ketoprofen and ketorolac

ketoprofen has been researched along with ketorolac in 31 studies

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (19.35)18.2507
2000's10 (32.26)29.6817
2010's14 (45.16)24.3611
2020's1 (3.23)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Anacardio, R; Aureli, L; Cesta, MC; Cruciani, G; De Simone, L; Moriconi, A1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y1
Lombardo, F; Obach, RS; Waters, NJ1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Campillo, NE; Guerra, A; Páez, JA1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Bellera, CL; Bruno-Blanch, LE; Castro, EA; Duchowicz, PR; Goodarzi, M; Ortiz, EV; Pesce, G; Talevi, A1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K1
Kumar, M; Sinha, VR; Thareja, S1
Buckley, DB; Funk, RS; Hensley, T; Kazmi, F; Loewen, GJ; Parkinson, A; Pope, C1
Bellman, K; Knegtel, RM; Settimo, L1
Headey, SJ; Hughes, ML; Laguerre, A; Mohanty, B; Patil, R; Porter, CJ; Scanlon, MJ; Wielens, J; Williams, ML1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Jones, TA; Nakagawa, A; Smith, CE; Soti, S; Xue, D; Yin, H1
Accorra, F; Della Ventura, M; Dordoni, PL; Iannace, E; Paparella, P; Rocca, B; Stefanelli, A1
Cabré, F; Carabaza, A; García, ML; Gómez, M; Gutiérrez, M; Mauleón, D; Rotllan, E1
Niemi, TT; Rosenberg, PH; Taxell, C1
Hendolin, H; Kokki, H; Kostamovaara, PA; Nuutinen, LS1
Cabré, F; Díaz, I; Fernández-Guasti, A; López-Muñoz, FJ; Mauleón, D; Tost, D; Ventura, R1
Saarnivaara, L; Tarkkila, P1
Gálvez, R; Olmedo, MV; Vallecillo, M1
Abdalla, M; Bianchi, PG; Bonnet, F; Camu, F; Ebrahim, S; Escolar, G; Forrest, JB; Greer, IA; Heitlinger, E; Jage, J; Kehlet, H; Langman, MJ; Pocock, S; Samama, MM; Velo, G1
Aramberry, L; Cesolari, JA; Godoy, A; Laudanno, OM; Piombo, G; Rocaspana, A1
Busquets, C; Camba, MA; Castro, A; Contreras, D; Gálvez, R; Herrera, J; Rodríguez, MJ1
Unlü, B; van Leeuwen, JS; Vermeulen, NP; Vos, JC1
De Luna-Bertos, E; García-Martínez, O; Guildford, A; Ramos-Torrecillas, J; Ruiz, C; Santin, M1
De Luna-Bertos, E; García-Martínez, O; Manzano-Moreno, FJ; Ramos-Torrecillas, J; Ruiz, C1
Aranda, N; Miranda, HF; Noriega, V; Poblete, P; Prieto, JC; Sierralta, F1
Gorenflo, M; Saur, P; van den Anker, JN; van Dyk, M; Welzel, T; Ziesenitz, VC1

Reviews

2 review(s) available for ketoprofen and ketorolac

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Efficacy and Safety of NSAIDs in Infants: A Comprehensive Review of the Literature of the Past 20 Years.
    Paediatric drugs, 2022, Volume: 24, Issue:6

    Topics: Adolescent; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Child; Chronic Disease; Diclofenac; Flurbiprofen; Humans; Ibuprofen; Infant; Ketoprofen; Ketorolac; Meloxicam; Naproxen; Niflumic Acid; Pain

2022

Trials

7 trial(s) available for ketoprofen and ketorolac

ArticleYear
Effect of ketorolac, ketoprofen and nefopam on platelet function.
    Anaesthesia, 1994, Volume: 49, Issue:12

    Topics: Bleeding Time; Blood Platelets; Cells, Cultured; Female; Humans; Ketoprofen; Ketorolac; Nefopam; Platelet Aggregation; Platelet Aggregation Inhibitors; Tolmetin

1994
Comparison of the effect of intravenous ketoprofen, ketorolac and diclofenac on platelet function in volunteers.
    Acta anaesthesiologica Scandinavica, 1997, Volume: 41, Issue:10

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Blood Platelets; Cross-Over Studies; Diclofenac; Double-Blind Method; Humans; Ketoprofen; Ketorolac; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Tolmetin

1997
Ketorolac, diclofenac and ketoprofen are equally efficacious for pain relief after total hip replacement surgery.
    British journal of anaesthesia, 1998, Volume: 81, Issue:3

    Topics: Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia, Spinal; Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replacement, Hip; Cyclooxygenase Inhibitors; Diclofenac; Double-Blind Method; Drug Administration Schedule; Female; Fentanyl; Humans; Ketoprofen; Ketorolac; Male; Middle Aged; Pain, Postoperative; Prospective Studies; Tolmetin

1998
Ketoprofen, diclofenac or ketorolac for pain after tonsillectomy in adults?
    British journal of anaesthesia, 1999, Volume: 82, Issue:1

    Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Diclofenac; Double-Blind Method; Female; Humans; Ketoprofen; Ketorolac; Male; Middle Aged; Pain Measurement; Pain, Postoperative; Patient Satisfaction; Tolmetin; Tonsillectomy

1999
Double-blind parallel comparison of multiple doses of ketorolac, ketoprofen and placebo administered orally to patients with postoperative dental pain.
    Pain, 2001, Feb-01, Volume: 90, Issue:1-2

    Topics: Administration, Oral; Adolescent; Adult; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Chi-Square Distribution; Double-Blind Method; Female; Humans; Ketoprofen; Ketorolac; Linear Models; Logistic Models; Male; Molar, Third; Multivariate Analysis; Pain Measurement; Pain, Postoperative; Placebo Effect; Placebos

2001
Ketorolac, diclofenac, and ketoprofen are equally safe for pain relief after major surgery.
    British journal of anaesthesia, 2002, Volume: 88, Issue:2

    Topics: Acute Kidney Injury; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Blood Loss, Surgical; Cyclooxygenase Inhibitors; Diclofenac; Drug Hypersensitivity; Female; Humans; Ketoprofen; Ketorolac; Male; Middle Aged; Pain, Postoperative; Prospective Studies; Risk Factors

2002
Double-blind evaluation of short-term analgesic efficacy of orally administered dexketoprofen trometamol and ketorolac in bone cancer pain.
    Pain, 2003, Volume: 104, Issue:1-2

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Bone Neoplasms; Chi-Square Distribution; Double-Blind Method; Female; Humans; Ketoprofen; Ketorolac; Male; Middle Aged; Pain; Statistics, Nonparametric; Tromethamine

2003

Other Studies

22 other study(ies) available for ketoprofen and ketorolac

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Predicting human serum albumin affinity of interleukin-8 (CXCL8) inhibitors by 3D-QSPR approach.
    Journal of medicinal chemistry, 2005, Apr-07, Volume: 48, Issue:7

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Chemical Phenomena; Chemistry, Physical; Humans; In Vitro Techniques; Interleukin-8; Models, Molecular; Phenylpropionates; Protein Binding; Quantitative Structure-Activity Relationship; Serum Albumin; Stereoisomerism

2005
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds.
    Bioorganic & medicinal chemistry, 2007, Nov-15, Volume: 15, Issue:22

    Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption

2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:3

    Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical

2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Prediction of drug intestinal absorption by new linear and non-linear QSPR.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:1

    Topics: Humans; Intestinal Absorption; Linear Models; Molecular Conformation; Nonlinear Dynamics; Permeability; Pharmaceutical Preparations; Probability; Quantitative Structure-Activity Relationship; Thermodynamics

2011
QSAR-based permeability model for drug-like compounds.
    Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8

    Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2011
Self-organizing molecular field analysis of NSAIDs: assessment of pharmacokinetic and physicochemical properties using 3D-QSPkR approach.
    European journal of medicinal chemistry, 2012, Volume: 53

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemical Phenomena; Computational Biology; Least-Squares Analysis; Models, Molecular; Molecular Conformation; Quantitative Structure-Activity Relationship

2012
Lysosomal sequestration (trapping) of lipophilic amine (cationic amphiphilic) drugs in immortalized human hepatocytes (Fa2N-4 cells).
    Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:4

    Topics: Adrenergic beta-Antagonists; Amines; Ammonium Chloride; Antidepressive Agents, Tricyclic; Atorvastatin; Cell Line, Transformed; Diuretics; Hepatocytes; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imipramine; Lysosomes; Monensin; Nigericin; Propranolol; Pyrroles

2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
    Pharmaceutical research, 2014, Volume: 31, Issue:4

    Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation

2014
Characterization of two distinct modes of drug binding to human intestinal fatty acid binding protein.
    ACS chemical biology, 2014, Nov-21, Volume: 9, Issue:11

    Topics: Fatty Acid-Binding Proteins; Fluorescent Dyes; Humans; Nuclear Magnetic Resonance, Biomolecular; Protein Binding; Spectrometry, Fluorescence

2014
Non-steroidal Anti-inflammatory Drugs Are Caspase Inhibitors.
    Cell chemical biology, 2017, Mar-16, Volume: 24, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Caspase Inhibitors; Caspases; Caspases, Initiator; Cell Line; Cell Survival; High-Throughput Screening Assays; Humans; Ibuprofen; Inhibitory Concentration 50; Ketorolac; Naproxen; Small Molecule Libraries; Substrate Specificity

2017
Stereoselective inhibition of inducible cyclooxygenase by chiral nonsteroidal antiinflammatory drugs.
    Journal of clinical pharmacology, 1996, Volume: 36, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Female; Flurbiprofen; Guinea Pigs; Humans; Isoenzymes; Ketoprofen; Ketorolac; Male; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Sheep; Stereoisomerism; Tolmetin

1996
Antinociceptive effects of S(+)-ketoprofen and other analgesic drugs in a rat model of pain induced by uric acid.
    Journal of clinical pharmacology, 1998, Volume: 38, Issue:S1

    Topics: Administration, Oral; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Biotransformation; Disease Models, Animal; Dose-Response Relationship, Drug; Flurbiprofen; Injections, Intraventricular; Ketoprofen; Ketorolac; Male; Morphine; Pain; Rats; Rats, Sprague-Dawley; Rats, Wistar; Stereoisomerism; Tolmetin; Tromethamine; Uric Acid

1998
[Dexketoprofene, selective cox-1 inhibitor nsaids, without gastrointestinal injury in rats].
    Acta gastroenterologica Latinoamericana, 2002, Volume: 32, Issue:1

    Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase Inhibitors; Drug Evaluation, Preclinical; Gastric Mucosa; Humans; Intestinal Mucosa; Ketoprofen; Ketorolac; Pyrazoles; Rats; Rats, Wistar; Sulfonamides; Tromethamine

2002
Differential involvement of mitochondrial dysfunction, cytochrome P450 activity, and active transport in the toxicity of structurally related NSAIDs.
    Toxicology in vitro : an international journal published in association with BIBRA, 2012, Volume: 26, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; ATP-Binding Cassette Transporters; Biological Transport, Active; Cytochrome P-450 Enzyme System; Diclofenac; Electron Transport; Genes, MDR; Ibuprofen; Indomethacin; Ketoprofen; Ketorolac; Mitochondria; Naproxen; Reactive Oxygen Species; Sulindac; Tolmetin; Yeasts

2012
Therapeutic doses of nonsteroidal anti-inflammatory drugs inhibit osteosarcoma MG-63 osteoblast-like cells maturation, viability, and biomineralization potential.
    TheScientificWorldJournal, 2013, Volume: 2013

    Topics: Alkaline Phosphatase; Anti-Inflammatory Agents, Non-Steroidal; Antigens, Differentiation; Aspirin; Bone Neoplasms; Bone Remodeling; Calcification, Physiologic; Cell Differentiation; Cell Line, Tumor; Cell Survival; Collagen; Culture Media; Dipyrone; Extracellular Matrix; Flow Cytometry; Humans; Ketoprofen; Ketorolac; Minerals; Osteoblasts; Osteosarcoma; Phagocytosis; Tromethamine

2013
Effects on growth of human osteoblast-like cells of three nonsteroidal anti-inflammatory drugs: metamizole, dexketoprofen, and ketorolac.
    Biological research for nursing, 2015, Volume: 17, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Cycle; Cell Line; Cell Proliferation; Dipyrone; Dose-Response Relationship, Drug; Humans; Ketoprofen; Ketorolac; Osteoblasts

2015
Nitric Oxide and Opioids Involvement in Isobolographic Nsaids Antinociception.
    Drug research, 2019, Volume: 69, Issue:12

    Topics: Acetaminophen; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Ibuprofen; Ketoprofen; Ketorolac; Mice; Nitric Oxide; Pain; Pain Measurement

2019