ketoprofen glucuronide has been researched along with ketoprofen in 15 studies
| Studies (ketoprofen glucuronide) | Trials (ketoprofen glucuronide) | Recent Studies (post-2010) (ketoprofen glucuronide) | Studies (ketoprofen) | Trials (ketoprofen) | Recent Studies (post-2010) (ketoprofen) |
|---|---|---|---|---|---|
| 17 | 1 | 3 | 3,089 | 677 | 1,008 |
| Protein | Taxonomy | ketoprofen glucuronide (IC50) | ketoprofen (IC50) |
|---|---|---|---|
| Solute carrier family 22 member 6 | Rattus norvegicus (Norway rat) | 0.5 | |
| Prostaglandin G/H synthase 1 | Ovis aries (sheep) | 1.1942 | |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | 0.008 | |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | 1.168 | |
| Prostaglandin G/H synthase 2 | Ovis aries (sheep) | 0.18 | |
| Solute carrier family 22 member 6 | Homo sapiens (human) | 1.35 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (46.67) | 18.2507 |
| 2000's | 5 (33.33) | 29.6817 |
| 2010's | 3 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fujiwara, R; Koga, T; Nakajima, M; Yokoi, T | 1 |
| Bochner, F; Hayball, PJ; Nation, RL | 1 |
| Abiteboul, M; Dubois-Presle, N; Fournel-Gigleux, S; Lapicque, F; Magdalou, J; Maurice, MH; Netter, P; Siest, G | 1 |
| Grubb, NG; Hall, SD; Rudy, DW | 1 |
| Fournel-Gigleux, S; Lapicque, F; Magdalou, J; Netter, P; Presle, N | 1 |
| Benoit, E; Fournel-Gigleux, S; Lapicque, F; Magdalou, J; Radominska-Pandya, A; Senay, C; Terrier, N | 1 |
| Meunier, CJ; Verbeeck, RK | 1 |
| Brater, DC; Grubb, NG; Hall, SD; Rudy, DW | 1 |
| Burchell, B; Coffey, MJ; Findlay, KA; Riley, RJ; Soars, MG | 1 |
| Hansen, SH; Mortensen, RW; Sidelmann, UG; Tjørnelund, J | 1 |
| Benoit, E; Blondeau, C; Chapleur, Y; Chretien, F; Grandcolas, L; Guillaume, C; Jouzeau, JY; Lapicque, F; Levoin, N; Netter, P | 1 |
| Lindon, JC; Nicholson, JK; Skordi, E; Wilson, ID | 1 |
| Chen, X; He, H; Song, X; Xing, Y; Yang, J; Yu, Q; Zhai, D; Zhao, Y | 1 |
| Goto, T; Lee, SH; Oe, T; Osaki, F | 1 |
| Iwaki, M; Kawase, A; Kobayashi, Y; Ogiso, T; Shimada, H; Tanahashi, S | 1 |
1 trial(s) available for ketoprofen glucuronide and ketoprofen
| Article | Year |
|---|---|
Stereoselective pharmacokinetics of ketoprofen and ketoprofen glucuronide in end-stage renal disease: evidence for a 'futile cycle' of elimination.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Chromatography, High Pressure Liquid; Female; Half-Life; Humans; Ketoprofen; Kidney Failure, Chronic; Male; Middle Aged; Renal Dialysis; Stereoisomerism; Time Factors | 1999 |
14 other study(ies) available for ketoprofen glucuronide and ketoprofen
| Article | Year |
|---|---|
Toxicological evaluation of acyl glucuronides of nonsteroidal anti-inflammatory drugs using human embryonic kidney 293 cells stably expressing human UDP-glucuronosyltransferase and human hepatocytes.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Camphanes; Comet Assay; DNA Damage; Glucuronides; Glucuronosyltransferase; HEK293 Cells; Hepatocytes; Humans; Kidney | 2011 |
Stereoselective interactions of ketoprofen glucuronides with human plasma protein and serum albumin.
Topics: Adult; Blood Proteins; Diazepam; Esters; Female; Humans; Hydrolysis; Ketoprofen; Male; Middle Aged; Protein Binding; Serum Albumin; Warfarin | 1992 |
Stereoselective esterase activity of human serum albumin toward ketoprofen glucuronide.
Topics: Binding Sites; Circular Dichroism; Esterases; Humans; Hydrolysis; Ketoprofen; Kinetics; Sensitivity and Specificity; Serum Albumin; Stereoisomerism | 1995 |
Stereoselective high-performance liquid chromatographic analysis of ketoprofen and its acyl glucuronides in chronic renal insufficiency.
Topics: Acylation; Chromatography, High Pressure Liquid; Dialysis Solutions; Glucuronates; Humans; Hydrogen-Ion Concentration; Hydrolysis; Ketoprofen; Kinetics; Renal Insufficiency; Sensitivity and Specificity; Spectrometry, Mass, Fast Atom Bombardment; Stereoisomerism | 1996 |
Stereoselective irreversible binding of ketoprofen glucuronides to albumin. Characterization of the site and the mechanism.
Topics: Animals; Humans; Ketoprofen; Ligands; Microsomes, Liver; Protein Binding; Rats; Serum Albumin; Stereoisomerism | 1996 |
Human and rat liver UDP-glucuronosyltransferases are targets of ketoprofen acylglucuronide.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Cricetinae; Enzyme Inhibitors; Glucuronosyltransferase; Humans; Ketoprofen; Microsomes, Liver; Rats | 1999 |
Glucuronidation kinetics of R,S-ketoprofen in adjuvant-induced arthritic rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Biliary Tract; Ketoprofen; Kinetics; Male; Protein Binding; Rats; Rats, Wistar; Serum Albumin; Stereoisomerism | 1999 |
Evidence for significant differences in microsomal drug glucuronidation by canine and human liver and kidney.
Topics: Adult; Androstane-3,17-diol; Animals; Dogs; Female; Furosemide; Gemfibrozil; Glucuronidase; Glucuronides; Humans; Ketoprofen; Kidney; Kinetics; Male; Microsomes; Microsomes, Liver; Middle Aged; Models, Animal; Propofol; Species Specificity | 2001 |
Stereospecific pH-dependent degradation kinetics of R- and S-naproxen-beta-l-O-acyl-glucuronide.
Topics: Animals; Chromatography, High Pressure Liquid; Drug Stability; Female; Glucuronides; Hydrogen-Ion Concentration; In Vitro Techniques; Ketoprofen; Kinetics; Microsomes, Liver; Naproxen; Stereoisomerism; Swine | 2002 |
Elucidation of the mechanism of inhibition of cyclooxygenases by acyl-coenzyme A and acylglucuronic conjugates of ketoprofen.
Topics: Acyl Coenzyme A; Acylation; Animals; Cattle; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Isoenzymes; Ketoprofen; Membrane Proteins; Mice; Models, Molecular; Prostaglandin-Endoperoxide Synthases | 2004 |
Kinetic studies on the intramolecular acyl migration of beta-1-O-acyl glucuronides: application to the glucuronides of (R)- and (S)-ketoprofen, (R)- and (S)-hydroxy-ketoprofen metabolites, and tolmetin by 1H-NMR spectroscopy.
Topics: Buffers; Glucuronic Acid; Ketoprofen; Kinetics; Magnetic Resonance Spectroscopy; Stereoisomerism; Tolmetin | 2005 |
Ketoprofen glucuronidation and bile excretion in carbon tetrachloride and alpha-naphthylisothiocyanate induced hepatic injury rats.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Bile; Bilirubin; Blood Urea Nitrogen; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Histocytochemistry; Isocyanates; Ketoprofen; Liver; Liver Diseases; Male; Microsomes, Liver; Naphthalenes; Random Allocation; Rats; Rats, Sprague-Dawley | 2007 |
Predicted multiple selected reaction monitoring to screen activated drug-mediated modifications on human serum albumin.
Topics: Amino Acid Sequence; Benzoquinones; Binding Sites; Cysteine; Humans; Imines; Ketoprofen; Lysine; Mass Spectrometry; Molecular Sequence Data; Pharmaceutical Preparations; Protein Binding; Serum Albumin | 2014 |
Correlation between glucuronidation and covalent adducts formation with proteins of nonsteroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzopyrans; Flurbiprofen; Glucuronides; Ibuprofen; Ketoprofen; Male; Microsomes, Liver; Naproxen; Propionates; Protein Binding; Rats, Wistar | 2018 |