM; Yang, DI | 1 |
Chen, XF; Huang, YJ; Lin, DY; Xu, XL; Zhang, W | 1 |
Carvalho, FB; Ferreira, J; Girardi, BA; Marisco, PC; Mello, CF; Oliveira, MS; Rubin, MA; Tonello, R | 1 |
Aponte, AM; Kohr, MJ; Murphy, E; Steenbergen, C; Sun, J; Tong, G | 1 |
Kosakai, K; Tsujiuchi, Y; Yoshino, M | 1 |
Lueptow, LM; O'Donnell, JM; Zhan, CG | 1 |
Artinian, L; Estes, S; Rehder, V | 1 |
Bae, H; Bang, H; Choi, J; Kim, JH; Kim, T; Kim, YW; Ko, JH; Lee, D; Lim, I | 1 |
38 other study(ies) available for kt 5823 and 1h-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one
Article | Year |
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Evidence for the involvement of cGMP and protein kinase G in nitric oxide-induced apoptosis in the pancreatic B-cell line, HIT-T15.
Topics: Alkaloids; Animals; Apoptosis; Carbazoles; Cell Line; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dibutyryl Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glutathione; Indoles; Islets of Langerhans; Nitroso Compounds; Oxadiazoles; Quinoxalines; S-Nitrosoglutathione | 1997 |
Protein kinase G is not essential to NO-cGMP modulation of basal tone in rat pulmonary circulation.
Topics: Alkaloids; Animals; Blood Pressure; Carbazoles; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Hypertension, Pulmonary; Indoles; Lung; Male; Nitric Oxide; Oxadiazoles; Protein Kinase Inhibitors; Protein Kinases; Pulmonary Circulation; Quinoxalines; Rats; Rats, Sprague-Dawley; Thionucleotides; Vascular Resistance; Vasoconstriction | 1998 |
Evidence for involvement of the cGMP-protein kinase G signaling system in the induction of long-term depression, but not long-term potentiation, in the dentate gyrus in vitro.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Alkaloids; Animals; Benzoates; Carbazoles; Cyclic GMP; Dentate Gyrus; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; GTP-Binding Proteins; Guanylate Cyclase; Indoles; Long-Term Potentiation; Neurons; Oxadiazoles; Phosphodiesterase Inhibitors; Protein Kinases; Purinones; Quinoxalines; Rats; Receptors, Metabotropic Glutamate; Signal Transduction | 1998 |
Cyclic AMP mediates endothelial protection by nitric oxide.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclase Inhibitors; Alkaloids; Animals; Carbazoles; Cattle; Cell Line; Cell Survival; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic N-Oxides; Dideoxyadenosine; Endothelium, Vascular; Enzyme Inhibitors; Free Radical Scavengers; Imidazoles; Indoles; Kinetics; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Penicillamine; Pulmonary Artery; Pyrroles; Quinoxalines; S-Nitroso-N-Acetylpenicillamine; Tumor Necrosis Factor-alpha | 1998 |
Contribution of 20-HETE to vasodilator actions of nitric oxide in the cerebral microcirculation.
Topics: Adenosine; Alkaloids; Amides; Animals; Basilar Artery; Carbazoles; Cerebrovascular Circulation; Cyclic GMP; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; Hydrazines; Hydroxyeicosatetraenoic Acids; Indoles; Male; Microcirculation; Middle Cerebral Artery; Mixed Function Oxygenases; Nitric Oxide; Nitroprusside; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Sulfones; Vasodilation; Vasodilator Agents | 1999 |
Regulation of ciliary beat frequency by the nitric oxide-cyclic guanosine monophosphate signaling pathway in rat airway epithelial cells.
Topics: Alkaloids; Animals; Arginine; Carbazoles; Cells, Cultured; Cilia; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelial Cells; Glutathione; Indoles; Nitric Oxide; Nitric Oxide Donors; Nitroso Compounds; omega-N-Methylarginine; Oxadiazoles; Purinones; Quinoxalines; Rats; S-Nitrosoglutathione; Signal Transduction; Trachea | 2000 |
Nitric oxide modulates intracellular translocation of pigment organelles in Xenopus laevis melanophores.
Topics: Alkaloids; Animals; Arginine; Biological Transport; Blotting, Western; Carbazoles; Cells, Cultured; Cyclic GMP; Cytoskeleton; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Guanylate Cyclase; Indoles; Melanophores; Microscopy, Fluorescence; Models, Biological; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Quinoxalines; Signal Transduction; Time Factors; Xenopus laevis | 2000 |
Rhythmicity of the cGMP-related signal transduction pathway in the mammalian circadian system.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Alkaloids; Animals; Brain; Carbazoles; Circadian Rhythm; Cricetinae; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Darkness; Enzyme Inhibitors; Indoles; Injections, Intraventricular; Isoenzymes; Light; Male; Mammals; Mesocricetus; Motor Activity; Oxadiazoles; Photoperiod; Quinoxalines; Signal Transduction; Suprachiasmatic Nucleus | 2001 |
Disruption of retinogeniculate pattern formation by inhibition of soluble guanylyl cyclase.
Topics: Aging; Alkaloids; Animals; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Ferrets; Geniculate Bodies; Guanylate Cyclase; In Vitro Techniques; Indoles; Neuropil; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Presynaptic Terminals; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Retinal Ganglion Cells; Signal Transduction; Synaptophysin | 2001 |
Nitric oxide-cGMP pathway facilitates acetylcholine release and bradycardia during vagal nerve stimulation in the guinea-pig in vitro.
Topics: Acetylcholine; Alkaloids; Animals; Bradycardia; Calcium Channel Blockers; Calcium Channels; Carbachol; Carbazoles; Cardiotonic Agents; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Electric Stimulation; Enzyme Inhibitors; Female; Guanylate Cyclase; Guinea Pigs; Heart Rate; In Vitro Techniques; Indoles; Isoquinolines; Milrinone; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; omega-Conotoxin GVIA; Oxadiazoles; Phosphorylation; Presynaptic Terminals; Quinoxalines; Sinoatrial Node; Sulfonamides; Synaptic Transmission; Tritium; Vagus Nerve | 2001 |
cGMP-mediated facilitation in nerve terminals by enhancement of the spike afterhyperpolarization.
Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Alkaloids; Animals; Calcium; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Guanylate Cyclase; Indoles; Ion Channel Gating; Ion Transport; Ionomycin; Isoquinolines; Large-Conductance Calcium-Activated Potassium Channels; Nerve Tissue Proteins; Neuronal Plasticity; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitroprusside; Oxadiazoles; Patch-Clamp Techniques; Photolysis; Pituitary Gland, Posterior; Potassium; Potassium Channels; Potassium Channels, Calcium-Activated; Quinoxalines; Signal Transduction; Sodium; Sodium Channels; Sulfonamides; Thionucleotides | 2001 |
Effect of SNI-2011 on amylase secretion from parotid tissue in rats and in neuronal nitric oxide synthase knockout mice.
Topics: Alkaloids; Amylases; Animals; Azepines; Benzoates; Benzylamines; Calcium; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Carbazoles; Chelating Agents; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Estrenes; Gallic Acid; Genotype; Guanylate Cyclase; Imidazoles; In Vitro Techniques; Indoles; Male; Mice; Mice, Knockout; Molsidomine; Muscarinic Agonists; Myosin-Light-Chain Kinase; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxadiazoles; Parotid Gland; Penicillamine; Phosphodiesterase Inhibitors; Pilocarpine; Protein Kinase Inhibitors; Pyrroles; Pyrrolidinones; Quinoxalines; Quinuclidines; Rats; Rats, Wistar; Sulfonamides; Thiophenes; Type C Phospholipases | 2003 |
Nitric oxide inhibits spleen cell proliferative response after burn injury by inducing cytostasis, apoptosis, and necrosis of activated T lymphocytes: role of the guanylate cyclase.
Topics: Alkaloids; Aminoquinolines; Animals; Apoptosis; Burns; Carbazoles; Cell Division; Cells, Cultured; Enzyme Inhibitors; Guanylate Cyclase; Indoles; Lymphocyte Activation; Male; Necrosis; Nitric Oxide; Oxadiazoles; Protein Kinase Inhibitors; Quinoxalines; Rats; Rats, Wistar; Skin; Spleen; T-Lymphocytes | 2003 |
Effect of nitric oxide on lung surfactant secretion.
Topics: Animals; Carbazoles; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelial Cells; Guanidines; Indoles; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitrogen Oxides; Oxadiazoles; Perfusion; Phosphatidylcholines; Pulmonary Alveoli; Pulmonary Surfactants; Quinoxalines; Rats; Rats, Sprague-Dawley; Spermine | 2003 |
Nitric oxide and cGMP activate the Ras-MAP kinase pathway-stimulating protein tyrosine phosphorylation in rabbit aortic endothelial cells.
Topics: Animals; Aorta; Blotting, Western; Carbazoles; Cyclic GMP; Cytosol; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Free Radicals; Genes, Dominant; Glutathione Transferase; Indoles; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; Nitric Oxide; Nitroprusside; Oxadiazoles; Phosphorylation; Precipitin Tests; Proto-Oncogene Proteins p21(ras); Quinoxalines; Rabbits; S-Nitroso-N-Acetylpenicillamine; Signal Transduction; Transfection; Tyrosine | 2003 |
G protein-coupled endothelial receptor for atypical cannabinoid ligands modulates a Ca2+-dependent K+ current.
Topics: Animals; Arteries; Calcium; Cannabinoids; Carbazoles; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Dronabinol; Electrophysiology; Endothelium; Endothelium, Vascular; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Guanylate Cyclase; Humans; Indoles; Kinetics; Ligands; Male; Membrane Potentials; Oxadiazoles; Patch-Clamp Techniques; Peptides; Pertussis Toxin; Potassium; Potassium Channels; Quinoxalines; Rats; Rats, Sprague-Dawley; Resorcinols; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Umbilical Veins; Vasodilator Agents | 2003 |
Guanylyl cyclase inhibitors NS2028 and ODQ and protein kinase G (PKG) inhibitor KT5823 trigger apoptotic DNA fragmentation in immortalized uterine epithelial cells: anti-apoptotic effects of basal cGMP/PKG.
Topics: Animals; Apoptosis; Carbazoles; Cell Line, Transformed; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; DNA; DNA Fragmentation; Enzyme Inhibitors; Epithelial Cells; Female; Guanylate Cyclase; Indoles; Oxadiazoles; Oxazines; Quinoxalines; Signal Transduction; Uterus | 2003 |
Role of adenylate and guanylate cyclases in beta1-, beta2-, and beta3-adrenoceptor-mediated relaxation of internal anal sphincter smooth muscle.
Topics: Adenine; Adenylyl Cyclases; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Blotting, Western; Carbazoles; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; GTP-Binding Proteins; Guanylate Cyclase; Indoles; Male; Muscle Relaxation; Muscle, Smooth; Oxadiazoles; Procaterol; Pyrroles; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-2; Receptors, Adrenergic, beta-3; Suramin; Xamoterol | 2004 |
Peripheral analgesic blockade of hypernociception: activation of arginine/NO/cGMP/protein kinase G/ATP-sensitive K+ channel pathway.
Topics: Adenosine Triphosphate; Analgesics; Animals; Arginine; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dinoprostone; Indoles; Male; Nitric Oxide; Nociceptors; omega-N-Methylarginine; Oxadiazoles; Potassium Channels; Quinoxalines; Rats; Rats, Wistar; Signal Transduction | 2004 |
Nitric oxide activates glibenclamide-sensitive K+ channels in urinary bladder myocytes through a c-GMP-dependent mechanism.
Topics: Adenosine Triphosphate; Animals; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Glyburide; Guinea Pigs; Indoles; Ion Channel Gating; Male; Membrane Potentials; Molsidomine; Myocytes, Smooth Muscle; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Patch-Clamp Techniques; Potassium Channels; Quinoxalines; Signal Transduction; Urinary Bladder | 2004 |
Involvement of nitric oxide pathways in short term modulation of tyrosine hydroxylase activity by endothelins 1 and 3 in the rat anterior hypothalamus.
Topics: Animals; Carbazoles; Cyclic GMP; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Endothelin-3; Hypothalamus, Anterior; Indazoles; Indoles; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type I; Nitroprusside; Oligopeptides; Oxadiazoles; Piperidines; Quinoxalines; Rats; Suramin; Tyrosine 3-Monooxygenase | 2005 |
Effect of diabetes on the mechanisms of intrathecal antinociception of sildenafil in rats.
Topics: Analgesia; Animals; Blood Glucose; Body Weight; Carbazoles; Cyclic GMP-Dependent Protein Kinases; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Formaldehyde; Guanylate Cyclase; Indoles; Injections, Spinal; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxadiazoles; Pain; Pain Measurement; Phosphodiesterase Inhibitors; Piperazines; Potassium Channel Blockers; Purines; Quinoxalines; Rats; Rats, Wistar; Sildenafil Citrate; Streptozocin; Sulfones; Time Factors | 2005 |
The nitric oxide-cyclic GMP-protein kinase G-K+ channel pathway participates in the antiallodynic effect of spinal gabapentin.
Topics: Amines; Analgesics; Animals; Apamin; Carbazoles; Charybdotoxin; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclohexanecarboxylic Acids; Diazoxide; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Gabapentin; gamma-Aminobutyric Acid; Glyburide; Indazoles; Indoles; Injections, Spinal; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Okadaic Acid; Oxadiazoles; Pain; Pinacidil; Potassium Channel Blockers; Potassium Channels; Protein Kinase Inhibitors; Quinoxalines; Rats; Rats, Wistar; Signal Transduction; Spinal Nerves; Stereoisomerism; Time Factors; Vasodilator Agents | 2006 |
Peripheral antinociceptive effect of pertussis toxin: activation of the arginine/NO/cGMP/PKG/ ATP-sensitive K channel pathway.
Topics: Adenosine Triphosphate; Analgesia; Analgesics; Animals; Arginine; Bucladesine; Carbazoles; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dinoprostone; Enzyme Inhibitors; Ganglia, Spinal; Glyburide; Indoles; KATP Channels; Male; Neurons; Nitric Oxide; omega-N-Methylarginine; Oxadiazoles; Pain; Pain Measurement; Pertussis Toxin; Potassium Channels, Inwardly Rectifying; Quinoxalines; Rats; Rats, Wistar; Signal Transduction; Tolbutamide | 2006 |
The release of nitric oxide from S-nitrosothiols promotes angiogenesis.
Topics: Animals; Ascorbic Acid; Carbazoles; Cells, Cultured; Culture Media, Serum-Free; Cyclic GMP-Dependent Protein Kinases; Dithiothreitol; Endothelial Cells; Enzyme Inhibitors; Guanylate Cyclase; Neovascularization, Physiologic; Nitric Oxide; Nitric Oxide Synthase Type III; Nitroarginine; Ornithine; Oxadiazoles; Phosphorylation; Quinoxalines; S-Nitrosothiols; Swine | 2006 |
Peroxynitrite inhibits the expression of G(i)alpha protein and adenylyl cyclase signaling in vascular smooth muscle cells.
Topics: Adenylyl Cyclase Inhibitors; Animals; Aorta, Thoracic; Blotting, Western; Carbazoles; Cells, Cultured; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gs; Indoles; Mitogen-Activated Protein Kinases; Muscle Relaxation; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Oxadiazoles; Peroxynitrous Acid; Quinoxalines; Rats; Receptor, Angiotensin, Type 1; Receptors, Atrial Natriuretic Factor; Signal Transduction | 2008 |
Dual effect of nitric oxide on ATP-sensitive K+ channels in rat pancreatic beta cells.
Topics: Adenosine Triphosphate; Animals; Carbazoles; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Diazoxide; Dose-Response Relationship, Drug; Guanylate Cyclase; Insulin; Insulin-Secreting Cells; KATP Channels; Male; Membrane Potentials; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Patch-Clamp Techniques; Protein Kinase Inhibitors; Quinoxalines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Triazenes; Uncoupling Agents | 2008 |
Vardenafil protects isolated rat hearts at reperfusion dependent on GC and PKG.
Topics: Animals; Calcium; Carbazoles; Cell Adhesion Molecules; Cell Death; Cell Line; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Female; Guanylate Cyclase; Imidazoles; In Vitro Techniques; Microfilament Proteins; Mitochondria, Heart; Mitochondrial Membranes; Myocardial Infarction; Myocardial Reperfusion Injury; Myocytes, Cardiac; Oxadiazoles; Phosphodiesterase Inhibitors; Phosphoproteins; Piperazines; Quinoxalines; Rats; Sulfones; Triazines; Vardenafil Dihydrochloride | 2008 |
Nitric oxide attenuates the expression of natriuretic peptide receptor C and associated adenylyl cyclase signaling in aortic vascular smooth muscle cells: role of MAPK.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Aorta; Carbazoles; Cells, Cultured; Down-Regulation; Enzyme Inhibitors; Flavonoids; Free Radical Scavengers; GTP-Binding Protein alpha Subunits, Gi-Go; MAP Kinase Signaling System; Metalloporphyrins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Phosphorylation; Protein Kinase Inhibitors; Quinoxalines; Rats; Receptors, Atrial Natriuretic Factor; S-Nitroso-N-Acetylpenicillamine | 2009 |
Complex interactions of NO/cGMP/PKG systems on Ca2+ signaling in afferent arteriolar vascular smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; ADP-ribosyl Cyclase; Animals; Arterioles; Calcium; Calcium Signaling; Carbazoles; Cyclic AMP; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Activators; Enzyme Inhibitors; Male; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Peptides; Phosphodiesterase Inhibitors; Potassium Chloride; Quinoxalines; Rats; Rats, Sprague-Dawley | 2010 |
Neuroprotective mechanisms of minocycline against sphingomyelinase/ceramide toxicity: Roles of Bcl-2 and thioredoxin.
Topics: Animals; Blotting, Western; Carbazoles; Cells, Cultured; Ceramides; Cyclic GMP; Cyclic GMP-Dependent Protein Kinase Type I; Cyclic GMP-Dependent Protein Kinases; Dinitrochlorobenzene; Genes, bcl-2; Minocycline; Neurons; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Proto-Oncogene Proteins c-bcl-2; Quinoxalines; Rats; Rats, Sprague-Dawley; Signal Transduction; Sphingomyelin Phosphodiesterase; Thioredoxins | 2011 |
2,3,4',5-tetrahydroxystilbene-2-O-β-D-glucoside inhibits proliferation of vascular smooth muscle cells: involvement of NO/cGMP/PKG pathway.
Topics: Animals; Becaplermin; Carbazoles; Cell Cycle; Cell Proliferation; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Glucosides; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Polygonum; Proto-Oncogene Proteins c-sis; Quinoxalines; Rats; Rats, Sprague-Dawley; Signal Transduction; Stilbenes | 2012 |
Spermidine decreases Na⁺,K⁺-ATPase activity through NMDA receptor and protein kinase G activation in the hippocampus of rats.
Topics: Animals; Biguanides; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dizocilpine Maleate; Enzyme Activation; Hippocampus; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Sodium-Potassium-Exchanging ATPase; Spermidine | 2012 |
Essential role of nitric oxide in acute ischemic preconditioning: S-nitros(yl)ation versus sGC/cGMP/PKG signaling?
Topics: Animals; Ascorbic Acid; Carbazoles; Cells, Cultured; Cyclic GMP-Dependent Protein Kinases; Guanylate Cyclase; Ischemic Preconditioning, Myocardial; Male; Mice; Mice, Inbred C57BL; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitrosation; Organ Culture Techniques; Oxadiazoles; Quinoxalines; Reperfusion Injury; Signal Transduction | 2013 |
Nitric oxide augments single Ca(2+) channel currents via cGMP-dependent protein kinase in Kenyon cells isolated from the mushroom body of the cricket brain.
Topics: Action Potentials; Animals; Brain; Calcium Channels; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Gryllidae; Male; Mushroom Bodies; Neurons; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Quinoxalines; S-Nitrosoglutathione; Signal Transduction | 2015 |
Cyclic GMP-mediated memory enhancement in the object recognition test by inhibitors of phosphodiesterase-2 in mice.
Topics: Animals; Carbazoles; Cell Adhesion Molecules; Cyclic AMP Response Element-Binding Protein; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 2; Dose-Response Relationship, Drug; Guanylate Cyclase; Imidazoles; Male; Memory; Mice, Inbred ICR; Microfilament Proteins; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxadiazoles; Phosphodiesterase Inhibitors; Phosphoproteins; Protein Kinase Inhibitors; Quinoxalines; Recognition, Psychology; Triazines | 2016 |
Modulation of growth cone filopodial length by carbon monoxide.
Topics: Action Potentials; Animals; Calcium; Carbazoles; Carbon Monoxide; Enzyme Inhibitors; Ganglia, Invertebrate; Growth Cones; Heme Oxygenase-1; Neurons; Nitric Oxide; Organometallic Compounds; Oxadiazoles; Oxazines; Patch-Clamp Techniques; Pseudopodia; Quinoxalines; Signal Transduction; Snails; Time Factors | 2017 |
Effects of Nitric Oxide on Voltage-Gated K⁺ Currents in Human Cardiac Fibroblasts through the Protein Kinase G and Protein Kinase A Pathways but Not through S-Nitrosylation.
Topics: Action Potentials; Adenine; Carbazoles; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Humans; Myofibroblasts; Nitric Oxide; Oxadiazoles; Potassium Channels, Voltage-Gated; Pyrroles; Quinoxalines; S-Nitroso-N-Acetylpenicillamine | 2018 |