ketoconazole and pyrimidinones

ketoconazole has been researched along with pyrimidinones in 5 studies

Research

Studies (5)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (80.00)	29.6817
2010's	1 (20.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Greenblatt, DJ; Harmatz, JS; Hesse, LM; Richert, C; von Moltke, LL; Weemhoff, JL	1
Back, DJ; Boffito, M; Bonora, S; Dal Conte, I; Di Perri, G; Hoggard, PG; Khoo, S; Sales, P; Sinicco, A	1
Gottesdiener, KM; Kari, PP; Marbury, T; Miller, JL; Mistry, GC; Rodrigues, AD; Simpson, RC; Wagner, JA; Winchell, GA	1
Cho, JY; Jang, IJ; Kim, BH; Kim, JW; Kim, TE; Shin, KH; Shin, SG; Yi, S; Yoon, SH; Yu, KS	1
Chen, Y; Hickman, D; Hsieh, F; Shou, M; Skiles, GL	1

Trials

2 trial(s) available for ketoconazole and pyrimidinones

Article	Year
The effect of ketoconazole on the pharmacokinetics of a selective alpha 1A-adrenoceptor antagonist. Journal of clinical pharmacology, 2005, Volume: 45, Issue:6 Topics: Administration, Oral; Adrenergic alpha-1 Receptor Antagonists; Adult; Area Under Curve; Carbon Radioisotopes; Coumarins; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Fomepizole; Half-Life; Humans; Ketoconazole; Male; Microsomes, Liver; Pyrazoles; Pyrimidinones; Quinidine; Receptors, Adrenergic, alpha-1; Sulfaphenazole; Theophylline	2005
The effects of ketoconazole and rifampicin on the pharmacokinetics of mirodenafil in healthy Korean male volunteers: an open-label, one-sequence, three-period, three-treatment crossover study. Clinical therapeutics, 2009, Volume: 31, Issue:12 Topics: Adult; Asian People; Biological Availability; Biotransformation; Chromatography, Liquid; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Enzyme Induction; Enzyme Inhibitors; Humans; Ketoconazole; Korea; Male; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Pyrimidinones; Rifampin; Sulfonamides; Tandem Mass Spectrometry; Young Adult	2009

Article

Year

The effect of ketoconazole on the pharmacokinetics of a selective alpha 1A-adrenoceptor antagonist.

Journal of clinical pharmacology, 2005, Volume: 45, Issue:6

Topics: Administration, Oral; Adrenergic alpha-1 Receptor Antagonists; Adult; Area Under Curve; Carbon Radioisotopes; Coumarins; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Fomepizole; Half-Life; Humans; Ketoconazole; Male; Microsomes, Liver; Pyrazoles; Pyrimidinones; Quinidine; Receptors, Adrenergic, alpha-1; Sulfaphenazole; Theophylline

2005

The effects of ketoconazole and rifampicin on the pharmacokinetics of mirodenafil in healthy Korean male volunteers: an open-label, one-sequence, three-period, three-treatment crossover study.

Clinical therapeutics, 2009, Volume: 31, Issue:12

Topics: Adult; Asian People; Biological Availability; Biotransformation; Chromatography, Liquid; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Enzyme Induction; Enzyme Inhibitors; Humans; Ketoconazole; Korea; Male; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Pyrimidinones; Rifampin; Sulfonamides; Tandem Mass Spectrometry; Young Adult

2009

Other Studies

3 other study(ies) available for ketoconazole and pyrimidinones

Article	Year
Apparent mechanism-based inhibition of human CYP3A in-vitro by lopinavir. The Journal of pharmacy and pharmacology, 2003, Volume: 55, Issue:3 Topics: Anti-Bacterial Agents; Antifungal Agents; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP3A; Enzyme Inhibitors; GABA Modulators; HIV Protease Inhibitors; Humans; Hydroxylation; In Vitro Techniques; Isoenzymes; Ketoconazole; Lopinavir; Microsomes, Liver; Oxidoreductases, N-Demethylating; Pyrimidinones; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Triazolam; Troleandomycin	2003
Ketoconazole and lopinavir/ritonavir coadministration: boosting beyond boosting. AIDS research and human retroviruses, 2003, Volume: 19, Issue:10 Topics: Antifungal Agents; Drug Combinations; HIV Protease Inhibitors; HIV-1; Humans; Ketoconazole; Pyrimidinones; Ritonavir	2003
A novel biotransformation of alkyl aminopyrrolidine to aminopiperidine ring by human CYP3A. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:9 Topics: Biotransformation; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Humans; Hydroxylation; Ketoconazole; Magnetic Resonance Spectroscopy; Mass Spectrometry; Microsomes, Liver; Piperidines; Pyrimidinones; Pyrrolidines; Semicarbazides	2011