ketoprofen and metoprolol

ketoprofen has been researched along with metoprolol in 40 studies

Research

Studies (40)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	21 (52.50)	29.6817
2010's	18 (45.00)	24.3611
2020's	1 (2.50)	2.80

Authors

Authors	Studies
Danelian, E; Hämäläinen, MD; Hansson, A; Karlén, A; Karlsson, R; Lennernäs, H; Löfâs, S; Winiwarter, S	1
Topliss, JG; Yoshida, F	1
Faller, B; Wohnsland, F	1
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL	1
Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P	1
Caron, G; Ermondi, G	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Akamatsu, M; Fujikawa, M; Nakao, K; Shimizu, R	1
Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y	1
Lombardo, F; Obach, RS; Waters, NJ	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S	1
Conradi, R; Lee, PH; Shanmugasundaram, V	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Campillo, NE; Guerra, A; Páez, JA	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Avdeef, A; Tam, KY	1
Akamatsu, M	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Caradonna, NP; Hallifax, D; Houston, JB; Turlizzi, E; Zanelli, U	1
Barber, S; Dew, TP; Farrell, TL; Poquet, L; Williamson, G	1
Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ	1
Bellman, K; Knegtel, RM; Settimo, L	1
Beaumont, K; Di, L; Maurer, TS; Smith, DA	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Ahuja, VT; Allen, J; Bristow, LJ; Bronson, JJ; Brown, JM; Camac, D; Dandapani, K; Dokania, M; Dzierba, CD; Easton, A; Elavazhagan, S; Gulianello, M; Hamman, BD; Hartz, RA; Hunihan, L; Kiefer, SE; Kostich, W; Kumar, CMV; Lewis, M; Lippy, JS; Macor, JE; Muckelbauer, JK; Nara, SJ; Pattipati, SN; Rajamani, R; Surti, N	1
Amidon, GL; Hilgendorf, C; Langguth, P; Lipka, E; Regårdh, CG; Spahn-Langguth, H	1
Owens, PK; Svensson, LA	1
Chawla, S; Ghosh, S; Kumar, TR; Nellore, R; Sihorkar, V; Srinivas, NR	1
Galkin, A; Heinonen, M; Kreander, K; Laitinen, L; Tammela, P; Vuorela, P; Vuorela, S	1
Balwinski, KM; Mitchell, SA	1
Alwera, S; Bhushan, R	1
Abrahamsson, B; Dahlgren, D; Johansson, P; Lennernäs, H; Lundqvist, A; Roos, C; Sjögren, E; Tannergren, C	1
Abrahamsson, B; Dahlgren, D; Hellström, PM; Lennernäs, H; Lundqvist, A; Roos, C; Sjögren, E; Tannergren, C	1
Bermejo, M; González-Álvarez, I; González-Álvarez, M; Lozoya-Agullo, I; Merino-Sanjuán, M; Ortiz-Azcarate, M; Ruiz-Picazo, A	1
De Beer, T; De Bruyne, M; Dhondt, H; Van Renterghem, J; Verstraete, G; Vervaet, C	1

Reviews

1 review(s) available for ketoprofen and metoprolol

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

1 trial(s) available for ketoprofen and metoprolol

Article	Year
Regional Intestinal Permeability of Three Model Drugs in Human. Molecular pharmaceutics, 2016, 09-06, Volume: 13, Issue:9 Topics: Adolescent; Adult; Atenolol; Colon; Female; Humans; Ileum; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Jejunum; Ketoprofen; Male; Metoprolol; Middle Aged; Permeability; Young Adult	2016

Other Studies

38 other study(ies) available for ketoprofen and metoprolol

Article	Year
SPR biosensor studies of the direct interaction between 27 drugs and a liposome surface: correlation with fraction absorbed in humans. Journal of medicinal chemistry, 2000, Jun-01, Volume: 43, Issue:11 Topics: Humans; Intestinal Absorption; Liposomes; Pharmaceutical Preparations; Pharmacokinetics; Predictive Value of Tests; Surface Plasmon Resonance	2000
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
High-throughput permeability pH profile and high-throughput alkane/water log P with artificial membranes. Journal of medicinal chemistry, 2001, Mar-15, Volume: 44, Issue:6 Topics: Alkanes; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Membranes, Artificial; Octanols; Permeability; Pharmaceutical Preparations; Solubility; Water	2001
Cheminformatic models to predict binding affinities to human serum albumin. Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25 Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids	2001
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability. Journal of medicinal chemistry, 2004, Mar-25, Volume: 47, Issue:7 Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties	2004
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk). Journal of medicinal chemistry, 2005, May-05, Volume: 48, Issue:9 Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water	2005
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
QSAR study on permeability of hydrophobic compounds with artificial membranes. Bioorganic & medicinal chemistry, 2007, Jun-01, Volume: 15, Issue:11 Topics: Biological Transport; Caco-2 Cells; Drug Evaluation, Preclinical; Humans; Hydrophobic and Hydrophilic Interactions; Membranes, Artificial; Permeability; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship	2007
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds. Bioorganic & medicinal chemistry, 2007, Nov-15, Volume: 15, Issue:22 Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
First-principle, structure-based prediction of hepatic metabolic clearance values in human. European journal of medicinal chemistry, 2009, Volume: 44, Issue:4 Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software	2009
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19 Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship	2009
Development of an in silico model for human skin permeation based on a Franz cell skin permeability assay. Bioorganic & medicinal chemistry letters, 2010, Jan-01, Volume: 20, Issue:1 Topics: 1-Methyl-3-isobutylxanthine; Cell Line; Cell Membrane Permeability; Humans; Models, Biological; Quantitative Structure-Activity Relationship; Skin Absorption	2010
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability? Journal of medicinal chemistry, 2010, May-13, Volume: 53, Issue:9 Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis	2010
Importance of physicochemical properties for the design of new pesticides. Journal of agricultural and food chemistry, 2011, Apr-13, Volume: 59, Issue:7 Topics: Anabasine; Animals; Biological Availability; Cell Membrane Permeability; Chemical Phenomena; Drug Design; Humans; Imidazoles; Insecticides; Neonicotinoids; Nitro Compounds; Pesticides; Quantitative Structure-Activity Relationship; Receptors, Nicotinic	2011
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1 Topics: Cell Line, Tumor; Cryopreservation; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Predictive Value of Tests	2012
Predicting phenolic acid absorption in Caco-2 cells: a theoretical permeability model and mechanistic study. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:2 Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Cinnamates; Enterocytes; Humans; Hydrophobic and Hydrophilic Interactions; Intestinal Absorption; Kinetics; Models, Biological; Molecular Conformation; Osmolar Concentration; Phenols	2012
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors. Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:1 Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity	2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
Volume of Distribution in Drug Design. Journal of medicinal chemistry, 2015, Aug-13, Volume: 58, Issue:15 Topics: Drug Design; Half-Life; Pharmacokinetics	2015
Discovery, Structure-Activity Relationships, and In Vivo Evaluation of Novel Aryl Amides as Brain Penetrant Adaptor Protein 2-Associated Kinase 1 (AAK1) Inhibitors for the Treatment of Neuropathic Pain. Journal of medicinal chemistry, 2021, 08-12, Volume: 64, Issue:15 Topics: Amides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Caco-2 Cells; Dose-Response Relationship, Drug; Drug Discovery; HEK293 Cells; Humans; Male; Mice; Mice, Inbred C57BL; Microsomes, Liver; Molecular Structure; Neuralgia; Protein Kinases; Protein Serine-Threonine Kinases; Structure-Activity Relationship	2021
Caco-2 versus Caco-2/HT29-MTX co-cultured cell lines: permeabilities via diffusion, inside- and outside-directed carrier-mediated transport. Journal of pharmaceutical sciences, 2000, Volume: 89, Issue:1 Topics: Antipyrine; Atenolol; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Caco-2 Cells; Carrier Proteins; Cell Membrane Permeability; Cellular Senescence; Coculture Techniques; Furosemide; HT29 Cells; Humans; Intestinal Absorption; Intestinal Mucosa; Ketoprofen; Mannitol; Metoprolol; Microscopy, Electron; Piroxicam; Reproducibility of Results; Terbutaline	2000
Enantioselective supercritical fluid chromatography using ristocetin A chiral stationary phases. The Analyst, 2000, Volume: 125, Issue:6 Topics: 2,4-Dichlorophenoxyacetic Acid; Anesthetics, Local; Anti-Bacterial Agents; Bupivacaine; Chromatography, Liquid; Coumarins; Evaluation Studies as Topic; Ketoprofen; Metoprolol; Propranolol; Reagent Kits, Diagnostic; Ristocetin; Stereoisomerism; Thalidomide; Warfarin	2000
High-performance liquid chromatography method development and validation for simultaneous determination of five model compounds, antipyrine, metoprolol, ketoprofen, furosemide and phenol red, as a tool for the standardization of rat in situ intestinal per Biomedical chromatography : BMC, 2006, Volume: 20, Issue:4 Topics: Animals; Antipyrine; Chromatography, High Pressure Liquid; Drug Stability; Furosemide; Intestinal Absorption; Ketoprofen; Metoprolol; Permeability; Phenolsulfonphthalein; Rats; Reproducibility of Results; Sensitivity and Specificity	2006
In-vitro mutagenic potential and effect on permeability of co-administered drugs across Caco-2 cell monolayers of Rubus idaeus and its fortified fractions. The Journal of pharmacy and pharmacology, 2006, Volume: 58, Issue:11 Topics: Acetaminophen; Anthocyanins; Biological Transport; Caco-2 Cells; Cell Membrane Permeability; Cell Survival; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Fluorenes; Fruit; Humans; Hydrolyzable Tannins; Ketoprofen; Metoprolol; Mutagenicity Tests; Plant Extracts; Rosaceae; Salmonella typhimurium; Spectrometry, Mass, Electrospray Ionization; Verapamil	2006
Investigation of hypromellose particle size effects on drug release from sustained release hydrophilic matrix tablets. Drug development and industrial pharmacy, 2007, Volume: 33, Issue:9 Topics: Acetaminophen; Caffeine; Chemistry, Pharmaceutical; Delayed-Action Preparations; Drug Carriers; Excipients; Hydrochlorothiazide; Hypromellose Derivatives; Ketoprofen; Methylcellulose; Metoprolol; Molecular Weight; Particle Size; Solubility; Tablets; Theophylline; Viscosity	2007
Liquid chromatographic enantioseparation of three beta-adrenolytics using new derivatizing reagents synthesized from (S)-ketoprofen and confirmation of configuration of diastereomers. Biomedical chromatography : BMC, 2016, Volume: 30, Issue:11 Topics: Adrenergic beta-Antagonists; Atenolol; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Ketoprofen; Limit of Detection; Metoprolol; Models, Molecular; Molecular Conformation; Propranolol; Stereoisomerism	2016
Regional Intestinal Permeability in Dogs: Biopharmaceutical Aspects for Development of Oral Modified-Release Dosage Forms. Molecular pharmaceutics, 2016, 09-06, Volume: 13, Issue:9 Topics: Animals; Atenolol; Dogs; Enalaprilat; Humans; Intestinal Absorption; Intestine, Large; Intestine, Small; Jejunum; Ketoprofen; Male; Metoprolol; Permeability	2016
Comparison of segmental-dependent permeability in human and in situ perfusion model in rat. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2017, Sep-30, Volume: 107 Topics: Animals; Atenolol; Colon; Humans; Ileum; Intestinal Absorption; Jejunum; Ketoprofen; Male; Metoprolol; Perfusion; Permeability; Rats, Wistar	2017
The impact of the injection mold temperature upon polymer crystallization and resulting drug release from immediate and sustained release tablets. International journal of pharmaceutics, 2018, Apr-25, Volume: 541, Issue:1-2 Topics: Chemistry, Pharmaceutical; Crystallization; Delayed-Action Preparations; Drug Compounding; Drug Liberation; Excipients; Hydrophobic and Hydrophilic Interactions; Ketoprofen; Metoprolol; Models, Chemical; Polymers; Solubility; Tablets; Temperature	2018