ketoconazole has been researched along with phenobarbital in 31 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (12.90) | 18.7374 |
| 1990's | 5 (16.13) | 18.2507 |
| 2000's | 11 (35.48) | 29.6817 |
| 2010's | 10 (32.26) | 24.3611 |
| 2020's | 1 (3.23) | 2.80 |
| Authors | Studies |
|---|---|
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
| Glen, RC; Lowe, R; Mitchell, JB | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Sen, S; Sinha, N | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Karcz, T; Karolak-Wojciechowska, J; Kieć-Kononowicz, K; Kuder, K; Latacz, G; Schwed, JS; Stark, H; Łażewska, D | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Hammer, C; Modic, PK; Mraz, W | 1 |
| Hsieh, CY; Huang, JD | 1 |
| Breckenridge, AM; Guenthner, TM; Kitteringham, NR; Park, BK; Pirmohamed, M | 1 |
| Brooks, B; Brown, PS; Byers, LW; Capdevila, J; Muirhead, EE; Pitcock, JA | 1 |
| Heykants, J; Lavrijsen, K; Meuldermans, W; Thijs, D; van Houdt, J | 1 |
| Franklin, MR; Ritter, JK | 1 |
| Darvey, DL; Sorkin, EM | 1 |
| Grevel, J; Kahan, BD; Napoli, KL; Serino, F; Strobel, HW | 1 |
| Feierman, DE | 1 |
| Frosini, M; Fusi, F; Pessina, F; Sgaragli, GP; Tipton, KF; Valoti, M | 1 |
| Kagayama, A; Mitani, Y; Niwa, T; Shiraga, T; Terakawa, M; Tokuma, Y | 1 |
| Hurh, E; Kim, S; Kim, Y; Lee, A; Lee, E; Lee, M | 1 |
| Frame, SR; Ladics, GS; O'Connor, JC | 1 |
| Cui, YY; Lin, G; Liu, XQ | 1 |
| Funae, Y; Hiroi, T; Imaoka, S; Minamiyama, Y; Osada, M; Takemura, S; Toyokuni, S; Yukimura, T | 1 |
| Chou, CY; Chou, YC; Tien, JH; Ueng, YF | 1 |
| Gehlhaus, M; Meyer, RP; Schmitt, N; Volk, B | 1 |
| Kumar, V; Lee, CM; Morgan, ET; Riley, RI | 1 |
| Black, MB; Efremenko, A; Hartman, JK; Mallick, P; McMullen, PD; Moreau, M; Stern, A | 1 |
2 review(s) available for ketoconazole and phenobarbital
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Review of cimetidine drug interactions.
Topics: Adrenergic beta-Antagonists; Animals; Anti-Anxiety Agents; Anti-Bacterial Agents; Benzodiazepines; Cimetidine; Diet; Drug Interactions; Glucose; Guanidines; Histamine H1 Antagonists; Humans; Imidazoles; Insulin; Ketoconazole; Metoclopramide; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Phenytoin; Piperazines; Propantheline | 1983 |
29 other study(ies) available for ketoconazole and phenobarbital
| Article | Year |
|---|---|
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship | 2011 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Chlorophenoxy aminoalkyl derivatives as histamine H(3)R ligands and antiseizure agents.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroshock; Humans; Ligands; Male; Mice; Models, Molecular; Molecular Structure; Rats; Rats, Sprague-Dawley; Receptors, Histamine H3; Seizures; Structure-Activity Relationship | 2016 |
Impact of imipenem/cilastatin on cyclosporine metabolism and excretion.
Topics: Animals; Bile; Cilastatin; Cyclosporine; Cytosol; Imipenem; Ketoconazole; Liver; Male; Phenobarbital; Rats; Rats, Inbred Strains; Time Factors | 1992 |
Two-dimensional high-performance liquid chromatographic method to assay p-hydroxyphenylphenylhydantoin enantiomers in biological fluids and stereoselectivity of enzyme induction in phenytoin metabolism.
Topics: Acetone; Animals; Aroclors; Chlorodiphenyl (54% Chlorine); Chromatography, High Pressure Liquid; Cimetidine; Dexamethasone; Diazepam; Enzyme Induction; Female; Ketoconazole; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Phenytoin; Rats; Safrole; Sex Characteristics; Stereoisomerism; Sulfaphenazole | 1992 |
An investigation of the formation of cytotoxic, protein-reactive and stable metabolites from carbamazepine in vitro.
Topics: Animals; Ascorbic Acid; Biotransformation; Carbamazepine; Cell Death; Cytosol; Epoxide Hydrolases; Glutathione; Humans; Ketoconazole; Lymphocytes; Mice; Microsomes, Liver; Models, Chemical; Phenobarbital; Proteins | 1992 |
The renal antihypertensive endocrine function: its relation to cytochrome P-450.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Anastomosis, Surgical; Animals; Antihypertensive Agents; Blood Pressure; Cytochrome P-450 Enzyme System; Drug Interactions; Hepatectomy; Hypertension, Renovascular; Ketoconazole; Kidney; Kidney Medulla; Lipid Metabolism; Lipids; Liver; Male; Phenobarbital; Pyrazoles; Rats; Rats, Inbred Strains; Ureter | 1989 |
Interaction of miconazole, ketoconazole and itraconazole with rat-liver microsomes.
Topics: Aniline Hydroxylase; Animals; Cytochrome P-450 Enzyme Inhibitors; Itraconazole; Ketoconazole; Kinetics; Male; Methylcholanthrene; Miconazole; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Oxidoreductases, O-Demethylating; Phenobarbital; Rats | 1987 |
Induction of hepatic oxidative and conjugative drug metabolism in the hamster by N-substituted imidazoles.
Topics: Animals; Body Weight; Clotrimazole; Cricetinae; Cytochrome P-450 Enzyme System; Female; Glucuronates; Imidazoles; Ketoconazole; Male; Mesocricetus; Miconazole; Microsomes, Liver; Organ Size; Oxidation-Reduction; Phenobarbital; Sex Factors | 1987 |
Oxygen radical formation by the cytochrome P450 system as a cellular mechanism for cyclosporine toxicity.
Topics: Aminopyrine; Animals; Chloramphenicol; Cyclosporine; Cytochrome P-450 Enzyme System; Enzyme Induction; Free Radical Scavengers; Ketoconazole; Kinetics; Lipid Peroxidation; Male; Microsomes, Liver; NADP; Phenobarbital; Proadifen; Rats; Rats, Sprague-Dawley | 1994 |
Identification of cytochrome P450 3A1/2 as the major P450 isoform responsible for the metabolism of fentanyl by rat liver microsomes.
Topics: Anesthetics, Intravenous; Animals; Anti-Bacterial Agents; Antifungal Agents; Aryl Hydrocarbon Hydroxylases; Benzoflavones; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dealkylation; Enzyme Inhibitors; Erythromycin; Fentanyl; GABA Modulators; Gas Chromatography-Mass Spectrometry; Isoenzymes; Ketoconazole; Male; Microsomes, Liver; Mixed Function Oxygenases; Oxidation-Reduction; Phenobarbital; Rats; Rats, Sprague-Dawley; Sodium Chloride | 1996 |
Cytochrome P450-dependent N-dealkylation of L-deprenyl in C57BL mouse liver microsomes: effects of in vivo pretreatment with ethanol, phenobarbital, beta-naphthoflavone and L-deprenyl.
Topics: Animals; beta-Naphthoflavone; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Disulfiram; Enzyme Induction; Enzyme Inhibitors; Ethanol; Fomepizole; In Vitro Techniques; Isoenzymes; Ketoconazole; Mice; Mice, Inbred C57BL; Microsomes, Liver; Monoamine Oxidase Inhibitors; NADH, NADPH Oxidoreductases; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Pyrazoles; Selegiline | 2000 |
Stereoselective metabolism of cibenzoline, an antiarrhythmic drug, by human and rat liver microsomes: possible involvement of CYP2D and CYP3A.
Topics: Animals; Anti-Arrhythmia Agents; Aryl Hydrocarbon Hydroxylases; beta-Naphthoflavone; Cell Line; Chromatography, High Pressure Liquid; Clofibrate; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Female; Humans; Imidazoles; Ketoconazole; Kinetics; Male; Microsomes; Microsomes, Liver; Oxidoreductases, N-Demethylating; Phenobarbital; Quinidine; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Sex Factors; Stereoisomerism | 2000 |
Effects of enzyme inducers or inhibitors on the pharmacokinetics of intravenous parathion in rats.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Blotting, Western; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Drug Interactions; Enzyme Induction; Enzyme Inhibitors; Insecticides; Isoenzymes; Isoniazid; Ketoconazole; Male; Methylcholanthrene; Microsomes, Liver; Paraoxon; Parathion; Phenobarbital; Proadifen; Rats; Rats, Sprague-Dawley; Tissue Distribution | 2000 |
Evaluation of a 15-day screening assay using intact male rats for identifying steroid biosynthesis inhibitors and thyroid modulators.
Topics: Androgens; Animals; Antibody Formation; Antithyroid Agents; Aromatase Inhibitors; Body Weight; Drug Evaluation, Preclinical; Enzyme Inhibitors; Female; Hormones; Injections, Intraperitoneal; Ketoconazole; Male; Organ Size; Phenobarbital; Propylthiouracil; Rats; Rats, Sprague-Dawley; Spleen; Steroids; Thyroid Gland | 2002 |
Gender differences in microsomal metabolic activation of hepatotoxic clivorine in rat.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Dexamethasone; Enzyme Induction; Female; Ketoconazole; Male; Membrane Proteins; Microsomes, Liver; Phenobarbital; Pyrrolizidine Alkaloids; Rats; Rats, Sprague-Dawley | 2003 |
Role of phenobarbital-inducible cytochrome P450s as a source of active oxygen species in DNA-oxidation.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; DNA; Electron Spin Resonance Spectroscopy; Excitatory Amino Acid Antagonists; Hydroxyl Radical; Immunochemistry; Immunohistochemistry; Ketoconazole; Lipid Peroxidation; Liver; Membrane Proteins; Microsomes, Liver; Oxygen; Phenobarbital; Protein Isoforms; Proto-Oncogene Proteins c-jun; Proto-Oncogene Proteins c-myc; Rats; Rats, Sprague-Dawley; Steroid 16-alpha-Hydroxylase; Superoxides | 2004 |
Dimemorfan N-demethylation by mouse liver microsomal cytochrome P450 enzymes.
Topics: Animals; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Activation; Ketoconazole; Kinetics; Linear Models; Male; Mice; Mice, Inbred ICR; Microsomes, Liver; Morphinans; Orphenadrine; Oxidoreductases, N-Demethylating; Phenobarbital | 2005 |
Antiepileptic drugs affect neuronal androgen signaling via a cytochrome P450-dependent pathway.
Topics: Animals; Anticonvulsants; Cell Line, Tumor; Chloramphenicol O-Acetyltransferase; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Gene Expression; Gene Expression Regulation, Neoplastic; Immunoblotting; Isoenzymes; Ketoconazole; Membrane Proteins; Mice; Nerve Growth Factor; Neurofilament Proteins; Neurons; PC12 Cells; Phenobarbital; Phenytoin; Rats; Receptors, Androgen; Response Elements; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Signal Transduction; Transfection | 2007 |
Metabolism and action of proteasome inhibitors in primary human hepatocytes.
Topics: Adolescent; Adult; Cells, Cultured; Cytochrome P-450 CYP3A Inhibitors; Female; Hepatocytes; Humans; Infant; Ketoconazole; Leupeptins; Male; Middle Aged; Nitric Oxide; Phenobarbital; Protease Inhibitors; Proteasome Inhibitors; Rifampin | 2010 |
Biological system considerations for application of toxicogenomics in next-generation risk assessment and predictive toxicology.
Topics: Cell Line, Tumor; Gene Expression; High-Throughput Nucleotide Sequencing; Humans; Ketoconazole; Phenobarbital; Risk Assessment; RNA-Seq; Toxicogenetics | 2022 |