Page last updated: 2024-09-02

kt 5823 and 1-methyl-3-isobutylxanthine

kt 5823 has been researched along with 1-methyl-3-isobutylxanthine in 16 studies

Compound Research Comparison

Studies
(kt 5823)
Trials
(kt 5823)
Recent Studies (post-2010)
(kt 5823)
Studies
(1-methyl-3-isobutylxanthine)
Trials
(1-methyl-3-isobutylxanthine)
Recent Studies (post-2010) (1-methyl-3-isobutylxanthine)
3170595,1485279

Protein Interaction Comparison

ProteinTaxonomykt 5823 (IC50)1-methyl-3-isobutylxanthine (IC50)
Chain A, High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7AHomo sapiens (human)8.1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4DHomo sapiens (human)31
Chain A, Phosphodiesterase 9AHomo sapiens (human)500
Chain A, Class I phosphodiesterase PDEB1Leishmania major580
Chain A, High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8AHomo sapiens (human)698
Chain A, cGMP-dependent 3',5'-cyclic phosphodiesteraseHomo sapiens (human)40
Chain A, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9AHomo sapiens (human)117.2
Chain A, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9AHomo sapiens (human)117.2
Phosphodiesterase Bos taurus (cattle)9.9
cGMP-dependent 3',5'-cyclic phosphodiesteraseHomo sapiens (human)4
cGMP-specific 3',5'-cyclic phosphodiesteraseHomo sapiens (human)3.1667
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A Bos taurus (cattle)9.9
Adenosine receptor A1Rattus norvegicus (Norway rat)7
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1AHomo sapiens (human)3.4
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1BBos taurus (cattle)9.9
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1BHomo sapiens (human)3.4
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1BRattus norvegicus (Norway rat)0.1
cGMP-inhibited 3',5'-cyclic phosphodiesterase BHomo sapiens (human)0.242
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1CHomo sapiens (human)3.4
cGMP-inhibited 3',5'-cyclic phosphodiesterase AHomo sapiens (human)7
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1CRattus norvegicus (Norway rat)0.1
Phosphodiesterase Rattus norvegicus (Norway rat)0.1

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (31.25)18.2507
2000's8 (50.00)29.6817
2010's2 (12.50)24.3611
2020's1 (6.25)2.80

Authors

AuthorsStudies
Dollinger, SJ; Wahler, GM1
Garcia, NH; Garvin, JL1
Emaduddin, M; Liu, GJ; Munekata, E; Takeuchi, H1
Joyner, RW; Kumar, R; Namiki, T1
Bełtowski, J; Górny, D; Marciniak, A1
Wang, WH1
Joyner, RW; Kumar, R; Wagner, MB; Wang, Y1
Ferreyra, GA; Golombek, DA1
Bruckdorfer, KR; Friebe, A; Koesling, D; Naseem, KM; Sabetkar, M; Tullett, JM1
Ahern, GP; Jackson, MB; Klyachko, VA1
Bełtowski, J; Górny, D; Marciniak, A; Wójcicka, G1
Delbecque, JP; Gautron, F; Manière, G; Vanhems, E1
Burrell, HE; Durham, B; Fraser, WD; Gallagher, JA; McCreavy, DT; Mehat, S; Sharpe, GR; Simpson, AW1
Arendshorst, WJ; Fellner, SK1
Han, J; Lee, S; Xu, Z1
Güven, C; Parlar, A1

Other Studies

16 other study(ies) available for kt 5823 and 1-methyl-3-isobutylxanthine

ArticleYear
Nitric oxide donor SIN-1 inhibits mammalian cardiac calcium current through cGMP-dependent protein kinase.
    The American journal of physiology, 1995, Volume: 268, Issue:1 Pt 1

    Topics: 1-Methyl-3-isobutylxanthine; Alkaloids; Aminoquinolines; Animals; Calcium; Carbazoles; Cyclic GMP-Dependent Protein Kinases; Electric Conductivity; Guanylate Cyclase; Guinea Pigs; Heart; Indoles; Isoproterenol; Molsidomine; Myocardium; Nitric Oxide; Protein Kinase Inhibitors

1995
ANF and angiotensin II interact via kinases in the proximal straight tubule.
    The American journal of physiology, 1995, Volume: 268, Issue:4 Pt 2

    Topics: 1-Methyl-3-isobutylxanthine; Absorption; Alkaloids; Angiotensin II; Animals; Atrial Natriuretic Factor; Carbazoles; Cyclic AMP; Drug Interactions; Indoles; Kidney Tubules, Proximal; Male; Phosphotransferases; Rats; Rats, Sprague-Dawley; Staurosporine

1995
Multiple intracellular signal transduction pathways mediating inward current produced by the neuropeptide, achatin-I.
    European journal of pharmacology, 1996, Apr-29, Volume: 302, Issue:1-3

    Topics: 1-Methyl-3-isobutylxanthine; Alkaloids; Analysis of Variance; Animals; Carbazoles; Dose-Response Relationship, Drug; Indoles; Isoquinolines; Naphthalenes; Neurons; Neuropeptides; Neurotransmitter Agents; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Protein Kinase C; Protein Kinase Inhibitors; Signal Transduction; Snails; Sulfonamides; Vasodilator Agents

1996
Effects of cGMP on L-type calcium current of adult and newborn rabbit ventricular cells.
    Cardiovascular research, 1997, Volume: 33, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Alkaloids; Aminoquinolines; Animals; Animals, Newborn; Calcium; Calcium Channels; Carbazoles; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Female; Glutathione; Guanylate Cyclase; Indoles; Male; Methylene Blue; Myocardium; Nitroso Compounds; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Protein Kinase Inhibitors; Rabbits; S-Nitrosoglutathione; Thionucleotides; Time Factors

1997
The mechanism of Na+, K+-ATPase inhibition by atrial natriuretic factor in rat renal medulla.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 1998, Volume: 49, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Alkaloids; Animals; Atrial Natriuretic Factor; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Indoles; Kidney Medulla; Male; Papaverine; Phosphodiesterase Inhibitors; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase

1998
The cGMP-dependent protein kinase stimulates the basolateral 18-pS K channel of the rat CCD.
    American journal of physiology. Cell physiology, 2000, Volume: 278, Issue:6

    Topics: 1-Methyl-3-isobutylxanthine; Alkaloids; Animals; Carbazoles; Cell Membrane; Cyclic AMP; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Indoles; Kidney Cortex; Kidney Tubules, Collecting; Membrane Potentials; Patch-Clamp Techniques; Potassium Channels; Rats; Rats, Sprague-Dawley

2000
cGMP-dependent protein kinase mediates stimulation of L-type calcium current by cGMP in rabbit atrial cells.
    Cardiovascular research, 2000, Volume: 48, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Alkaloids; Animals; Blotting, Western; Calcium Channels, L-Type; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Heart Atria; Indoles; Isoproterenol; Myocardium; Nitric Oxide Donors; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Rabbits; Stimulation, Chemical; Time Factors

2000
Rhythmicity of the cGMP-related signal transduction pathway in the mammalian circadian system.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2001, Volume: 280, Issue:5

    Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Alkaloids; Animals; Brain; Carbazoles; Circadian Rhythm; Cricetinae; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Darkness; Enzyme Inhibitors; Indoles; Injections, Intraventricular; Isoenzymes; Light; Male; Mammals; Mesocricetus; Motor Activity; Oxadiazoles; Photoperiod; Quinoxalines; Signal Transduction; Suprachiasmatic Nucleus

2001
Synergism between nitric oxide and hydrogen peroxide in the inhibition of platelet function: the roles of soluble guanylyl cyclase and vasodilator-stimulated phosphoprotein.
    Nitric oxide : biology and chemistry, 2001, Volume: 5, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Alkaloids; Blood Platelets; Blood Proteins; Carbazoles; Cell Adhesion Molecules; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cytosol; Drug Synergism; Enzyme Inhibitors; Guanylate Cyclase; Humans; Hydrazines; Hydrogen Peroxide; In Vitro Techniques; Indazoles; Indoles; Kinetics; Microfilament Proteins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Phosphoproteins; Phosphoserine; Platelet Aggregation; Platelet Aggregation Inhibitors; Subcellular Fractions; Thrombin

2001
cGMP-mediated facilitation in nerve terminals by enhancement of the spike afterhyperpolarization.
    Neuron, 2001, Sep-27, Volume: 31, Issue:6

    Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Alkaloids; Animals; Calcium; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Guanylate Cyclase; Indoles; Ion Channel Gating; Ion Transport; Ionomycin; Isoquinolines; Large-Conductance Calcium-Activated Potassium Channels; Nerve Tissue Proteins; Neuronal Plasticity; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitroprusside; Oxadiazoles; Patch-Clamp Techniques; Photolysis; Pituitary Gland, Posterior; Potassium; Potassium Channels; Potassium Channels, Calcium-Activated; Quinoxalines; Signal Transduction; Sodium; Sodium Channels; Sulfonamides; Thionucleotides

2001
The opposite effects of cyclic AMP-protein kinase a signal transduction pathway on renal cortical and medullary Na+,K+-ATPase activity.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2002, Volume: 53, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Alkaloids; Animals; Arachidonic Acid; Bucladesine; Carbazoles; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cytochrome P-450 Enzyme System; Enzyme Activation; Enzyme Inhibitors; Hydroxyeicosatetraenoic Acids; Indoles; Kidney Cortex; Kidney Medulla; Male; Okadaic Acid; Phosphodiesterase Inhibitors; Pyrroles; Rats; Rats, Wistar; Signal Transduction; Sodium-Potassium-Exchanging ATPase

2002
Inhibition of ovarian steroidogenesis by cyclic GMP in a fly.
    The Journal of endocrinology, 2003, Volume: 177, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Adenine; Alkaloids; Animals; Brain; Calcium Channels; Carbazoles; Colforsin; Cyclic AMP; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Diptera; Ecdysteroids; Female; Indoles; Organ Culture Techniques; Ovary; Phosphodiesterase Inhibitors; Quinazolines; Signal Transduction; Stimulation, Chemical

2003
Potentiation of ATP- and bradykinin-induced [Ca2+]c responses by PTHrP peptides in the HaCaT cell line.
    The Journal of investigative dermatology, 2008, Volume: 128, Issue:5

    Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Bradykinin; Calcium; Carbazoles; Cell Division; Cell Line; Colforsin; Cyclic AMP; Cyclic GMP; Drug Synergism; Humans; Indoles; Keratinocytes; Parathyroid Hormone-Related Protein; Peptide Fragments; Phosphodiesterase Inhibitors; Protein Kinase Inhibitors; Signal Transduction

2008
Complex interactions of NO/cGMP/PKG systems on Ca2+ signaling in afferent arteriolar vascular smooth muscle.
    American journal of physiology. Heart and circulatory physiology, 2010, Volume: 298, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; ADP-ribosyl Cyclase; Animals; Arterioles; Calcium; Calcium Signaling; Carbazoles; Cyclic AMP; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Activators; Enzyme Inhibitors; Male; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Peptides; Phosphodiesterase Inhibitors; Potassium Chloride; Quinoxalines; Rats; Rats, Sprague-Dawley

2010
Dual role of cyclic GMP in cardiac cell survival.
    The international journal of biochemistry & cell biology, 2013, Volume: 45, Issue:8

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Carbazoles; Cell Adhesion Molecules; Cell Line; Cell Survival; Cyclic GMP; Fluorescence; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Insulin; Marine Toxins; Microfilament Proteins; Myocytes, Cardiac; Oxazoles; Phosphoproteins; Phosphorylation; Phosphoserine; Proto-Oncogene Proteins c-akt; Rats

2013
Glabridin Relaxes Vascular Smooth Muscles by Activating BK
    Current medical science, 2021, Volume: 41, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Endothelium, Vascular; Humans; Ion Channel Gating; Isoflavones; Large-Conductance Calcium-Activated Potassium Channel alpha Subunits; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Peptides; Phenols; Phenylephrine; Phosphodiesterase Inhibitors; Saphenous Vein; Vasodilation

2021