kn 04 has been researched along with 1-(5-isoquinolinesulfonyl)-2-methylpiperazine in 12 studies
| Studies (kn 04) | Trials (kn 04) | Recent Studies (post-2010) (kn 04) | Studies (1-(5-isoquinolinesulfonyl)-2-methylpiperazine) | Trials (1-(5-isoquinolinesulfonyl)-2-methylpiperazine) | Recent Studies (post-2010) (1-(5-isoquinolinesulfonyl)-2-methylpiperazine) |
|---|---|---|---|---|---|
| 12 | 0 | 0 | 3,412 | 41 | 631 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (58.33) | 18.2507 |
| 2000's | 4 (33.33) | 29.6817 |
| 2010's | 1 (8.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hashiba, Y; Hidaka, H; Ishikawa, N | 1 |
| Fukunaga, K; Izumi, F; Kuroiwa, A; Minami, K; Miyamoto, E; Nakashima, Y; Tsutsui, M; Yanagihara, N | 1 |
| Gargett, CE; Wiley, JS | 1 |
| Inagaki, N; Iwahashi, K; Kitai, H; Kuji, N; Nakatogawa, N; Suzuki, S; Yoshimura, Y | 1 |
| Dubyak, GR; Humphreys, BD; Rice, J; Surprenant, A; Virginio, C | 1 |
| Haug, FM; Laake, JH; Ottersen, OP; Rundén, E; Seglen, PO; Shamloo, M; Wieloch, T | 1 |
| Brozinick, JT; Cartee, G; Cushman, SW; Dean, D; Reynolds, TH | 1 |
| Chessell, IP; Humphrey, PP; Kaur, R; Michel, AD | 1 |
| Carlier, E; Couraud, F; Dargent, B; De Waard, M | 1 |
| Kimura, J; Matsuoka, I; Watano, T | 1 |
| Duncan, M; Elssner, A; Gavrilin, M; Wewers, MD | 1 |
| Hou, X; Wang, X; Yang, B; Yu, G; Zhang, L; Zhou, J | 1 |
12 other study(ies) available for kn 04 and 1-(5-isoquinolinesulfonyl)-2-methylpiperazine
| Article | Year |
|---|---|
Effect of a new Ca2(+)-calmodulin-dependent protein kinase II inhibitor on GABA release in cerebrospinal fluid of the rat.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blood Pressure; Calmodulin; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Heart Rate; Isoquinolines; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Rats; Sulfonamides; Vasodilator Agents | 1990 |
Ca(2+)/calmodulin-dependent protein kinase II inhibitor KN-62 inhibits adrenal medullary chromaffin cell functions independent of its action on the kinase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adolescent; Adrenal Medulla; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Catecholamines; Cattle; Chromaffin System; Enzyme Inhibitors; Humans; Ion Channels; Isoquinolines; Nicotinic Agonists; Piperazines; Sodium; Tyrosine 3-Monooxygenase | 1996 |
The isoquinoline derivative KN-62 a potent antagonist of the P2Z-receptor of human lymphocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Calcium; Cytosol; Enzyme Inhibitors; Humans; Kinetics; Lymphocytes; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2X7 | 1997 |
Effect of KN-62, a selective inhibitor of calmodulin-dependent kinase II, on mouse oocyte activation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Female; Fertilization in Vitro; Fluorescent Dyes; Ionophores; Male; Mice; Mice, Inbred ICR; Oocytes; Protein Kinase Inhibitors | 1997 |
Isoquinolines as antagonists of the P2X7 nucleotide receptor: high selectivity for the human versus rat receptor homologues.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Cells, Cultured; Chimera; Enzyme Inhibitors; Ethidium; Fluorescent Dyes; Humans; Ion Transport; Isoquinolines; Leukocytes; Purinergic P2 Receptor Antagonists; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2X7 | 1998 |
Regional selective neuronal degeneration after protein phosphatase inhibition in hippocampal slice cultures: evidence for a MAP kinase-dependent mechanism.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antioxidants; Apoptosis; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Enzyme Inhibitors; Flavanones; Flavonoids; Genistein; Hippocampus; Indole Alkaloids; Male; Microscopy, Electron; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nerve Degeneration; Neurons; Okadaic Acid; Organ Culture Techniques; Phosphoric Monoester Hydrolases; Propidium; Protein Kinase Inhibitors; Protein Kinases; Rats; Rats, Wistar; Staurosporine; Sulfonamides | 1998 |
1-[N, O-bis-(5-isoquinolinesulphonyl)-N-methyl-L-tyrosyl]-4- phenylpiperazine (KN-62), an inhibitor of calcium-dependent camodulin protein kinase II, inhibits both insulin- and hypoxia-stimulated glucose transport in skeletal muscle.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Biological Transport; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cell Hypoxia; Cell Membrane; Deoxyglucose; Glucose; Glucose Transporter Type 4; Glycogen; In Vitro Techniques; Insulin; Insulin Antagonists; Male; Monosaccharide Transport Proteins; Muscle Proteins; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Signal Transduction | 1999 |
Antagonist effects on human P2X(7) receptor-mediated cellular accumulation of YO-PRO-1.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Antibodies, Blocking; Benzoxazoles; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Enzyme Inhibitors; Fluorescent Dyes; Humans; Imidazoles; In Vitro Techniques; Purinergic P2 Receptor Antagonists; Pyridoxal Phosphate; Quinolinium Compounds; Receptors, Purinergic P2X7; Stimulation, Chemical | 2000 |
Na(+) channel regulation by calmodulin kinase II in rat cerebellar granule cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Binding, Competitive; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cerebellum; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ion Transport; Patch-Clamp Techniques; Peptide Fragments; Rats; Sodium; Sodium Channels | 2000 |
Characteristics of ATP-induced current through P2X7 receptor in NG108-15 cells: unique antagonist sensitivity and lack of pore formation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Benzoxazoles; Cations; Cell Membrane Permeability; Fluorescent Dyes; Mice; Patch-Clamp Techniques; Purinergic P2 Receptor Antagonists; Pyridoxal Phosphate; Quinolinium Compounds; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2X7; Suramin; Triazines; Tumor Cells, Cultured | 2002 |
A novel P2X7 receptor activator, the human cathelicidin-derived peptide LL37, induces IL-1 beta processing and release.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Antimicrobial Cationic Peptides; Apyrase; Binding Sites; Caspase 1; Cathelicidins; Cell Membrane Permeability; Cells, Cultured; Enzyme Activation; Humans; Interleukin-1; Lipopolysaccharides; Monocytes; Protein Processing, Post-Translational; Purinergic P2 Receptor Antagonists; Receptors, Formyl Peptide; Receptors, Lipoxin; Receptors, Purinergic P2; Receptors, Purinergic P2X7 | 2004 |
Rebound bursts in GABAergic neurons of the thalamic reticular nucleus in postnatal mice.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4-Aminopyridine; Action Potentials; Animals; Animals, Newborn; Bicuculline; Calcium-Calmodulin-Dependent Protein Kinase Type 2; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Mice; Mice, Inbred ICR; Neural Inhibition; Neurons; Organ Culture Techniques; Potassium Channel Blockers; Protein Kinase Inhibitors; Receptors, GABA-A; Thalamic Nuclei | 2010 |