ketoconazole and tamoxifen

ketoconazole has been researched along with tamoxifen in 43 studies

Research

Studies (43)

Timeframe	Studies, this research(%)	All Research%
pre-1990	4 (9.30)	18.7374
1990's	4 (9.30)	18.2507
2000's	10 (23.26)	29.6817
2010's	23 (53.49)	24.3611
2020's	2 (4.65)	2.80

Authors

Authors	Studies
Jones, LH; Nadanaciva, S; Rana, P; Will, Y	1
Bloomer, WD; Papadopoulou, MV; Rosenzweig, HS	1
Barouch-Bentov, R; Brannan, JM; De Jonghe, S; Dye, JM; Einav, S; Herdewijn, P; O'Brien, CM; Prugar, LI; Pu, SY; Rozenski, J; Schor, S; Wouters, R	1
Gao, F; Huang, G; Xiao, J	1
Lyubina, AP; Mironov, VF; Pashirova, TN; Sapunova, AS; Shaihutdinova, ZM; Tatarinov, DA; Terekhova, NV; Voloshina, AD; Zakharova, LY	1
Dubrovskyi, O; Dye, K; Gutgesell, LM; Huang, F; Li, Y; Ratia, K; Shen, Z; Thatcher, GRJ; Tonetti, DA; Xiong, R; Zhao, H; Zhao, J	1
Casciano, CN; Clement, RP; Johnson, WW; Wang, EJ	2
Pajeva, IK; Wiese, M	1
Bacsó, Z; Cianfriglia, M; Fenyvesi, F; Goda, K; Kappelmayer, J; Lustyik, G; Nagy, H; Szabó, G; Szilasi, M	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Bilter, GK; Dias, J; Huang, Z; Keon, BH; Lamerdin, J; MacDonald, ML; Michnick, SW; Minami, T; Owens, S; Shang, Z; Westwick, JK; Yu, H	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ghosh, I; Manoharlal, R; Prakash, O; Prasad, R; Puri, N; Sharma, M	1
Glen, RC; Lowe, R; Mitchell, JB	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Sen, S; Sinha, N	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Freiwald, S; Jiang, Y; Jones, JP; Kaspera, R; Katayama, J; Lee, CA; Smith, E; Totah, RA; Walker, GS	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Cho, H; Elkamhawy, A; Heo, JC; Kim, HY; Kim, KH; Lee, CO; Nam, DH; Pae, AN; Park, WK; Roh, EJ; Seol, HJ; Viswanath, AN; Yang, H	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Arnstein, HR; Cannon, M; Halliwell, B; Smith, C; Wiseman, H	1
Albert, J; Berry, CC; Fay, W; Geller, J; Liu, J	1
Waxman, J	1
Albert, J; Berry, CC; Fay, W; Geller, J; Liu, J; Weis, P	1
Boublil, JL; Cavaglione, G; Kather, R; Namer, M	1
Lennard, MS; Martin, IJ; Tucker, GT; Williams, ML	1
Peterson, ME; Quesenberry, KE; Rosenthal, KL	1
Cripps, MC; Dahrouge, S; Davies, RA; Goel, R; Huan, S; Prosser, A; Soltys, K; Stewart, DJ; Tomiak, E; Yau, J	1
Baldwin, A; Huang, Z; Jounaidi, Y; Waxman, DJ	1
Boustani, M; Chiang, C; Flockhart, D; Han, X; Karnik, S; Li, L; Liu, L; Philips, S; Quinney, SK; Rocha, LM; Subhadarshini, A; Wang, Z; Wu, HY	1
Lammintausta, R; Lehtinen, T; Pelkonen, O; Scheinin, M; Tolonen, A; Turpeinen, M; Uusitalo, J; Vuorinen, J	1
Li, AP; Loretz, C; Utkarsh, D	1
Honda, H; Ito, Y; Kawamoto, T; Morita, O	1

Reviews

3 review(s) available for ketoconazole and tamoxifen

Article	Year
Current scenario of tetrazole hybrids for antibacterial activity. European journal of medicinal chemistry, 2019, Dec-15, Volume: 184 Topics: Anti-Bacterial Agents; Bacteria; Dose-Response Relationship, Drug; Microbial Sensitivity Tests; Molecular Structure; Structure-Activity Relationship; Tetrazoles	2019
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Hormonal aspects of prostatic cancer: a review. Journal of the Royal Society of Medicine, 1985, Volume: 78, Issue:2 Topics: Adrenalectomy; Castration; Cyproterone; Diethylstilbestrol; Hormones; Humans; Hypophysectomy; Ketoconazole; Male; Middle Aged; Pituitary Hormone-Releasing Hormones; Prostatic Neoplasms; Receptors, Cell Surface; Tamoxifen; Testosterone	1985

Trials

1 trial(s) available for ketoconazole and tamoxifen

Article	Year
Effects of cytochrome P450 inhibitors and inducers on the metabolism and pharmacokinetics of ospemifene. Biopharmaceutics & drug disposition, 2013, Volume: 34, Issue:7 Topics: Aged; Aged, 80 and over; Cross-Over Studies; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Estrogen Receptor Modulators; Female; Humans; Ketoconazole; Microsomes, Liver; Middle Aged; Postmenopause; Rifampin; Tamoxifen	2013

Article

Year

Effects of cytochrome P450 inhibitors and inducers on the metabolism and pharmacokinetics of ospemifene.

Biopharmaceutics & drug disposition, 2013, Volume: 34, Issue:7

Topics: Aged; Aged, 80 and over; Cross-Over Studies; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Estrogen Receptor Modulators; Female; Humans; Ketoconazole; Microsomes, Liver; Middle Aged; Postmenopause; Rifampin; Tamoxifen

2013

Other Studies

39 other study(ies) available for ketoconazole and tamoxifen

Article	Year
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16 Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone	2016
The antitubercular activity of various nitro(triazole/imidazole)-based compounds. Bioorganic & medicinal chemistry, 2017, 11-01, Volume: 25, Issue:21 Topics: Animals; Antitubercular Agents; Cell Line; Chlorocebus aethiops; Dose-Response Relationship, Drug; Humans; Imidazoles; Macrophages; Mice; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Nitro Compounds; Structure-Activity Relationship; Triazoles	2017
Optimization of Isothiazolo[4,3- b]pyridine-Based Inhibitors of Cyclin G Associated Kinase (GAK) with Broad-Spectrum Antiviral Activity. Journal of medicinal chemistry, 2018, Jul-26, Volume: 61, Issue:14 Topics: Antiviral Agents; Cell Line; Humans; Intracellular Signaling Peptides and Proteins; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyridines; Structure-Activity Relationship; Thiazoles	2018
Design and synthesis of amphiphilic 2-hydroxybenzylphosphonium salts with antimicrobial and antitumor dual action. Bioorganic & medicinal chemistry letters, 2020, 07-01, Volume: 30, Issue:13 Topics: Anti-Bacterial Agents; Antifungal Agents; Antineoplastic Agents; Arthrodermataceae; Bacillus cereus; Candida albicans; Cell Line, Tumor; Drug Design; Drug Screening Assays, Antitumor; Humans; Microbial Sensitivity Tests; Organophosphorus Compounds; Staphylococcus aureus	2020
Novel Pyrrolopyridone Bromodomain and Extra-Terminal Motif (BET) Inhibitors Effective in Endocrine-Resistant ER+ Breast Cancer with Acquired Resistance to Fulvestrant and Palbociclib. Journal of medicinal chemistry, 2020, 07-09, Volume: 63, Issue:13 Topics: Animals; Breast Neoplasms; Drug Resistance, Neoplasm; Fulvestrant; Humans; MCF-7 Cells; Mice; Models, Molecular; Piperazines; Protein Domains; Pyridines; Pyridones; Receptors, Estrogen; Tissue Distribution; Transcription Factors; Xenograft Model Antitumor Assays	2020
Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors. Biochemical and biophysical research communications, 2001, Nov-30, Volume: 289, Issue:2 Topics: 3T3 Cells; Adrenergic Uptake Inhibitors; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Biological Transport, Active; Cell Line; Cell Separation; Cell Survival; Flow Cytometry; Fluorescent Dyes; Humans; Inhibitory Concentration 50; Mice; Protein Binding; Reserpine; Spectrometry, Fluorescence; Substrate Specificity; Time Factors	2001
Pharmacophore model of drugs involved in P-glycoprotein multidrug resistance: explanation of structural variety (hypothesis). Journal of medicinal chemistry, 2002, Dec-19, Volume: 45, Issue:26 Topics: Adenosine Triphosphatases; Algorithms; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Binding, Competitive; Caco-2 Cells; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fluoresceins; Humans; Ligands; Models, Molecular; Molecular Structure; Quantitative Structure-Activity Relationship; Radioligand Assay; Rhodamine 123; Stereoisomerism; Verapamil; Vinblastine	2002
Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: evidence for contingent unequal binding sites. Pharmaceutical research, 2003, Volume: 20, Issue:4 Topics: ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Binding Sites; Biological Transport, Active; Biomarkers; Cells, Cultured; Drug Interactions; Fluorescent Dyes; Humans	2003
Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies. Biochemical and biophysical research communications, 2004, Mar-19, Volume: 315, Issue:4 Topics: Adenosine Triphosphatases; Animals; Anti-Bacterial Agents; Antibodies, Monoclonal; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding, Competitive; Calcium Channel Blockers; Cyclosporine; Detergents; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Fluoresceins; Humans; Ivermectin; Mice; NIH 3T3 Cells; Substrate Specificity	2004
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Identifying off-target effects and hidden phenotypes of drugs in human cells. Nature chemical biology, 2006, Volume: 2, Issue:6 Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship	2006
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans. European journal of medicinal chemistry, 2010, Volume: 45, Issue:11 Topics: Candida albicans; Membrane Transport Proteins; Saccharomyces cerevisiae; Structure-Activity Relationship; Substrate Specificity	2010
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model. European journal of medicinal chemistry, 2011, Volume: 46, Issue:2 Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship	2011
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Identifying a selective substrate and inhibitor pair for the evaluation of CYP2J2 activity. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:5 Topics: Amiodarone; Astemizole; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Danazol; Drug Discovery; Drug Interactions; Enzyme Inhibitors; Humans; Hydroxylation; In Vitro Techniques; Methylation; Microsomes, Liver; Models, Biological; Molecular Structure; Substrate Specificity; Tandem Mass Spectrometry; Terfenadine	2012
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Discovery of potent and selective cytotoxic activity of new quinazoline-ureas against TMZ-resistant glioblastoma multiforme (GBM). European journal of medicinal chemistry, 2015, Oct-20, Volume: 103 Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Dose-Response Relationship, Drug; Drug Discovery; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Glioblastoma; Humans; Models, Molecular; Molecular Conformation; Quinazolines; Structure-Activity Relationship; Temozolomide; Urea	2015
The antioxidant action of ketoconazole and related azoles: comparison with tamoxifen and cholesterol. Chemico-biological interactions, 1991, Volume: 79, Issue:2 Topics: Animals; Antioxidants; Ascorbic Acid; Brain; Cattle; Cholesterol; Ergosterol; Estrogen Antagonists; Ferric Compounds; Iron; Ketoconazole; Lipid Peroxidation; Liposomes; Male; Microsomes, Liver; Phospholipids; Rats; Stilbenes; Tamoxifen	1991
Effect of antiandrogen and/or antiestrogen blockade on human prostate epithelial and stromal cell protein synthesis. Journal of steroid biochemistry, 1986, Volume: 25, Issue:5B Topics: Dihydrotestosterone; Epithelium; Humans; Ketoconazole; Kinetics; Male; Megestrol; Megestrol Acetate; Prostate; Prostatic Hyperplasia; Protein Biosynthesis; Tamoxifen	1986
Relationship between human prostatic epithelial cell protein synthesis and tissue dihydrotestosterone level. Clinical endocrinology, 1987, Volume: 26, Issue:2 Topics: Aged; Dihydrotestosterone; Epithelium; Humans; Ketoconazole; Male; Megestrol; Megestrol Acetate; Prostate; Protein Biosynthesis; Tamoxifen	1987
[Cancer of the prostate: new hormone therapies]. Bulletin du cancer, 1986, Volume: 73, Issue:1 Topics: Androgen Antagonists; Cyproterone; Flutamide; Humans; Ketoconazole; Male; Medroxyprogesterone; Megestrol; Neoplasms, Hormone-Dependent; Progestins; Prostatic Neoplasms; Tamoxifen	1986
Interindividual variation in the isomerization of 4-hydroxytamoxifen by human liver microsomes: involvement of cytochromes P450. Carcinogenesis, 1994, Volume: 15, Issue:12 Topics: Adult; Biotransformation; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Resistance; Female; Genetic Variation; Humans; Isomerism; Ketoconazole; Male; Microsomes, Liver; Middle Aged; NADP; Proadifen; Tamoxifen	1994
Questions about assays used for estradiol 1-17 beta. Journal of the American Veterinary Medical Association, 1994, Apr-01, Volume: 204, Issue:7 Topics: Adrenal Cortex Neoplasms; Animals; Estradiol; Female; Ferrets; Ketoconazole; Male; Radioimmunoassay; Tamoxifen	1994
Pilot study of multiple chemotherapy resistance modulators plus epirubicin in the treatment of resistant malignancies. Cancer chemotherapy and pharmacology, 1997, Volume: 41, Issue:1 Topics: Adjuvants, Pharmaceutic; Administration, Oral; Adult; Aged; Antibiotics, Antineoplastic; Antifungal Agents; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Antitrichomonal Agents; Cyclosporine; Dipyridamole; Drug Resistance, Neoplasm; Epirubicin; Female; Humans; Immunosuppressive Agents; Ketoconazole; Male; Metronidazole; Middle Aged; Neoplasms; Pilot Projects; Tamoxifen; Vasodilator Agents	1997
Identification of novel enzyme-prodrug combinations for use in cytochrome P450-based gene therapy for cancer. Archives of biochemistry and biophysics, 2003, Jan-01, Volume: 409, Issue:1 Topics: Animals; Anti-Bacterial Agents; Antifungal Agents; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Hormonal; Coculture Techniques; Cyclophosphamide; Cytochrome P-450 Enzyme System; Dacarbazine; Dose-Response Relationship, Drug; Doxorubicin; Enzyme Activation; Female; Genetic Therapy; Ifosfamide; Inhibitory Concentration 50; Ketoconazole; Liver; Male; Microsomes, Liver; Models, Chemical; Neoplasms; Procarbazine; Prodrugs; Rats; Tamoxifen; Time Factors; Troleandomycin; Tumor Cells, Cultured	2003
An integrated pharmacokinetics ontology and corpus for text mining. BMC bioinformatics, 2013, Feb-01, Volume: 14 Topics: Cytochrome P-450 Enzyme System; Data Mining; Databases, Factual; Drug Interactions; Ketoconazole; Midazolam; Pharmacokinetics; Tamoxifen	2013
In vitro evaluation of hepatotoxic drugs in human hepatocytes from multiple donors: Identification of P450 activity as a potential risk factor for drug-induced liver injuries. Chemico-biological interactions, 2016, Aug-05, Volume: 255 Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Antifungal Agents; Cells, Cultured; Chemical and Drug Induced Liver Injury; Child; Cyclophosphamide; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Evaluation, Preclinical; Estrogen Antagonists; Female; Hepatocytes; Humans; Immunosuppressive Agents; Ketoconazole; Liver; Male; Middle Aged; Protein Isoforms; Tamoxifen; Young Adult	2016
Mechanism-based risk assessment strategy for drug-induced cholestasis using the transcriptional benchmark dose derived by toxicogenomics. The Journal of toxicological sciences, 2017, Volume: 42, Issue:4 Topics: Administration, Oral; Animals; Chlorpromazine; Cholestasis; Cholesterol; Cyclosporine; Diclofenac; Dose-Response Relationship, Drug; Flutamide; Gene Expression; Humans; Imipramine; Inflammation; Ketoconazole; Liver; Methyltestosterone; Oxidative Stress; Rats; Risk Assessment; Sulindac; Tamoxifen; Toxicogenetics	2017