Compounds > ketononestrol aziridine
Page last updated: 2024-09-03

ketononestrol aziridine and tamoxifen

ketononestrol aziridine has been researched along with tamoxifen in 3 studies

Compound Research Comparison

Studies
(ketononestrol aziridine)		Trials
(ketononestrol aziridine)		Recent Studies (post-2010)
(ketononestrol aziridine)		Studies
(tamoxifen)		Trials
(tamoxifen)		Recent Studies (post-2010) (tamoxifen)
50020,6302,2276,256

Protein Interaction Comparison

ProteinTaxonomyketononestrol aziridine (IC50)tamoxifen (IC50)
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.46
Serine/threonine-protein kinase D3Homo sapiens (human)1
Bile salt export pumpHomo sapiens (human)10
Epidermal growth factor receptorHomo sapiens (human)3.553
Estrogen receptorHomo sapiens (human)0.9266
Receptor tyrosine-protein kinase erbB-2Homo sapiens (human)2.949
Protein kinase C gamma typeHomo sapiens (human)1
Protein kinase C beta typeHomo sapiens (human)1
Tyrosine-protein kinase LckHomo sapiens (human)8.033
Tyrosine-protein kinase FynHomo sapiens (human)1.195
Progesterone receptorHomo sapiens (human)0.1288
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)1.472
Muscarinic acetylcholine receptor M2Homo sapiens (human)7.793
Muscarinic acetylcholine receptor M4Homo sapiens (human)4.817
ATP-dependent translocase ABCB1Homo sapiens (human)6.4
Muscarinic acetylcholine receptor M5Homo sapiens (human)2.585
Alpha-2A adrenergic receptorHomo sapiens (human)1.935
Adenosine receptor A3Homo sapiens (human)3.701
Muscarinic acetylcholine receptor M1Homo sapiens (human)2.829
Steroid hormone receptor ERR1Homo sapiens (human)0.2
Angiotensin-converting enzymeOryctolagus cuniculus (rabbit)0.967
Beta-3 adrenergic receptorHomo sapiens (human)7.703
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)3.701
Protein kinase C alpha typeHomo sapiens (human)1
Alpha-2B adrenergic receptorHomo sapiens (human)3.518
Muscarinic acetylcholine receptor M3Homo sapiens (human)2.974
Substance-K receptorHomo sapiens (human)3.67
D(1A) dopamine receptorHomo sapiens (human)8.502
Prostaglandin G/H synthase 1Homo sapiens (human)4.391
Sodium-dependent noradrenaline transporter Homo sapiens (human)1.472
Thromboxane-A synthase Homo sapiens (human)0.916
Protein kinase C eta typeHomo sapiens (human)1
Histamine H2 receptorHomo sapiens (human)9.396
Alpha-1D adrenergic receptorHomo sapiens (human)4.982
5-hydroxytryptamine receptor 2AHomo sapiens (human)4.801
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.46
Adenosine receptor A2aHomo sapiens (human)7.099
Sodium-dependent serotonin transporterHomo sapiens (human)2.334
D(3) dopamine receptorHomo sapiens (human)1.072
5-hydroxytryptamine receptor 2BHomo sapiens (human)2.084
Protein kinase C iota typeHomo sapiens (human)1
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)3.701
5-hydroxytryptamine receptor 6Homo sapiens (human)2.679
Estrogen-related receptor gammaHomo sapiens (human)0.0622
Sodium-dependent dopamine transporter Homo sapiens (human)1.841
Protein kinase C epsilon typeHomo sapiens (human)1
Protein kinase C theta typeHomo sapiens (human)1
Protein kinase C zeta typeHomo sapiens (human)1
Protein kinase C delta typeHomo sapiens (human)1
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)1.2759
Platelet-activating factor acetylhydrolaseHomo sapiens (human)0.904
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomeraseHomo sapiens (human)0.012
Serine/threonine-protein kinase D1Homo sapiens (human)1
Nuclear receptor subfamily 3 group C member 3 Bos taurus (cattle)0.967
Estrogen receptor betaHomo sapiens (human)0.7809
Sigma non-opioid intracellular receptor 1Homo sapiens (human)0.021
7-dehydrocholesterol reductaseHomo sapiens (human)0.012

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19902 (66.67)18.7374
1990's1 (33.33)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Heierson, A; Katzenellenbogen, BS; McDonnell, DP; Nilsson, GM; Wooge, CH1
Greene, GL; Harlow, KW; Katzenellenbogen, BS; Katzenellenbogen, JA; Smith, DN1
Elliston, JF; Katzenellenbogen, BS1

Other Studies

3 other study(ies) available for ketononestrol aziridine and tamoxifen

ArticleYear
Structural requirements for high affinity ligand binding by estrogen receptors: a comparative analysis of truncated and full length estrogen receptors expressed in bacteria, yeast, and mammalian cells.
    Molecular endocrinology (Baltimore, Md.), 1992, Volume: 6, Issue:6

    Topics: Aziridines; Binding Sites; Breast Neoplasms; Escherichia coli; Estradiol; Humans; Ketones; Kinetics; Ligands; Neoplasm Proteins; Neoplasms, Hormone-Dependent; Peptide Fragments; Protein Binding; Protein Conformation; Receptors, Estrogen; Recombinant Fusion Proteins; Saccharomyces cerevisiae; Tamoxifen

1992
Identification of cysteine 530 as the covalent attachment site of an affinity-labeling estrogen (ketononestrol aziridine) and antiestrogen (tamoxifen aziridine) in the human estrogen receptor.
    The Journal of biological chemistry, 1989, Oct-15, Volume: 264, Issue:29

    Topics: Affinity Labels; Alkylation; Aziridines; Binding Sites; Chromatography, High Pressure Liquid; Cyanogen Bromide; Cysteine; Humans; Ketones; Peptide Fragments; Receptors, Estrogen; Serine Endopeptidases; Tamoxifen; Trypsin; Tumor Cells, Cultured

1989
Comparative analysis of estrogen receptors covalently labeled with an estrogen and an antiestrogen in several estrogen target cells as studied by limited proteolysis.
    Journal of steroid biochemistry, 1988, Volume: 29, Issue:6

    Topics: Affinity Labels; Animals; Aziridines; Azirines; Breast Neoplasms; Cell Line; Cell Nucleus; Female; Humans; Ketones; Peptide Fragments; Peptide Hydrolases; Pituitary Neoplasms; Rats; Rats, Inbred Strains; Receptors, Estrogen; Tamoxifen; Uterus

1988