Compounds > ketoconazole

ketoconazole and troleandomycin

ketoconazole has been researched along with troleandomycin in 50 studies

Research

Studies (50)

TimeframeStudies, this research(%)All Research%
pre-19902 (4.00)18.7374
1990's17 (34.00)18.2507
2000's21 (42.00)29.6817
2010's10 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Casciano, CN; Clement, RP; Johnson, WW; Wang, EJ1
Dantzig, AH; Ekins, S; Kim, RB; Lan, LB; Leake, BF; Schuetz, EG; Schuetz, JD; Shepard, RL; Wikel, JH; Winter, MA; Wrighton, SA; Yasuda, K1
Furuya, K; Lan, LB; Sanglard, D; Schuetz, EG; Schuetz, JD; Yasuda, K1
Davis, CD; Dworetzky, S; Fitzpatrick, WC; Harden, D; He, H; Knox, RJ; Newton, AE; Philip, T; Polson, C; Sinz, MW; Sivarao, DV; Sun, LQ; Tertyshnikova, S; Weaver, D; Wu, YJ; Yeola, S; Zoeckler, M1
Pratim Roy, P; Roy, K1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Ekins, S; Williams, AJ; Xu, JJ1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY1
Guzelian, PS; Hostetler, KA; Levin, W; Molowa, DT; Thomas, PE; Wrighton, SA1
Advenier, C; Naline, E; Pays, M; Sanceaume, M1
Burmaster, SD; Cheng, LK; Hook, RH; Leeson, GA; Ling, KH; Reith, MK1
Barra, Y; Maurel, P; Placidi, M; Rahmani, R; Sérée, E; Zhou, XJ; Zhou-Pan, XR1
Oster, G; Thompson, D1
Cayen, MN; Chen, KJ; Clement, RP; Huie, K; Snow, M; Yumibe, N1
Bader, A; Christians, U; Gonschior, AK; Hackbarth, I; Lampen, A; Sewing, KF; von Engelhardt, W1
Balani, SK; Chiba, M; Hensleigh, M; Lin, JH; Nishime, JA1
Hiroki, S; Shimada, T; Urano, T; Yamazaki, H1
Artursson, P; Dobson, GL; Guo, Z; Hidalgo, IJ; Raeissi, SD1
Ishizaki, T; Zhao, XJ1
Ishizaki, T; Kawashiro, T; Zhao, XJ1
Haaz, MC; Riché, C; Rivory, L; Robert, J; Vernillet, L1
Haaz, MC; Riché, C; Rivory, LP; Robert, J1
Aguilar, AJ; Grace, JM; Skanchy, DJ1
Baner, K; Benet, LZ; Christians, U; Deters, M; Hackbarth, I; Hallensleben, K; Jacobsen, W; Kirchner, G; Mancinelli, L; Sewing, KF1
Erickson, DA; Keirns, JJ; Levy, RH; Mather, G; Trager, WF1
Ashton, M; Svensson, US1
Arai, N; Fujimaki, Y; Inaba, T1
Obach, RS1
Gunnarsson, PO; Persson, R; Seidegård, J; Tuvesson, H; Wienkers, LC1
Cook, CS; Engel, LC; Fitzloff, JF; Zhang, L1
Liu, XQ; Qian, ZY; Ren, YL; Wang, GJ1
Boobis, AR; Edwards, RJ; Kappers, WA; Murray, S1
Baldwin, A; Huang, Z; Jounaidi, Y; Waxman, DJ1
Greenblatt, DJ; Harmatz, JS; Hesse, LM; Richert, C; von Moltke, LL; Weemhoff, JL1
Greenblatt, DJ; Perloff, MD; Von Moltke, LL1
Kohno, Y; Suzuki, A; Yamamoto, T1
Bell, NH; Gupta, RP; Halpert, JR; He, YA; Patrick, KS1
Dale, O; Kharasch, ED; Klees, TM; Sheffels, P1
Marks, B; Raucy, J; Trubetskoy, O; Yueh, MF; Zielinski, T1
Beulz-Riché, D; Filaquier, C; Grudé, P; Puozzo, C; Ratanasavanh, D; Riché, C; Sautel, F1
Davis, CL; Hashizume, T; Kalhorn, TF; Nelson, WL; Sakaki, T; Schuetz, EG; Shuhart, MC; Thummel, KE; Watkins, PB; Xu, Y1
Al-Shurbaji, A; Annas, A; Artursson, P; Lazorova, L; Svensson, JO; Yasar, U1
Liu, ZG; Mei, QB; Yang, TH; Yang, ZF; Zhou, SY1
Cao, YF; Fang, ZZ; Ge, GB; Hu, D; Huang, T; Huo, H; Li, J; Liu, HX; Sun, DX; Wang, YC; Yang, L; Yin, J; Zhang, YY1
Cui, SL; Deng, JT; Kong, WL; Li, H; Tian, XT; Wen, YY; Xie, L; Zhuang, XM1
Kubickova, B; Martinkova, M; Stiborova, M1
Jiang, H; Ma, L; Shen, Q; Tian, Y; Wang, L; Yu, L; Zeng, S; Zhou, H; Zhou, Q; Zuo, M1
Fukami, T; Iida, A; Nakajima, M; Sasaki, E; Tsuneyama, K; Yano, A; Yokoi, T1
Conzen, SD; Greene, GL; House, L; Isikbay, M; Mirkov, S; Ramirez, J; Ratain, MJ; Sachleben, JR; Seminerio, MJ; Singhal, H; Skor, M; Vander Griend, D1

Other Studies

50 other study(ies) available for ketoconazole and troleandomycin

ArticleYear
Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors.
    Biochemical and biophysical research communications, 2001, Nov-30, Volume: 289, Issue:2

    Topics: 3T3 Cells; Adrenergic Uptake Inhibitors; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Biological Transport, Active; Cell Line; Cell Separation; Cell Survival; Flow Cytometry; Fluorescent Dyes; Humans; Inhibitory Concentration 50; Mice; Protein Binding; Reserpine; Spectrometry, Fluorescence; Substrate Specificity; Time Factors

2001
Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein.
    Molecular pharmacology, 2002, Volume: 61, Issue:5

    Topics: Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Ergonovine; Fluoxetine; Humans; Models, Molecular; Oxytocics; Protein Conformation; Selective Serotonin Reuptake Inhibitors; Structure-Activity Relationship; Swine; Transfection; Vinblastine

2002
Interaction of cytochrome P450 3A inhibitors with P-glycoprotein.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 303, Issue:1

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Line; Cells, Cultured; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dihydroergocryptine; Drug Interactions; Enzyme Inhibitors; Fluconazole; Humans; Mice; Mice, Knockout; Microsomes, Liver; Oxidoreductases, N-Demethylating; Recombinant Proteins; Reserpine; Swine; Tissue Distribution; Transfection; Vinblastine

2002
Fluorine substitution can block CYP3A4 metabolism-dependent inhibition: identification of (S)-N-[1-(4-fluoro-3- morpholin-4-ylphenyl)ethyl]-3- (4-fluorophenyl)acrylamide as an orally bioavailable KCNQ2 opener devoid of CYP3A4 metabolism-dependent inhibiti
    Journal of medicinal chemistry, 2003, Aug-28, Volume: 46, Issue:18

    Topics: Administration, Oral; Animals; Biological Availability; Cell Line; Cinnamates; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Disease Models, Animal; Fluorine; Injections, Intravenous; Ion Channel Gating; KCNQ2 Potassium Channel; Male; Membrane Potentials; Migraine Disorders; Morpholines; Parietal Lobe; Patch-Clamp Techniques; Potassium Channels; Potassium Channels, Voltage-Gated; Rats; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship

2003
Comparative chemometric modeling of cytochrome 3A4 inhibitory activity of structurally diverse compounds using stepwise MLR, FA-MLR, PLS, GFA, G/PLS and ANN techniques.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:7

    Topics: Algorithms; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Enzyme Inhibitors; Factor Analysis, Statistical; Least-Squares Analysis; Linear Models; Models, Molecular; Neural Networks, Computer; Quantitative Structure-Activity Relationship; Reproducibility of Results

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding

2012
Coinduction of multiple hepatic cytochrome P-450 proteins and their mRNAs in rats treated with imidazole antimycotic agents.
    Molecular pharmacology, 1989, Volume: 35, Issue:3

    Topics: Animals; Clotrimazole; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Female; Imidazoles; Isoenzymes; Ketoconazole; Liver; Miconazole; Rats; Rats, Inbred Strains; RNA, Messenger; Troleandomycin

1989
Application of theophylline metabolite assays to the exploration of liver microsome oxidative function in man.
    Fundamental & clinical pharmacology, 1988, Volume: 2, Issue:4

    Topics: Adult; Biotransformation; Cimetidine; Humans; Ketoconazole; Male; Microsomes, Liver; Oxidation-Reduction; Spectrophotometry, Ultraviolet; Theophylline; Troleandomycin

1988
Metabolism of terfenadine associated with CYP3A(4) activity in human hepatic microsomes.
    Drug metabolism and disposition: the biological fate of chemicals, 1995, Volume: 23, Issue:6

    Topics: Alcohols; Biotransformation; Chromatography, High Pressure Liquid; Cloning, Molecular; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Hydroxylation; Isoenzymes; Ketoconazole; Kinetics; Microsomes, Liver; Mixed Function Oxygenases; Reagent Kits, Diagnostic; Terfenadine; Troleandomycin

1995
Involvement of human liver cytochrome P450 3A in vinblastine metabolism: drug interactions.
    Cancer research, 1993, Nov-01, Volume: 53, Issue:21

    Topics: Adolescent; Adult; Antibodies; Base Sequence; Binding, Competitive; Biotransformation; Blotting, Western; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Drug Interactions; Erythromycin; Female; Humans; Ketoconazole; Kinetics; Male; Microsomes, Liver; Middle Aged; Mixed Function Oxygenases; Molecular Sequence Data; Multigene Family; Oligodeoxyribonucleotides; RNA, Messenger; Troleandomycin; Vinblastine; Vindesine

1993
Use of terfenadine and contraindicated drugs.
    JAMA, 1996, May-01, Volume: 275, Issue:17

    Topics: Anti-Bacterial Agents; Antifungal Agents; Clarithromycin; Contraindications; Drug Interactions; Drug Utilization; Erythromycin; Histamine H1 Antagonists; Humans; Itraconazole; Ketoconazole; Pharmaceutical Services; Product Labeling; Retrospective Studies; Terfenadine; Troleandomycin

1996
Identification of human liver cytochrome P450 enzymes that metabolize the nonsedating antihistamine loratadine. Formation of descarboethoxyloratadine by CYP3A4 and CYP2D6.
    Biochemical pharmacology, 1996, Jan-26, Volume: 51, Issue:2

    Topics: Anti-Bacterial Agents; Antifungal Agents; Antimalarials; Binding Sites; Biotransformation; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Histamine H1 Antagonists; Humans; In Vitro Techniques; Ketoconazole; Loratadine; Microsomes, Liver; Mixed Function Oxygenases; Models, Molecular; Oxidation-Reduction; Piperidines; Pyridines; Quinidine; Recombinant Proteins; Substrate Specificity; Troleandomycin

1996
Metabolism of the macrolide immunosuppressant, tacrolimus, by the pig gut mucosa in the Ussing chamber.
    British journal of pharmacology, 1996, Volume: 117, Issue:8

    Topics: Animals; Anti-Bacterial Agents; Antifungal Agents; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Gastric Mucosa; Immunosuppressive Agents; Ketoconazole; Oxidoreductases, N-Demethylating; Swine; Tacrolimus; Troleandomycin; Vasodilator Agents; Verapamil

1996
Role of cytochrome P450 3A4 in human metabolism of MK-639, a potent human immunodeficiency virus protease inhibitor.
    Drug metabolism and disposition: the biological fate of chemicals, 1996, Volume: 24, Issue:3

    Topics: Anti-Bacterial Agents; Antifungal Agents; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; HIV Protease Inhibitors; Humans; Hydroxylation; Indinavir; Isoenzymes; Ketoconazole; Microsomes, Liver; Mixed Function Oxygenases; Troleandomycin

1996
Effects of erythromycin and roxithromycin on oxidation of testosterone and nifedipine catalyzed by CYP3A4 in human liver microsomes.
    The Journal of toxicological sciences, 1996, Volume: 21, Issue:4

    Topics: Animals; Anti-Bacterial Agents; Catalysis; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Erythromycin; Humans; Ketoconazole; Male; Microsomes, Liver; Mixed Function Oxygenases; Nifedipine; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Roxithromycin; Testosterone; Troleandomycin

1996
Comparison of CYP3A activities in a subclone of Caco-2 cells (TC7) and human intestine.
    Pharmaceutical research, 1997, Volume: 14, Issue:8

    Topics: Antibodies; Aryl Hydrocarbon Hydroxylases; Caco-2 Cells; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Humans; Hydroxylation; Intestinal Mucosa; Jejunum; Ketoconazole; Microsomes; Microsomes, Liver; Oxidation-Reduction; Oxidoreductases, N-Demethylating; Steroid Hydroxylases; Terfenadine; Troleandomycin

1997
Metabolic interactions of selected antimalarial and non-antimalarial drugs with the major pathway (3-hydroxylation) of quinine in human liver microsomes.
    British journal of clinical pharmacology, 1997, Volume: 44, Issue:5

    Topics: Anti-Infective Agents; Antimalarials; Chromatography; Cytochrome P-450 Enzyme System; Doxycycline; Drug Interactions; Erythromycin; Humans; Hydroxylation; Ketoconazole; Microsomes, Liver; Nifedipine; Omeprazole; Primaquine; Quinine; Tetracycline; Troleandomycin

1997
Mutual inhibition between quinine and etoposide by human liver microsomes. Evidence for cytochrome P4503A4 involvement in their major metabolic pathways.
    Drug metabolism and disposition: the biological fate of chemicals, 1998, Volume: 26, Issue:2

    Topics: Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Etoposide; Humans; Ketoconazole; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases, O-Demethylating; Quinidine; Quinine; Troleandomycin

1998
Metabolism of irinotecan (CPT-11) by human hepatic microsomes: participation of cytochrome P-450 3A and drug interactions.
    Cancer research, 1998, Feb-01, Volume: 58, Issue:3

    Topics: Antineoplastic Agents, Phytogenic; Aryl Hydrocarbon Hydroxylases; Biotransformation; Camptothecin; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Irinotecan; Ketoconazole; Microsomes, Liver; Molecular Structure; Oxidoreductases, N-Demethylating; Recombinant Proteins; Structure-Activity Relationship; Transfection; Troleandomycin

1998
Biosynthesis of an aminopiperidino metabolite of irinotecan [7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecine] by human hepatic microsomes.
    Drug metabolism and disposition: the biological fate of chemicals, 1998, Volume: 26, Issue:8

    Topics: Anti-Bacterial Agents; Antifungal Agents; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Biotransformation; Camptothecin; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Irinotecan; Isoenzymes; Ketoconazole; Kinetics; Microsomes, Liver; Troleandomycin

1998
Metabolism of artelinic acid to dihydroqinqhaosu by human liver cytochrome P4503A.
    Xenobiotica; the fate of foreign compounds in biological systems, 1999, Volume: 29, Issue:7

    Topics: Adult; Aged; Antifungal Agents; Antimalarials; Artemisinins; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Combinations; Drug Interactions; Drugs, Chinese Herbal; Enzyme Inhibitors; Female; Glycyrrhiza; Humans; Inactivation, Metabolic; Inhibitory Concentration 50; Isoenzymes; Ketoconazole; Liver; Male; Miconazole; Microsomes, Liver; Middle Aged; Oxidoreductases, N-Demethylating; Paeonia; Quinidine; Recombinant Proteins; Sesquiterpenes; Sulfaphenazole; Troleandomycin; Vasodilator Agents; Verapamil

1999
Small intestinal metabolism of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor lovastatin and comparison with pravastatin.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 291, Issue:1

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Intestine, Small; Ketoconazole; Lovastatin; Male; Microsomes, Liver; Oxidoreductases, N-Demethylating; Pravastatin; Swine; Troleandomycin

1999
Characterization of the in vitro biotransformation of the HIV-1 reverse transcriptase inhibitor nevirapine by human hepatic cytochromes P-450.
    Drug metabolism and disposition: the biological fate of chemicals, 1999, Volume: 27, Issue:12

    Topics: Antibodies; Biotransformation; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DNA, Complementary; Drug Interactions; HIV Reverse Transcriptase; Humans; In Vitro Techniques; Ketoconazole; Microsomes, Liver; Nevirapine; Phenotype; Recombinant Proteins; Reverse Transcriptase Inhibitors; Troleandomycin

1999
Identification of the human cytochrome P450 enzymes involved in the in vitro metabolism of artemisinin.
    British journal of clinical pharmacology, 1999, Volume: 48, Issue:4

    Topics: Antimalarials; Artemisinins; Aryl Hydrocarbon Hydroxylases; Cell Line; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; DNA, Complementary; Drug Interactions; Humans; Isoenzymes; Ketoconazole; Methoxsalen; Microsomes, Liver; Mixed Function Oxygenases; Orphenadrine; Oxidoreductases, N-Demethylating; Regression Analysis; Sesquiterpenes; Time Factors; Troleandomycin

1999
Identification of cytochromes P450 involved in human liver microsomal metabolism of ecabapide, a prokinetic agent.
    Xenobiotica; the fate of foreign compounds in biological systems, 1999, Volume: 29, Issue:12

    Topics: Anti-Ulcer Agents; Benzamides; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Inactivation, Metabolic; Isoenzymes; Ketoconazole; Miconazole; Microsomes, Liver; NADP; Substrate Specificity; Troleandomycin

1999
Metabolism of ezlopitant, a nonpeptidic substance P receptor antagonist, in liver microsomes: enzyme kinetics, cytochrome P450 isoform identity, and in vitro-in vivo correlation.
    Drug metabolism and disposition: the biological fate of chemicals, 2000, Volume: 28, Issue:9

    Topics: Animals; Benzylamines; Bridged Bicyclo Compounds, Heterocyclic; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dogs; Enzyme Inhibitors; Guinea Pigs; Haplorhini; Humans; Isoenzymes; Ketoconazole; Kinetics; Metabolic Clearance Rate; Microsomes, Liver; Neurokinin-1 Receptor Antagonists; Quinidine; Rats; Species Specificity; Sulfaphenazole; Tritium; Troleandomycin

2000
Identification of cytochrome P4503A as the major subfamily responsible for the metabolism of roquinimex in man.
    Xenobiotica; the fate of foreign compounds in biological systems, 2000, Volume: 30, Issue:9

    Topics: Antibodies; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DNA, Complementary; Enzyme Inhibitors; Female; Gene Expression; Humans; Hydroxylation; Hydroxyquinolines; Ketoconazole; Kinetics; Male; Microsomes, Liver; Mixed Function Oxygenases; Testosterone; Troleandomycin

2000
Species difference in stereoselective involvement of CYP3A in the mono-N-dealkylation of disopyramide.
    Xenobiotica; the fate of foreign compounds in biological systems, 2001, Volume: 31, Issue:2

    Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Disopyramide; Dogs; Enzyme Inhibitors; Humans; Inactivation, Metabolic; Ketoconazole; Kinetics; Microsomes, Liver; Mixed Function Oxygenases; Molecular Sequence Data; Oxidoreductases, N-Demethylating; Recombinant Proteins; Species Specificity; Troleandomycin

2001
Enzyme kinetics and inhibition of nimodipine metabolism in human liver microsomes.
    Acta pharmacologica Sinica, 2000, Volume: 21, Issue:8

    Topics: Calcium Channel Blockers; Humans; In Vitro Techniques; Ketoconazole; Microsomes, Liver; Nimodipine; Troleandomycin

2000
Diazinon is activated by CYP2C19 in human liver.
    Toxicology and applied pharmacology, 2001, Nov-15, Volume: 177, Issue:1

    Topics: Aryl Hydrocarbon Hydroxylases; Biotransformation; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Diazinon; Dose-Response Relationship, Drug; Humans; Insecticides; Ketoconazole; Liver; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Recombinant Proteins; Theophylline; Troleandomycin

2001
Identification of novel enzyme-prodrug combinations for use in cytochrome P450-based gene therapy for cancer.
    Archives of biochemistry and biophysics, 2003, Jan-01, Volume: 409, Issue:1

    Topics: Animals; Anti-Bacterial Agents; Antifungal Agents; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Hormonal; Coculture Techniques; Cyclophosphamide; Cytochrome P-450 Enzyme System; Dacarbazine; Dose-Response Relationship, Drug; Doxorubicin; Enzyme Activation; Female; Genetic Therapy; Ifosfamide; Inhibitory Concentration 50; Ketoconazole; Liver; Male; Microsomes, Liver; Models, Chemical; Neoplasms; Procarbazine; Prodrugs; Rats; Tamoxifen; Time Factors; Troleandomycin; Tumor Cells, Cultured

2003
Apparent mechanism-based inhibition of human CYP3A in-vitro by lopinavir.
    The Journal of pharmacy and pharmacology, 2003, Volume: 55, Issue:3

    Topics: Anti-Bacterial Agents; Antifungal Agents; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP3A; Enzyme Inhibitors; GABA Modulators; HIV Protease Inhibitors; Humans; Hydroxylation; In Vitro Techniques; Isoenzymes; Ketoconazole; Lopinavir; Microsomes, Liver; Oxidoreductases, N-Demethylating; Pyrimidinones; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Triazolam; Troleandomycin

2003
Differential metabolism of midazolam in mouse liver and intestine microsomes: a comparison of cytochrome P450 activity and expression.
    Xenobiotica; the fate of foreign compounds in biological systems, 2003, Volume: 33, Issue:4

    Topics: Algorithms; Animals; Anti-Anxiety Agents; Antibodies, Blocking; Biotransformation; Blotting, Western; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; In Vitro Techniques; Intestinal Mucosa; Isoenzymes; Ketoconazole; Kinetics; Mice; Mice, Inbred ICR; Microsomes; Microsomes, Liver; Midazolam; Organ Specificity; Ritonavir; Troleandomycin

2003
High-throughput screening for the assessment of time-dependent inhibitions of new drug candidates on recombinant CYP2D6 and CYP3A4 using a single concentration method.
    Xenobiotica; the fate of foreign compounds in biological systems, 2004, Volume: 34, Issue:1

    Topics: Amiodarone; Animals; Baculoviridae; Binding, Competitive; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diltiazem; Enzyme Inhibitors; Fluorescence; Humans; Inhibitory Concentration 50; Ketoconazole; Miconazole; Midazolam; Propafenone; Quinolines; Recombinant Proteins; Troleandomycin; Verapamil

2004
CYP3A4 is a vitamin D-24- and 25-hydroxylase: analysis of structure function by site-directed mutagenesis.
    The Journal of clinical endocrinology and metabolism, 2005, Volume: 90, Issue:2

    Topics: Animals; Baculoviridae; Cholestanetriol 26-Monooxygenase; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Insecta; Isoniazid; Ketoconazole; Kinetics; Microsomes, Liver; Mutagenesis, Site-Directed; Recombinant Proteins; Steroid Hydroxylases; Transfection; Troleandomycin; Vitamin D; Vitamin D3 24-Hydroxylase

2005
Metabolism of alfentanil by cytochrome p4503a (cyp3a) enzymes.
    Drug metabolism and disposition: the biological fate of chemicals, 2005, Volume: 33, Issue:3

    Topics: Alfentanil; Analgesics, Opioid; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP3A; Cytochromes b5; Enzyme Inhibitors; Humans; In Vitro Techniques; Isoenzymes; Ketoconazole; Kinetics; Microsomes; Oxidoreductases, N-Demethylating; Troleandomycin

2005
A simultaneous assessment of CYP3A4 metabolism and induction in the DPX-2 cell line.
    The AAPS journal, 2005, Mar-04, Volume: 7, Issue:1

    Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Chromans; Clotrimazole; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Dimethyl Sulfoxide; Enhancer Elements, Genetic; Enzyme Induction; Genes, Reporter; Genes, Synthetic; Humans; Ketoconazole; Liver Neoplasms; Lovastatin; Luciferases; Mifepristone; Neoplasm Proteins; Nifedipine; Omeprazole; Paclitaxel; Phenytoin; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Recombinant Fusion Proteins; Rifampin; Thiazolidinediones; Transcription, Genetic; Troglitazone; Troleandomycin

2005
Characterization of human cytochrome P450 isoenzymes involved in the metabolism of vinorelbine.
    Fundamental & clinical pharmacology, 2005, Volume: 19, Issue:5

    Topics: Adult; Aged; Animals; Antibodies; Antineoplastic Agents, Phytogenic; Blotting, Western; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Female; Humans; Isoenzymes; Ketoconazole; Male; Microsomes, Liver; Middle Aged; Time Factors; Tritium; Troleandomycin; Vinblastine; Vinorelbine

2005
Intestinal and hepatic CYP3A4 catalyze hydroxylation of 1alpha,25-dihydroxyvitamin D(3): implications for drug-induced osteomalacia.
    Molecular pharmacology, 2006, Volume: 69, Issue:1

    Topics: Base Sequence; Caco-2 Cells; Calbindins; Calcitriol; Catalysis; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; DNA Primers; Gas Chromatography-Mass Spectrometry; Humans; Hydroxylation; Intestine, Small; Ketoconazole; Kinetics; Liver; Midazolam; Osteomalacia; Recombinant Proteins; S100 Calcium Binding Protein G; Troleandomycin

2006
Ketobemidone is a substrate for cytochrome P4502C9 and 3A4, but not for P-glycoprotein.
    Xenobiotica; the fate of foreign compounds in biological systems, 2005, Volume: 35, Issue:8

    Topics: ATP Binding Cassette Transporter, Subfamily B; Biological Transport; Caco-2 Cells; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; Isonipecotic Acids; Ketoconazole; Kinetics; Meperidine; Microsomes, Liver; Mutagenesis, Site-Directed; Phenols; Substrate Specificity; Sulfaphenazole; Troleandomycin; Verapamil

2005
[Metabolic kinetics of MN9202 in Beagle dog liver microsomes].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2005, Volume: 40, Issue:11

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Calcium Channel Blockers; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A Inhibitors; Dihydropyridines; Dogs; Ketoconazole; Microsomes, Liver; Mixed Function Oxygenases; Nitrobenzenes; Tranylcypromine; Troleandomycin

2005
CYP3A catalyses schizandrin biotransformation in human, minipig and rat liver microsomes.
    Xenobiotica; the fate of foreign compounds in biological systems, 2010, Volume: 40, Issue:1

    Topics: Animals; Catalysis; Chromatography, High Pressure Liquid; Cyclooctanes; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Humans; Ketoconazole; Lignans; Mass Spectrometry; Metabolic Networks and Pathways; Microsomes, Liver; Polycyclic Compounds; Rats; Swine; Swine, Miniature; Troleandomycin

2010
[Metabolism of 3-cyanomethyl-4-methyl-DCK, a new anti-HIV candidate, in human intestinal microsomes].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2010, Volume: 45, Issue:9

    Topics: Anti-HIV Agents; Biological Availability; Bridged Bicyclo Compounds, Heterocyclic; Coumarins; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Humans; Intestinal Mucosa; Ketoconazole; Metabolic Clearance Rate; Microsomes; Ritonavir; Troleandomycin

2010
Effects of cytochrome P450 inhibitors on peroxidase activity.
    Neuro endocrinology letters, 2012, Volume: 33 Suppl 3

    Topics: Benzoflavones; Cytochrome P-450 Enzyme Inhibitors; Disulfiram; Ditiocarb; Ellipticines; Enzyme Activation; Enzyme Inhibitors; Horseradish Peroxidase; Humans; Ketoconazole; Metyrapone; Piperonyl Butoxide; Proadifen; Quinidine; Structure-Activity Relationship; Substrate Specificity; Sulfaphenazole; Triazoles; Troleandomycin

2012
Demethylation of neferine in human liver microsomes and formation of quinone methide metabolites mediated by CYP3A4 accentuates its cytotoxicity.
    Chemico-biological interactions, 2014, Dec-05, Volume: 224

    Topics: Acetylcysteine; Animals; Antineoplastic Agents; Benzylisoquinolines; Buthionine Sulfoximine; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dogs; Glutathione; Hep G2 Cells; Humans; Indolequinones; Ketoconazole; Kinetics; Madin Darby Canine Kidney Cells; Microsomes, Liver; Troleandomycin

2014
Carbamazepine-Induced Liver Injury Requires CYP3A-Mediated Metabolism and Glutathione Depletion in Rats.
    Drug metabolism and disposition: the biological fate of chemicals, 2015, Volume: 43, Issue:7

    Topics: Alanine Transaminase; Animals; Anti-Bacterial Agents; Antifungal Agents; Buthionine Sulfoximine; Carbamazepine; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP3A; Enzyme Induction; Enzyme Inhibitors; Glutathione; Hydroxylation; Ketoconazole; Liver; Male; Microsomes, Liver; Rats; Rats, Inbred F344; Troleandomycin

2015
Metabolism of megestrol acetate in vitro and the role of oxidative metabolites.
    Xenobiotica; the fate of foreign compounds in biological systems, 2018, Volume: 48, Issue:10

    Topics: Cell Line, Tumor; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Glucuronides; Humans; Ketoconazole; Kinetics; Megestrol Acetate; Metabolome; Microsomes, Liver; Oxidation-Reduction; Prostate-Specific Antigen; Proton Magnetic Resonance Spectroscopy; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; Substrate Specificity; Troleandomycin

2018