ketoconazole has been researched along with piperidines in 27 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.70) | 18.7374 |
| 1990's | 10 (37.04) | 18.2507 |
| 2000's | 7 (25.93) | 29.6817 |
| 2010's | 9 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hechtman, DH; Jageneau, A | 1 |
| Dunbar, F | 1 |
| Cayen, MN; Chen, KJ; Clement, RP; Huie, K; Snow, M; Yumibe, N | 1 |
| del Prado, M; Egan, RW; Hey, JA; Kreutner, W | 1 |
| Llenas, J; Roberts, DJ | 1 |
| del Prado, M; Egan, RW; Hey, JA; Kreutner, W; Sherwood, J | 1 |
| Babinchak, TJ; Chan-Tompkins, NH | 1 |
| Friedhoff, LT; Perdomo, CA; Tiseo, PJ | 1 |
| Grover, M; Hall, N; Hassell, A; Hunt, T; Lee, P; Mechlinski, W; Pesco-Koplowitz, L; Smith, R; Travers, S; Wiesinger, B; Zhou, H | 1 |
| Artursson, P; Hidalgo, IJ; Raeissi, SD; Segura-Aguilar, J | 1 |
| Chaikin, P; Garcia, JD; Gillen, M; Morganroth, J; Moss, AJ; Roberts, DJ | 1 |
| Rojas-Fernandez, C | 1 |
| Bajad, S; Bedi, KL; Johri, RK; Singh, J; Singh, K | 1 |
| Hansen, KT; Hatorp, V; Thomsen, MS | 1 |
| Black, ML; Duncan, JN; Toth, LN; Yamazaki, S | 1 |
| Chaikin, P; Gillen, MS; Malik, M; Pentikis, H; Rhodes, GR; Roberts, DJ | 1 |
| Ballard, ME; Cowart, M; Decker, MW; Esbenshade, TA; Faghih, R; Fox, GB; Hancock, AA; Pan, L; Roberts, S; Rueter, LE; Zhang, M | 1 |
| Chowdhury, SK; Ghosal, A; Hapangama, N; Su, AD; Tong, W; Yuan, Y; Zbaida, S | 1 |
| Adams, LM; Apseloff, G; Blum, RA; Gainer, SD; Johnson, BM; Kirby, LC; Lebowitz, PF; Morrison, RA; Schutz, RA; Zhang, K | 1 |
| Azzam, S; Blanco, N; Kabbaj, M; Reinbolt, E; Roupe, K; Sologuren, A; Tyl, B; Valiente, R; Wheeler, W | 1 |
| Chen, Y; Hickman, D; Hsieh, F; Shou, M; Skiles, GL | 1 |
| Choi, DH; Choi, JS; Li, C | 1 |
| Hochfeld, M; Meng, X; Potkin, SG; Preskorn, S | 1 |
| Ahlers, CM; Christopher, LJ; Has, T; Kurland, JF; Masson, E; Roongta, V; Shen, G; Vakkalagadda, B; Yang, Z; Zhang, S | 1 |
| De Jong, J; de Zwart, L; Mannaert, E; Monshouwer, M; Snoeys, J; Sukbuntherng, J | 1 |
| Goda, H; Ito, K; Komatsu, S; Kudo, T; Tanaka, R; Yokosuka, Y | 1 |
| Chen, Y; Guo, X; Li, Q; Li, W; Peng, Y; Zhao, G; Zheng, J | 1 |
1 review(s) available for ketoconazole and piperidines
| Article | Year |
|---|---|
A review of the cardiac systemic side-effects of antihistamines: ebastine.
Topics: Adult; Butyrophenones; Child; Clinical Trials as Topic; Drug Interactions; Erythromycin; Heart; Histamine H1 Antagonists; Humans; Ketoconazole; Piperidines | 1999 |
9 trial(s) available for ketoconazole and piperidines
| Article | Year |
|---|---|
Inhibition of cold-induced vasoconstriction with ketanserin.
Topics: Adult; Cold Temperature; Hand; Humans; Ibuprofen; Ketanserin; Ketoconazole; Male; Middle Aged; Piperidines; Regional Blood Flow; Serotonin; Skin Temperature; Thromboxane B2; Vasoconstriction | 1985 |
Concurrent administration of donepezil HCl and ketoconazole: assessment of pharmacokinetic changes following single and multiple doses.
Topics: Administration, Oral; Adult; Antifungal Agents; Cholinesterase Inhibitors; Cross-Over Studies; Donepezil; Dose-Response Relationship, Drug; Drug Interactions; Humans; Indans; Ketoconazole; Male; Middle Aged; Piperidines | 1998 |
Lack of effect of erythromycin and ketoconazole on the pharmacokinetics and pharmacodynamics of steady-state intranasal levocabastine.
Topics: Administration, Intranasal; Adolescent; Adult; Anti-Bacterial Agents; Anti-Infective Agents; Area Under Curve; Biological Availability; Bradycardia; Cross-Over Studies; Drug Interactions; Electrocardiography; Erythromycin; Headache; Heart Block; Histamine H1 Antagonists; Humans; Ketoconazole; Male; Middle Aged; Piperidines; Rhinitis; Time Factors; Virus Diseases | 1999 |
Influence of drugs interacting with CYP3A4 on the pharmacokinetics, pharmacodynamics, and safety of the prandial glucose regulator repaglinide.
Topics: Adult; Area Under Curve; Blood Glucose; Carbamates; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Half-Life; Humans; Hypoglycemic Agents; Ketoconazole; Male; Piperidines; Rifampin; Simvastatin | 2003 |
Co-administration of ketoconazole with H1-antagonists ebastine and loratadine in healthy subjects: pharmacokinetic and pharmacodynamic effects.
Topics: Adolescent; Adult; Antifungal Agents; Butyrophenones; Double-Blind Method; Drug Combinations; Electrocardiography; Heart Rate; Histamine H1 Antagonists; Humans; Ketoconazole; Loratadine; Male; Piperidines | 2005 |
Ketoconazole and rifampin significantly affect the pharmacokinetics, but not the safety or QTc interval, of casopitant, a neurokinin-1 receptor antagonist.
Topics: Adolescent; Adult; Antiemetics; Area Under Curve; Cytochrome P-450 CYP3A Inhibitors; Electrocardiography; Enzyme Induction; Humans; Ketoconazole; Middle Aged; Neurokinin-1 Receptor Antagonists; Piperazines; Piperidines; Rifampin; Young Adult | 2010 |
Lack of significant effect of bilastine administered at therapeutic and supratherapeutic doses and concomitantly with ketoconazole on ventricular repolarization: results of a thorough QT study (TQTS) with QT-concentration analysis.
Topics: Adult; Anti-Allergic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzimidazoles; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Electrocardiography; Female; Half-Life; Histamine H1 Antagonists, Non-Sedating; Humans; Ketoconazole; Male; Metabolic Clearance Rate; Piperidines; Young Adult | 2012 |
A thorough QTc study of 3 doses of iloperidone including metabolic inhibition via CYP2D6 and/or CYP3A4 and a comparison to quetiapine and ziprasidone.
Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dibenzothiazepines; Drug Administration Schedule; Drug Interactions; Drug Monitoring; Electrocardiography; Enzyme Inhibitors; Female; Genotype; Heart Rate; Humans; Isoxazoles; Ketoconazole; Linear Models; Long QT Syndrome; Male; Middle Aged; Paroxetine; Pharmacogenetics; Phenotype; Piperazines; Piperidines; Quetiapine Fumarate; Thiazoles; United States; Young Adult | 2013 |
Ibrutinib Dosing Strategies Based on Interaction Potential of CYP3A4 Perpetrators Using Physiologically Based Pharmacokinetic Modeling.
Topics: Adenine; Alkynes; Azithromycin; Benzoxazines; Carbamazepine; Cyclopropanes; Cytochrome P-450 CYP3A Inducers; Cytochrome P-450 CYP3A Inhibitors; Drug Dosage Calculations; Drug Interactions; Fluvoxamine; Humans; Ketoconazole; Male; Models, Biological; Piperidines; Pyrazoles; Pyrimidines; Rifampin | 2016 |
17 other study(ies) available for ketoconazole and piperidines
| Article | Year |
|---|---|
Cisapride labelling change.
Topics: Cisapride; Contraindications; Drug Interactions; Drug Labeling; Humans; Ketoconazole; Piperidines | 1995 |
Identification of human liver cytochrome P450 enzymes that metabolize the nonsedating antihistamine loratadine. Formation of descarboethoxyloratadine by CYP3A4 and CYP2D6.
Topics: Anti-Bacterial Agents; Antifungal Agents; Antimalarials; Binding Sites; Biotransformation; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Histamine H1 Antagonists; Humans; In Vitro Techniques; Ketoconazole; Loratadine; Microsomes, Liver; Mixed Function Oxygenases; Models, Molecular; Oxidation-Reduction; Piperidines; Pyridines; Quinidine; Recombinant Proteins; Substrate Specificity; Troleandomycin | 1996 |
Cardiotoxic and drug interaction profile of the second generation antihistamines ebastine and terfenadine in an experimental animal model of torsade de pointes.
Topics: Animals; Butyrophenones; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Electrocardiography; Guinea Pigs; Heart Diseases; Histamine H1 Antagonists; Ketoconazole; Liver; Male; Mixed Function Oxygenases; Piperidines; Terfenadine; Torsades de Pointes | 1996 |
Some observations on the cardiotoxic and drug interaction profiles of second generation antihistamines as measured in the guinea pig.
Topics: Animals; Antifungal Agents; Butyrophenones; Disease Models, Animal; Drug Interactions; Electrocardiography; Guinea Pigs; Histamine H1 Antagonists; Injections, Intravenous; Ketoconazole; Piperidines; Terfenadine; Torsades de Pointes | 1996 |
The guinea pig model for assessing cardiotoxic proclivities of second generation antihistamines.
Topics: Animals; Antifungal Agents; Butyrophenones; Cats; Disease Models, Animal; Drug Interactions; Guinea Pigs; Histamine H1 Antagonists; Humans; Ketoconazole; Piperidines; Terfenadine; Torsades de Pointes | 1996 |
Cardiac arrhythmias associated with coadministration of azole compounds and cisapride.
Topics: Antifungal Agents; Arrhythmias, Cardiac; Cisapride; Drug Interactions; Humans; Ketoconazole; Piperidines | 1997 |
Interplay between CYP3A-mediated metabolism and polarized efflux of terfenadine and its metabolites in intestinal epithelial Caco-2 (TC7) cell monolayers.
Topics: Anti-Anxiety Agents; Antifungal Agents; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Calcium Channel Blockers; Catalytic Domain; Cell Polarity; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Digoxin; Enzyme Inhibitors; Epithelial Cells; Gene Expression; Histamine H1 Antagonists; Humans; Hydroxylation; Intestinal Mucosa; Intestines; Ketoconazole; Kinetics; Oligonucleotide Probes; Oxidoreductases, N-Demethylating; Piperidines; RNA, Messenger; Terfenadine; Tritium; Verapamil | 1999 |
Drug interactions and donepezil.
Topics: Antidepressive Agents, Second-Generation; Antifungal Agents; Cholinesterase Inhibitors; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Donepezil; Drug Interactions; Enzyme Inhibitors; Humans; Indans; Ketoconazole; Paroxetine; Piperidines | 2000 |
Simple high-performance liquid chromatography method for the simultaneous determination of ketoconazole and piperine in rat plasma and hepatocyte culture.
Topics: Alkaloids; Animals; Benzodioxoles; Biological Availability; Chromatography, High Pressure Liquid; Hepatocytes; Ketoconazole; Male; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Wistar; Sensitivity and Specificity; Spectrophotometry, Ultraviolet | 2002 |
Comparison of prediction methods for in vivo clearance of (S,S)-3-[3-(methylsulfonyl)phenyl]-1-propylpiperidine hydrochloride, a dopamine D2 receptor antagonist, in humans.
Topics: Adult; Animals; Chromatography, Liquid; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Dogs; Dopamine D2 Receptor Antagonists; Drug Evaluation, Preclinical; Drug Interactions; Female; Haloperidol; Hepatocytes; Humans; Injections, Intravenous; Ketoconazole; Macaca fascicularis; Male; Metabolic Clearance Rate; Middle Aged; Piperidines; Quinidine; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Species Specificity; Spectrometry, Mass, Electrospray Ionization; Sulfones | 2004 |
Lack of cataleptogenic potentiation with non-imidazole H3 receptor antagonists reveals potential drug-drug interactions between imidazole-based H3 receptor antagonists and antipsychotic drugs.
Topics: Animals; Antipsychotic Agents; Benzofurans; Brain Chemistry; Cataplexy; Cytochrome P-450 Enzyme System; Drug Combinations; Drug Synergism; Haloperidol; Histamine; Histamine Antagonists; Imidazoles; Ketoconazole; Male; Metabolic Clearance Rate; Piperidines; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Histamine H3; Risperidone; Schizophrenia | 2005 |
Identification of human liver cytochrome P450 enzymes responsible for the metabolism of lonafarnib (Sarasar).
Topics: Antineoplastic Agents; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Humans; Ketoconazole; Microsomes, Liver; Oxidation-Reduction; Piperidines; Pyridines; Recombinant Proteins | 2006 |
A novel biotransformation of alkyl aminopyrrolidine to aminopiperidine ring by human CYP3A.
Topics: Biotransformation; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Humans; Hydroxylation; Ketoconazole; Magnetic Resonance Spectroscopy; Mass Spectrometry; Microsomes, Liver; Piperidines; Pyrimidinones; Pyrrolidines; Semicarbazides | 2011 |
Effects of efonidipine on the pharmacokinetics and pharmacodynamics of repaglinide: possible role of CYP3A4 and P-glycoprotein inhibition by efonidipine.
Topics: Animals; Antihypertensive Agents; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biocatalysis; Biological Availability; Blood Glucose; Carbamates; Cell Line, Tumor; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dihydropyridines; Drug Interactions; Humans; Hypoglycemic Agents; Ketoconazole; Male; Models, Biological; Nitrophenols; Organophosphorus Compounds; Pharmacological Phenomena; Piperidines; Rats; Rats, Sprague-Dawley; Rhodamine 123 | 2012 |
Inhibitory effect of ketoconazole on the pharmacokinetics of a multireceptor tyrosine kinase inhibitor BMS-690514 in healthy participants: assessing the mechanism of the interaction with physiologically-based pharmacokinetic simulations.
Topics: Adult; Antifungal Agents; Antineoplastic Agents; Area Under Curve; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Computer Simulation; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Genotype; Humans; Ketoconazole; Male; Middle Aged; Models, Biological; Piperidines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrroles; Triazines; Young Adult | 2013 |
Estimation of the Contribution of CYP2C8 and CYP3A4 in Repaglinide Metabolism by Human Liver Microsomes Under Various Buffer Conditions.
Topics: Acetates; Buffers; Carbamates; Cyclopropanes; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inducers; Cytochrome P-450 Enzyme Inhibitors; Drug Interactions; Humans; Hypoglycemic Agents; Ketoconazole; Microsomes, Liver; Piperidines; Quinolines; Sulfides | 2017 |
Tofacitinib Is a Mechanism-Based Inactivator of Cytochrome P450 3A4.
Topics: Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Enzyme Assays; Humans; Ketoconazole; Male; Microsomes, Liver; NADP; Piperidines; Pyrimidines; Pyrroles | 2019 |