kn-62 and alpha-methyl-4-carboxyphenylglycine

kn-62 has been researched along with alpha-methyl-4-carboxyphenylglycine* in 1 studies

Other Studies

1 other study(ies) available for kn-62 and alpha-methyl-4-carboxyphenylglycine

Article	Year
A CaMKII inhibitor, KN-62, facilitates DHPG-induced LTD in the CA1 region of the hippocampus. Neuropharmacology, 1999, Volume: 38, Issue:4 We have shown previously that activation of mGlu receptors using a group I specific mGlu receptor agonist, (R,S)-3,5-dihydroxyphenylglycine (DHPG), can induce long-term depression (LTD) in the CA1 region of the hippocampus (Palmer et al., 1997). We now report that DHPG-induced LTD is facilitated by treatment with KN-62, an inhibitor of certain Ca2+/calmodulin-dependent protein kinases (CaMKs), including CaMKII. Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Benzoates; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Depression, Chemical; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Female; Glycine; Hippocampus; In Vitro Techniques; Methoxyhydroxyphenylglycol; Neuronal Plasticity; Rats; Rats, Wistar; Signal Transduction; Synaptic Transmission	1999

Article

Year

A CaMKII inhibitor, KN-62, facilitates DHPG-induced LTD in the CA1 region of the hippocampus.

Neuropharmacology, 1999, Volume: 38, Issue:4

We have shown previously that activation of mGlu receptors using a group I specific mGlu receptor agonist, (R,S)-3,5-dihydroxyphenylglycine (DHPG), can induce long-term depression (LTD) in the CA1 region of the hippocampus (Palmer et al., 1997). We now report that DHPG-induced LTD is facilitated by treatment with KN-62, an inhibitor of certain Ca2+/calmodulin-dependent protein kinases (CaMKs), including CaMKII.

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Benzoates; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Depression, Chemical; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Female; Glycine; Hippocampus; In Vitro Techniques; Methoxyhydroxyphenylglycol; Neuronal Plasticity; Rats; Rats, Wistar; Signal Transduction; Synaptic Transmission

1999