ketoprofen and flurbiprofen

ketoprofen has been researched along with flurbiprofen in 94 studies

Research

Studies (94)

TimeframeStudies, this research(%)All Research%
pre-199010 (10.64)18.7374
1990's17 (18.09)18.2507
2000's33 (35.11)29.6817
2010's28 (29.79)24.3611
2020's6 (6.38)2.80

Authors

AuthorsStudies
Apiwattanakul, N; Chairoungdua, A; Endou, H; Kanai, Y; Nakajima, N; Sekine, T; Sophasan, S1
Duffy, EM; Jorgensen, WL1
Topliss, JG; Yoshida, F1
Cihlar, T; Ho, ES; Mulato, AS1
Borst, P; de Haas, M; Kuil, A; Reid, G; van der Heijden, I; Wielinga, P; Wijnholds, J; Zelcer, N1
Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P1
Chang, TK; Ensom, MH; Kiang, TK1
Anacardio, R; Aureli, L; Cesta, MC; Cruciani, G; De Simone, L; Moriconi, A1
Caron, G; Ermondi, G1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Carrupt, PA; Martel, S; Ottaviani, G1
Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM1
Abellán Guillén, A; Cordeiro, MN; Garrido Escudero, A; Morales Helguera, A; Pérez-Garrido, A1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Gozalbes, R; Pineda-Lucena, A1
Ekins, S; Williams, AJ; Xu, JJ1
Fujiwara, R; Koga, T; Nakajima, M; Yokoi, T1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K1
Caradonna, NP; Hallifax, D; Houston, JB; Turlizzi, E; Zanelli, U1
Kumar, M; Sinha, VR; Thareja, S1
Bellman, K; Knegtel, RM; Settimo, L1
Headey, SJ; Hughes, ML; Laguerre, A; Mohanty, B; Patil, R; Porter, CJ; Scanlon, MJ; Wielens, J; Williams, ML1
Brewster, C; Deering-Rice, CE; Reilly, CA; Rose, TM1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL1
Anderson, JA; Buchanan, WW; Lee, P; Miller, J; Webb, J1
Mushin, A; Williams, H; Zutshi, D1
Ho, C; Hwang, GC1
Brune, K; Geisslinger, G; Menzel-Soglowek, S; Mollenhauer, J1
Fritz, ME; Green, MD; Mayambala, CS; Odle, BM; Offenbacher, S; Sena, FJ; Smith, MA; van Dyke, TE; Yeh, KC1
Blessington, B; Crabb, N; Karkee, S; Northage, A1
Borisiuk, BE; Bulakh, EP; Levin, IV; Perepel'chenko, AI; Ternovoĭ, NK1
Fujii, M; Matsumoto, M; Mori, T; Sawada, Y; Terai, H1
Berry, BW; Jamali, F1
Chiba, K; Higuchi, N; Kikuchi, S; Miyazaki, S; Nishimura, S; Takada, M1
Capell, HA; Hunter, JA; Madhok, R; Pullar, T; Zoma, AA1
Cherubino, P; Longoni, A1
Whittle, BJ1
Cicala, C; Cirino, G; Grisham, MB; McKnight, W; Reuter, B; Wallace, JL1
Bradley, JD; Brater, DC; Greene, PK; Tracy, TS; Worster, T1
Brune, K; Geisslinger, G; Menzel-Soglowek, S1
Beck, WS; Brune, K; Geisslinger, G; Menzel, S1
Baydoun, AR; Cirino, G; Del Soldato, P; Wallace, JL; Wheeler-Jones, CP1
Cabré, F; Carabaza, A; García, ML; Gómez, M; Gutiérrez, M; Mauleón, D; Rotllan, E1
Davies, NM; Jamali, F; Russell, AS; Wright, MR1
Feron, VJ; Groene, EM; Horbach, GJ; Kappers, WA; Kleij, LA; Witkamp, RF; Zweers-Zeilmaker, WM1
Borgå, B; Borgå, O1
Caubet, JF; Handley, DA; Jerussi, TP; McCray, JE1
Hubbard, JW; McKay, G; Midha, KK; Rawson, MJ1
el-Bary, AA; el-Nabarawi, MA; Mohamed, MI1
Cabré, F; Díaz, I; Fernández-Guasti, A; López-Muñoz, FJ; Mauleón, D; Tost, D; Ventura, R1
Allegretti, M; Bertini, R; Biordi, L; Caselli, G; Martinotti, S; Marullo, A; Mascagni, P; Sabbatini, V1
Bannwarth, B; Jarry, C; Péhourcq, F1
Cabré, F; Holzer, P; Jocic, M; Mauléon, D1
Lozano, JJ; Pouplana, R; Ruiz, J1
Abushoffa, AM; Crommen, J; Fillet, M; Hubert, P; Servais, AC1
Bateman, SD; Erck, R; Li, T; Morris, KR; Wang, JJ1
Goto, J; Kim, J; Kim, JH; Kim, KR; La, S1
Bateman, SD; Guillot, MA; Morris, KR; Wang, JJ1
Kobayashi, D; Kogo, T; Morimoto, Y; Numajiri, S; Shimamura, T; Tairabune, T; Ueda, H1
Bagheri, H; Lacroix, I; Lapeyre-Mestre, M; Montastruc, JL; Pathak, A1
Kim, KR; Nguyen, DT; Paik, MJ1
Chikamatsu, N; Igarashi, T; Nagata, O; Nakazawa, T; Shimo, T; Yamamoto, M1
Avondo, S; Cardile, V; Garufi, F; Gentile, B; Panico, AM; Ronsisvalle, S1
Balchen, M; Gjelstad, A; Pedersen-Bjergaard, S; Rasmussen, KE1
De Simone, C; Famularo, G; Minisola, G; Nicotra, GC1
Jin, YX; Tang, YH; Zeng, S1
Cárdenas, S; Cruz-Vera, M; Lucena, R; Valcárcel, M1
Fanali, S; Rocco, A1
Angeletti, M; Censi, R; Di Martino, P; Gashi, Z; Gobetto, R; Malaj, L; Masic, A; Mozzicafreddo, M1
Higashi, K; Ideura, S; Moribe, K; Waraya, H; Yamamoto, K1
Goi, N; Ishii, T; Morishita, K; Saitoh, K; Taniguchi, A1
Alcudia-León, MC; Cárdenas, S; Lucena, R; Riaño, S; Valcárcel, M1
Bouchet, LM; de la Guardia, M; Delgado-Pérez, T; Galian, RE; Pérez-Prieto, J1
Gaš, B; Riesová, M; Svobodová, J; Tošner, Z; Ušelová, K; Zusková, I1
Gjelstad, A; Pedersen-Bjergaard, S; Roldán-Pijuán, M1
Higashi, K; Liu, N; Moribe, K; Ueda, K1
Hachuła, B1
Canotilho, J; Castro, RAE; Eusébio, MES; Machado, SMT; Maria, TMR1
Iwaki, M; Kawase, A; Kobayashi, Y; Ogiso, T; Shimada, H; Tanahashi, S1
Ask, KS; Gjelstad, A; Pedersen-Bjergaard, S; Øiestad, EL1
Fukumoto, A; Hori, M; Kaku, S; Matsumoto, H; Tajima, K; Toda, Y1
Alshana, U; Hassan, M1
Chen, Q; Lin, F; Lu, X; Wang, B; Wu, W; Yang, X; Ye, F; Zhao, S1
Carrasco-Correa, EJ; Giesbers, M; Herrero-Martínez, JM; Simó-Alfonso, EF1
Barlow, DJ; Jackson, PJM; Pysz, I; Rahman, KM; Thurston, DE1
Chaturvedi, K; Dave, RH; Morris, KR; Shah, HS1
Bădulescu, M; Stefan-van Staden, RI; Ţuchiu, BM; van Staden, JF1
Du, G; Fang, Z; Gong, N; Lu, Y; Xing, C; Xing, W; Yu, H; Zhang, B1
Gorenflo, M; Saur, P; van den Anker, JN; van Dyk, M; Welzel, T; Ziesenitz, VC1

Reviews

4 review(s) available for ketoprofen and flurbiprofen

ArticleYear
UDP-glucuronosyltransferases and clinical drug-drug interactions.
    Pharmacology & therapeutics, 2005, Volume: 106, Issue:1

    Topics: Clinical Trials as Topic; Drug Interactions; Enzyme Activation; Enzyme Induction; Glucuronides; Glucuronosyltransferase; Humans; Pharmaceutical Preparations; Pharmacogenetics; Polymorphism, Genetic

2005
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
The impact of stereoisomerism in bioequivalence studies.
    Journal of pharmaceutical sciences, 1998, Volume: 87, Issue:7

    Topics: Adrenergic Uptake Inhibitors; Animals; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-Steroidal; Doxepin; Flurbiprofen; Humans; Hydroxychloroquine; Ketoprofen; Nadolol; Nortriptyline; Propafenone; Stereoisomerism; Therapeutic Equivalency

1998
Efficacy and Safety of NSAIDs in Infants: A Comprehensive Review of the Literature of the Past 20 Years.
    Paediatric drugs, 2022, Volume: 24, Issue:6

    Topics: Adolescent; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Child; Chronic Disease; Diclofenac; Flurbiprofen; Humans; Ibuprofen; Infant; Ketoprofen; Ketorolac; Meloxicam; Naproxen; Niflumic Acid; Pain

2022

Trials

5 trial(s) available for ketoprofen and flurbiprofen

ArticleYear
Evaluation of analgesic action and efficacy of antirheumatic drugs. Study of 10 drugs in 684 patients with rheumatoid arthritis.
    The Journal of rheumatology, 1976, Volume: 3, Issue:3

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Flurbiprofen; Humans; Ibuprofen; Indomethacin; Ketoprofen; Mefenamic Acid; Pain; Phenylacetates; Placebos; Prednisone; Salicylates

1976
[Use of flugalin and profenid in patients with rheumatoid arthritis].
    Vrachebnoe delo, 1988, Issue:6

    Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Clinical Trials as Topic; Female; Flurbiprofen; Humans; Ketoprofen; Male; Middle Aged; Phenylpropionates; Propionates

1988
Have the newer NSAIDS contributed to the management of rheumatoid arthritis?
    Scottish medical journal, 1985, Volume: 30, Issue:3

    Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Blood Sedimentation; Feprazone; Flurbiprofen; Humans; Ketoprofen; Patient Dropouts; Phenylbutyrates; Propionates; Random Allocation

1985
Methotrexate disposition following concomitant administration of ketoprofen, piroxicam and flurbiprofen in patients with rheumatoid arthritis.
    British journal of clinical pharmacology, 1994, Volume: 37, Issue:5

    Topics: Administration, Oral; Adult; Aged; Arthritis, Rheumatoid; Drug Interactions; Drug Therapy, Combination; Female; Fluorescence Polarization Immunoassay; Flurbiprofen; Humans; Ketoprofen; Male; Metabolic Clearance Rate; Methotrexate; Middle Aged; Piroxicam

1994
Clinical endoscopic evaluation of the gastroduodenal tolerance to (R)- ketoprofen, (R)- flurbiprofen, racemic ketoprofen, and paracetamol: a randomized, single-blind, placebo-controlled trial.
    Journal of clinical pharmacology, 1998, Volume: 38, Issue:2S

    Topics: Acetaminophen; Adolescent; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Duodenal Diseases; Duodenal Ulcer; Endoscopy, Gastrointestinal; Flurbiprofen; Gastrointestinal Hemorrhage; Humans; Ketoprofen; Male; Middle Aged; Placebos; Single-Blind Method; Stereoisomerism; Stomach Diseases; Stomach Ulcer

1998

Other Studies

85 other study(ies) available for ketoprofen and flurbiprofen

ArticleYear
Transport properties of nonsteroidal anti-inflammatory drugs by organic anion transporter 1 expressed in Xenopus laevis oocytes.
    Molecular pharmacology, 1999, Volume: 55, Issue:5

    Topics: Animals; Anion Transport Proteins; Anti-Inflammatory Agents, Non-Steroidal; Biological Transport; Carrier Proteins; Oocytes; Xenopus laevis

1999
Prediction of drug solubility from Monte Carlo simulations.
    Bioorganic & medicinal chemistry letters, 2000, Jun-05, Volume: 10, Issue:11

    Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility

2000
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Nonsteroidal anti-inflammatory drugs efficiently reduce the transport and cytotoxicity of adefovir mediated by the human renal organic anion transporter 1.
    The Journal of pharmacology and experimental therapeutics, 2000, Volume: 295, Issue:1

    Topics: Adenine; Anion Transport Proteins; Anti-Inflammatory Agents, Non-Steroidal; Antiviral Agents; Biological Transport; Carrier Proteins; Humans; Kidney; Organophosphonates; Structure-Activity Relationship

2000
The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs.
    Proceedings of the National Academy of Sciences of the United States of America, 2003, Aug-05, Volume: 100, Issue:16

    Topics: Adenosine Triphosphate; Alprostadil; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Transport; Cell Line; Cell Membrane; Diffusion; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Humans; Insecta; Multidrug Resistance-Associated Proteins; Prostaglandins; Prostaglandins A; Prostaglandins F; Ribosomal Proteins; RNA Interference; RNA, Small Interfering; Thromboxane B2; Time Factors

2003
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability.
    Journal of medicinal chemistry, 2004, Mar-25, Volume: 47, Issue:7

    Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties

2004
Predicting human serum albumin affinity of interleukin-8 (CXCL8) inhibitors by 3D-QSPR approach.
    Journal of medicinal chemistry, 2005, Apr-07, Volume: 48, Issue:7

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Chemical Phenomena; Chemistry, Physical; Humans; In Vitro Techniques; Interleukin-8; Models, Molecular; Phenylpropionates; Protein Binding; Quantitative Structure-Activity Relationship; Serum Albumin; Stereoisomerism

2005
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
    Journal of medicinal chemistry, 2005, May-05, Volume: 48, Issue:9

    Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water

2005
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
In silico and in vitro filters for the fast estimation of skin permeation and distribution of new chemical entities.
    Journal of medicinal chemistry, 2007, Feb-22, Volume: 50, Issue:4

    Topics: Humans; Membranes, Artificial; Models, Biological; Models, Molecular; Octanols; Permeability; Pharmaceutical Preparations; Skin Absorption; Water

2007
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds.
    Bioorganic & medicinal chemistry, 2007, Nov-15, Volume: 15, Issue:22

    Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption

2007
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
    Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship

2008
Convenient QSAR model for predicting the complexation of structurally diverse compounds with beta-cyclodextrins.
    Bioorganic & medicinal chemistry, 2009, Jan-15, Volume: 17, Issue:2

    Topics: beta-Cyclodextrins; Hydrophobic and Hydrophilic Interactions; Organic Chemicals; Quantitative Structure-Activity Relationship

2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:11

    Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
QSAR-based solubility model for drug-like compounds.
    Bioorganic & medicinal chemistry, 2010, Oct-01, Volume: 18, Issue:19

    Topics: Databases, Factual; Models, Molecular; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Solubility; Water

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Toxicological evaluation of acyl glucuronides of nonsteroidal anti-inflammatory drugs using human embryonic kidney 293 cells stably expressing human UDP-glucuronosyltransferase and human hepatocytes.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Camphanes; Comet Assay; DNA Damage; Glucuronides; Glucuronosyltransferase; HEK293 Cells; Hepatocytes; Humans; Kidney

2011
QSAR-based permeability model for drug-like compounds.
    Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8

    Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2011
Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1

    Topics: Cell Line, Tumor; Cryopreservation; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Predictive Value of Tests

2012
Self-organizing molecular field analysis of NSAIDs: assessment of pharmacokinetic and physicochemical properties using 3D-QSPkR approach.
    European journal of medicinal chemistry, 2012, Volume: 53

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemical Phenomena; Computational Biology; Least-Squares Analysis; Models, Molecular; Molecular Conformation; Quantitative Structure-Activity Relationship

2012
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
    Pharmaceutical research, 2014, Volume: 31, Issue:4

    Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation

2014
Characterization of two distinct modes of drug binding to human intestinal fatty acid binding protein.
    ACS chemical biology, 2014, Nov-21, Volume: 9, Issue:11

    Topics: Fatty Acid-Binding Proteins; Fluorescent Dyes; Humans; Nuclear Magnetic Resonance, Biomolecular; Protein Binding; Spectrometry, Fluorescence

2014
Inhibition of FAAH, TRPV1, and COX2 by NSAID-serotonin conjugates.
    Bioorganic & medicinal chemistry letters, 2014, Dec-15, Volume: 24, Issue:24

    Topics: Amidohydrolases; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Flurbiprofen; Humans; Serotonin; TRPV Cation Channels

2014
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
    PloS one, 2016, Volume: 11, Issue:10

    Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat

2016
Ophthalmic screening of patients receiving ketoprofen or flurbiprofen medication for inflammatory and degenerative joint diseases.
    Scandinavian journal of rheumatology. Supplement, 1976, Volume: 1976, Issue:0

    Topics: Adult; Aged; Analgesics; Arthritis; Benzophenones; Cornea; Eye; Female; Flurbiprofen; Follow-Up Studies; Humans; Joint Diseases; Ketoprofen; Lens, Crystalline; Male; Middle Aged; Propionates; Retina; Time Factors; Visual Acuity

1976
Development of extended-release solid dispersions of nonsteroidal antiinflammatory drugs with aqueous polymeric dispersions: optimization of drug release via a curve-fitting technique.
    Pharmaceutical research, 1992, Volume: 9, Issue:2

    Topics: Acrylic Resins; Anti-Inflammatory Agents, Non-Steroidal; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Delayed-Action Preparations; Drug Carriers; Flurbiprofen; Ketoprofen; Kinetics; Particle Size; Polymers; Suspensions

1992
Metabolic chiral inversion of 2-arylpropionates in rat H4IIE and human Hep G2 hepatoma cells. Relationship to in vivo metabolism.
    Biochemical pharmacology, 1992, Apr-01, Volume: 43, Issue:7

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biotransformation; Flurbiprofen; Humans; Ibuprofen; Ketoprofen; Rats; Species Specificity; Stereoisomerism; Tumor Cells, Cultured

1992
Inhibition of human periodontal prostaglandin E2 synthesis with selected agents.
    Agents and actions, 1990, Volume: 29, Issue:3-4

    Topics: Arachidonic Acid; Arachidonic Acids; Chromatography, High Pressure Liquid; Cyclooxygenase Inhibitors; Dinoprostone; Eicosapentaenoic Acid; Flurbiprofen; Humans; Ibuprofen; Ketoprofen; Meclofenamic Acid; Naproxen; Periodontitis; Periodontium; Vitamin E

1990
Chromatographic approaches to the quality control of chiral propionate anti-inflammatory drugs and herbicides.
    Journal of chromatography, 1989, May-19, Volume: 469

    Topics: 2-Methyl-4-chlorophenoxyacetic Acid; 2,4-Dichlorophenoxyacetic Acid; Anti-Inflammatory Agents, Non-Steroidal; Chemical Phenomena; Chemistry; Chromatography, Gas; Flurbiprofen; Herbicides; Ibuprofen; Ketoprofen; Quality Control; Stereoisomerism

1989
The properties of solid dispersions of indomethacin, ketoprofen and flurbiprofen in phosphatidylcholine.
    Chemical & pharmaceutical bulletin, 1988, Volume: 36, Issue:6

    Topics: Chemical Phenomena; Chemistry, Pharmaceutical; Chemistry, Physical; Flurbiprofen; Indomethacin; Ketoprofen; Phenylpropionates; Phosphatidylcholines; Powders; Propionates

1988
Stereospecific high-performance liquid chromatographic (HPLC) assay of flurbiprofen in biological specimens.
    Pharmaceutical research, 1988, Volume: 5, Issue:2

    Topics: Chromatography, High Pressure Liquid; Flurbiprofen; Humans; Ketoprofen; Propionates; Stereoisomerism

1988
Study of the interactions between sulfamethizole and three anti-inflammatory propionic acid derivatives at the renal level in rats.
    Chemical & pharmaceutical bulletin, 1985, Volume: 33, Issue:11

    Topics: Animals; Anti-Inflammatory Agents; Drug Interactions; Flurbiprofen; Ketoprofen; Male; Phenylbutyrates; Propionates; Rats; Rats, Inbred Strains; Sulfamethizole; Sulfathiazoles

1985
[Flurbiprofen and ketoprofen per os and rectum: efficacy and tolerability in spondyloarthrosis].
    La Clinica terapeutica, 1983, Dec-31, Volume: 107, Issue:6

    Topics: Administration, Oral; Adult; Aged; Drug Evaluation; Female; Flurbiprofen; Humans; Ketoprofen; Male; Middle Aged; Phenylpropionates; Propionates; Spondylitis; Suppositories

1983
Arachidonic acid metabolites and the gastro-intestinal toxicity of anti-inflammatory agents.
    Prostaglandins, 1981, Volume: 21 Suppl

    Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Aspirin; Cyclooxygenase Inhibitors; Digestive System; Flurbiprofen; Gastric Mucosa; Indomethacin; Intestinal Mucosa; Ketoprofen; Naproxen; Prostaglandins; Rats

1981
Novel nonsteroidal anti-inflammatory drug derivatives with markedly reduced ulcerogenic properties in the rat.
    Gastroenterology, 1994, Volume: 107, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Adhesion; Flurbiprofen; Ketoprofen; Leukocytes; Male; Nitrates; Nitrites; Nitrogen Oxides; Platelet Aggregation; Prostaglandins; Rats; Rats, Wistar; Stomach Ulcer; Structure-Activity Relationship

1994
Metabolic chiral inversion of 2-arylpropionates in different tumor cell lines.
    Agents and actions. Supplements, 1993, Volume: 44

    Topics: Animals; Carcinoma, Hepatocellular; Cell Count; Culture Media; Flurbiprofen; Humans; Ibuprofen; Ketoprofen; Liver Neoplasms; Liver Neoplasms, Experimental; Propionates; Rats; Species Specificity; Stereoisomerism; Tumor Cells, Cultured

1993
Stereoselectivity of biliary excretion of 2-arylpropionates in rats.
    Chirality, 1993, Volume: 5, Issue:6

    Topics: Animals; Bile; Flurbiprofen; Ibuprofen; Injections, Intravenous; Ketoprofen; Male; Rats; Rats, Sprague-Dawley; Stereoisomerism

1993
Inhibition of inducible nitric oxide synthase expression by novel nonsteroidal anti-inflammatory derivatives with gastrointestinal-sparing properties.
    British journal of pharmacology, 1996, Volume: 117, Issue:7

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blotting, Western; Cell Line; Enzyme Induction; Escherichia coli; Flurbiprofen; Ketoprofen; Lipopolysaccharides; Macrophages; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitrites

1996
Stereoselective inhibition of inducible cyclooxygenase by chiral nonsteroidal antiinflammatory drugs.
    Journal of clinical pharmacology, 1996, Volume: 36, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Female; Flurbiprofen; Guinea Pigs; Humans; Isoenzymes; Ketoprofen; Ketorolac; Male; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Sheep; Stereoisomerism; Tolmetin

1996
Effect of the enantiomers of flurbiprofen, ibuprofen, and ketoprofen on intestinal permeability.
    Journal of pharmaceutical sciences, 1996, Volume: 85, Issue:11

    Topics: Animals; Dose-Response Relationship, Drug; Flurbiprofen; Ibuprofen; Intestinal Absorption; Ketoprofen; Male; Rats; Rats, Sprague-Dawley; Stereoisomerism

1996
Inhibition of tolbutamide 4-methylhydroxylation by a series of non-steroidal anti-inflammatory drugs in V79-NH cells expressing human cytochrome P4502C10.
    Xenobiotica; the fate of foreign compounds in biological systems, 1996, Volume: 26, Issue:12

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aryl Hydrocarbon Hydroxylases; Cell Line; Cricetinae; Cricetulus; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Diclofenac; Drug Interactions; Enzyme Inhibitors; Flurbiprofen; Gene Expression; Humans; Hydroxylation; Ketoprofen; Lung; Methylation; Mixed Function Oxygenases; Phenylbutazone; Sulfaphenazole; Tolbutamide; Transfection

1996
Serum protein binding of nonsteroidal antiinflammatory drugs: a comparative study.
    Journal of pharmacokinetics and biopharmaceutics, 1997, Volume: 25, Issue:1

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Chromatography, High Pressure Liquid; Diclofenac; Female; Fenoprofen; Flurbiprofen; Humans; Ketoprofen; Male; Middle Aged; Naproxen; Protein Binding; Tolmetin

1997
Effect of chemical structure on the release of certain propionic acid derivatives from their dosage forms.
    Drug development and industrial pharmacy, 1998, Volume: 24, Issue:5

    Topics: Capsules; Chemical Phenomena; Chemistry, Physical; Dosage Forms; Drug Compounding; Drug Stability; Drug Storage; Flurbiprofen; Humans; Ibuprofen; Ketoprofen; Molecular Structure; Naproxen; Propionates; Suppositories

1998
Antinociceptive effects of S(+)-ketoprofen and other analgesic drugs in a rat model of pain induced by uric acid.
    Journal of clinical pharmacology, 1998, Volume: 38, Issue:S1

    Topics: Administration, Oral; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Biotransformation; Disease Models, Animal; Dose-Response Relationship, Drug; Flurbiprofen; Injections, Intraventricular; Ketoprofen; Ketorolac; Male; Morphine; Pain; Rats; Rats, Sprague-Dawley; Rats, Wistar; Stereoisomerism; Tolmetin; Tromethamine; Uric Acid

1998
R- and S-isomers of nonsteroidal anti-inflammatory drugs differentially regulate cytokine production.
    European cytokine network, 2000, Volume: 11, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cytokines; Dinoprostone; Female; Flurbiprofen; Ibuprofen; In Vitro Techniques; Interleukin-10; Interleukin-6; Ketoprofen; Lipopolysaccharides; Macrophages, Peritoneal; Mice; RNA, Messenger; Stereoisomerism; Tumor Necrosis Factor-alpha

2000
Chiral resolution of flurbiprofen and ketoprofen enantiomers by HPLC on a glycopeptide-type column chiral stationary phase.
    Biomedical chromatography : BMC, 2001, Volume: 15, Issue:3

    Topics: Buffers; Chromatography, High Pressure Liquid; Drug Stability; Flurbiprofen; Furans; Glycopeptides; Hydrogen-Ion Concentration; Indicators and Reagents; Ketoprofen; Nitrates; Sensitivity and Specificity; Stereoisomerism

2001
Estimation of acute flurbiprofen and ketoprofen toxicity in rat gastric mucosa at therapy-relevant doses.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2001, Volume: 50, Issue:12

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Female; Flurbiprofen; Gastric Mucosa; Injections, Subcutaneous; Intubation, Gastrointestinal; Isoenzymes; Ketoprofen; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Stereoisomerism; Stomach Ulcer; Sulfonamides

2001
Molecular modelling of the differential interaction between several non-steroidal anti-inflammatory drugs and human prostaglandin endoperoxide H synthase-2 (h-PGHS-2).
    Journal of molecular graphics & modelling, 2002, Volume: 20, Issue:4

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Computer Graphics; Computer Simulation; Crystallography, X-Ray; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Energy Transfer; Flurbiprofen; Humans; Indomethacin; Isoenzymes; Ketoprofen; Meclofenamic Acid; Mefenamic Acid; Membrane Proteins; Models, Molecular; Naproxen; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides

2002
Enhancement of selectivity and resolution in the enantioseparation of uncharged compounds using mixtures of oppositely charged cyclodextrins in capillary electrophoresis.
    Electrophoresis, 2003, Volume: 24, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cyclodextrins; Electrophoresis, Capillary; Fenoprofen; Flurbiprofen; Ibuprofen; Ketoprofen; Static Electricity; Stereoisomerism

2003
Modeling of adhesion in tablet compression--I. Atomic force microscopy and molecular simulation.
    Journal of pharmaceutical sciences, 2003, Volume: 92, Issue:4

    Topics: Adhesiveness; Chemistry, Pharmaceutical; Compressive Strength; Drug Compounding; Flurbiprofen; Ibuprofen; Iron; Ketoprofen; Microscopy, Atomic Force; Models, Molecular; Surface Properties; Tablets; X-Ray Diffraction

2003
Simultaneous chiral discrimination of multiple profens by cyclodextrin-modified capillary electrophoresis in normal and reversed polarity modes.
    Electrophoresis, 2003, Volume: 24, Issue:15

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cyclodextrins; Electrophoresis, Capillary; Flurbiprofen; Hexadimethrine Bromide; Ibuprofen; Ketoprofen; Phenylpropionates; Stereoisomerism

2003
Modeling of adhesion in tablet compression. II. Compaction studies using a compaction simulator and an instrumented tablet press.
    Journal of pharmaceutical sciences, 2004, Volume: 93, Issue:2

    Topics: Adhesiveness; Algorithms; Anti-Inflammatory Agents, Non-Steroidal; Drug Compounding; Flurbiprofen; Ibuprofen; Ketoprofen; Lubrication; Pressure; Surface Properties; Tablets

2004
Investigation of the release test method for the topical application of pharmaceutical preparations: release test of cataplasm including nonsteroidal anti-inflammatory drugs using artificial sweat.
    Chemical & pharmaceutical bulletin, 2004, Volume: 52, Issue:2

    Topics: Administration, Topical; Anti-Inflammatory Agents, Non-Steroidal; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Delayed-Action Preparations; Flurbiprofen; Humans; Ibuprofen; Ketoprofen; Kinetics; Solubility; Sweat; Tablets

2004
Nonsteroidal anti-inflammatory drug-induced liver injury: a case-control study in primary care.
    Fundamental & clinical pharmacology, 2004, Volume: 18, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Cholestasis; Diclofenac; Drug Therapy, Combination; Female; Flurbiprofen; Hepatocytes; Humans; Ibuprofen; Ketoprofen; Liver; Male; Meloxicam; Middle Aged; Niflumic Acid; Primary Health Care; Salicylates; Sex Distribution; Statistics, Nonparametric; Thiazines; Thiazoles; Time Factors

2004
Enantioseparation of flurbiprofen and ketoprofen in patches and in urine excretions by achiral gas chromatography.
    Archives of pharmacal research, 2004, Volume: 27, Issue:12

    Topics: Chromatography, Gas; Flurbiprofen; Humans; Ketoprofen; Male; Reproducibility of Results; Stereoisomerism

2004
Study on the mechanism of photosensitive dermatitis caused by ketoprofen in the guinea pig.
    Archives of toxicology, 2006, Volume: 80, Issue:7

    Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dermatitis, Phototoxic; Dose-Response Relationship, Drug; Female; Flurbiprofen; Guinea Pigs; Ketoprofen; Phenylpropionates; Skin; Stereoisomerism; Ultraviolet Rays

2006
"In vitro" differences among (R) and (S) enantiomers of profens in their activities related to articular pathophysiology.
    Inflammation, 2005, Volume: 29, Issue:4-6

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Cell Survival; Cells, Cultured; Chondrocytes; Dinoprostone; Femur Head; Flurbiprofen; Glycosaminoglycans; Humans; Interleukin-1beta; Ketoprofen; Matrix Metalloproteinase 3; Nitrites; Reactive Oxygen Species; Stereoisomerism

2005
Electrokinetic migration of acidic drugs across a supported liquid membrane.
    Journal of chromatography. A, 2007, Jun-08, Volume: 1152, Issue:1-2

    Topics: Acids; Chromatography, Micellar Electrokinetic Capillary; Electrophoresis, Capillary; Flurbiprofen; Gemfibrozil; Heptanol; Hydrogen-Ion Concentration; Ketoprofen; Membranes, Artificial; Naproxen; Pharmaceutical Preparations; Probenecid; Reproducibility of Results; Warfarin

2007
Cross-reaction allergic pancreatitis with ketoprofen and flurbiprofen.
    Pancreas, 2007, Volume: 35, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Budesonide; Cross Reactions; Female; Flurbiprofen; Humans; Hypersensitivity; Ketoprofen; Middle Aged; Pancreatitis; Scopolamine Derivatives; Tiotropium Bromide; Treatment Outcome

2007
Analysis of flurbiprofen, ketoprofen and etodolac enantiomers by pre-column derivatization RP-HPLC and application to drug-protein binding in human plasma.
    Journal of pharmaceutical and biomedical analysis, 2008, Apr-14, Volume: 46, Issue:5

    Topics: Acetonitriles; Anti-Inflammatory Agents, Non-Steroidal; Blood Proteins; Buffers; Chromatography, High Pressure Liquid; Ethylamines; Ethyldimethylaminopropyl Carbodiimide; Etodolac; Flurbiprofen; Humans; Hydrogen-Ion Concentration; Ketoprofen; Naphthalenes; Protein Binding; Reproducibility of Results; Solvents; Stereoisomerism; Sulfur Oxides; Triazoles

2008
Ionic liquid-based dynamic liquid-phase microextraction: application to the determination of anti-inflammatory drugs in urine samples.
    Journal of chromatography. A, 2008, Aug-15, Volume: 1202, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemical Fractionation; Flurbiprofen; Humans; Hydrogen-Ion Concentration; Indomethacin; Ionic Liquids; Ketoprofen; Molecular Structure; Naproxen; Phenylbutyrates; Reproducibility of Results; Tolmetin

2008
Enantiomeric separation of acidic compounds by nano-liquid chromatography with methylated-beta-cyclodextrin as a mobile phase additive.
    Journal of separation science, 2009, Volume: 32, Issue:10

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Benzoxazoles; beta-Cyclodextrins; Carbazoles; Chromatography, Liquid; Flurbiprofen; Hydrogen-Ion Concentration; Indoprofen; Ketoprofen; Methylation; Molecular Structure; Nanotechnology; Naproxen; Propionates; Stereoisomerism; Suprofen; Time Factors

2009
Differences in the interaction between aryl propionic acid derivatives and poly(vinylpyrrolidone) K30: A multi-methodological approach.
    Journal of pharmaceutical sciences, 2009, Volume: 98, Issue:11

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Calorimetry, Differential Scanning; Carbon Isotopes; Crystallization; Drug Stability; Flurbiprofen; Hot Temperature; Humidity; Hydrogen Bonding; Ibuprofen; Ketoprofen; Magnetic Resonance Spectroscopy; Molecular Structure; Molecular Weight; Naproxen; Phase Transition; Phenylbutyrates; Polymers; Povidone; Static Electricity; X-Ray Diffraction

2009
Structural evaluation of crystalline ternary γ-cyclodextrin complex.
    Journal of pharmaceutical sciences, 2011, Volume: 100, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Calorimetry, Differential Scanning; Chemical Precipitation; Excipients; Flurbiprofen; gamma-Cyclodextrins; Ketoprofen; Magnetic Resonance Spectroscopy; Molecular Conformation; Naproxen; Pharmaceutic Aids; Powder Diffraction; Salicylic Acid; Spectroscopy, Fourier Transform Infrared; Water

2011
Evaluation of percutaneous permeation of flurbiprofen and ketoprofen after application of transdermal patches using a lateral sectioning approach in hairless rats.
    Pharmaceutical development and technology, 2010, Volume: 15, Issue:6

    Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Delivery Systems; Flurbiprofen; Ketoprofen; Male; Permeability; Rats; Rats, Hairless; Skin Absorption; Tissue Distribution; Transdermal Patch

2010
Determination of non-steroidal anti-inflammatory drugs in urine by the combination of stir membrane liquid-liquid-liquid microextraction and liquid chromatography.
    Analytical and bioanalytical chemistry, 2012, Volume: 403, Issue:9

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Chromatography, Liquid; Flurbiprofen; Humans; Indomethacin; Ketoprofen; Limit of Detection; Liquid Phase Microextraction; Naproxen

2012
Sensing chiral drugs by using CdSe/ZnS nanoparticles capped with N-acetyl-L-cysteine methyl ester.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2013, Aug-12, Volume: 19, Issue:33

    Topics: Acetylcysteine; Cadmium Compounds; Circular Dichroism; Esters; Flurbiprofen; Ibuprofen; Ketoprofen; Naproxen; Pharmaceutical Preparations; Quantum Dots; Selenium Compounds; Spectrometry, Fluorescence; Stereoisomerism; Sulfides; Zinc Compounds

2013
Determination of thermodynamic values of acidic dissociation constants and complexation constants of profens and their utilization for optimization of separation conditions by Simul 5 Complex.
    Journal of chromatography. A, 2014, Oct-17, Volume: 1364

    Topics: Anti-Inflammatory Agents, Non-Steroidal; beta-Cyclodextrins; Computer Simulation; Electrophoresis, Capillary; Flurbiprofen; Hydrogen-Ion Concentration; Ibuprofen; Ketoprofen; Magnetic Resonance Spectroscopy; Naproxen; Osmolar Concentration; Software; Thermodynamics; Viscosity

2014
Parallel artificial liquid membrane extraction of acidic drugs from human plasma.
    Analytical and bioanalytical chemistry, 2015, Volume: 407, Issue:10

    Topics: Calibration; Chromatography, High Pressure Liquid; Diclofenac; Equipment Design; Flurbiprofen; Gemfibrozil; Humans; Hydrogen-Ion Concentration; Ibuprofen; Ketoprofen; Liquid-Liquid Extraction; Membranes, Artificial; Pharmaceutical Preparations; Polypropylenes; Polyvinyls

2015
Effect of guest drug character encapsulated in the cavity and intermolecular spaces of γ-cyclodextrins on the dissolution property of ternary γ-cyclodextrin complex.
    International journal of pharmaceutics, 2017, Oct-15, Volume: 531, Issue:2

    Topics: Chemistry, Pharmaceutical; Drug Carriers; Flurbiprofen; gamma-Cyclodextrins; Ketoprofen; Naproxen; Salicylamides; Solubility

2017
The nature of hydrogen-bonding interactions in nonsteroidal anti-inflammatory drugs revealed by polarized IR spectroscopy.
    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2018, Jan-05, Volume: 188

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Crystallography, X-Ray; Deuterium; Flurbiprofen; Hydrogen Bonding; Ketoprofen; Naproxen; Spectrophotometry, Infrared; Vibration

2018
Levetiracetam+nonsteroidal anti-inflammatory drug binary systems: A contribution to the development of new solid dosage forms.
    International journal of pharmaceutics, 2017, Nov-25, Volume: 533, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Drug Combinations; Drug Liberation; Flurbiprofen; Ibuprofen; Ketoprofen; Levetiracetam; Naproxen; Piracetam; Stereoisomerism

2017
Correlation between glucuronidation and covalent adducts formation with proteins of nonsteroidal anti-inflammatory drugs.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2018, Jan-15, Volume: 112

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzopyrans; Flurbiprofen; Glucuronides; Ibuprofen; Ketoprofen; Male; Microsomes, Liver; Naproxen; Propionates; Protein Binding; Rats, Wistar

2018
Dried blood spots and parallel artificial liquid membrane extraction-A simple combination of microsampling and microextraction.
    Analytica chimica acta, 2018, Jun-07, Volume: 1009

    Topics: Amitriptyline; Chromatography, High Pressure Liquid; Dried Blood Spot Testing; Fenoprofen; Flurbiprofen; Healthy Volunteers; Humans; Ibuprofen; Ketoprofen; Liquid-Liquid Extraction; Membranes, Artificial; Quetiapine Fumarate; Tandem Mass Spectrometry

2018
Analgesic effect of S (+)-flurbiprofen plaster in a rat model of knee arthritis: analysis of gait and synovial fluid prostaglandin E
    The Journal of pharmacy and pharmacology, 2018, Volume: 70, Issue:7

    Topics: Analgesics; Animals; Arthritis, Experimental; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Flurbiprofen; Gait; Ketoprofen; Male; Phenylpropionates; Rats; Synovial Fluid; Transdermal Patch

2018
Switchable-hydrophilicity solvent liquid-liquid microextraction of non-steroidal anti-inflammatory drugs from biological fluids prior to HPLC-DAD determination.
    Journal of pharmaceutical and biomedical analysis, 2019, Sep-10, Volume: 174

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Centrifugation; Chromatography, High Pressure Liquid; Etodolac; Flurbiprofen; Humans; Hydrophobic and Hydrophilic Interactions; Ibuprofen; Ketoprofen; Linear Models; Liquid Phase Microextraction; Milk, Human; Organic Chemicals; Reproducibility of Results; Saliva; Sodium Hydroxide; Solvents

2019
Facile synthesis of magnetic carbon nanotubes derived from ZIF-67 and application to magnetic solid-phase extraction of profens from human serum.
    Talanta, 2020, Jan-15, Volume: 207

    Topics: Adsorption; Cobalt; Flurbiprofen; Humans; Imidazoles; Ketoprofen; Magnets; Metal Nanoparticles; Nanotubes, Carbon; Organometallic Compounds; Solid Phase Extraction

2020
Hybrid monoliths with metal-organic frameworks in spin columns for extraction of non-steroidal drugs prior to their quantitation by reversed-phase HPLC.
    Mikrochimica acta, 2019, 11-11, Volume: 186, Issue:12

    Topics: Adsorption; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Flurbiprofen; Humans; Ibuprofen; Ketoprofen; Limit of Detection; Metal-Organic Frameworks; Methylmethacrylates; Solid Phase Microextraction

2019
UPLC-based assay to assess the hydrophobicity of Antibody-Drug Conjugate (ADC) payloads.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2020, Jun-01, Volume: 1146

    Topics: Biological Assay; Calicheamicins; Chromatography, High Pressure Liquid; Doxorubicin; Flurbiprofen; Hydrophobic and Hydrophilic Interactions; Ibuprofen; Immunoconjugates; Irinotecan; Ketoprofen; Maytansine; Molecular Conformation; Norfloxacin; Pentachlorophenol; Protein Multimerization; Structure-Activity Relationship; Tandem Mass Spectrometry; Tolnaftate

2020
Modeling of Adhesion in Tablet Compression at the Molecular Level Using Thermal Analysis and Molecular Simulations.
    Molecular pharmaceutics, 2022, 01-03, Volume: 19, Issue:1

    Topics: Adhesiveness; Calorimetry, Differential Scanning; Compressive Strength; Flurbiprofen; Ibuprofen; Ketoprofen; Models, Molecular; Tablets

2022
Disposable stochastic sensors for fast analysis of ibuprofen, ketoprofen, and flurbiprofen in their topical pharmaceutical formulations.
    Journal of pharmaceutical and biomedical analysis, 2022, Jun-05, Volume: 215

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Carbon; Copper; Drug Compounding; Flurbiprofen; Ibuprofen; Ketoprofen

2022
An Evolving Role of Aqueous Piperazine to Improve the Solubility of Non-Steroidal Anti-Inflammatory Drugs.
    Journal of pharmaceutical sciences, 2022, Volume: 111, Issue:10

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Calorimetry, Differential Scanning; Flurbiprofen; Ibuprofen; Indomethacin; Ketoprofen; Phenylbutazone; Piperazine; Powders; Salts; Solubility; Spectroscopy, Fourier Transform Infrared; Sulindac; Water; X-Ray Diffraction

2022