ketoconazole and posaconazole

ketoconazole has been researched along with posaconazole in 38 studies

Research

Studies (38)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's8 (21.05)29.6817
2010's23 (60.53)24.3611
2020's7 (18.42)2.80

Authors

AuthorsStudies
Emami, S; Keighobadi, M; Tavangar, P1
Wang, SQ; Wang, YF; Xu, Z1
Guengerich, FP; Hargrove, TY; Lepesheva, GI; Nes, WD; Rachakonda, G; Villalta, F; Wawrzak, Z1
Alcolea, V; Beltran-Hortelano, I; Font, M; Pérez-Silanes, S1
Delabio, LC; Dutra, JP; Hembecker, M; Kita, DH; Moure, VR; Pereira, GDS; Scheiffer, G; Valdameri, G; Zattoni, IF1
Almyroudis, NG; Fothergill, AW; Kusne, S; Rinaldi, MG; Sutton, DA1
Cano, J; Gené, J; Guarro, J; Marimon, R; Serena, C1
Azor, M; Cano, J; Fothergill, AW; Gené, J; Guarro, J; Rinaldi, MG; Sutton, DA1
Buckner, FS; Gelb, MH; Karimi, M; Kraus, JM; Lepesheva, GI; Verlinde, CL1
Gao, C; Pang, G; Sun, S; Wang, B; Xu, Y; Zhao, D; Zhou, L1
Arif, J; Buckner, FS; Chennamaneni, NK; Gelb, MH; Karimi, M; Kraus, JM; McGuffin, SA; Tatipaka, HB; Verlinde, CL1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Benhamou, RI; Dorot, O; Elias, R; Fridman, M; Jaber, QZ; Oved, K; Pichinuk, E; Zada, SL1
Almeida, D; de Nazareth S L de Meirelles, M; Pereira, MC; Silva, DT; Urbina, JA1
Cano, J; Gené, J; Gilgado, F; Guarro, J; Serena, C1
Krishna, G; Ma, L; Martinho, M; McLeod, J; Moton, A; Savant, I; Seiberling, M1
Accoceberry, I; Bernadou, JM; Breilh, D; Gordien, JB; Pigneux, A; Rouault, A; Saux, MC; Tabrizi, R; Vigouroux, S1
Heeres, J; Lewi, P; Meerpoel, L1
Fahal, AH; van Belkum, A; van de Sande, WW1
Cafarchia, C; Figueredo, LA; Iatta, R; Montagna, MT; Otranto, D1
Cuenca-Estrella, M; Escribano, P; Guinea, J; Martín-Mazuelos, E; Pemán, J; Sánchez-Reus, F; Zaragoza, Ó1
Jiang, J; Mathur, R; Pandharkar, T; Schmittgen, TD; Shaha, C; Werbovetz, KA; Zhu, X1
Bulanda, M; Jagielski, T; Skóra, M1
Buettner, B; Knoth, H; Scriba, GK1
Augustijns, P; Brouwers, J; Kourentas, A; Reppas, C; Stavrinoudakis, N; Symillides, M; Symillidis, A; Vertzoni, M1
Cristofoletti, R; Dressman, JB; Patel, N2
Brown, MS; Das, A; De Brabander, JK; Goldstein, JL; Li, X; Liang, Q; Lu, F; Trinh, MN1
Chen, C; Han, HS; Kano, R; Noli, C1
Almeida-Paes, R; Brito-Santos, F; Figueiredo-Carvalho, MHG; Gutierrez-Galhardo, MC; Machado, ACS; Oliveira, MME; Pereira, SA; Zancopé-Oliveira, RM1
McComiskey, KPM; Tajber, L1
Agnihotri, S; Aldape, KD; Bunda, S; Burrell, K; Chen, EX; Jalali, S; Karimi, S; Kumar, S; Li, M; Liu, J; Mamatjan, Y; Mansouri, A; Mansouri, S; Nejad, R; Singh, O; Singh, SK; Vartanian, A; Zadeh, G1
Dastgheib, L; Ghasemi, N; Jowkar, F; Nouraei, H; Pakshir, K; Zomorodian, K1
Abou El-Alamin, MM; Aboul-Enein, HY; Atia, MA; Sultan, MA1
Cheng, G; Huang, L; Li, T; Luo, X; Xue, X; Zhang, Y1
Amidon, GE; Kataoka, M; Minami, K; Takagi, T; Yamashita, S1
Nunes Rodrigues, TC; Vandenabeele, SI1

Reviews

6 review(s) available for ketoconazole and posaconazole

ArticleYear
An overview of azoles targeting sterol 14α-demethylase for antileishmanial therapy.
    European journal of medicinal chemistry, 2017, Jul-28, Volume: 135

    Topics: 14-alpha Demethylase Inhibitors; Antiprotozoal Agents; Azoles; Humans; Leishmania; Molecular Structure; Sterol 14-Demethylase

2017
Tetrazole hybrids and their antifungal activities.
    European journal of medicinal chemistry, 2019, May-15, Volume: 170

    Topics: Animals; Antifungal Agents; Azoles; Fungi; Humans; Mycoses; Pyridines; Pyrimidines; Quinolines; Structure-Activity Relationship; Tetrazoles

2019
Examination of multiple Trypanosoma cruzi targets in a new drug discovery approach for Chagas disease.
    Bioorganic & medicinal chemistry, 2022, 03-15, Volume: 58

    Topics: Chagas Disease; Drug Discovery; Humans; Molecular Structure; Oxidative Stress; Parasitic Sensitivity Tests; Trypanocidal Agents; Trypanosoma cruzi

2022
Targeting breast cancer resistance protein (BCRP/ABCG2): Functional inhibitors and expression modulators.
    European journal of medicinal chemistry, 2022, Jul-05, Volume: 237

    Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; Breast Neoplasms; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Humans; Neoplasm Proteins; Neoplastic Stem Cells

2022
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Conazoles.
    Molecules (Basel, Switzerland), 2010, Jun-09, Volume: 15, Issue:6

    Topics: Antifungal Agents; Fluconazole; Itraconazole; Ketoconazole; Miconazole; Molecular Structure; Pyrimidines; Structure-Activity Relationship; Triazoles; Voriconazole

2010

Trials

1 trial(s) available for ketoconazole and posaconazole

ArticleYear
Effects of oral posaconazole on the pharmacokinetic properties of oral and intravenous midazolam: a phase I, randomized, open-label, crossover study in healthy volunteers.
    Clinical therapeutics, 2009, Volume: 31, Issue:2

    Topics: Adult; Anti-Anxiety Agents; Antifungal Agents; Area Under Curve; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Female; Half-Life; Humans; Injections, Intravenous; Ketoconazole; Male; Midazolam; Middle Aged; Triazoles

2009

Other Studies

31 other study(ies) available for ketoconazole and posaconazole

ArticleYear
Relaxed Substrate Requirements of Sterol 14α-Demethylase from
    Journal of medicinal chemistry, 2021, 12-09, Volume: 64, Issue:23

    Topics: 14-alpha Demethylase Inhibitors; Ligands; Naegleria fowleri; Sterol 14-Demethylase; Substrate Specificity

2021
In vitro susceptibilities of 217 clinical isolates of zygomycetes to conventional and new antifungal agents.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:7

    Topics: Amphotericin B; Antifungal Agents; Caspofungin; Echinocandins; Fluconazole; Flucytosine; Humans; In Vitro Techniques; Itraconazole; Ketoconazole; Lipopeptides; Microbial Sensitivity Tests; Mucormycosis; Peptides, Cyclic; Pyrimidines; Triazoles; Voriconazole

2007
In vitro antifungal susceptibilities of five species of sporothrix.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:2

    Topics: Animals; Antifungal Agents; Drug Resistance, Fungal; Humans; Microbial Sensitivity Tests; Species Specificity; Sporothrix; Sporotrichosis

2008
In vitro antifungal susceptibility and molecular characterization of clinical isolates of Fusarium verticillioides (F. moniliforme) and Fusarium thapsinum.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:6

    Topics: Animals; Antifungal Agents; Drug Resistance, Fungal; Fusarium; Humans; Microbial Sensitivity Tests; Molecular Sequence Data; Mycoses; Naphthalenes; Sequence Analysis, DNA; Terbinafine; Triazoles; Tubulin

2008
Rational modification of a candidate cancer drug for use against Chagas disease.
    Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6

    Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Chagas Disease; Humans; Mice; Mice, Inbred BALB C; Models, Molecular; Quinolones; Rats; Trypanocidal Agents

2009
In vitro activity of thimerosal against ocular pathogenic fungi.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:1

    Topics: Alternaria; Amphotericin B; Antifungal Agents; Aspergillus; Eye Infections, Fungal; Fungi; Fusarium; Humans; Microbial Sensitivity Tests; Natamycin; Thimerosal

2010
Second generation analogues of the cancer drug clinical candidate tipifarnib for anti-Chagas disease drug discovery.
    Journal of medicinal chemistry, 2010, May-27, Volume: 53, Issue:10

    Topics: 3T3 Cells; Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Chagas Disease; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; Isoenzymes; Mice; Models, Molecular; Protein Binding; Quinolones; Rats; Sterol 14-Demethylase; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi

2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Antifungal activity, mode of action variability, and subcellular distribution of coumarin-based antifungal azoles.
    European journal of medicinal chemistry, 2019, Oct-01, Volume: 179

    Topics: Antifungal Agents; Azoles; Candida; Cell Survival; Coumarins; Dose-Response Relationship, Drug; HEK293 Cells; Hep G2 Cells; Humans; Microbial Sensitivity Tests; Molecular Structure; Optical Imaging; Structure-Activity Relationship

2019
Cytoskeleton reassembly in cardiomyocytes infected by Trypanosoma cruzi is triggered by treatment with ergosterol biosynthesis inhibitors.
    International journal of antimicrobial agents, 2006, Volume: 27, Issue:6

    Topics: Animals; Cells, Cultured; Cytoskeleton; Ergosterol; Ketoconazole; Mice; Myocytes, Cardiac; Myofibrils; Triazoles; Trypanocidal Agents; Trypanosoma cruzi

2006
Antifungal susceptibilities of the species of the Pseudallescheria boydii complex.
    Antimicrobial agents and chemotherapy, 2006, Volume: 50, Issue:12

    Topics: Amphotericin B; Antifungal Agents; Candida; Drug Resistance, Fungal; Echinocandins; Fluconazole; Flucytosine; Humans; Itraconazole; Ketoconazole; Lipopeptides; Lipoproteins; Micafungin; Microbial Sensitivity Tests; Naphthalenes; Peptides, Cyclic; Pseudallescheria; Pyrimidines; Quality Control; Quinazolines; Scedosporium; Terbinafine; Thiazoles; Triazoles; Voriconazole

2006
Simultaneous determination of five systemic azoles in plasma by high-performance liquid chromatography with ultraviolet detection.
    Journal of pharmaceutical and biomedical analysis, 2009, Dec-05, Volume: 50, Issue:5

    Topics: Calibration; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Drug Monitoring; Drug Stability; Fluconazole; Humans; Itraconazole; Ketoconazole; Pyrimidines; Quality Control; Reproducibility of Results; Spectrophotometry, Ultraviolet; Time Factors; Triazoles; Ultraviolet Rays; Voriconazole

2009
In vitro susceptibility of Madurella mycetomatis to posaconazole and terbinafine.
    Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:4

    Topics: Antifungal Agents; Itraconazole; Ketoconazole; Madurella; Microbial Sensitivity Tests; Naphthalenes; Terbinafine; Triazoles

2011
In vitro antifungal susceptibility of Malassezia pachydermatis from dogs with and without skin lesions.
    Veterinary microbiology, 2012, Mar-23, Volume: 155, Issue:2-4

    Topics: Animals; Antifungal Agents; Dermatomycoses; Dog Diseases; Dogs; Fluconazole; Itraconazole; Ketoconazole; Malassezia; Miconazole; Naphthalenes; Pyrimidines; Terbinafine; Triazoles; Voriconazole

2012
Molecular identification and antifungal susceptibility of yeast isolates causing fungemia collected in a population-based study in Spain in 2010 and 2011.
    Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:3

    Topics: Antifungal Agents; Candida; Candida albicans; Candida glabrata; Candida tropicalis; Candidiasis; Drug Resistance, Fungal; Echinocandins; Fungemia; Humans; Itraconazole; Ketoconazole; Microbial Sensitivity Tests; Pyrimidines; Spain; Triazoles; Voriconazole

2014
Studies on the antileishmanial mechanism of action of the arylimidamide DB766: azole interactions and role of CYP5122A1.
    Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:8

    Topics: Amidines; Animals; Antiprotozoal Agents; Axenic Culture; Blotting, Western; Cricetinae; Drug Combinations; Drug Resistance; Drug Synergism; Furans; Gene Expression Regulation; Ketoconazole; Leishmania donovani; Life Cycle Stages; Mice; Phosphorylcholine; Protozoan Proteins; Sterol 14-Demethylase; Triazoles

2014
In vitro activities of a wide panel of antifungal drugs against various Scopulariopsis and Microascus species.
    Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:9

    Topics: Amphotericin B; Antifungal Agents; Ascomycota; Caspofungin; Drug Resistance, Fungal; Echinocandins; Fluconazole; Flucytosine; Itraconazole; Ketoconazole; Lipopeptides; Microbial Sensitivity Tests; Scopulariopsis; Triazoles; Voriconazole

2015
Electrochemical behavior of the antifungal agents itraconazole, posaconazole and ketoconazole at a glassy carbon electrode.
    Die Pharmazie, 2015, Volume: 70, Issue:6

    Topics: Antifungal Agents; Carbon; Electrochemical Techniques; Electrochemistry; Electrodes; Indicators and Reagents; Itraconazole; Ketoconazole; Solutions; Triazoles

2015
An in vitro biorelevant gastrointestinal transfer (BioGIT) system for forecasting concentrations in the fasted upper small intestine: Design, implementation, and evaluation.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2016, Jan-20, Volume: 82

    Topics: Dipyridamole; Fasting; Gastric Mucosa; Gastrointestinal Tract; In Vitro Techniques; Intestine, Small; Ketoconazole; Models, Biological; Ranitidine; Triazoles

2016
Differences in Food Effects for 2 Weak Bases With Similar BCS Drug-Related Properties: What Is Happening in the Intestinal Lumen?
    Journal of pharmaceutical sciences, 2016, Volume: 105, Issue:9

    Topics: Adolescent; Adult; Biopharmaceutics; Cell Membrane; Computer Simulation; Fasting; Female; Food-Drug Interactions; Gastric Emptying; Humans; Intestinal Absorption; Intestinal Mucosa; Ketoconazole; Male; Middle Aged; Triazoles; Young Adult

2016
Assessment of Bioequivalence of Weak Base Formulations Under Various Dosing Conditions Using Physiologically Based Pharmacokinetic Simulations in Virtual Populations. Case Examples: Ketoconazole and Posaconazole.
    Journal of pharmaceutical sciences, 2017, Volume: 106, Issue:2

    Topics: Administration, Oral; Adult; Antifungal Agents; Carbonated Beverages; Computer Simulation; Fasting; Gastric Mucosa; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Intestine, Small; Ketoconazole; Models, Biological; Solubility; Therapeutic Equivalency; Triazoles

2017
Triazoles inhibit cholesterol export from lysosomes by binding to NPC1.
    Proceedings of the National Academy of Sciences of the United States of America, 2017, 01-03, Volume: 114, Issue:1

    Topics: Androstenes; Animals; Antifungal Agents; Binding Sites; Biological Transport; Carrier Proteins; Cell Line; CHO Cells; Cholesterol; Cricetulus; Endocytosis; Itraconazole; Ketoconazole; Lysosomes; Membrane Glycoproteins; Protein Binding; Protein Domains; Triazoles

2017
Comparison of two in vitro antifungal sensitivity tests and monitoring during therapy of Sporothrix schenckii sensu stricto in Malaysian cats.
    Veterinary dermatology, 2017, Volume: 28, Issue:1

    Topics: Amphotericin B; Animals; Antifungal Agents; Cat Diseases; Cats; In Vitro Techniques; Itraconazole; Ketoconazole; Malaysia; Microbial Sensitivity Tests; Naphthalenes; Sporothrix; Sporotrichosis; Terbinafine; Triazoles

2017
Minimal inhibitory concentration distributions and epidemiological cutoff values of five antifungal agents against Sporothrix brasiliensis.
    Memorias do Instituto Oswaldo Cruz, 2017, Volume: 112, Issue:5

    Topics: Amphotericin B; Animals; Antifungal Agents; Cats; Drug Resistance, Fungal; Humans; Itraconazole; Ketoconazole; Microbial Sensitivity Tests; Naphthalenes; Sporothrix; Terbinafine; Triazoles

2017
Comparison of particle size methodology and assessment of nanoparticle tracking analysis (NTA) as a tool for live monitoring of crystallisation pathways.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2018, Volume: 130

    Topics: Antifungal Agents; Chemistry, Pharmaceutical; Crystallization; Dynamic Light Scattering; Excipients; Itraconazole; Ketoconazole; Nanoparticles; Particle Size; Polyethylene Glycols; Solvents; Technology, Pharmaceutical; Triazoles

2018
Ketoconazole and Posaconazole Selectively Target HK2-expressing Glioblastoma Cells.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2019, 01-15, Volume: 25, Issue:2

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Energy Metabolism; Gene Expression Regulation, Neoplastic; Glioblastoma; Hexokinase; Humans; Ketoconazole; Male; Mice; Triazoles; Xenograft Model Antitumor Assays

2019
Identification and Antifungal Activity Profile of Candida Species Isolated from Patients with Pemphigus Vulgaris with Oral Lesions.
    Acta dermatovenerologica Croatica : ADC, 2019, Volume: 27, Issue:3

    Topics: Adult; Amphotericin B; Antifungal Agents; Candida; Candidiasis, Oral; Disk Diffusion Antimicrobial Tests; Econazole; Female; Fluconazole; Humans; Itraconazole; Ketoconazole; Male; Pemphigus; Triazoles

2019
Novel Application of Pentabromobenzyl Column for Simultaneous Determination of Eight Antifungal Drugs Using High-performance Liquid Chromatography.
    Combinatorial chemistry & high throughput screening, 2020, Volume: 23, Issue:10

    Topics: Antifungal Agents; Chromatography, High Pressure Liquid; Clotrimazole; Humans; Hydrocarbons, Brominated; Imidazoles; Ketoconazole; Liquid-Liquid Extraction; Molecular Structure; Thiophenes; Triazoles; Voriconazole

2020
Differential Impacts of Azole Antifungal Drugs on the Pharmacokinetic Profiles of Dasatinib in Rats by LC-MS-MS.
    Current drug metabolism, 2020, Volume: 21, Issue:13

    Topics: Administration, Oral; Animals; Antifungal Agents; Area Under Curve; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dasatinib; Drug Interactions; Drug Monitoring; Humans; Itraconazole; Ketoconazole; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Models, Animal; Protein Kinase Inhibitors; Rats; Tandem Mass Spectrometry; Triazoles; Voriconazole

2020
In Vitro-In Vivo Correlation in Cocrystal Dissolution: Consideration of Drug Release Profiles Based on Coformer Dissolution and Absorption Behavior.
    Molecular pharmaceutics, 2021, 11-01, Volume: 18, Issue:11

    Topics: 4-Aminobenzoic Acid; Adjuvants, Pharmaceutic; Administration, Oral; Animals; Chemistry, Pharmaceutical; Crystallization; Drug Compounding; Drug Liberation; Gastrointestinal Absorption; Itraconazole; Ketoconazole; Male; Rats; Solubility; Triazoles

2021
Pilot study of dogs with suppurative and non-suppurative Malassezia otitis: A case series.
    BMC veterinary research, 2021, Nov-18, Volume: 17, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Antifungal Agents; Dermatitis; Dog Diseases; Dogs; Ear Canal; Exudates and Transudates; Hypersensitivity; Immunoglobulin E; Intradermal Tests; Ketoconazole; Malassezia; Mometasone Furoate; Neutrophils; Otitis; Otitis Media, Suppurative; Prednisolone; Treatment Outcome; Triazoles

2021