krn-7000 and galactocerebroside

krn-7000 has been researched along with galactocerebroside* in 1 studies

Other Studies

1 other study(ies) available for krn-7000 and galactocerebroside

ArticleYear
Hypothesized role of galactocerebroside and NKT cells in the etiology of multiple sclerosis.
    Medical hypotheses, 2008, Volume: 70, Issue:4

    According to the molecular mimicry theory, multiple sclerosis (MS) develops when the immune system mistakenly attacks a component of the myelin sheath that is structurally similar to a foreign epitope. The glycolipid galactocerebroside (GalC) is a major component of myelin. As lipids comprise between 70% and 85% of myelin, glycolipids should be investigated as candidate autoantigens in MS. GalC displays broad structural similarities to the Borrelia burgdorferi glycolipid antigen BbGL-2 and to the Sphingomonas antigen GalAGSL. In principle, therefore, these bacteria may induce an autoimmune attack on the myelin sheath. GalC is also structurally similar to natural killer T (NKT) cell ligand alpha-galactosylceramide (alpha-GalCer). Further studies must be performed to clarify the role of GalC in the activation of NKT cells and the development of MS.

    Topics: Animals; Autoimmunity; Borrelia burgdorferi; Galactosylceramides; Glycolipids; Humans; Killer Cells, Natural; Ligands; Models, Biological; Models, Chemical; Models, Theoretical; Multiple Sclerosis; Myelin Sheath; Sphingomonas

2008