kibdelomycin and amycolamicin

The complex and intriguing structures of the antibiotics amycolamicin and kibdelomycin are herein confirmed through total synthesis. Careful titration of the synthetic products reveals that kibdelomycin is the salt form of amycolamicin. This synthesis employs a highly convergent strategy, which provides a modular approach for further SAR studies of this class of antibiotics.

Topics: Anti-Bacterial Agents; Biological Products; Crystallography, X-Ray; Drug Resistance, Bacterial; Glucosides; Gram-Positive Bacteria; Molecular Conformation; Pyrroles; Pyrrolidinones