ketoprofen and lidocaine

ketoprofen has been researched along with lidocaine in 66 studies

Research

Studies (66)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (6.06)18.2507
2000's28 (42.42)29.6817
2010's29 (43.94)24.3611
2020's5 (7.58)2.80

Authors

AuthorsStudies
Duffy, EM; Jorgensen, WL1
Topliss, JG; Yoshida, F1
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL1
Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P1
Caron, G; Ermondi, G1
Carrupt, PA; Martel, S; Ottaviani, G2
Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y1
Artursson, P; Bergström, CA; Draheim, R; Holmén, AG; Wassvik, CM1
Lombardo, F; Obach, RS; Waters, NJ1
He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S1
Conradi, R; Lee, PH; Shanmugasundaram, V1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Gozalbes, R; Pineda-Lucena, A1
Ekins, S; Williams, AJ; Xu, JJ1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K1
Caradonna, NP; Hallifax, D; Houston, JB; Turlizzi, E; Zanelli, U1
Barber, S; Dew, TP; Farrell, TL; Poquet, L; Williamson, G1
Bellman, K; Knegtel, RM; Settimo, L1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL1
Kokubo, T; Morimoto, Y; Sugibayashi, K1
Hartenbach, EM; Hunter, VJ; Sammarco, MJ1
Eriksson, H; Korttila, K; Tenhunen, A1
Hsieh, JR; Hui, YL; Lau, WM; Ng, YT; Wang, YL; Yu, CC1
Faulkner, PM; Weary, DM1
Abbassi, O; al Harrar, R; Bouaggad, A; Bouderka, MA; Samkaoui, MA1
Crowe, MA; Earley, B1
Bruce, RA; Gregory, NG; Mellor, DJ; Stafford, KJ; Sutherland, MA; Ward, RN1
Bruce, RA; Mellor, DJ; Stafford, KJ; Todd, SE; Ward, RN1
Crowe, MA; Earley, B; Hughes, JM; Ting, ST1
Al-Harrar, R; Bouaggad, A; Bouderka, MA; Harti, A1
Dash, AK; Ganguly, S1
Arakawa, Y; Hashida, M; Kawakami, S; Yamashita, F1
Danjo, K; Okamoto, H; Sakai, T1
Al Kattan, K; Delvi, B; El-Dawlatly, AA; Essa, M; Hajjar, W; Khoja, A1
Fang, L; He, Z; Xu, Y; Zhao, L; Zhao, Y1
Fang, L; He, Z; Liu, S; Xu, Y; Zhao, L; Zhao, Y1
Api, M; Api, O; Emeksiz, MB; Ergen, B; Ugurel, V; Unal, O1
DeHaan, A; Duffield, TF; Heinrich, A; James, S; Lissemore, K; Millman, ST1
Michniak-Kohn, B; Zhang, J1
Ayoğlu, H; Erdoğan, G; Gül, Ş; Hanci, V; Kargi, E; Köksal, BG; Okyay, RD; Turan, IÖ; Yurtlu, S1
Eliav, E; Haribabu, PK; Heir, GM1
Janett, F; Steiner, A1
Cakir Gungor, A; Cosar, E; Gencer, M; Hacivelioglu, S; Koc, E; Kosar, S1
Açmaz, G; Aksoy, H; Aksoy, Ü; Albayrak, E; Özoğlu, N1
Galluzzi, KE; Stanos, SP1
Akdogan, A; Eroglu, A1
Benseñor, IM; Bikson, M; Boggio, PS; Brunoni, AR; Caumo, W; Cordeiro, Q; Guarienti, F; Lotufo, PA; Shiozawa, P1
Gądek, A; Liszka, H2
Karlinski, M; Kolacz, M; Trzebicki, J; Walerzak, K1
Acmaz, G; Aksoy, H; Başer, M; Bayraktar, E; Müderris, İİ; Yilmaz, MO1
Bhuiyan, AKMMH; Waters, LJ1
Du, G; Kang, L; Kathuria, H; Li, H; Ruan, X; Sun, Y1
Akbas, I; Cakir, Z; Kocak, AO; Kocak, MB1
Boetker, J; Bouropoulos, N; Eleftheriadis, GK; Fatouros, DG; Jacobsen, J; Monou, PK; Rantanen, J; Vizirianakis, IS1
Akbas, I; Akgol Gur, ST; Cakir, Z; Demir, M; Dogruyol, S; Dolanbay, T; Kocak, AO; Oral Ahiskalioglu, E1
Seyhan, AU; Yılmaz, E1
Ahiskalioglu, A; Ahiskalioglu, EO; Aydin, ME; Aydin, P; Gur, STA; Kocak, AO1

Reviews

3 review(s) available for ketoprofen and lidocaine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
[Castration in the bull calf and ram lamb].
    Schweizer Archiv fur Tierheilkunde, 2013, Volume: 155, Issue:11

    Topics: Administration, Intravenous; Age Factors; Anesthesia, Local; Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cattle; Contraception, Immunologic; Gonadotropin-Releasing Hormone; Ketoprofen; Lidocaine; Male; Orchiectomy; Sheep; Switzerland; Tetanus Toxoid; Vaccines, Contraceptive

2013
Topical therapies in the management of chronic pain.
    Postgraduate medicine, 2013, Volume: 125, Issue:4 Suppl 1

    Topics: Administration, Cutaneous; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Chronic Pain; Diclofenac; Humans; Ibuprofen; Irritants; Ketoprofen; Lidocaine; Musculoskeletal Pain; Neoplasms; Neuralgia; Neuralgia, Postherpetic; Osteoarthritis, Knee; Palliative Care

2013

Trials

21 trial(s) available for ketoprofen and lidocaine

ArticleYear
Local anesthesia for cryosurgery on the cervix.
    The Journal of reproductive medicine, 1993, Volume: 38, Issue:3

    Topics: Anesthesia, Local; Cervix Uteri; Colposcopy; Cryosurgery; Female; Humans; Injections, Subcutaneous; Ketoprofen; Lidocaine; Naproxen; Preanesthetic Medication; Prospective Studies; Uterine Cervical Dysplasia

1993
Balanced analgesia improves recovery and outcome after outpatient tubal ligation.
    Acta anaesthesiologica Scandinavica, 1996, Volume: 40, Issue:2

    Topics: Adult; Ambulatory Surgical Procedures; Analgesia; Anesthesia Recovery Period; Anesthetics, Local; Double-Blind Method; Female; Fentanyl; Humans; Ketoprofen; Laparoscopy; Lidocaine; Middle Aged; Pain Measurement; Pain, Postoperative; Sterilization, Tubal

1996
Local supplementation of ketoprofen reduces the incidence of low back pain after lumbar epidural anesthesia.
    Changgeng yi xue za zhi, 1999, Volume: 22, Issue:3

    Topics: Adult; Aged; Anesthesia, Epidural; Anti-Inflammatory Agents, Non-Steroidal; Back Pain; Female; Hemorrhoids; Humans; Incidence; Ketoprofen; Lidocaine; Male; Middle Aged

1999
[Addition of clonidine to 0.5% lidocaine for intravenous locoregional anesthesia].
    Annales francaises d'anesthesie et de reanimation, 2001, Volume: 20, Issue:3

    Topics: Adult; Analysis of Variance; Anesthesia, Intravenous; Anesthesia, Local; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Clonidine; Double-Blind Method; Drug Combinations; Female; Humans; Ketoprofen; Lidocaine; Male; Pain Measurement; Pain, Postoperative

2001
Cortisol responses to dehorning of calves given a 5-h local anaesthetic regimen plus phenylbutazone, ketoprofen, or adrenocorticotropic hormone prior to dehorning.
    Research in veterinary science, 2002, Volume: 73, Issue:2

    Topics: Adrenocorticotropic Hormone; Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bupivacaine; Cattle; Drug Interactions; Drug Therapy, Combination; Female; Horns; Hydrocortisone; Inflammation; Ketoprofen; Lidocaine; Male; Phenylbutazone; Stress, Physiological; Time Factors

2002
Effects of local anaesthesia or local anaesthesia plus a non-steroidal anti-inflammatory drug on the acute cortisol response of calves to five different methods of castration.
    Research in veterinary science, 2002, Volume: 73, Issue:1

    Topics: Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Cattle; Hydrocortisone; Ketoprofen; Lidocaine; Male; Orchiectomy; Pain; Stress, Physiological; Time Factors; Wound Healing

2002
[Neostigmine added to bupivacaine in axillary plexus block: which benefit?].
    Annales francaises d'anesthesie et de reanimation, 2003, Volume: 22, Issue:6

    Topics: Adult; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Bupivacaine; Female; Heart Rate; Humans; Ketoprofen; Lidocaine; Male; Middle Aged; Neostigmine; Nerve Block; Orthopedic Procedures; Pain Measurement; Pain, Postoperative; Parasympathomimetics; Postoperative Nausea and Vomiting; Surgery, Plastic

2003
Comparison of oral nonsteroidal analgesic and intrauterine local anesthetic for pain relief in uterine fractional curettage: a randomized, double-blind, placebo-controlled trial.
    American journal of obstetrics and gynecology, 2010, Volume: 203, Issue:1

    Topics: Administration, Intravaginal; Administration, Oral; Adult; Anesthesia, Local; Anesthesia, Obstetrical; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Curettage; Double-Blind Method; Female; Humans; Ketoprofen; Lidocaine; Middle Aged; Pain; Pain Measurement; Statistics, Nonparametric; Tromethamine

2010
Reduction in pain response by combined use of local lidocaine anesthesia and systemic ketoprofen in dairy calves dehorned by heat cauterization.
    The Canadian veterinary journal = La revue veterinaire canadienne, 2010, Volume: 51, Issue:3

    Topics: Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Cattle; Female; Horns; Hydrocortisone; Ketoprofen; Lidocaine; Pain, Postoperative; Time Factors; Treatment Outcome

2010
The analgesic effect of dexketoprofen when added to lidocaine for intravenous regional anaesthesia: a prospective, randomized, placebo-controlled study.
    The Journal of international medical research, 2011, Volume: 39, Issue:5

    Topics: Adult; Anesthesia Recovery Period; Anesthesia, Intravenous; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Arm; Blood Pressure; Double-Blind Method; Drug Combinations; Female; Hand; Heart Rate; Humans; Intraoperative Period; Ketoprofen; Lidocaine; Male; Middle Aged; Pain Measurement; Pain, Postoperative; Prospective Studies; Tromethamine

2011
Can the addition of a paracervical block to systemic or local analgesics improve the pain perceived by the patient during hysterosalpingography?
    Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology, 2014, Volume: 34, Issue:1

    Topics: Adolescent; Adult; Anesthesia, Local; Anesthesia, Obstetrical; Anesthetics, Local; Double-Blind Method; Female; Humans; Hysterosalpingography; Injections, Intramuscular; Ketoprofen; Lidocaine; Pain; Prospective Studies; Tromethamine; Young Adult

2014
Effect of paracetamol, dexketoprofen trometamol, lidocaine spray, and paracervical block application for pain relief during suction termination of first-trimester pregnancy.
    BioMed research international, 2013, Volume: 2013

    Topics: Abortion, Induced; Acetaminophen; Administration, Intravenous; Administration, Oral; Adult; Anesthesia, Obstetrical; Female; Humans; Ketoprofen; Lidocaine; Pain; Pregnancy; Pregnancy Trimester, First; Tromethamine

2013
Comparison of the effect of lidocaine adding dexketoprofen and paracetamol in intravenous regional anesthesia.
    BioMed research international, 2014, Volume: 2014

    Topics: Acetaminophen; Adult; Anesthesia, Conduction; Anesthesia, Intravenous; Female; Forearm; Humans; Ketoprofen; Lidocaine; Male; Pain Measurement; Tromethamine; Young Adult

2014
Reducing transcranial direct current stimulation-induced erythema with skin pretreatment: considerations for sham-controlled clinical trials.
    Neuromodulation : journal of the International Neuromodulation Society, 2015, Volume: 18, Issue:4

    Topics: Administration, Cutaneous; Adult; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Antipruritics; Erythema; Female; Healthy Volunteers; Humans; Hydroxyzine; Ketoprofen; Lidocaine; Male; Surveys and Questionnaires; Time Factors; Transcranial Direct Current Stimulation; Young Adult

2015
[Preemptive local anesthetic infiltration in hallux valgus one-day surgery].
    Przeglad lekarski, 2015, Volume: 72, Issue:1

    Topics: Acetaminophen; Ambulatory Surgical Procedures; Anesthesia, Local; Anesthetics, Local; Bupivacaine; Hallux Valgus; Humans; Ketoprofen; Lidocaine; Middle Aged; Pain Measurement; Pain, Postoperative; Premedication

2015
Preoperative Local Administration of Morphine as an Add-on Therapy in Patients Undergoing Surgical Removal of an Odontogenic Maxillary Cyst. A Randomized, Double-Blind Pilot Study.
    Journal of oral & facial pain and headache, 2015,Fall, Volume: 29, Issue:4

    Topics: Acetaminophen; Administration, Intravenous; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia, Dental; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Female; Humans; Ketoprofen; Lidocaine; Male; Maxillary Diseases; Middle Aged; Morphine; Odontogenic Cysts; Pain Measurement; Pain, Postoperative; Pilot Projects; Premedication; Safety; Tramadol; Treatment Outcome; Young Adult

2015
Effect of paracetamol, dexketoprofen trometamol, lidocaine spray, pethidine & diclofenac sodium application for pain relief during fractional curettage: A randomized controlled trial.
    The Indian journal of medical research, 2015, Volume: 142, Issue:4

    Topics: Acetaminophen; Adult; Aged; Analgesia; Curettage; Diclofenac; Female; Gynecologic Surgical Procedures; Humans; Ketoprofen; Lidocaine; Male; Meperidine; Middle Aged; Pain; Pain Management; Tromethamine; Uterine Hemorrhage

2015
Preemptive Local Anesthesia in Ankle Arthroscopy.
    Foot & ankle international, 2016, Volume: 37, Issue:12

    Topics: Adult; Anesthesia, General; Anesthesia, Local; Anesthesia, Spinal; Anesthetics, Local; Ankle; Anti-Inflammatory Agents, Non-Steroidal; Arthroscopy; Bupivacaine; Female; Humans; Injections; Ketoprofen; Lidocaine; Male; Pain Measurement; Pain, Postoperative

2016
Comparison of intradermal mesotherapy with systemic therapy in the treatment of low back pain: A prospective randomized study.
    The American journal of emergency medicine, 2020, Volume: 38, Issue:7

    Topics: Adult; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Colchicine; Emergency Service, Hospital; Female; Humans; Intervertebral Disc Displacement; Ketoprofen; Lidocaine; Low Back Pain; Male; Mesotherapy; Middle Aged; Piroxicam; Prospective Studies; Visual Analog Scale

2020
Lidocaine versus dexketoprofen in treatment of tension-type headache: A double-blind randomized controlled trial.
    The American journal of emergency medicine, 2021, Volume: 41

    Topics: Adult; Double-Blind Method; Female; Humans; Ketoprofen; Lidocaine; Male; Middle Aged; Prospective Studies; Tension-Type Headache; Tromethamine

2021
Intravenous lidocaine vs. NSAIDs for migraine attack in the ED: a prospective, randomized, double-blind study.
    European journal of clinical pharmacology, 2022, Volume: 78, Issue:1

    Topics: Adult; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Female; Humans; Infusions, Intravenous; Ketoprofen; Lidocaine; Male; Middle Aged; Migraine Disorders; Pain Measurement; Prospective Studies; Tromethamine

2022

Other Studies

42 other study(ies) available for ketoprofen and lidocaine

ArticleYear
Prediction of drug solubility from Monte Carlo simulations.
    Bioorganic & medicinal chemistry letters, 2000, Jun-05, Volume: 10, Issue:11

    Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility

2000
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Cheminformatic models to predict binding affinities to human serum albumin.
    Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25

    Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids

2001
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability.
    Journal of medicinal chemistry, 2004, Mar-25, Volume: 47, Issue:7

    Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties

2004
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
    Journal of medicinal chemistry, 2005, May-05, Volume: 48, Issue:9

    Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water

2005
Parallel artificial membrane permeability assay: a new membrane for the fast prediction of passive human skin permeability.
    Journal of medicinal chemistry, 2006, Jun-29, Volume: 49, Issue:13

    Topics: 1-Octanol; Diffusion; Dimethylpolysiloxanes; Humans; In Vitro Techniques; Membranes, Artificial; Myristates; Permeability; Skin; Skin Absorption; Water

2006
In silico and in vitro filters for the fast estimation of skin permeation and distribution of new chemical entities.
    Journal of medicinal chemistry, 2007, Feb-22, Volume: 50, Issue:4

    Topics: Humans; Membranes, Artificial; Models, Biological; Models, Molecular; Octanols; Permeability; Pharmaceutical Preparations; Skin Absorption; Water

2007
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds.
    Bioorganic & medicinal chemistry, 2007, Nov-15, Volume: 15, Issue:22

    Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption

2007
Molecular characteristics for solid-state limited solubility.
    Journal of medicinal chemistry, 2008, May-22, Volume: 51, Issue:10

    Topics: Chemical Phenomena; Chemistry, Physical; Molecular Structure; Multivariate Analysis; Pharmaceutical Preparations; Regression Analysis; Solubility

2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:4

    Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software

2009
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:11

    Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution

2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
    Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19

    Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship

2009
Development of an in silico model for human skin permeation based on a Franz cell skin permeability assay.
    Bioorganic & medicinal chemistry letters, 2010, Jan-01, Volume: 20, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Cell Line; Cell Membrane Permeability; Humans; Models, Biological; Quantitative Structure-Activity Relationship; Skin Absorption

2010
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
QSAR-based solubility model for drug-like compounds.
    Bioorganic & medicinal chemistry, 2010, Oct-01, Volume: 18, Issue:19

    Topics: Databases, Factual; Models, Molecular; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Solubility; Water

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
QSAR-based permeability model for drug-like compounds.
    Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8

    Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2011
Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1

    Topics: Cell Line, Tumor; Cryopreservation; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Predictive Value of Tests

2012
Predicting phenolic acid absorption in Caco-2 cells: a theoretical permeability model and mechanistic study.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:2

    Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Cinnamates; Enterocytes; Humans; Hydrophobic and Hydrophilic Interactions; Intestinal Absorption; Kinetics; Models, Biological; Molecular Conformation; Osmolar Concentration; Phenols

2012
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
    Pharmaceutical research, 2014, Volume: 31, Issue:4

    Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation

2014
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
    PloS one, 2016, Volume: 11, Issue:10

    Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat

2016
Interaction between drugs and pressure-sensitive adhesives in transdermal therapeutic systems.
    Pharmaceutical research, 1994, Volume: 11, Issue:1

    Topics: Acrylates; Adhesives; Administration, Cutaneous; Aminopyrine; Calorimetry, Differential Scanning; Diffusion; Ketoprofen; Lidocaine; Pharmaceutical Preparations; Rubber; Silicones; Solubility

1994
Reducing pain after dehorning in dairy calves.
    Journal of dairy science, 2000, Volume: 83, Issue:9

    Topics: Anesthesia, Local; Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Cattle; Female; Horns; Hypnotics and Sedatives; Ketoprofen; Lidocaine; Male; Pain, Postoperative; Time Factors; Xylazine

2000
Effects of ketoprofen alone or in combination with local anesthesia during the castration of bull calves on plasma cortisol, immunological, and inflammatory responses.
    Journal of animal science, 2002, Volume: 80, Issue:4

    Topics: Acute-Phase Proteins; Acute-Phase Reaction; Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cattle; Eating; Fibrinogen; Haptoglobins; Hydrocortisone; Interferon-gamma; Ketoprofen; Lidocaine; Male; Orchiectomy; Random Allocation; Weight Gain

2002
Effect of ketoprofen, lidocaine local anesthesia, and combined xylazine and lidocaine caudal epidural anesthesia during castration of beef cattle on stress responses, immunity, growth, and behavior.
    Journal of animal science, 2003, Volume: 81, Issue:5

    Topics: Acute-Phase Proteins; Acute-Phase Reaction; Anesthesia, Caudal; Anesthesia, Local; Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Cattle; Hydrocortisone; Interferon-gamma; Ketoprofen; Lidocaine; Male; Orchiectomy; Random Allocation; Stress, Physiological; Xylazine

2003
A novel in situ gel for sustained drug delivery and targeting.
    International journal of pharmaceutics, 2004, May-19, Volume: 276, Issue:1-2

    Topics: Anesthetics, Local; Antifungal Agents; Biocompatible Materials; Chemistry, Pharmaceutical; Chitin; Chitosan; Cross-Linking Reagents; Dexamethasone; Drug Delivery Systems; Gels; Glutaral; Glycerol; Ketoprofen; Lidocaine; Microspheres

2004
Effect of low-molecular-weight beta-cyclodextrin polymer on release of drugs from mucoadhesive buccal film dosage forms.
    Biological & pharmaceutical bulletin, 2005, Volume: 28, Issue:9

    Topics: Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; beta-Cyclodextrins; Calorimetry, Differential Scanning; Chemical Phenomena; Chemistry, Physical; Dosage Forms; Excipients; Fluorescent Dyes; Ketoprofen; Lidocaine; Lipids; Tissue Adhesives; Ultrafiltration

2005
Effect of sucrose fatty acid esters on transdermal permeation of lidocaine and ketoprofen.
    Biological & pharmaceutical bulletin, 2005, Volume: 28, Issue:9

    Topics: Administration, Cutaneous; Anesthetics, Local; Animals; Esters; Fatty Acids; In Vitro Techniques; Ketoprofen; Lidocaine; Mice; Mice, Hairless; Pharmaceutical Solutions; Pharmaceutical Vehicles; Skin Absorption; Sucrose

2005
Anesthetic implications for video assisted thoracoscopic thymectomy in myasthenia gravis.
    Middle East journal of anaesthesiology, 2005, Volume: 18, Issue:2

    Topics: Adult; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Bupivacaine; Female; Fentanyl; Humans; Intubation, Intratracheal; Ketoprofen; Lidocaine; Methyl Ethers; Monitoring, Intraoperative; Myasthenia Gravis; Propofol; Respiration, Artificial; Sevoflurane; Sufentanil; Thoracic Surgery, Video-Assisted; Thymectomy

2005
Effect of O-acylmenthol on transdermal delivery of drugs with different lipophilicity.
    International journal of pharmaceutics, 2008, Mar-20, Volume: 352, Issue:1-2

    Topics: Acids, Carbocyclic; Administration, Cutaneous; Animals; Chemistry, Pharmaceutical; Cinnamates; Diffusion Chambers, Culture; Drug Compounding; Fluorouracil; Hydrolysis; Indomethacin; Isosorbide Dinitrate; Ketoprofen; Kinetics; Lactates; Lidocaine; Male; Menthol; Oleic Acids; Permeability; Pharmaceutical Preparations; Rats; Rats, Wistar; Salicylates; Skin; Skin Absorption; Technology, Pharmaceutical

2008
Transdermal delivery of penetrants with differing lipophilicities using O-acylmenthol derivatives as penetration enhancers.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2008, Volume: 69, Issue:1

    Topics: Administration, Cutaneous; Animals; Chemistry, Pharmaceutical; Fatty Acids; Fluorouracil; Indomethacin; Isosorbide Dinitrate; Ketoprofen; Lidocaine; Male; Menthol; Rats; Rats, Wistar; Skin Absorption; Technology, Pharmaceutical

2008
Investigation of microemulsion microstructures and their relationship to transdermal permeation of model drugs: ketoprofen, lidocaine, and caffeine.
    International journal of pharmaceutics, 2011, Dec-12, Volume: 421, Issue:1

    Topics: Administration, Cutaneous; Animals; Azepines; Caffeine; Calorimetry, Differential Scanning; Electric Conductivity; Emulsions; Glycerides; Glycerol; Hydrophobic and Hydrophilic Interactions; In Vitro Techniques; Ketoprofen; Lidocaine; Myristates; Organic Chemicals; Permeability; Skin; Sulfur Compounds; Surface-Active Agents; Swine; Water

2011
Topical medications for the effective management of neuropathic orofacial pain.
    Journal of the American Dental Association (1939), 2013, Volume: 144, Issue:6

    Topics: Administration, Topical; Amines; Analgesics, Non-Narcotic; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Carbamazepine; Cranial Nerve Diseases; Cyclohexanecarboxylic Acids; Diagnosis, Differential; Facial Pain; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Hyperesthesia; Iatrogenic Disease; Ketoprofen; Lidocaine; Maxillary Nerve; Middle Aged; Neuralgia; Radicular Cyst

2013
Ionisation effects on the permeation of pharmaceutical compounds through silicone membrane.
    Colloids and surfaces. B, Biointerfaces, 2016, May-01, Volume: 141

    Topics: Benzoic Acid; Chemistry, Pharmaceutical; Chromatography, Gas; Hydrogen-Ion Concentration; Ibuprofen; Ions; Ketoprofen; Lidocaine; Membranes, Artificial; Permeability; Pharmaceutical Preparations; Silicon; Surface Properties; Triazoles

2016
Fabrication of non-dissolving analgesic suppositories using 3D printed moulds.
    International journal of pharmaceutics, 2016, Nov-20, Volume: 513, Issue:1-2

    Topics: Analgesics; Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Chemistry, Pharmaceutical; Delayed-Action Preparations; Diclofenac; Drug Liberation; Elastic Modulus; Ibuprofen; Ketoprofen; Lidocaine; Mice; Printing, Three-Dimensional; Silicone Elastomers; Solubility; Suppositories; Tensile Strength

2016
Fabrication of Mucoadhesive Buccal Films for Local Administration of Ketoprofen and Lidocaine Hydrochloride by Combining Fused Deposition Modeling and Inkjet Printing.
    Journal of pharmaceutical sciences, 2020, Volume: 109, Issue:9

    Topics: Adhesiveness; Administration, Buccal; Animals; Drug Delivery Systems; Humans; Hypromellose Derivatives; Ketoprofen; Lidocaine; Mouth Mucosa; Swine

2020
Treatment of Renal Colic by Nerve Blockade with Lidocaine Versus Intravenous Dexketoprofen.
    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2021, Volume: 31, Issue:8

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Emergency Service, Hospital; Female; Humans; Ketoprofen; Lidocaine; Male; Nerve Block; Renal Colic; Tromethamine; Turkey

2021