ketoconazole and triazolam

ketoconazole has been researched along with triazolam in 21 studies

Research

Studies (21)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	7 (33.33)	18.2507
2000's	9 (42.86)	29.6817
2010's	5 (23.81)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Artursson, P; Bergström, CA; Draheim, R; Holmén, AG; Wassvik, CM	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Greenblatt, DJ; Harmatz, JS; Harrel, LM; Shader, RI; Tobias, S; von Moltke, LL; Wright, CE	1
Neuvonen, PJ; Olkkola, KT; Varhe, A	1
Cotreau-Bibbo, MM; Duan, SX; Greenblatt, DJ; Harmatz, JS; Harrel, LM; Pritchard, GA; Shader, RI; von Moltke, LL; Wright, CE	1
Fahey, JM; Grassi, JM; Greenblatt, DJ; Moltke, LL; Pratt, JS; Pritchard, GA; Shader, RI	1
Kitada, M; Kiuchi, M; Nakamura, H; Nakasa, H; Ohmori, S; Ono, S; Tsutsui, M	1
Corbett, K; Counihan, M; Ehrenberg, BL; Greenblatt, DJ; Harmatz, JS; Harrel, LM; Shader, RI; Tobias, S; von Moltke, LL; Wright, CE	1
Balian, JD; Flockhart, DA; Yuan, R	1
Court, MH; Greenblatt, DJ; Kotegawa, T; Perloff, MD; Shader, RI; von Moltke, LL	1
Duan, SX; Durol, AL; Greenblatt, DJ; von Moltke, LL	1
Greenblatt, DJ; Harmatz, JS; Hesse, LM; Richert, C; von Moltke, LL; Weemhoff, JL	1
Greenblatt, DJ; Patki, KC; Von Moltke, LL	1
Granda, BW; Grassi, JM; Greenblatt, DJ; Perloff, MD; Vishnuvardhan, D; von Moltke, LL	1
Greenblatt, DJ; Von Moltke, LL; Warrington, JS	1
Beijnen, JH; Rooswinkel, RW; Schinkel, AH; Sparidans, RW; van Herwaarden, AE; van Waterschoot, RA	1
Court, MH; Duan, SX; Greenblatt, DJ; Harmatz, JS; Parent, SJ; Venkatakrishnan, K; von Moltke, LL; Zhao, Y	1
Cancalon, PF; Chen, C; Gmitter, FG; Greenblatt, DJ; Hanley, MJ; Harmatz, JS; Zhao, Y	1

Reviews

2 review(s) available for ketoconazole and triazolam

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Pharmacokinetic and pharmacodynamic consequences of metabolism-based drug interactions with alprazolam, midazolam, and triazolam. Journal of clinical pharmacology, 1999, Volume: 39, Issue:11 Topics: Alprazolam; Anti-Anxiety Agents; Data Collection; Drug Interactions; Enzyme Induction; Enzyme Inhibitors; Humans; Itraconazole; Ketoconazole; Midazolam; Triazolam	1999

Trials

4 trial(s) available for ketoconazole and triazolam

Article	Year
Interaction of triazolam and ketoconazole. Lancet (London, England), 1995, Jan-21, Volume: 345, Issue:8943 Topics: Cross-Over Studies; Double-Blind Method; Humans; Ketoconazole; Triazolam	1995
Oral triazolam is potentially hazardous to patients receiving systemic antimycotics ketoconazole or itraconazole. Clinical pharmacology and therapeutics, 1994, Volume: 56, Issue:6 Pt 1 Topics: Administration, Oral; Adult; Analysis of Variance; Cytochrome P-450 Enzyme System; Double-Blind Method; Drug Synergism; Female; Half-Life; Humans; Itraconazole; Ketoconazole; Male; Reference Values; Triazolam	1994
Triazolam biotransformation by human liver microsomes in vitro: effects of metabolic inhibitors and clinical confirmation of a predicted interaction with ketoconazole. The Journal of pharmacology and experimental therapeutics, 1996, Volume: 276, Issue:2 Topics: Adult; Aged; Animals; Antifungal Agents; Biotransformation; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Humans; Hypnotics and Sedatives; Ketoconazole; Male; Mice; Microsomes, Liver; Middle Aged; Triazolam	1996
Ketoconazole inhibition of triazolam and alprazolam clearance: differential kinetic and dynamic consequences. Clinical pharmacology and therapeutics, 1998, Volume: 64, Issue:3 Topics: Administration, Oral; Adult; Alprazolam; Antifungal Agents; Area Under Curve; Cross-Over Studies; Double-Blind Method; Electroencephalography; Humans; Hypnotics and Sedatives; Ketoconazole; Male; Reference Values; Time Factors; Triazolam	1998

Other Studies

15 other study(ies) available for ketoconazole and triazolam

Article	Year
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Molecular characteristics for solid-state limited solubility. Journal of medicinal chemistry, 2008, May-22, Volume: 51, Issue:10 Topics: Chemical Phenomena; Chemistry, Physical; Molecular Structure; Multivariate Analysis; Pharmaceutical Preparations; Regression Analysis; Solubility	2008
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Effects of ketoconazole on triazolam pharmacokinetics, pharmacodynamics and benzodiazepine receptor binding in mice. The Journal of pharmacology and experimental therapeutics, 1998, Volume: 285, Issue:1 Topics: Animals; Antifungal Agents; Binding Sites; Biotransformation; Flunitrazepam; GABA Modulators; Ketoconazole; Male; Mice; Receptors, GABA-A; Triazolam	1998
Prediction of drug-drug interactions of zonisamide metabolism in humans from in vitro data. European journal of clinical pharmacology, 1998, Volume: 54, Issue:2 Topics: Anticonvulsants; Cyclosporine; Cytochrome P-450 Enzyme System; Dihydroergotamine; Drug Interactions; Humans; In Vitro Techniques; Isoxazoles; Itraconazole; Ketoconazole; Metabolic Clearance Rate; Miconazole; Triazolam; Zonisamide	1998
Midazolam and triazolam biotransformation in mouse and human liver microsomes: relative contribution of CYP3A and CYP2C isoforms. The Journal of pharmacology and experimental therapeutics, 2000, Volume: 292, Issue:2 Topics: Animals; Antibodies; Aryl Hydrocarbon Hydroxylases; Biotransformation; Blotting, Western; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Humans; Immunochemistry; In Vitro Techniques; Inhibitory Concentration 50; Ketoconazole; Mice; Microsomes, Liver; Midazolam; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Protein Isoforms; Species Specificity; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Triazolam	2000
Potent mechanism-based inhibition of human CYP3A in vitro by amprenavir and ritonavir: comparison with ketoconazole. European journal of clinical pharmacology, 2000, Volume: 56, Issue:3 Topics: Aryl Hydrocarbon Hydroxylases; Carbamates; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Furans; Humans; Hydroxylation; Ketoconazole; Oxidoreductases, N-Demethylating; Ritonavir; Sulfonamides; Triazolam	2000
Apparent mechanism-based inhibition of human CYP3A in-vitro by lopinavir. The Journal of pharmacy and pharmacology, 2003, Volume: 55, Issue:3 Topics: Anti-Bacterial Agents; Antifungal Agents; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP3A; Enzyme Inhibitors; GABA Modulators; HIV Protease Inhibitors; Humans; Hydroxylation; In Vitro Techniques; Isoenzymes; Ketoconazole; Lopinavir; Microsomes, Liver; Oxidoreductases, N-Demethylating; Pyrimidinones; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Triazolam; Troleandomycin	2003
In vitro metabolism of midazolam, triazolam, nifedipine, and testosterone by human liver microsomes and recombinant cytochromes p450: role of cyp3a4 and cyp3a5. Drug metabolism and disposition: the biological fate of chemicals, 2003, Volume: 31, Issue:7 Topics: Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Humans; Ketoconazole; Microsomes, Liver; Midazolam; Nifedipine; Recombinant Proteins; Testosterone; Triazolam	2003
Interaction of triazolam and ketoconazole in P-glycoprotein-deficient mice. Drug metabolism and disposition: the biological fate of chemicals, 2004, Volume: 32, Issue:8 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Dose-Response Relationship, Drug; Drug Interactions; Humans; Ketoconazole; Male; Mice; Mice, Knockout; Triazolam	2004
Role of CYP3A enzymes in the biotransformation of triazolam in rat liver. Xenobiotica; the fate of foreign compounds in biological systems, 2004, Volume: 34, Issue:5 Topics: Adult; Animals; Aryl Hydrocarbon Hydroxylases; Biotransformation; Cytochrome P-450 CYP3A; Enzyme Inhibitors; GABA-A Receptor Agonists; Humans; Hydroxylation; In Vitro Techniques; Isoenzymes; Ketoconazole; Kinetics; Male; Microsomes, Liver; Oxidoreductases, N-Demethylating; Rats; Rats, Inbred F344; Recombinant Proteins; Triazolam	2004
Inhibition and stimulation of intestinal and hepatic CYP3A activity: studies in humanized CYP3A4 transgenic mice using triazolam. Drug metabolism and disposition: the biological fate of chemicals, 2009, Volume: 37, Issue:12 Topics: Administration, Oral; Animals; Antineoplastic Agents; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Activators; Enzyme Inhibitors; Gefitinib; Humans; Hydroxylation; Intestines; Ketoconazole; Liver; Male; Mice; Mice, Knockout; Mice, Transgenic; Microsomes; Quinazolines; Species Specificity; Substrate Specificity; Triazolam	2009
Mechanism of cytochrome P450-3A inhibition by ketoconazole. The Journal of pharmacy and pharmacology, 2011, Volume: 63, Issue:2 Topics: Adult; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Humans; Inhibitory Concentration 50; Ketoconazole; Male; Microsomes, Liver; Midazolam; Middle Aged; Nifedipine; Testosterone; Triazolam; Young Adult	2011
Mechanism-based inhibition of human cytochrome P450-3A activity by grapefruit hybrids having low furanocoumarin content. Xenobiotica; the fate of foreign compounds in biological systems, 2012, Volume: 42, Issue:12 Topics: Beverages; Citrus paradisi; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Furocoumarins; Humans; Hybridization, Genetic; Hydroxylation; Inhibitory Concentration 50; Ketoconazole; Triazolam	2012