krn-7000 has been researched along with azobenzene* in 1 studies
1 other study(ies) available for krn-7000 and azobenzene
Article | Year |
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Photo effect on the CD1d-binding ability of azobenzene-attached analogues of α-GalCer.
α-Galactosylceramide (α-GalCer) is recognized by the CD1d proteins on antigen-presenting cells at the ceramide moiety and the galactose moiety is presented to iNKT cells, which stimulates the immune responses. However, the immune suppression by repeated injections of α-GalCer has discouraged its development as an anti-cancer agent. To overcome the shortcoming by spatiotemporal restriction of its exposure, we synthesized the photochromic azobenzene-incorporated analogues and tested the photo-immunoregulation effect in its binding to CD1d. FACS analyses indicated that some of these analogues enhanced the affinity to CD1d on photo-irradiation by about 20%. A docking simulation suggests that the photochromic molecule should be bulkier for a clearer discrimination between on and off states. Topics: Animals; Antigens, CD1d; Azo Compounds; Galactosylceramides; Humans; Mice; Molecular Docking Simulation; Natural Killer T-Cells; Protein Binding | 2020 |