kinetin has been researched along with olomoucine in 171 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 59 (34.50) | 18.2507 |
| 2000's | 99 (57.89) | 29.6817 |
| 2010's | 12 (7.02) | 24.3611 |
| 2020's | 1 (0.58) | 2.80 |
| Authors | Studies |
|---|---|
| Brandsen, J; Jones, HD; Kim, SH; Meijer, L; Morgan, DO; Schulze-Gahmen, U; Vesely, J | 1 |
| Bergounioux, C; Glab, N; Labidi, B; Meijer, L; Qin, LX; Trehin, C | 1 |
| Abraham, RT; Acquarone, M; Andersen, A; Asensi, A; Bellé, R; Berger, F; Bergounioux, C; Brunn, G; Buquet-Fagot, C; Fagot, D | 1 |
| Farinelli, SE; Greene, LA; Park, DS | 1 |
| Geilen, CC; Orfanos, CE; Paul, C; Wieder, T; Wieprecht, M | 1 |
| Patzlaff, JS; Paulson, JR; Vallis, AJ | 1 |
| Franklin, RM; Graeser, R; Kappes, B; Wernli, B | 1 |
| Boarder, MR; Brown, C; Goodwin, A; Patel, V; Wilkie, N | 1 |
| Geller, HM; Greene, LA; Morris, EJ; Park, DS | 1 |
| Angello, JC; Margolis, RL; Palmer, DK | 1 |
| De Azevedo, WF; Havlicek, L; Kim, SH; Leclerc, S; Meijer, L; Strnad, M | 1 |
| Blow, JJ; Borgne, A; Chong, JP; Delcros, JG; Inagaki, M; Inagaki, N; Meijer, L; Moulinoux, JP; Mulner, O | 1 |
| Hanus, J; Havlícek, L; Leclerc, S; Meijer, L; Shaw, G; Strnad, M; Veselý, J | 1 |
| Choi, Y; Greengard, P; Kwon, YG; Lee, SY; Nairn, AC | 1 |
| Brophy, G; Cook, N; Davies, R; Graves, R; O'Beirne, G | 1 |
| Groden, J; Kordich, JJ; Lowy, AM; Trzepacz, C | 1 |
| Avila, J; Diaz-Nido, J; Moreno, FJ; Muñoz-Montaño, JR | 1 |
| Hellmich, MR; Iseki, H; Ko, TC; Seapan, A; Townsend, CM; Xue, XY | 1 |
| Kuijpers, HJ; Ramaekers, FC; Reutelingsperger, CP; Schutte, B; van Engeland, M | 1 |
| Buquet-Fagot, C; Lallemand, F; Mester, J; Montagne, MN | 1 |
| Lin, Q; Resnick, RJ; Shalloway, D; Taylor, SJ | 1 |
| Cassimeris, L; Howell, B; Odde, DJ | 1 |
| Henfling, ME; Meijer, L; Nieland, L; Ramaekers, FC; Schutte, B; van Engeland, M | 1 |
| Krucher, NA; Meijer, L; Roberts, MH | 1 |
| Eckberg, WR | 1 |
| Hajdúch, M; Hanus, J; Hlobílková, A; Kolár, Z; Mihál, V; Nosková, V; Novotný, R; Strnad, M | 1 |
| Geller, HM; Greene, LA; Morris, EJ; Park, DS; Shelanski, ML; Stefanis, L; Troy, CM | 1 |
| Cruz, M; Eneroth, P; Idoyaga Vargas, V; Sidén, A; Yakisich, JS | 1 |
| Butler, R; Katula, KS; Khan, AS; Nuckolls, FJ | 1 |
| Anneser, JM; Borasio, GD; Horstmann, S; Kahle, PJ; Maas, JW; Shooter, EM | 1 |
| Meijer, L | 1 |
| Brandsen, J; de Azevedo Júnior, WF; Kim, SH; Schulze-Gahmen, U | 1 |
| Anderson, JS; Grant, KM; Hassan, P; Mottram, JC | 1 |
| Phillips, J; Schaffer, PA; Schang, LM | 1 |
| Barakat, A; Genevière, AM; Lozano, JC; Marques, F; Moreau, JL; Peaucellier, G; Picard, A; Schatt, P | 1 |
| Bloom, GS; Brady, ST; Ratner, N | 1 |
| Abdel-Meguid, S; Adams, JL; Boehm, JC; Canagarajah, BJ; Cobb, MH; Goldsmith, EJ; Kassisà, S; Wang, Z; Young, PR | 1 |
| Cheng, TJ; Lai, YK | 1 |
| Alessi, F; Meijer, L; Prosperi, E; Quarta, S; Riva, F; Rossi, L; Savio, M; Scovassi, AI; Stivala, LA | 1 |
| Hung, MC; Jing, T; Liu, B; McDonnell, TJ; Tan, M; Yao, J; Yu, D | 1 |
| Bisagni, E; Leclerc, S; Legraverend, M; Ludwig, O; Meijer, L | 1 |
| Hake, L; Minshall, N; Richter, J; Standart, N; Walker, J | 1 |
| Eskin, A; Sankrithi, N | 1 |
| Bittner, MA; Fletcher, AI; Giovannucci, DR; Shuang, R; Stuenkel, EL; Zhang, L | 1 |
| Capraro, HG; Furet, P; Imbach, P; Mett, H; Meyer, T; Zimmermann, J | 1 |
| Bian, H; Chellappan, SP; Nath, N; Reed, EF | 1 |
| Gowen, M; Kumar, S; Lee, JC; Zhang, W | 1 |
| Bossenmeyer-Pourié, C; Chihab, R; Daval, JL; Schroeder, H | 1 |
| Frimpong, K; Goodwin, CD; Mau, JK; Reddy, TR; Rose, DW; Suhasini, M; Tang, H; Wong-Staal, F; Xu, W | 1 |
| Dimitriadis, KA; Geromichalos, GD; Kortsaris, AH; Kouretas, D; Papazisis, KT | 1 |
| Liu, H; Takahashi, H; Tamura, K | 1 |
| Martin, WH; Peterson, MF; Spencer, RW; Tate, BF | 1 |
| Bisagni, E; Favaudon, V; Giocanti, N; Leclerc, S; Legraverend, M; Ludwig, O; Meijer, L; Sadri, R | 1 |
| Elbaum, D; Lydon, NB; Toledo, LM | 1 |
| Détivaud, L; Doerig, C; Gray, N; Meijer, L | 1 |
| Berndt, N; Dohadwala, M; Liu, CW; Schönthal, AH; Villa-Moruzzi, E; Wang, RH | 1 |
| Choi, KS; Eom, YW; Ha, MJ; Kang, Y; Kim, SJ; Rhee, H; Yoon, JW | 1 |
| Baldassarre, G; Barone, MV; Belletti, B; Boccia, A; Bruni, P; Fusco, A; Pepe, S; Romano, A; Sandomenico, C; Spiezia, S; Vento, MT; Viglietto, G | 1 |
| David-Pfeuty, T | 1 |
| Blow, JJ; Gautier, J; Laskey, RA; Madine, MA; Marr, J; Romanowski, P; Rowles, A | 1 |
| Awasthi, S; Awasthi, V; King, RJ; Smith, DB; Vivekananda, J | 1 |
| Prigge, ST; Waters, NC; Woodard, CL | 1 |
| Bisgrove, SR; Bouget, FY; Corellou, F; Kloareg, B; Kropf, DL; Meijer, L | 1 |
| Bertout, M; Bodart, JF; Browaeys, E; Flament, S; Rousseau, A; Vilain, JP | 1 |
| Atienza, C; Dong, YB; Elliott, MJ; Liu, TJ; McMasters, KM; Stilwell, A; Yang, HL | 1 |
| Edamatsu, H; Gau, CL; Guo, L; Nemoto, T; Tamanoi, F | 1 |
| Jin, YH; Lee, SK; Lee, YH; Yoo, KJ | 1 |
| Capraro, HG; Furet, P; Imbach, P; Meyer, T; Zimmermann, J | 1 |
| Guimond, A; O'Connor-McCourt, MD; Zwaagstra, JC | 1 |
| Arnaud, L; Klompmaker, R; Medema, RH; Nigg, EA; Rijksen, G; Smits, VA | 1 |
| Lu, K; Shih, C; Teicher, BA | 1 |
| Flaherty, DB; Soria, JP; Tomasiewicz, HG; Wood, JG | 1 |
| Agid, Y; Lambeng, N; Michel, PP; Ruberg, M | 1 |
| Fukuda, A; Ikeda, M; Morita, M; Shimada, Y; Takagi, M | 1 |
| Haidweger, E; Novy, M; Rotheneder, H | 1 |
| Bouget, FY; Brownlee, C; Corellou, F; Detivaud, L; Kloareg, B | 1 |
| Eisen, H; Engel, JC; Gómez, EB; Laría, S; Santori, MI; Swindle, J; Szankasi, P; Téllez-Iñón, MT | 1 |
| Bibb, JA; Chen, J; Greengard, P; Nairn, AC; Nestler, EJ; Nishi, A; Ouimet, CC; Sagawa, ZK; Snyder, GL; Svenningsson, P; Taylor, JR; Yan, Z | 1 |
| Gouldsworthy, A; Hajdúch, M; Halada, P; Korínková, G; Kovárová, H; Krupicková, S; Strnad, M; Zhelev, N | 1 |
| Miyata, Y; Nagano, M; Piao, Z; Suzuki, H; Ui-Tei, K | 1 |
| Bang, YJ; Hong, SH; Jong, HS; Kim, NK; Kim, SG; Kim, SJ; Kim, SN | 1 |
| Müllbacher, A; Waring, P | 1 |
| Doerig, C; Gray, N; Harmse, L; Havlik, I; Leclerc, S; Meijer, L; Schultz, P; van Zyl, R | 1 |
| Bhide, PG; Bruck, W; Dirnagl, U; Endres, M; Gertz, K; Harms, C; Hauck, L; Hirt, L; Hortnagl, H; Katchanov, J; Priller, J; von Harsdorf, R; Waeber, C | 1 |
| Bouget, FY; Brownlee, C; Corellou, F; Kloareg, B | 1 |
| Milton, NG | 2 |
| Kräusslich, HG; Müller, B; Patschinsky, T | 1 |
| Berneman, ZN; Havlícek, L; Krystof, V; Lenjou, M; Nijs, G; Rodrigus, I; Stockman, B; Strnad, M; Van Bockstaele, DR; Van der Aa, A; van Onckelen, H; Vermeulen, K | 1 |
| Li, ST; Matsui, H; Matsushita, M; Moriwaki, A; Ohta, J; Takei, K; Tomizawa, K | 1 |
| Furukawa, T; Inagaki, N; Katayama, Y; Nakaya, H; Ogura, T; Tsuchiya, H; Zheng, YJ | 1 |
| Balthazar-Stablein, U; Beyer, B; Duncan, R; Green, GR; Kostacos, M; Lukoma, M; Poccia, D; Stephens, S | 1 |
| Borutaite, V; Tolkovsky, AM; Xue, L | 1 |
| Hajdúch, M; Hlobilková, A; Kolár, Z; Lenobel, R; Lukesová, M; Mad'arová, J; Murray, PG; Perera, S; Strnad, M; Vojtesek, B | 1 |
| Burstyn-Cohen, T; Kalcheim, C | 1 |
| Bock, KW; Budt, S; Dietrich, C; Faust, D; Kunz, A; Moskwa, M; Oesch, F | 1 |
| Havlícek, L; Krystof, V; Kuzma, M; Lenobel, R; Strnad, M | 1 |
| Cui, H; Fedoroff, NV | 1 |
| Han, Y; Jiang, HN; Sun, XS; Tan, JH; Yu, YS; Zhao, CB | 1 |
| Bain, J; Cohen, P; Elliott, M; McLauchlan, H | 1 |
| Bartos, J; Kylarová, D; Lichnovský, V; Mad'arová, J; Procházková, J | 1 |
| Chan, WK; Ortiz, D; Pimenta, AF; Shea, TB; Yabe, JT | 1 |
| Dolezal, K; Malon, M; Marek, J; Strnad, M; Trávnícek, Z; Zatloukal, M | 1 |
| Chung, BY; Kim, DC; Kim, DJ; Lee, YR; Shin, KJ; Yang, BS; Yoo, KH | 1 |
| Belejová, M; Brejcha, A; Cerný, B; Cervenková, K; Chmela, Z; Fuksová, K; Hanus, J; Havlícek, L; Michalíková, K; Michnová, K; Riegrová, D; Rypka, M; Súrová, I; Veselý, J | 1 |
| Calegari, F; Huttner, WB | 1 |
| Alemany, C; Ciudad, CJ; Noé, V; Peñuelas, S | 1 |
| Sharma, MC; Sharma, MR; Tuszynski, GP | 1 |
| Balda, MS; Blatch, GL; Chapple, JP; Cheetham, ME; Longshaw, VM | 1 |
| Ahn, JS; Kosik, KS; Mapelli, M; Musacchio, A; Ni, J; Scinto, L; Stein, R; Yeh, LA | 1 |
| Boix, J; Ribas, J | 1 |
| Beaman-Hall, CM; Mathur, A; Monaco, EA; Vallano, ML | 1 |
| Beffert, U; Brady, ST; Brown, H; DeBoer, S; Morfini, G; Pant, HC; Pigino, G; Szebenyi, G | 1 |
| Goshima, Y; Kawakami, T; Li, C; Nakamura, F; Ohshima, T; Sasaki, Y; Shouji, M; Sugiyama, Y; Takei, K; Yagi, T; Yamamoto, H | 1 |
| Bu, B; Chakrabarty, P; Li, J; Vincent, I; Zhang, M | 1 |
| Chan, WK; Dickerson, A; Malik, K; Moran, CM; Motil, J; Ortiz, D; Pant, HC; Pimenta, AF; Shea, TB; Snyder, SJ | 1 |
| Alemany, C; Blasco, F; Calbó, J; Cascalló, M; Ciudad, CJ; Gómez, A; Hernández, JL; Masa, M; Mazo, A; Nicolás, M; Noé, V; Peñuelas, S; Pérez-Torras, S; Piulats, J; Soler, M; Tarrasón, G | 1 |
| Bouchal, J; Hlobilková, A; Knillová, J; Kolár, Z; Strnad, M | 1 |
| Enders, GH; Maude, SL | 1 |
| Corcoran, GB; Gautam, SC; Groc, L; Hunter, TJ; Jiang, H; Koubi, D; Kuo, J; Kuo, K; Levine, RA; Rodriguez, AI; Seidman, MD; Zhang, L | 1 |
| Anghelescu, M; Buraei, Z; Elmslie, KS | 1 |
| Barrie, SE; Brunton, L; Clarke, SJ; Eccles, S; Fischer, PM; Garrett, MD; Kelland, LR; Lane, DP; McClue, S; Raynaud, FI; Rogers, P; Valenti, M; Walton, MI; Whittaker, SR; Workman, P | 1 |
| Grossmann, R; Sirotkin, AV | 1 |
| Byrnes, KR; Cernak, I; Di Giovanni, S; Faden, AI; Stoica, B | 1 |
| Arcuri, HA; Canduri, F; da Silveira, NJ; de Azevedo, WF; Manhani, KK; Uchôa, HB | 1 |
| Bowser, R; Caltagarone, J; Smith, MA; Yu, X | 1 |
| Lu, YF; Matsui, H; Matsushita, M; Mikoshiba, K; Nagashima, K; Ohshima, T; Saheki, Y; Seino, Y; Tomizawa, K; Wei, FY; Yamada, Y | 1 |
| Jaruchotikamol, A; Nemoto, N; Sakuma, T; Tamaki, H; Uchida, Y | 1 |
| Boix, J; Gomez-Arbones, X; Ribas, J | 1 |
| Krystof, V; Sipl, M; Trávnícek, Z | 1 |
| André, P; Appert-Collin, A; Coupin, G; Gies, JP; Hugel, B; Levy, R; Lombard, Y; Niederhoffer, N; Poindron, P | 1 |
| Binnun, E; Mansour, T; Wacharasindhu, S; Wan, ZK | 1 |
| Tian, DS; Wang, P; Wang, W; Xie, MJ; Xu, YL; Yu, ZY; Zhang, GB | 1 |
| Cho, S; Meriney, SD | 1 |
| Bu, BT; Tian, DS; Wang, W; Witte, OW; Xie, MJ; Yu, ZY | 1 |
| Asad, Y; Moreno-Farre, J; Pacey, S; Raynaud, FI; Workman, P | 1 |
| Schmid, G; Strosznajder, JB; Wesierska-Gadek, J | 1 |
| Akashiba, H; Matsuki, N; Nishiyama, N | 1 |
| Castelli, LA; Konstantopoulos, N; Kyi, S; Macaulay, SL; Marcuccio, S; Stoichevska, V; Ward, CW | 1 |
| Chen, B; Chen, C; Tian, DS; Wang, W; Wang, YH; Xie, MJ; Yu, ZY; Zhang, Q | 1 |
| Bu, B; Tian, D; Wang, W; Xie, M; Yu, Z; Zhang, L; Zhang, Q; Zhu, S; Zhu, Z | 1 |
| Bibb, JA; Lynch, WJ; Nestler, EJ; Olausson, P; Sanchez, H; Taylor, JR | 1 |
| Dong, Q; He, Y; Pan, DJ; Tian, DS; Wang, W; Xie, MJ; Yu, ZY | 1 |
| Chen, HX; Du, XP; Sun, MZ; Tian, DS; Wang, W; Xie, MJ; Yu, ZY | 1 |
| Gueorguieva, M; Kramer, MP; Lindner, H; Ranftler, C; Sarg, B; Wesierska-Gadek, J | 1 |
| Sera, T | 1 |
| Bu, BT; Redecker, C; Tian, DS; Wang, W; Witte, OW; Xie, MJ; Yu, ZY; Zhang, L | 1 |
| Gao, CY; Stepp, MA; Tripathi, BK; Zelenka, PS | 1 |
| Bertotto, ME; Bignante, EA; Bussolino, DF; Mlewski, EC; Molina, VA; Paglini, G; Rodriguez Manzanares, PA | 1 |
| Atanasov, AG; Brunner, T; Corazza, N; Leiser, D; Noti, M; Roesselet, C; Schoonjans, K | 1 |
| Hajek, SB; Lindner, H; Sarg, B; Walzi, E; Wandl, S; Wesierska-Gadek, J | 1 |
| An, R; Hagiya, Y; Ishikawa, T; Li, S; Saito, H; Tamura, A; Tokushima, D | 1 |
| Hashimoto, K; Hisanaga, S; Izumi, T; Mori, M; Ohshima, K; Okada, S; Pessin, JE; Saito, T; Shimizu, H; Tatei, K; Tsuchiya, T; Uehara, Y; Yamada, E; Yamada, M; Yamauchi, K | 1 |
| Guo, YJ; Liu, X; Mei, YW; Zhou, Y | 1 |
| Chang, CI; Huang, HC; Jhou, RS; Lu, SY; Sun, GH; Sun, KH; Tang, SJ; Wang, HH | 1 |
| Fei, XF; Fukunaga, K; Han, F; Li, LY; Liang, ZQ; Qin, ZH; Xiang, B | 1 |
| Cruz, M; Siden, A; Tasat, DR; Vita, MF; Yakisich, JS | 1 |
| Wandl, S; Wesierska-Gadek, J | 1 |
| Tripathi, BK; Zelenka, PS | 1 |
| Choi, HS; Chung, SH | 1 |
| Bentke, A; Laidler, P; Małecki, JM; Ostrowska, B | 1 |
| Cwiertka, K; Dzubak, P; Hajduch, M; Korinkova, G; Paprskarova, M | 1 |
| Byun, MR; Choi, JS; Koo, KT; Lee, SK; Lee, WH; Shin, S; Surh, YJ | 1 |
| Bignante, EA; Molina, VA; Paglini, G | 1 |
| Makarevich, AV; Rafay, J; Sirotkin, AV | 1 |
| Hermosilla, V; Iribarren, C; Morin, V; Puchi, M | 1 |
| Akashi, H; Gong, H; Horimoto, T; Ishiwa, A; Iwanaga, T; Kato, K; Kobayashi, K; Murakoshi, F; Recuenco, FC; Sugi, T; Takemae, H | 1 |
| Guan, JX; Lu, ZN; Zeng, YP; Zhou, Q; Zhou, Y | 1 |
| Hsieh, CC; Jhou, RS; Lin, TI; Liu, HY; Lu, SY; Sun, GH; Sun, KH; Tang, SJ; Tsou, YC; Wang, HH | 1 |
| Hyun, HW; Kim, JE; Min, SJ | 1 |
| Djukic, ND; Jayaseelan, JSP; Muyderman, H; Sims, NR; Woodman, RJ; Yew, WP | 1 |
6 review(s) available for kinetin and olomoucine
| Article | Year |
|---|---|
Chemical inhibitors of cyclin-dependent kinases.
Topics: 4-Butyrolactone; Animals; Cell Cycle; Cyclin-Dependent Kinases; Enzyme Inhibitors; Flavonoids; Humans; Kinetin; Piperidines; Purines; Staurosporine; Suramin | 1995 |
The structure-based design of ATP-site directed protein kinase inhibitors.
Topics: Adenosine Triphosphate; Adenylyl Imidodiphosphate; Anthraquinones; Binding Sites; Catalytic Domain; Cyclin-Dependent Kinases; Drug Design; Enzyme Inhibitors; Humans; Kinetin; Piperazines; Protein-Tyrosine Kinases; Purines; Pyridines; Pyrimidines; Pyrroles; Quinazolines; Receptors, Growth Factor; Roscovitine; Staurosporine; Structure-Activity Relationship | 1999 |
ATP-site directed inhibitors of cyclin-dependent kinases.
Topics: Adenine; Adenosine Triphosphate; Amino Acid Sequence; Antineoplastic Agents; Binding Sites; Cell Cycle; Cyclin-Dependent Kinases; Drug Design; Enzyme Inhibitors; Flavonoids; Humans; Isopentenyladenosine; Kinetin; Molecular Sequence Data; Piperidines; Purines; Roscovitine; Sequence Alignment; Sequence Homology, Amino Acid; Staurosporine; Suramin | 1999 |
Phosphorylated amyloid-beta: the toxic intermediate in alzheimer's disease neurodegeneration.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cyclin-Dependent Kinases; Enzyme Inhibitors; Humans; Kinetin; Nerve Degeneration; Phosphoproteins; Phosphorylation; Purines | 2005 |
Interplay between the p53 tumor suppressor protein family and Cdk5: novel therapeutic approaches for the treatment of neurodegenerative diseases using selective Cdk inhibitors.
Topics: Animals; Apoptosis; Brain Ischemia; Cell Cycle; Cyclin-Dependent Kinase 5; Humans; Kinetin; Neurodegenerative Diseases; Neurons; Protein Kinase Inhibitors; Purines; Roscovitine; Tumor Suppressor Protein p53 | 2006 |
[Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors].
Topics: Adenine; Cell Division; Cyclin-Dependent Kinases; Drug Design; Drug Evaluation, Preclinical; Enzyme Inhibitors; Genomics; Humans; Kinetin; Ligands; Microarray Analysis; Small Molecule Libraries; Tumor Cells, Cultured | 2007 |
165 other study(ies) available for kinetin and olomoucine
| Article | Year |
|---|---|
Multiple modes of ligand recognition: crystal structures of cyclin-dependent protein kinase 2 in complex with ATP and two inhibitors, olomoucine and isopentenyladenine.
Topics: Adenine; Adenosine Triphosphate; Amino Acid Sequence; CDC2-CDC28 Kinases; Crystallography, X-Ray; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Enzyme Inhibitors; Humans; Isopentenyladenosine; Kinetin; Ligands; Models, Molecular; Molecular Conformation; Molecular Sequence Data; Protein Kinases; Protein Serine-Threonine Kinases; Purines; Surface Properties | 1995 |
Olomoucine, an inhibitor of the cdc2/cdk2 kinases activity, blocks plant cells at the G1 to S and G2 to M cell cycle transitions.
Topics: Arabidopsis; Bisbenzimidazole; Bromodeoxyuridine; CDC2 Protein Kinase; CDC2-CDC28 Kinases; Cell Cycle; Cells, Cultured; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; G1 Phase; G2 Phase; Kinetin; Mitosis; Plant Cells; Plants; Propidium; Protein Serine-Threonine Kinases; Purines; S Phase; Staining and Labeling | 1994 |
Cellular effects of olomoucine, an inhibitor of cyclin-dependent kinases.
Topics: Animals; Cell Cycle; Cyclin-Dependent Kinases; Enzyme Inhibitors; Growth Inhibitors; Humans; In Vitro Techniques; Kinetin; Lymphocyte Activation; Mitosis; Oocytes; Purines; T-Lymphocytes; Tumor Cells, Cultured | 1995 |
Inhibitors of cyclin-dependent kinases promote survival of post-mitotic neuronally differentiated PC12 cells and sympathetic neurons.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle; Cell Differentiation; Cell Survival; Cells, Cultured; Culture Media; Cyclin-Dependent Kinases; Enzyme Activation; Enzyme Inhibitors; Flavonoids; JNK Mitogen-Activated Protein Kinases; Kinetin; Mitogen-Activated Protein Kinases; Nerve Growth Factors; Nerve Tissue Proteins; PC12 Cells; Piperidines; Purines; Rats; Sympathetic Nervous System | 1996 |
Evidence for phosphorylation of CTP:phosphocholine cytidylyltransferase by multiple proline-directed protein kinases.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; CDC2 Protein Kinase; Cell Line; Cell-Free System; Choline-Phosphate Cytidylyltransferase; Enzyme Activation; Enzyme Inhibitors; Humans; Kinetin; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nucleotidyltransferases; Oleic Acid; Oleic Acids; Phosphopeptides; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins p21(ras); Purines; Transfection | 1996 |
Evidence that the endogenous histone H1 phosphatase in HeLa mitotic chromosomes is protein phosphatase 1, not protein phosphatase 2A.
Topics: Cell Nucleus; Chromatin; Enzyme Inhibitors; HeLa Cells; Histones; Humans; Kinetin; Marine Toxins; Metaphase; Microcystins; Mitosis; Okadaic Acid; Oxazoles; Peptides, Cyclic; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase Inhibitors; Protein Phosphatase 1; Protein Phosphatase 2; Purines; Staurosporine | 1996 |
Plasmodium falciparum protein kinase 5 and the malarial nuclear division cycles.
Topics: Animals; Aphidicolin; CDC2 Protein Kinase; Cell Nucleus; DNA, Protozoan; Enzyme Inhibitors; Flavonoids; Kinetin; Piperidines; Plasmodium falciparum; Protozoan Proteins; Purines; RNA, Protozoan; S Phase | 1996 |
Phosphorylation and activation of p42 and p44 mitogen-activated protein kinase are required for the P2 purinoceptor stimulation of endothelial prostacyclin production.
Topics: Adenosine Triphosphate; Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cattle; Cells, Cultured; Chromatography, Ion Exchange; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Epoprostenol; Flavonoids; Kinetin; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Protein-Tyrosine Kinases; Purines; Receptors, Purinergic P2; Type C Phospholipases | 1996 |
G1/S cell cycle blockers and inhibitors of cyclin-dependent kinases suppress camptothecin-induced neuronal apoptosis.
Topics: Animals; Apoptosis; Camptothecin; Cell Differentiation; Cell Division; Cyclin-Dependent Kinases; Enzyme Inhibitors; Flavonoids; G1 Phase; Growth Inhibitors; Humans; Kinetin; Neurons; PC12 Cells; Piperidines; Purines; Rats; S Phase; Sympathetic Nervous System | 1997 |
2-Aminopurine induces spindle cell morphology in MM14 myoblasts in the absence of differentiation signals.
Topics: 2-Aminopurine; Actins; Animals; Cell Differentiation; Cell Line; Cyclin-Dependent Kinases; GTP Phosphohydrolases; HL-60 Cells; Humans; Kinetin; Mice; Microtubules; Muscles; PC12 Cells; Protein Synthesis Inhibitors; Purines; Rats; Signal Transduction; Spindle Apparatus | 1997 |
Inhibition of cyclin-dependent kinases by purine analogues: crystal structure of human cdk2 complexed with roscovitine.
Topics: Adenosine Triphosphate; Animals; Binding Sites; CDC2 Protein Kinase; CDC2-CDC28 Kinases; Crystallography, X-Ray; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Humans; Hydrogen Bonding; Kinetin; Ligands; Models, Molecular; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Purines; Roscovitine; Starfish | 1997 |
Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Animals; Antineoplastic Agents; Apoptosis; Binding Sites; Calcium-Calmodulin-Dependent Protein Kinases; CDC2 Protein Kinase; CDC2-CDC28 Kinases; Cell Cycle; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Enzyme Inhibitors; Growth Inhibitors; Humans; Kinetin; Leukemia L1210; Maturation-Promoting Factor; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Oogenesis; Phosphorylation; Phosphotyrosine; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Purines; Roscovitine; Sea Urchins; Starfish; Substrate Specificity; Vimentin; Xenopus laevis; Xenopus Proteins | 1997 |
Cytokinin-derived cyclin-dependent kinase inhibitors: synthesis and cdc2 inhibitory activity of olomoucine and related compounds.
Topics: Animals; CDC2 Protein Kinase; CDC28 Protein Kinase, S cerevisiae; Enzyme Inhibitors; Kinetin; Oocytes; Purines; Roscovitine; Starfish; Tumor Cells, Cultured | 1997 |
Cell cycle-dependent phosphorylation of mammalian protein phosphatase 1 by cdc2 kinase.
Topics: 3T3 Cells; Animals; Antibodies; CDC2 Protein Kinase; Cell Cycle; Cell Line; Enzyme Inhibitors; Fluorescent Antibody Technique, Indirect; Kinetin; Mammals; Marine Toxins; Mice; Mitosis; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 1; Purines; Recombinant Proteins; Threonine; Transfection | 1997 |
Noninvasive, real-time method for the examination of thymidine uptake events--application of the method to V-79 cell synchrony studies.
Topics: Animals; Aphidicolin; Biological Transport, Active; CDC2 Protein Kinase; Cell Adhesion; Cell Cycle; Cell Division; Cell Line; Cricetinae; Cytological Techniques; Demecolcine; Kinetin; Purines; Thymidine | 1997 |
Phosphorylation of the tumor suppressor adenomatous polyposis coli (APC) by the cyclin-dependent kinase p34.
Topics: Adenomatous Polyposis Coli; Adenomatous Polyposis Coli Protein; Amino Acid Sequence; Binding Sites; CDC2 Protein Kinase; Consensus Sequence; Cytoskeletal Proteins; Enzyme Inhibitors; Genes, APC; Humans; Kinetin; Molecular Sequence Data; Phosphorylation; Purines; Tumor Cells, Cultured | 1997 |
Lithium inhibits Alzheimer's disease-like tau protein phosphorylation in neurons.
Topics: Alzheimer Disease; Animals; Blotting, Western; Brain; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cyclin-Dependent Kinases; Enzyme Inhibitors; Flavonoids; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Humans; Kinetin; Lithium; Neurons; Okadaic Acid; Phosphorylation; Proline; Purines; Rats; tau Proteins | 1997 |
Cyclin-dependent kinase inhibitors block proliferation of human gastric cancer cells.
Topics: Antineoplastic Agents; CDC2 Protein Kinase; CDC2-CDC28 Kinases; Cell Cycle; Cell Division; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Enzyme Inhibitors; Histones; Humans; Kinetics; Kinetin; Protein Serine-Threonine Kinases; Purines; Roscovitine; Stomach Neoplasms; Substrate Specificity; Tumor Cells, Cultured | 1997 |
Plasma membrane alterations and cytoskeletal changes in apoptosis.
Topics: Actins; Annexin A5; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Membrane; Chromatin; Cytoskeleton; Ethylmaleimide; Humans; Keratins; Kinetin; Lung Neoplasms; Neuroblastoma; Phosphatidylserines; Purines; Roscovitine; Tetradecanoylphorbol Acetate; Tubulin; Tumor Cells, Cultured; Vimentin | 1997 |
Effects of olomoucine, a selective inhibitor of cyclin-dependent kinases, on cell cycle progression in human cancer cell lines.
Topics: Cell Cycle; Cell Division; Cyclin-Dependent Kinases; Enzyme Inhibitors; Humans; Kinetin; Lovastatin; Neoplasms; Purines; Retinoblastoma Protein; Thymidine; Thymidine Kinase; Tritium; Tumor Cells, Cultured | 1997 |
Phosphorylation of the Src substrate Sam68 by Cdc2 during mitosis.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Animals; CDC2 Protein Kinase; Cell Cycle; Cell Extracts; Cyclin B; DNA-Binding Proteins; Enzyme Inhibitors; HeLa Cells; Humans; Interphase; Kinetin; Mice; Mitosis; Phosphorylation; Proto-Oncogene Proteins pp60(c-src); Purines; Recombinant Proteins; RNA-Binding Proteins; Serine; Threonine | 1997 |
Kinase and phosphatase inhibitors cause rapid alterations in microtubule dynamic instability in living cells.
Topics: Animals; Cells, Cultured; Enzyme Inhibitors; Epithelium; Kinetin; Lung; Microscopy, Interference; Microtubules; Okadaic Acid; Phosphorylases; Phosphotransferases; Purines; Salamandridae; Staurosporine; Time Factors | 1997 |
The effect of the cyclin-dependent kinase inhibitor olomoucine on cell cycle kinetics.
Topics: Antimetabolites; Apoptosis; Bromodeoxyuridine; Carcinoma, Non-Small-Cell Lung; CDC2 Protein Kinase; Cell Cycle; Cyclin-Dependent Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flow Cytometry; G2 Phase; Humans; Kinetin; Lung Neoplasms; Mitosis; Neuroblastoma; Purines; Roscovitine; S Phase; Tumor Cells, Cultured | 1997 |
The cyclin-dependent kinase (cdk) inhibitors, olomoucine and roscovitine, alter the expression of a molluscan circadian pacemaker.
Topics: Animals; Biological Clocks; Circadian Rhythm; Cyclin-Dependent Kinases; Cycloheximide; Darkness; Dichlororibofuranosylbenzimidazole; Dose-Response Relationship, Drug; Enzyme Inhibitors; Kinetin; Mollusca; Nucleic Acid Synthesis Inhibitors; Ocular Physiological Phenomena; Photoperiod; Protein Synthesis Inhibitors; Purines; Roscovitine | 1997 |
MAP and cdc2 kinase activities at germinal vesicle breakdown in Chaetopterus.
Topics: Animals; Blotting, Western; Calcimycin; Calcium-Calmodulin-Dependent Protein Kinases; CDC2 Protein Kinase; Enzyme Activation; Enzyme Inhibitors; Fertilization; Flavonoids; Glycogen Synthase Kinase 3; Ionophores; Kinetin; MAP Kinase Kinase 1; Meiosis; Mitogen-Activated Protein Kinase Kinases; Oocytes; Phosphorylation; Phosphotyrosine; Polychaeta; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Purines; Tetradecanoylphorbol Acetate | 1997 |
Induction of apoptosis and regression of spontaneous dog melanoma following in vivo application of synthetic cyclin-dependent kinase inhibitor olomoucine.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cyclin-Dependent Kinases; Dog Diseases; Dogs; Enzyme Inhibitors; Facial Neoplasms; Kinetin; Male; Melanoma; Purines | 1997 |
Multiple pathways of neuronal death induced by DNA-damaging agents, NGF deprivation, and oxidative stress.
Topics: Animals; Antimetabolites, Antineoplastic; Aphidicolin; Apoptosis; Aspartic Acid; Cell Division; Cell Survival; Cyclin-Dependent Kinases; Cysteine Endopeptidases; Cytarabine; DNA Damage; Enzyme Inhibitors; Flavonoids; Humans; Kinetin; Nerve Growth Factors; Neurons; Oxidative Stress; PC12 Cells; Piperidines; Purines; Rats; Rats, Sprague-Dawley; S Phase; Superior Cervical Ganglion; Superoxide Dismutase; Ultraviolet Rays | 1998 |
Early inhibition of DNA synthesis in the developing rat cerebral cortex by the purine analogues olomoucine and roscovitine.
Topics: Animals; Cell Cycle; Cerebral Cortex; Cyclin-Dependent Kinases; DNA; Enzyme Inhibitors; Etoposide; Kinetin; Nucleic Acid Synthesis Inhibitors; Purines; Rats; Rats, Sprague-Dawley; Roscovitine; Staurosporine; Thymidine; Tritium | 1998 |
Differential response of the human cyclin B1 promoter to inhibitors of the cell cycle in NIH3T3 cells.
Topics: 3T3 Cells; Animals; Aphidicolin; Cell Cycle; Cyclin B; Cyclin B1; Cyclin-Dependent Kinases; DNA Replication; Enzyme Inhibitors; Gene Expression Regulation; Humans; Kinetin; Luciferases; Mice; Promoter Regions, Genetic; Purines; Transcriptional Activation | 1998 |
Apoptosis of central and peripheral neurons can be prevented with cyclin-dependent kinase/mitogen-activated protein kinase inhibitors.
Topics: Animals; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Cell Nucleus; Chick Embryo; Cyclin-Dependent Kinases; Ganglia; Kinetin; Neurons; Proto-Oncogene Proteins c-jun; Purines; Rats; Rats, Sprague-Dawley; Retinal Ganglion Cells; Roscovitine | 1998 |
Structural basis for chemical inhibition of CDK2.
Topics: Adenine; Adenosine Triphosphate; Animals; Binding Sites; CDC2-CDC28 Kinases; Cell Cycle; Crystallography, X-Ray; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Isopentenyladenosine; Kinetin; Ligands; Macromolecular Substances; Models, Molecular; Piperidines; Protein Conformation; Protein Serine-Threonine Kinases; Purines; Recombinant Proteins | 1996 |
The crk3 gene of Leishmania mexicana encodes a stage-regulated cdc2-related histone H1 kinase that associates with p12.
Topics: Amino Acid Sequence; Animals; CDC2 Protein Kinase; Enzyme Inhibitors; Genetic Complementation Test; Humans; Kinetin; Leishmania mexicana; Molecular Sequence Data; Mutation; Protein Binding; Protozoan Proteins; Purines; Recombinant Proteins; Sequence Homology, Amino Acid; Temperature | 1998 |
Requirement for cellular cyclin-dependent kinases in herpes simplex virus replication and transcription.
Topics: Amino Acid Sequence; Animals; Cell Cycle; Chlorocebus aethiops; Cyclin-Dependent Kinases; DNA Replication; Kinetin; Molecular Sequence Data; Purines; Roscovitine; Simplexvirus; Transcription, Genetic; Vero Cells; Virus Replication | 1998 |
Cdk2 activity is dispensable for the onset of DNA replication during the first mitotic cycles of the sea urchin early embryo.
Topics: Adenine; Animals; CDC2 Protein Kinase; CDC2-CDC28 Kinases; Cell Cycle; Cloning, Molecular; Cyclin A; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; DNA Replication; Emetine; Enzyme Inhibitors; Fertilization; Fluorescent Antibody Technique; Kinetin; Meiosis; Microinjections; Mitosis; Protein Serine-Threonine Kinases; Purines; Sea Urchins; Sequence Alignment; Sequence Analysis, DNA | 1998 |
A role for cyclin-dependent kinase(s) in the modulation of fast anterograde axonal transport: effects defined by olomoucine and the APC tumor suppressor protein.
Topics: Adenomatous Polyposis Coli; Adenomatous Polyposis Coli Protein; Amino Acid Sequence; Animals; Axonal Transport; Axons; Cyclin-Dependent Kinases; Cytoskeletal Proteins; Decapodiformes; Dose-Response Relationship, Drug; Enzyme Inhibitors; GTP Phosphohydrolases; Histones; Kinetin; Microtubules; Molecular Sequence Data; Nerve Tissue Proteins; Neurofibromin 1; Organelles; Peptide Fragments; Proteins; Purines; Recombinant Proteins | 1998 |
Structural basis of inhibitor selectivity in MAP kinases.
Topics: Adenosine Triphosphate; Calcium-Calmodulin-Dependent Protein Kinases; Catalytic Domain; Cell Differentiation; Cell Division; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Imidazoles; Kinetin; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Models, Chemical; Models, Molecular; p38 Mitogen-Activated Protein Kinases; Protein Conformation; Purines; Pyridines; Pyrimidines; Structure-Activity Relationship | 1998 |
Identification of mitogen-activated protein kinase-activated protein kinase-2 as a vimentin kinase activated by okadaic acid in 9L rat brain tumor cells.
Topics: Animals; Brain Neoplasms; Cytosol; Electrophoresis, Gel, Two-Dimensional; Enzyme Activation; Gliosarcoma; Imidazoles; Intracellular Signaling Peptides and Proteins; Kinetin; Okadaic Acid; Peptide Mapping; Phosphorylation; Protein Serine-Threonine Kinases; Purines; Pyridines; Rats; Tumor Cells, Cultured | 1998 |
The cyclin-dependent kinase inhibitors olomoucine and roscovitine arrest human fibroblasts in G1 phase by specific inhibition of CDK2 kinase activity.
Topics: CDC2-CDC28 Kinases; Cell Line; Cyclin B; Cyclin D1; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinases; DNA; Enzyme Inhibitors; Fibroblasts; G1 Phase; Humans; Kinetin; Phosphorylation; Proliferating Cell Nuclear Antigen; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Purines; Retinoblastoma Protein; Roscovitine | 1998 |
Overexpression of ErbB2 blocks Taxol-induced apoptosis by upregulation of p21Cip1, which inhibits p34Cdc2 kinase.
Topics: Animals; Apoptosis; Breast Neoplasms; CDC2 Protein Kinase; CDC2-CDC28 Kinases; Cell Line; Cyclin B; Cyclin B1; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; DNA Fragmentation; Fibroblasts; Flow Cytometry; Humans; Kinetin; Mice; Oligonucleotides, Antisense; Paclitaxel; Protein Serine-Threonine Kinases; Purines; Receptor, ErbB-2; Transfection; Tumor Cells, Cultured; Up-Regulation | 1998 |
Synthesis of C2 alkynylated purines, a new family of potent inhibitors of cyclin-dependent kinases.
Topics: Alkynes; Animals; CDC2 Protein Kinase; Cyclin B; Cyclin-Dependent Kinases; Enzyme Inhibitors; Female; Kinetin; Oocytes; Purines; Roscovitine; Starfish; Structure-Activity Relationship | 1998 |
The clam 3' UTR masking element-binding protein p82 is a member of the CPEB family.
Topics: 3' Untranslated Regions; Amino Acid Sequence; Animals; Bivalvia; Cloning, Molecular; Cyclin-Dependent Kinases; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation, Developmental; Kinetin; Meiosis; Molecular Sequence Data; Oocytes; Phosphorylation; Protein Biosynthesis; Purines; RNA-Binding Proteins; RNA, Messenger; Sequence Alignment; Sequence Analysis, DNA; Xenopus | 1999 |
Effects of cyclin-dependent kinase inhibitors on transcription and ocular circadian rhythm of Aplysia.
Topics: 4-Butyrolactone; Action Potentials; Animals; Aplysia; Circadian Rhythm; Cyclin-Dependent Kinases; Electrophysiology; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Kinetin; Macromolecular Substances; Neural Conduction; Ocular Physiological Phenomena; Purines; RNA, Messenger; Roscovitine; Transcription, Genetic | 1999 |
Regulation of exocytosis by cyclin-dependent kinase 5 via phosphorylation of Munc18.
Topics: Animals; Brain Chemistry; Consensus Sequence; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Enzyme Inhibitors; Exocytosis; In Vitro Techniques; Kinetin; Macromolecular Substances; Membrane Proteins; Mice; Molecular Weight; Munc18 Proteins; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Phosphorylation; Purines; Qa-SNARE Proteins; Rats; Recombinant Proteins; Synaptic Vesicles; Syntaxin 1; Vesicular Transport Proteins | 1999 |
2,6,9-trisubstituted purines: optimization towards highly potent and selective CDK1 inhibitors.
Topics: Antineoplastic Agents; CDC2 Protein Kinase; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Epidermal Growth Factor; Humans; Isoenzymes; Kinetin; Protein Kinase C; Protein Kinase C-alpha; Purines; Structure-Activity Relationship | 1999 |
HLA class I-mediated induction of cell proliferation involves cyclin E-mediated inactivation of Rb function and induction of E2F activity.
Topics: Carrier Proteins; Cell Cycle Proteins; Cell Division; Cells, Cultured; Cyclin E; Cyclin-Dependent Kinases; DNA-Binding Proteins; E2F Transcription Factors; Endothelium, Vascular; Enzyme Activation; fas Receptor; Growth Inhibitors; Histocompatibility Antigens Class I; HLA Antigens; Humans; Imidazoles; Jurkat Cells; Kinetin; Purines; Pyridines; Receptors, Fibroblast Growth Factor; Retinoblastoma Protein; Retinoblastoma-Binding Protein 1; Signal Transduction; T-Lymphocytes; Transcription Factor DP1; Transcription Factors | 1999 |
ERK pathway mediates the activation of Cdk2 in IGF-1-induced proliferation of human osteosarcoma MG-63 cells.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; CDC2-CDC28 Kinases; Cell Cycle; Cell Division; Cyclin A; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Enzyme Activation; Flavonoids; Humans; Insulin-Like Growth Factor I; Kinetin; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; Osteoblasts; Phosphorylation; Protein Serine-Threonine Kinases; Purines; Retinoblastoma Protein; Signal Transduction; Tumor Cells, Cultured | 1999 |
Transient hypoxia may lead to neuronal proliferation in the developing mammalian brain: from apoptosis to cell cycle completion.
Topics: Animals; Apoptosis; Brain; Cell Cycle; Cell Division; Cells, Cultured; Culture Media; Cyclin-Dependent Kinases; DNA; Enzyme Inhibitors; Female; Hypoxia, Brain; Immunohistochemistry; Kinetin; Nerve Tissue Proteins; Neurons; Pregnancy; Proliferating Cell Nuclear Antigen; Purines; Rats; Reperfusion Injury | 1999 |
Inhibition of HIV replication by dominant negative mutants of Sam68, a functional homolog of HIV-1 Rev.
Topics: Adaptor Proteins, Signal Transducing; Antibodies; Carrier Proteins; Cells, Cultured; Chloramphenicol O-Acetyltransferase; Cytoplasm; DNA-Binding Proteins; Enzyme Inhibitors; Exportin 1 Protein; Fatty Acids, Unsaturated; Gene Expression Regulation, Viral; Gene Products, rev; Genes, Dominant; Genes, Reporter; HeLa Cells; HIV-1; Humans; Karyopherins; Kinetin; Mutation; Purines; Receptors, Cytoplasmic and Nuclear; Response Elements; rev Gene Products, Human Immunodeficiency Virus; RNA-Binding Proteins; Virus Replication | 1999 |
CDK-inhibitor olomoucine inhibits cell death after exposure of cell lines to cytosine-arabinoside.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Cyclin-Dependent Kinases; Cytarabine; DNA; DNA Fragmentation; Enzyme Inhibitors; HeLa Cells; Humans; Kinetin; Purines; Signal Transduction | 1999 |
Auxin induction of cell cycle regulated activity of tobacco telomerase.
Topics: Aphidicolin; CDC2-CDC28 Kinases; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; DNA Polymerase I; DNA Replication; Enzyme Activation; Enzyme Inhibitors; Hydroxyurea; Indoleacetic Acids; Kinetin; Nicotiana; Plants, Toxic; Protein Serine-Threonine Kinases; Purines; Ribonucleotide Reductases; S Phase; Telomerase | 1999 |
The use of beta, gamma-methyleneadenosine 5'-triphosphate to determine ATP competition in a scintillation proximity kinase assay.
Topics: Adenosine Triphosphate; Binding, Competitive; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Indoles; Kinetics; Kinetin; Protein Kinase Inhibitors; Purines; Scintillation Counting; Staurosporine | 1999 |
Synthesis and in vitro evaluation of novel 2,6,9-trisubstituted purines acting as cyclin-dependent kinase inhibitors.
Topics: CDC2 Protein Kinase; CDC2-CDC28 Kinases; Cell Cycle; Cell Death; Cell Survival; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Drug Evaluation, Preclinical; Enzyme Inhibitors; HeLa Cells; Humans; Inhibitory Concentration 50; Kinetin; Lethal Dose 50; Nucleosides; Protein Serine-Threonine Kinases; Purines; S Phase; Structure-Activity Relationship; Thymidine | 1999 |
Inhibitory phosphorylation of PP1alpha catalytic subunit during the G(1)/S transition.
Topics: CDC2-CDC28 Kinases; Cell Cycle; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Enzyme Inhibitors; G1 Phase; Humans; Immunoblotting; Kinetin; Phosphoprotein Phosphatases; Phosphorylation; Phosphothreonine; Protein Serine-Threonine Kinases; Purines; Recombinant Proteins; Retinoblastoma Protein; S Phase; Tumor Cells, Cultured | 1999 |
Cdc2 and Cdk2 kinase activated by transforming growth factor-beta1 trigger apoptosis through the phosphorylation of retinoblastoma protein in FaO hepatoma cells.
Topics: Animals; Apoptosis; CDC2 Protein Kinase; CDC2-CDC28 Kinases; Cell Cycle; Cell Death; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Enzyme Activation; Enzyme Inhibitors; Kinetin; Liver Neoplasms, Experimental; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-bcl-2; Purines; Rats; Retinoblastoma Protein; RNA, Messenger; Roscovitine; Transforming Growth Factor beta; Tumor Cells, Cultured | 1999 |
Key role of the cyclin-dependent kinase inhibitor p27kip1 for embryonal carcinoma cell survival and differentiation.
Topics: Acetamides; Antigens, Neoplasm; Antigens, Surface; Antigens, Tumor-Associated, Carbohydrate; Apoptosis; Carcinoma, Embryonal; CDC2-CDC28 Kinases; Cell Cycle Proteins; Cell Differentiation; Cell Survival; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cyclins; Gene Expression Regulation, Neoplastic; Glycosphingolipids; Humans; Kinetin; Macromolecular Substances; Microtubule-Associated Proteins; Neoplasm Proteins; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Purines; Retinoblastoma Protein; Roscovitine; Stage-Specific Embryonic Antigens; Tumor Cells, Cultured; Tumor Suppressor Proteins | 1999 |
Potent inhibitors of cyclin-dependent kinase 2 induce nuclear accumulation of wild-type p53 and nucleolar fragmentation in human untransformed and tumor-derived cells.
Topics: Blotting, Western; Breast Neoplasms; Carcinoma; CDC2-CDC28 Kinases; Cell Cycle; Cell Death; Cell Line; Cell Line, Transformed; Cell Nucleolus; Cell Nucleus; Cell Transformation, Neoplastic; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme Inhibitors; G1 Phase; Humans; Inhibitory Concentration 50; Kinetin; Mitomycin; Nucleic Acid Synthesis Inhibitors; Nucleolin; Phosphoproteins; Protein Serine-Threonine Kinases; Purines; RNA-Binding Proteins; Roscovitine; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1999 |
Interaction of Xenopus Cdc2 x cyclin A1 with the origin recognition complex.
Topics: Adenine; Animals; CDC2 Protein Kinase; Cyclin A; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA Replication; DNA-Binding Proteins; Enzyme Inhibitors; Kinetin; Origin Recognition Complex; Phosphorylation; Precipitin Tests; Protein Kinases; Purines; Xenopus; Xenopus Proteins | 2000 |
Hepatocyte growth factor is elevated in chronic lung injury and inhibits surfactant metabolism.
Topics: Animals; Choline-Phosphate Cytidylyltransferase; Chronic Disease; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Hepatocyte Growth Factor; Interleukin-1; Kinetin; Lung; Lung Diseases; Mitogen-Activated Protein Kinases; Oxidative Stress; Phosphatidylcholines; Protein Kinases; Pulmonary Surfactants; Purines; Rats; RNA, Messenger; Transcription, Genetic; Tumor Necrosis Factor-alpha | 2000 |
Cyclin H activation and drug susceptibility of the Pfmrk cyclin dependent protein kinase from Plasmodium falciparum.
Topics: Amino Acid Sequence; Animals; Cyclin H; Cyclin-Dependent Kinase-Activating Kinase; Cyclin-Dependent Kinases; Cyclins; Enzyme Inhibitors; Humans; Kinetin; Models, Molecular; Molecular Sequence Data; Plasmodium falciparum; Protein Conformation; Protein Kinases; Protein Serine-Threonine Kinases; Purines; Roscovitine | 2000 |
A S/M DNA replication checkpoint prevents nuclear and cytoplasmic events of cell division including centrosomal axis alignment and inhibits activation of cyclin-dependent kinase-like proteins in fucoid zygotes.
Topics: Aphidicolin; Cell Division; Cell Nucleus; Centrosome; Cyclin-Dependent Kinases; Cytoplasm; DNA Polymerase I; DNA Polymerase III; DNA Replication; Enzyme Activation; Enzyme Inhibitors; Kinetin; Mitosis; Morphogenesis; Phaeophyceae; Purines; S Phase; Signal Transduction; Spindle Apparatus; Tyrosine; Zygote | 2000 |
Differential effects of 6-DMAP, olomoucine and roscovitine on Xenopus oocytes and eggs.
Topics: Adenine; Animals; Blotting, Western; CDC2 Protein Kinase; Cyclin B; Cyclin-Dependent Kinases; Enzyme Inhibitors; Female; In Vitro Techniques; Kinetin; Meiosis; Microinjections; Mitogen-Activated Protein Kinase 1; Oocytes; Ovum; Protein Kinases; Purines; Roscovitine; Xenopus laevis | 2000 |
Adenovirus-mediated E2F-1 gene transfer induces an apoptotic response in human gastric carcinoma cells that is enhanced by cyclin dependent kinase inhibitors.
Topics: Adenoviridae; Apoptosis; bcl-2-Associated X Protein; Carrier Proteins; Caspases; CDC2 Protein Kinase; CDC2-CDC28 Kinases; Cell Cycle; Cell Cycle Proteins; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; DNA-Binding Proteins; E2F Transcription Factors; E2F1 Transcription Factor; Enzyme Inhibitors; Gene Transfer Techniques; Humans; Kinetin; Poly(ADP-ribose) Polymerases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Purines; Retinoblastoma-Binding Protein 1; Roscovitine; Stomach Neoplasms; Transcription Factor DP1; Transcription Factors; Tumor Cells, Cultured | 2000 |
Cdk inhibitors, roscovitine and olomoucine, synergize with farnesyltransferase inhibitor (FTI) to induce efficient apoptosis of human cancer cell lines.
Topics: Alkyl and Aryl Transferases; Apoptosis; Benzazepines; Caspases; Cell Line; Chromones; Cyclin-Dependent Kinases; Cytochrome c Group; Cytosol; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Farnesyltranstransferase; HL-60 Cells; Humans; Kinetin; Mitochondria; Morpholines; Phosphorylation; Purines; Retinoblastoma Protein; Roscovitine | 2000 |
Caspase 3-mediated cleavage of p21WAF1/CIP1 associated with the cyclin A-cyclin-dependent kinase 2 complex is a prerequisite for apoptosis in SK-HEP-1 cells.
Topics: Apoptosis; Caspase 3; Caspases; CDC2-CDC28 Kinases; Cell Cycle Proteins; Cyclin A; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cyclins; Endothelium, Vascular; Enzyme Activation; Ginsenosides; Humans; Kinetin; Microtubule-Associated Proteins; Mutation; Protein Serine-Threonine Kinases; Purines; Saponins; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2000 |
Structure-based design of potent CDK1 inhibitors derived from olomoucine.
Topics: Amino Acid Sequence; Binding Sites; CDC2 Protein Kinase; CDC2-CDC28 Kinases; Computer-Aided Design; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Drug Design; Enzyme Inhibitors; Humans; Kinetin; Models, Molecular; Molecular Sequence Data; Protein Conformation; Protein Serine-Threonine Kinases; Purines; Sequence Homology, Amino Acid | 2000 |
Predominant intracellular localization of the type I transforming growth factor-beta receptor and increased nuclear accumulation after growth arrest.
Topics: Activin Receptors, Type I; Animals; Cell Cycle; Cell Line; Cell Membrane; Cell Nucleus; Cyclin-Dependent Kinases; Endoplasmic Reticulum; Enzyme Inhibitors; Gene Expression Regulation; Golgi Apparatus; Green Fluorescent Proteins; Humans; Kinetin; Luminescent Proteins; Lung Neoplasms; Mink; Protein Serine-Threonine Kinases; Purines; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Recombinant Fusion Proteins; Respiratory Mucosa; Signal Transduction; Transfection; Transforming Growth Factor beta; Tumor Cells, Cultured | 2000 |
Polo-like kinase-1 is a target of the DNA damage checkpoint.
Topics: CDC2 Protein Kinase; cdc25 Phosphatases; Cell Cycle Proteins; Cyclin B; Cyclin-Dependent Kinases; DNA Damage; Enzyme Inhibitors; Humans; Kinetin; Mitosis; Polo-Like Kinase 1; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Purines; Signal Transduction; Tumor Cells, Cultured | 2000 |
Expression of pRB, cyclin/cyclin-dependent kinases and E2F1/DP-1 in human tumor lines in cell culture and in xenograft tissues and response to cell cycle agents.
Topics: Aged; Animals; Antineoplastic Agents; Blotting, Western; Calmodulin-Binding Proteins; Cell Cycle; Cell Cycle Proteins; Cell Survival; Cyclin-Dependent Kinases; Cyclins; Enzyme Inhibitors; Female; Flavonoids; Genistein; Humans; Kinetin; Male; Mice; Mice, Nude; Middle Aged; Neoplasm Transplantation; Piperidines; Plant Proteins; Purines; Transcription Factor DP1; Transcription Factors; Transplantation, Heterologous; Tumor Cells, Cultured | 2000 |
Phosphorylation of human tau protein by microtubule-associated kinases: GSK3beta and cdk5 are key participants.
Topics: Adenosine Triphosphate; Alzheimer Disease; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Casein Kinases; Cattle; Cyclic AMP-Dependent Protein Kinases; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Humans; Immunoblotting; Kinetin; Microtubule-Associated Proteins; Microtubules; Neurons; Phosphorylation; Protein Kinases; Purines; Subcellular Fractions; tau Proteins | 2000 |
The relationship between differentiation and survival in PC12 cells treated with cyclic adenosine monophosphate in the presence of epidermal growth factor or nerve growth factor.
Topics: Animals; Cell Differentiation; Cell Survival; Colforsin; Cyclic AMP; Dibutyryl Cyclic GMP; Enzyme Inhibitors; Epidermal Growth Factor; Kinetin; Nerve Growth Factor; Neurons; PC12 Cells; Purines; Rats; Roscovitine | 2001 |
Inhibitory effect of pentalenolactone on vascular smooth muscle cell proliferation.
Topics: 3T3 Cells; Animals; Anti-Bacterial Agents; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cell Movement; Cells, Cultured; Cyclin-Dependent Kinases; DNA; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Glyceraldehyde-3-Phosphate Dehydrogenases; Glycolysis; Kinetin; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Purines; Rats; Rats, Sprague-Dawley; Receptors, Platelet-Derived Growth Factor; Sesquiterpenes; Time Factors; Tyrosine | 2001 |
Modulation of Sp1 activity by a cyclin A/CDK complex.
Topics: Animals; Binding Sites; CDC2 Protein Kinase; CDC2-CDC28 Kinases; Cell Cycle; Cell Line; Cyclin A; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; DNA; DNA-Binding Proteins; Gene Expression Regulation; Genes, Reporter; Histones; Humans; Kinetin; Phosphorylation; Precipitin Tests; Promoter Regions, Genetic; Protein Binding; Protein Kinases; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Purines; Response Elements; Sp1 Transcription Factor; Sp3 Transcription Factor; Transcription Factors; Zinc Fingers | 2001 |
Cell cycle in the fucus zygote parallels a somatic cell cycle but displays a unique translational regulation of cyclin-dependent kinases.
Topics: Animals; Antineoplastic Agents; CDC2 Protein Kinase; Cell Cycle; Cyclin-Dependent Kinases; Enzyme Inhibitors; Gene Expression Regulation, Plant; Genes, cdc; Histones; Kinetin; Mitosis; Molecular Sequence Data; Nocodazole; Peptide Fragments; Phaeophyceae; Phosphorylation; Protein Biosynthesis; Protein Kinases; Protein Processing, Post-Translational; Purines; Seeds; Tyrosine | 2001 |
Characterization of the Trypanosoma cruzi Cdc2p-related protein kinase 1 and identification of three novel associating cyclins.
Topics: Amino Acid Sequence; Animals; CDC2 Protein Kinase; CDC2-CDC28 Kinases; Cyclin-Dependent Kinases; Cyclins; Cytoplasm; Enzyme Inhibitors; Flavonoids; Histones; Immunoglobulin G; Immunohistochemistry; Kinetin; Mitochondria; Molecular Sequence Data; Piperidines; Precipitin Tests; Protein Kinases; Protozoan Proteins; Purines; Retinoblastoma Protein; Sequence Alignment; Trypanosoma cruzi | 2001 |
Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5.
Topics: Animals; Brain; Cocaine; Cocaine-Related Disorders; Corpus Striatum; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Dopamine; Dopamine and cAMP-Regulated Phosphoprotein 32; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Kinetin; Male; Mice; Mice, Transgenic; Nerve Tissue Proteins; Neurons; Oligonucleotide Array Sequence Analysis; Phosphoproteins; Phosphorylation; Proto-Oncogene Proteins c-fos; Psychomotor Performance; Purines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Roscovitine; Signal Transduction | 2001 |
Proteomics approach in classifying the biochemical basis of the anticancer activity of the new olomoucine-derived synthetic cyclin-dependent kinase inhibitor, bohemine.
Topics: Antineoplastic Agents; Cyclin-Dependent Kinases; Electrophoresis, Gel, Two-Dimensional; Enzyme Inhibitors; Humans; Kinetin; Neoplasm Proteins; Proteome; Purines; Tumor Cells, Cultured | 2000 |
CDK inhibitors suppress apoptosis induced by chemicals and by excessive expression of a cell death gene, reaper, in Drosophila cells.
Topics: 4-Butyrolactone; Animals; Apoptosis; Cells, Cultured; Cyclin-Dependent Kinases; Dose-Response Relationship, Drug; Drosophila melanogaster; Drosophila Proteins; Enzyme Inhibitors; Gene Expression Regulation; Kinetin; Peptides; Purines; Time Factors | 2000 |
Caspase-mediated Cdk2 activation is a critical step to execute transforming growth factor-beta1-induced apoptosis in human gastric cancer cells.
Topics: Annexin A5; Apoptosis; Blotting, Western; Bromodeoxyuridine; Caspase 3; Caspases; CDC2-CDC28 Kinases; Cell Cycle; Cell Cycle Proteins; Cell Division; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cyclins; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; In Situ Nick-End Labeling; Kinetin; Microtubule-Associated Proteins; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases; Purines; Retinoblastoma Protein; RNA, Messenger; Roscovitine; Stomach Neoplasms; Transforming Growth Factor beta; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2001 |
Cell death mediated by alloreactive cytotoxic T cells via the granule exocytosis or the Fas pathway is independent of p34cdc2 kinase: Fas dependent killing of cells arrested in the cell cycle.
Topics: Animals; Apoptosis; CDC28 Protein Kinase, S cerevisiae; Cell Cycle; Cell Separation; Cytotoxicity Tests, Immunologic; DNA Fragmentation; Enzyme Inhibitors; Exocytosis; fas Receptor; Flow Cytometry; Killer Cells, Natural; Kinetin; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Purines; T-Lymphocytes, Cytotoxic; Thapsigargin; Tumor Cells, Cultured | 2001 |
Structure-activity relationships and inhibitory effects of various purine derivatives on the in vitro growth of Plasmodium falciparum.
Topics: Adenine; Animals; Antimalarials; Cell Cycle; Dose-Response Relationship, Drug; Isopentenyladenosine; Kinetin; Parasitic Sensitivity Tests; Phosphotransferases; Plasmodium falciparum; Purines; Roscovitine; Structure-Activity Relationship | 2001 |
Mild cerebral ischemia induces loss of cyclin-dependent kinase inhibitors and activation of cell cycle machinery before delayed neuronal cell death.
Topics: Animals; Brain Ischemia; Bromodeoxyuridine; CDC2-CDC28 Kinases; Cell Cycle; Cell Cycle Proteins; Cell Death; Cell Hypoxia; Cells, Cultured; Cyclin D1; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Disease Models, Animal; Enzyme Inhibitors; Glucose; In Situ Nick-End Labeling; Kinetin; Mice; Mice, Inbred Strains; Microtubule-Associated Proteins; Neurons; Oxygen; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Purines; Rats; Rats, Wistar; Tumor Suppressor Proteins | 2001 |
Cell cycle-dependent control of polarised development by a cyclin-dependent kinase-like protein in the Fucus zygote.
Topics: Adenine; Algal Proteins; Aphidicolin; Cell Cycle; Cell Polarity; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; Enzyme Inhibitors; Kinetin; Microinjections; Phaeophyceae; Purines; Zygote | 2001 |
Phosphorylation of amyloid-beta at the serine 26 residue by human cdc2 kinase.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Animals; Antisense Elements (Genetics); Binding Sites; Brain; CDC2 Protein Kinase; Cells, Cultured; Cytotoxins; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Humans; Immunohistochemistry; Kinetin; Mice; Molecular Weight; Neural Networks, Computer; Neurons; Peptide Fragments; Pharmacokinetics; Phosphorylation; Protein Structure, Tertiary; Purines; Serine; Stem Cells | 2001 |
The late-domain-containing protein p6 is the predominant phosphoprotein of human immunodeficiency virus type 1 particles.
Topics: Cell Line; Cyclin-Dependent Kinases; Endopeptidases; Enzyme Inhibitors; gag Gene Products, Human Immunodeficiency Virus; Gene Products, gag; Genistein; HIV-1; Humans; Kinetin; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphoproteins; Phosphorylation; Protein Processing, Post-Translational; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Purines; Serine; Threonine; Tyrosine; Virion | 2002 |
Antiproliferative effect of plant cytokinin analogues with an inhibitory activity on cyclin-dependent kinases.
Topics: Apoptosis; CDC2 Protein Kinase; CDC2-CDC28 Kinases; Cell Cycle; Cell Division; Colony-Forming Units Assay; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Cytokinins; DNA, Neoplasm; Dose-Response Relationship, Drug; Enzyme Inhibitors; Kinetin; Leukemia; Plants; Protein Serine-Threonine Kinases; Purines; Time Factors; Tumor Cells, Cultured | 2002 |
Cdk5/p35 regulates neurotransmitter release through phosphorylation and downregulation of P/Q-type voltage-dependent calcium channel activity.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels, P-Type; Calcium Channels, Q-Type; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Down-Regulation; Electric Stimulation; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Exocytosis; Glutamic Acid; Hippocampus; In Vitro Techniques; Kinetin; Male; Nerve Tissue Proteins; Neurons; Neurotransmitter Agents; Phosphorylation; Protein Isoforms; Purines; Rats; Rats, Wistar; Roscovitine; Synaptosomes | 2002 |
Phosphorylation and functional regulation of ClC-2 chloride channels expressed in Xenopus oocytes by M cyclin-dependent protein kinase.
Topics: Animals; Chloride Channels; CLC-2 Chloride Channels; Cyclin-Dependent Kinases; Enzyme Inhibitors; Female; Kinetics; Kinetin; Marine Toxins; Mitosis; Okadaic Acid; Oocytes; Oxazoles; Phosphorylation; Purines; Recombinant Proteins; Xenopus | 2002 |
Two kinase activities are sufficient for sea urchin sperm chromatin decondensation in vitro.
Topics: Alkaloids; Animals; Benzophenanthridines; CDC2 Protein Kinase; Chromatin; Enzyme Stability; Histones; Kinetin; Male; Ovum; Phenanthridines; Phosphorylation; Protein Kinase C; Purines; Sea Urchins; Spermatozoa | 2002 |
Inhibition of mitochondrial permeability transition and release of cytochrome c by anti-apoptotic nucleoside analogues.
Topics: Adenine; Animals; Arabinofuranosylcytosine Triphosphate; Cytarabine; Cytochrome c Group; Drug Interactions; Enzyme Inhibitors; Ion Channels; Kinetin; Male; Mitochondria, Heart; Mitochondria, Liver; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Nucleic Acid Synthesis Inhibitors; Purines; Rats; Rats, Wistar | 2002 |
Synthetic inhibitors of CDKs induce different responses in androgen sensitive and androgen insensitive prostatic cancer cell lines.
Topics: Cell Division; Cyclin-Dependent Kinases; Enzyme Inhibitors; Humans; Kinetin; Male; Neoplasm Proteins; Neoplasms, Hormone-Dependent; Prostatic Neoplasms; Purines; Receptors, Androgen; Tumor Cells, Cultured | 2002 |
Association between the cell cycle and neural crest delamination through specific regulation of G1/S transition.
Topics: Animals; Antimetabolites; Bromodeoxyuridine; Cell Cycle; Cell Differentiation; Cell Movement; Cell Nucleus; Chick Embryo; Culture Techniques; DNA; Dose-Response Relationship, Drug; Enzyme Inhibitors; G1 Phase; Kinetin; Mimosine; Models, Biological; Morphogenesis; MyoD Protein; Neural Crest; Purines; Quail; S Phase; Transcription Factors; Tyrphostins | 2002 |
2,3,7,8-tetrachlorodibenzo-p-dioxin-dependent release from contact inhibition in WB-F344 cells: involvement of cyclin A.
Topics: Animals; Apoptosis; Carcinogens; Cell Line; Cyclin A; Cyclin D2; Cyclin-Dependent Kinases; Cyclins; Enzyme Inhibitors; In Vitro Techniques; Kinetin; Liver; Phosphorylation; Polychlorinated Dibenzodioxins; Purines; Rats; Rats, Inbred F344; Retinoblastoma Protein | 2002 |
Synthesis and biological activity of olomoucine II.
Topics: Antineoplastic Agents; CDC2 Protein Kinase; CDC28 Protein Kinase, S cerevisiae; Cell Survival; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Kinetin; Purines; Roscovitine; Structure-Activity Relationship; Tumor Cells, Cultured | 2002 |
Inducible DNA demethylation mediated by the maize Suppressor-mutator transposon-encoded TnpA protein.
Topics: 2,4-Dichlorophenoxyacetic Acid; Adenine; Aphidicolin; Benzyl Compounds; Bromodeoxyuridine; Cell Division; Culture Techniques; Dexamethasone; DNA Methylation; DNA Replication; DNA-Binding Proteins; DNA, Plant; Gene Expression Regulation; Kinetin; Naphthaleneacetic Acids; Nicotiana; Plant Proteins; Plants, Genetically Modified; Purines; Repressor Proteins; Suppression, Genetic; Transcriptional Activation; Zea mays | 2002 |
Studies of the cell cycle of in vitro cultured skin fibroblasts in goats: work in progress.
Topics: Animals; Apoptosis; Bromodeoxyuridine; Cell Cycle; Cells, Cultured; Culture Media, Serum-Free; Enzyme Inhibitors; Female; Fibroblasts; Flow Cytometry; Goats; Kinetin; Purines; Skin | 2003 |
The specificities of protein kinase inhibitors: an update.
Topics: Alkaloids; Anthracenes; Azepines; Benzazepines; Carbazoles; Catechin; Cyclin-Dependent Kinases; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Indoles; JNK Mitogen-Activated Protein Kinases; Kinetin; Mitogen-Activated Protein Kinases; Naphthalenes; Oximes; Protein Kinase Inhibitors; Purines; Pyrazoles; Pyrimidines; Signal Transduction; src-Family Kinases; Substrate Specificity | 2003 |
Comparison of the TUNEL, lamin B and annexin V methods for the detection of apoptosis by flow cytometry.
Topics: Annexin A5; Apoptosis; Dactinomycin; DNA Fragmentation; Enzyme Inhibitors; Etoposide; Flow Cytometry; Fluorescent Antibody Technique, Indirect; HL-60 Cells; Humans; In Situ Nick-End Labeling; Kinetin; Lamin Type B; Purines; Sensitivity and Specificity | 2002 |
Growth cones contain a dynamic population of neurofilament subunits.
Topics: Actins; Animals; Axons; Biological Transport; Cells, Cultured; Cytochalasin B; Dipeptides; Green Fluorescent Proteins; Growth Cones; Kinetin; Luminescent Proteins; Microtubules; Neurofilament Proteins; Nocodazole; Purines | 2003 |
Mixed ligand complexes of platinum(II) and palladium(II) with cytokinin-derived compounds Bohemine and Olomoucine: X-ray structure of [Pt(BohH+-N7)Cl(3)].9/5H2O [Boh=6-(benzylamino)-2-[(3-(hydroxypropyl)-amino]-9-isopropylpurine, Bohemine].
Topics: Antineoplastic Agents; Crystallography, X-Ray; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Kinetin; Ligands; Magnetic Resonance Spectroscopy; Models, Molecular; Organometallic Compounds; Organoplatinum Compounds; Palladium; Platinum; Purines; Structure-Activity Relationship; Tumor Cells, Cultured | 2003 |
Synthesis and biological evaluations of pyrazolo[3,4-d]pyrimidines as cyclin-dependent kinase 2 inhibitors.
Topics: Aniline Compounds; Animals; Antineoplastic Agents; Cell Division; Cell Line; Cyclin-Dependent Kinases; Enzyme Inhibitors; ErbB Receptors; Humans; Inhibitory Concentration 50; Kinetin; Magnetic Resonance Spectroscopy; Purines; Pyrazoles; Pyrimidines; Roscovitine; Spodoptera; Structure-Activity Relationship; Tumor Cells, Cultured | 2003 |
In vitro glycosidation potential towards olomoucine-type cyclin-dependent kinase inhibitors in rodent and primate microsomes.
Topics: Animals; Chromatography, Thin Layer; Cyclin-Dependent Kinases; Enzyme Inhibitors; Glycosides; Glycosylation; Humans; In Vitro Techniques; Kidney; Kinetin; Macaca mulatta; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Microsomes; Microsomes, Liver; Purines; Rats; Species Specificity | 2003 |
An inhibition of cyclin-dependent kinases that lengthens, but does not arrest, neuroepithelial cell cycle induces premature neurogenesis.
Topics: Animals; Cell Cycle; Cyclin-Dependent Kinases; Embryo, Mammalian; Enzyme Inhibitors; Female; G1 Phase; Gene Expression Regulation, Developmental; Genes, Tumor Suppressor; Immediate-Early Proteins; Kinetin; Mice; Neurons; Pregnancy; Purines; Tumor Suppressor Proteins | 2003 |
The expression of retinoblastoma and Sp1 is increased by low concentrations of cyclin-dependent kinase inhibitors.
Topics: Animals; Blotting, Western; Cell Division; Cell Nucleus; CHO Cells; Cloning, Molecular; Cricetinae; Cyclin-Dependent Kinases; Dose-Response Relationship, Drug; Flow Cytometry; HeLa Cells; Humans; Indoles; K562 Cells; Kinetin; Luciferases; Maleimides; Phosphorylation; Promoter Regions, Genetic; Protein Kinase C; Protein Synthesis Inhibitors; Purines; Retinoblastoma Protein; RNA, Messenger; Roscovitine; Sp1 Transcription Factor; Staurosporine; Tetrahydrofolate Dehydrogenase; Time Factors; Transcription, Genetic; Transfection | 2003 |
Angiostatin-induced inhibition of endothelial cell proliferation/apoptosis is associated with the down-regulation of cell cycle regulatory protein cdk5.
Topics: Angiogenesis Inhibitors; Angiostatins; Animals; Aorta; Apoptosis; Cattle; Cell Differentiation; Cell Division; Cells, Cultured; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Down-Regulation; Endothelial Cells; Fibroblast Growth Factors; Kinetin; Mice; NIH 3T3 Cells; Purines; Roscovitine | 2004 |
Nuclear translocation of the Hsp70/Hsp90 organizing protein mSTI1 is regulated by cell cycle kinases.
Topics: Active Transport, Cell Nucleus; Animals; Binding Sites; Casein Kinase II; CDC2 Protein Kinase; Cell Nucleus; Cytoplasm; Dichlororibofuranosylbenzimidazole; Fatty Acids, Unsaturated; G1 Phase; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Kinetin; Mice; NIH 3T3 Cells; Nuclear Localization Signals; Phosphoproteins; Phosphorylation; Protein Binding; Purines; Recombinant Fusion Proteins; S Phase | 2004 |
Development of an assay to screen for inhibitors of tau phosphorylation by cdk5.
Topics: Adenosine Triphosphate; Antibodies, Monoclonal; Binding Sites; Biotinylation; Cells, Cultured; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Humans; Kinetics; Kinetin; Miniaturization; Phosphorylation; Protein Binding; Purines; Recombinant Proteins; Substrate Specificity; tau Proteins; Time Factors | 2004 |
Cell differentiation, caspase inhibition, and macromolecular synthesis blockage, but not BCL-2 or BCL-XL proteins, protect SH-SY5Y cells from apoptosis triggered by two CDK inhibitory drugs.
Topics: Apoptosis; bcl-X Protein; Caspase Inhibitors; Cell Differentiation; Cell Line, Tumor; Cell Survival; Cyclin-Dependent Kinases; Enzyme Inhibitors; Humans; Kinetics; Kinetin; Neuroblastoma; Proto-Oncogene Proteins c-bcl-2; Purines; Roscovitine | 2004 |
Roscovitine, olomoucine, purvalanol: inducers of apoptosis in maturing cerebellar granule neurons.
Topics: 4-Butyrolactone; Animals; Apoptosis; CDC2 Protein Kinase; CDC2-CDC28 Kinases; Cerebellum; Cyclic AMP Response Element-Binding Protein; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinase 9; Cyclin-Dependent Kinases; Enzyme Inhibitors; JNK Mitogen-Activated Protein Kinases; Kinetin; Mitogen-Activated Protein Kinases; Neurons; Phosphorylation; Proto-Oncogene Proteins; Purines; Pyrimidines; Rats; Rats, Sprague-Dawley; Roscovitine; Signal Transduction; Sulfonamides | 2004 |
A novel CDK5-dependent pathway for regulating GSK3 activity and kinesin-driven motility in neurons.
Topics: Animals; Axonal Transport; Cell Movement; Cells, Cultured; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Decapodiformes; Enzyme Activation; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Growth Cones; Immunoblotting; Immunohistochemistry; Kinesins; Kinetics; Kinetin; Models, Biological; Neurites; Neurons; Okadaic Acid; Phosphorylation; Protein Binding; Purines; Rats; Recombinant Proteins; Substrate Specificity | 2004 |
Correlation between semaphorin3A-induced facilitation of axonal transport and local activation of a translation initiation factor eukaryotic translation initiation factor 4E.
Topics: Animals; Axonal Transport; Cells, Cultured; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Enzyme Inhibitors; Eukaryotic Initiation Factor-4E; Ganglia, Spinal; Growth Cones; Humans; Kinetin; Mice; Mice, Knockout; Nerve Tissue Proteins; Neurons; Phenols; Phosphorylation; Protein Biosynthesis; Protein Synthesis Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Purines; Semaphorin-3A; Signal Transduction; src-Family Kinases | 2004 |
Cyclin-dependent kinase inhibitors attenuate protein hyperphosphorylation, cytoskeletal lesion formation, and motor defects in Niemann-Pick Type C mice.
Topics: Animals; Apoptosis; Cyclin-Dependent Kinases; Cytoskeleton; Disease Models, Animal; Enzyme Inhibitors; Female; Humans; Intracellular Signaling Peptides and Proteins; Kinetin; Male; Mice; Mice, Inbred BALB C; Mice, Neurologic Mutants; Motor Activity; Nerve Degeneration; Neurons; Niemann-Pick C1 Protein; Niemann-Pick Diseases; Phosphorylation; Proteins; Purines; Purkinje Cells; Roscovitine; tau Proteins | 2004 |
Mitogen-activated protein kinase regulates neurofilament axonal transport.
Topics: Animals; Axonal Transport; Cell Line; Enzyme Inhibitors; Flavonoids; Imidazoles; Kinetin; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neurites; Neurofilament Proteins; Oligonucleotides, Antisense; Purines; Pyridines; Recombinant Fusion Proteins | 2004 |
Expression profiles of a human pancreatic cancer cell line upon induction of apoptosis search for modulators in cancer therapy.
Topics: Adenoviridae; Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Blotting, Western; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p16; Decorin; DNA Primase; DNA-Binding Proteins; Down-Regulation; Extracellular Matrix Proteins; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genes, p16; Genetic Vectors; Histone Deacetylase 1; Histone Deacetylases; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Kinetin; Nuclear Proteins; Pancreatic Neoplasms; Protein Kinase Inhibitors; Proteoglycans; Purines; Reverse Transcriptase Polymerase Chain Reaction; Roscovitine; Transcription Factors; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases; Up-Regulation; Von Hippel-Lindau Tumor Suppressor Protein | 2004 |
Synergic effects of the cyclin-dependent kinase (CDK) inhibitor olomoucine and androgen-antagonist bicalutamide on prostatic cancer cell lines.
Topics: Androgen Antagonists; Anilides; Cell Line, Tumor; Cell Survival; Cyclin-Dependent Kinases; Enzyme Inhibitors; Humans; Kinetin; Male; Nitriles; Prostatic Neoplasms; Purines; Tosyl Compounds | 2004 |
Cdk inhibition in human cells compromises chk1 function and activates a DNA damage response.
Topics: Ataxia Telangiectasia Mutated Proteins; CDC2 Protein Kinase; CDC2-CDC28 Kinases; Cell Cycle Proteins; Cell Line, Tumor; Checkpoint Kinase 1; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; DNA Damage; DNA-Binding Proteins; Down-Regulation; Enzyme Inhibitors; HeLa Cells; Histones; Humans; Kinetin; Protein Kinases; Protein Serine-Threonine Kinases; Purines; Roscovitine; Tumor Suppressor Proteins | 2005 |
Resveratrol-induced apoptotic death in human U251 glioma cells.
Topics: Amino Acid Chloromethyl Ketones; Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Caspase 3; Caspase 9; Caspase Inhibitors; Caspases; Cell Cycle; Cell Line, Tumor; Cytochromes c; Cytoplasm; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Glioma; Humans; Kinetin; L-Lactate Dehydrogenase; Phenols; Poly(ADP-ribose) Polymerases; Polyphenols; Proto-Oncogene Proteins c-bcl-2; Purines; Resveratrol; Signal Transduction; Stilbenes; Subcellular Fractions; Time Factors; Up-Regulation | 2005 |
Slowed N-type calcium channel (CaV2.2) deactivation by the cyclin-dependent kinase inhibitor roscovitine.
Topics: Action Potentials; Animals; Calcium; Calcium Channels, N-Type; Calcium Channels, P-Type; Calcium Channels, Q-Type; Computer Simulation; Cyclin-Dependent Kinases; Dose-Response Relationship, Drug; Electrophysiology; Enzyme Inhibitors; Ganglia, Sympathetic; Ion Channel Gating; Kinetics; Kinetin; Markov Chains; Membrane Potentials; Models, Chemical; Neurons; Neurotransmitter Agents; Protein Kinase Inhibitors; Protein Structure, Tertiary; Purines; Rana catesbeiana; Roscovitine | 2005 |
In vitro and in vivo pharmacokinetic-pharmacodynamic relationships for the trisubstituted aminopurine cyclin-dependent kinase inhibitors olomoucine, bohemine and CYC202.
Topics: Animals; Area Under Curve; Blotting, Western; CDC2 Protein Kinase; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinases; Enzyme Inhibitors; Female; HCT116 Cells; Humans; Inhibitory Concentration 50; Kinetin; Maximum Tolerated Dose; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms, Experimental; Phosphorylation; Purines; Recombinant Proteins; Retinoblastoma Protein; Roscovitine; Time Factors; Tissue Distribution; Xenograft Model Antitumor Assays | 2005 |
The role of protein kinase A and cyclin-dependent (CDC2) kinase in the control of basal and IGF-II-induced proliferation and secretory activity of chicken ovarian cells.
Topics: Animals; Carbazoles; Cell Growth Processes; Cyclic AMP-Dependent Protein Kinases; Cyclin-Dependent Kinase 2; Estradiol; Female; Granulosa Cells; Indoles; Insulin-Like Growth Factor II; Kinetin; Ovarian Follicle; Progesterone; Protein Kinase Inhibitors; Pyrroles; Testosterone; Theca Cells; Vasotocin | 2006 |
Role of the cell cycle in the pathobiology of central nervous system trauma.
Topics: Animals; Antineoplastic Agents; Astrocytes; Brain; Cell Cycle; Cell Proliferation; Cell Survival; Cells, Cultured; Central Nervous System; Dose-Response Relationship, Drug; Edema; Enzyme Inhibitors; Etoposide; Flavonoids; Kinetin; Magnetic Resonance Spectroscopy; Microglia; Mitosis; Neurons; Piperidines; Purines; Rats; Roscovitine; Up-Regulation | 2005 |
Molecular models of protein kinase 6 from Plasmodium falciparum.
Topics: Amino Acid Sequence; Animals; Binding Sites; Conserved Sequence; Cyclin-Dependent Kinases; Hydrogen Bonding; Kinetin; Mitogen-Activated Protein Kinases; Models, Molecular; Molecular Sequence Data; Plasmodium falciparum; Protein Kinase Inhibitors; Protein Structure, Tertiary; Protozoan Proteins; Purines; Roscovitine; Sequence Alignment; Static Electricity | 2005 |
DNA damage induces cdk2 protein levels and histone H2B phosphorylation in SH-SY5Y neuroblastoma cells.
Topics: Camptothecin; Caspase 3; Caspases; Cell Cycle; Cell Cycle Proteins; Cell Death; Cell Line, Tumor; Cyclin E; Cyclin-Dependent Kinase 2; DNA Damage; Enzyme Induction; Gene Expression Regulation; Genes, p53; Histones; Humans; In Vitro Techniques; Kinetin; Neuroblastoma; Neurons; Phosphorylation; Tumor Cells, Cultured | 2005 |
Cdk5-dependent regulation of glucose-stimulated insulin secretion.
Topics: Animals; Cell Line; Cyclin-Dependent Kinase 5; Glucose; Insulin; Insulin Secretion; Insulin-Secreting Cells; Kinetin; Mice; Nerve Tissue Proteins; Rats; Signal Transduction | 2005 |
Activation of CYP1A1 gene expression during primary culture of mouse hepatocytes.
Topics: Animals; Cells, Cultured; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Electrophoretic Mobility Shift Assay; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Genistein; Hepatocytes; Hydrogen Peroxide; Hydroquinones; Insulin; Isoflavones; Kinetin; Mice; Mice, Inbred C57BL; Okadaic Acid; Phosphorylation; Purines; RNA, Messenger; Roscovitine; Time Factors; Transcriptional Activation | 2005 |
Caspase 8/10 are not mediating apoptosis in neuroblastoma cells treated with CDK inhibitory drugs.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Caspase 10; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases; Cell Line, Tumor; Cyclin-Dependent Kinases; Enzyme Inhibitors; Humans; Jurkat Cells; Kinetin; Neuroblastoma; Purines; Roscovitine; Time Factors | 2005 |
Zinc(II) complexes with potent cyclin-dependent kinase inhibitors derived from 6-benzylaminopurine: synthesis, characterization, X-ray structures and biological activity.
Topics: Antineoplastic Agents; Benzyl Compounds; Cell Line, Tumor; Chlorides; Crystallography, X-Ray; Cyclin-Dependent Kinases; Differential Thermal Analysis; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Kinetin; Ligands; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Structure; Organometallic Compounds; Purines; Spectrophotometry, Infrared; Zinc Compounds | 2006 |
Cyclin dependent kinase inhibitors prevent apoptosis of postmitotic mouse motoneurons.
Topics: Animals; Apoptosis; Cell Survival; Cells, Cultured; Cyclin D1; Cyclin E; Cyclin-Dependent Kinases; Flavonoids; Kinetin; Mice; Mitosis; Motor Neurons; Nerve Growth Factors; Piperidines; Protein Kinase Inhibitors; Purines; Roscovitine | 2006 |
An efficient direct amination of cyclic amides and cyclic ureas.
Topics: Amides; Amidines; Amination; Catalysis; Guanidines; Kinetin; Molecular Structure; Urea | 2006 |
[Effects of cyclin dependent protein kinase inhibitor olomoucine on the microenvironment of axonal regeneration after spinal cord injury: an experiment with rats].
Topics: Animals; Axons; Blotting, Western; Cyclin-Dependent Kinases; Cyclins; Disease Models, Animal; Enzyme Inhibitors; Fluoroimmunoassay; GAP-43 Protein; Glial Fibrillary Acidic Protein; Kinetin; Nerve Regeneration; Proliferating Cell Nuclear Antigen; Random Allocation; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries | 2006 |
The effects of presynaptic calcium channel modulation by roscovitine on transmitter release at the adult frog neuromuscular junction.
Topics: 4-Aminopyridine; Amifampridine; Animals; Calcium Channels; Excitatory Postsynaptic Potentials; Kinetin; Neuromuscular Junction; Patch-Clamp Techniques; Potassium Channel Blockers; Presynaptic Terminals; Protein Kinase Inhibitors; Purines; Rana pipiens; Roscovitine; Synaptic Transmission; Xenopus laevis | 2006 |
Suppression of astroglial scar formation and enhanced axonal regeneration associated with functional recovery in a spinal cord injury rat model by the cell cycle inhibitor olomoucine.
Topics: Analysis of Variance; Animals; Astrocytes; Behavior, Animal; Blotting, Western; Cell Count; Cell Cycle Proteins; Cell Proliferation; Cicatrix; Disease Models, Animal; Enzyme Inhibitors; Female; Immunohistochemistry; In Situ Nick-End Labeling; Kinetin; Nerve Regeneration; Nerve Tissue Proteins; Rats; Rats, Sprague-Dawley; Recovery of Function; Spinal Cord Injuries; Time Factors; Up-Regulation | 2006 |
Development and validation of a liquid chromatography/tandem mass spectrometry method for the determination of the novel anticancer agent 17-DMAG in human plasma.
Topics: Antineoplastic Agents; Area Under Curve; Benzoquinones; Chromatography, High Pressure Liquid; Half-Life; Humans; Kinetin; Lactams, Macrocyclic; Pancreatic Neoplasms; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2006 |
p27 small interfering RNA induces cell death through elevating cell cycle activity in cultured cortical neurons: a proof-of-concept study.
Topics: Animals; Apoptosis; Cell Cycle; Cells, Cultured; Cerebral Cortex; Cyclin-Dependent Kinase Inhibitor p27; Kinetin; Neurons; Phosphorylation; Protein Kinase Inhibitors; Purines; Rats; Rats, Wistar; Retinoblastoma Protein; RNA Interference; RNA, Small Interfering | 2006 |
A purine analog kinase inhibitor, calcium/calmodulin-dependent protein kinase II inhibitor 59, reveals a role for calcium/calmodulin-dependent protein kinase II in insulin-stimulated glucose transport.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Biological Transport; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Glucose; Glucose Transporter Type 4; Green Fluorescent Proteins; Hypoglycemic Agents; Insulin; Kinetin; Mice; Protein Kinase Inhibitors; Purines; Retroviridae; Roscovitine; Transfection | 2007 |
Cell cycle inhibition attenuates microglia induced inflammatory response and alleviates neuronal cell death after spinal cord injury in rats.
Topics: Analysis of Variance; Animals; Brain Edema; CD11b Antigen; Cell Cycle; Cell Death; Cell Proliferation; Cytokines; Disease Models, Animal; DNA Fragmentation; Enzyme Inhibitors; Female; Immunohistochemistry; Ki-67 Antigen; Kinetin; Microglia; Neurons; Phosphopyruvate Hydratase; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries | 2007 |
Inhibiting cell cycle progression reduces reactive astrogliosis initiated by scratch injury in vitro and by cerebral ischemia in vivo.
Topics: Analysis of Variance; Animals; Astrocytes; Brain Injuries; Brain Ischemia; Cell Cycle; Cell Death; Cells, Cultured; Cyclin D1; Disease Models, Animal; Enzyme Inhibitors; Gliosis; Ki-67 Antigen; Kinetin; Male; Mice; Mice, Knockout; Middle Cerebral Artery; Rats; Rats, Wistar; Statistics, Nonparametric; Wounds and Injuries | 2007 |
Inhibition of Cdk5 in the nucleus accumbens enhances the locomotor-activating and incentive-motivational effects of cocaine.
Topics: Animals; Cocaine; Conditioning, Operant; Cyclin-Dependent Kinase 5; Dopamine; Dopamine Uptake Inhibitors; Enzyme Inhibitors; Kinetin; Male; Nucleus Accumbens; Purines; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Roscovitine; Signal Transduction | 2007 |
Attenuation of astrogliosis by suppressing of microglial proliferation with the cell cycle inhibitor olomoucine in rat spinal cord injury model.
Topics: Analysis of Variance; Animals; CD11b Antigen; Cell Proliferation; Disease Models, Animal; Enzyme Inhibitors; Female; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Gliosis; Ki-67 Antigen; Kinetin; Microglia; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spinal Cord Injuries; Time Factors | 2007 |
[Effects of cyclin dependent protein kinase inhibitor olomoucine on the neuronal apoptosis after status epilepticus: experiment with rats].
Topics: Animals; Apoptosis; Brain; Cyclin B; Cyclin B1; Cyclin-Dependent Kinases; Enzyme Inhibitors; Fluorescent Antibody Technique; In Situ Nick-End Labeling; Interleukin-1beta; Kinetin; Lithium Chloride; Male; Nerve Tissue Proteins; Neurons; Nuclear Proteins; Phosphopyruvate Hydratase; Pilocarpine; Random Allocation; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Status Epilepticus; Tumor Necrosis Factor-alpha | 2007 |
A new, unexpected action of olomoucine, a CDK inhibitor, on normal human cells: up-regulation of CLIMP-63, a cytoskeleton-linking membrane protein.
Topics: Animals; Breast Neoplasms; Cell Line, Transformed; Cell Line, Tumor; Cell Survival; Cyclin-Dependent Kinases; DNA; Dose-Response Relationship, Drug; Embryo, Mammalian; Enzyme Inhibitors; HL-60 Cells; Humans; Kinetin; Lung; Membrane Proteins; Mice; Purines; Roscovitine; Skin; Time Factors; Up-Regulation | 2007 |
Rat focal cerebral ischemia induced astrocyte proliferation and delayed neuronal death are attenuated by cyclin-dependent kinase inhibition.
Topics: Animals; Astrocytes; Brain Ischemia; Cell Death; Cell Proliferation; Disease Models, Animal; Drug Interactions; Enzyme Inhibitors; Glial Fibrillary Acidic Protein; In Situ Nick-End Labeling; Kinetin; Male; Neurons; Phosphopyruvate Hydratase; Rats; Rats, Wistar; Time Factors | 2008 |
The Cdk5 inhibitor olomoucine promotes corneal debridement wound closure in vivo.
Topics: Animals; Cadherins; Cells, Cultured; Cornea; Cyclin-Dependent Kinase 5; Debridement; Enzyme Inhibitors; Epithelial Cells; Humans; Kinetin; Limbus Corneae; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred Strains; Neutrophils; Time Factors; Tissue Distribution; Wound Healing | 2008 |
Involvement of septal Cdk5 in the emergence of excessive anxiety induced by stress.
Topics: Analysis of Variance; Animals; Anxiety; Behavior, Animal; Cyclin-Dependent Kinase 5; Disease Models, Animal; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Kinetin; Male; Maze Learning; Rats; Rats, Wistar; Septum of Brain; Stress, Psychological | 2008 |
Cell cycle-dependent regulation of extra-adrenal glucocorticoid synthesis in murine intestinal epithelial cells.
Topics: Animals; Aphidicolin; CDC2 Protein Kinase; Cell Cycle; Cell Differentiation; Cell Line; Cholesterol Side-Chain Cleavage Enzyme; Colforsin; Cyclin B; Cyclin B1; Cyclin D1; Doxorubicin; Glucocorticoids; Intestinal Mucosa; Kinetin; Mice; Nocodazole; Receptors, Cytoplasmic and Nuclear; Retinoblastoma Protein; Steroid 11-beta-Hydroxylase; Transfection | 2008 |
Pleiotropic effects of selective CDK inhibitors on human normal and cancer cells.
Topics: Cell Cycle; Cell Line; Cell Line, Tumor; Cyclin-Dependent Kinases; Humans; Kinetin; Phosphorylation; Protein Kinase Inhibitors; Purines; Roscovitine; Tumor Suppressor Protein p53 | 2008 |
Cellular phototoxicity evoked through the inhibition of human ABC transporter ABCG2 by cyclin-dependent kinase inhibitors in vitro.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Cell Line; Cell Membrane; Cell Survival; Chlorophyll; Cyclin-Dependent Kinases; Dose-Response Relationship, Drug; Hematoporphyrins; Humans; Kinetin; Models, Molecular; Molecular Conformation; Molecular Structure; Neoplasm Proteins; Photosensitizing Agents; Protein Kinase Inhibitors; Purines; Quantitative Structure-Activity Relationship; Quinazolines; Roscovitine; Spodoptera; Transfection | 2009 |
CDK5-dependent phosphorylation of the Rho family GTPase TC10(alpha) regulates insulin-stimulated GLUT4 translocation.
Topics: 3T3-L1 Cells; Actins; Animals; Cyclin-Dependent Kinase 5; Enzyme Inhibitors; Glucose Transporter Type 4; Insulin; Kinetin; Membrane Microdomains; Mice; Phosphorylation; Protein Transport; Proto-Oncogene Proteins c-fyn; rho GTP-Binding Proteins; RNA, Small Interfering | 2008 |
Cell cycle inhibitor enhances the resolution of HSV-1-induced proinflammatory response in murine microglial cells.
Topics: Animals; Animals, Newborn; Apoptosis; Cell Count; Cell Proliferation; Cells, Cultured; Chemokine CCL2; Cyclin D1; Cyclin-Dependent Kinases; Dose-Response Relationship, Drug; Encephalitis; Encephalitis, Herpes Simplex; Enzyme Inhibitors; Herpesvirus 1, Human; Kinetin; Mice; Mice, Inbred BALB C; Microglia; Myeloid Cell Leukemia Sequence 1 Protein; Proto-Oncogene Proteins c-bcl-2; Rabbits; Tumor Necrosis Factor-alpha | 2009 |
Inhibition of cyclin-dependent kinases by olomoucine and roscovitine reduces lipopolysaccharide-induced inflammatory responses via down-regulation of nuclear factor kappaB.
Topics: Animals; Cell Line, Tumor; Cyclin-Dependent Kinases; Down-Regulation; E2F1 Transcription Factor; Enzyme Inhibitors; Gene Expression; Inflammation; Interleukin-1alpha; Interleukin-6; Kinetin; Lipopolysaccharides; Macrophages; Mice; Models, Biological; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Promoter Regions, Genetic; Purines; RNA Interference; Roscovitine; Transcription Factor RelA; Tumor Necrosis Factor-alpha | 2009 |
Olomoucine inhibits cathepsin L nuclear translocation, activates autophagy and attenuates toxicity of 6-hydroxydopamine.
Topics: Analysis of Variance; Animals; Autophagy; Cathepsin L; Cathepsins; Cell Count; Cell Cycle; Cell Death; Cells, Cultured; Cyclin B; Cyclin D1; Cysteine Endopeptidases; Enzyme Inhibitors; Fluorescent Antibody Technique; Kinetin; Male; Microtubule-Associated Proteins; Neurons; Oxidopamine; Parkinson Disease, Secondary; Proliferating Cell Nuclear Antigen; Protein Transport; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Substantia Nigra; Time Factors; Tyrosine 3-Monooxygenase; Up-Regulation | 2009 |
Strong inhibition of replicative DNA synthesis in the developing rat cerebral cortex and glioma cells by roscovitine.
Topics: Age Factors; Animals; Animals, Newborn; Anticarcinogenic Agents; Cell Line, Tumor; Cerebral Cortex; DNA; DNA Damage; DNA Repair; Drug Screening Assays, Antitumor; Glioma; Humans; In Vitro Techniques; Kinetin; Nucleic Acid Synthesis Inhibitors; Protein Kinase Inhibitors; Purines; Rats; Rats, Sprague-Dawley; Roscovitine | 2010 |
Is olomoucine, a weak CDK2 inhibitor, able to induce apoptosis in cancer cells?
Topics: Apoptosis; Caspase 3; Caspase 7; Cell Cycle; Cyclin-Dependent Kinase 2; DNA, Neoplasm; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flow Cytometry; G1 Phase; G2 Phase; HeLa Cells; HL-60 Cells; Humans; Kinetin; Neoplasms; S Phase | 2009 |
Cdk5-dependent regulation of Rho activity, cytoskeletal contraction, and epithelial cell migration via suppression of Src and p190RhoGAP.
Topics: Cell Line; Cell Movement; Cyclin-Dependent Kinase 5; Cytoskeleton; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Guanine Nucleotide Exchange Factors; Humans; Kinetin; Myosin Light Chains; Recombinant Fusion Proteins; Repressor Proteins; rho GTP-Binding Proteins; rho-Associated Kinases; RNA, Small Interfering; Signal Transduction; src-Family Kinases | 2009 |
Roscovitine increases intracellular calcium release and capacitative calcium entry in PC12 cells.
Topics: Animals; Calcium; Calcium Signaling; Cell Differentiation; Cyclin-Dependent Kinase 5; Intracellular Space; Kinetin; Nerve Growth Factor; PC12 Cells; Purines; Rats; Roscovitine | 2010 |
Cytochalasin D, LY294002 and olomoucine synergize in promoting death of melanoma cells through activation of caspase-3 and apoptosis.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Caspase 3; Cell Growth Processes; Cell Line, Tumor; Cell Survival; Chromones; Cytochalasin D; Drug Synergism; Enzyme Activation; Humans; In Situ Nick-End Labeling; Kinetin; Melanoma; Morpholines; Skin Neoplasms; Staurosporine; Up-Regulation | 2010 |
The radiosensitising effect of olomoucine derived synthetic cyclin-dependent kinase inhibitors.
Topics: Adenocarcinoma; Apoptosis; Blotting, Western; Cell Cycle; Cyclin-Dependent Kinases; Flow Cytometry; Humans; Kinetin; Lung Neoplasms; Protein Kinase Inhibitors; Purines; Radiation-Sensitizing Agents; Roscovitine; Tumor Cells, Cultured; X-Rays | 2010 |
Functional inactivation of triosephosphate isomerase through phosphorylation during etoposide-induced apoptosis in HeLa cells: potential role of Cdk2.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cyclin A; Cyclin-Dependent Kinase 2; Dihydroxyacetone Phosphate; Etoposide; HeLa Cells; Humans; Kinetin; Phosphoproteins; Phosphorylation; Proteomics; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Triose-Phosphate Isomerase; Up-Regulation | 2010 |
Previous stress exposure enhances both anxiety-like behaviour and p35 levels in the basolateral amygdala complex: modulation by midazolam.
Topics: Amygdala; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Cell Count; Cyclin-Dependent Kinase 5; Enzyme Inhibitors; Immunohistochemistry; Interleukin-12 Subunit p35; Kinetin; Male; Midazolam; Rats; Rats, Wistar; Restraint, Physical; Stress, Psychological; Up-Regulation | 2010 |
Comparison of effects of protein kinase A, mitogen-activated protein kinase, and cyclin-dependent kinase blockers on rabbit ovarian granulosa cell functions.
Topics: Animals; Carbazoles; Cell Extracts; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cyclin-Dependent Kinases; Female; Flavonoids; Granulosa Cells; Insulin-Like Growth Factor I; Kinetin; Mitogen-Activated Protein Kinases; Proliferating Cell Nuclear Antigen; Protein Kinase Inhibitors; Pyrroles; Rabbits | 2010 |
Functional studies of MP62 during male chromatin decondensation in sea urchins.
Topics: Animals; Chromatin Assembly and Disassembly; Histones; Kinetin; Male; Nucleoplasmins; Protein Kinase Inhibitors; Purines; Roscovitine; Sea Urchins; Spermatozoa | 2013 |
Characterization of Plasmodium falciparum cdc2-related kinase and the effects of a CDK inhibitor on the parasites in erythrocytic schizogony.
Topics: Antimalarials; CDC2-CDC28 Kinases; Cells, Cultured; Cyclin-Dependent Kinases; Erythrocytes; Gene Expression Regulation, Enzymologic; Humans; Kinetin; Plasmodium falciparum | 2013 |
The effect of cyclin-dependent kinases inhibitor treatment on experimental herpes simplex encephalitis mice.
Topics: Animals; Apoptosis; Brain; Brain Edema; Cyclin-Dependent Kinases; Encephalitis, Herpes Simplex; Enzyme Inhibitors; Female; Herpesvirus 1, Human; Kaplan-Meier Estimate; Kinetin; Mice; Mice, Inbred BALB C; Microglia; Viral Envelope Proteins | 2016 |
Down-regulation of BNIP3 by olomoucine, a CDK inhibitor, reduces LPS- and NO-induced cell death in BV2 microglial cells.
Topics: Animals; Apoptosis; Cell Line; Cell Proliferation; Cyclin-Dependent Kinases; Down-Regulation; E2F Transcription Factors; Enzyme Inhibitors; Inflammation; Inflammation Mediators; Kinetin; Lipopolysaccharides; Membrane Proteins; Mice; Microglia; Mitochondria; Mitochondrial Proteins; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II | 2016 |
CDK5 inhibitors prevent astroglial apoptosis and reactive astrogliosis by regulating PKA and DRP1 phosphorylations in the rat hippocampus.
Topics: Animals; Apoptosis; Astrocytes; CA1 Region, Hippocampal; Cyclic AMP-Dependent Protein Kinases; Cyclin-Dependent Kinase 5; Dentate Gyrus; Dynamins; Gliosis; Kinetin; Male; Nerve Degeneration; Phosphorylation; Protein Kinase Inhibitors; Purines; Rats; Roscovitine; Status Epilepticus | 2017 |
Differential effects of the cell cycle inhibitor, olomoucine, on functional recovery and on responses of peri-infarct microglia and astrocytes following photothrombotic stroke in rats.
Topics: Animals; Astrocytes; Cell Cycle; Disease Models, Animal; Gliosis; Kinetin; Male; Microglia; Motor Cortex; Neurons; Rats; Rats, Sprague-Dawley; Recovery of Function; Stroke | 2021 |