kp-1461 has been researched along with 5-6-dihydro-5-azacytidine* in 1 studies
1 other study(ies) available for kp-1461 and 5-6-dihydro-5-azacytidine
Article | Year |
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KP-1212/1461, a nucleoside designed for the treatment of HIV by viral mutagenesis.
We report the activities of a novel nucleoside analog against HIV. This nucleoside (KP-1212) is not a chain terminator but exerts its antiviral effects via mutagenesis of the viral genome. Serial passaging of HIV in the presence of KP-1212 causes an increase in the mutation rate of the virus leading to viral ablation. HIV strains resistant to KP-1212 have not yet been isolated. Quite to the contrary, virus treated with KP-1212 exhibited an increased sensitivity not only to KP-1212 but also to another nucleoside reverse transcriptase inhibitor (NRTI), zidovudine. HIV strains resistant to other NRTIs (e.g. zidovudine, lamivudine, stavudine, abacavir, etc.) exhibited no cross-resistance towards KP-1212. Multiple assays confirmed that KP-1212 has a favorable (low) genotoxicity profile when compared to some approved antiviral nucleosides. In addition, KP-1212 is not toxic to mitochondria nor does it exhibit any inhibitory effects on mitochondrial DNA synthesis. Topics: Animals; Anti-HIV Agents; Azacitidine; Cell Line; Cricetinae; HIV Infections; HIV-1; Humans; Microbial Sensitivity Tests; Mutation; Nucleosides; Reverse Transcriptase Inhibitors; Zidovudine | 2005 |