ketotifen and histamine

ketotifen has been researched along with histamine in 78 studies

Research

Studies (78)

Timeframe	Studies, this research(%)	All Research%
pre-1990	29 (37.18)	18.7374
1990's	19 (24.36)	18.2507
2000's	21 (26.92)	29.6817
2010's	9 (11.54)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
DeLeo, JJ; Handley, DA; Havill, AM	1
Nakaji, S; Okabe, S; Tachibana, M	1
Go, K; Hata, T; Namimatsu, A	1
Cockcroft, DW; Gore, BC; Keshmiri, M; Murdock, KY	1
Córdoba, H; Fernández, M; Oehling, A; Santos, F	1
Holgate, ST; Lai, CK; Lau, CK; Ollier, S	1
Nakagawa, T	1
Kanai, Y; Misawa, M	1
Besarab, A; Burke, JF; Francos, GC; Gittlen, SD; Goyal, S; Kauh, YC; Schulman, ES	1
Azuma, H; Ito, Y; Kato, H; Koda, A; Makino, E; Nagai, H; Ohashi, T; Takahashi, H	1
Graves, L; Lukert, BP; Morris, DC; Stechschulte, DJ	1
Chiang, BN; Wang, SR; Wang, SS	1
Baylor, MW; Bressler, RB; Huston, DP; Kaliner, M; Sowell, LK	1
Subramanian, N	1
Hoshino, K; Kawasaki, A; Mizushima, Y; Yano, S	1
Friedberg, KD; Sekardi, L	1
Greaves, MW; Mallet, AI; Norris, P; Rendell, NB; Wong, E	1
Shindoh, Y; Takishima, T; Tanno, Y	1
Arreaza, EE; Grant, JA; Lett-Brown, MA; McClean, SP	1
Berkebile, C; Bradley, D; Kettelhut, BV; Metcalfe, DD	1
Andriano, K; Mansfield, LE; Santamauro, J; Taistra, P; Ting, S	1
Cundell, DR; Davies, RJ; Moodley, I; Morgan, DJ; Sheinman, BD; Smart, W	1
Magnussen, H	1
Adamus, WS; Lohmann, H; Oldigs-Kerber, J	1
Corrado, OJ; Davies, RJ; Ollier, S; Phillips, MJ; Thomas, JM	1
Abe, H; Ito, K; Kawano, Y; Kuramochi, M; Omae, T; Saitoh, F; Yoshida, K	1
Barja, S; Cruz, E; Ferretti, R; Lisboa, C; Moran, J; Moreno, R; Sanchez, I	1
Colas Sanz, C; de Barrio Fernandez, M; Gozalo Reques, F; Herrero Lopez, T; Rubio Sotes, M; Senent Sanchez, C	1
Goto, S; Inagaki, N; Koda, A; Nagai, H; Yamada, H	1
Forche, G; Zenker, G	1
Costello, JF; Heaton, R; Loftus, BG; Price, JF	1
Ottenhof, M; Ufkes, JG; Van Rooij, HH	1
Svedmyr, N	1
Fukuda, T; Iemura, R; Ito, K; Kawashima, T; Morimoto, Y; Tsukamoto, G	1
Mikuni, I	1
Davies, RJ; Moodley, I	1
Górski, P; Grzelewska-Rzymowska, I; Rozniecki, J; Szmidt, M	1
Davies, RJ; Gould, C; Ollier, S; Phillips, MJ	1
del Carpio, J; Esau, S; Martin, JG	1
Armour, C; Temple, DM	1
Inagaki, N; Kawasaki, H; Nagai, H; Takaoka, Y; Takeda, H	1
Kamei, C; Nakamura, S; Tasaka, K	1
Hoshino, K; Kawasaki, A; Kobayashi, M; Mizushima, Y; Oosaki, R; Yano, S	1
Hanai, N; Kusano, A; Masaki, S; Miki, I; Ohmori, K; Ohta, S; Otoshi, M; Sato, S	1
Brady, MT; Gamache, DA; Graff, G; Lang, LS; Miller, ST; Parnell, D; Spellman, JM; Stephens, DJ; Weimer, LK; Yanni, JM	1
Akimoto, S; Amano, H; Hashimoto, T; Kanbe, N; Kurimoto, F; Kurosawa, M; Miyachi, Y; Takeuchi, Y; Yamashita, T	1
Aritake, K; Hayashi, K; Hayashi, M; Hirotsu, I; Hizue, M; Kimura, Y; Matsushita, N; Mitsui, K; Nakajima, H; Takada, A; Tani, T	1
Eklund-Uusitalo, S; Eriksson, L; Fogel, WA; Maslinski, C; Tuomisto, L	1
Hung, CR	2
Abe, M; Igarashi, Y; Ishikawa, O; Kurosawa, M; Miyachi, Y	1
Inagaki, N; Kanke, T; Matsumoto, J; Nagai, H; Nagao, M; Takizawa, T; Timmerman, H; Tohma, T; Wada, Y; Zhang, MQ	1
Ando, N; Endoh, T; Honda, T; Kamei, J; Kawamura, K; Nagase, H; Okano, K; Tanaka, T; Togashi, Y; Umeuchi, H; Utsumi, J; Yoshizawa, Y	1
Fang, YI; Hashimoto, T; Momose, K; Nakano, Y; Ohata, H; Yamashita, M	1
Bueno, L; Fioramonti, J; Garcia-Villar, R; Gay, J; Ressayre, L	1
Coll, RC; Fogal, TH; Penissi, AB; Piezzi, RS; Rudolph, MI; Villar, M	1
Dugina, TN; Glusa, E; Kiseleva, EV; Strukova, SM	1
Becker, BF; Gilles, S; Sommerhoff, CP; Welsch, U; Zahler, S	1
Hashimoto, T; Hoshina, F; Igarashi, A; Kohno, S; Notsu, Y; Toyoda, Y; Yamada, M	1
Hung, CR; Wang, PS	1
Aikawa, T; Inoue, Y; Matsumoto, I; Shimada, T; Tsuchiya, K	1
Fujii, Y; Jiang, S; Kamei, C; Takubo, M; Tsumuro, T	1
Alejandra Hossen, M; Fujii, Y; Kamei, C; Kishi, Y; Tsumuro, T	1
Hiyama, Y; Ishimura, M; Kataoka, S; Maeda, T; Suda, M	1
Kimura, S; Kino, K; Kozutsumi, D; Murakami, R; Tsunematsu, M; Yamaji, T	1
Beauregard, C; Gamache, D; Roberts, L; Stephens, D; Yanni, J	1
Ding, Y; Han, D; Li, R; Li, W; She, R; Sun, Q; Wang, D; Yue, Z	1
Bonini, S; Lambiase, A; Micera, A	1
Imai, Y; Kaida, S; Kawanishi, M; Ohashi, K; Ohta, Y	1
Asano, K; Furuta, A; Hirano, K; Shoji, N; Suzaki, H	1
Acharya, N; Acharya, S; Jasani, N; Kapoor, M; Kumar, V	1
Fujii, M; Kijitani, Y; Kitagawa, Y; Nabe, T; Nakao, S; Sakai, M; Sakano, E; Takai, S; Ueno, T	1
Jimenez-Gomez, C; Podlesnik, CA	1
Gan, XL; Hei, ZQ; Huang, PJ; Liu, DZ; Liu, JP; Wang, YL	1
Deng, Z; Huang, Q; Jauhiainen, M; Li, J; Libby, P; Liu, J; Metso, J; Shi, GP; Wang, X; Yan, X; Zhang, X	1
Chen, Q; Lu, Z; Miao, X; Wei, K; Wu, X; Yu, D; Zhu, J; Zhu, M	1

Reviews

3 review(s) available for ketotifen and histamine

Article	Year
Eye itching in ophthalmology and its treatment. The Tokai journal of experimental and clinical medicine, 1984, Volume: 9, Issue:5-6 Topics: Conjunctiva; Cromolyn Sodium; Dermatitis; Eczema; Edema; Emotions; Eye; Histamine; Histamine H1 Antagonists; Hot Temperature; Humans; Hypersensitivity; Ketotifen; Phosphotransferases; Pruritus; Rhinitis, Allergic, Seasonal; Skin; Steroids; Sympathomimetics; Urticaria; Vasodilation; Xanthenes	1984
Antiallergic compounds. Pharmacology & therapeutics, 1982, Volume: 17, Issue:3 Topics: Adrenal Cortex Hormones; Allergens; Animals; Aspirin; Bronchodilator Agents; Cromolyn Sodium; Histamine; Histamine Release; Humans; Hypersensitivity; Ketotifen; Oxamic Acid; Physical Exertion; Piperazines; Species Specificity; Sulfur Dioxide	1982
Multiple action agents and the eye: do they really stabilize mast cells? Current opinion in allergy and clinical immunology, 2009, Volume: 9, Issue:5 Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acid; Conjunctivitis, Allergic; Cytokines; Dibenzazepines; Dibenzoxepins; Histamine; Histamine Antagonists; Humans; Imidazoles; Immunity, Innate; Ketotifen; Mast Cells; Olopatadine Hydrochloride; Phthalazines	2009

Trials

11 trial(s) available for ketotifen and histamine

Article	Year
Allergen-induced increase in airway responsiveness is not inhibited by acute treatment with ketotifen or clemastine. Annals of allergy, 1992, Volume: 68, Issue:3 Topics: Adult; Airway Resistance; Allergens; Analysis of Variance; Asthma; Clemastine; Cromolyn Sodium; Dose-Response Relationship, Drug; Female; Histamine; Humans; Ketotifen; Male; Skin Tests	1992
Effect of azelastine and ketotifen on the bronchial and skin responses to platelet-activating factor in humans. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 1991, Volume: 21, Issue:4 Topics: Adult; Bronchoconstriction; Female; Forced Expiratory Volume; Histamine; Histamine H1 Antagonists; Humans; Ketotifen; Male; Middle Aged; Phthalazines; Platelet Activating Factor; Skin	1991
Suppressive effects of oral ketotifen on skin responses to histamine, codeine, and allergen skin tests. Annals of allergy, 1985, Volume: 55, Issue:1 Topics: Administration, Oral; Adult; Allergens; Codeine; Dose-Response Relationship, Immunologic; Erythema; Female; Histamine; Histamine Release; Humans; Hypersensitivity, Immediate; Intradermal Tests; Ketotifen; Male; Skin Tests	1985
A double-blind, placebo-controlled, crossover trial of ketotifen versus hydroxyzine in the treatment of pediatric mastocytosis. The Journal of allergy and clinical immunology, 1989, Volume: 83, Issue:5 Topics: Child; Child, Preschool; Clinical Trials as Topic; Double-Blind Method; Female; Histamine; Humans; Hydroxyzine; Infant; Ketotifen; Male; Mastocytosis	1989
Circulating histamine and neutrophil chemotactic activity during allergen-induced asthma: the effect of inhaled antihistamines and anti-allergic compounds. Clinical science (London, England : 1979), 1985, Volume: 69, Issue:1 Topics: Adult; Allergens; Asthma; Bronchial Provocation Tests; Chemotaxis, Leukocyte; Clemastine; Cromolyn Sodium; Drug Evaluation; Female; Forced Expiratory Volume; Histamine; Histamine H1 Antagonists; Humans; Hypersensitivity, Immediate; Ketotifen; Male; Middle Aged; Neutrophils; Time Factors	1985
The inhibitory effect of azelastine and ketotifen on histamine-induced bronchoconstriction in asthmatic patients. Chest, 1987, Volume: 91, Issue:6 Topics: Adult; Asthma; Bronchial Provocation Tests; Double-Blind Method; Female; Histamine; Histamine H1 Antagonists; Humans; Ketotifen; Male; Phthalazines; Pyridazines; Random Allocation	1987
Pharmacodynamics of the new H1-antagonist 3-amino-9,13b-dihydro-1H-dibenz[c,f]imidazo[1,5-a]azepine hydrochloride in volunteers. Arzneimittel-Forschung, 1987, Volume: 37, Issue:5 Topics: Adult; Azepines; Dibenzazepines; Double-Blind Method; Emotions; Flicker Fusion; Histamine; Histamine H1 Antagonists; Humans; Imidazoles; Ketotifen; Male; Psychomotor Performance; Reaction Time; Skin Tests	1987
Histamine and allergen induced changes in nasal airways resistance measured by anterior rhinomanometry: reproducibility of the technique and the effect of topically administered antihistaminic and anti-allergic drugs. British journal of clinical pharmacology, 1987, Volume: 24, Issue:3 Topics: Administration, Topical; Adult; Airway Resistance; Allergens; Clemastine; Cromolyn Sodium; Dose-Response Relationship, Drug; Female; Histamine; Histamine Antagonists; Humans; Ketotifen; Male; Middle Aged; Nose	1987
Acute effect of ketotifen on the dose-response curve of histamine and methacholine in asthma. British journal of diseases of the chest, 1985, Volume: 79, Issue:3 Topics: Adolescent; Adult; Aged; Asthma; Bronchi; Bronchial Provocation Tests; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Histamine; Humans; Ketotifen; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged	1985
Long-term modification on histamine-induced bronchoconstriction by disodium cromoglycate and ketotifen versus placebo. Allergy, 1985, Volume: 40, Issue:4 Topics: Adolescent; Adult; Asthma; Bronchi; Cromolyn Sodium; Female; Forced Expiratory Volume; Histamine; Humans; Ketotifen; Male; Middle Aged; Time Factors	1985
A comparison of the effects of ketotifen and clemastine on cutaneous and airway reactivity to histamine and allergen in atopic asthmatic subjects. The Journal of allergy and clinical immunology, 1984, Volume: 74, Issue:3 Pt 1 Topics: Adult; Airway Resistance; Allergens; Bronchial Provocation Tests; Clemastine; Female; Histamine; Humans; Hypersensitivity, Immediate; Ketotifen; Male; Middle Aged; Pyrrolidines; Respiratory Function Tests; Skin	1984

Other Studies

64 other study(ies) available for ketotifen and histamine

Article	Year
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Induction by aerosol allergen of sustained and nonspecific IgE-mediated airway hyperreactivity in the guinea pig. Agents and actions, 1992, Volume: 37, Issue:3-4 Topics: Acetylcholine; Aerosols; Allergens; Animals; Asthma; Bronchial Hyperreactivity; Diphenhydramine; Guinea Pigs; Histamine; Hormone Antagonists; Immunoglobulin E; Ketotifen; Organic Chemicals; Ovalbumin; Platelet Membrane Glycoproteins; Prednisolone; Pulmonary Eosinophilia; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Theophylline	1992
Effect of ketotifen on acute gastric lesions and gastric secretion in rats. Japanese journal of pharmacology, 1992, Volume: 59, Issue:2 Topics: Animals; Aspirin; Ethanol; Gastric Acid; Gastric Mucosa; Histamine; Ketotifen; Male; p-Methoxy-N-methylphenethylamine; Rats; Rats, Sprague-Dawley	1992
Regulatory effect of neurotropin on nasal mucosal hypersensitivity in guinea pigs caused by SART (intermittent exposure to cold) stress. Japanese journal of pharmacology, 1992, Volume: 59, Issue:3 Topics: Analgesics; Animals; Cold Temperature; Dose-Response Relationship, Drug; Guinea Pigs; Histamine; Ketotifen; Male; Methacholine Chloride; Nasal Mucosa; Polysaccharides; Radioligand Assay; Respiratory Hypersensitivity; Stress, Physiological	1992
In vitro ketotifen protection in bronchial hyperreactivity. Journal of investigational allergology & clinical immunology, 1991, Volume: 1, Issue:6 Topics: Adolescent; Adult; Animals; Asthma, Exercise-Induced; Basophil Degranulation Test; Basophils; Bronchial Hyperreactivity; Child; Exercise; Female; Histamine; Humans; In Vitro Techniques; Ketotifen; Leukocyte Count; Male; Mites; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal	1991
[Chemical mediators and anti-mediator drugs]. Kokyu to junkan. Respiration & circulation, 1991, Volume: 39, Issue:6 Topics: Asthma; Chemotactic Factors, Eosinophil; Cromolyn Sodium; Cytokines; Depression, Chemical; Histamine; Humans; Hypersensitivity; Ketotifen; Mast Cells; ortho-Aminobenzoates; Phthalazines; SRS-A	1991
Effect of the new antiallergic drug epinastine on chemical mediator induced bronchoconstrictions in guinea pigs. Arzneimittel-Forschung, 1991, Volume: 41, Issue:11 Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Bradykinin; Bronchoconstriction; Dibenzazepines; Guinea Pigs; Histamine; Histamine H1 Antagonists; Imidazoles; Ketotifen; Male; Neurokinin A; Phthalazines; Piperazines; Prostaglandin D2; Prostaglandin Endoperoxides, Synthetic; SRS-A; Substance P	1991
Elevated plasma histamine in chronic uremia. Effects of ketotifen on pruritus. International journal of dermatology, 1991, Volume: 30, Issue:12 Topics: Chronic Disease; Histamine; Humans; Ketotifen; Mast Cells; Pilot Projects; Pruritus; Renal Dialysis; Uremia	1991
Inhibitory effect of HSR-6071, a new anti-allergic agent, on experimental asthma in rats and guinea-pigs. The Journal of pharmacy and pharmacology, 1990, Volume: 42, Issue:4 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aminopyridines; Animals; Asthma; Azoles; Bronchi; Cromolyn Sodium; Female; Guinea Pigs; Histamine; Hypersensitivity; Immunoglobulin E; In Vitro Techniques; Ketotifen; Lung; Male; Muscle Relaxation; Muscle, Smooth; Passive Cutaneous Anaphylaxis; Pyrrolidines; Rabbits; Rats; Rats, Inbred Strains; SRS-A; Tetrazoles	1990
Inhibition of mediator release in systemic mastocytosis is associated with reversal of bone changes. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1990, Volume: 5, Issue:11 Topics: Bone and Bones; Bone Resorption; Calcitriol; Histamine; Humans; Ketotifen; Male; Mast Cells; Mastocytosis; Middle Aged; Osteocalcin	1990
Prevention of mast-cell degranulation by ketotifen in patients with physical urticarias. Annals of internal medicine, 1986, Volume: 104, Issue:4 Topics: Adult; Cold Temperature; Cytoplasmic Granules; Female; Histamine; Histamine Release; Humans; Ketotifen; Mast Cells; Middle Aged; Physical Exertion; Physical Stimulation; Urticaria	1986
Inhibition of immunological and non-immunological histamine release from human basophils and lung mast cells by formoterol. Arzneimittel-Forschung, 1986, Volume: 36, Issue:3 Topics: Albuterol; Basophils; Dose-Response Relationship, Drug; Ethanolamines; Fenoterol; Formoterol Fumarate; Histamine; Histamine Antagonists; Histamine Release; Humans; Isoproterenol; Ketotifen; Lung; Mast Cells	1986
[Improvement of airway hyperreactivity in bronchial asthma patients with short disease duration treated with anti-allergic agents]. Arerugi = [Allergy], 1989, Volume: 38, Issue:5 Topics: Adult; Asthma; Bronchi; Cromolyn Sodium; Drug Therapy, Combination; Female; Histamine; Humans; Ketotifen; Male; Middle Aged; ortho-Aminobenzoates; Phthalazines; Time Factors	1989
Inhibition of immunological histamine release from guinea pig lungs and other organs by mepyramine, ketotifen, and picumast in vivo. Arzneimittel-Forschung, 1989, Volume: 39, Issue:10A Topics: Aminopyridines; Anaphylaxis; Animals; Coumarins; Female; Guinea Pigs; Histamine; Histamine H1 Antagonists; Histamine Release; Ketotifen; Lung; Male; Pyrilamine	1989
The effect of disodium cromoglycate and ketotifen on the excretion of histamine and N tau-methylimidazole acetic acid in urine of patients with mastocytosis. British journal of clinical pharmacology, 1989, Volume: 27, Issue:1 Topics: Adult; Cromolyn Sodium; Female; Histamine; Humans; Imidazoles; Ketotifen; Male; Mastocytosis; Middle Aged	1989
Modulation of human basophil growth in vitro by xiao-qing-long-tang (syo-seiryu-to), chai-pu-tang (saiboku-to), qing-fei-tang (seihai-to), baicalein and ketotifen. The American journal of Chinese medicine, 1989, Volume: 17, Issue:1-2 Topics: Basophils; Dose-Response Relationship, Drug; Drug Interactions; Drugs, Chinese Herbal; Flavanones; Flavonoids; Histamine; Histamine H1 Antagonists; Humans; Ketotifen; Leukotriene B4; SRS-A	1989
Refractory cholinergic urticaria successfully treated with ketotifen. The Journal of allergy and clinical immunology, 1989, Volume: 83, Issue:4 Topics: Adolescent; Adult; Child; Cold Temperature; Exercise; Female; Histamine; Hot Temperature; Humans; Ketotifen; Male; Peptide Hydrolases; Urticaria	1989
Inhibition of dermographia, histamine, and dextromethorphan skin tests by ketotifen. A possible effect on cutaneous vascular response to mediators. Annals of allergy, 1989, Volume: 63, Issue:3 Topics: Adult; Chlorpheniramine; Cimetidine; Dextromethorphan; Drug Administration Schedule; Drug Combinations; Female; Histamine; Humans; Ketotifen; Levorphanol; Male; Middle Aged; Pressure; Skin; Skin Tests	1989
[A case of systemic mastocytosis with flushing, palpitation and dyspnea]. Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1987, Volume: 76, Issue:12 Topics: Chlorpheniramine; Cimetidine; Diagnosis, Differential; Drug Therapy, Combination; Dyspnea; Histamine; Humans; Ketotifen; Male; Mastocytosis; Middle Aged; Skin	1987
Reduction of antigen-induced contraction of sensitized guinea-pig tracheal smooth muscle in vitro by calmodulin inhibitors. International archives of allergy and applied immunology, 1985, Volume: 76, Issue:3 Topics: Animals; Antigens; Calmodulin; Chlorpromazine; Female; Guinea Pigs; Histamine; Imidazoles; Immunization; Ketotifen; Male; Muscle Contraction; Muscle, Smooth; SRS-A; Trachea	1985
Influence of drug therapy on bronchial hyperreactivity. International journal of clinical pharmacology, therapy, and toxicology, 1985, Volume: 23, Issue:6 Topics: Adult; Blood Pressure; Bronchial Diseases; Bronchial Provocation Tests; Female; Heart Rate; Histamine; Humans; Ketotifen; Lung Diseases, Obstructive; Male; Middle Aged; Respiration	1985
Effects of ketotifen on in vitro bronchoconstriction. Clinical allergy, 1985, Volume: 15, Issue:5 Topics: Acetylcholine; Animals; Antigens; Bronchi; Guinea Pigs; Histamine; Humans; Hypersensitivity; Ketotifen; Male; Muscle Contraction; Muscle, Smooth; Ovalbumin; Trachea	1985
The effect of prednisolone and ketotifen on the antigen-induced bronchoconstriction and mediator release in rat isolated lungs. British journal of pharmacology, 1985, Volume: 86, Issue:3 Topics: Anaphylaxis; Animals; Bronchi; Female; Histamine; In Vitro Techniques; Ketotifen; Lung; Muscle Contraction; Prednisolone; Rats; Rats, Inbred BN; Serotonin; Serum Albumin, Bovine; SRS-A	1985
Airway hyperreactivity. Clinical treatment with drugs. European journal of respiratory diseases. Supplement, 1983, Volume: 131 Topics: Acetylcholine; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Asthma; Bronchial Provocation Tests; Cromolyn Sodium; Gold; Histamine; Humans; Ketotifen; Respiratory Hypersensitivity; Terbutaline	1983
Effect of 1-(2-ethoxyethyl)-2-(4-methyl-1-homopiperazinyl)-benzimida zole difumarate (KB-2413), a new antiallergic, on chemical mediators. Arzneimittel-Forschung, 1984, Volume: 34, Issue:7 Topics: Acetylcholine; Airway Resistance; Animals; Benzimidazoles; Bradykinin; Capillary Permeability; Guinea Pigs; Histamine; Histamine H1 Antagonists; Ileum; In Vitro Techniques; Ketotifen; Muscle Contraction; Muscle, Smooth; Neurotransmitter Agents; Parasympatholytics; Serotonin Antagonists; Trachea	1984
[Comparative evaluation of the effectiveness of sodium cromoglycate and ketotifen in bronchial asthma and their effect on blood histamine and polymyxin-induced bronchial spasm]. Pneumonologia polska, 1983, Volume: 51, Issue:11 Topics: Asthma; Bronchial Spasm; Cromolyn Sodium; Female; Histamine; Humans; Ketotifen; Male; Polymyxin B	1983
Effect of antihistamines and antiallergic drugs on responses to allergen and histamine provocation tests in asthma. Thorax, 1984, Volume: 39, Issue:5 Topics: Adult; Allergens; Asthma; Bronchi; Bronchial Provocation Tests; Clemastine; Cromolyn Sodium; Double-Blind Method; Female; Forced Expiratory Volume; Histamine; Humans; Ketotifen; Male; Middle Aged; Pyrrolidines; Random Allocation	1984
The modification by ketotifen of respiratory responses to histamine and antigen in guinea-pigs. Agents and actions, 1982, Volume: 12, Issue:3 Topics: Aerosols; Airway Resistance; Anesthesia; Animals; Antigens; Cromolyn Sodium; Guinea Pigs; Histamine; Ketotifen; Pyrilamine; Respiration	1982
The effect of a TXA2 receptor antagonist ON-579 on experimental allergic reactions. Prostaglandins, leukotrienes, and essential fatty acids, 1995, Volume: 53, Issue:2 Topics: Aerosols; Airway Resistance; Animals; Antigens; Arthus Reaction; Bronchoalveolar Lavage Fluid; Concanavalin A; Dinitrophenols; Guinea Pigs; Histamine; Hypersensitivity; Ketotifen; Leukocyte Count; Male; Mice; Ovalbumin; Passive Cutaneous Anaphylaxis; Phenoxyacetates; Rats; Receptors, Thromboxane; Respiratory Tract Diseases; Serum Albumin, Bovine; Skin Diseases; Sulfonamides	1995
Effects of antiallergic agents including levocabastine on experimental rhinitis in rats. Arzneimittel-Forschung, 1994, Volume: 44, Issue:3 Topics: Acetylcholine; Animals; Antigens, Helminth; Ascaris; Histamine; Histamine H1 Antagonists; Ketotifen; Male; Nasal Mucosa; Piperidines; Platelet Activating Factor; Rats; Rats, Wistar; Rhinitis; Substance P	1994
Comparison of the effects on bronchial hyperresponsiveness of antiallergic agents and beclomethasone dipropionate in long-term bronchial asthma. A retrospective study. Allergy, 1993, Volume: 48, Issue:3 Topics: Adolescent; Adult; Aged; Asthma; Beclomethasone; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cromolyn Sodium; Female; Forced Expiratory Volume; Histamine; Humans; Immunoglobulin E; Ketotifen; Male; Middle Aged; Pyridines; Retrospective Studies; Vasodilator Agents; Vital Capacity	1993
Histamine enhanced the TNF-alpha-induced expression of E-selectin and ICAM-1 on vascular endothelial cells. Cellular immunology, 1996, Aug-01, Volume: 171, Issue:2 Topics: Animals; Cells, Cultured; CHO Cells; Cricetinae; Dibenzoxepins; Diphenhydramine; Drug Interactions; E-Selectin; Endothelium, Vascular; Histamine; Histamine H1 Antagonists; Histamine H2 Antagonists; Humans; Intercellular Adhesion Molecule-1; Ketotifen; Olopatadine Hydrochloride; Pyrilamine; Ranitidine; Tumor Necrosis Factor-alpha; Umbilical Veins	1996
The in vitro and in vivo ocular pharmacology of olopatadine (AL-4943A), an effective anti-allergic/antihistaminic agent. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 1996,Winter, Volume: 12, Issue:4 Topics: Administration, Topical; Anaphylaxis; Animals; Anti-Allergic Agents; Capillary Permeability; Conjunctiva; Conjunctivitis, Allergic; Dibenzoxepins; Dose-Response Relationship, Drug; Guinea Pigs; Histamine; Histamine H1 Antagonists; Histamine Release; Humans; Ketotifen; Male; Mast Cells; Olopatadine Hydrochloride; Ophthalmic Solutions; Rats; Rats, Sprague-Dawley	1996
Heterogeneity of mast cells in mastocytosis and inhibitory effect of ketotifen and ranitidine on indolent systemic mastocytosis. The Journal of allergy and clinical immunology, 1997, Volume: 100, Issue:6 Pt 2 Topics: Adult; Biopsy; Chymases; Dinoprostone; Histamine; Humans; Infant; Ketotifen; Leukotrienes; Male; Mast Cells; Mastocytosis; Ranitidine; Serine Endopeptidases; Thromboxane B2; Tryptases; Urticaria Pigmentosa	1997
Pharmacological studies on the novel antiallergic drug HQL-79: II. Elucidation of mechanisms for antiallergic and antiasthmatic effects. Japanese journal of pharmacology, 1998, Volume: 78, Issue:1 Topics: Animals; Anti-Allergic Agents; Anti-Asthmatic Agents; Antigens; Capillary Permeability; Dibenzazepines; Dinoprostone; Dose-Response Relationship, Drug; Free Radical Scavengers; Guinea Pigs; Histamine; Histamine H1 Antagonists; Histamine Release; Ileum; Imidazoles; In Vitro Techniques; Intramolecular Oxidoreductases; Ketotifen; Leukotriene B4; Leukotriene C4; Lipocalins; Lung; Male; Mice; Mice, Inbred ICR; Muscle Contraction; Piperidines; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Respiratory Hypersensitivity; Serotonin; Sheep; Skin Physiological Phenomena; Trachea	1998
Is histamine involved in milk ejection in goats? Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1999, Volume: 48 Suppl 1 Topics: Animals; Female; Goats; Histamine; Histamine Antagonists; Histamine H1 Antagonists; Imidazoles; Ketotifen; Lactation; Mammary Glands, Animal; Milk Ejection; Oxytocin	1999
Importance of histamine, glutathione and oxyradicals in modulating gastric haemorrhagic ulcer in septic rats. Clinical and experimental pharmacology & physiology, 2000, Volume: 27, Issue:4 Topics: Amine Oxidase (Copper-Containing); Animals; Dose-Response Relationship, Drug; Free Radical Scavengers; Gastric Mucosa; Glutathione; Hemoglobins; Histamine; Histamine Release; Hydrochloric Acid; Ketotifen; Lipid Peroxidation; Lipopolysaccharides; Male; Peptic Ulcer Hemorrhage; Rats; Rats, Wistar; Reactive Oxygen Species; Sepsis; Sodium Chloride; Stomach; Stomach Ulcer; Zinc Sulfate	2000
Influence of IgE-mediated activation of cultured human mast cells on proliferation and type I collagen production by human dermal fibroblasts. The Journal of allergy and clinical immunology, 2000, Volume: 106, Issue:1 Pt 2 Topics: Cell Division; Cells, Cultured; Collagen; Dose-Response Relationship, Drug; Fibroblasts; Histamine; Humans; Immunoglobulin E; Ketotifen; Mast Cells	2000
VUF-K-8788, a periphery-selective histamine H1 antagonist with anti-pruritic activities. Japanese journal of pharmacology, 2001, Volume: 86, Issue:1 Topics: Animals; Anti-Allergic Agents; Behavior, Animal; Benzimidazoles; Capillary Permeability; Guinea Pigs; Histamine; Histamine H1 Antagonists; In Vitro Techniques; Ketotifen; Lung; Male; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Muscle Contraction; Passive Cutaneous Anaphylaxis; Peripheral Nervous System; Piperazines; Pruritus; Pyrilamine; Rats; Rats, Wistar; Terfenadine; Thiazines	2001
Antipruritic activity of the kappa-opioid receptor agonist, TRK-820. European journal of pharmacology, 2002, Jan-25, Volume: 435, Issue:2-3 Topics: Animals; Antipruritics; Chlorpheniramine; Disease Models, Animal; Histamine; Histamine H1 Antagonists; Ketotifen; Male; Mice; Mice, Inbred ICR; Morphinans; Motor Activity; Naltrexone; Pruritus; Receptors, Opioid, kappa; Spiro Compounds; Substance P	2002
Role of histamine in aggravation of gastric acid back-diffusion and vascular permeability in septic rats. The Chinese journal of physiology, 2001, Dec-31, Volume: 44, Issue:4 Topics: Amine Oxidase (Copper-Containing); Animals; Bacterial Infections; Capillary Permeability; Diffusion; Gastric Acid; Gastric Mucosa; Gastrointestinal Hemorrhage; Histamine; Histamine H1 Antagonists; Histamine H2 Antagonists; Hydrochloric Acid; Ketotifen; Male; Microcirculation; Ranitidine; Rats; Rats, Wistar; Sodium Chloride; Stomach; Stomach Ulcer	2001
Role of Rho-associated protein kinase and histamine in lysophosphatidic acid-induced airway hyperresponsiveness in guinea pigs. Japanese journal of pharmacology, 2002, Volume: 88, Issue:3 Topics: Acetylcholine; Amides; Animals; Bronchial Hyperreactivity; Enzyme Inhibitors; Guinea Pigs; Histamine; Histamine H1 Antagonists; Histamine Release; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Ketotifen; Lung; Lysophospholipids; Male; Muscle Contraction; Muscle, Smooth; Protein Serine-Threonine Kinases; Pyridines; Pyrilamine; rho-Associated Kinases; Structure-Activity Relationship	2002
Alteration of CCK-induced satiety in post-Nippostrongylus brasiliensis-infected rats. Brain, behavior, and immunity, 2003, Volume: 17, Issue:1 Topics: Animals; Benzodiazepinones; Cell Degranulation; Cholecystokinin; Devazepide; Eating; Histamine; Histamine H1 Antagonists; Hormone Antagonists; Ketotifen; Male; Mast Cells; Nippostrongylus; Phenylurea Compounds; Rats; Rats, Wistar; Receptors, Cholecystokinin; Satiety Response; Serotonin; Strongylida Infections	2003
Effect of dehydroleucodine on histamine and serotonin release from mast cells in the isolated mouse jejunum. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2003, Volume: 52, Issue:5 Topics: Animals; Anti-Ulcer Agents; Histamine; Histamine H1 Antagonists; Image Processing, Computer-Assisted; In Vitro Techniques; Jejunum; Ketotifen; Lactones; Male; Mast Cells; Mice; Mice, Inbred BALB C; Microscopy, Electron; Microscopy, Video; p-Methoxy-N-methylphenethylamine; Serotonin; Sesquiterpenes	2003
Activation of mast cells induced by agonists of proteinase-activated receptors under normal conditions and during acute inflammation in rats. European journal of pharmacology, 2003, Jun-20, Volume: 471, Issue:2 Topics: Acute Disease; Animals; beta-N-Acetylhexosaminidases; Cell Degranulation; Dose-Response Relationship, Drug; Histamine; Inflammation; Injections, Intraperitoneal; Ketotifen; Male; Mast Cells; p-Methoxy-N-methylphenethylamine; Peptide Fragments; Peritoneum; Peritonitis; Rats; Rats, Wistar; Receptor, PAR-1; Receptors, Proteinase-Activated; Receptors, Thrombin; Thioglycolates; Thrombin; Trypsin	2003
Release of TNF-alpha during myocardial reperfusion depends on oxidative stress and is prevented by mast cell stabilizers. Cardiovascular research, 2003, Dec-01, Volume: 60, Issue:3 Topics: ADAM Proteins; ADAM17 Protein; Animals; Cell Line; Histamine; Histamine H1 Antagonists; Ketotifen; Male; Mast Cells; Metalloendopeptidases; Myocardial Ischemia; Myocardial Reperfusion; Oxidative Stress; Perfusion; Rats; Rats, Wistar; RNA, Messenger; Time Factors; Tumor Necrosis Factor-alpha	2003
Effects of nonsteroidal anti-inflammatory drugs on experimental allergic conjunctivitis in Guinea pigs. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2003, Volume: 19, Issue:6 Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens; Benzophenones; Benzopyrans; Bromobenzenes; Conjunctivitis, Allergic; Diclofenac; Dinoprostone; Disease Models, Animal; Evans Blue; Exudates and Transudates; Eye; Guinea Pigs; Histamine; Histamine Release; Immunization; Injections, Intraperitoneal; Injections, Subcutaneous; Ketotifen; Male; Ovalbumin; Propionates; Prostaglandin D2; Pruritus; Therapeutic Irrigation	2003
Role of histamine and acid back-diffusion in modulation of gastric microvascular permeability and hemorrhagic ulcers in Salmonella typhimurium-infected rats. Life sciences, 2004, Mar-05, Volume: 74, Issue:16 Topics: Amine Oxidase (Copper-Containing); Animals; Capillary Permeability; Diphenhydramine; Disease Models, Animal; Gastric Acid; Gastric Mucosa; Histamine; Ketotifen; Peptic Ulcer Hemorrhage; Ranitidine; Rats; Rats, Wistar; Salmonella Infections, Animal; Salmonella typhimurium; Stomach Ulcer	2004
Degranulation of mast cells located in median eminence in response to compound 48/80 evokes adrenocortical secretion via histamine and CRF in dogs. American journal of physiology. Regulatory, integrative and comparative physiology, 2004, Volume: 287, Issue:4 Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Animals; Cell Degranulation; Chromatography, Thin Layer; Corticotropin-Releasing Hormone; Dogs; Dose-Response Relationship, Drug; Epinephrine; Female; Hemodynamics; Histamine; Histamine H1 Antagonists; Histamine H2 Antagonists; Hydrocortisone; Injections, Intraventricular; Ketotifen; Male; Median Eminence; Metiamide; p-Methoxy-N-methylphenethylamine; Pyrilamine; Splanchnic Circulation	2004
Antipruritic and antierythema effects of ascomycete Bulgaria inquinans extract in ICR Mice. Biological & pharmaceutical bulletin, 2005, Volume: 28, Issue:12 Topics: Administration, Oral; Animals; Ascomycota; Behavior, Animal; Capillary Permeability; Complex Mixtures; Cyproheptadine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Erythema; Female; Histamine; Ketotifen; Male; Mast Cells; Mice; Mice, Inbred ICR; p-Methoxy-N-methylphenethylamine; Pruritus; Rats; Rats, Wistar; Serotonin; Suspensions	2005
Nasal congestion model in Brown Norway rats and the effects of some H1-antagonists. International immunopharmacology, 2006, Volume: 6, Issue:5 Topics: Animals; Chlorpheniramine; Dibenzazepines; Disease Models, Animal; Histamine; Histamine H1 Antagonists; Imidazoles; Ketotifen; Male; Nasal Mucosa; Plethysmography, Whole Body; Rats; Rats, Inbred BN; Rhinitis; Toluene 2,4-Diisocyanate	2006
Effects of KP-496, a novel dual antagonist for leukotriene D4 and thromboxane A2 receptors, on contractions induced by various agonists in the guinea pig trachea. Allergology international : official journal of the Japanese Society of Allergology, 2006, Volume: 55, Issue:4 Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetates; Acetylcholine; Albuterol; Animals; Atropine; Benzoquinones; Carbachol; Chromones; Cyclopropanes; Dinoprost; Drug Evaluation, Preclinical; Guinea Pigs; Heptanoic Acids; Histamine; In Vitro Techniques; Indoles; Indomethacin; Ketanserin; Ketotifen; Leukotriene Antagonists; Leukotriene D4; Male; Muscle Contraction; Muscle, Smooth; Phenylcarbamates; Powders; Procaterol; Prostaglandin Antagonists; Prostaglandin D2; Quinolines; Receptors, Thromboxane A2, Prostaglandin H2; Serotonin; Substance P; Sulfides; Sulfonamides; Tosyl Compounds; Trachea; Tryptophan	2006
Establishment of an allergic rhinitis model in mice for the evaluation of nasal symptoms. Life sciences, 2007, Mar-20, Volume: 80, Issue:15 Topics: Animals; Anti-Allergic Agents; Anti-Inflammatory Agents; Antigens; Cryptomeria; Dexamethasone; Disease Models, Animal; Eosinophils; Female; Histamine; Immunization; Immunoglobulin E; Ketotifen; Mice; Nasal Mucosa; Peroxidases; Pollen; Rhinitis, Allergic, Seasonal; Sneezing	2007
Duration of action of topical antiallergy drugs in a Guinea pig model of histamine-induced conjunctival vascular permeability. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2007, Volume: 23, Issue:4 Topics: Administration, Topical; Animals; Anti-Allergic Agents; Capillary Permeability; Conjunctiva; Delayed-Action Preparations; Dibenzazepines; Dibenzoxepins; Dose-Response Relationship, Drug; Guinea Pigs; Histamine; Histamine H1 Antagonists; Imidazoles; Ketotifen; Male; Olopatadine Hydrochloride; Ophthalmic Solutions; Phthalazines	2007
Evidence for a role of mast cells in the mucosal injury induced by Newcastle disease virus. Poultry science, 2009, Volume: 88, Issue:3 Topics: Animals; Chickens; Gene Expression Regulation, Enzymologic; Histamine; Intestinal Mucosa; Ketotifen; Mast Cells; Newcastle Disease; Newcastle disease virus; Proventriculus; Specific Pathogen-Free Organisms; Stomach; Tryptases	2009
Compound 48/80 causes oxidative stress in the adrenal gland of rats through mast cell degranulation. Free radical research, 2010, Volume: 44, Issue:2 Topics: Adrenal Glands; alpha-Tocopherol; Animals; Cell Degranulation; Corticosterone; Histamine; Injections, Intraperitoneal; Ketotifen; Male; Mast Cells; Oxidative Stress; p-Methoxy-N-methylphenethylamine; Rats; Rats, Wistar; Serotonin	2010
Effect of histamine H1 receptor antagonists on TARC/CCL17 and MDC/CCL22 production from CD14+ cells induced by antigenic stimulation in vitro. International archives of allergy and immunology, 2011, Volume: 155, Issue:1 Topics: Adult; Antigens, Plant; Cell Proliferation; Chemokine CCL17; Chemokine CCL22; Chlorpheniramine; Extracellular Signal-Regulated MAP Kinases; GATA1 Transcription Factor; Gene Expression; Histamine; Histamine H1 Antagonists; Humans; Ketotifen; Leukocytes, Mononuclear; Lipopolysaccharide Receptors; Macrophages; Male; Middle Aged; NF-kappa B; Phosphorylation; Phthalazines; Piperazines; Plant Proteins; Rhinitis, Allergic, Seasonal; Signal Transduction; Terfenadine; Tuberculin; Young Adult	2011
Phytopharmacological evaluation and anti-asthmatic activity of Ficus religiosa leaves. Asian Pacific journal of tropical medicine, 2011, Volume: 4, Issue:8 Topics: Acetylcholine; Aminophylline; Animals; Anti-Allergic Agents; Anti-Asthmatic Agents; Asthma; Bronchial Spasm; Cell Degranulation; Dose-Response Relationship, Drug; Dyspnea; Female; Ficus; Guinea Pigs; Histamine; Ketotifen; Male; Mast Cells; Phytotherapy; Plant Extracts; Plant Leaves; Rats	2011
Involvement of chymase in allergic conjunctivitis of guinea pigs. Experimental eye research, 2013, Volume: 113 Topics: Allergens; Animals; Chymases; Conjunctivitis, Allergic; Disease Models, Animal; Enzyme Inhibitors; Guinea Pigs; Histamine; Histamine H1 Antagonists; Histamine Release; Ketotifen; Male; Mast Cells; Pollen; Pruritus; Recombinant Proteins	2013
Punishing and cardiovascular effects of intravenous histamine in rats: pharmacological selectivity. Journal of the experimental analysis of behavior, 2013, Volume: 100, Issue:3 Topics: Animals; Cardiovascular System; Conditioning, Operant; Dose-Response Relationship, Drug; Heart Rate; Histamine; Histamine Antagonists; Injections, Intravenous; Ketotifen; Male; Punishment; Pyrilamine; Ranitidine; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology	2013
Effects of anti-histamine treatment on liver injury triggered by small intestinal ischemia reperfusion in rats. The Chinese journal of physiology, 2014, Oct-31, Volume: 57, Issue:5 Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Cell Degranulation; Histamine; Histamine H1 Antagonists; Interleukin-8; Intestine, Small; Ketotifen; Liver; Liver Diseases; Mast Cells; p-Methoxy-N-methylphenethylamine; Rats, Sprague-Dawley; Reperfusion Injury; Treatment Outcome; Tumor Necrosis Factor-alpha	2014
Dietary cholesterol is essential to mast cell activation and associated obesity and diabetes in mice. Biochimica et biophysica acta. Molecular basis of disease, 2019, 06-01, Volume: 1865, Issue:6 Topics: Adipose Tissue; Animals; Anti-Allergic Agents; Anti-Asthmatic Agents; beta-N-Acetylhexosaminidases; Cell Degranulation; Cholesterol, Dietary; Cholesterol, LDL; Cromolyn Sodium; Diabetes Mellitus, Experimental; Diet, High-Fat; Gene Expression; Histamine; Ketotifen; Male; Mast Cells; Mice; Mice, Inbred C57BL; Mice, Knockout; Obesity; Receptors, LDL; Serotonin; Signal Transduction; Streptozocin	2019
Inhibition of Mast Cell Degranulation Relieves Visceral Hypersensitivity Induced by Pancreatic Carcinoma in Mice. Journal of molecular neuroscience : MN, 2019, Volume: 69, Issue:2 Topics: Adult; Animals; Cancer Pain; Carcinoma; Cell Degranulation; Female; Histamine; Histamine H1 Antagonists; Humans; Ketotifen; Male; Mast Cells; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Middle Aged; Nerve Growth Factor; Pancreatic Neoplasms; Secretagogues; Tryptases; Visceral Pain	2019