ketoconazole has been researched along with proadifen in 18 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (38.89) | 18.2507 |
| 2000's | 6 (33.33) | 29.6817 |
| 2010's | 5 (27.78) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Berger, ML; Hahner, S; Hammerschmidt, F; Peric-Simov, B; Schirbel, A; Zolle, IM | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Clark, JE; Harder, DR; Kauser, K; Ma, YH; Masters, BS; Ortiz de Montellano, PR; Roman, RJ | 1 |
| Kersting, D; Kersting, U; Spring, KR | 1 |
| Gustafsson, JA; Hamberg, M; Mode, A; Tollet, P | 1 |
| Grevel, J; Kahan, BD; Napoli, KL; Serino, F; Strobel, HW | 2 |
| Lennard, MS; Martin, IJ; Tucker, GT; Williams, ML | 1 |
| Bagnasco, SM; Handler, JS; Montrose, MH | 1 |
| Bruce, JI; Elliott, AC | 1 |
| Hurh, E; Kim, S; Kim, Y; Lee, A; Lee, E; Lee, M | 1 |
| Fujimoto, N; Kitamura, S; Kohno, Y; Ohta, S; Sanoh, S; Sugihara, K | 1 |
| Ishihara, Y; Shiba, D; Shimamoto, N | 1 |
| Kim, DK; Kim, YK; Kim, YW; Sheen, YY | 1 |
| Ishihara, Y; Ishii, S; Onishi, Y; Sakai, Y; Shimamoto, N; Yamamura, N | 1 |
| Greenhaw, J; Salminen, WF; Shi, Q; Yang, X | 1 |
| Kubickova, B; Martinkova, M; Stiborova, M | 1 |
| Greenhaw, J; Salminen, WF; Shi, Q | 1 |
18 other study(ies) available for ketoconazole and proadifen
| Article | Year |
|---|---|
New selective inhibitors of steroid 11beta-hydroxylation in the adrenal cortex. Synthesis and structure-activity relationship of potent etomidate analogues.
Topics: Adrenal Cortex; Animals; Binding Sites; Etomidate; Humans; Hydroxylation; Iodine Radioisotopes; Kinetics; Male; Molecular Structure; Rats; Rats, Wistar; Stereoisomerism; Steroid 11-beta-Hydroxylase; Structure-Activity Relationship | 2008 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Inhibitors of cytochrome P-450 attenuate the myogenic response of dog renal arcuate arteries.
Topics: Animals; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Dogs; Fatty Acids, Monounsaturated; Fatty Acids, Unsaturated; Hydrazines; Indomethacin; Ketoconazole; Kinetics; Muscle, Smooth, Vascular; Phospholipases A; Phospholipases A2; Phosphorylcholine; Proadifen; Renal Artery; Triazoles | 1991 |
Ketoconazole activates Cl- conductance and blocks Cl- and fluid absorption by cultured cystic fibrosis (CFPAC-1) cells.
Topics: Absorption; Cell Line; Cell Membrane; Chloride Channels; Chlorides; Colforsin; Cyclic AMP; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Epithelium; Humans; Hydrogen-Ion Concentration; Indomethacin; Ion Channels; Ketoconazole; Masoprocol; Membrane Potentials; Membrane Proteins; Proadifen; Thionucleotides; Transfection | 1993 |
Growth hormone signaling leading to CYP2C12 gene expression in rat hepatocytes involves phospholipase A2.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonic Acid; Aryl Hydrocarbon Hydroxylases; Benzoquinones; Calcimycin; Calcium-Calmodulin-Dependent Protein Kinases; Cytochrome P-450 Enzyme System; Diglycerides; Enzyme Activation; Gene Expression Regulation; Growth Hormone; Insulin-Like Growth Factor I; Ketoconazole; Lactams, Macrocyclic; Liver; Phospholipases A; Phospholipases A2; Phospholipids; Phosphorylation; Proadifen; Protein-Tyrosine Kinases; Quinacrine; Quinones; Rats; Rats, Sprague-Dawley; Rifabutin; RNA, Messenger; Signal Transduction; Steroid Hydroxylases; Verapamil | 1995 |
Oxygen radical formation by the cytochrome P450 system as a cellular mechanism for cyclosporine toxicity.
Topics: Aminopyrine; Animals; Chloramphenicol; Cyclosporine; Cytochrome P-450 Enzyme System; Enzyme Induction; Free Radical Scavengers; Ketoconazole; Kinetics; Lipid Peroxidation; Male; Microsomes, Liver; NADP; Phenobarbital; Proadifen; Rats; Rats, Sprague-Dawley | 1994 |
Interindividual variation in the isomerization of 4-hydroxytamoxifen by human liver microsomes: involvement of cytochromes P450.
Topics: Adult; Biotransformation; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Resistance; Female; Genetic Variation; Humans; Isomerism; Ketoconazole; Male; Microsomes, Liver; Middle Aged; NADP; Proadifen; Tamoxifen | 1994 |
Generation of oxygen free radicals during the metabolism of cyclosporine A: a cause-effect relationship with metabolism inhibition.
Topics: Aminopyrine; Animals; Carbon Tetrachloride; Catalase; Chloramphenicol; Cyclosporine; Cytochrome P-450 Enzyme System; Erythromycin; Free Radicals; Ketoconazole; Lipid Peroxidation; Male; Proadifen; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Superoxide Dismutase | 1993 |
Role of calcium in organic osmolyte efflux when MDCK cells are shifted from hypertonic to isotonic medium.
Topics: Animals; Betaine; Calcium; Cell Line; Cell Membrane; Culture Media; Dogs; Egtazic Acid; Hypertonic Solutions; Inositol; Ketoconazole; Kidney; Kinetics; Osmolar Concentration; Proadifen; Time Factors | 1993 |
Pharmacological evaluation of the role of cytochrome P450 in intracellular calcium signalling in rat pancreatic acinar cells.
Topics: Animals; Calcium Signaling; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Fatty Acids, Unsaturated; Imidazoles; Indoles; Ketoconazole; Male; Pancreas; Proadifen; Rats; Rats, Sprague-Dawley; Sincalide; Thapsigargin | 2000 |
Effects of enzyme inducers or inhibitors on the pharmacokinetics of intravenous parathion in rats.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Blotting, Western; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Drug Interactions; Enzyme Induction; Enzyme Inhibitors; Insecticides; Isoenzymes; Isoniazid; Ketoconazole; Male; Methylcholanthrene; Microsomes, Liver; Paraoxon; Parathion; Phenobarbital; Proadifen; Rats; Rats, Sprague-Dawley; Tissue Distribution | 2000 |
Metabolism of the alpha,beta-unsaturated ketones, chalcone and trans-4-phenyl-3-buten-2-one, by rat liver microsomes and estrogenic activity of the metabolites.
Topics: Animals; Biotransformation; Butanones; Cell Line, Tumor; Chalcone; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Estrogens; Gene Expression Regulation; Genes, Reporter; Humans; In Vitro Techniques; Isoenzymes; Ketoconazole; Liver; Luciferases; Male; Microsomes, Liver; Proadifen; Rats; Rats, Sprague-Dawley; Response Elements; Transfection | 2005 |
Enhancement of DMNQ-induced hepatocyte toxicity by cytochrome P450 inhibition.
Topics: Animals; Antioxidants; Benzoquinones; Catecholamines; Cell Survival; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Glutathione Disulfide; Hepatocytes; Imidazolines; Iron Chelating Agents; Ketoconazole; L-Lactate Dehydrogenase; Lipid Peroxidation; Male; Metyrapone; Molecular Structure; NADP; Naphthoquinones; Oxidative Stress; Proadifen; Rats; Rats, Wistar; Superoxides; Thiobarbituric Acid Reactive Substances | 2006 |
Identification of human cytochrome P450 enzymes involved in the metabolism of IN-1130, a novel activin receptor-like kinase-5 (ALK5) inhibitor.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dogs; Haplorhini; Humans; Imidazoles; In Vitro Techniques; Ketoconazole; Mice; Microsomes, Liver; Mixed Function Oxygenases; Oxygenases; Proadifen; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Quinoxalines; Rats; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Species Specificity | 2008 |
Crucial role of cytochrome P450 in hepatotoxicity induced by 2,3-dimethoxy-1,4-naphthoquinone in rats.
Topics: alpha-Tocopherol; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Glutathione; Ketoconazole; Lipid Peroxidation; Liver; Male; Naphthoquinones; Oxidation-Reduction; Oxidative Stress; Proadifen; Rats; Rats, Wistar; Substrate Cycling | 2011 |
Hepatic cytochrome P450s attenuate the cytotoxicity induced by leflunomide and its active metabolite A77 1726 in primary cultured rat hepatocytes.
Topics: Aniline Compounds; Animals; Benzoflavones; Biomarkers; Cell Survival; Cells, Cultured; Crotonates; Cytochrome P-450 Enzyme System; Hepatocytes; Hydroxybutyrates; Inactivation, Metabolic; Isoxazoles; Ketoconazole; Leflunomide; Liver; Male; Nitriles; Primary Cell Culture; Proadifen; Rats; Rats, Sprague-Dawley; Ticlopidine; Toluidines; Triazoles | 2011 |
Effects of cytochrome P450 inhibitors on peroxidase activity.
Topics: Benzoflavones; Cytochrome P-450 Enzyme Inhibitors; Disulfiram; Ditiocarb; Ellipticines; Enzyme Activation; Enzyme Inhibitors; Horseradish Peroxidase; Humans; Ketoconazole; Metyrapone; Piperonyl Butoxide; Proadifen; Quinidine; Structure-Activity Relationship; Substrate Specificity; Sulfaphenazole; Triazoles; Troleandomycin | 2012 |
Inhibition of cytochrome P450s enhances (+)-usnic acid cytotoxicity in primary cultured rat hepatocytes.
Topics: Animals; Benzoflavones; Benzofurans; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dietary Supplements; Enzyme Inhibitors; Hepatocytes; Ketoconazole; Liver; Male; Mitochondria; Proadifen; Rats; Rats, Sprague-Dawley; Ticlopidine | 2014 |