ketoprofen and methotrexate

ketoprofen has been researched along with methotrexate in 32 studies

Research

Studies (32)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (6.25)	18.7374
1990's	4 (12.50)	18.2507
2000's	14 (43.75)	29.6817
2010's	10 (31.25)	24.3611
2020's	2 (6.25)	2.80

Authors

Authors	Studies
Andricopulo, AD; Moda, TL; Montanari, CA	1
Apiwattanakul, N; Cha, SH; Endou, H; Kanai, Y; Nakajima, N; Sekine, T; Tsuda, M	1
Topliss, JG; Yoshida, F	1
Faller, B; Wohnsland, F	1
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL	1
Cha, SH; Endou, H; Hosoyamada, M; Khamdang, S; Kimura, H; Narikawa, S; Sekine, T; Takeda, M	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J	1
Lombardo, F; Obach, RS; Waters, NJ	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Campillo, NE; Guerra, A; Páez, JA	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Jadhav, A; Kerns, E; Nguyen, K; Shah, P; Sun, H; Xu, X; Yan, Z; Yu, KR	1
Kabir, M; Kerns, E; Nguyen, K; Shah, P; Sun, H; Wang, Y; Xu, X; Yu, KR	1
Kabir, M; Kerns, E; Neyra, J; Nguyen, K; Nguyễn, ÐT; Shah, P; Siramshetty, VB; Southall, N; Williams, J; Xu, X; Yu, KR	1
Kitchen, EA; Meacock, SC	1
Cambon, P; Milano, G; Perrin, A; Schneider, M; Thyss, A	1
Kubar, J; Milano, G; Namer, M; Schneider, M; Thyss, A	1
Bradley, JD; Brater, DC; Greene, PK; Tracy, TS; Worster, T	1
Inui, KI; Masuda, S; Saito, H	1
Balabanova, RM	1
Evans, AM; Hayball, PJ; Karpf, DM; Kirkegaard, AL; Milne, RW; Nation, RL	1
El-Haggar, SM; Elmorsi, YM; Ibrahim, OM; Mabrouk, MM	1
Allahyari, A; Arasteh, O; Askari, VR; Ataei Azimi, S; Hosseinjani, H; Jafari, F	1

Reviews

3 review(s) available for ketoprofen and methotrexate

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
[Current concepts of pharmacotherapy in rheumatoid arthritis]. Vestnik Rossiiskoi akademii meditsinskikh nauk, 2003, Issue:7 Topics: Adult; Aged; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclooxygenase Inhibitors; Cyclophosphamide; Cyclosporine; Double-Blind Method; Drug Therapy, Combination; Feasibility Studies; Female; Glucocorticoids; Humans; Ibuprofen; Immunosuppressive Agents; Isoxazoles; Ketoprofen; Leflunomide; Male; Methotrexate; Prednisolone; Prognosis; Randomized Controlled Trials as Topic; Risk Factors; Sulfasalazine; Time Factors	2003
A critical review of methotrexate clinical interactions: role of transporters. Expert opinion on drug metabolism & toxicology, 2023, Volume: 19, Issue:2 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Drug Interactions; Drug-Related Side Effects and Adverse Reactions; Humans; Ketoprofen; Membrane Transport Proteins; Methotrexate	2023

Trials

1 trial(s) available for ketoprofen and methotrexate

Article	Year
Methotrexate disposition following concomitant administration of ketoprofen, piroxicam and flurbiprofen in patients with rheumatoid arthritis. British journal of clinical pharmacology, 1994, Volume: 37, Issue:5 Topics: Administration, Oral; Adult; Aged; Arthritis, Rheumatoid; Drug Interactions; Drug Therapy, Combination; Female; Fluorescence Polarization Immunoassay; Flurbiprofen; Humans; Ketoprofen; Male; Metabolic Clearance Rate; Methotrexate; Middle Aged; Piroxicam	1994

Article

Year

Methotrexate disposition following concomitant administration of ketoprofen, piroxicam and flurbiprofen in patients with rheumatoid arthritis.

British journal of clinical pharmacology, 1994, Volume: 37, Issue:5

Topics: Administration, Oral; Adult; Aged; Arthritis, Rheumatoid; Drug Interactions; Drug Therapy, Combination; Female; Fluorescence Polarization Immunoassay; Flurbiprofen; Humans; Ketoprofen; Male; Metabolic Clearance Rate; Methotrexate; Middle Aged; Piroxicam

1994

Other Studies

28 other study(ies) available for ketoprofen and methotrexate

Article	Year
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Identification of multispecific organic anion transporter 2 expressed predominantly in the liver. FEBS letters, 1998, Jun-12, Volume: 429, Issue:2 Topics: Animals; Blotting, Northern; Carrier Proteins; Ion Transport; Liver; Membrane Proteins; Organic Anion Transporters, Sodium-Independent; Rats; Salicylates; Salicylic Acid; Substrate Specificity; Xenopus laevis	1998
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
High-throughput permeability pH profile and high-throughput alkane/water log P with artificial membranes. Journal of medicinal chemistry, 2001, Mar-15, Volume: 44, Issue:6 Topics: Alkanes; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Membranes, Artificial; Octanols; Permeability; Pharmaceutical Preparations; Solubility; Water	2001
Cheminformatic models to predict binding affinities to human serum albumin. Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25 Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids	2001
Characterization of methotrexate transport and its drug interactions with human organic anion transporters. The Journal of pharmacology and experimental therapeutics, 2002, Volume: 302, Issue:2 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Transport; Cells, Cultured; Humans; Indomethacin; Kinetics; Liver-Specific Organic Anion Transporter 1; Methotrexate; Mice; Mice, Transgenic; Nerve Tissue Proteins; Organic Anion Transporters, Sodium-Independent; Phenylbutazone; Potassium Channels; Potassium Channels, Tandem Pore Domain; Probenecid	2002
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Chemical genetics reveals a complex functional ground state of neural stem cells. Nature chemical biology, 2007, Volume: 3, Issue:5 Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19 Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
Highly predictive and interpretable models for PAMPA permeability. Bioorganic & medicinal chemistry, 2017, 02-01, Volume: 25, Issue:3 Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Humans; Models, Biological; Organic Chemicals; Regression Analysis; Support Vector Machine	2017
Predictive models of aqueous solubility of organic compounds built on A large dataset of high integrity. Bioorganic & medicinal chemistry, 2019, 07-15, Volume: 27, Issue:14 Topics: Drug Discovery; Organic Chemicals; Pharmaceutical Preparations; Solubility	2019
Retrospective assessment of rat liver microsomal stability at NCATS: data and QSAR models. Scientific reports, 2020, 11-26, Volume: 10, Issue:1 Topics: Animals; Computer Simulation; Databases, Factual; Drug Discovery; High-Throughput Screening Assays; Liver; Machine Learning; Male; Microsomes, Liver; National Center for Advancing Translational Sciences (U.S.); Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Rats; Rats, Sprague-Dawley; Retrospective Studies; United States	2020
Some effects of non-steroidal anti-inflammatory drugs on leucocyte migration. Agents and actions, 1976, Volume: 6, Issue:1-3 Topics: Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Cell Movement; Edema; Fenoprofen; Ibuprofen; Indomethacin; Ketoprofen; Leukocytes; Male; Methotrexate; Naproxen; Phenylbutazone; Pleurisy; Rats	1976
Biochemical and pharmacological consequences of the interaction between methotrexate and ketoprofen in the rabbit. British journal of cancer, 1990, Volume: 62, Issue:5 Topics: 6-Ketoprostaglandin F1 alpha; Animals; Drug Interactions; Female; Ketoprofen; Methotrexate; Protein Binding; Rabbits	1990
Clinical and pharmacokinetic evidence of a life-threatening interaction between methotrexate and ketoprofen. Lancet (London, England), 1986, Feb-01, Volume: 1, Issue:8475 Topics: Adolescent; Adult; Aged; Drug Interactions; Drug Therapy, Combination; Female; Humans; Ketoprofen; Kidney Diseases; Lymphoma; Male; Methotrexate; Middle Aged; Osteosarcoma; Phenylpropionates; Retrospective Studies; Time Factors	1986
Interactions of nonsteroidal anti-inflammatory drugs with rat renal organic anion transporter, OAT-K1. The Journal of pharmacology and experimental therapeutics, 1997, Volume: 283, Issue:3 Topics: Animals; Anion Transport Proteins; Anti-Inflammatory Agents, Non-Steroidal; Carrier Proteins; Drug Interactions; Indomethacin; Ketoprofen; Kidney; Male; Methotrexate; Rats; Rats, Wistar; Tetraethylammonium Compounds	1997
Effect of ketoprofen and its enantiomers on the renal disposition of methotrexate in the isolated perfused rat kidney. The Journal of pharmacy and pharmacology, 2003, Volume: 55, Issue:12 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites, Antineoplastic; Drug Interactions; Ketoprofen; Kidney; Male; Metabolic Clearance Rate; Methotrexate; Rats; Rats, Sprague-Dawley; Stereoisomerism	2003
Effect of ketoprofen and indomethacin on methotrexate pharmacokinetics in mice plasma and tumor tissues. European journal of drug metabolism and pharmacokinetics, 2013, Volume: 38, Issue:1 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites, Antineoplastic; Area Under Curve; Carcinoma, Ehrlich Tumor; Chromatography, High Pressure Liquid; Drug Interactions; Female; Half-Life; Indomethacin; Injections, Intraperitoneal; Ketoprofen; Metabolic Clearance Rate; Methotrexate; Mice; Multidrug Resistance-Associated Proteins	2013