ketoprofen and caffeine

ketoprofen has been researched along with caffeine in 42 studies

Research

Studies (42)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	23 (54.76)	29.6817
2010's	17 (40.48)	24.3611
2020's	2 (4.76)	2.80

Authors

Authors	Studies
Andricopulo, AD; Moda, TL; Montanari, CA	1
Duffy, EM; Jorgensen, WL	1
Topliss, JG; Yoshida, F	1
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL	1
Carrupt, PA; Martel, S; Ottaviani, G	2
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J	1
Akamatsu, M; Fujikawa, M; Nakao, K; Shimizu, R	1
Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y	1
Lombardo, F; Obach, RS; Waters, NJ	1
He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Botta, M; Dreassi, E; Falchi, F; Maga, G; Santucci, A; Schenone, S; Zizzari, AT	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S	1
Conradi, R; Lee, PH; Shanmugasundaram, V	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Campillo, NE; Guerra, A; Páez, JA	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Avdeef, A; Tam, KY	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Akamatsu, M	1
Bellera, CL; Bruno-Blanch, LE; Castro, EA; Duchowicz, PR; Goodarzi, M; Ortiz, EV; Pesce, G; Talevi, A	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Caradonna, NP; Hallifax, D; Houston, JB; Turlizzi, E; Zanelli, U	1
Barber, S; Dew, TP; Farrell, TL; Poquet, L; Williamson, G	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Amann, R; Ates, M; Brune, K; Gühring, H; Peskar, BA; Sommerauer, M	1
Asakawa, N; Ishihama, Y; Murata, K; Yamamoto, E	1
Kutter, JP; Mogensen, KB; Petersen, NJ	1
Bock, U; Haltner, E; Krause, W; Otto, J	1
Eriksson, F; Gustafsson, O; Kutter, JP; Mogensen, KB; Nikolajsen, RP	1
Foster, GD; Thomas, PM	1
Balwinski, KM; Mitchell, SA	1
Michniak-Kohn, B; Zhang, J	1
Gersberg, RM; Hua, T; Tan, SK; Tuan, NA; Zhang, DQ; Zhu, J	1
Gersberg, RM; Hua, T; Jinadasa, KB; Tan, SK; Zhang, DQ; Zhu, J	1
Mahugo-Santana, C; Montesdeoca-Esponda, S; Santana-Rodríguez, JJ; Sosa-Ferrera, Z	1
Caldas, LL; Espíndola, ELG; Moreira, RA; Novelli, A	1
Masís-Mora, M; Méndez-Rivera, M; Montiel-Mora, JR; Ramírez-Morales, D; Rodríguez-Rodríguez, CE	1

Reviews

1 review(s) available for ketoprofen and caffeine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

1 trial(s) available for ketoprofen and caffeine

Article	Year
[Comparative in vitro and in vivo studies on the permeation and penetration of ketoprofen and ibuprofen in human skin]. Arzneimittel-Forschung, 2004, Volume: 54, Issue:9 Topics: Administration, Topical; Adult; Algorithms; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Diffusion Chambers, Culture; Female; Gels; Humans; Ibuprofen; In Vitro Techniques; Ketoprofen; Permeability; Skin Absorption	2004

Other Studies

40 other study(ies) available for ketoprofen and caffeine

Article	Year
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Prediction of drug solubility from Monte Carlo simulations. Bioorganic & medicinal chemistry letters, 2000, Jun-05, Volume: 10, Issue:11 Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility	2000
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Cheminformatic models to predict binding affinities to human serum albumin. Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25 Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids	2001
Parallel artificial membrane permeability assay: a new membrane for the fast prediction of passive human skin permeability. Journal of medicinal chemistry, 2006, Jun-29, Volume: 49, Issue:13 Topics: 1-Octanol; Diffusion; Dimethylpolysiloxanes; Humans; In Vitro Techniques; Membranes, Artificial; Myristates; Permeability; Skin; Skin Absorption; Water	2006
In silico and in vitro filters for the fast estimation of skin permeation and distribution of new chemical entities. Journal of medicinal chemistry, 2007, Feb-22, Volume: 50, Issue:4 Topics: Humans; Membranes, Artificial; Models, Biological; Models, Molecular; Octanols; Permeability; Pharmaceutical Preparations; Skin Absorption; Water	2007
Chemical genetics reveals a complex functional ground state of neural stem cells. Nature chemical biology, 2007, Volume: 3, Issue:5 Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells	2007
QSAR study on permeability of hydrophobic compounds with artificial membranes. Bioorganic & medicinal chemistry, 2007, Jun-01, Volume: 15, Issue:11 Topics: Biological Transport; Caco-2 Cells; Drug Evaluation, Preclinical; Humans; Hydrophobic and Hydrophilic Interactions; Membranes, Artificial; Permeability; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship	2007
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds. Bioorganic & medicinal chemistry, 2007, Nov-15, Volume: 15, Issue:22 Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
First-principle, structure-based prediction of hepatic metabolic clearance values in human. European journal of medicinal chemistry, 2009, Volume: 44, Issue:4 Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software	2009
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Determination of permeability and lipophilicity of pyrazolo-pyrimidine tyrosine kinase inhibitors and correlation with biological data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:9 Topics: Humans; Lipids; Membranes, Artificial; Permeability; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-abl; Pyrazoles; Pyrimidines	2009
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19 Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship	2009
Development of an in silico model for human skin permeation based on a Franz cell skin permeability assay. Bioorganic & medicinal chemistry letters, 2010, Jan-01, Volume: 20, Issue:1 Topics: 1-Methyl-3-isobutylxanthine; Cell Line; Cell Membrane Permeability; Humans; Models, Biological; Quantitative Structure-Activity Relationship; Skin Absorption	2010
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability? Journal of medicinal chemistry, 2010, May-13, Volume: 53, Issue:9 Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Importance of physicochemical properties for the design of new pesticides. Journal of agricultural and food chemistry, 2011, Apr-13, Volume: 59, Issue:7 Topics: Anabasine; Animals; Biological Availability; Cell Membrane Permeability; Chemical Phenomena; Drug Design; Humans; Imidazoles; Insecticides; Neonicotinoids; Nitro Compounds; Pesticides; Quantitative Structure-Activity Relationship; Receptors, Nicotinic	2011
Prediction of drug intestinal absorption by new linear and non-linear QSPR. European journal of medicinal chemistry, 2011, Volume: 46, Issue:1 Topics: Humans; Intestinal Absorption; Linear Models; Molecular Conformation; Nonlinear Dynamics; Permeability; Pharmaceutical Preparations; Probability; Quantitative Structure-Activity Relationship; Thermodynamics	2011
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1 Topics: Cell Line, Tumor; Cryopreservation; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Predictive Value of Tests	2012
Predicting phenolic acid absorption in Caco-2 cells: a theoretical permeability model and mechanistic study. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:2 Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Cinnamates; Enterocytes; Humans; Hydrophobic and Hydrophilic Interactions; Intestinal Absorption; Kinetics; Models, Biological; Molecular Conformation; Osmolar Concentration; Phenols	2012
Ketoprofen-induced cyclooxygenase inhibition in renal medulla and platelets of rats treated with caffeine. Pharmacology, 2001, Volume: 63, Issue:4 Topics: Animals; Blood Platelets; Caffeine; Cyclooxygenase Inhibitors; Dinoprostone; Drug Interactions; Gene Expression; Ketoprofen; Kidney Medulla; Male; Phosphodiesterase Inhibitors; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger	2001
Methylcellulose-immobilized reversed-phase precolumn for direct analysis of drugs in plasma by HPLC. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 2001, Volume: 17, Issue:10 Topics: Animals; Atenolol; Caffeine; Chromatography, Gel; Chromatography, High Pressure Liquid; Humans; Ketoprofen; Male; Methylcellulose; Pharmaceutical Preparations; Propranolol; Proteins; Rats; Silicon Dioxide; Time Factors	2001
Performance of an in-plane detection cell with integrated waveguides for UV/Vis absorbance measurements on microfluidic separation devices. Electrophoresis, 2002, Volume: 23, Issue:20 Topics: Absorption; Acetaminophen; Ascorbic Acid; Caffeine; Chemical Fractionation; Electrophoresis, Capillary; Ketoprofen; Miniaturization; Spectrophotometry, Ultraviolet	2002
Pure-silica optical waveguides, fiber couplers, and high-aspect ratio submicrometer channels for electrokinetic separation devices. Electrophoresis, 2004, Volume: 25, Issue:21-22 Topics: Acetaminophen; Caffeine; Electrophoresis, Microchip; Equipment Design; Fiber Optic Technology; Ketoprofen; Microfluidic Analytical Techniques; Silicon Dioxide; Ultraviolet Rays	2004
Tracking acidic pharmaceuticals, caffeine, and triclosan through the wastewater treatment process. Environmental toxicology and chemistry, 2005, Volume: 24, Issue:1 Topics: Caffeine; Diclofenac; Ibuprofen; Ketoprofen; Meclofenamic Acid; Models, Chemical; Naproxen; Pharmaceutical Preparations; Triclosan; Waste Disposal, Fluid; Water Pollutants, Chemical	2005
Investigation of hypromellose particle size effects on drug release from sustained release hydrophilic matrix tablets. Drug development and industrial pharmacy, 2007, Volume: 33, Issue:9 Topics: Acetaminophen; Caffeine; Chemistry, Pharmaceutical; Delayed-Action Preparations; Drug Carriers; Excipients; Hydrochlorothiazide; Hypromellose Derivatives; Ketoprofen; Methylcellulose; Metoprolol; Molecular Weight; Particle Size; Solubility; Tablets; Theophylline; Viscosity	2007
Investigation of microemulsion microstructures and their relationship to transdermal permeation of model drugs: ketoprofen, lidocaine, and caffeine. International journal of pharmaceutics, 2011, Dec-12, Volume: 421, Issue:1 Topics: Administration, Cutaneous; Animals; Azepines; Caffeine; Calorimetry, Differential Scanning; Electric Conductivity; Emulsions; Glycerides; Glycerol; Hydrophobic and Hydrophilic Interactions; In Vitro Techniques; Ketoprofen; Lidocaine; Myristates; Organic Chemicals; Permeability; Skin; Sulfur Compounds; Surface-Active Agents; Swine; Water	2011
Pharmaceutical removal in tropical subsurface flow constructed wetlands at varying hydraulic loading rates. Chemosphere, 2012, Volume: 87, Issue:3 Topics: Caffeine; Carbamazepine; Clofibric Acid; Diclofenac; Ecosystem; Environmental Restoration and Remediation; Ketoprofen; Models, Chemical; Pharmaceutical Preparations; Rhizosphere; Tropical Climate; Waste Disposal, Fluid; Water Movements; Water Pollutants, Chemical; Wetlands	2012
Batch versus continuous feeding strategies for pharmaceutical removal by subsurface flow constructed wetland. Environmental pollution (Barking, Essex : 1987), 2012, Volume: 167 Topics: Biodegradation, Environmental; Caffeine; Carbamazepine; Clofibric Acid; Diclofenac; Ibuprofen; Ketoprofen; Kinetics; Pharmaceutical Preparations; Waste Disposal, Fluid; Water Movements; Water Pollutants, Chemical; Wetlands	2012
A dispersive liquid-liquid micellar microextraction for the determination of pharmaceutical compounds in wastewaters using ultra-high-performace liquid chromatography with DAD detection. Biomedical chromatography : BMC, 2015, Volume: 29, Issue:3 Topics: Caffeine; Carbamazepine; Chloroform; Chromatography, High Pressure Liquid; Ketoprofen; Liquid Phase Microextraction; Micelles; Naproxen; Ornidazole; Osmolar Concentration; Pharmaceutical Preparations; Polidocanol; Polyethylene Glycols; Solvents; Spain; Temperature; Wastewater; Water Pollutants, Chemical	2015
Environmental Risk Assessment of Drugs in Tropical Freshwaters Using Ceriodaphnia silvestrii as Test Organism. Bulletin of environmental contamination and toxicology, 2023, Jun-07, Volume: 110, Issue:6 Topics: Acetaminophen; Animals; Caffeine; Cladocera; Diclofenac; Fresh Water; Ketoprofen; Risk Assessment; Salicylic Acid; Water Pollutants, Chemical	2023
On-farm Occurrence of Pharmaceuticals and Their Environmental Hazard: Case Study of a Tropical Dairy farm. Bulletin of environmental contamination and toxicology, 2023, Sep-26, Volume: 111, Issue:4 Topics: Acetaminophen; Animals; Caffeine; Carbamazepine; Environmental Monitoring; Farms; Ibuprofen; Ketoprofen; Pharmaceutical Preparations; Risperidone; Wastewater; Water; Water Pollutants, Chemical	2023