ketoconazole and warfarin

ketoconazole has been researched along with warfarin in 42 studies

Research

Studies (42)

Timeframe	Studies, this research(%)	All Research%
pre-1990	3 (7.14)	18.7374
1990's	4 (9.52)	18.2507
2000's	14 (33.33)	29.6817
2010's	18 (42.86)	24.3611
2020's	3 (7.14)	2.80

Authors

Authors	Studies
Byun, JS; Kim, HJ; Lee, JY; Lee, KT; Leem, DG; Nam, JH; Park, B; Shin, DH; Shin, JS; Sohn, JM	1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y	1
Bloomer, WD; Papadopoulou, MV; Rosenzweig, HS	1
Chen, CH; De Clercq, E; Feng, D; Ginex, T; Kang, D; Lee, KH; Liu, X; Luque, FJ; Murugan, NA; Pannecouque, C; Steitz, TA; Wang, Z; Wei, F; Wu, G; Yang, Y; Zhan, P; Zhang, H; Zhang, J; Zhao, T	1
Adebesin, AM; Falck, JR; Fischer, R; Konkel, A; Lossie, J; Paudyal, MP; Puli, N; Schunck, WH; Vijaykumar, J; Wesser, T; Westphal, C; Zhu, C	1
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Gibaldi, M	1
Richardson, C; Soo, SC; Summerton, C; Yeh, J	1
Back, DJ; Stevenson, P; Tjia, JF	1
Klimek, JJ; Nightingale, CH; Owens, NJ; Quercia, RA; Quintiliani, R	1
Smith, AG	1
Kharasch, ED; Spracklin, DK; Thummel, KE	1
Jones, BC; Smith, DA; Tyman, CA	1
King, BM; Wong, YN; Zhang, ZY	1
Beckurts, KT; Brachtendorf, L; Fuhr, U; Hölscher, AH; Jetter, A	1
Fouda, HG; Khojasteh-Bakht, SC; Prakash, C; Rossulek, MI	1
Gottesdiener, KM; Kari, PP; Marbury, T; Miller, JL; Mistry, GC; Rodrigues, AD; Simpson, RC; Wagner, JA; Winchell, GA	1
Fuhr, U; Kober, S; Mutschler, E; Spahn-Langguth, H; Zaigler, M	1
de Graaf, IA; de Jager, MH; Groothuis, GM; Meijer, DK; van de Kerkhof, EG	1
Booth-Genthe, C; Carr, B; Fang, Y; Lu, P; Norcross, R; Rodrigues, AD; Rushmore, T; Shou, M	1
Hansen, TS; Nilsen, OG	1
Cheng, Q; Guengerich, FP; Sohl, CD	1
Cui, SL; Deng, JT; Kong, WL; Li, H; Tian, XT; Wen, YY; Xie, L; Zhuang, XM	1
Cheng, Q; Guengerich, FP	1
Aktan, G; Arkenau, HT; Blackman, SC; Botbyl, J; Carson, SW; Gordon, MS; Grossmann, KF; Infante, JR; Kendra, K; LoRusso, PM; Middleton, MR; Ouellet, D; Pant, S; Patel, M; Richards-Peterson, LE; Sharma, S; Suttle, AB	1
Buchmann, S; de Kanter, R; Delahaye, S; Gnerre, C; Kohl, C; Segrestaa, J; Sidharta, PN; Treiber, A	1
den Adel, M; Garcia-Hernandez, A; Groenendaal-van de Meent, D; Katashima, M; Kato, K; Kusawake, T; Ohtsu, Y; Takada, A	1
Ahemad, N; Dong, AN; Ong, CE; Palanisamy, UD; Pan, Y; Yiap, BC	1
Goto, T; Tohkin, M; Yamazoe, Y	1
Chen, JM; Fang, JS; Huang, MJ; Li, WR; Liang, Y; Lin, MJ; Liu, JM; Ma, CR; Wang, Q; Wu, FC; Yu, WQ; Zuo, X	1

Reviews

2 review(s) available for ketoconazole and warfarin

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Drug interactions: Part I. The Annals of pharmacotherapy, 1992, Volume: 26, Issue:5 Topics: Antidepressive Agents, Tricyclic; Caffeine; Cimetidine; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Induction; Fluconazole; Fluoxetine; Hexobarbital; Humans; Ketoconazole; Nimodipine; Oxidoreductases; Pharmaceutical Preparations; Rifampin; Stereoisomerism; Warfarin; Zidovudine	1992

Article

Year

DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.

Drug discovery today, 2016, Volume: 21, Issue:4

Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Drug interactions: Part I.

The Annals of pharmacotherapy, 1992, Volume: 26, Issue:5

Topics: Antidepressive Agents, Tricyclic; Caffeine; Cimetidine; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Induction; Fluconazole; Fluoxetine; Hexobarbital; Humans; Ketoconazole; Nimodipine; Oxidoreductases; Pharmaceutical Preparations; Rifampin; Stereoisomerism; Warfarin; Zidovudine

1992

Trials

3 trial(s) available for ketoconazole and warfarin

Article	Year
Treatment and prevention of oropharyngeal candidiasis. The American journal of medicine, 1984, Oct-30, Volume: 77, Issue:4D Topics: Adolescent; Adult; Aged; Aspergillosis; Candidiasis; Child; Child, Preschool; Clinical Trials as Topic; Clotrimazole; Drug Synergism; Half-Life; Humans; Infant; Ketoconazole; Middle Aged; Neoplasms; Pharyngeal Diseases; Placebos; Suppositories; Tablets; Warfarin	1984
The effect of ketoconazole on the pharmacokinetics of a selective alpha 1A-adrenoceptor antagonist. Journal of clinical pharmacology, 2005, Volume: 45, Issue:6 Topics: Administration, Oral; Adrenergic alpha-1 Receptor Antagonists; Adult; Area Under Curve; Carbon Radioisotopes; Coumarins; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Fomepizole; Half-Life; Humans; Ketoconazole; Male; Microsomes, Liver; Pyrazoles; Pyrimidinones; Quinidine; Receptors, Adrenergic, alpha-1; Sulfaphenazole; Theophylline	2005
Assessment of the drug interaction potential and single- and repeat-dose pharmacokinetics of the BRAF inhibitor dabrafenib. Journal of clinical pharmacology, 2015, Volume: 55, Issue:4 Topics: Anticoagulants; Cytochrome P-450 CYP2C8 Inhibitors; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Female; Gemfibrozil; Humans; Imidazoles; Ketoconazole; Male; Middle Aged; Oximes; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Warfarin	2015

Other Studies

37 other study(ies) available for ketoconazole and warfarin

Article	Year
In vitro synergistic anticancer activity of the combination of T-type calcium channel blocker and chemotherapeutic agent in A549 cells. Bioorganic & medicinal chemistry letters, 2016, Feb-01, Volume: 26, Issue:3 Topics: Animals; Antineoplastic Agents; Apoptosis; Calcium Channel Blockers; Calcium Channels, T-Type; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cyclins; Dogs; Down-Regulation; G1 Phase Cell Cycle Checkpoints; Half-Life; Humans; Mice; Microsomes, Liver; Quinazolines; Rats; Up-Regulation	2016
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16 Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone	2016
The antitubercular activity of various nitro(triazole/imidazole)-based compounds. Bioorganic & medicinal chemistry, 2017, 11-01, Volume: 25, Issue:21 Topics: Animals; Antitubercular Agents; Cell Line; Chlorocebus aethiops; Dose-Response Relationship, Drug; Humans; Imidazoles; Macrophages; Mice; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Nitro Compounds; Structure-Activity Relationship; Triazoles	2017
Identification of Dihydrofuro[3,4- d]pyrimidine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors with Promising Antiviral Activities and Desirable Physicochemical Properties. Journal of medicinal chemistry, 2019, 02-14, Volume: 62, Issue:3 Topics: Animals; Anti-HIV Agents; Binding Sites; Cell Line, Tumor; Furans; HIV Reverse Transcriptase; HIV-1; Humans; Male; Microbial Sensitivity Tests; Molecular Dynamics Simulation; Molecular Structure; Pyrimidines; Rats, Wistar; Reverse Transcriptase Inhibitors; Structure-Activity Relationship	2019
Development of Robust 17( Journal of medicinal chemistry, 2019, 11-27, Volume: 62, Issue:22 Topics: Administration, Oral; Animals; Anti-Arrhythmia Agents; Arachidonic Acids; Dose-Response Relationship, Drug; Drug Stability; Epoxide Hydrolases; Esterification; Hepatocytes; Humans; Male; Mice; Microsomes, Liver; Myocardial Infarction; Myocytes, Cardiac; Rats, Sprague-Dawley; Rats, Wistar	2019
Cheminformatic models to predict binding affinities to human serum albumin. Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25 Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids	2001
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Potentiation of action of warfarin by itraconazole. BMJ (Clinical research ed.), 1990, Sep-29, Volume: 301, Issue:6753 Topics: Antifungal Agents; Drug Synergism; Female; Hemorrhage; Humans; Itraconazole; Ketoconazole; Middle Aged; Warfarin	1990
Comparative effects of two antimycotic agents, ketoconazole and terbinafine on the metabolism of tolbutamide, ethinyloestradiol, cyclosporin and ethoxycoumarin by human liver microsomes in vitro. British journal of clinical pharmacology, 1989, Volume: 28, Issue:2 Topics: Antifungal Agents; Coumarins; Cyclosporins; Cytochrome P-450 Enzyme System; Ethinyl Estradiol; Female; Humans; In Vitro Techniques; Ketoconazole; Male; Microsomes, Liver; Naphthalenes; Terbinafine; Tolbutamide	1989
Potentiation of oral anticoagulants by ketoconazole. British medical journal (Clinical research ed.), 1984, Jan-21, Volume: 288, Issue:6412 Topics: Aged; Candidiasis, Vulvovaginal; Contusions; Drug Synergism; Female; Humans; Ketoconazole; Pulmonary Embolism; Warfarin	1984
Human reductive halothane metabolism in vitro is catalyzed by cytochrome P450 2A6 and 3A4. Drug metabolism and disposition: the biological fate of chemicals, 1996, Volume: 24, Issue:9 Topics: Anesthetics, Inhalation; Aryl Hydrocarbon Hydroxylases; Carbon Monoxide; Chlorofluorocarbons; Coumarins; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Halothane; Humans; In Vitro Techniques; Isoenzymes; Ketoconazole; Kinetics; Microsomes, Liver; Mixed Function Oxygenases; Recombinant Proteins	1996
Identification of the cytochrome P450 isoforms involved in the O-demethylation of 4-nitroanisole in human liver microsomes. Xenobiotica; the fate of foreign compounds in biological systems, 1997, Volume: 27, Issue:10 Topics: Adult; Aged; Anisoles; Anti-Infective Agents; Anticoagulants; Antifungal Agents; Antimalarials; Binding, Competitive; Coumarins; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Female; Humans; Isoenzymes; Ketoconazole; Kinetics; Male; Methylation; Microsomes, Liver; Middle Aged; Quinidine; Substrate Specificity; Sulfaphenazole; Theophylline	1997
Quantitative liquid chromatography/mass spectrometry/mass spectrometry warfarin assay for in vitro cytochrome P450 studies. Analytical biochemistry, 2001, Nov-01, Volume: 298, Issue:1 Topics: Calibration; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Hepatocytes; Humans; Ketoconazole; Mass Spectrometry; Microsomes, Liver; Polychlorinated Dibenzodioxins; Stereoisomerism; Warfarin	2001
Cytochrome P450 enzymes contributing to demethylation of maprotiline in man. Pharmacology & toxicology, 2002, Volume: 90, Issue:3 Topics: Cells, Cultured; Chlorzoxazone; Coumarins; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzymes; Humans; Ketoconazole; Kinetics; Maprotiline; Mephenytoin; Microsomes, Liver; Models, Biological; Quinidine; Sulfaphenazole; Theophylline	2002
Identification of the human cytochrome P450s responsible for the in vitro metabolism of a leukotriene B4 receptor antagonist, CP-195,543. Xenobiotica; the fate of foreign compounds in biological systems, 2003, Volume: 33, Issue:12 Topics: Adolescent; Adult; Aged; Chromans; Coumarins; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Female; Humans; Ketoconazole; Kinetics; Male; Mephenytoin; Microsomes, Liver; Middle Aged; NADP; Oxidation-Reduction; Quinidine; Receptors, Leukotriene B4; Recombinant Proteins; Sulfaphenazole; Theophylline	2003
Rate-limiting biotransformation of triamterene is mediated by CYP1A2. International journal of clinical pharmacology and therapeutics, 2005, Volume: 43, Issue:7 Topics: Caffeine; Chromatography, High Pressure Liquid; Coumarins; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Erythromycin; Humans; Hydroxylation; Ketoconazole; Kinetics; Microsomes, Liver; Omeprazole; Quinidine; Substrate Specificity; Sulfuric Acid Esters; Theophylline; Triamterene	2005
Characterization of rat small intestinal and colon precision-cut slices as an in vitro system for drug metabolism and induction studies. Drug metabolism and disposition: the biological fate of chemicals, 2005, Volume: 33, Issue:11 Topics: Animals; beta-Naphthoflavone; Colon; Coumarins; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Glucuronides; Intestine, Small; Ketoconazole; Male; Models, Animal; Rats; Rats, Wistar; Testosterone; Time Factors; Tissue Culture Techniques; Umbelliferones	2005
Characterization of the rhesus monkey CYP3A64 enzyme: species comparisons of CYP3A substrate specificity and kinetics using baculovirus-expressed recombinant enzymes. Drug metabolism and disposition: the biological fate of chemicals, 2006, Volume: 34, Issue:10 Topics: Amino Acid Sequence; Animals; Baculoviridae; Base Sequence; Blotting, Western; Cell Line; Cloning, Molecular; Coumarins; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DNA, Complementary; Humans; Ketoconazole; Kinetics; Liver; Macaca mulatta; Microsomes, Liver; Midazolam; Molecular Sequence Data; Nifedipine; Recombinant Proteins; Sequence Analysis, DNA; Spodoptera; Substrate Specificity; Testosterone	2006
In vitro CYP3A4 metabolism: inhibition by Echinacea purpurea and choice of substrate for the evaluation of herbal inhibition. Basic & clinical pharmacology & toxicology, 2008, Volume: 103, Issue:5 Topics: Binding Sites; Coumarins; Cytochrome P-450 CYP3A; Echinacea; Enzyme Inhibitors; Herb-Drug Interactions; Humans; Hypericum; Inhibitory Concentration 50; Ketoconazole; Plant Extracts; Quinolines; Testosterone	2008
High-throughput fluorescence assay of cytochrome P450 3A4. Nature protocols, 2009, Volume: 4, Issue:9 Topics: Coumarins; Cytochrome P-450 CYP3A; Humans; Inhibitory Concentration 50; Ketoconazole; Oxidation-Reduction; Software; Spectrometry, Fluorescence	2009
[Metabolism of 3-cyanomethyl-4-methyl-DCK, a new anti-HIV candidate, in human intestinal microsomes]. Yao xue xue bao = Acta pharmaceutica Sinica, 2010, Volume: 45, Issue:9 Topics: Anti-HIV Agents; Biological Availability; Bridged Bicyclo Compounds, Heterocyclic; Coumarins; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Humans; Intestinal Mucosa; Ketoconazole; Metabolic Clearance Rate; Microsomes; Ritonavir; Troleandomycin	2010
High-throughput fluorescence assay of cytochrome P450 3A4. Methods in molecular biology (Clifton, N.J.), 2013, Volume: 987 Topics: Coumarins; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Enzyme Assays; Humans; Inhibitory Concentration 50; Ketoconazole; Spectrometry, Fluorescence	2013
Physiologically-Based Pharmacokinetic Modeling of Macitentan: Prediction of Drug-Drug Interactions. Clinical pharmacokinetics, 2016, Volume: 55, Issue:3 Topics: Adult; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Humans; Ketoconazole; Male; Models, Biological; Pyrimidines; Rifampin; Sildenafil Citrate; Sulfonamides; Warfarin	2016
Pharmacokinetic Evaluation of the Interactions of Amenamevir (ASP2151) with Ketoconazole, Rifampicin, Midazolam, and Warfarin in Healthy Adults. Advances in therapy, 2017, Volume: 34, Issue:11 Topics: Adolescent; Adult; Area Under Curve; Cross-Over Studies; Cytochrome P-450 CYP3A; Double-Blind Method; Drug Interactions; Enzyme Induction; Humans; Ketoconazole; Male; Metabolic Clearance Rate; Midazolam; Middle Aged; Oxadiazoles; Rifampin; Warfarin; Young Adult	2017
The Molecular and Enzyme Kinetic Basis for Altered Activity of Three Cytochrome P450 2C19 Variants Found in the Chinese Population. Current molecular pharmacology, 2020, Volume: 13, Issue:3 Topics: Alleles; Amino Acid Sequence; Asian People; Catalytic Domain; Coumarins; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C19 Inhibitors; Fluoxetine; Humans; Ketoconazole; Kinetics; Loratadine; Models, Molecular; Molecular Docking Simulation; Mutagenesis, Site-Directed; Nitriles; Omeprazole; Polymorphism, Genetic; Protein Conformation; Protein Isoforms; Recombinant Proteins; Sertraline; Substrate Specificity	2020
Versatile applicability of a grid-based CYP3A4 Template to understand the interacting mechanisms with the small-size ligands; part 3 of CYP3A4 Template study. Drug metabolism and pharmacokinetics, 2020, Volume: 35, Issue:3 Topics: Coumarins; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Humans; Ketoconazole; Ligands; Mibefradil; Molecular Structure; Nicardipine	2020
Screening and verification of CYP3A4 inhibitors from Bushen-Yizhi formula to enhance the bioavailability of osthole in rat plasma. Journal of ethnopharmacology, 2022, Jan-10, Volume: 282 Topics: Animals; Antifungal Agents; Biological Availability; Coumarins; Cyclooctanes; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dioxoles; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Gene Expression Regulation, Enzymologic; Herb-Drug Interactions; Ketoconazole; Lignans; Male; Polycyclic Compounds; Random Allocation; Rats; Rats, Sprague-Dawley	2022