krn-7000 has been researched along with galactocerebroside* in 1 studies
1 other study(ies) available for krn-7000 and galactocerebroside
Article | Year |
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Hypothesized role of galactocerebroside and NKT cells in the etiology of multiple sclerosis.
According to the molecular mimicry theory, multiple sclerosis (MS) develops when the immune system mistakenly attacks a component of the myelin sheath that is structurally similar to a foreign epitope. The glycolipid galactocerebroside (GalC) is a major component of myelin. As lipids comprise between 70% and 85% of myelin, glycolipids should be investigated as candidate autoantigens in MS. GalC displays broad structural similarities to the Borrelia burgdorferi glycolipid antigen BbGL-2 and to the Sphingomonas antigen GalAGSL. In principle, therefore, these bacteria may induce an autoimmune attack on the myelin sheath. GalC is also structurally similar to natural killer T (NKT) cell ligand alpha-galactosylceramide (alpha-GalCer). Further studies must be performed to clarify the role of GalC in the activation of NKT cells and the development of MS. Topics: Animals; Autoimmunity; Borrelia burgdorferi; Galactosylceramides; Glycolipids; Humans; Killer Cells, Natural; Ligands; Models, Biological; Models, Chemical; Models, Theoretical; Multiple Sclerosis; Myelin Sheath; Sphingomonas | 2008 |