ketoconazole has been researched along with pregnenolone in 14 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (35.71) | 18.7374 |
| 1990's | 3 (21.43) | 18.2507 |
| 2000's | 1 (7.14) | 29.6817 |
| 2010's | 3 (21.43) | 24.3611 |
| 2020's | 2 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Ekins, S; Harwood, HJ; Hoover, DJ; Lawton, MP; Mankowski, DC; Treadway, JL | 1 |
| Bélanger, A; Roy, R | 1 |
| Barr, I; Diamant, YZ; Gal, M; Lior, O; Orly, J; Tadmor, O | 1 |
| Bähr, V; Eckhoff, C; Oelkers, W | 1 |
| Ayub, M; Stitch, SR | 1 |
| Belanger, A; Caron, S; Labrie, F; Lacoste, D; St-Arnaud, R | 1 |
| Contreras, P; Ravanal, M; Serón-Ferré, M | 1 |
| Ikeda, M; Katagiri, M; Koshida, H; Miyamori, I; Nagai, K; Suhara, K; Takeda, R | 1 |
| Estabrook, RW; Mason, JI; Swart, AC; Swart, P; Waterman, MR | 1 |
| Arlt, W; de Herder, WW; de Jong, FH; Feelders, RA; Hofland, J; Hofland, LJ; Steenbergen, J; Taylor, AE; van der Pas, R; van Koetsveld, PM | 1 |
| Hiramatsu, Y; Masuyama, H; Nakamura, K; Nobumoto, E | 1 |
| Fujii, Y; Kouchi, M; Matsumoto, I; Miyawaki, I; Tochitani, T; Yamashita, A | 1 |
| Chapman, JG; Guengerich, FP; McCarty, KD; Tateishi, Y | 1 |
| Cheung, G; Lin, YC; Papadopoulos, V; Porter, E | 1 |
14 other study(ies) available for ketoconazole and pregnenolone
| Article | Year |
|---|---|
Three-dimensional quantitative structure-activity relationship analysis of human CYP51 inhibitors.
Topics: Amides; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Humans; Indoles; Models, Molecular; Oxidoreductases; Quantitative Structure-Activity Relationship; Sterol 14-Demethylase | 2007 |
Elevated levels of endogenous pregnenolone fatty acid esters in follicular fluid high density lipoproteins support progesterone synthesis in porcine granulosa cells.
Topics: Animals; Cells, Cultured; Cholesterol Esters; Cholesterol Side-Chain Cleavage Enzyme; Female; Granulosa Cells; Humans; Ketoconazole; Kinetics; Lipoproteins, HDL; Ovarian Follicle; Pregnenolone; Progesterone; Swine | 1992 |
Effect of ketoconazole on steroidogenic human granulosa-luteal cells in culture.
Topics: Aromatase Inhibitors; Cells, Cultured; Cholesterol Side-Chain Cleavage Enzyme; Chorionic Gonadotropin; Estradiol; Female; Granulosa Cells; Humans; Ketoconazole; Luteal Cells; Pregnenolone; Progesterone; Testosterone | 1991 |
Effects of two oral antimycotics, ketoconazole and fluconazole, upon steroidogenesis in rat adrenal cells in vitro.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Antifungal Agents; Cells, Cultured; Dose-Response Relationship, Drug; Fluconazole; Ketoconazole; Male; Pregnenolone; Rats; Rats, Inbred Strains; Steroids; Triazoles | 1988 |
Effect of ketoconazole on placental aromatase, 3 beta-hydroxysteroid dehydrogenase-isomerase and 17 beta-hydroxysteroid dehydrogenase.
Topics: 17-Hydroxysteroid Dehydrogenases; 3-Hydroxysteroid Dehydrogenases; Aromatase Inhibitors; Estradiol; Female; Humans; Isomerases; Ketoconazole; Microsomes; Multienzyme Complexes; Placenta; Pregnancy; Pregnenolone; Progesterone Reductase; Steroid Isomerases | 1986 |
The rise in testicular androgens during the first days of treatment with an LHRH agonist in the dog can be blocked by aminoglutethimide or ketoconazole.
Topics: Aldehyde-Lyases; Aminoglutethimide; Androgens; Animals; Cytochrome P-450 Enzyme Inhibitors; Dogs; Estradiol; Flutamide; Gonadotropin-Releasing Hormone; Ketoconazole; Luteinizing Hormone; Male; Pregnenolone; Progesterone; Steroid 17-alpha-Hydroxylase; Testis; Testosterone; Triptorelin Pamoate | 1988 |
[Separation and characterization by high pressure liquid chromatography of delta(4)-3-ketosteroids synthetized from 3H-pregnenolone by an ectopic adrenal tumor treated with ketoconazole].
Topics: Adrenal Gland Neoplasms; Chromatography, High Pressure Liquid; Female; Humans; In Vitro Techniques; Ketoconazole; Ketosteroids; Pregnenolone | 1987 |
Effect of ketoconazole (an imidazole antimycotic agent) and other inhibitors of steroidogenesis on cytochrome P450-catalyzed reactions.
Topics: 18-Hydroxycorticosterone; Adrenal Cortex; Aminoglutethimide; Animals; Cattle; Cholesterol; Corticosterone; Cytochrome P-450 Enzyme Inhibitors; Desoxycorticosterone; Electron Transport; In Vitro Techniques; Ketoconazole; Mitochondria; Pregnenolone; Steroids | 1986 |
Progesterone 16 alpha-hydroxylase activity is catalyzed by human cytochrome P450 17 alpha-hydroxylase.
Topics: 17-alpha-Hydroxyprogesterone; Adrenal Glands; Animals; Aryl Hydrocarbon Hydroxylases; Cell Line, Transformed; Chlorocebus aethiops; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C9; DNA; Humans; Hydroxyprogesterones; Ketoconazole; Kidney; Kinetics; Male; Microsomes; NADP; Pregnenolone; Progesterone; Steroid 16-alpha-Hydroxylase; Steroid 17-alpha-Hydroxylase; Steroid Hydroxylases; Testis; Transfection | 1993 |
Fluconazole inhibits human adrenocortical steroidogenesis in vitro.
Topics: 17-alpha-Hydroxyprogesterone; Adrenal Cortex; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cells, Cultured; Cortodoxone; Desoxycorticosterone; Fluconazole; Humans; Hydrocortisone; Ketoconazole; Pregnenolone; Progesterone | 2012 |
Inhibition of pregnane X receptor pathway contributes to the cell growth inhibition and apoptosis of anticancer agents in ovarian cancer cells.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cisplatin; Female; Humans; Ketoconazole; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Paclitaxel; Phthalic Acids; Pregnane X Receptor; Pregnenolone; Receptors, Steroid; RNA, Small Interfering; Signal Transduction | 2016 |
Dose- and time-dependent changes in blood and adrenal levels of multiple steroids in rats after administration of ketoconazole with or without ACTH.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Chromatography, Liquid; Desoxycorticosterone; Dose-Response Relationship, Drug; Ketoconazole; Male; Pregnenolone; Progesterone; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry; Time Factors | 2019 |
Stepwise binding of inhibitors to human cytochrome P450 17A1 and rapid kinetics of inhibition of androgen biosynthesis.
Topics: Androgens; Androstenes; Antineoplastic Agents, Hormonal; Catalytic Domain; Cytochrome P-450 CYP3A; Enzyme Inhibitors; Humans; Imidazoles; Ketoconazole; Kinetics; Male; Naphthalenes; Pregnenolone; Progesterone; Prostatic Neoplasms; Steroid 17-alpha-Hydroxylase | 2021 |
The neurosteroid pregnenolone is synthesized by a mitochondrial P450 enzyme other than CYP11A1 in human glial cells.
Topics: Aminoglutethimide; Cholesterol; Cholesterol Side-Chain Cleavage Enzyme; Humans; Ketoconazole; Neuroglia; Neurosteroids; Pregnenolone; Reactive Oxygen Species | 2022 |