ketoprofen-lysine and acetylcellulose

ketoprofen-lysine has been researched along with acetylcellulose* in 1 studies

Other Studies

1 other study(ies) available for ketoprofen-lysine and acetylcellulose

Article	Year
Core/shell cellulose-based microspheres for oral administration of Ketoprofen Lysinate. Journal of biomedical materials research. Part B, Applied biomaterials, 2018, Volume: 106, Issue:7 Herein, we propose the fabrication of a new carrier with core/shell structure-inner core of cellulose acetate (CA) coated by a micrometric layer of chitosan (CS)-fabricated through an integrated process, which combines Electro Dynamic Atomization (EDA) and layer-by-layer (LbL) technique. We demonstrate that CA based microspheres possess a unique capability to relevantly retain the drugs-that is, Ketoprofen Lysinate (KL)-along the gastric tract, while providing a massive release along the intestine. CS shell slightly influences the morphology and water retention under different pH conditions, improving drug encapsulation without compromising drug release kinetics. In vitro studies in simulated gastric and intestine fluids (SGF, SIF) with physiological enzymes, show a moderate release of LSK during the first 2 h (ca. 20% at pH 2), followed by a sustained release during the next 6 h (ca. 80% at pH 7). The obtained results demonstrate that CA-based microspheres hold strong potential to be used as carriers for a delayed oral administration of anti-inflammatory drugs. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2636-2644, 2018. Topics: Administration, Oral; Cellulose; Chitosan; Delayed-Action Preparations; Hydrogen-Ion Concentration; Ketoprofen; Lysine; Microspheres	2018

Article

Year

Core/shell cellulose-based microspheres for oral administration of Ketoprofen Lysinate.

Journal of biomedical materials research. Part B, Applied biomaterials, 2018, Volume: 106, Issue:7

Herein, we propose the fabrication of a new carrier with core/shell structure-inner core of cellulose acetate (CA) coated by a micrometric layer of chitosan (CS)-fabricated through an integrated process, which combines Electro Dynamic Atomization (EDA) and layer-by-layer (LbL) technique. We demonstrate that CA based microspheres possess a unique capability to relevantly retain the drugs-that is, Ketoprofen Lysinate (KL)-along the gastric tract, while providing a massive release along the intestine. CS shell slightly influences the morphology and water retention under different pH conditions, improving drug encapsulation without compromising drug release kinetics. In vitro studies in simulated gastric and intestine fluids (SGF, SIF) with physiological enzymes, show a moderate release of LSK during the first 2 h (ca. 20% at pH 2), followed by a sustained release during the next 6 h (ca. 80% at pH 7). The obtained results demonstrate that CA-based microspheres hold strong potential to be used as carriers for a delayed oral administration of anti-inflammatory drugs. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2636-2644, 2018.

Topics: Administration, Oral; Cellulose; Chitosan; Delayed-Action Preparations; Hydrogen-Ion Concentration; Ketoprofen; Lysine; Microspheres

2018