ketoconazole has been researched along with voriconazole in 114 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (0.88) | 18.2507 |
| 2000's | 46 (40.35) | 29.6817 |
| 2010's | 56 (49.12) | 24.3611 |
| 2020's | 11 (9.65) | 2.80 |
| Authors | Studies |
|---|---|
| Driscoll, MD; Lafite, P; Levy, C; Leys, D; Mast, N; McLean, KJ; Munro, AW; Pikuleva, IA; Rigby, SE | 1 |
| Emami, S; Keighobadi, M; Tavangar, P | 1 |
| Cheng, M; Hao, C; Jiang, X; Su, X; Wei, P; Wu, M; Zhang, X; Zhao, D; Zhao, L; Zhao, S | 1 |
| Wang, SQ; Wang, YF; Xu, Z | 1 |
| Cheng, M; Cui, H; Jiang, H; Li, S; Liu, L; Su, X; Sun, Y; Wu, T; Yin, W; Zhang, Y; Zhao, D; Zhao, L; Zheng, Y | 1 |
| Guengerich, FP; Hargrove, TY; Lepesheva, GI; Nes, WD; Rachakonda, G; Villalta, F; Wawrzak, Z | 1 |
| Abonía, R; Delgado, P; Enriz, RD; Garibotto, FM; Insuasty, B; Juárez, S; Nogueras, M; Quiroga, J; Rodero, L; Sortino, M; Zacchino, SA | 1 |
| Bergès, T; Bouchara, JP; Chabasse, D; Hennequin, C; Tronchin, G; Vandeputte, P | 1 |
| Cheng, S; Clancy, CJ; Clapp, W; Nguyen, KT; Nguyen, MH | 1 |
| Cao, YB; Jiang, YY; Sun, QY; Wu, QY; Xu, JM; Zhang, DZ; Zhang, J; Zhang, WN; Zhao, HQ | 1 |
| Kang, TH; Kim, S; Park, JS; Suh, YG; Yu, KA | 1 |
| Alvarado-Ramírez, E; Torres-Rodríguez, JM | 1 |
| Almyroudis, NG; Fothergill, AW; Kusne, S; Rinaldi, MG; Sutton, DA | 1 |
| Herrmann, JV; Miltenberger, R; Müller, FM; Salvenmoser, S; Staudigel, A; Tredup, A | 1 |
| Deising, HB; Serfling, A; Wohlrab, J | 1 |
| Calderone, R; Chauhan, N; Kruppa, M | 1 |
| Enriz, RD; Freile, M; Gupta, MP; Kouznetsov, VV; Sortino, M; Vargas Méndez, LY; Vásquez, Y; Zacchino, SA | 1 |
| Cano, J; Gené, J; Guarro, J; Marimon, R; Serena, C | 1 |
| Buitrago, MJ; Cuenca-Estrella, M; Gomez-Lopez, A; Gutierrez, MO; Rodriguez-Tudela, JL | 1 |
| Azor, M; Cano, J; Fothergill, AW; Gené, J; Guarro, J; Rinaldi, MG; Sutton, DA | 1 |
| Jiang, Y; Jin, Y; Li, P; Liu, P; Sun, P; Sun, Q; Wu, Q; Xie, W; Yang, X; Zhang, D; Zhang, Y; Zhu, S | 1 |
| Artico, M; Botta, M; Caporuscio, F; Cirilli, R; D'Auria, FD; De Melo, NR; Kelly, SL; La Regina, G; La Torre, F; Lamb, DC; Nencioni, L; Olla, S; Palamara, AT; Piscitelli, F; Silvestri, R; Tafi, A | 1 |
| Kelly, DE; Kelly, SL; Manning, NJ; Merkamm, M; Parker, JE; Pompon, D | 1 |
| Bergès, T; Bouchara, JP; Chabasse, D; Ernoult, E; Larcher, G; Tronchin, G; Vandeputte, P | 1 |
| Cannon, RD; Holmes, AR; Lamping, E; Nakamura, K; Niimi, K; Niimi, M; Ranchod, A; Tyndall, JD | 1 |
| Jackson, CJ; Kelly, DE; Kelly, SL; Lamb, DC; Marczylo, TH; Parker, JE; Warrilow, AG | 1 |
| Chai, X; Dan, Z; Hu, H; Jiang, Y; Sun, Q; Wu, Q; Yu, S; Zhang, J | 1 |
| Chai, X; Dan, Z; Hu, H; Wu, Q; Yu, S; Zhang, D; Zhang, J; Zhao, Q; Zou, Y | 1 |
| Bergès, T; Bouchara, JP; Chabasse, D; Renier, G; Rocher, F; Tronchin, G; Vandeputte, P | 1 |
| Gao, C; Pang, G; Sun, S; Wang, B; Xu, Y; Zhao, D; Zhou, L | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Bader, O; Gross, U; Kelly, DE; Kelly, SL; Martel, CM; Parker, JE; Warrilow, AG; Weig, M | 1 |
| Chai, X; Guan, Z; Hu, H; Sun, Q; Wu, Q; Yan, Y; Yu, S; Zou, Y | 1 |
| Bader, O; Gross, U; Kelly, DE; Kelly, SL; Martel, CM; Parker, JE; Rolley, N; Warrilow, AG; Weig, M | 1 |
| Ghosh, I; Manoharlal, R; Prakash, O; Prasad, R; Puri, N; Sharma, M | 1 |
| Cao, Y; Chai, X; Jiang, Y; Sun, Q; Wu, Q; Xu, J; Yu, S; Zhang, D; Zhang, J; Zou, Y | 1 |
| Chai, X; Hu, H; Liao, J; Wu, Q; Xu, M; Yu, S; Zhao, Q; Zou, Y | 1 |
| Avery, VM; Sykes, ML | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Chai, X; Ding, H; Li, L; Wang, B; Wu, Q; Yu, S; Zou, Y | 1 |
| Gerwick, WH; Kurtán, T; Liu, B; Mándi, A; Sun, P; Tang, H; Wang, ZW; Xu, DX; Zhang, W | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Chen, F; Di, H; Lan, L; Li, J; Lu, Y; Sheng, C; Wang, X; Wang, Y; Wei, H; Xiao, Q; Xu, Y; Zhang, L; Zhu, J | 1 |
| Chen, F; Di, H; Lan, L; Li, J; Lu, Y; Wang, X; Wang, Y; Wei, H; Xiao, Q; Xu, Y; Zhang, L; Zhu, J | 1 |
| Chen, F; Chen, W; Hu, L; Lan, L; Li, B; Li, J; Li, X; Lin, D; Liu, W; Liu, Y; Lu, Y; Mao, F; Ni, S; Qiu, X; Wang, M; Wei, H; Xu, Y; Zheng, X; Zhu, J | 1 |
| Chen, F; Chen, W; Lan, L; Li, B; Li, J; Liu, Y; Mao, F; Ni, S; Wei, H; Zhu, J | 1 |
| Benhamou, RI; Dorot, O; Elias, R; Fridman, M; Jaber, QZ; Oved, K; Pichinuk, E; Zada, SL | 1 |
| Nguyen, MH; Yu, CY | 1 |
| Crego, AL; Gómez, J; Lavandera, JL; Marina, ML | 1 |
| Hyland, R; Jones, BC; Smith, DA | 1 |
| del Palacio, A; Garau, M; Pereiro, M | 1 |
| Bliss, JM; Gigliotti, F; Wellington, M | 1 |
| Maertens, JA | 1 |
| Wark, P | 1 |
| Yasuda, MA | 1 |
| Alía-Aponte, C; Baró-Tomás, T; Jiménez-Cabello, T; Lázera, MS; Morera-López, Y; Torres-Rodríguez, JM | 1 |
| Niwa, T; Shiraga, T; Takagi, A | 1 |
| Bagg, J; Coulter, WA; Kuriyama, T; Lewis, MA; Ready, D; Williams, DW | 1 |
| Cepero de García, MC; Espinel-Ingroff, A; Rincón, S | 1 |
| Cano, J; Gené, J; Gilgado, F; Guarro, J; Serena, C | 1 |
| Costa, CR; de Araujo, CR; de Fátima Lisboa Fernandes, O; do Rosário Rodrigues Silva, M; Miranda, KC; Passos, XS | 1 |
| da Silva Barros, ME; de Assis Santos, D; Soares Hamdan, J | 1 |
| Ayadi, A; Ben Salah, S; Ben Zina, Z; Cheikrouhou, F; Colin, J; Feki, J; Makni, F; Mlik, M | 1 |
| Gupta, A; Mao, Q; Unadkat, JD | 1 |
| Carrillo-Muñoz, AJ; Casals, JB; del Valle, O; Estivill, MD; Ezkurra, PA; Giusiano, G; Quindós, G; Santos, P | 1 |
| Anderson, R; Steel, HC; Tintinger, GR | 1 |
| Nawrot, U; Nowicka, J; Wlodarczyk, K | 1 |
| Ambudkar, SV; Manoharlal, R; Prasad, R; Prasad, T; Puri, N; Sharma, M; Shukla, S | 1 |
| Brilhante, RS; Cordeiro, Rde A; de Camargo, ZP; de Lima, RA; Medrano, DJ; Monteiro, AJ; Rocha, MF; Sidrim, JJ; Tavares, JL | 1 |
| Avolio, M; Bruschetta, G; Camporese, A; De Rosa, R; Grosso, S | 1 |
| Accoceberry, I; Bernadou, JM; Breilh, D; Gordien, JB; Pigneux, A; Rouault, A; Saux, MC; Tabrizi, R; Vigouroux, S | 1 |
| Kelly, DE; Kelly, SL; Lamb, DC; Martel, CM; Melo, N; Nes, WD; Parker, JE; Warrilow, AG | 1 |
| Heeres, J; Lewi, P; Meerpoel, L | 1 |
| Alves, SH; Azevedo, MI; Botton, SA; Dutra, V; Jesus, FP; Lautert, C; Machado, ML; Mahl, DL; Santurio, JM; Zanette, RA | 1 |
| Meurman, JH; Pärnänen, P; Samaranayake, LP; Seneviratne, CJ; Vaara, M; Wong, SS; Yuen, KY | 1 |
| Al-Nawas, B; Karbach, J; Walter, C | 1 |
| Cafarchia, C; Figueredo, LA; Iatta, R; Montagna, MT; Otranto, D | 1 |
| Chen, TC; Chen, YC; Chen, YH; Lu, PL | 1 |
| Chen, Y; Groothuis, GM; Hadi, M; Merema, MT; Starokozhko, V | 1 |
| Inoue, A; Kaneko, H; Kawamura, A; Matsumoto, S; Ohbuchi, M; Usui, T; Yamazoe, Y; Yoshinari, K | 1 |
| Kelly, DE; Kelly, SL; Parker, JE; Warrilow, AG | 1 |
| Gärtner, P; Knoth, H; Petry, T | 1 |
| Gude, T; Kulkarni, MM; McGwire, BS; Reddy, N | 1 |
| Han, A; Hu, G; Kan, X; Lin, G; Qiu, X; Wang, C; Wang, Z; Xu, T | 1 |
| Cuenca-Estrella, M; Escribano, P; Guinea, J; Martín-Mazuelos, E; Pemán, J; Sánchez-Reus, F; Zaragoza, Ó | 1 |
| Kaithwas, G; Kishor, K; Sahu, RK; Saraf, SA; Singh, B | 1 |
| Chen, M; Chen, X; Hu, G; Hu, X; Huang, X; Li, X; Lin, Y; Wang, L; Wang, S | 1 |
| Cheung, BP; Samaranayake, LP; Samaranayake, YH; Yau, JY; Yeung, KW | 1 |
| Fong, PH; Lee, VH; Seneviratne, CJ; Wong, SS | 1 |
| Bulanda, M; Jagielski, T; Skóra, M | 1 |
| Abbas, MA; Ahmed, SA; Al-Hatmi, AM; de Hoog, GS; Jouvion, G; Kolecka, A; Mahgoub, el S | 1 |
| Cai, JP; Chen, M; Chen, X; Gu, E; Hu, G; Wang, L; Wang, S; Zheng, X; Zhou, H | 1 |
| Garvey, EP; Hoekstra, WJ; Kelly, DE; Kelly, SL; Nes, WD; Parker, JE; Price, CL; Schotzinger, RJ; Warrilow, AG | 1 |
| Holman, TR; Hughes, DD; Kelly, DE; Kelly, SL; Nes, WD; Parker, JE; Price, CL; Rolley, NJ; Smyrniotis, CJ; Thoss, V; Warrilow, AG | 1 |
| Abd Aziz, N; Kamaruzaman, S; Loh, SH; Nur, H; Sanagi, MM; Wan Ibrahim, WA; Yahaya, N | 1 |
| Garvey, EP; Hoekstra, WJ; Kelly, DE; Kelly, SL; Nes, WD; Parker, JE; Price, CL; Schotzinger, RJ; Warrilow, AGS; Wiederhold, NP | 1 |
| Abbasi, SA; Bokhari, H; Hussain, Z; Imran, M; Jamil, B; Khalid, T; Mukhtar Bokhari, MT; Mukhtar Bokhari, MZ; Saeed, A | 1 |
| Agarwal, T; Maharana, PK; Satpathy, G; Sharma, N; Singhal, D; Sinha, R; Titiyal, JS; Upadhyay, AD; Velpandian, T | 1 |
| Kamata, H; Kano, R; Kariya, N; Oshimo, K; Yokoi, S | 1 |
| Asif, MI; Maharana, PK; Sahay, P; Titiyal, JS | 1 |
| Agarwal, T; Bandivadekar, P; Chako, J; Maharana, PK; Sahay, P; Saluja, G; Satpathy, G; Sharma, N; Singhal, D; Sinha, R; Titiyal, JS; Velpandian, T | 1 |
| Shen, L; Tu, F; Wang, J; Wang, R; Xia, G; Xu, J; Ye, C; Yi, Y; Yu, C; Zheng, Z | 1 |
| Milanezi, ACM; VAN DER Sand, ST; Witusk, JPD | 1 |
| Bao, SS; Chen, MC; Chen, RJ; Cui, X; Dong, YY; Hu, GX; Lou, D; Pan, WH; Sun, W; Wang, Z | 1 |
| Chen, M; Chen, R; Chen, Y; Hu, G; Huang, C; Sun, W; Wang, Z; Zhang, X | 1 |
| Afsarian, MH; Ahmadi, B; Ansari, S; Ansari, Z; Lotfali, E; Norouzi, M; Rezaei-Matehkolaei, A | 1 |
| Harada, K; Inagaki, K; Kampirapap, K; Koga, H; Maeda, J; Makimura, K; Nanjoh, Y; Neki, D; Reangchainam, S; Tsuboi, R; Yuasa, K | 1 |
| Abou El-Alamin, MM; Aboul-Enein, HY; Atia, MA; Sultan, MA | 1 |
| Aala, F; Badali, H; Barac, A; Daie Ghazvini, R; Fatahi, N; Ghaffari, M; Hashemi, SJ; Izadi, A; Khodavaisy, S; Rezaie, S; Salehi, Z; Taran, M | 1 |
| Cheng, G; Huang, L; Li, T; Luo, X; Xue, X; Zhang, Y | 1 |
| Chen, RJ; Cheng, C; Cui, X; Huang, CK; Sun, W; Wang, J; Wang, Y; Wang, Z | 1 |
| Abastabar, M; Aghili, SR; Badali, H; Haghani, I; Hedayati, MT; Javidnia, J; Khojasteh, S; Meis, JF; Moazeni, M; Nargesi, S; Nosratabadi, M; Shabanzadeh, S; Shokohi, T; Zaedi, A | 1 |
| Alegre, L; Giusiano, G; Latorre, W; Mussin, J; Rojas, FD; Sosa, MLÁ | 1 |
| Geng, P; Han, A; Lu, Z; Song, X; Wang, S; Wang, Y; Wu, Q; Xia, M; Zhou, Q; Zhou, Y | 1 |
10 review(s) available for ketoconazole and voriconazole
| Article | Year |
|---|---|
An overview of azoles targeting sterol 14α-demethylase for antileishmanial therapy.
Topics: 14-alpha Demethylase Inhibitors; Antiprotozoal Agents; Azoles; Humans; Leishmania; Molecular Structure; Sterol 14-Demethylase | 2017 |
Tetrazole hybrids and their antifungal activities.
Topics: Animals; Antifungal Agents; Azoles; Fungi; Humans; Mycoses; Pyridines; Pyrimidines; Quinolines; Structure-Activity Relationship; Tetrazoles | 2019 |
Approaches to protozoan drug discovery: phenotypic screening.
Topics: Drug Discovery; Humans; Molecular Structure; Neglected Diseases; Phenotype; Plasmodium falciparum; Protozoan Infections; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma cruzi | 2013 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Antifungal pharmacotherapy for neonatal candidiasis.
Topics: Amphotericin B; Antifungal Agents; Candidiasis; Caspofungin; Cross Infection; Echinocandins; Fluconazole; Flucytosine; Fungal Proteins; Fungemia; Humans; Infant, Newborn; Infant, Premature; Intensive Care Units, Neonatal; Ketoconazole; Lipopeptides; Peptides; Peptides, Cyclic; Pyrimidines; Triazoles; Voriconazole | 2003 |
History of the development of azole derivatives.
Topics: Antifungal Agents; Azoles; Drug Resistance, Fungal; Fluconazole; Itraconazole; Ketoconazole; Pyrimidines; Triazoles; Voriconazole | 2004 |
Pathogenesis of allergic bronchopulmonary aspergillosis and an evidence-based review of azoles in treatment.
Topics: Antifungal Agents; Aspergillosis, Allergic Bronchopulmonary; Azoles; Evidence-Based Medicine; Forecasting; Humans; Itraconazole; Ketoconazole; Pyrimidines; Triazoles; Voriconazole | 2004 |
Pharmacological management of paracoccidioidomycosis.
Topics: Amphotericin B; Central Nervous System Fungal Infections; Drug Resistance; Fluconazole; Follow-Up Studies; Humans; Immunocompromised Host; Itraconazole; Ketoconazole; Paracoccidioidomycosis; Pyrimidines; Sulfonamides; Triazoles; Voriconazole | 2005 |
[Drug-drug interaction of antifungal drugs].
Topics: Antifungal Agents; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Echinocandins; Fluconazole; Humans; In Vitro Techniques; Itraconazole; Ketoconazole; Lipopeptides; Lipoproteins; Micafungin; Miconazole; Microsomes, Liver; Peptides, Cyclic; Pyrimidines; Triazoles; Voriconazole | 2005 |
Conazoles.
Topics: Antifungal Agents; Fluconazole; Itraconazole; Ketoconazole; Miconazole; Molecular Structure; Pyrimidines; Structure-Activity Relationship; Triazoles; Voriconazole | 2010 |
1 trial(s) available for ketoconazole and voriconazole
| Article | Year |
|---|---|
Comparison of Oral Voriconazole Versus Oral Ketoconazole as an Adjunct to Topical Natamycin in Severe Fungal Keratitis: A Randomized Controlled Trial.
Topics: Administration, Oral; Administration, Topical; Adult; Aged; Antifungal Agents; Chemotherapy, Adjuvant; Drug Therapy, Combination; Eye Infections, Fungal; Female; Humans; Keratitis; Ketoconazole; Male; Middle Aged; Natamycin; Ophthalmic Solutions; Tears; Visual Acuity; Voriconazole | 2017 |
103 other study(ies) available for ketoconazole and voriconazole
| Article | Year |
|---|---|
Structural and biochemical characterization of Mycobacterium tuberculosis CYP142: evidence for multiple cholesterol 27-hydroxylase activities in a human pathogen.
Topics: Cholesterol; Crystallography, X-Ray; Cytochrome P-450 Enzyme System; Host-Pathogen Interactions; Humans; Hydroxylation; Mycobacterium tuberculosis; Oxidation-Reduction; Protein Structure, Tertiary | 2010 |
Design, synthesis and evaluation of benzoheterocycle analogues as potent antifungal agents targeting CYP51.
Topics: Antifungal Agents; Aspergillus fumigatus; Binding Sites; Candida albicans; Catalytic Domain; Cryptococcus neoformans; Drug Design; Drug Resistance, Fungal; Drug Stability; Fluconazole; Fungal Proteins; Gas Chromatography-Mass Spectrometry; Humans; Microbial Sensitivity Tests; Molecular Docking Simulation; Protein Isoforms; Sterol 14-Demethylase; Sterols; Structure-Activity Relationship; Triazoles | 2018 |
Design, synthesis and evaluation of novel 5-phenylthiophene derivatives as potent fungicidal of Candida albicans and antifungal reagents of fluconazole-resistant fungi.
Topics: Antifungal Agents; Candida albicans; Dose-Response Relationship, Drug; Drug Design; Drug Resistance, Fungal; Fluconazole; Fungicides, Industrial; Humans; Microbial Sensitivity Tests; Molecular Structure; Structure-Activity Relationship; Thiophenes | 2021 |
Relaxed Substrate Requirements of Sterol 14α-Demethylase from
Topics: 14-alpha Demethylase Inhibitors; Ligands; Naegleria fowleri; Sterol 14-Demethylase; Substrate Specificity | 2021 |
Synthesis and antifungal activity of (Z)-5-arylidenerhodanines.
Topics: Antifungal Agents; Computer Simulation; Drug Design; Microbial Sensitivity Tests; Microwaves; Mitosporic Fungi; Molecular Structure; Rhodanine; Sensitivity and Specificity; Stereoisomerism; Structure-Activity Relationship; Yeasts | 2007 |
Reduced susceptibility to polyenes associated with a missense mutation in the ERG6 gene in a clinical isolate of Candida glabrata with pseudohyphal growth.
Topics: Antifungal Agents; Candida glabrata; Candidiasis; DNA Primers; Genes, Fungal; Genetic Complementation Test; Methyltransferases; Microbial Sensitivity Tests; Molecular Sequence Data; Mutation, Missense; Phenotype; Polyenes; Reverse Transcriptase Polymerase Chain Reaction; RNA, Fungal; RNA, Messenger; Sterols | 2007 |
A Candida albicans petite mutant strain with uncoupled oxidative phosphorylation overexpresses MDR1 and has diminished susceptibility to fluconazole and voriconazole.
Topics: Antifungal Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Candida albicans; Drug Resistance, Fungal; Fluconazole; Microbial Sensitivity Tests; Mutation; Oxidative Phosphorylation; Pyrimidines; Reverse Transcriptase Polymerase Chain Reaction; Triazoles; Voriconazole | 2007 |
Synthesis of novel triazole derivatives as inhibitors of cytochrome P450 14alpha-demethylase (CYP51).
Topics: Antifungal Agents; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Infrared; Triazoles | 2007 |
Discovery of novel indazole-linked triazoles as antifungal agents.
Topics: Administration, Oral; Animals; Antifungal Agents; Aspergillus; Candida; Disease Models, Animal; Indazoles; Mice; Microbial Sensitivity Tests; Rats; Stereoisomerism; Triazoles | 2007 |
In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods.
Topics: Amphotericin B; Antifungal Agents; Fluconazole; Flucytosine; Humans; In Vitro Techniques; Itraconazole; Ketoconazole; Microbial Sensitivity Tests; Pyrimidines; Quality Control; Sporothrix; Sporotrichosis; Triazoles; Voriconazole | 2007 |
In vitro susceptibilities of 217 clinical isolates of zygomycetes to conventional and new antifungal agents.
Topics: Amphotericin B; Antifungal Agents; Caspofungin; Echinocandins; Fluconazole; Flucytosine; Humans; In Vitro Techniques; Itraconazole; Ketoconazole; Lipopeptides; Microbial Sensitivity Tests; Mucormycosis; Peptides, Cyclic; Pyrimidines; Triazoles; Voriconazole | 2007 |
Cross-resistance to medical and agricultural azole drugs in yeasts from the oropharynx of human immunodeficiency virus patients and from environmental Bavarian vine grapes.
Topics: AIDS-Related Opportunistic Infections; Antifungal Agents; Azoles; Candida albicans; Candidiasis, Oral; Drug Resistance, Fungal; Environmental Microbiology; Fungicides, Industrial; Germany; HIV Infections; HIV-1; Humans; Microbial Sensitivity Tests; Oropharynx; Vitis | 2007 |
Treatment of a clinically relevant plant-pathogenic fungus with an agricultural azole causes cross-resistance to medical azoles and potentiates caspofungin efficacy.
Topics: Amphotericin B; Antifungal Agents; Azoles; Caspofungin; Colletotrichum; Drug Resistance, Fungal; Drug Synergism; Echinocandins; Fungi; Fungicides, Industrial; Humans; In Vitro Techniques; Lipopeptides; Microbial Sensitivity Tests; Microscopy, Fluorescence; Nystatin; Plant Diseases; Skin; Triazoles | 2007 |
The Ssk1p response regulator and Chk1p histidine kinase mutants of Candida albicans are hypersensitive to fluconazole and voriconazole.
Topics: Antifungal Agents; Candida albicans; Culture Media; Drug Resistance, Fungal; Fluconazole; Histidine Kinase; Microbial Sensitivity Tests; Mutation; Phenotype; Phosphorylation; Protein Kinases; Pyrimidines; Signal Transduction; Triazoles; Voriconazole | 2007 |
Antifungal and cytotoxic activities of some N-substituted aniline derivatives bearing a hetaryl fragment.
Topics: Aniline Compounds; Antifungal Agents; Antineoplastic Agents; Drug Screening Assays, Antitumor; Humans; Imines; Microbial Sensitivity Tests; Molecular Structure; National Cancer Institute (U.S.); United States | 2008 |
In vitro antifungal susceptibilities of five species of sporothrix.
Topics: Animals; Antifungal Agents; Drug Resistance, Fungal; Humans; Microbial Sensitivity Tests; Species Specificity; Sporothrix; Sporotrichosis | 2008 |
Reliability of the WIDERYST susceptibility testing system for detection of in vitro antifungal resistance in yeasts.
Topics: Amphotericin B; Antifungal Agents; Azoles; Candida; Culture Media; Drug Resistance, Fungal; Fungi; Humans; Microbial Sensitivity Tests; Mycoses; Reproducibility of Results; Yeasts | 2008 |
In vitro antifungal susceptibility and molecular characterization of clinical isolates of Fusarium verticillioides (F. moniliforme) and Fusarium thapsinum.
Topics: Animals; Antifungal Agents; Drug Resistance, Fungal; Fusarium; Humans; Microbial Sensitivity Tests; Molecular Sequence Data; Mycoses; Naphthalenes; Sequence Analysis, DNA; Terbinafine; Triazoles; Tubulin | 2008 |
Synthesis and SAR studies of biaryloxy-substituted triazoles as antifungal agents.
Topics: Antifungal Agents; Candida albicans; Fluconazole; Humans; Microbial Sensitivity Tests; Molecular Structure; Pyrimidines; Structure-Activity Relationship; Triazoles; Voriconazole; Yeasts | 2008 |
1-[(3-Aryloxy-3-aryl)propyl]-1H-imidazoles, new imidazoles with potent activity against Candida albicans and dermatophytes. Synthesis, structure-activity relationship, and molecular modeling studies.
Topics: Antifungal Agents; Arthrodermataceae; Candida albicans; Cell Line, Tumor; Cell Survival; Computer Simulation; Humans; Imidazoles; Models, Molecular; Molecular Structure; Stereoisomerism; Structure-Activity Relationship | 2008 |
Differential azole antifungal efficacies contrasted using a Saccharomyces cerevisiae strain humanized for sterol 14 alpha-demethylase at the homologous locus.
Topics: Antifungal Agents; Azoles; Base Sequence; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DNA, Fungal; Drug Resistance, Fungal; Genes, Fungal; Humans; Molecular Sequence Data; Recombinant Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Species Specificity; Sterol 14-Demethylase | 2008 |
A nonsense mutation in the ERG6 gene leads to reduced susceptibility to polyenes in a clinical isolate of Candida glabrata.
Topics: Antifungal Agents; Azoles; Base Sequence; Candida glabrata; Candidiasis; Codon, Nonsense; DNA, Fungal; Drug Resistance, Fungal; Ergosterol; Genes, Fungal; Guanine; Humans; Molecular Sequence Data; Polyenes | 2008 |
Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei.
Topics: Amino Acid Sequence; Animals; Antifungal Agents; ATP-Binding Cassette Transporters; Azoles; Blotting, Northern; Blotting, Southern; Candida; Candidiasis; Cell Membrane; Chromosomes, Fungal; Drug Resistance, Fungal; Endoplasmic Reticulum; Humans; Phenotype; Plasmids; Reverse Transcriptase Polymerase Chain Reaction; Saccharomyces cerevisiae | 2009 |
Identification, characterization, and azole-binding properties of Mycobacterium smegmatis CYP164A2, a homolog of ML2088, the sole cytochrome P450 gene of Mycobacterium leprae.
Topics: Amino Acid Motifs; Amino Acid Sequence; Azoles; Base Sequence; Cloning, Molecular; Conserved Sequence; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Genes, Bacterial; Hydrogen-Ion Concentration; Molecular Sequence Data; Molecular Structure; Molecular Weight; Mycobacterium leprae; Mycobacterium smegmatis; Osmolar Concentration; Recombinant Proteins; Sequence Homology, Amino Acid; Sodium Chloride | 2009 |
Design, synthesis, and biological evaluation of novel triazole derivatives as inhibitors of cytochrome P450 14alpha-demethylase.
Topics: Antifungal Agents; Aspergillus fumigatus; Cytochrome P-450 Enzyme Inhibitors; Drug Design; Enzyme Inhibitors; Protein Binding; Sterol 14-Demethylase; Structure-Activity Relationship; Triazoles | 2009 |
Design, synthesis, and biological evaluation of novel 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-substituted benzylamino-2-propanols.
Topics: Antifungal Agents; Catalytic Domain; Chemistry, Pharmaceutical; Computer Simulation; Crystallography, X-Ray; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Design; Fluconazole; Fungal Proteins; Microbial Sensitivity Tests; Models, Chemical; Propanols; Protein Binding; Triazoles | 2009 |
Hypersusceptibility to azole antifungals in a clinical isolate of Candida glabrata with reduced aerobic growth.
Topics: Adult; Aerobiosis; Antifungal Agents; Azoles; Candida glabrata; Chromatography, High Pressure Liquid; Ergosterol; Female; Flow Cytometry; Genes, Fungal; Humans; Microbial Sensitivity Tests; Microscopy, Electron, Transmission; Molecular Sequence Data; Polyenes | 2009 |
In vitro activity of thimerosal against ocular pathogenic fungi.
Topics: Alternaria; Amphotericin B; Antifungal Agents; Aspergillus; Eye Infections, Fungal; Fungi; Fusarium; Humans; Microbial Sensitivity Tests; Natamycin; Thimerosal | 2010 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
A clinical isolate of Candida albicans with mutations in ERG11 (encoding sterol 14alpha-demethylase) and ERG5 (encoding C22 desaturase) is cross resistant to azoles and amphotericin B.
Topics: Amphotericin B; Antifungal Agents; Azoles; Candida albicans; Drug Resistance, Fungal; Fungal Proteins; Microbial Sensitivity Tests; Mutation; Polymerase Chain Reaction | 2010 |
Synthesis and antifungal evaluation of novel triazole derivatives as inhibitors of cytochrome P450 14alpha-demethylase.
Topics: 14-alpha Demethylase Inhibitors; Antifungal Agents; Fungi; Humans; Models, Molecular; Mycoses; Sterol 14-Demethylase; Triazoles | 2010 |
Identification and characterization of four azole-resistant erg3 mutants of Candida albicans.
Topics: Amphotericin B; Antifungal Agents; Azoles; Candida albicans; Clotrimazole; Drug Resistance, Fungal; Ergosterol; Fluconazole; Itraconazole; Ketoconazole; Microbial Sensitivity Tests; Mutation; Oxidoreductases; Pyrimidines; Triazoles; Voriconazole | 2010 |
Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans.
Topics: Candida albicans; Membrane Transport Proteins; Saccharomyces cerevisiae; Structure-Activity Relationship; Substrate Specificity | 2010 |
Design, synthesis and antifungal activities of novel 1,2,4-triazole derivatives.
Topics: Antifungal Agents; Candida albicans; Catalytic Domain; Cryptococcus neoformans; Cytochrome P-450 Enzyme Inhibitors; Drug Design; Fluconazole; Fungal Proteins; Microbial Sensitivity Tests; Molecular Docking Simulation; Piperazines; Sterol 14-Demethylase; Structure-Activity Relationship; Triazoles; Voriconazole | 2011 |
New triazole derivatives as antifungal agents: synthesis via click reaction, in vitro evaluation and molecular docking studies.
Topics: Antifungal Agents; Catalysis; Catalytic Domain; Click Chemistry; Computer Simulation; Copper; Fungi; Humans; Microbial Sensitivity Tests; Triazoles | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Synthesis and evaluation of novel azoles as potent antifungal agents.
Topics: Antifungal Agents; Azoles; Dose-Response Relationship, Drug; Fungi; Microbial Sensitivity Tests; Molecular Structure; Structure-Activity Relationship | 2014 |
Polyhydroxy cyclohexanols from a Dendrodochium sp. fungus associated with the sea cucumber Holothuria nobilis Selenka.
Topics: Animals; Antifungal Agents; Cryptococcus neoformans; Cyclohexanols; Holothuria; Humans; Microbial Sensitivity Tests; Molecular Structure; Oceans and Seas; Trichophyton | 2014 |
Discovery of Potent Benzofuran-Derived Diapophytoene Desaturase (CrtN) Inhibitors with Enhanced Oral Bioavailability for the Treatment of Methicillin-Resistant Staphylococcus aureus (MRSA) Infections.
Topics: Administration, Oral; Animals; Anti-Bacterial Agents; Bacterial Proteins; Benzofurans; Biological Availability; Drug Discovery; Enzyme Inhibitors; Female; Male; Methicillin-Resistant Staphylococcus aureus; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Oxidoreductases; Rats; Rats, Sprague-Dawley; Staphylococcal Infections; Tissue Distribution | 2016 |
Discovery of Benzocycloalkane Derivatives Efficiently Blocking Bacterial Virulence for the Treatment of Methicillin-Resistant S. aureus (MRSA) Infections by Targeting Diapophytoene Desaturase (CrtN).
Topics: Alkanes; Anti-Bacterial Agents; Antifungal Agents; Dose-Response Relationship, Drug; Drug Discovery; Enzyme Inhibitors; Fungi; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Molecular Structure; Oxidoreductases; Staphylococcal Infections; Structure-Activity Relationship | 2016 |
Novel Inhibitors of Staphyloxanthin Virulence Factor in Comparison with Linezolid and Vancomycin versus Methicillin-Resistant, Linezolid-Resistant, and Vancomycin-Intermediate Staphylococcus aureus Infections in Vivo.
Topics: Animals; Anti-Bacterial Agents; Antifungal Agents; Drug Resistance, Bacterial; Ether-A-Go-Go Potassium Channels; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Potassium Channel Blockers; Rats; Rats, Sprague-Dawley; Staphylococcal Infections; Structure-Activity Relationship; Vancomycin; Vancomycin Resistance; Xanthophylls | 2017 |
Novel Terminal Bipheny-Based Diapophytoene Desaturases (CrtN) Inhibitors as Anti-MRSA/VISR/LRSA Agents with Reduced hERG Activity.
Topics: Animals; Drug Design; Enzyme Inhibitors; ERG1 Potassium Channel; HEK293 Cells; Hep G2 Cells; Humans; Inhibitory Concentration 50; Methicillin-Resistant Staphylococcus aureus; Mice; Oxidoreductases; Rats; Safety; Solubility; Structure-Activity Relationship; Water | 2018 |
Antifungal activity, mode of action variability, and subcellular distribution of coumarin-based antifungal azoles.
Topics: Antifungal Agents; Azoles; Candida; Cell Survival; Coumarins; Dose-Response Relationship, Drug; HEK293 Cells; Hep G2 Cells; Humans; Microbial Sensitivity Tests; Molecular Structure; Optical Imaging; Structure-Activity Relationship | 2019 |
Voriconazole against fluconazole-susceptible and resistant candida isolates: in-vitro efficacy compared with that of itraconazole and ketoconazole.
Topics: Antifungal Agents; Candida; Drug Resistance, Microbial; Drug Resistance, Multiple; Fluconazole; Humans; Itraconazole; Ketoconazole; Microbial Sensitivity Tests; Pyrimidines; Triazoles; Voriconazole | 1998 |
Application of capillary zone electrophoresis with off-line solid-phase extraction to in vitro metabolism studies of antifungals.
Topics: Acetic Acid; Acetonitriles; Antifungal Agents; Clotrimazole; Drug Stability; Electrophoresis, Capillary; Fluconazole; Humans; Itraconazole; Ketoconazole; Methanol; Microsomes, Liver; Molecular Structure; Molecular Weight; Pyrimidines; Reproducibility of Results; Sensitivity and Specificity; Solvents; Triazoles; Verapamil; Voriconazole | 2001 |
Identification of the cytochrome P450 enzymes involved in the N-oxidation of voriconazole.
Topics: Antifungal Agents; Chromatography, High Pressure Liquid; Cyclic N-Oxides; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Humans; In Vitro Techniques; Ketoconazole; Microsomes, Liver; Oxidation-Reduction; Pyrimidines; Quinidine; Sulfaphenazole; Theophylline; Triazoles; Voriconazole | 2003 |
In vitro susceptibilities of Malassezia species to a new triazole, albaconazole (UR-9825), and other antifungal compounds.
Topics: Antifungal Agents; Drug Resistance, Fungal; Fluconazole; Flucytosine; In Vitro Techniques; Itraconazole; Ketoconazole; Malassezia; Microbial Sensitivity Tests; Pyrimidines; Quinazolines; Triazoles; Voriconazole | 2003 |
DNA fingerprinting pattern and susceptibility to antifungal drugs in Cryptococcus neoformans variety grubii isolates from Barcelona city and rural environmental samples.
Topics: Amphotericin B; Antifungal Agents; Cryptococcus neoformans; DNA Fingerprinting; DNA, Fungal; Drug Resistance, Fungal; Fluconazole; Itraconazole; Ketoconazole; Microbial Sensitivity Tests; Pyrimidines; Soil Microbiology; Spain; Triazoles; Voriconazole | 2005 |
In vitro susceptibility of oral Candida to seven antifungal agents.
Topics: Amphotericin B; Antifungal Agents; Candida; Candida albicans; Candida glabrata; Candida tropicalis; Candidiasis, Oral; Drug Resistance, Fungal; Fluconazole; Humans; Itraconazole; Ketoconazole; Miconazole; Mouth Diseases; Nystatin; Pyrimidines; Triazoles; Voriconazole | 2005 |
A modified Christensen's urea and CLSI broth microdilution method for testing susceptibilities of six Malassezia species to voriconazole, itraconazole, and ketoconazole.
Topics: AIDS-Related Opportunistic Infections; Antifungal Agents; Culture Media; Dermatomycoses; HIV Infections; Humans; Itraconazole; Ketoconazole; Malassezia; Microbial Sensitivity Tests; Polysorbates; Pyrimidines; Triazoles; Urea; Voriconazole | 2006 |
Antifungal susceptibilities of the species of the Pseudallescheria boydii complex.
Topics: Amphotericin B; Antifungal Agents; Candida; Drug Resistance, Fungal; Echinocandins; Fluconazole; Flucytosine; Humans; Itraconazole; Ketoconazole; Lipopeptides; Lipoproteins; Micafungin; Microbial Sensitivity Tests; Naphthalenes; Peptides, Cyclic; Pseudallescheria; Pyrimidines; Quality Control; Quinazolines; Scedosporium; Terbinafine; Thiazoles; Triazoles; Voriconazole | 2006 |
Antifungal activities of azole agents against the Malassezia species.
Topics: Antifungal Agents; Azoles; Fluconazole; Humans; In Vitro Techniques; Itraconazole; Ketoconazole; Malassezia; Microbial Sensitivity Tests; Pyrimidines; Tinea Versicolor; Triazoles; Voriconazole | 2007 |
Antifungal susceptibility testing of Trichophyton rubrum by E-test.
Topics: Antifungal Agents; Cells, Cultured; Drug Resistance, Fungal; Fluconazole; Humans; Itraconazole; Ketoconazole; Microbial Sensitivity Tests; Pyrimidines; Tinea; Triazoles; Trichophyton; Voriconazole | 2007 |
[Acanthamoeba keratitis: about the first two Tunisian cases].
Topics: Acanthamoeba; Acanthamoeba Keratitis; Adult; Amebicides; Animals; Antifungal Agents; Benzamidines; Biguanides; Contact Lenses, Hydrophilic; Drug Therapy, Combination; Eye Infections, Fungal; Female; Fusarium; Humans; Keratoplasty, Penetrating; Ketoconazole; Pyrimidines; Triazoles; Tunisia; Voriconazole | 2007 |
Interactions of azole antifungal agents with the human breast cancer resistance protein (BCRP).
Topics: Antifungal Agents; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Cell Line; Cell Survival; Chlorophyll; Dose-Response Relationship, Drug; Drug Interactions; Drug Resistance, Neoplasm; Flow Cytometry; Fluconazole; Fluorescent Dyes; Humans; Inhibitory Concentration 50; Itraconazole; Ketoconazole; Neoplasm Proteins; Pyrimidines; Topotecan; Transfection; Triazoles; Voriconazole | 2007 |
Activity of caspofungin and voriconazole against clinical isolates of Candida and other medically important yeasts by the CLSI M-44A disk diffusion method with Neo-Sensitabs tablets.
Topics: Amphotericin B; Antifungal Agents; Candida; Caspofungin; Cryptococcus; Disk Diffusion Antimicrobial Tests; Drug Resistance, Fungal; Echinocandins; Fluconazole; Itraconazole; Ketoconazole; Lipopeptides; Pyrimidines; Rhodotorula; Triazoles; Trichosporon; Voriconazole | 2008 |
Comparison of the anti-inflammatory activities of imidazole antimycotics in relation to molecular structure.
Topics: Anti-Inflammatory Agents; Antifungal Agents; Cells, Cultured; Fluconazole; Humans; Imidazoles; Itraconazole; Ketoconazole; Leukotriene B4; Molecular Structure; Neutrophils; Platelet Activating Factor; Pyrimidines; Triazoles; Voriconazole | 2008 |
Susceptibility to voriconazole, fluconazole, and ketoconazole of yeast isolated from patients with hematological malignancies.
Topics: Antifungal Agents; Candida; Candidiasis; Drug Resistance, Fungal; Fluconazole; Hematologic Neoplasms; Humans; Ketoconazole; Microbial Sensitivity Tests; Pyrimidines; Triazoles; Voriconazole | 2008 |
Curcumin modulates efflux mediated by yeast ABC multidrug transporters and is synergistic with antifungals.
Topics: Anisomycin; Antifungal Agents; Biological Transport; Candida albicans; Curcumin; Cycloheximide; Drug Synergism; Enzyme Inhibitors; Fluconazole; Itraconazole; Ketoconazole; Methotrexate; Miconazole; Multidrug Resistance-Associated Proteins; Pyrimidines; Rhodamines; Saccharomyces cerevisiae; Triazoles; Voriconazole | 2009 |
In vitro synergistic effects of antituberculous drugs plus antifungals against Coccidioides posadasii.
Topics: Amphotericin B; Antifungal Agents; Antitubercular Agents; Caspofungin; Coccidioides; Coccidioidomycosis; Drug Synergism; Echinocandins; Ethambutol; Fluconazole; Humans; Isoniazid; Itraconazole; Ketoconazole; Lipopeptides; Microbial Sensitivity Tests; Pyrazinamide; Pyrimidines; Triazoles; Voriconazole | 2009 |
Direct antifungal susceptibility testing of positive Candida blood cultures by sensititre YeastOne.
Topics: Amphotericin B; Antifungal Agents; Candida; Candidiasis; Drug Resistance, Fungal; Fluconazole; Flucytosine; Humans; Itraconazole; Ketoconazole; Microbial Sensitivity Tests; Pyrimidines; Reagent Kits, Diagnostic; Sensitivity and Specificity; Time Factors; Triazoles; Voriconazole | 2009 |
Simultaneous determination of five systemic azoles in plasma by high-performance liquid chromatography with ultraviolet detection.
Topics: Calibration; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Drug Monitoring; Drug Stability; Fluconazole; Humans; Itraconazole; Ketoconazole; Pyrimidines; Quality Control; Reproducibility of Results; Spectrophotometry, Ultraviolet; Time Factors; Triazoles; Ultraviolet Rays; Voriconazole | 2009 |
Azole binding properties of Candida albicans sterol 14-alpha demethylase (CaCYP51).
Topics: Antifungal Agents; Azoles; Candida albicans; Econazole; Fluconazole; Itraconazole; Ketoconazole; Miconazole; Protein Binding; Pyrimidines; Sterol 14-Demethylase; Triazoles; Voriconazole | 2010 |
In vitro susceptibility of fluconazole-susceptible and -resistant isolates of Malassezia pachydermatis against azoles.
Topics: Antifungal Agents; Drug Resistance, Fungal; Fluconazole; Itraconazole; Ketoconazole; Malassezia; Microbial Sensitivity Tests; Pyrimidines; Triazoles; Voriconazole | 2011 |
Antifungal susceptibility and virulence attributes of bloodstream isolates of Candida from Hong Kong and Finland.
Topics: Amphotericin B; Antifungal Agents; Candida; Candidemia; Caspofungin; Drug Resistance, Fungal; Echinocandins; Finland; Fluconazole; Flucytosine; Hemolysin Proteins; Hong Kong; Humans; Itraconazole; Ketoconazole; Lipopeptides; Microbial Sensitivity Tests; Peptide Hydrolases; Pyrimidines; Triazoles; Virulence Factors; Voriconazole | 2011 |
Evaluation of saliva flow rates, Candida colonization and susceptibility of Candida strains after head and neck radiation.
Topics: Adult; Aged; Aged, 80 and over; Amphotericin B; Antifungal Agents; Candida; Candida albicans; Colony Count, Microbial; Dental Caries; Drug Resistance, Fungal; Female; Fluconazole; Head and Neck Neoplasms; Humans; Ketoconazole; Male; Microbial Sensitivity Tests; Middle Aged; Mouth; Pyrimidines; Radiation Injuries; Saliva; Salivary Glands; Secretory Rate; Triazoles; Voriconazole; Xerostomia | 2012 |
In vitro antifungal susceptibility of Malassezia pachydermatis from dogs with and without skin lesions.
Topics: Animals; Antifungal Agents; Dermatomycoses; Dog Diseases; Dogs; Fluconazole; Itraconazole; Ketoconazole; Malassezia; Miconazole; Naphthalenes; Pyrimidines; Terbinafine; Triazoles; Voriconazole | 2012 |
Fluconazole exposure rather than clonal spreading is correlated with the emergence of Candida glabrata with cross-resistance to triazole antifungal agents.
Topics: Amphotericin B; Antifungal Agents; Candida glabrata; Caspofungin; Drug Resistance, Fungal; Echinocandins; Fluconazole; Itraconazole; Ketoconazole; Lipopeptides; Microbial Sensitivity Tests; Pyrimidines; Triazoles; Voriconazole | 2012 |
Mouse precision-cut liver slices as an ex vivo model to study idiosyncratic drug-induced liver injury.
Topics: Animals; Benzodiazepines; Biomarkers; Carbamazepine; Cell Survival; Chemical and Drug Induced Liver Injury; Chemokines; Chromans; Clozapine; Cytokines; Diclofenac; Drug Synergism; Female; Glutathione; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; In Vitro Techniques; Ketoconazole; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Nitrogen Oxides; Olanzapine; Pyrimidines; Thiazolidinediones; Triazoles; Troglitazone; Voriconazole | 2012 |
Coordinated roles of pregnane X receptor and constitutive androstane receptor in autoinduction of voriconazole metabolism in mice.
Topics: Animals; Antifungal Agents; Aryl Hydrocarbon Hydroxylases; Constitutive Androstane Receptor; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Gene Expression Regulation; Hepatocytes; Host Specificity; Humans; Ketoconazole; Liver; Membrane Proteins; Mice; Mice, Transgenic; Oxidoreductases, N-Demethylating; Pregnane X Receptor; Primary Cell Culture; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; RNA, Messenger; Species Specificity; Triazoles; Voriconazole | 2013 |
Azole affinity of sterol 14α-demethylase (CYP51) enzymes from Candida albicans and Homo sapiens.
Topics: Antifungal Agents; Candida albicans; Clotrimazole; Escherichia coli; Fluconazole; Fungal Proteins; Humans; Itraconazole; Ketoconazole; Kinetics; Lanosterol; NADP; Protein Binding; Pyrimidines; Recombinant Proteins; Species Specificity; Sterol 14-Demethylase; Triazoles; Voriconazole | 2013 |
Differential pulse polarographic investigation of the antifungal drugs itraconazole, ketoconazole, fluconazole and voriconazole using a dropping mercury electrode.
Topics: Antifungal Agents; Electrochemistry; Electrodes; Fluconazole; Hydrogen-Ion Concentration; Indicators and Reagents; Itraconazole; Ketoconazole; Mercury; Polarography; Pyrimidines; Reference Standards; Reproducibility of Results; Triazoles; Voriconazole | 2012 |
Voriconazole suppresses the growth of Leishmania species in vitro.
Topics: Animals; Antiprotozoal Agents; Fluconazole; Inhibitory Concentration 50; Ketoconazole; Leishmania; Parasitic Sensitivity Tests; Pyrimidines; Species Specificity; Triazoles; Voriconazole | 2013 |
Differential effects of ketoconazole, itraconazole and voriconazole on the pharmacokinetics of imatinib and its main metabolite GCP74588 in rat.
Topics: Animals; Antifungal Agents; Benzamides; Drug Interactions; Imatinib Mesylate; Itraconazole; Ketoconazole; Male; Piperazines; Pyrimidines; Random Allocation; Rats; Rats, Sprague-Dawley; Voriconazole | 2014 |
Molecular identification and antifungal susceptibility of yeast isolates causing fungemia collected in a population-based study in Spain in 2010 and 2011.
Topics: Antifungal Agents; Candida; Candida albicans; Candida glabrata; Candida tropicalis; Candidiasis; Drug Resistance, Fungal; Echinocandins; Fungemia; Humans; Itraconazole; Ketoconazole; Microbial Sensitivity Tests; Pyrimidines; Spain; Triazoles; Voriconazole | 2014 |
Photochemical toxicity of drugs intended for ocular use.
Topics: Animals; Anti-Bacterial Agents; Antifungal Agents; Chickens; Diclofenac; Eye Diseases; Humans; Irritants; Ketoconazole; Ketorolac; Ophthalmic Solutions; Photochemical Processes; Sulfacetamide; Voriconazole | 2014 |
Inhibitory effect of ketoconazole and voriconazole on the pharmacokinetics of carvedilol in rats.
Topics: Animals; Antifungal Agents; Antihypertensive Agents; Area Under Curve; Carbazoles; Carvedilol; Chromatography, High Pressure Liquid; Drug Interactions; Half-Life; Ketoconazole; Male; Metabolic Clearance Rate; Propanolamines; Random Allocation; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry; Voriconazole | 2015 |
Genotypic, phenotypic, and proteomic characterization of Candida glabrata during sequential fluconazole exposure.
Topics: Antifungal Agents; Candida glabrata; Chromosomes, Fungal; Copper Sulfate; Culture Media; Drug Resistance, Fungal; Fluconazole; Fungal Proteins; Genotype; Hemolysin Proteins; Humans; Itraconazole; Ketoconazole; Metallothionein; Phenotype; Proteome; Virulence; Voriconazole | 2011 |
Antifungal susceptibility and phenotypic characterization of oral isolates of a black fungus from a nasopharyngeal carcinoma patient under radiotherapy.
Topics: Amphotericin B; Antifungal Agents; Biofilms; Carcinoma; Caspofungin; Chemoradiotherapy; Chemotherapy, Adjuvant; Drug Resistance, Fungal; Echinocandins; Exophiala; Fluconazole; Humans; Immunocompromised Host; Itraconazole; Ketoconazole; Lipopeptides; Male; Middle Aged; Mouth Diseases; Nasopharyngeal Neoplasms; Neoplasm Recurrence, Local; Opportunistic Infections; Phaeohyphomycosis; Radiotherapy, Intensity-Modulated; Voriconazole | 2015 |
In vitro activities of a wide panel of antifungal drugs against various Scopulariopsis and Microascus species.
Topics: Amphotericin B; Antifungal Agents; Ascomycota; Caspofungin; Drug Resistance, Fungal; Echinocandins; Fluconazole; Flucytosine; Itraconazole; Ketoconazole; Lipopeptides; Microbial Sensitivity Tests; Scopulariopsis; Triazoles; Voriconazole | 2015 |
Seventeen years of subcutaneous infection by Aspergillus flavus; eumycetoma confirmed by immunohistochemistry.
Topics: Antifungal Agents; Aspergillosis; Aspergillus flavus; Chronic Disease; Delayed Diagnosis; Diagnostic Errors; Foot Dermatoses; Humans; Immunohistochemistry; Itraconazole; Ketoconazole; Male; Microbial Sensitivity Tests; Middle Aged; Mycetoma; Radiography; Scedosporium; Subcutaneous Tissue; Sudan; Voriconazole | 2015 |
Evaluation of the Effects of Ketoconazole and Voriconazole on the Pharmacokinetics of Oxcarbazepine and Its Main Metabolite MHD in Rats by UPLC-MS-MS.
Topics: Animals; Anticonvulsants; Antifungal Agents; Biotransformation; Carbamazepine; Chromatography, High Pressure Liquid; Diazepam; Drug Combinations; Drug Interactions; Ketoconazole; Limit of Detection; Male; Oxcarbazepine; Prodrugs; Rats; Rats, Sprague-Dawley; Reference Standards; Reproducibility of Results; Tandem Mass Spectrometry; Voriconazole | 2016 |
The Investigational Drug VT-1129 Is a Highly Potent Inhibitor of Cryptococcus Species CYP51 but Only Weakly Inhibits the Human Enzyme.
Topics: Antifungal Agents; Clotrimazole; Cryptococcus; Enzyme Activation; Ergosterol; Fluconazole; Humans; Itraconazole; Ketoconazole; Lanosterol; Pyridines; Sterol 14-Demethylase; Tetrazoles; Voriconazole | 2016 |
Azole Antifungal Sensitivity of Sterol 14α-Demethylase (CYP51) and CYP5218 from Malassezia globosa.
Topics: Antifungal Agents; Azoles; Candida albicans; Clotrimazole; Cytochrome P450 Family 51; Drug Evaluation, Preclinical; Fluconazole; Fungal Proteins; Itraconazole; Ketoconazole; Kinetics; Lipids; Malassezia; Spectrophotometry; Sterol 14-Demethylase; Sterols; Voriconazole | 2016 |
A rapid MCM-41 dispersive micro-solid phase extraction coupled with LC/MS/MS for quantification of ketoconazole and voriconazole in biological fluids.
Topics: Antifungal Agents; Chromatography, High Pressure Liquid; Humans; Ketoconazole; Limit of Detection; Silicon Dioxide; Solid Phase Microextraction; Tandem Mass Spectrometry; Voriconazole | 2017 |
The Tetrazole VT-1161 Is a Potent Inhibitor of Trichophyton rubrum through Its Inhibition of T. rubrum CYP51.
Topics: Antifungal Agents; Azoles; Candida albicans; Clotrimazole; Drug Resistance, Fungal; Fluconazole; Fungal Proteins; Itraconazole; Ketoconazole; Microbial Sensitivity Tests; Pyridines; Sterol 14-Demethylase; Substrate Specificity; Tetrazoles; Trichophyton; Voriconazole | 2017 |
Candidiasis: Prevalence and resistance profiling in a tertiary care hospital of Pakistan.
Topics: Amphotericin B; Antifungal Agents; Candida albicans; Candida glabrata; Candidiasis; Cross-Sectional Studies; Drug Resistance, Fungal; Fluconazole; Humans; Ketoconazole; Kidney Failure, Chronic; Kidney Transplantation; Microbial Sensitivity Tests; Pakistan; Prevalence; Prospective Studies; Tertiary Care Centers; Voriconazole | 2017 |
Multi-azole-resistant strain of Malassezia pachydermatis isolated from a canine Malassezia dermatitis.
Topics: Animals; Antifungal Agents; Azoles; Cytochrome P-450 Enzyme System; Dermatitis; Dermatomycoses; Dog Diseases; Dogs; Drug Resistance, Multiple, Fungal; Drug Synergism; Fluconazole; Ketoconazole; Malassezia; Microbial Sensitivity Tests; Mutation, Missense; Open Reading Frames; Voriconazole | 2019 |
Periocular contact dermatitis with use of topical voriconazole 1% in mycotic keratitis.
Topics: Administration, Oral; Adult; Antifungal Agents; Aspergillus flavus; Corneal Ulcer; Dermatitis, Contact; Eye Infections, Fungal; Humans; Ketoconazole; Ophthalmic Solutions; Voriconazole | 2018 |
Management Algorithm for Fungal Keratitis: The TST (Topical, Systemic, and Targeted Therapy) Protocol.
Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Algorithms; Antifungal Agents; Child; Child, Preschool; Eye Infections, Fungal; Female; Humans; Infant; Injections, Intraocular; Keratitis; Ketoconazole; Male; Middle Aged; Natamycin; Ophthalmic Solutions; Prospective Studies; Visual Acuity; Voriconazole; Young Adult | 2019 |
Inhibitory effect of isavuconazole, ketoconazole, and voriconazole on the pharmacokinetics of methadone in vivo and in vitro.
Topics: Analgesics, Opioid; Animals; Antifungal Agents; Ketoconazole; Male; Methadone; Nitriles; Pyridines; Rats, Sprague-Dawley; Triazoles; Voriconazole | 2019 |
Antifungal susceptibility of yeasts isolated from anthropogenic watershed.
Topics: Amphotericin B; Antifungal Agents; Drug Resistance, Fungal; Fluconazole; Fresh Water; Itraconazole; Ketoconazole; Microbial Sensitivity Tests; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Reference Values; Sequence Analysis, DNA; Voriconazole; Yeasts | 2019 |
Effects of ketoconazole, voriconazole, and itraconazole on the pharmacokinetics of apatinib in rats.
Topics: Animals; Antifungal Agents; Antineoplastic Agents; Drug Evaluation, Preclinical; Drug Interactions; Drug Monitoring; Itraconazole; Ketoconazole; Male; Mycoses; Pyridines; Rats; Rats, Sprague-Dawley; Stomach Neoplasms; Voriconazole | 2019 |
Comparison of the inhibitory effect of ketoconazole, voriconazole, fluconazole, and itraconazole on the pharmacokinetics of bosentan and its corresponding active metabolite hydroxy bosentan in rats.
Topics: Animals; Antifungal Agents; Antihypertensive Agents; Bosentan; Drug Interactions; Fluconazole; Itraconazole; Ketoconazole; Male; Rats; Rats, Sprague-Dawley; Triazoles; Voriconazole | 2020 |
Topics: Antifungal Agents; Base Sequence; Epidermophyton; Humans; Iran; Itraconazole; Ketoconazole; Microbial Sensitivity Tests; Terbinafine; Tinea; Trichophyton; Voriconazole | 2019 |
In vitro antifungal activity of luliconazole against nondermatophytic moulds.
Topics: Amphotericin B; Antifungal Agents; Clotrimazole; Fluconazole; Fungi; Humans; Imidazoles; Itraconazole; Ketoconazole; Miconazole; Microbial Sensitivity Tests; Morpholines; Sequence Analysis, DNA; Terbinafine; Triazoles; Voriconazole | 2020 |
Novel Application of Pentabromobenzyl Column for Simultaneous Determination of Eight Antifungal Drugs Using High-performance Liquid Chromatography.
Topics: Antifungal Agents; Chromatography, High Pressure Liquid; Clotrimazole; Humans; Hydrocarbons, Brominated; Imidazoles; Ketoconazole; Liquid-Liquid Extraction; Molecular Structure; Thiophenes; Triazoles; Voriconazole | 2020 |
Comparison of in vitro antifungal activity of novel triazoles with available antifungal agents against dermatophyte species caused tinea pedis.
Topics: Antifungal Agents; Arthrodermataceae; Dermatomycoses; Fluconazole; Griseofulvin; Humans; Imidazoles; Itraconazole; Ketoconazole; Microbial Sensitivity Tests; Terbinafine; Tinea; Tinea Pedis; Triazoles; Trichophyton; Voriconazole | 2020 |
Differential Impacts of Azole Antifungal Drugs on the Pharmacokinetic Profiles of Dasatinib in Rats by LC-MS-MS.
Topics: Administration, Oral; Animals; Antifungal Agents; Area Under Curve; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dasatinib; Drug Interactions; Drug Monitoring; Humans; Itraconazole; Ketoconazole; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Models, Animal; Protein Kinase Inhibitors; Rats; Tandem Mass Spectrometry; Triazoles; Voriconazole | 2020 |
Effects of CYP3A inhibitors ketoconazole, voriconazole, and itraconazole on the pharmacokinetics of sunitinib and its main metabolite in rats.
Topics: Administration, Oral; Animals; Cytochrome P-450 CYP3A Inhibitors; Itraconazole; Ketoconazole; Male; Rats, Sprague-Dawley; Sunitinib; Voriconazole | 2021 |
In vitro activity of 23 antifungal drugs against 54 clinical and environmental Aspergillus oryzae isolates.
Topics: Amphotericin B; Anidulafungin; Antifungal Agents; Aspergillus oryzae; Clotrimazole; Econazole; Fluconazole; Griseofulvin; Humans; Itraconazole; Ketoconazole; Miconazole; Microbial Sensitivity Tests; Natamycin; Nystatin; Terbinafine; Tolnaftate; Voriconazole | 2022 |
Malassezia species: the need to establish epidemiological cutoff values.
Topics: Amphotericin B; Animals; Antifungal Agents; Fluconazole; Humans; Itraconazole; Ketoconazole; Malassezia; Microbial Sensitivity Tests; Voriconazole | 2022 |
Evaluation of the inhibitory effect of azoles on pharmacokinetics of lenvatinib in rats both in vivo and in vitro by UPLC-MS/MS.
Topics: Animals; Antifungal Agents; Azoles; Chromatography, Liquid; Humans; Ketoconazole; Molecular Docking Simulation; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry; Voriconazole | 2023 |