Page last updated: 2024-09-03

ketoprofen glucuronide and ketoprofen

ketoprofen glucuronide has been researched along with ketoprofen in 15 studies

Compound Research Comparison

Studies
(ketoprofen glucuronide)
Trials
(ketoprofen glucuronide)
Recent Studies (post-2010)
(ketoprofen glucuronide)
Studies
(ketoprofen)
Trials
(ketoprofen)
Recent Studies (post-2010) (ketoprofen)
17133,0896771,008

Protein Interaction Comparison

ProteinTaxonomyketoprofen glucuronide (IC50)ketoprofen (IC50)
Solute carrier family 22 member 6Rattus norvegicus (Norway rat)0.5
Prostaglandin G/H synthase 1Ovis aries (sheep)1.1942
Prostaglandin G/H synthase 1Homo sapiens (human)0.008
Prostaglandin G/H synthase 2Homo sapiens (human)1.168
Prostaglandin G/H synthase 2Ovis aries (sheep)0.18
Solute carrier family 22 member 6Homo sapiens (human)1.35

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's7 (46.67)18.2507
2000's5 (33.33)29.6817
2010's3 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fujiwara, R; Koga, T; Nakajima, M; Yokoi, T1
Bochner, F; Hayball, PJ; Nation, RL1
Abiteboul, M; Dubois-Presle, N; Fournel-Gigleux, S; Lapicque, F; Magdalou, J; Maurice, MH; Netter, P; Siest, G1
Grubb, NG; Hall, SD; Rudy, DW1
Fournel-Gigleux, S; Lapicque, F; Magdalou, J; Netter, P; Presle, N1
Benoit, E; Fournel-Gigleux, S; Lapicque, F; Magdalou, J; Radominska-Pandya, A; Senay, C; Terrier, N1
Meunier, CJ; Verbeeck, RK1
Brater, DC; Grubb, NG; Hall, SD; Rudy, DW1
Burchell, B; Coffey, MJ; Findlay, KA; Riley, RJ; Soars, MG1
Hansen, SH; Mortensen, RW; Sidelmann, UG; Tjørnelund, J1
Benoit, E; Blondeau, C; Chapleur, Y; Chretien, F; Grandcolas, L; Guillaume, C; Jouzeau, JY; Lapicque, F; Levoin, N; Netter, P1
Lindon, JC; Nicholson, JK; Skordi, E; Wilson, ID1
Chen, X; He, H; Song, X; Xing, Y; Yang, J; Yu, Q; Zhai, D; Zhao, Y1
Goto, T; Lee, SH; Oe, T; Osaki, F1
Iwaki, M; Kawase, A; Kobayashi, Y; Ogiso, T; Shimada, H; Tanahashi, S1

Trials

1 trial(s) available for ketoprofen glucuronide and ketoprofen

ArticleYear
Stereoselective pharmacokinetics of ketoprofen and ketoprofen glucuronide in end-stage renal disease: evidence for a 'futile cycle' of elimination.
    British journal of clinical pharmacology, 1999, Volume: 48, Issue:4

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Chromatography, High Pressure Liquid; Female; Half-Life; Humans; Ketoprofen; Kidney Failure, Chronic; Male; Middle Aged; Renal Dialysis; Stereoisomerism; Time Factors

1999

Other Studies

14 other study(ies) available for ketoprofen glucuronide and ketoprofen

ArticleYear
Toxicological evaluation of acyl glucuronides of nonsteroidal anti-inflammatory drugs using human embryonic kidney 293 cells stably expressing human UDP-glucuronosyltransferase and human hepatocytes.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Camphanes; Comet Assay; DNA Damage; Glucuronides; Glucuronosyltransferase; HEK293 Cells; Hepatocytes; Humans; Kidney

2011
Stereoselective interactions of ketoprofen glucuronides with human plasma protein and serum albumin.
    Biochemical pharmacology, 1992, Jul-22, Volume: 44, Issue:2

    Topics: Adult; Blood Proteins; Diazepam; Esters; Female; Humans; Hydrolysis; Ketoprofen; Male; Middle Aged; Protein Binding; Serum Albumin; Warfarin

1992
Stereoselective esterase activity of human serum albumin toward ketoprofen glucuronide.
    Molecular pharmacology, 1995, Volume: 47, Issue:3

    Topics: Binding Sites; Circular Dichroism; Esterases; Humans; Hydrolysis; Ketoprofen; Kinetics; Sensitivity and Specificity; Serum Albumin; Stereoisomerism

1995
Stereoselective high-performance liquid chromatographic analysis of ketoprofen and its acyl glucuronides in chronic renal insufficiency.
    Journal of chromatography. B, Biomedical applications, 1996, Apr-12, Volume: 678, Issue:2

    Topics: Acylation; Chromatography, High Pressure Liquid; Dialysis Solutions; Glucuronates; Humans; Hydrogen-Ion Concentration; Hydrolysis; Ketoprofen; Kinetics; Renal Insufficiency; Sensitivity and Specificity; Spectrometry, Mass, Fast Atom Bombardment; Stereoisomerism

1996
Stereoselective irreversible binding of ketoprofen glucuronides to albumin. Characterization of the site and the mechanism.
    Drug metabolism and disposition: the biological fate of chemicals, 1996, Volume: 24, Issue:10

    Topics: Animals; Humans; Ketoprofen; Ligands; Microsomes, Liver; Protein Binding; Rats; Serum Albumin; Stereoisomerism

1996
Human and rat liver UDP-glucuronosyltransferases are targets of ketoprofen acylglucuronide.
    Molecular pharmacology, 1999, Volume: 56, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Cricetinae; Enzyme Inhibitors; Glucuronosyltransferase; Humans; Ketoprofen; Microsomes, Liver; Rats

1999
Glucuronidation kinetics of R,S-ketoprofen in adjuvant-induced arthritic rats.
    Pharmaceutical research, 1999, Volume: 16, Issue:7

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Biliary Tract; Ketoprofen; Kinetics; Male; Protein Binding; Rats; Rats, Wistar; Serum Albumin; Stereoisomerism

1999
Evidence for significant differences in microsomal drug glucuronidation by canine and human liver and kidney.
    Drug metabolism and disposition: the biological fate of chemicals, 2001, Volume: 29, Issue:2

    Topics: Adult; Androstane-3,17-diol; Animals; Dogs; Female; Furosemide; Gemfibrozil; Glucuronidase; Glucuronides; Humans; Ketoprofen; Kidney; Kinetics; Male; Microsomes; Microsomes, Liver; Middle Aged; Models, Animal; Propofol; Species Specificity

2001
Stereospecific pH-dependent degradation kinetics of R- and S-naproxen-beta-l-O-acyl-glucuronide.
    Chirality, 2002, May-05, Volume: 14, Issue:4

    Topics: Animals; Chromatography, High Pressure Liquid; Drug Stability; Female; Glucuronides; Hydrogen-Ion Concentration; In Vitro Techniques; Ketoprofen; Kinetics; Microsomes, Liver; Naproxen; Stereoisomerism; Swine

2002
Elucidation of the mechanism of inhibition of cyclooxygenases by acyl-coenzyme A and acylglucuronic conjugates of ketoprofen.
    Biochemical pharmacology, 2004, Nov-15, Volume: 68, Issue:10

    Topics: Acyl Coenzyme A; Acylation; Animals; Cattle; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Isoenzymes; Ketoprofen; Membrane Proteins; Mice; Models, Molecular; Prostaglandin-Endoperoxide Synthases

2004
Kinetic studies on the intramolecular acyl migration of beta-1-O-acyl glucuronides: application to the glucuronides of (R)- and (S)-ketoprofen, (R)- and (S)-hydroxy-ketoprofen metabolites, and tolmetin by 1H-NMR spectroscopy.
    Xenobiotica; the fate of foreign compounds in biological systems, 2005, Volume: 35, Issue:7

    Topics: Buffers; Glucuronic Acid; Ketoprofen; Kinetics; Magnetic Resonance Spectroscopy; Stereoisomerism; Tolmetin

2005
Ketoprofen glucuronidation and bile excretion in carbon tetrachloride and alpha-naphthylisothiocyanate induced hepatic injury rats.
    Toxicology, 2007, Feb-12, Volume: 230, Issue:2-3

    Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Bile; Bilirubin; Blood Urea Nitrogen; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Histocytochemistry; Isocyanates; Ketoprofen; Liver; Liver Diseases; Male; Microsomes, Liver; Naphthalenes; Random Allocation; Rats; Rats, Sprague-Dawley

2007
Predicted multiple selected reaction monitoring to screen activated drug-mediated modifications on human serum albumin.
    Analytical biochemistry, 2014, Mar-15, Volume: 449

    Topics: Amino Acid Sequence; Benzoquinones; Binding Sites; Cysteine; Humans; Imines; Ketoprofen; Lysine; Mass Spectrometry; Molecular Sequence Data; Pharmaceutical Preparations; Protein Binding; Serum Albumin

2014
Correlation between glucuronidation and covalent adducts formation with proteins of nonsteroidal anti-inflammatory drugs.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2018, Jan-15, Volume: 112

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzopyrans; Flurbiprofen; Glucuronides; Ibuprofen; Ketoprofen; Male; Microsomes, Liver; Naproxen; Propionates; Protein Binding; Rats, Wistar

2018