ketoprofen has been researched along with indomethacin in 234 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 93 (39.74) | 18.7374 |
| 1990's | 38 (16.24) | 18.2507 |
| 2000's | 58 (24.79) | 29.6817 |
| 2010's | 41 (17.52) | 24.3611 |
| 2020's | 4 (1.71) | 2.80 |
| Authors | Studies |
|---|---|
| Allegretti, M; Aramini, A; Aschi, M; Bertini, R; Bizzarri, C; Cesta, MC; Crucianelli, M; Di Bitondo, R; Di Giacinto, C; Gloaguen, I; Moriconi, A; Sablone, MR | 1 |
| Kubo, S; Tagawa, H; Tsukada, W; Ueno, K; Yoshioka, T | 1 |
| Cerelli, MJ; Curtis, DL; Dunn, JP; Nelson, PH; Peak, TM; Waterbury, LD | 1 |
| Bundgaard, H; Nielsen, NM | 1 |
| Behn, DC; Botton, I; Fellows, CA; Laskowski, SC; Phillips, DK; Schlegel, DC; Speight, PT; Zenitz, BL | 1 |
| Inui, KI; Masuda, S; Saito, H | 1 |
| Apiwattanakul, N; Chairoungdua, A; Endou, H; Kanai, Y; Nakajima, N; Sekine, T; Sophasan, S | 1 |
| Strassburg, CP; Tukey, RH | 1 |
| Duffy, EM; Jorgensen, WL | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Cihlar, T; Ho, ES; Mulato, AS | 1 |
| Inui, K; Saito, H; Uwai, Y | 1 |
| Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL | 1 |
| Abe, T; Itoh, T; Kato, Y; Kusuhara, H; Meier, PJ; Shitara, Y; Sugiyama, D; Sugiyama, Y | 1 |
| Cha, SH; Endou, H; Hosoyamada, M; Khamdang, S; Kimura, H; Narikawa, S; Sekine, T; Takeda, M | 1 |
| Borst, P; de Haas, M; Kuil, A; Reid, G; van der Heijden, I; Wielinga, P; Wijnholds, J; Zelcer, N | 1 |
| Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P | 1 |
| Charitos, C; Doulgkeris, C; Galanakis, D; Gavalas, A; Kourounakis, AP; Kourounakis, PN; Kravaritou, C; Rekka, EA; Tsiakitzis, KC | 1 |
| Beroza, P; Cai, D; Damodaran, K; Gomez, RF; Hsu, N; Keck, JG; Laborde, E; Lum, RT; Macke, TJ; Martin, G; Schow, SR; Simon, RJ; Villar, HO; Wick, MM | 1 |
| Chang, TK; Ensom, MH; Kiang, TK | 1 |
| Anacardio, R; Aureli, L; Cesta, MC; Cruciani, G; De Simone, L; Moriconi, A | 1 |
| Caron, G; Ermondi, G | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Carrupt, PA; Martel, S; Ottaviani, G | 2 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Beydemir, S; Ekinci, D | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
| Conradi, R; Lee, PH; Shanmugasundaram, V | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Avdeef, A; Tam, KY | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Buttar, D; Colclough, N; Gerhardt, S; MacFaul, PA; Maskos, K; Phillips, SD; Plowright, A; Steinbacher, S; Steuber, H; Tam, K; Whittamore, P | 1 |
| Fujiwara, R; Koga, T; Nakajima, M; Yokoi, T | 1 |
| Bellera, CL; Bruno-Blanch, LE; Castro, EA; Duchowicz, PR; Goodarzi, M; Ortiz, EV; Pesce, G; Talevi, A | 1 |
| Bu, X; Cao, Y; Hu, X; Luo, M; Ren, Y; Song, Y; Wang, X; Xu, Q; Yuan, M | 1 |
| Deguchi, T; Furuta, Y; Fusegawa, K; Hirouchi, M; Igeta, K; Ikenaga, H; Iwasaki, M; Izumi, T; Kurihara, A; Murata, S; Okazaki, O; Suzuki, N; Watanabe, N | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Cheng, YK; Hu, X; Li, Z; Liu, M; Luo, HB; Yuan, M | 1 |
| Kumar, M; Sinha, VR; Thareja, S | 1 |
| Ambrosi, G; Bauer, J; Elkady, M; Laufer, SA; Luderer, S; Nieß, R; Schaible, AM; Werz, O | 1 |
| Capim, SL; Dos Santos, GC; Gonçalves, GM; Marinho, BG; Vasconcellos, ML | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Brewster, C; Deering-Rice, CE; Reilly, CA; Rose, TM | 1 |
| Alcaraz, B; Bratoeff, E; Cabeza, M; Camacho-Arroyo, I; Garrido, M; González-Arenas, A | 1 |
| Beaumont, K; Di, L; Maurer, TS; Smith, DA | 1 |
| Blair, A; Boyd, M; Chalmers, AJ; Malviya, G; Pimlott, SL; Sutherland, A; Zmuda, F | 1 |
| Chen, T; Guan, J; Liao, J; Luo, J; Qin, X; Talley, JJ; Tortorella, MD; Tu, Z; Zhang, Y | 1 |
| Kourounakis, PN; Kourti, M; Rekka, EA; Theodosis-Nobelos, P; Tziona, P | 1 |
| Gavalas, A; Kourti, M; Rekka, EA; Theodosis-Nobelos, P | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL | 1 |
| Boixareu, N; Campanera, JM; Navarro, L; Pors, K; Pouplana, R; Pujol, MD; Rosell, G; Sánchez, S | 1 |
| Ding, F; Gao, Y; He, X; Lei, Y; Li, S; Li, X; Li, Y; Li, Z; Wen, D; Zhang, Y; Zhong, M | 1 |
| Chang, G; Mathialagan, S; Ryu, S; Varma, MVS; Woody, N | 1 |
| Anderson, JA; Buchanan, WW; Lee, P; Miller, J; Webb, J | 1 |
| Boyle, E; Freeman, PC; Goudie, AC; Mangan, FR; Thomson, M | 1 |
| Huskisson, EC | 1 |
| Akimoto, T; Saito, T; Tachizawa, H; Tsukada, W | 1 |
| Fava, G; Galli, L; Liverta, C; Pollini, C; Pontiroli, AE; Vicari, A | 1 |
| Reinicke, C | 1 |
| Bhettay, E; Thomson, AJ | 1 |
| Grahame, R | 2 |
| Bloch, M; Gibson, T; Grahame, R; Griffin, AJ | 1 |
| Burdeĭnyĭ, AP | 1 |
| Franchi, R; Liverta, C; Pollini, C; Pontiroli, AE | 1 |
| Greco, P; Imbimbo, N; Lanzara, U; Lotti, G | 1 |
| Lee, MR; Littlewood, JM; Meadow, SR | 1 |
| Gross, W | 1 |
| Spisani, S; Traniello, S; Vanzini, G | 1 |
| Kawamoto, H; Komatsu, H; Kubota, T; Yamada, T | 1 |
| Blanchard, JC; Schneider, YJ; Trouet, A; Tulkens, P | 1 |
| Kauppila, A; Puolakka, J; Ylikorkala, O | 1 |
| Mörsdorf, K; Wolf, G | 1 |
| Peltola, P | 2 |
| Nagai, T; Nambu, N; Shimoda, M; Takahashi, Y; Ueda, H | 1 |
| Dale, I; Sjaastad, O | 1 |
| Franchi, R; Liverta, C; Pollini, C; Pontiroli, AE; Viara, M | 1 |
| Burry, HC; Grahame, R | 1 |
| Mason, M; Zutshi, D | 1 |
| Fossgreen, J; Kirchheiner, B; Petersen, FO; Tophoj, E; Zachariae, E | 1 |
| El-Ghobarey, AF; Hadidi, T; Hamid, HA; Mavrikakis, M; Rennie, JA | 1 |
| Fossgreen, J; Kirchheiner, B; Tophoj, E; Zachariae, E | 1 |
| Digby, JW; Wehner, S | 1 |
| Kitchen, EA; Meacock, SC | 1 |
| Guyonnet, JC; Julou, L | 1 |
| Ducrot, R; Guyonnet, JC; Julou, L; Pasquet, J | 1 |
| Binns, TB; Brooks, PM; Buchanan, WW; Mason, DI | 1 |
| Donovan, BT | 1 |
| Remans, J | 1 |
| Janssen, PA; Niemegeers, CJ; Van Bruggen, JA | 1 |
| Awouters, F; Janssen, PA; Lenaerts, PM; Niemegeers, CJ | 1 |
| Awouters, F; Janssen, PA; Lenaerts, FM; Niemegeers, CJ | 1 |
| Giudicelli, CP; Hirbec, G; Lagrue, G; Masbernard, A | 1 |
| Adams, RF; Barber, J; Barth, WF; Callahan, LF; Gordon, GV; Huston, JW; Marcum, SB; Pincus, T; Polk, JR; Whelton, JC | 1 |
| Cheymol, G; Lebot, M; Poirier, JM | 1 |
| Louisot, P; Mathieu, P; Richard, M; Vignon, E | 1 |
| Dolan, PW; Malone, DG; Seebruch, JS; Verbsky, JW; Vikingsson, A | 1 |
| Collier, S; Ghosh, P | 2 |
| Casady, RL; Itoh, T; Magavi, R; Nishihata, T; Rytting, JH | 1 |
| Blomgren, H; Hammarström, S; Petrini, B; Rotstein, S; Wasserman, J | 1 |
| Bergström, M; Carlsson, J; Csòka, K; Gàti, I; Muhr, C; Westerberg, G | 1 |
| Chang, JY; Elwell, JM; Goldring, MB; Sohbat, E | 1 |
| Haddad, J; Messer, J; Simeoni, U; Weisburd, P; Willard, D | 1 |
| Kawakubo, H; Matsumoto, K; Nishikawa, K; Suehiro, S; Toyomaki, Y; Yago, H | 1 |
| Hurault de Ligny, B; Ryckelynck, JP | 1 |
| Paulus, HE; Schlegel, SI | 1 |
| Giroud, JP; Molinie, B; Roch-Arveiller, M; Terlain, B; Vannier, E | 1 |
| Anderson, SA; Brater, DC; Brown-Cartwright, D; Toto, RD | 1 |
| Altman, RD; Honig, S; Levin, JM; Lightfoot, RW | 1 |
| Caldwell, JR; Germain, BF; Lourie, SH; McLaughlin, GE; Poiley, JE; Vreede, PD; Wilson, CH | 1 |
| Keller, F; Krause, PH; Mihatsch, MJ; Offermann, G; Schwarz, A | 1 |
| Sallmann, AR | 1 |
| Fujii, M; Matsumoto, M; Mori, T; Sawada, Y; Terai, H | 1 |
| Akitoshi, Y; Machida, Y; Nagai, T; Takayama, K | 1 |
| Collins, AJ; Davies, J; Dixon, AS | 1 |
| Kaushal, R; Tripathi, RM | 1 |
| Cremades, A; Garcia, F; Garcia-Peñarrubia, P; Sánchez Rincón, I | 1 |
| Anderson, SA; Brater, DC; Brown-Cartwright, D; Kokko, JP; Toto, RD | 1 |
| Bassi, GP; Borghi, C; Camarri, E; Cocco, F; Francucci, BM; Giannini, R; Giordano, N; Marcolongo, R; Mordini, M; Neri, D | 1 |
| Furio, M; Maggi, CA; Meli, A; Santicioli, P | 1 |
| Bird, J; Giroud, JP; Tissot, M | 1 |
| Brater, DC; Pak, CY; Rocco, VK; Sakhaee, K | 1 |
| Jelić-Ivanović, Z; Majkić-Singh, N; Spasić, S; Todorović, P | 1 |
| Kulkarni, PS; Srinivasan, BD | 1 |
| Machtey, I | 1 |
| Barkay, J; Ben-Ezra, S; Gordon, S; Harpaz-Kerpel, S; Zuckerman, H | 1 |
| Chakravarty, N | 1 |
| Kunz, S; Migne, J; Santonja, R | 1 |
| Bourat, G; Fournel, J; Heusse, D; Migne, J; Vedrine, Y | 1 |
| Rampon, S | 1 |
| Gougeon, J | 1 |
| Ibba, G; Perpignano, G; Uras, R | 1 |
| Ward, JR | 1 |
| Bizios, R; Malik, AB; Minnear, FL; van der Zee, H | 1 |
| Okpako, DT; Taiwo, YO | 1 |
| Evangelista, S; Giolitti, A; Grimaldi, G; Maggi, CA; Meli, A; Santicioli, P | 1 |
| Court, H; Volans, GN | 1 |
| Isomäki, H; Kaarela, K; Kajander, A; Koota, K; Lehtinen, K; Luukkainen, R; Martio, J; Martio, T; Nissilä, M; Nuotio, P | 1 |
| Radmanović, BZ; Sćepović, Z | 1 |
| Fujimura, H; Imai, H; Muramatsu, Y; Niu, K; Nozaki, M | 1 |
| Humes, JL; Kuehl, FA; Sadowski, SJ; Winter, CA | 1 |
| Whittle, BJ | 1 |
| Bailey, RR; Lynn, KL; Munn, E | 1 |
| Juvakoski, T; Lassus, A | 1 |
| Dyczek-Parys, E; Gabryel, A; Gałaszek, Z; Jonderko, G; Nowicki, L; Szczesny-Siwinski, H | 1 |
| Kyuki, K | 1 |
| Köhler, G | 1 |
| Akbaraly, R; Brachet-Liermain, A; Laclau-Lacrouts, B; Leng, JJ; White, P | 1 |
| Chanaud, B; Chancerelle, Y; De Sousa, M; Florentin, I; Giroud, JP; Kergonou, JF; Masson, I; Mathieu, J; Strazlko, S | 1 |
| Carganico, G; Giachetti, A; Giuliani, S; Maggi, CA; Meini, S; Santicioli, P | 1 |
| Dainaka, J; Hashii, H; Inoue, K; Kimura, K; Motonaga, A; Nishimura, T; Ueda, F; Yamate, K | 1 |
| Aguejouf, O; Doutremepuich, C; Doutremepuich, F; Imbault, P; Oualane, FA | 1 |
| Damas, J; Remacle-Volon, G; Sampaio, CA; Souza Pinto, JC | 1 |
| Baeyens, W; Donato, MG; Sandra, P; van den Bossche, W | 1 |
| Leden, I; Rubin, B; Uddenfeldt, P | 1 |
| Aronson, JK; Chappell, MJ; Godfrey, KR; Yew, MK | 1 |
| Itoh, K; Nakao, M; Shichijo, S; Tanaka, H; Tsuboi, I | 1 |
| Higuchi, T; Hirobe, M; Komuro, M | 1 |
| English, N; Hughes, V; Wolf, CR | 1 |
| Iwata, K; Murakami, N; Naruse, T; Takase, H; Tomita, T | 1 |
| Abo, T; Arai, K; Takahashi, HE; Toyabe, S; Yamamura, S | 1 |
| Jamali, F; Lovlin, R; Vakily, M | 1 |
| Fox, SM; Johnston, SA | 1 |
| Bustamante, D; Le Bars, D; Paeile, C; Willer, JC | 1 |
| Baker, P; Bensen, W; Gent, M; Grace, E; Ludwin, D; Roberts, R; Tugwell, P | 1 |
| Agut, J; Conejo, L; Márquez, M; Ortiz, JA; Palop, D; Sacristán, A | 1 |
| Canesi, B; Dal Prà, A; Ferri, S; Lucchini, M; Marcolongo, R; Oriente, P; Perpignano, G; Serni, U; Tirri, G; Trotta, F | 1 |
| Ando, T; Himeno, M; Kataoka, M; Sugimoto, K; Tobetto, K; Yamamoto, Y | 1 |
| Chouini-Lalanne, N; Defais, M; Paillous, N | 1 |
| Doi, T; Ito, A; Kido, H; Kimura, K; Kodera, N; Murakami, N; Naruse, T | 1 |
| Bisso, G; Celle, G; Cimmino, MA; Mela, GS; Mele, MR; Parisi, M; Pivari, M; Savarino, V; Zentilin, P | 1 |
| Abordo, EA; Bowden, K; Huntington, AP; Powell, SL | 1 |
| Bianchi Porro, G; Caruso, I; Lazzaroni, M; Manzionna, G; Montrone, F; Petrillo, M | 1 |
| Sanderson, SD; Shiels, IA; Taylor, SM | 1 |
| Harmon, FA; Rakestraw, PC; Snyder, JR; Van Hoogmoed, L | 1 |
| Deninger, MJ; Schoenwald, RD | 1 |
| Fujii, M; Hori, N; Kawahara, E; Matsumoto, M; Shiozawa, K; Wakabayashi, K | 1 |
| Mardones, C; Ríos, A; Valcárcel, M | 1 |
| Abdel-Hamid, ME; Hamza, H; Novotny, L | 1 |
| Lozano, JJ; Pouplana, R; Ruiz, J | 1 |
| Chua, SH; Tan, E; Tang, MB | 1 |
| Kawasaki, H; Kurosaki, Y; Maeda, H; Ohashi, E; Sano, A | 1 |
| Cowan, A; Raffa, RB; Tallarida, RJ | 1 |
| Drake, CM; Snyder, JR; Van Hoogmoed, LM | 1 |
| Djordjevic, J; Michniak, B; Uhrich, KE | 1 |
| Ng, B; Tajimi, M; Takagi-Matsumoto, H; Tsukimi, Y | 1 |
| Lin, XF; Liu, BK; Wang, JL; Wang, N; Wu, Q | 1 |
| Chattopadhyay, P; Huff, R; Shekunov, BY | 1 |
| Andjelić, S; Bezwada, R; Diluccio, R; Jamiolkowski, DD; Mijović, J; Yuan, J; Zhang, H | 1 |
| Edwards, RM; Evans, C; Hieble, JP; McCafferty, GP; Wibberley, A | 1 |
| Ishihara, K; Kimura, M; Takai, M | 1 |
| Blanzat, M; Bordat, P; Consola, S; Garrigues, JC; Perez, E; Rico-Lattes, I | 1 |
| Cárdenas, S; Simonet, BM; Suárez, B; Valcárcel, M | 1 |
| Boyd, B; Chattopadhyay, P; Cipolla, D; Farr, S; Shekunov, BY; Yim, D | 1 |
| Andoh, T; Kamimura, K; Kawai, S; Kuraishi, Y; Nakano, T; Nojima, H; Ohtsuka, E | 1 |
| Chancellor, MB; de Groat, WC; Kihara, K; Masuda, H; Matsuoka, Y; Saito, K; Yoshida, S; Yoshimura, N | 1 |
| Fang, L; He, Z; Xu, Y; Zhao, L; Zhao, Y | 1 |
| Fang, L; He, Z; Liu, S; Xu, Y; Zhao, L; Zhao, Y | 1 |
| Kikuchi, S; Konno, S; Sekiguchi, M; Shirasaka, M | 1 |
| Cárdenas, S; Cruz-Vera, M; Lucena, R; Valcárcel, M | 1 |
| Asami, M; Fujiwara, J; Kunikane, S; Manabe, S; Matsuda, M; Simazaki, D | 1 |
| Au, AL; Chan, SW; Kwan, YW; Lee, SM; Leung, GP; Li, RW; Seto, SW; Tse, CM | 1 |
| Corrigan, OI; Li, X | 1 |
| Gynther, M; Haapakoski, P; Järvinen, T; Laine, K; Leppänen, J; Peura, L; Rautio, J; Ropponen, J | 1 |
| Jiang, MH; Liu, HL; Wu, GC | 1 |
| Chasovskikh, E; Imran ul-haq, M; Signorell, R | 1 |
| Unlü, B; van Leeuwen, JS; Vermeulen, NP; Vos, JC | 1 |
| Alcudia-León, MC; Cárdenas, S; Lucena, R; Riaño, S; Valcárcel, M | 1 |
| El-Haggar, SM; Elmorsi, YM; Ibrahim, OM; Mabrouk, MM | 1 |
| Boelsterli, UA; Fujimoto, K; Lee, KK; Redinbo, MR; Saitta, KS; Zhang, C | 1 |
| Amidon, GE; Amidon, GL; Krieg, BJ; Taghavi, SM | 1 |
| Duangjit, S; Kumpugdee-Vollrath, M; Mehr, LM; Ngawhirunpat, T | 1 |
| Antunes, E; Hyslop, S; Linardi, A; Rocha-E-Silva, TA | 1 |
| Idaka, S; Ishigami, K; Kondo, R; Satoh, H; Shinoda, T; Shiotani, S | 1 |
| Cheng, YT; Lu, CC; Yen, GC | 1 |
| Kramulová, B; Marsik, P; Rezek, J; Tauchen, J; Vaněk, T; Židková, M | 1 |
| Beaulieu, JF; Thibault, MP; Tremblay, É; Wallace, JL | 1 |
| Elshaer, SL; Shaaban, MI; Shaldam, MA | 1 |
| Du, G; Fang, Z; Gong, N; Lu, Y; Xing, C; Xing, W; Yu, H; Zhang, B | 1 |
13 review(s) available for ketoprofen and indomethacin
| Article | Year |
|---|---|
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic | 2000 |
UDP-glucuronosyltransferases and clinical drug-drug interactions.
Topics: Clinical Trials as Topic; Drug Interactions; Enzyme Activation; Enzyme Induction; Glucuronides; Glucuronosyltransferase; Humans; Pharmaceutical Preparations; Pharmacogenetics; Polymorphism, Genetic | 2005 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Antiinflammatory drugs.
Topics: Adult; Anti-Inflammatory Agents; Apazone; Arthritis, Rheumatoid; Aspirin; Benzylidene Compounds; Child; Drug Evaluation; Female; Humans; Ibuprofen; Indenes; Indomethacin; Ketoprofen; Mefenamic Acid; Naproxen; Phenylacetates; Phenylbutazone; Pregnancy; Pregnancy Complications; Propionates; Tolmetin | 1977 |
[Nonsteroid antirheumatic agents].
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Fenoprofen; Flufenamic Acid; Humans; Indomethacin; Ketoprofen; Mefenamic Acid; Naproxen; Phenylbutazone; Propionates; Salicylates | 1977 |
[Drug therapy of ankylosing spondyloarthritis (Bechterew's disease)].
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Apazone; Butadienes; Cyclophosphamide; Diclofenac; Drug Combinations; Drug Evaluation; Glycolates; Gold; Humans; Ibuprofen; Indomethacin; Ketoprofen; Levamisole; Naproxen; Oxyphenbutazone; Phenylbutazone; Salicylates; Spondylitis, Ankylosing; Sulindac | 1978 |
[The role of non steroidal anti-inflammatory agents in the treatment of renal colic].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Colic; Diclofenac; Humans; Indomethacin; Ketoprofen; Kidney Diseases | 1989 |
Non-steroidal and analgesic therapy in the elderly.
Topics: Acetaminophen; Aged; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents; Apazone; Aspirin; Central Nervous System Diseases; Chemical and Drug Induced Liver Injury; Diclofenac; Drug Hypersensitivity; Gastrointestinal Diseases; Hematologic Diseases; Humans; Ibuprofen; Indomethacin; Ketoprofen; Kidney Diseases; Kinetics; Naproxen; Phenylbutazone; Piroxicam; Salicylates; Thiazines | 1986 |
Granulomatous interstitial nephritis after nonsteroidal anti-inflammatory drugs.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Female; Humans; Indomethacin; Ketoprofen; Nephritis, Interstitial | 1988 |
Non-steroidal anti-inflammatory drugs (NSAID'S) as analgesics in dentistry - a review.
Topics: Analgesics; Anti-Inflammatory Agents; Aspirin; Dental Care; Diflunisal; Humans; Ibuprofen; Indomethacin; Ketoprofen; Oxyphenbutazone; Pain, Postoperative; Phenylbutazone | 1983 |
Update on ibuprofen for rheumatoid arthritis.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Drug Tolerance; Fenoprofen; Humans; Ibuprofen; Indomethacin; Ketoprofen; Naproxen; Piroxicam; Sulindac; Thiazines; Tolmetin | 1984 |
Use of carprofen for the treatment of pain and inflammation in dogs.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carbazoles; Clonixin; Cyclooxygenase Inhibitors; Dog Diseases; Dogs; Ibuprofen; Indomethacin; Ketoprofen; Meclofenamic Acid; Meloxicam; Naproxen; Osteoarthritis; Pain; Phenylbutazone; Piroxicam; Thiazines; Thiazoles | 1997 |
Phytochemicals enhance antioxidant enzyme expression to protect against NSAID-induced oxidative damage of the gastrointestinal mucosa.
Topics: Angiogenesis Inducing Agents; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Apoptosis; Aspirin; Diclofenac; Flavonoids; Gastric Mucosa; Gastrointestinal Tract; Humans; Indomethacin; Inflammation; Ketoprofen; Oxidative Stress; Phytochemicals; Protective Agents | 2017 |
36 trial(s) available for ketoprofen and indomethacin
| Article | Year |
|---|---|
Evaluation of analgesic action and efficacy of antirheumatic drugs. Study of 10 drugs in 684 patients with rheumatoid arthritis.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Flurbiprofen; Humans; Ibuprofen; Indomethacin; Ketoprofen; Mefenamic Acid; Pain; Phenylacetates; Placebos; Prednisone; Salicylates | 1976 |
Single nightly administration of ketoprofen (Orudis) and indomethacin suppositories in the management of osteoarthritis: a double-blind trial.
Topics: Clinical Trials as Topic; Double-Blind Method; Humans; Indomethacin; Ketoprofen; Middle Aged; Osteoarthritis; Phenylpropionates; Suppositories | 1977 |
Double-blind study of ketoprofen and indomethacin in juvenile chronic arthritis.
Topics: Adolescent; Arthritis, Juvenile; Child; Child, Preschool; Chronic Disease; Clinical Trials as Topic; Double-Blind Method; Humans; Indomethacin; Ketoprofen; Phenylpropionates | 1978 |
Panel discussion on clinical trials: comparison of different trials.
Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Evaluation; Humans; Indomethacin; Ketoprofen; Research Design | 1978 |
Ketoprofen: double-blind cross-over study with indomethacin administered as a combined suppository/capsule regime in patients with rheumatoid arthritis. A preliminary report.
Topics: Administration, Oral; Adult; Aged; Arthritis, Rheumatoid; Capsules; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Indomethacin; Ketoprofen; Male; Middle Aged; Phenylpropionates; Rectum; Suppositories | 1978 |
Parenteral administration of ketoprofen in osteoarthritis: a double-blind trial versus the N-methyl-d-glucamine salt of indomethacin.
Topics: Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Female; Gait; Humans; Indomethacin; Injections, Intramuscular; Ketoprofen; Male; Middle Aged; Movement; Osteoarthritis; Pain; Phenylpropionates | 1979 |
[Clinical efficacy of ketoprofen in rheumatology].
Topics: Adult; Aged; Clinical Trials as Topic; Drug Evaluation; Female; Humans; Indomethacin; Ketoprofen; Male; Middle Aged; Phenylpropionates; Rheumatic Diseases | 1978 |
The refief of primary dysmenorrhea by ketoprofen and indomethacin.
Topics: Adolescent; Adult; Double-Blind Method; Dysmenorrhea; Female; Humans; Indomethacin; Ketoprofen; Menstruation; Phenylpropionates; Prostaglandin Antagonists; Random Allocation; Work Capacity Evaluation | 1979 |
A new (?) Clinical headache entity "chronic paroxysmal hemicrania" 2.
Topics: Affective Symptoms; Aspirin; Cerebrovascular Circulation; Chronic Disease; Clinical Trials as Topic; Cornea; Diagnosis, Differential; Female; Headache; Histamine; Humans; Indomethacin; Ketoprofen; Kininogens; Kinins; Middle Aged; Migraine Disorders; Prednisone; Prostaglandins E | 1976 |
Ketoprofen and indomethacin in the treatment of rheumatoid arthritis: a double-blind cross-over trial.
Topics: Adult; Aged; Arthritis, Rheumatoid; Benzophenones; Clinical Trials as Topic; Drug Administration Schedule; Female; Humans; Indomethacin; Ketoprofen; Male; Middle Aged | 1975 |
A double-blind cross-over study of ketoprofen and phenylbutazone in rheumatoid arthritis.
Topics: Analgesics; Arthritis, Rheumatoid; Benzophenones; Clinical Trials as Topic; Drug Evaluation; Gastrointestinal Diseases; Humans; Indomethacin; Ketoprofen; Phenylbutazone | 1976 |
Ketoprofen -- a new anti-rheumatic agent.
Topics: Analgesics; Arthritis, Rheumatoid; Benzophenones; Clinical Trials as Topic; Drug Evaluation; Gastrointestinal Diseases; Hip Joint; Humans; Indomethacin; Ketoprofen; Osteoarthritis; Phenylbutazone | 1976 |
Ketoprofen in rheumatoid arthritis: its tolerance and therapeutic effect.
Topics: Adult; Aged; Analgesics; Arthritis, Rheumatoid; Benzophenones; Clinical Trials as Topic; Drug Evaluation; Eye; Female; Gastrointestinal Diseases; Headache; Humans; Indomethacin; Ketoprofen; Male; Middle Aged; Placebos; Time Factors | 1976 |
Clinical evaluation of ketoprofen (19.583 R.P.) in rheumatoid arthritis. Double-blind cross-over comparison with indomethacin.
Topics: Adult; Aged; Analgesics; Arthritis, Rheumatoid; Benzophenones; Clinical Trials as Topic; Drug Evaluation; Female; Gastrointestinal Diseases; Headache; Humans; Indomethacin; Ketoprofen; Male; Middle Aged; Time Factors | 1976 |
A comparative trial of large doses of ketoprofen and indomethacin in the treatment of rheumatoid arthritis.
Topics: Adolescent; Adult; Arthritis, Rheumatoid; Benzophenones; Clinical Trials as Topic; Female; Humans; Indomethacin; Ketoprofen; Male; Middle Aged | 1976 |
Ketoprofen - clinical efficacy.
Topics: Acetaminophen; Anti-Inflammatory Agents; Arthritis; Arthritis, Rheumatoid; Aspirin; Benzophenones; Clinical Trials as Topic; Gout; Humans; Ibuprofen; Indomethacin; Ketoprofen; Phenylbutazone; Placebos; Sciatica; Spondylitis, Ankylosing | 1976 |
Clinical evaluation of ketoprofen (Orudis) in rheumatoid arthritis: a double-blind cross-over comparison with indomethacin.
Topics: Adult; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Benzophenones; Clinical Trials as Topic; Humans; Indomethacin; Ketoprofen; Middle Aged | 1976 |
A double-blind crossover comparison of Orudis (ketoprofen) and indomethacin in the treatment of rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Benzophenones; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Indomethacin; Ketoprofen; Male; Middle Aged | 1976 |
Ketoprofen versus indomethacin in patients with acute gouty arthritis: a multicenter, double blind comparative study.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Arthritis, Gouty; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Indomethacin; Ketoprofen; Male; Middle Aged; Multicenter Studies as Topic; Pain; Phenylpropionates; Random Allocation | 1988 |
Ketoprofen versus indomethacin in patients with rheumatoid arthritis: a multicenter double blind comparative study.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Double-Blind Method; Female; Humans; Indomethacin; Ketoprofen; Male; Middle Aged; Multicenter Studies as Topic; Pain Measurement; Phenylpropionates; Random Allocation | 1988 |
A prospective endoscopic study of the effect of Orudis and Oruvail on the upper gastrointestinal tract, in patients with osteoarthritis.
Topics: Administration, Oral; Delayed-Action Preparations; Double-Blind Method; Duodenitis; Endoscopy; Esophagitis; Female; Gastritis; Humans; Indomethacin; Ketoprofen; Male; Middle Aged; Osteoarthritis; Phenylpropionates; Prospective Studies; Random Allocation | 1988 |
Effects of acute and chronic dosing of NSAIDs in patients with renal insufficiency.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Female; Glomerular Filtration Rate; Hemodynamics; Humans; Indomethacin; Ketoprofen; Kidney; Kidney Failure, Chronic; Male; Middle Aged; Renal Circulation | 1986 |
Double-blind preference and compliance multicentre study in osteoarthritis: once-a-day treatment.
Topics: Adult; Aged; Aspirin; Clinical Trials as Topic; Diclofenac; Double-Blind Method; Drug Administration Schedule; Humans; Indomethacin; Indoprofen; Ketoprofen; Middle Aged; Naproxen; Osteoarthritis; Pain; Patient Compliance; Piroxicam; Thiazines | 1985 |
The prostaglandin inhibitor effect of antiinflammatory drugs in the therapy of male infertility.
Topics: Adult; Anti-Inflammatory Agents; Cyclic AMP; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Follicle Stimulating Hormone; Humans; Indomethacin; Ketoprofen; Luteinizing Hormone; Male; Oligospermia; Prostaglandin Antagonists; Prostaglandins E; Prostaglandins F; Semen; Sperm Count; Sperm Motility; Testosterone | 1984 |
[Double-blind comparative study of slow-release ketoprofen tablets and indomethacin in coxarthrosis and gonarthrosis].
Topics: Aged; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind Method; Female; Hip Joint; Humans; Indomethacin; Ketoprofen; Knee Joint; Male; Middle Aged; Osteoarthritis; Phenylpropionates; Random Allocation; Tablets | 1983 |
[Comparative double-blind study of ketoprofen slow-release tablets and indomethacin in coxarthrosis and gonarthrosis].
Topics: Aged; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind Method; Female; Hip Joint; Humans; Indomethacin; Ketoprofen; Knee Joint; Male; Middle Aged; Osteoarthritis; Pain; Phenylpropionates; Tablets | 1983 |
Double-blind comparison of glucametacin and ketoprofen in chronic arthropathies.
Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Indomethacin; Ketoprofen; Male; Middle Aged; Osteoarthritis; Phenylpropionates | 1983 |
Update on ibuprofen for rheumatoid arthritis.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Drug Tolerance; Fenoprofen; Humans; Ibuprofen; Indomethacin; Ketoprofen; Naproxen; Piroxicam; Sulindac; Thiazines; Tolmetin | 1984 |
Comparison of the analgesic effect of ten nonsteroidal anti-inflammatory drugs.
Topics: Adult; Aged; Analgesics; Anti-Inflammatory Agents; Apazone; Arthritis, Rheumatoid; Aspirin; Carbazoles; Diclofenac; Female; Humans; Ibuprofen; Indomethacin; Ketoprofen; Male; Middle Aged; Naproxen; ortho-Aminobenzoates; Quinazolines | 1984 |
A double-blind cross-over evaluation of ketoprofen and indomethacin in Reiter's disease.
Topics: Adult; Aged; Arthritis; Arthritis, Reactive; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Indomethacin; Ketoprofen; Male; Middle Aged; Phenylpropionates | 1982 |
[Comparative crossover double-blind study of profenid and indomethacin patients with rheumatoid arthritis].
Topics: Adult; Aged; Arthritis, Rheumatoid; Double-Blind Method; Female; Humans; Indomethacin; Ketoprofen; Male; Middle Aged; Phenylpropionates; Random Allocation | 1982 |
A double-blind comparison of oral ketoprofen 'controlled release' and indomethacin suppository in the treatment of rheumatoid arthritis with special regard to morning stiffness and pain on awakening.
Topics: Administration, Rectal; Adult; Aged; Ambulatory Care; Arthritis, Rheumatoid; Central Nervous System Diseases; Delayed-Action Preparations; Double-Blind Method; Female; Gastrointestinal Diseases; Humans; Indomethacin; Ketoprofen; Male; Medical Records; Middle Aged; Pain; Pain Measurement; Severity of Illness Index; Suppositories; Time Factors | 1993 |
Interaction between cyclosporin A and nonsteroidal antiinflammatory drugs.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Combined Modality Therapy; Creatinine; Cross-Over Studies; Cyclosporine; Drug Interactions; Female; Glomerular Filtration Rate; Humans; Indomethacin; Ketoprofen; Male; Middle Aged; Treatment Outcome | 1997 |
Efficacy and tolerability of ketoprofen 200 mg controlled-release cps vs indomethacin 50 mg cps in patients with symptomatic hip osteoarthritis. A multicentre study.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Capsules; Drug Administration Schedule; Female; Humans; Indomethacin; Ketoprofen; Male; Middle Aged; Osteoarthritis, Hip; Patient Satisfaction | 1997 |
Prevention of gastroduodenal damage with omeprazole in patients receiving continuous NSAIDs treatment. A double blind placebo controlled study.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Diclofenac; Double-Blind Method; Endoscopy, Digestive System; Female; Follow-Up Studies; Gastric Mucosa; Humans; Indomethacin; Intestinal Mucosa; Ketoprofen; Male; Middle Aged; Omeprazole; Peptic Ulcer; Rheumatic Diseases; Safety; Treatment Outcome | 1998 |
[Dexketoprofen trometamol in the treatment of chronic prostatitis/chronic pelvic pain syndrome].
Topics: Adult; Chronic Disease; Humans; Indomethacin; Ketoprofen; Male; Pelvic Pain; Prazosin; Prostatitis; Tromethamine | 2009 |
186 other study(ies) available for ketoprofen and indomethacin
| Article | Year |
|---|---|
Structure-Activity Relationship of novel phenylacetic CXCR1 inhibitors.
Topics: Allosteric Regulation; Allosteric Site; Chemistry, Organic; Chemistry, Pharmaceutical; Chemotaxis; Humans; Inhibitory Concentration 50; Models, Chemical; Models, Molecular; Molecular Conformation; Mutagenesis; Mutation; Receptors, Interleukin-8A; Structure-Activity Relationship | 2009 |
6,11-Dihydro-11-oxodibenz [b,e] oxepinacetic acids with potent antiinflammatory activity.
Topics: Acetates; Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Dibenzoxepins; Edema; Female; Lethal Dose 50; Male; Mice; Rats; Spasm; Stomach Ulcer; Structure-Activity Relationship | 1976 |
Antiinflammatory and aldose reductase inhibitory activity of some tricyclic arylacetic acids.
Topics: Acetates; Aldehyde Reductase; Animals; Anti-Inflammatory Agents; Cyclooxygenase Inhibitors; Heterocyclic Compounds; Male; Mice; Rabbits; Rats; Structure-Activity Relationship; Sugar Alcohol Dehydrogenases | 1986 |
Esters of N,N-disubstituted 2-hydroxyacetamides as a novel highly biolabile prodrug type for carboxylic acid agents.
Topics: Acetamides; Biotransformation; Carboxylic Acids; Half-Life; Humans; Indicators and Reagents; Kinetics; Structure-Activity Relationship | 1987 |
Bulky amine analogues of ketoprofen: potent antiinflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Chemical Phenomena; Chemistry; Drug Evaluation, Preclinical; Edema; Indicators and Reagents; Ketoprofen; Magnetic Resonance Spectroscopy; Male; Phenylpropionates; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1984 |
Interactions of nonsteroidal anti-inflammatory drugs with rat renal organic anion transporter, OAT-K1.
Topics: Animals; Anion Transport Proteins; Anti-Inflammatory Agents, Non-Steroidal; Carrier Proteins; Drug Interactions; Indomethacin; Ketoprofen; Kidney; Male; Methotrexate; Rats; Rats, Wistar; Tetraethylammonium Compounds | 1997 |
Transport properties of nonsteroidal anti-inflammatory drugs by organic anion transporter 1 expressed in Xenopus laevis oocytes.
Topics: Animals; Anion Transport Proteins; Anti-Inflammatory Agents, Non-Steroidal; Biological Transport; Carrier Proteins; Oocytes; Xenopus laevis | 1999 |
Prediction of drug solubility from Monte Carlo simulations.
Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility | 2000 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Nonsteroidal anti-inflammatory drugs efficiently reduce the transport and cytotoxicity of adefovir mediated by the human renal organic anion transporter 1.
Topics: Adenine; Anion Transport Proteins; Anti-Inflammatory Agents, Non-Steroidal; Antiviral Agents; Biological Transport; Carrier Proteins; Humans; Kidney; Organophosphonates; Structure-Activity Relationship | 2000 |
Interaction between methotrexate and nonsteroidal anti-inflammatory drugs in organic anion transporter.
Topics: Animals; Anion Transport Proteins; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites, Antineoplastic; Carrier Proteins; Kinetics; Methotrexate; Oocytes; Probenecid; Uricosuric Agents; Xenopus laevis | 2000 |
Cheminformatic models to predict binding affinities to human serum albumin.
Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids | 2001 |
Comparative inhibitory effects of different compounds on rat oatpl (slc21a1)- and Oatp2 (Slc21a5)-mediated transport.
Topics: Algorithms; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibiotics, Antitubercular; Antimalarials; Biological Transport, Active; Digoxin; Enzyme Inhibitors; Estradiol; Ibuprofen; LLC-PK1 Cells; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Organic Cation Transport Proteins; Quinidine; Quinine; Rats; Rifampin; Swine | 2002 |
Characterization of methotrexate transport and its drug interactions with human organic anion transporters.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Transport; Cells, Cultured; Humans; Indomethacin; Kinetics; Liver-Specific Organic Anion Transporter 1; Methotrexate; Mice; Mice, Transgenic; Nerve Tissue Proteins; Organic Anion Transporters, Sodium-Independent; Phenylbutazone; Potassium Channels; Potassium Channels, Tandem Pore Domain; Probenecid | 2002 |
The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs.
Topics: Adenosine Triphosphate; Alprostadil; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Transport; Cell Line; Cell Membrane; Diffusion; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Humans; Insecta; Multidrug Resistance-Associated Proteins; Prostaglandins; Prostaglandins A; Prostaglandins F; Ribosomal Proteins; RNA Interference; RNA, Small Interfering; Thromboxane B2; Time Factors | 2003 |
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability.
Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties | 2004 |
Synthesis and pharmacological evaluation of amide conjugates of NSAIDs with L-cysteine ethyl ester, combining potent antiinflammatory and antioxidant properties with significantly reduced gastrointestinal toxicity.
Topics: Amides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Cholesterol; Cysteine; Drug Evaluation; Gastrointestinal Diseases; Lipoproteins, LDL; Mice; Rats; Triglycerides | 2004 |
Novel cyclooxygenase-1 inhibitors discovered using affinity fingerprints.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Combinatorial Chemistry Techniques; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Drug Design; Drug Evaluation, Preclinical; Ibuprofen; Inhibitory Concentration 50; Isoenzymes; Models, Molecular; Models, Theoretical; Molecular Structure; Prospective Studies; Prostaglandin-Endoperoxide Synthases; Quantitative Structure-Activity Relationship | 2004 |
Predicting human serum albumin affinity of interleukin-8 (CXCL8) inhibitors by 3D-QSPR approach.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Chemical Phenomena; Chemistry, Physical; Humans; In Vitro Techniques; Interleukin-8; Models, Molecular; Phenylpropionates; Protein Binding; Quantitative Structure-Activity Relationship; Serum Albumin; Stereoisomerism | 2005 |
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water | 2005 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Parallel artificial membrane permeability assay: a new membrane for the fast prediction of passive human skin permeability.
Topics: 1-Octanol; Diffusion; Dimethylpolysiloxanes; Humans; In Vitro Techniques; Membranes, Artificial; Myristates; Permeability; Skin; Skin Absorption; Water | 2006 |
In silico and in vitro filters for the fast estimation of skin permeation and distribution of new chemical entities.
Topics: Humans; Membranes, Artificial; Models, Biological; Models, Molecular; Octanols; Permeability; Pharmaceutical Preparations; Skin Absorption; Water | 2007 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds.
Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Effect of some analgesics on paraoxonase-1 purified from human serum.
Topics: Analgesics; Aryldialkylphosphatase; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzyme Inhibitors; Humans; Ketoprofen; Molecular Structure; Piroxicam; Serum | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Development of an in silico model for human skin permeation based on a Franz cell skin permeability assay.
Topics: 1-Methyl-3-isobutylxanthine; Cell Line; Cell Membrane Permeability; Humans; Models, Biological; Quantitative Structure-Activity Relationship; Skin Absorption | 2010 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
A combined spectroscopic and crystallographic approach to probing drug-human serum albumin interactions.
Topics: Binding Sites; Crystallography, X-Ray; Drug Interactions; Humans; Pharmaceutical Preparations; Protein Binding; Protein Structure, Tertiary; Serum Albumin; Spectrometry, Fluorescence | 2010 |
Toxicological evaluation of acyl glucuronides of nonsteroidal anti-inflammatory drugs using human embryonic kidney 293 cells stably expressing human UDP-glucuronosyltransferase and human hepatocytes.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Camphanes; Comet Assay; DNA Damage; Glucuronides; Glucuronosyltransferase; HEK293 Cells; Hepatocytes; Humans; Kidney | 2011 |
Prediction of drug intestinal absorption by new linear and non-linear QSPR.
Topics: Humans; Intestinal Absorption; Linear Models; Molecular Conformation; Nonlinear Dynamics; Permeability; Pharmaceutical Preparations; Probability; Quantitative Structure-Activity Relationship; Thermodynamics | 2011 |
Identification of curcumin derivatives as human glyoxalase I inhibitors: A combination of biological evaluation, molecular docking, 3D-QSAR and molecular dynamics simulation studies.
Topics: Curcumin; Drug Design; Enzyme Inhibitors; Genetic Vectors; Humans; Inhibitory Concentration 50; Lactoylglutathione Lyase; Models, Molecular; Molecular Dynamics Simulation; Molecular Structure; Molecular Targeted Therapy; Plasmids; Protein Binding; Protein Conformation; Quantitative Structure-Activity Relationship | 2011 |
Human pharmacokinetic prediction of UDP-glucuronosyltransferase substrates with an animal scale-up approach.
Topics: Administration, Oral; Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Area Under Curve; Cytochrome P-450 Enzyme System; Dogs; Drug Evaluation, Preclinical; Glucuronides; Glucuronosyltransferase; Half-Life; Humans; Macaca fascicularis; Male; Mice; Pharmaceutical Preparations; Predictive Value of Tests; Rats; Rats, Sprague-Dawley; Species Specificity | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Structural investigation into the inhibitory mechanisms of indomethacin and its analogues towards human glyoxalase I.
Topics: Binding Sites; Catalytic Domain; Humans; Indomethacin; Kinetics; Lactoylglutathione Lyase; Molecular Dynamics Simulation; Thermodynamics | 2011 |
Self-organizing molecular field analysis of NSAIDs: assessment of pharmacokinetic and physicochemical properties using 3D-QSPkR approach.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemical Phenomena; Computational Biology; Least-Squares Analysis; Models, Molecular; Molecular Conformation; Quantitative Structure-Activity Relationship | 2012 |
Modified acidic nonsteroidal anti-inflammatory drugs as dual inhibitors of mPGES-1 and 5-LOX.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Cell Line; Humans; Indomethacin; Intramolecular Oxidoreductases; Lipoxygenase Inhibitors; Microsomes; Prostaglandin-E Synthases; Pyrazoles; Structure-Activity Relationship; Sulfonamides | 2012 |
High analgesic and anti-inflammatory in vivo activities of six new hybrids NSAIAs tetrahydropyran derivatives.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Mice; Molecular Structure; Motor Activity; Pyrans | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Inhibition of FAAH, TRPV1, and COX2 by NSAID-serotonin conjugates.
Topics: Amidohydrolases; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Flurbiprofen; Humans; Serotonin; TRPV Cation Channels | 2014 |
Effect of new hybrids based on 5,16-pregnadiene scaffold linked to an anti-inflammatory drug on the growth of a human astrocytoma cell line (U373).
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Cell Culture Techniques; Cell Line, Tumor; Cell Proliferation; Humans; Molecular Structure; Pregnadienes; Sulindac; Time Factors | 2015 |
Volume of Distribution in Drug Design.
Topics: Drug Design; Half-Life; Pharmacokinetics | 2015 |
Synthesis and Evaluation of a Radioiodinated Tracer with Specificity for Poly(ADP-ribose) Polymerase-1 (PARP-1) in Vivo.
Topics: Animals; Cell Line, Tumor; Enzyme Inhibitors; Glioblastoma; Humans; Iodine Radioisotopes; Mice; Mice, Nude; Phthalazines; Piperazines; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Tissue Distribution; Tomography, Emission-Computed, Single-Photon | 2015 |
Synthesis and Evaluation of Novel Erlotinib-NSAID Conjugates as More Comprehensive Anticancer Agents.
Topics: | 2015 |
Esters of some non-steroidal anti-inflammatory drugs with cinnamyl alcohol are potent lipoxygenase inhibitors with enhanced anti-inflammatory activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cinnamates; Edema; Esters; Glycine max; Hyperlipidemias; Indoleacetic Acids; Lipoxygenase Inhibitors; Polyethylene Glycols; Propanols; Propionates; Rats; Thioctic Acid | 2015 |
Amides of non-steroidal anti-inflammatory drugs with thiomorpholine can yield hypolipidemic agents with improved anti-inflammatory activity.
Topics: Amides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cholesterol; Cholesterol, LDL; Edema; Hyperlipidemias; Hypolipidemic Agents; Morpholines; Rats; Triglycerides | 2016 |
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat | 2016 |
Synthesis and biological properties of aryl methyl sulfones.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Carrageenan; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Edema; Humans; Male; Mice; Models, Molecular; Molecular Structure; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Structure-Activity Relationship; Sulfones; Thermodynamics | 2018 |
Synthesis and biological evaluation of organoselenium (NSAIDs-SeCN and SeCF
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; Caspase 3; Cell Line, Tumor; DNA; DNA Damage; Drug Screening Assays, Antitumor; Free Radical Scavengers; Humans; Interleukin-2; Molecular Docking Simulation; Organoselenium Compounds; Protein Binding; Proto-Oncogene Proteins c-bcl-2; Thioredoxin Reductase 1 | 2020 |
Identification of Organic Anion Transporter 2 Inhibitors: Screening, Structure-Based Analysis, and Clinical Drug Interaction Risk Assessment.
Topics: Drug Interactions; HEK293 Cells; Humans; Liver; Organic Anion Transporters, Sodium-Independent; Risk Assessment | 2022 |
The role of copper in preventing gastrointestinal damage by acidic anti-inflammatory drugs.
Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chelating Agents; Copper; Edema; Female; In Vitro Techniques; Indomethacin; Ketoprofen; Male; Naproxen; Niflumic Acid; Peptic Ulcer; Prostaglandins E; Pyrroles; Rats | 1976 |
Prostaglandin synthetase systems in rat and rabbit renal medulla and inhibition by non-steroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Hydrogen-Ion Concentration; Ibuprofen; Indomethacin; Ketoprofen; Kidney; Kidney Medulla; Male; Microsomes; Phenylbutazone; Prostaglandins E; Prostaglandins F; Rabbits; Rats | 1977 |
Treatment of Bartter's syndrome in early childhood with prostaglandin synthetase inhibitors.
Topics: Bartter Syndrome; Body Height; Body Weight; Child, Preschool; Cyclooxygenase Inhibitors; Humans; Hyperaldosteronism; Indomethacin; Infant; Ketoprofen; Male; Phenylpropionates; Potassium; Prostaglandins; Renin; Spironolactone | 1978 |
Long-term studies on therapy and tolerance of ketoprofen.
Topics: Arthritis; Arthritis, Rheumatoid; Humans; Indomethacin; Ketoprofen; Kidney; Liver; Phenylpropionates | 1979 |
Inhibition of human leucocytes locomotion by anti-inflammatory drugs.
Topics: Anti-Inflammatory Agents; Aspirin; Cell Movement; Chemotaxis, Leukocyte; Depression, Chemical; Humans; Ibuprofen; Indomethacin; Ketoprofen; Naproxen; Neutrophils; Salicylates | 1979 |
Studies on the effects of anti-inflammatory action of benzoyl-hydrotropic acid (ketoprofen) and other drugs, with special reference to prostaglandin synthesis.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Edema; Foot; Indomethacin; Ketoprofen; Male; Phenylpropionates; Prostaglandins; Prostaglandins E; Prostaglandins F; Rats | 1979 |
Cellular uptake and subcellular distribution of two non-steroidal anti-inflammatory drugs: indomethacin and ketoprofen.
Topics: Animals; Cells, Cultured; Fibroblasts; Indomethacin; Ketoprofen; Phenylpropionates; Rats; Subcellular Fractions; Time Factors | 1979 |
[On the efficiency of new antiinflammatory agents. A comparative study (author's transl)].
Topics: Animals; Anti-Inflammatory Agents; Benzylidene Compounds; Carrageenan; Diclofenac; Edema; Fenoprofen; In Vitro Techniques; Indenes; Indomethacin; Ketoprofen; Naproxen; Phenylbutazone; Protease Inhibitors; Rats | 1977 |
Ketoprofen experiences.
Topics: Aspirin; Humans; Indomethacin; Ketoprofen; Phenylbutazone; Phenylpropionates | 1978 |
Bioavailability of powdered inclusion compounds of nonsteroidal antiinflammatory drugs with beta-cyclodextrin in rabbits and dogs.
Topics: Animals; Anti-Inflammatory Agents; Biological Availability; Dextrins; Dogs; Flufenamic Acid; Ibuprofen; Indomethacin; Ketoprofen; Powders; Rabbits; Starch | 1978 |
Some effects of non-steroidal anti-inflammatory drugs on leucocyte migration.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Cell Movement; Edema; Fenoprofen; Ibuprofen; Indomethacin; Ketoprofen; Leukocytes; Male; Methotrexate; Naproxen; Phenylbutazone; Pleurisy; Rats | 1976 |
Relationship between the inhibitory activity on 'RCS' and prostaglandins synthesis and the anti-inflammatory activity of ketoprofen and several other non-steroidal anti-inflammatory agents.
Topics: Abscess; Animals; Anti-Inflammatory Agents; Aorta; Arachidonic Acids; Aspirin; Benzophenones; Colon; Guinea Pigs; Hydroxy Acids; Ibuprofen; In Vitro Techniques; Indomethacin; Ketoprofen; Lung; Muscle Contraction; Naproxen; Phenylbutazone; Prostaglandin Antagonists; Prostaglandins; Pyrans | 1976 |
Some pharmacological and toxicological studies on ketoprofen.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Benzophenones; Fever; Guinea Pigs; Indomethacin; Inflammation; Ketoprofen; Mice; Pain; Rabbits; Rats | 1976 |
Sensible prescribing. The treatment of rheumatoid arthritis.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Arthroplasty; Aspirin; Cryotherapy; Exercise Therapy; Humans; Hydrostatic Pressure; Immunosuppressive Agents; Indomethacin; Injections, Intra-Articular; Ketoprofen; Methylprednisolone; Oxyphenbutazone; Penicillamine; Phenylbutazone; Pressure | 1975 |
Indomethacin, ketoprofen and corpus luteum regression in the guinea-pig.
Topics: Animals; Anti-Inflammatory Agents; Benzophenones; Corpus Luteum; Estrus; Female; Glass; In Vitro Techniques; Indomethacin; Ketoprofen; Pregnancy; Uterus | 1975 |
[Review of the clinical studies in rheumatoid arthritis with several non steroid anti-inflammatory agents (author's transl)].
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Drug Evaluation; Humans; Indomethacin; Ketoprofen; Phenylbutazone; Pyrroles | 1975 |
Suprofen, a potent antagonist of acetic acid-induced writhing in rats.
Topics: Acetates; Analgesics; Animals; Arachidonic Acids; Aspirin; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Indomethacin; Ketoprofen; Male; Muscle Contraction; Phenylacetates; Phenylbutazone; Phenylpropionates; Prostaglandin Antagonists; Prostaglandins; Rats; Spasm; Thiophenes; Tolmetin | 1975 |
Suprofen, a potent antagonist of ultraviolet-erythema in guinea-pigs.
Topics: Animals; Anti-Inflammatory Agents; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Erythema; Guinea Pigs; Indomethacin; Ketoprofen; Male; Phenylbutazone; Phenylpropionates; Thiophenes; Time Factors; Tolmetin; Ultraviolet Rays | 1975 |
Gastrointestinal effects and acute toxicity of suprofen.
Topics: Animals; Antidiarrheals; Aspirin; Digestive System; Dogs; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Eating; Female; Guinea Pigs; Indomethacin; Ketoprofen; Lethal Dose 50; Male; Mice; Phenylacetates; Phenylpropionates; Rats; Rats, Inbred Strains; Thiophenes; Time Factors; Ulcer | 1975 |
[Comparative study on the activity of various anti-inflammatory agents in chronically developing glomerulonephritis].
Topics: Adolescent; Adult; Anti-Inflammatory Agents; Child; Child, Preschool; Chronic Disease; Dose-Response Relationship, Drug; Glomerulonephritis; Humans; Indomethacin; Ketoprofen; Middle Aged; Phenothiazines; Phenylbutyrates; Proteinuria; Remission, Spontaneous | 1975 |
Longterm drug therapy for rheumatoid arthritis in seven rheumatology private practices: I. Nonsteroidal antiinflammatory drugs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Female; Humans; Indomethacin; Ketoprofen; Long-Term Care; Male; Meclofenamic Acid; Middle Aged; Private Practice; Surveys and Questionnaires | 1992 |
Rapid and sensitive liquid chromatographic assay of mefenamic acid in plasma.
Topics: Carbamazepine; Chromatography, Liquid; Clonazepam; Humans; Hydrogen-Ion Concentration; Indomethacin; Ketoprofen; Least-Squares Analysis; Mefenamic Acid; Phenobarbital; Phenytoin; Salicylates; Salicylic Acid; Sensitivity and Specificity; Valproic Acid | 1992 |
In vitro effect of nonsteroidal antiinflammatory drugs on proteoglycanase and collagenase activity in human osteoarthritic cartilage.
Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Diclofenac; Endopeptidases; Female; Humans; Indomethacin; Ketoprofen; Male; Metalloendopeptidases; Microbial Collagenase; Middle Aged; Osteoarthritis, Hip; Piroxicam; Salicylates; Salicylic Acid | 1991 |
In vivo effects of nonsteroidal antiinflammatory drugs on rat skin and synovial mast cell-induced vasopermeability.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Capillary Permeability; Cimetidine; Diphenhydramine; Indomethacin; Ketoprofen; Male; Mast Cells; Rats; Rats, Inbred Strains; Skin; Synovial Membrane | 1991 |
Comparison of the effects of non-steroidal anti-inflammatory drugs (NSAIDs) on proteoglycan synthesis by articular cartilage explant and chondrocyte monolayer cultures.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Cells, Cultured; Culture Techniques; Diclofenac; Indomethacin; Ketoprofen; Piroxicam; Propionates; Proteoglycans; Rabbits; Time Factors | 1991 |
A method to predict the percutaneous permeability of various compounds: shed snake skin as a model membrane.
Topics: Animals; Cell Membrane Permeability; Hydrocortisone; Ibuprofen; Indomethacin; Ketoprofen; Models, Biological; Molecular Weight; Naproxen; Particle Size; Progesterone; Skin; Snakes | 1990 |
In vitro capacity of various cyclooxygenase inhibitors to revert immune suppression caused by radiation therapy for breast cancer.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Breast Neoplasms; Cyclooxygenase Inhibitors; Diclofenac; Female; Humans; Immune Tolerance; In Vitro Techniques; Indomethacin; Ketoprofen; Lymphocyte Activation; Lysine; Meclofenamic Acid; Middle Aged; Phytohemagglutinins | 1990 |
Effects of prostaglandin and leukotriene inhibitors on the growth of human glioma spheroids.
Topics: Arachidonic Acids; Dexamethasone; Glioma; Humans; Indomethacin; Ketoprofen; Leukotriene Antagonists; Lipoxygenase Inhibitors; Masoprocol; Mitosis; Prostaglandin Antagonists; Quinacrine; Tumor Cells, Cultured | 1990 |
Etodolac preserves cartilage-specific phenotype in human chondrocytes: effects on type II collagen synthesis and associated mRNA levels.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cartilage; Cells, Cultured; Collagen; Dinoprostone; Etodolac; Fibronectins; Humans; Indoleacetic Acids; Indomethacin; Ketoprofen; Phenotype; Procollagen; RNA, Messenger; Time Factors | 1990 |
Evaluation of the effect of antiarthritic drugs on the secretion of proteoglycans by lapine chondrocytes using a novel assay procedure.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Cells, Cultured; Diclofenac; Glycosaminoglycans; Indomethacin; Ketoprofen; Methods; Pentosan Sulfuric Polyester; Propionates; Proteoglycans; Rabbits | 1989 |
Neonatal renal dysfunction and intrauterine exposure to prostaglandin synthesis inhibitors.
Topics: Acute Kidney Injury; Anti-Inflammatory Agents, Non-Steroidal; Betamethasone; Cesarean Section; Cyclooxygenase Inhibitors; Diseases in Twins; Drug Therapy, Combination; Female; Humans; Indomethacin; Infant, Newborn; Infant, Premature, Diseases; Ketoprofen; Kidney Function Tests; Male; Obstetric Labor, Premature; Pregnancy | 1989 |
Study on the in vitro assay method for evaluating the inhibitory effect of various substances on the production of plasma kallikrein.
Topics: Aminopyrine; Aspirin; Humans; Ibuprofen; Indomethacin; Kallikreins; Ketoprofen; Kinetics; Kinins; Morphine; Pentazocine; Prekallikrein | 1989 |
Effects of ketoprofen and indomethacin on leukocyte migration in two models of pleurisy induced by carrageenan or zymosan-activated serum in rats.
Topics: Animals; Blood Proteins; Capillary Permeability; Carrageenan; Chemotaxis, Leukocyte; Complement Activation; Indomethacin; Ketoprofen; Male; Phenylpropionates; Pleurisy; Rats; Rats, Inbred Strains; Zymosan | 1989 |
Effects of nonsteroidal antiinflammatory drugs on renal function in patients with renal insufficiency and in cirrhotics.
Topics: Acetates; Anti-Inflammatory Agents, Non-Steroidal; Creatinine; Dinoprostone; Etodolac; Humans; Indomethacin; Ketoprofen; Kidney; Kidney Failure, Chronic; Kidney Function Tests; Liver Cirrhosis, Alcoholic; Prostaglandins E; Sulindac | 1986 |
The history of diclofenac.
Topics: Chemical Phenomena; Chemistry; Diclofenac; Humans; Hydrogen-Ion Concentration; Ibuprofen; Indenes; Indomethacin; Ketoprofen; Naproxen; Phenylbutazone; Piroxicam; Prostaglandin-Endoperoxide Synthases; Structure-Activity Relationship; Thiazines | 1986 |
The properties of solid dispersions of indomethacin, ketoprofen and flurbiprofen in phosphatidylcholine.
Topics: Chemical Phenomena; Chemistry, Pharmaceutical; Chemistry, Physical; Flurbiprofen; Indomethacin; Ketoprofen; Phenylpropionates; Phosphatidylcholines; Powders; Propionates | 1988 |
Effect of cyclohexanone derivatives on percutaneous absorption of ketoprofen and indomethacin.
Topics: Administration, Cutaneous; Animals; Cyclohexanones; Drug Design; Indomethacin; Ketoprofen; Kinetics; Male; Phenylpropionates; Rats; Rats, Inbred Strains; Skin Absorption; Structure-Activity Relationship | 1988 |
Effect of some non-steroidal anti-inflammatory drugs on ouabain-induced arrhythmias in guinea-pigs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arrhythmias, Cardiac; Aspirin; Blood Pressure; Female; Guinea Pigs; Heart Rate; Hemodynamics; Indomethacin; Ketoprofen; Male; Ouabain | 1988 |
Effect of different treatments of the endotoxin-induced modifications in serum iron levels.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Endotoxins; Female; Fever; Indomethacin; Iron; Ketoprofen; Male; Polymyxin B; Rabbits | 1986 |
The effect of cyclooxygenase inhibitors on the low filling rate cystometrogram in urethane anesthetized rats.
Topics: Anesthesia; Animals; Cyclooxygenase Inhibitors; Indomethacin; Ketoprofen; Male; Muscle Contraction; Phenylpropionates; Pressure; Rats; Rats, Inbred Strains; Reflex; Urethane; Urinary Bladder; Urination | 1985 |
The modulation of peritoneal macrophage chemiluminescence by acute pleural inflammation, prostanoids and cyclo/lipoxygenase inhibitors.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Acute Disease; Animals; Catechols; Cyclooxygenase Inhibitors; Dinoprostone; Epoprostenol; Indomethacin; Ketoprofen; Lipoxygenase Inhibitors; Luminescent Measurements; Macrophages; Male; Masoprocol; Peritoneal Cavity; Pleurisy; Prostaglandins; Prostaglandins E; Pyrazoles; Rats; Rats, Inbred Strains | 1985 |
Lack of effect of prostaglandin inhibition on calcium excretion in normal volunteers.
Topics: Adult; Aspirin; Calcium; Creatinine; Humans; Indomethacin; Ketoprofen; Male; Prostaglandin Antagonists; Sodium | 1985 |
Effects of some anti-inflammatory drugs on 12 blood constituents: protocol for the study of in vivo effects of drugs.
Topics: Anti-Inflammatory Agents; Aspirin; Blood Chemical Analysis; Blood Urea Nitrogen; Cholesterol; Creatinine; Diclofenac; Humans; Ibuprofen; Indomethacin; Iron; Ketoprofen; Prospective Studies; Retrospective Studies; Serum Albumin; Time Factors; Triglycerides; Uric Acid | 1985 |
Anti-inflammatory effects of ketoprofen in rabbit corneal epithelial wound model.
Topics: Animals; Ciliary Body; Conjunctiva; Corneal Injuries; Dose-Response Relationship, Drug; Indomethacin; Iris; Ketoprofen; Male; Neutrophils; Phenylpropionates; Prostaglandins E; Rabbits; Tears; Wound Healing | 1985 |
Diclofenac in the treatment of painful joints and traumatic tendinitis (including strains and sprains): a brief review.
Topics: Diclofenac; Flufenamic Acid; Humans; Ibuprofen; Indomethacin; Joint Diseases; Ketoprofen; Naproxen; Pain; Sprains and Strains; Tendinopathy | 1985 |
Effect of arachidonic acid metabolism on the release of histamine and SRS (leukotrienes) from guinea-pig lung.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cysteine; Guinea Pigs; Histamine Release; In Vitro Techniques; Indomethacin; Ketoprofen; Lipoxygenase Inhibitors; Lung; Male; Mast Cells; SRS-A | 1984 |
[Comparative study of platelet anti-aggregation effect of several anti-inflammatory agents].
Topics: Adenosine Diphosphate; Collagen; Cyclic AMP; Epinephrine; Humans; In Vitro Techniques; Indomethacin; Inflammation; Ketoprofen; Phenothiazines; Phenylpropionates; Platelet Aggregation; Prostaglandins | 1983 |
[Action of ketoprofen on hepatic lysosomes in the rat].
Topics: Animals; Arthritis, Experimental; In Vitro Techniques; Indomethacin; Ketoprofen; Liver; Lysosomes; Male; Phenylpropionates; Rats; Rats, Inbred Strains | 1983 |
Effects of cyclooxygenase and lipoxygenase inhibition on lung fluid balance after thrombin.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Cyclooxygenase Inhibitors; Indomethacin; Ketoprofen; Lipoxygenase Inhibitors; Lung; Pyrazoles; Thrombin; Water-Electrolyte Balance | 1983 |
Cyclo-oxygenase inhibitors antagonize indirectly evoked contractions of the guinea-pig isolated ileum by inhibiting acetylcholine release.
Topics: Acetylcholine; Animals; Cyclooxygenase Inhibitors; Dinoprostone; Electric Stimulation; Female; Guinea Pigs; Ileum; In Vitro Techniques; Indomethacin; Ketoprofen; Male; Meclofenamic Acid; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Nicotine; Prostaglandins E; Synaptic Membranes | 1984 |
Evidence for the involvement of arachidonic acid metabolites in spontaneous and drug-induced contractions of rat urinary bladder.
Topics: Adenosine Diphosphate; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Aspirin; Diet; Fatty Acids, Essential; Hexamethonium Compounds; Indomethacin; Ketoprofen; Male; Muscle Contraction; Physostigmine; Piroxicam; Rats; Rats, Inbred Strains; Tetrodotoxin; Thiazines; Urinary Bladder | 1984 |
Poisoning after overdose with non-steroidal anti-inflammatory drugs.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents; Child; Child, Preschool; Diflunisal; Female; Fenoprofen; Feprazone; Humans; Ibuprofen; Indomethacin; Ketoprofen; London; Male; Mefenamic Acid; Naproxen; Oxyphenbutazone; Phenylbutazone; Piroxicam; Thiazines; Tolmetin | 1984 |
Interaction between reserpine and non-steroidal anti-inflammatory agents in producing gastric ulcers in rats.
Topics: Animals; Anti-Inflammatory Agents; Dose-Response Relationship, Drug; Drug Synergism; Female; Indomethacin; Ketoprofen; Phenylbutazone; Rats; Reserpine; Stomach Ulcer | 1984 |
[Inhibitory effect of TN-762 (suprofen) on platelet aggregation].
Topics: Adenosine Diphosphate; Agglutination; Animals; Aorta; Calcium; Collagen; Depression, Chemical; Epoprostenol; In Vitro Techniques; Indomethacin; Ketoprofen; Liposomes; Male; Phenylpropionates; Platelet Aggregation; Rabbits; Rats; Suprofen | 1982 |
Multiple sites on prostaglandin cyclooxygenase are determinants in the action of nonsteroidal antiinflammatory agents.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Cyclooxygenase Inhibitors; Diflunisal; Indomethacin; Ketoprofen; Male; Rats; Salicylates; Stomach Ulcer; Structure-Activity Relationship | 1981 |
Arachidonic acid metabolites and the gastro-intestinal toxicity of anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Aspirin; Cyclooxygenase Inhibitors; Digestive System; Flurbiprofen; Gastric Mucosa; Indomethacin; Intestinal Mucosa; Ketoprofen; Naproxen; Prostaglandins; Rats | 1981 |
Renal papillary necrosis following regular consumption of non-steroidal anti-inflammatory drugs.
Topics: Aged; Anti-Inflammatory Agents; Humans; Ibuprofen; Indomethacin; Ketoprofen; Kidney Papillary Necrosis; Male; Middle Aged; Naproxen; Osteoarthritis | 1982 |
[Evaluation of nonsteroidal anti-inflammatory drugs (NSAID) intended for use as topical anti-inflammatory drugs].
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Edema; Erythema; Guinea Pigs; Indomethacin; Ketoprofen; Ointment Bases; Ointments; Particle Size; Peptic Ulcer; Phenylpropionates; Rats; Solubility | 1982 |
[Distribution of non-steroidal anti-inflammatory agents in human tissues].
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Humans; Indoleacetic Acids; Indomethacin; Ketoprofen; Kinetics; Tissue Distribution | 1982 |
[Trans-placental transfer of four anti-inflammatory agents. A study carried out by in vitro perfusion (author's transl)].
Topics: Anti-Inflammatory Agents; Female; Humans; Indomethacin; Ketoprofen; Oxyphenbutazone; Perfusion; Phenylbutazone; Placenta; Pregnancy | 1981 |
Restoration of postburn impaired lymphocyte responsiveness by nonsteroidal anti-inflammatory drugs is independent of prostaglandin E2 inhibition.
Topics: Administration, Oral; Amino Acid Oxidoreductases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Burns; Dinoprostone; Indomethacin; Ketoprofen; Lymphocyte Activation; Male; Niflumic Acid; Nitric Oxide Synthase; Piroxicam; Rats; Rats, Wistar; Salicylates | 1994 |
Modulation by stereoselective inhibition of cyclo-oxygenase of electromechanical coupling in the guinea-pig isolated renal pelvis.
Topics: Animals; Biomechanical Phenomena; Cyclooxygenase Inhibitors; Electric Stimulation; Evoked Potentials; Guinea Pigs; In Vitro Techniques; Indomethacin; Ketoprofen; Kidney Pelvis; Male; Pacemaker, Artificial; Stereoisomerism; Ureter | 1995 |
Effect of etodolac on prostaglandin E2 biosynthesis, active oxygen generation and bradykinin formation.
Topics: Animals; Aspirin; Bradykinin; Bromelains; Cartilage, Articular; Cell Line; Concanavalin A; Depression, Chemical; Diclofenac; Dinoprostone; Dogs; Etodolac; Gastric Mucosa; Guinea Pigs; Indomethacin; Interleukin-1; Ketoprofen; Kidney; Naproxen; Oxygen; Pain; Piroxicam; Rabbits; Rats | 1994 |
Effect of the low molecular weight heparin/non steroidal anti-inflammatory drugs association on an experimental thrombosis induced by laser.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Drug Therapy, Combination; Indomethacin; Injections, Subcutaneous; Ketoprofen; Lasers; Male; Nadroparin; Piroxicam; Platelet Aggregation; Rats; Rats, Wistar; Thrombolytic Therapy; Thrombosis | 1995 |
Collagenase-induced oedema in the rat paw and the kinin system.
Topics: Animals; Arginine; Azepines; Bradykinin; Collagenases; Edema; Female; Heparin; Hindlimb; Indomethacin; Kallikrein-Kinin System; Ketoprofen; Kininogens; Male; Methysergide; Nitroarginine; Platelet Aggregation Inhibitors; Pyrilamine; Rats; Rats, Wistar; Serine Proteinase Inhibitors; Triazoles | 1995 |
The determination of non-steroidal antiinflammatory drugs in pharmaceuticals by capillary zone electrophoresis and micellar electrokinetic capillary chromatography.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Buffers; Calibration; Chemistry, Pharmaceutical; Chromatography; Diclofenac; Dosage Forms; Electrophoresis; Ibuprofen; Indomethacin; Ketoprofen; Micelles; Piroxicam; Reference Standards; Regression Analysis; Reproducibility of Results | 1994 |
Modelling circadian variation in the pharmacokinetics of non-steroidal anti-inflammatory drugs.
Topics: Adult; Circadian Rhythm; Drug Administration Schedule; Female; Humans; Indomethacin; Ketoprofen; Male; Models, Biological | 1993 |
Nonsteroidal anti-inflammatory drugs differentially regulate cytokine production in human lymphocytes: up-regulation of TNF, IFN-gamma and IL-2, in contrast to down-regulation of IL-6 production.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Base Sequence; Cells, Cultured; Clone Cells; Diclofenac; Dinoprostone; Gene Expression Regulation; HTLV-I Infections; Humans; Indomethacin; Interferon-gamma; Interleukin-2; Interleukin-6; Ketoprofen; Leukemia-Lymphoma, Adult T-Cell; Leukocytes, Mononuclear; Lymphocyte Activation; Molecular Sequence Data; Polymerase Chain Reaction; RNA, Messenger; Sarcoidosis, Pulmonary; T-Lymphocyte Subsets; Th1 Cells; Th2 Cells; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Uveitis | 1995 |
Application of chemical cytochrome P-450 model systems to studies on drug metabolism--VIII. Novel metabolism of carboxylic acids via oxidative decarboxylation.
Topics: Animals; Bile; Carbon Dioxide; Carboxylic Acids; Cytochrome P-450 Enzyme System; Decarboxylation; Electron Spin Resonance Spectroscopy; Ferric Compounds; In Vitro Techniques; Indomethacin; Iodobenzenes; Ketoprofen; Magnetic Resonance Spectroscopy; Male; Metalloporphyrins; Microsomes, Liver; Oxidation-Reduction; Phenylacetates; Platelet Aggregation Inhibitors; Rabbits; Rats; Rats, Wistar | 1995 |
Induction of cytochrome P-450 BM-3 (CYP 102) by non-steroidal anti-inflammatory drugs in Bacillus megaterium.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bacillus megaterium; Bacterial Proteins; Base Sequence; Cytochrome P-450 Enzyme System; Enzyme Induction; Gene Expression; Ibuprofen; Indomethacin; Ketoprofen; Kinetics; Mammals; Mixed Function Oxygenases; Molecular Sequence Data; NADPH-Ferrihemoprotein Reductase; Oligodeoxyribonucleotides; Repressor Proteins; Transcription Factors | 1996 |
Antinociceptive activity of a novel non-steroidal anti-inflammatory drug (M-5011) with low ulcerogenic effects in mice.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Bradykinin; Dose-Response Relationship, Drug; Gastric Mucosa; Indomethacin; Intestinal Mucosa; Kaolin; Ketoprofen; Linear Models; Male; Mice; Mice, Inbred ICR; Pain Measurement; Phenylpropionates; Propionates | 1996 |
Simultaneous activation of granulocytes and extrathymic T cells in number and function by excessive administration of nonsteroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Autoimmunity; Bone Marrow; Bone Marrow Cells; Cytotoxicity, Immunologic; Dose-Response Relationship, Drug; Granulocytes; Indomethacin; Ketoprofen; Liver; Lymphocyte Activation; Mice; Mice, Inbred C3H; Nitric Oxide Synthase; RNA, Messenger; T-Lymphocytes; Thymus Gland | 1996 |
Rapid, sensitive and direct chiral high-performance liquid chromatographic method for ketoprofen enantiomers.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Humans; Indomethacin; Ketoprofen; Linear Models; Rats; Reference Standards; Sensitivity and Specificity; Stereoisomerism | 1996 |
Effects of intrathecal or intracerebroventricular administration of nonsteroidal anti-inflammatory drugs on a C-fiber reflex in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dose-Response Relationship, Drug; Indomethacin; Injections, Intraventricular; Injections, Spinal; Ketoprofen; Male; Nerve Fibers; Rats; Rats, Sprague-Dawley; Reflex | 1997 |
Histamine H2-receptor antagonist action of ebrotidine. Effects on gastric acid secretion, gastrin levels and NSAID-induced gastrotoxicity in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzenesulfonates; Diclofenac; Dose-Response Relationship, Drug; Female; Gastric Acid; Gastrins; Guinea Pigs; Heart Atria; Heart Rate; Histamine; Histamine H2 Antagonists; In Vitro Techniques; Indomethacin; Ketoprofen; Male; Naproxen; Pentagastrin; Ranitidine; Rats; Rats, Sprague-Dawley; Rats, Wistar; Thiazoles | 1997 |
The effects of a newly developed nonsteroidal anti-inflammatory drug (M-5011) on arachidonic acid metabolism in rheumatoid synovial fibroblasts.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arthritis, Rheumatoid; Bradykinin; Carbon Radioisotopes; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Female; Fibroblasts; Humans; Indomethacin; Interleukin-1; Isoenzymes; Ketoprofen; Membrane Proteins; Middle Aged; Phenylpropionates; Prostaglandin-Endoperoxide Synthases; Synovial Membrane | 1997 |
Nonsteroidal antiinflammatory drug-photosensitized formation of pyrimidine dimer in DNA.
Topics: Anti-Inflammatory Agents, Non-Steroidal; DNA; DNA Damage; DNA, Single-Stranded; Energy Transfer; In Vitro Techniques; Indomethacin; Ketoprofen; Naproxen; Photochemistry; Photosensitizing Agents; Propionates; Pyrimidine Dimers | 1998 |
Anti-inflammatory, analgesic and anti-pyretic effects of d-2-[4-(3-methyl-2-thienyl)phenyl]propionic acid (M-5011), a new non-steroidal anti-inflammatory drug, in rats and guinea pigs.
Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Diclofenac; Dinoprostone; Edema; Erythema; Fever; Gastric Mucosa; Guinea Pigs; Hindlimb; Hyperalgesia; Indomethacin; Intestinal Mucosa; Ketoprofen; Male; Phenylpropionates; Rats; Species Specificity; Stomach Ulcer; Ultraviolet Rays | 1998 |
Effect of one-month treatment with nonsteroidal antiinflammatory drugs (NSAIDs) on gastric pH of rheumatoid arthritis patients.
Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Case-Control Studies; Circadian Rhythm; Female; Gastric Acid; Gastric Acidity Determination; Humans; Hydrogen-Ion Concentration; Indomethacin; Ketoprofen; Male; Middle Aged; Monitoring, Ambulatory; Peptic Ulcer; Time Factors | 1998 |
Prodrugs. Part 3. 2-Formylphenyl esters of indomethacin, ketoprofen and ibuprofen and 6-substituted 2-formyl and 2-acylphenyl esters of aspirin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Ibuprofen; Indomethacin; Ketoprofen; Male; Prodrugs; Rats; Rats, Wistar | 1998 |
Arterially perfused eye model of uveitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cats; Ciliary Arteries; Clonixin; Complement C5a; Disease Models, Animal; Dogs; Eye; Female; Histamine; Horse Diseases; Horses; Hydrogen Peroxide; Indomethacin; Intraocular Pressure; Ketoprofen; Male; Perfusion; Pyridones; Uveitis | 1999 |
In vitro effects of nonsteroidal anti-inflammatory agents and prostaglandins I2, E2, and F2alpha on contractility of taenia of the large colon of horses.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbazoles; Clonixin; Colon; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; Epoprostenol; Horses; Indomethacin; Ketoprofen; Muscle Contraction; Muscle, Smooth; Phenylbutazone; Prostaglandins | 1999 |
Uptake of ibuprofen, indomethacin and ketoprofen into isolated rabbit parietal cells.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cold Temperature; Hydrogen-Ion Concentration; Ibuprofen; Indomethacin; Ketoprofen; Male; Parietal Cells, Gastric; Rabbits | 2000 |
Effect of fatty acid Esters on permeation of ketoprofen through hairless rat skin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Esters; Fatty Acids; Indomethacin; Ketoprofen; Male; Rats; Skin Absorption; Solubility | 2000 |
Determination of nonsteroidal anti-inflammatory drugs in biological fluids by automatic on-line integration of solid-phase extraction and capillary electrophoresis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Automation; Chromatography, Micellar Electrokinetic Capillary; Humans; Ibuprofen; Indomethacin; Ketoprofen; Phenylbutyrates; Tolmetin | 2001 |
Determination of diclofenac sodium, flufenamic acid, indomethacin and ketoprofen by LC-APCI-MS.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Capsules; Chromatography, High Pressure Liquid; Diclofenac; Flufenamic Acid; Indomethacin; Ketoprofen; Mass Spectrometry; Sensitivity and Specificity; Tablets | 2001 |
Molecular modelling of the differential interaction between several non-steroidal anti-inflammatory drugs and human prostaglandin endoperoxide H synthase-2 (h-PGHS-2).
Topics: Anti-Inflammatory Agents, Non-Steroidal; Computer Graphics; Computer Simulation; Crystallography, X-Ray; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Energy Transfer; Flurbiprofen; Humans; Indomethacin; Isoenzymes; Ketoprofen; Meclofenamic Acid; Mefenamic Acid; Membrane Proteins; Models, Molecular; Naproxen; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides | 2002 |
Eosinophilic pustular folliculitis (Ofuji's disease) in Singapore: a review of 23 adult cases.
Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Cheek; Dapsone; Eosinophilia; Facial Dermatoses; Female; Folliculitis; Humans; Indomethacin; Ketoprofen; Male; Medical Records; Middle Aged; Retrospective Studies; Singapore | 2003 |
Investigation of the release behavior of a covered-rod-type formulation using silicone.
Topics: Antipyrine; Delayed-Action Preparations; Deoxycholic Acid; Drug Carriers; Drug Compounding; Indomethacin; Ketoprofen; Powders; Serum Albumin, Bovine; Silicones; Solubility; Surface-Active Agents | 2003 |
Antinociceptive synergy, additivity, and subadditivity with combinations of oral glucosamine plus nonopioid analgesics in mice.
Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diclofenac; Disease Models, Animal; Drug Therapy, Combination; Glucosamine; Ibuprofen; Indomethacin; Ketoprofen; Mice; Pain; Piroxicam | 2003 |
In vitro investigation of the effects of nonsteroidal anti-inflammatory drugs, prostaglandin E2, and prostaglandin F2alpha on contractile activity of the third compartment of the stomach of llamas.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Butanones; Camelids, New World; Dinoprost; Dinoprostone; In Vitro Techniques; Indomethacin; Ketoprofen; Muscle Contraction; Nabumetone; Stomach | 2004 |
Amphiphilic star-like macromolecules as novel carriers for topical delivery of nonsteroidal anti-inflammatory drugs.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemistry, Pharmaceutical; Drug Carriers; Drug Delivery Systems; Female; Indomethacin; Ketoprofen; Macromolecular Substances; Male; Mice; Permeability; Piroxicam; Skin Absorption | 2003 |
Effects of NSAIDs on bladder function in normal and cystitis rats: a comparison study of aspirin, indomethacin, and ketoprofen.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclophosphamide; Cystitis; Female; Gastric Mucosa; Indomethacin; Ketoprofen; Muscle Contraction; Muscle, Smooth; Peptic Ulcer; Prostaglandins; Rats; Rats, Sprague-Dawley; Urinary Bladder | 2004 |
Regioselective enzymatic synthesis of non-steroidal anti-inflammatory drugs containing glucose in organic media.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Bacillus subtilis; Bacterial Proteins; Candida; Catalysis; Chromatography, Thin Layer; Endopeptidases; Glucose; Indomethacin; Ketoprofen; Lipase | 2005 |
Drug encapsulation using supercritical fluid extraction of emulsions.
Topics: Acetates; Acrylic Resins; Carbon Dioxide; Chromatography, Supercritical Fluid; Drug Compounding; Emulsions; Indomethacin; Ketoprofen; Lactic Acid; Microspheres; Nanostructures; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers | 2006 |
Hydrophilic absorbable copolyester exhibiting zero-order drug release.
Topics: Absorption; Anti-Inflammatory Agents, Non-Steroidal; Delayed-Action Preparations; Diclofenac; Excipients; Hydrolysis; Indicators and Reagents; Indomethacin; Ketoprofen; Lactic Acid; Lactones; Polyethylenes; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis; Water | 2006 |
Dual, but not selective, COX-1 and COX-2 inhibitors, attenuate acetic acid-evoked bladder irritation in the anaesthetised female cat.
Topics: Acetic Acid; Anesthesia; Animals; Cats; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Female; Indomethacin; Ketoprofen; Male; Nitrobenzenes; Piperazines; Reflex, Abnormal; Sodium Chloride; Sulfonamides; Thiazoles; Urinary Bladder Diseases | 2006 |
Biocompatibility and drug release behavior of spontaneously formed phospholipid polymer hydrogels.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibiotics, Antineoplastic; Antimetabolites; Biocompatible Materials; Delayed-Action Preparations; Doxorubicin; Fluorouracil; Humans; Hydrogels; Indomethacin; Ketoprofen; Male; Materials Testing; Methacrylates; Phosphorylcholine; Rats; Rats, Sprague-Dawley | 2007 |
Design of original bioactive formulations based on sugar-surfactant/non-steroidal anti-inflammatory catanionic self-assemblies: a new way of dermal drug delivery.
Topics: Administration, Topical; Animals; Anions; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Cations; Drug Carriers; Drug Delivery Systems; Drug Design; Ear; Edema; Ibuprofen; Indomethacin; Ketoprofen; Male; Mice; Permeability; Pharmaceutical Preparations; Skin Absorption; Surface-Active Agents; Swine | 2007 |
Determination of non-steroidal anti-inflammatory drugs in urine by combining an immobilized carboxylated carbon nanotubes minicolumn for solid-phase extraction with capillary electrophoresis-mass spectrometry.
Topics: Adsorption; Anti-Inflammatory Agents, Non-Steroidal; Carboxylic Acids; Electrophoresis, Capillary; Hydrogen-Ion Concentration; Indomethacin; Ketoprofen; Methanol; Nanotubes, Carbon; Sensitivity and Specificity; Solid Phase Extraction; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tolmetin; Urine | 2007 |
Production of solid lipid nanoparticle suspensions using supercritical fluid extraction of emulsions (SFEE) for pulmonary delivery using the AERx system.
Topics: Administration, Inhalation; Aerosols; Chromatography, Supercritical Fluid; Dosage Forms; Drug Delivery Systems; Drug Stability; Emulsions; Indomethacin; Ketoprofen; Lipids; Nanoparticles; Particle Size; Solubility; Suspensions | 2007 |
Possible involvement of 5-lipoxygenase metabolite in itch-associated response of mosquito allergy in mice.
Topics: Animals; Arachidonate 5-Lipoxygenase; Betamethasone Valerate; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Chromones; Cimetidine; Culicidae; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Hydrazines; Hydroxyurea; Hypersensitivity; Indoles; Indomethacin; Ketoprofen; Leukotriene B4; Lipoxygenase Inhibitors; Male; Mice; Mice, Inbred ICR; NG-Nitroarginine Methyl Ester; Phenylpropionates; Phospholipid Ethers; Propionates; Pruritus; Quinolines; Terfenadine | 2007 |
Reactive oxygen species mediate detrusor overactivity via sensitization of afferent pathway in the bladder of anaesthetized rats.
Topics: Afferent Pathways; Animals; Antioxidants; Capsaicin; Catalase; Cyclooxygenase Inhibitors; Deferoxamine; Dose-Response Relationship, Drug; Female; Free Radical Scavengers; Hydrogen Peroxide; Indomethacin; Ketoprofen; Prostaglandins; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Sensory System Agents; Siderophores; Superoxide Dismutase; Thiourea; Urinary Bladder; Urinary Bladder, Overactive; Urination | 2008 |
Effect of O-acylmenthol on transdermal delivery of drugs with different lipophilicity.
Topics: Acids, Carbocyclic; Administration, Cutaneous; Animals; Chemistry, Pharmaceutical; Cinnamates; Diffusion Chambers, Culture; Drug Compounding; Fluorouracil; Hydrolysis; Indomethacin; Isosorbide Dinitrate; Ketoprofen; Kinetics; Lactates; Lidocaine; Male; Menthol; Oleic Acids; Permeability; Pharmaceutical Preparations; Rats; Rats, Wistar; Salicylates; Skin; Skin Absorption; Technology, Pharmaceutical | 2008 |
Transdermal delivery of penetrants with differing lipophilicities using O-acylmenthol derivatives as penetration enhancers.
Topics: Administration, Cutaneous; Animals; Chemistry, Pharmaceutical; Fatty Acids; Fluorouracil; Indomethacin; Isosorbide Dinitrate; Ketoprofen; Lidocaine; Male; Menthol; Rats; Rats, Wistar; Skin Absorption; Technology, Pharmaceutical | 2008 |
Analgesic effect of percutaneously absorbed non-steroidal anti-inflammatory drugs: an experimental study in a rat acute inflammation model.
Topics: Acute Disease; Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Contusions; Dinoprostone; Indomethacin; Inflammation; Ketoprofen; Male; Pain; Pain Threshold; Phenylacetates; Phenylpropionates; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Sprains and Strains | 2008 |
Ionic liquid-based dynamic liquid-phase microextraction: application to the determination of anti-inflammatory drugs in urine samples.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemical Fractionation; Flurbiprofen; Humans; Hydrogen-Ion Concentration; Indomethacin; Ionic Liquids; Ketoprofen; Molecular Structure; Naproxen; Phenylbutyrates; Reproducibility of Results; Tolmetin | 2008 |
Removal of selected pharmaceuticals by chlorination, coagulation-sedimentation and powdered activated carbon treatment.
Topics: Antipyrine; Charcoal; Clofibric Acid; Diclofenac; Fenoprofen; Gemfibrozil; Halogenation; Ibuprofen; Indomethacin; Ketoprofen; Naproxen; Water Pollutants, Chemical; Water Purification; Water Supply | 2008 |
Inhibitory effect of nonsteroidal anti-inflammatory drugs on adenosine transport in vascular smooth muscle cells.
Topics: Adenosine; Anti-Inflammatory Agents, Non-Steroidal; Aorta; Cell Proliferation; Cells, Cultured; Coloring Agents; Dose-Response Relationship, Drug; Etodolac; Humans; Indomethacin; Inhibitory Concentration 50; Ketoprofen; Kinetics; Mefenamic Acid; Muscle, Smooth, Vascular; Piroxicam; Sulindac; Temperature; Tetrazolium Salts; Thiazoles; Thioinosine | 2009 |
Quantifying drug release from PLGA nanoparticulates.
Topics: Algorithms; Anti-Inflammatory Agents, Non-Steroidal; Delayed-Action Preparations; Diffusion; Excipients; Indomethacin; Ketoprofen; Lactic Acid; Microscopy, Electron, Scanning; Models, Statistical; Molecular Weight; Nanoparticles; Particle Size; Pharmaceutical Preparations; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Serum Albumin; Solubility | 2009 |
Glucose promoiety enables glucose transporter mediated brain uptake of ketoprofen and indomethacin prodrugs in rats.
Topics: Animals; Biological Transport; Blood-Brain Barrier; Brain; Drug Delivery Systems; Glucose; Glucose Transport Proteins, Facilitative; Indomethacin; Ketoprofen; Prodrugs; Rats | 2009 |
Phase behavior of ketoprofen-poly(lactic acid) drug particles formed by rapid expansion of supercritical solutions.
Topics: Indomethacin; Ketoprofen; Kinetics; Lactic Acid; Microscopy, Electron, Scanning; Naproxen; Polyesters; Polymers; Solutions; Spectrophotometry, Infrared | 2010 |
Differential involvement of mitochondrial dysfunction, cytochrome P450 activity, and active transport in the toxicity of structurally related NSAIDs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; ATP-Binding Cassette Transporters; Biological Transport, Active; Cytochrome P-450 Enzyme System; Diclofenac; Electron Transport; Genes, MDR; Ibuprofen; Indomethacin; Ketoprofen; Ketorolac; Mitochondria; Naproxen; Reactive Oxygen Species; Sulindac; Tolmetin; Yeasts | 2012 |
Determination of non-steroidal anti-inflammatory drugs in urine by the combination of stir membrane liquid-liquid-liquid microextraction and liquid chromatography.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chromatography, Liquid; Flurbiprofen; Humans; Indomethacin; Ketoprofen; Limit of Detection; Liquid Phase Microextraction; Naproxen | 2012 |
Effect of ketoprofen and indomethacin on methotrexate pharmacokinetics in mice plasma and tumor tissues.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites, Antineoplastic; Area Under Curve; Carcinoma, Ehrlich Tumor; Chromatography, High Pressure Liquid; Drug Interactions; Female; Half-Life; Indomethacin; Injections, Intraperitoneal; Ketoprofen; Metabolic Clearance Rate; Methotrexate; Mice; Multidrug Resistance-Associated Proteins | 2013 |
Bacterial β-glucuronidase inhibition protects mice against enteropathy induced by indomethacin, ketoprofen or diclofenac: mode of action and pharmacokinetics.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, Liquid; Diclofenac; Enzyme Inhibitors; Glucuronidase; Hepatocytes; Indomethacin; Intestinal Diseases; Intestine, Small; Ketoprofen; Male; Mice; Mice, Inbred C57BL; Quinolones; Statistics, Nonparametric; Tandem Mass Spectrometry; Thiourea | 2014 |
In vivo predictive dissolution: transport analysis of the CO2 , bicarbonate in vivo buffer system.
Topics: Bicarbonates; Buffers; Carbon Dioxide; Chemistry, Pharmaceutical; Diffusion; Equipment Design; Hydrogen-Ion Concentration; Ibuprofen; Indomethacin; Ketoprofen; Kinetics; Models, Chemical; Solubility; Technology, Pharmaceutical | 2014 |
Role of simplex lattice statistical design in the formulation and optimization of microemulsions for transdermal delivery.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Carriers; Drug Delivery Systems; Elapidae; Emulsions; Ethanol; Hydrogen-Ion Concentration; Indomethacin; Ketoprofen; Models, Statistical; Oleic Acid; Permeability; Polyethylene Glycols; Skin Absorption | 2014 |
Pharmacological Characterization of the Edema Caused by Vitalius dubius (Theraphosidae, Mygalomorphae) Spider Venom in Rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Cyproheptadine; Dose-Response Relationship, Drug; Edema; Foot; Histamine H1 Antagonists; Indomethacin; Ketoprofen; Male; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-2; Serotonin Antagonists; Skin; Spider Venoms | 2016 |
Diets with no or low amounts of dietary fiber can reduce small intestinal ulcers induced by non-steroidal anti-inflammatory drugs in dogs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cellulose; Dietary Fiber; Dietary Supplements; Dogs; Female; Indomethacin; Intestinal Diseases; Intestine, Small; Ketoprofen; Male; Pectins; Stomach; Stomach Diseases; Ulcer | 2016 |
Non-steroidal anti-inflammatory drugs in the watercourses of Elbe basin in Czech Republic.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Czech Republic; Diclofenac; Environmental Monitoring; Gas Chromatography-Mass Spectrometry; Ibuprofen; Indomethacin; Ketoprofen; Naproxen; Rivers; Water Pollutants, Chemical | 2017 |
Effect of Ketoprofen and ATB-352 on the Immature Human Intestine: Identification of Responders and Non-responders.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Humans; Indomethacin; Intestine, Small; Ketoprofen; Signal Transduction | 2019 |
Ketoprofen, piroxicam and indomethacin-suppressed quorum sensing and virulence factors in Acinetobacter baumannii.
Topics: Acinetobacter baumannii; Anti-Bacterial Agents; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Biofilms; Chromobacterium; Hydrogen; Indomethacin; Ketoprofen; Molecular Docking Simulation; Piroxicam; Quorum Sensing; Virulence Factors | 2022 |
An Evolving Role of Aqueous Piperazine to Improve the Solubility of Non-Steroidal Anti-Inflammatory Drugs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Calorimetry, Differential Scanning; Flurbiprofen; Ibuprofen; Indomethacin; Ketoprofen; Phenylbutazone; Piperazine; Powders; Salts; Solubility; Spectroscopy, Fourier Transform Infrared; Sulindac; Water; X-Ray Diffraction | 2022 |