ketoconazole and tacrolimus

ketoconazole has been researched along with tacrolimus in 29 studies

Research

Studies (29)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	4 (13.79)	18.2507
2000's	14 (48.28)	29.6817
2010's	9 (31.03)	24.3611
2020's	2 (6.90)	2.80

Authors

Authors	Studies
Jones, LH; Nadanaciva, S; Rana, P; Will, Y	1
Delabio, LC; Dutra, JP; Hembecker, M; Kita, DH; Moure, VR; Pereira, GDS; Scheiffer, G; Valdameri, G; Zattoni, IF	1
Cannon, RD; Holmes, AR; Lamping, E; Nakamura, K; Niimi, K; Niimi, M; Ranchod, A; Tyndall, JD	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Chen, X; Lin, X; Skolnik, S; Wang, J	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Adibzadeh, M; Friccius, H; Pawelec, G; Pohla, H; Schenk, A; Siegels-Hübenthal, P	1
Bader, A; Christians, U; Gonschior, AK; Hackbarth, I; Lampen, A; Sewing, KF; von Engelhardt, W	1
Bekersky, I; Benet, LZ; Dressler, D; Floren, LC; Hebert, MF; Lee, JW; Mekki, Q; Roberts, JP	1
Andres, A; Carreño, A; Cubas, A; Delgado, M; Dominguez-Gil, B; Herrero, JC; Latorre, A; Manzanares, C; Morales, E; Morales, JM; Moreno, M	1
Bauer, BE; Chen, XJ; Clark-Walker, GD; Kuchler, K	1
Alloway, RR; Gaber, AO; Johnson, JA; Tuteja, S	1
Amae, S; Endo, N; Hayashi, Y; Ishii, T; Nio, M; Nishi, K; Ohi, R; Sano, N; Wada, M	1
Carbajal, H; Rodríguez-Montalvo, C; Soltero, L; Valdés, A	1
Haehner, T; Müller-Enoch, D; Refaie, MO	1
Badr, Ael-S; Bakr, MA; Donia, AF; el-Dahshan, KF; Sobh, MA	2
Abdel-Maboud, M; Barakat, N; El-Agroudy, A; El-Shair, MA; Ghoneim, MA; Hawas, S; Sabry, A	1
Barakat, N; El-Agroudy, A; El-Shahat, FB; Hawas, S; Sabry, A; Sheashaa, H	1
Akhlaghi, F; Gohh, RY; Harmon, M; Patel, CG	1
Iwasaki, K	1
Akar, A; Arca, E; Koc, E; Kose, O	1
Aggarwal, PK; Chandel, N; Jha, V; Kohli, KK; Minz, M; Sakhuja, V	1
Chin-Hong, PV; Hickey, MD; Quan, DJ; Roberts, JP	1
Abbas, M; Dablouk, N; El-Magzoub, AR; Elamin, S; Mahmoud, F	1
Gupta, AK; Versteeg, SG	1
Chen, C; Cui, Y; Li, M; Ma, L; Wu, S; Xue, T; Yang, T; Zhou, Y	1

Reviews

5 review(s) available for ketoconazole and tacrolimus

Article	Year
Targeting breast cancer resistance protein (BCRP/ABCG2): Functional inhibitors and expression modulators. European journal of medicinal chemistry, 2022, Jul-05, Volume: 237 Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; Breast Neoplasms; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Humans; Neoplasm Proteins; Neoplastic Stem Cells	2022
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Metabolism of tacrolimus (FK506) and recent topics in clinical pharmacokinetics. Drug metabolism and pharmacokinetics, 2007, Volume: 22, Issue:5 Topics: Biotransformation; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Drug Monitoring; Enzyme Inhibitors; Humans; Immunoenzyme Techniques; Immunosuppressive Agents; Ketoconazole; Molecular Structure; Nifedipine; Polymorphism, Single Nucleotide; Tacrolimus	2007
Topical Treatment of Facial Seborrheic Dermatitis: A Systematic Review. American journal of clinical dermatology, 2017, Volume: 18, Issue:2 Topics: Administration, Cutaneous; Anti-Inflammatory Agents; Antifungal Agents; Calcineurin Inhibitors; Ciclopirox; Dermatitis, Seborrheic; Dermatologic Agents; Desonide; Facial Dermatoses; Humans; Ketoconazole; Malassezia; Mometasone Furoate; Plant Preparations; Practice Guidelines as Topic; Pyridones; Quality of Life; Randomized Controlled Trials as Topic; Tacrolimus; Treatment Outcome; Vitamins	2017
Efficacy and safety of ketoconazole combined with calmodulin inhibitor in solid organ transplantation: A systematic review and meta-analysis. Journal of clinical pharmacy and therapeutics, 2020, Volume: 45, Issue:1 Topics: Calcineurin Inhibitors; Cyclosporine; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Ketoconazole; Organ Transplantation; Randomized Controlled Trials as Topic; Tacrolimus	2020

Trials

5 trial(s) available for ketoconazole and tacrolimus

Article	Year
Co-administration of ketoconazole to tacrolimus-treated kidney transplant recipients: a prospective randomized study. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2004, Volume: 19, Issue:6 Topics: Adolescent; Adult; Antifungal Agents; Creatinine; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Ketoconazole; Kidney Transplantation; Male; Middle Aged; Prospective Studies; Tacrolimus	2004
Ketoconazole-tacrolimus coadministration in kidney transplant recipients: two-year results of a prospective randomized study. American journal of nephrology, 2006, Volume: 26, Issue:3 Topics: Adolescent; Adult; Drug Combinations; Female; Graft Rejection; Humans; Immunosuppressive Agents; Ketoconazole; Kidney Transplantation; Male; Middle Aged; Tacrolimus; Treatment Outcome	2006
Concentrations of mycophenolic acid and glucuronide metabolites under concomitant therapy with cyclosporine or tacrolimus. Therapeutic drug monitoring, 2007, Volume: 29, Issue:1 Topics: Administration, Oral; Aged; Animals; Antibiotics, Antineoplastic; Area Under Curve; Cyclosporine; Diabetes Mellitus; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Glucuronides; Humans; Immunosuppressive Agents; Ketoconazole; Kidney Transplantation; Male; Middle Aged; Mycophenolic Acid; Prednisone; Rats; Rats, Sprague-Dawley; Tacrolimus	2007
An open, randomized, prospective, comparative study of topical pimecrolimus 1% cream and topical ketoconazole 2% cream in the treatment of seborrheic dermatitis. The Journal of dermatological treatment, 2009, Volume: 20, Issue:1 Topics: Adult; Chi-Square Distribution; Dermatitis, Seborrheic; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Ketoconazole; Male; Middle Aged; Ointments; Patient Satisfaction; Probability; Prospective Studies; Reference Values; Risk Assessment; Severity of Illness Index; Tacrolimus; Treatment Outcome; Turkey; Young Adult	2009
CYP3A51/3 genotype influences the blood concentration of tacrolimus in response to metabolic inhibition by ketoconazole. Pharmacogenetics and genomics, 2009, Volume: 19, Issue:6 Topics: Adult; Antifungal Agents; Cytochrome P-450 CYP3A; Female; Genotype; Humans; Immunosuppressive Agents; Ketoconazole; Male; Metabolic Clearance Rate; Polymorphism, Single Nucleotide; Tacrolimus	2009

Other Studies

19 other study(ies) available for ketoconazole and tacrolimus

Article	Year
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16 Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone	2016
Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:2 Topics: Amino Acid Sequence; Animals; Antifungal Agents; ATP-Binding Cassette Transporters; Azoles; Blotting, Northern; Blotting, Southern; Candida; Candidiasis; Cell Membrane; Chromosomes, Fungal; Drug Resistance, Fungal; Endoplasmic Reticulum; Humans; Phenotype; Plasmids; Reverse Transcriptase Polymerase Chain Reaction; Saccharomyces cerevisiae	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:2 Topics: Adenosine; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Chromatography, Liquid; Dibenzocycloheptenes; Diketopiperazines; Drug Discovery; Heterocyclic Compounds, 4 or More Rings; Humans; Intestinal Absorption; Mass Spectrometry; Models, Biological; Neoplasm Proteins; Pharmaceutical Preparations; Predictive Value of Tests; Propionates; Quinolines; Substrate Specificity	2011
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
The effects of the antifungal azoles itraconazole, fluconazole, ketoconazole and miconazole on cytokine gene expression in human lymphoid cells. International journal of immunopharmacology, 1992, Volume: 14, Issue:5 Topics: Antifungal Agents; Cells, Cultured; Cyclosporine; Cytokines; Fluconazole; Gene Expression; Humans; Itraconazole; Ketoconazole; Lymphocytes; Miconazole; Tacrolimus	1992
Metabolism of the macrolide immunosuppressant, tacrolimus, by the pig gut mucosa in the Ussing chamber. British journal of pharmacology, 1996, Volume: 117, Issue:8 Topics: Animals; Anti-Bacterial Agents; Antifungal Agents; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Gastric Mucosa; Immunosuppressive Agents; Ketoconazole; Oxidoreductases, N-Demethylating; Swine; Tacrolimus; Troleandomycin; Vasodilator Agents; Verapamil	1996
Tacrolimus oral bioavailability doubles with coadministration of ketoconazole. Clinical pharmacology and therapeutics, 1997, Volume: 62, Issue:1 Topics: Administration, Oral; Adult; Antifungal Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Female; Humans; Immunosuppressive Agents; Ketoconazole; Male; Mixed Function Oxygenases; Tacrolimus	1997
Clinical management of tacrolimus drug interactions in renal transplant patients. Transplantation proceedings, 1999, Volume: 31, Issue:6 Topics: Adult; Aged; Antifungal Agents; Candidiasis; Drug Interactions; Erythromycin; Female; Humans; Immunosuppressive Agents; Ketoconazole; Kidney Transplantation; Male; Phenytoin; Postoperative Complications; Rifampin; Tacrolimus	1999
Positive and negative control of multidrug resistance by the Sit4 protein phosphatase in Kluyveromyces lactis. The Journal of biological chemistry, 2000, May-19, Volume: 275, Issue:20 Topics: 4-Nitroquinoline-1-oxide; Antifungal Agents; Antimycin A; Drug Resistance, Multiple; Econazole; Genetic Complementation Test; Genotype; Ketoconazole; Kluyveromyces; Molecular Sequence Data; Oligomycins; Paromomycin; Phosphoprotein Phosphatases; Protein Phosphatase 2; Restriction Mapping; Saccharomyces cerevisiae Proteins; Sorbic Acid; Tacrolimus	2000
The effect of gut metabolism on tacrolimus bioavailability in renal transplant recipients. Transplantation, 2001, May-15, Volume: 71, Issue:9 Topics: Adult; Biological Availability; Female; Gastric Mucosa; Humans; Ketoconazole; Kidney Transplantation; Male; Middle Aged; Tacrolimus	2001
Oral FK 506 blood levels are elevated in pig short bowel model: further investigations with co-administration of an intestinal CYP3A4 inhibitor. Transplantation proceedings, 2002, Volume: 34, Issue:3 Topics: Administration, Oral; Anastomosis, Surgical; Animals; Area Under Curve; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Disease Models, Animal; Enzyme Inhibitors; Ileum; Immunosuppressive Agents; Intestinal Absorption; Intestinal Mucosa; Jejunum; Ketoconazole; Metabolic Clearance Rate; Mixed Function Oxygenases; Short Bowel Syndrome; Swine; Tacrolimus	2002
Coadministration of tacrolimus and ketoconazole in renal transplant recipients: cost analysis and review of metabolic effects. Transplantation proceedings, 2003, Volume: 35, Issue:4 Topics: Adolescent; Adult; Aged; Antifungal Agents; Cadaver; Costs and Cost Analysis; Demography; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Ketoconazole; Kidney Transplantation; Living Donors; Mexico; Middle Aged; Tacrolimus; Time Factors; Tissue Donors	2003
Drug-drug interactions evaluated by a highly active reconstituted native human cytochrome P4503A4 and human NADPH-cytochrome P450 reductase system. Arzneimittel-Forschung, 2004, Volume: 54, Issue:1 Topics: Antifungal Agents; Antimalarials; Catalysis; Chromatography, High Pressure Liquid; Cimetidine; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Electrophoresis, Polyacrylamide Gel; Estrogen Antagonists; Ethinyl Estradiol; Flavanones; Hormone Antagonists; Humans; Immunosuppressive Agents; In Vitro Techniques; Ketoconazole; Microsomes, Liver; Mifepristone; NADPH-Ferrihemoprotein Reductase; Phospholipids; Quinidine; Quinine; Tacrolimus	2004
Co-administration of ketoconazole and tacrolimus therapy: a transplanted rat model. International urology and nephrology, 2005, Volume: 37, Issue:3 Topics: Animals; Antifungal Agents; Area Under Curve; Creatinine; Drug Therapy, Combination; Immunosuppressive Agents; Ketoconazole; Kidney Transplantation; Male; Rats; Rats, Sprague-Dawley; Tacrolimus; Transaminases; Transplantation, Homologous	2005
Co-administration of ketoconazole and tacrolimus therapy: a transplanted rat model. International urology and nephrology, 2006, Volume: 38, Issue:3-4 Topics: Animals; Immunosuppressive Agents; Ketoconazole; Male; Rats; Rats, Sprague-Dawley; Tacrolimus	2006
Use of rifabutin for the treatment of a latent tuberculosis infection in a patient after solid organ transplantation. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2013, Volume: 19, Issue:4 Topics: Adolescent; Antibiotics, Antitubercular; Drug Interactions; Drug Monitoring; Drug Substitution; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Ketoconazole; Kidney Transplantation; Latent Tuberculosis; Liver Transplantation; Long QT Syndrome; Male; Rifabutin; Rifampin; Tacrolimus; Treatment Outcome	2013
Co-administration of ketoconazole and tacrolimus to kidney transplant recipients: cost minimization and potential metabolic benefits. Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 2014, Volume: 25, Issue:4 Topics: Adolescent; Adult; Antifungal Agents; Biomarkers; Cost Savings; Cost-Benefit Analysis; Drug Costs; Drug Monitoring; Female; Glomerular Filtration Rate; Humans; Immunosuppressive Agents; Ketoconazole; Kidney; Kidney Transplantation; Male; Middle Aged; Tacrolimus; Time Factors; Treatment Outcome; Uric Acid; Young Adult	2014