ketoconazole has been researched along with phenanthrenes in 13 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.69) | 18.7374 |
| 1990's | 3 (23.08) | 18.2507 |
| 2000's | 4 (30.77) | 29.6817 |
| 2010's | 4 (30.77) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Coulaud, JP; Ngo Van, P | 1 |
| Charman, WN; Edwards, GA; Khoo, SM; Porter, JH | 1 |
| Baune, B; Farinotti, R; Furlan, V; Taburet, AM | 1 |
| Baune, B; Becquemont, L; Farinotti, R; Flinois, JP; Furlan, V; Gimenez, F; Taburet, AM | 1 |
| Halpert, JR; Khan, KK | 1 |
| Cavret, S; Feidt, C | 1 |
| Brocks, DR; El-Kadi, AO; Gharavi, N; Sattari, S; Shayeganpour, A | 1 |
| Stewart, JK; Tombes, RM; Zhang, L; Zhou, Q; Zuniga, MA | 1 |
| Chen, Y; Guo, J; Huang, X; Jiang, Z; Liu, J; Liu, L; Wang, T; Yang, L; Zhang, L; Zhang, Y; Zhou, Z | 1 |
| Abdel-Aal Sabra, AN; El-Lakkany, NM; Hammam, OA; Seif El-Din, SH | 1 |
| Cao, RS; He, L; Ji, SG; Li, XF; Liu, J; Wu, JC; Ye, F; Zhang, N; Zhang, XF | 1 |
| Huang, X; Ji, J; Jiang, Z; Su, Y; Tai, T; Zhang, L | 1 |
| Huang, J; Li, F; Xiao, X; Zhang, T; Zhao, Q | 1 |
1 trial(s) available for ketoconazole and phenanthrenes
| Article | Year |
|---|---|
Metabolism of halofantrine to its equipotent metabolite, desbutylhalofantrine, is decreased when orally administered with ketoconazole.
Topics: Administration, Oral; Animals; Antimalarials; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dogs; Drug Interactions; Ketoconazole; Male; Mixed Function Oxygenases; Phenanthrenes | 1998 |
12 other study(ies) available for ketoconazole and phenanthrenes
| Article | Year |
|---|---|
[New antiparasitic drugs].
Topics: Amebicides; Anthelmintics; Antifungal Agents; Antimalarials; Artemisinins; Fluconazole; Humans; Itraconazole; Ketoconazole; Mefloquine; Phenanthrenes; Quinolines; Sesquiterpenes; Triazoles | 1988 |
Effect of selected antimalarial drugs and inhibitors of cytochrome P-450 3A4 on halofantrine metabolism by human liver microsomes.
Topics: Adolescent; Adult; Antifungal Agents; Antimalarials; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Ketoconazole; Male; Microsomes, Liver; Middle Aged; Mixed Function Oxygenases; Phenanthrenes | 1999 |
Halofantrine metabolism in microsomes in man: major role of CYP 3A4 and CYP 3A5.
Topics: Aryl Hydrocarbon Hydroxylases; Benzoflavones; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Activation; Humans; Isoenzymes; Ketoconazole; Kinetics; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Phenanthrenes; Saccharomyces cerevisiae; Substrate Specificity | 1999 |
7-Benzyloxyquinoline oxidation by P450eryF A245T: finding of a new fluorescent substrate probe.
Topics: Androstenes; Bacterial Proteins; Cells, Cultured; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Escherichia coli; Fluorescent Dyes; Genetic Vectors; Ketoconazole; Ligands; Miconazole; Mixed Function Oxygenases; Oxidation-Reduction; Oxygen; Phenanthrenes; Quinolines; Recombinant Proteins; Regression Analysis; Spectrometry, Fluorescence; Substrate Specificity; Time Factors | 2002 |
Intestinal metabolism of PAH: in vitro demonstration and study of its impact on PAH transfer through the intestinal epithelium.
Topics: Benzo(a)pyrene; Benzoflavones; Caco-2 Cells; Cell Differentiation; Cell Membrane Permeability; Cell Survival; Chromatography, Thin Layer; Colon; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Histocytochemistry; Humans; Intestinal Absorption; Intestinal Mucosa; Isoenzymes; Ketoconazole; Kinetics; Phenanthrenes; Pyrenes | 2005 |
The stereoselective metabolism of halofantrine to desbutylhalofantrine in the rat: evidence of tissue-specific enantioselectivity in microsomal metabolism.
Topics: Animals; Area Under Curve; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Intestinal Mucosa; Ketoconazole; Male; Microsomes; Microsomes, Liver; Organ Specificity; Phenanthrenes; Rats; Rats, Sprague-Dawley; Stereoisomerism | 2007 |
Mixed inhibition of P450 3A4 as a chemoprotective mechanism against aflatoxin B1-induced cytotoxicity with cis-terpenones.
Topics: Aflatoxin B1; Algorithms; Anticarcinogenic Agents; Carcinogens; Cells, Cultured; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Enzyme Inhibitors; Glutathione; Humans; Hydrolysis; In Vitro Techniques; Indicators and Reagents; Ketoconazole; Kinetics; Microsomes, Liver; Phenanthrenes | 2008 |
Sex differences in subacute toxicity and hepatic microsomal metabolism of triptolide in rats.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP3A; Dexamethasone; Diterpenes; Enzyme Inhibitors; Epoxy Compounds; Female; Ketoconazole; Liver; Male; Membrane Proteins; Microsomes, Liver; Phenanthrenes; Rats; Rats, Sprague-Dawley; Sex Factors | 2010 |
Effect of ketoconazole, a cytochrome P450 inhibitor, on the efficacy of quinine and halofantrine against Schistosoma mansoni in mice.
Topics: Animals; Anthelmintics; Disease Models, Animal; Drug Synergism; Female; Humans; Intestines; Ketoconazole; Liver; Male; Mice; Parasite Load; Phenanthrenes; Quinine; Schistosoma mansoni; Schistosomiasis mansoni; Treatment Outcome | 2013 |
Effects of triptolide on the pharmacokinetics of cyclophosphamide in rats: a possible role of cytochrome P3A4 inhibition.
Topics: Animals; Cyclophosphamide; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Diterpenes; Epoxy Compounds; Herb-Drug Interactions; Hydroxytestosterones; Immunosuppressive Agents; Injections, Intravenous; Ketoconazole; Male; Microsomes, Liver; Phenanthrenes; Rats, Sprague-Dawley | 2014 |
Glycyrrhizin accelerates the metabolism of triptolide through induction of CYP3A in rats.
Topics: Administration, Oral; Animals; Area Under Curve; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Diterpenes; Drug Interactions; Enzyme Induction; Epoxy Compounds; Female; Glycyrrhizic Acid; Ketoconazole; Liver; Male; Phenanthrenes; Rats; Rats, Wistar; Tandem Mass Spectrometry; Tripterygium | 2014 |
Effect of CYP3A4 on liver injury induced by triptolide.
Topics: Animals; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dexamethasone; Diterpenes; Epoxy Compounds; Female; Ketoconazole; Liver; Mass Spectrometry; Metabolome; Metabolomics; Mice; Mice, Inbred C57BL; Phenanthrenes | 2020 |