Compounds > ketoconazole

ketoconazole and ursodeoxycholic acid

ketoconazole has been researched along with ursodeoxycholic acid in 9 studies

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (22.22)18.2507
2000's1 (11.11)29.6817
2010's6 (66.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cvetkovic, M; Kim, RB; Leake, B; Nadeau, J; Roden, MM; Walubo, A; Wilkinson, GR1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Ekins, S; Williams, AJ; Xu, JJ1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Bouscarel, B; Cassidy, MM; Ceryak, S; Fromm, H1
Kagawa, Y; Kato, Y; Kurosawa, S; Misaka, S; Uchida, S; Yamada, S; Yoshida, A1

Reviews

1 review(s) available for ketoconazole and ursodeoxycholic acid

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Other Studies

8 other study(ies) available for ketoconazole and ursodeoxycholic acid

ArticleYear
Modulation by drugs of human hepatic sodium-dependent bile acid transporter (sodium taurocholate cotransporting polypeptide) activity.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 291, Issue:3

    Topics: Bile Acids and Salts; Biological Transport, Active; Carrier Proteins; Cells, Cultured; HeLa Cells; Humans; Kinetics; Liver; Nicotine; Organic Anion Transporters, Sodium-Dependent; Plasmids; RNA, Messenger; Salicylates; Symporters; Vaccinia virus; Valproic Acid

1999
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
Ursodeoxycholic acid increases low-density lipoprotein binding, uptake and degradation in isolated hamster hepatocytes.
    The Biochemical journal, 1991, Dec-15, Volume: 280 ( Pt 3)

    Topics: Animals; Cricetinae; Dose-Response Relationship, Drug; Ketoconazole; L-Lactate Dehydrogenase; Lipoproteins, LDL; Liver; Male; Receptors, LDL; Time Factors; Ursodeoxycholic Acid

1991
Evaluation of the pharmacokinetic interaction of midazolam with ursodeoxycholic acid, ketoconazole and dexamethasone by brain benzodiazepine receptor occupancy.
    The Journal of pharmacy and pharmacology, 2011, Volume: 63, Issue:1

    Topics: Administration, Oral; Animals; Brain; Cytochrome P-450 CYP3A; Dexamethasone; Drug Interactions; Enzyme Induction; Enzyme Inhibitors; GABA Modulators; Ketoconazole; Male; Midazolam; Protein Binding; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Time Factors; Ursodeoxycholic Acid

2011