kt-5720 and 1-amino-1-3-dicarboxycyclopentane

kt-5720 has been researched along with 1-amino-1-3-dicarboxycyclopentane* in 1 studies

Other Studies

1 other study(ies) available for kt-5720 and 1-amino-1-3-dicarboxycyclopentane

Article	Year
Gating of BDNF-induced synaptic potentiation by cAMP. Science (New York, N.Y.), 1999, Jun-18, Volume: 284, Issue:5422 Neurotrophins have been implicated in activity-dependent synaptic plasticity, but the underlying intracellular mechanisms remain largely unknown. Synaptic potentiation induced by brain-derived neurotrophic factor (BDNF), but not neurotrophin 3, was prevented by blockers of adenosine 3',5'-monophosphate (cAMP) signaling. Activators of cAMP signaling alone were ineffective in modifying synaptic efficacy but greatly enhanced the potentiation effect of BDNF. Blocking cAMP signaling abolished the facilitation of BDNF-induced potentiation by presynaptic activity. Thus synaptic actions of BDNF are gated by cAMP. Activity and other coincident signals that modulate cAMP concentrations may specify the action of secreted neurotrophins on developing nerve terminals. Topics: Animals; Brain-Derived Neurotrophic Factor; Carbazoles; Cells, Cultured; Cyclic AMP; Cycloleucine; Excitatory Postsynaptic Potentials; Indoles; Nerve Growth Factors; Neuronal Plasticity; Neurons; Neurotrophin 3; Okadaic Acid; Patch-Clamp Techniques; Pyrroles; Signal Transduction; Synapses; Synaptic Transmission; Thionucleotides; Xenopus	1999

Article

Year

Gating of BDNF-induced synaptic potentiation by cAMP.

Science (New York, N.Y.), 1999, Jun-18, Volume: 284, Issue:5422

Neurotrophins have been implicated in activity-dependent synaptic plasticity, but the underlying intracellular mechanisms remain largely unknown. Synaptic potentiation induced by brain-derived neurotrophic factor (BDNF), but not neurotrophin 3, was prevented by blockers of adenosine 3',5'-monophosphate (cAMP) signaling. Activators of cAMP signaling alone were ineffective in modifying synaptic efficacy but greatly enhanced the potentiation effect of BDNF. Blocking cAMP signaling abolished the facilitation of BDNF-induced potentiation by presynaptic activity. Thus synaptic actions of BDNF are gated by cAMP. Activity and other coincident signals that modulate cAMP concentrations may specify the action of secreted neurotrophins on developing nerve terminals.

Topics: Animals; Brain-Derived Neurotrophic Factor; Carbazoles; Cells, Cultured; Cyclic AMP; Cycloleucine; Excitatory Postsynaptic Potentials; Indoles; Nerve Growth Factors; Neuronal Plasticity; Neurons; Neurotrophin 3; Okadaic Acid; Patch-Clamp Techniques; Pyrroles; Signal Transduction; Synapses; Synaptic Transmission; Thionucleotides; Xenopus

1999