krn-7000 and safingol

krn-7000 has been researched along with safingol* in 1 studies

Other Studies

1 other study(ies) available for krn-7000 and safingol

ArticleYear
Synthesis and evaluation of sphinganine analogues of KRN7000 and OCH.
    The Journal of organic chemistry, 2005, Dec-09, Volume: 70, Issue:25

    [structures: see text] The phytosphingosine-containing alpha-galactosylceramides (alpha-GalCers), KRN7000 and OCH, have been shown to activate NKT cells via interaction with CD1d, a member of the CD1 family of antigen presenting proteins. Evidence from KRN7000 stimulation of NKT cells suggests that alpha-GalCers may have applications in the treatment or prevention of a range of viral, bacterial, and autoimmune conditions. Moreover, OCH, a truncated analogue of KRN7000, appears to induce a T(H)2 bias, which could have implications for the treatment of autoimmune and inflammatory conditions. We have prepared the direct sphinganine-containing analogues of KRN7000 and OCH, 1 and 2, and found them to be comparable in activity to the parent compounds in inducing the release of IL-2, IL-4, and IFNgamma. In addition, compound 2 leads to a cytokine bias similar to that seen with OCH. This is significant because sphinganines are more easily accessed than phytosphingosines, which should facilitate SAR studies.

    Topics: Animals; Antigen Presentation; Cells, Cultured; Galactosylceramides; Glycolipids; Interferon-gamma; Interleukin-4; Mice; Mice, Inbred C57BL; Sphingosine; Spleen; Structure-Activity Relationship; T-Lymphocytes

2005